KR920014774A - Phenoxyalkylcarboxylic acid derivatives and preparation method thereof - Google Patents

Phenoxyalkylcarboxylic acid derivatives and preparation method thereof Download PDF

Info

Publication number
KR920014774A
KR920014774A KR1019920000340A KR920000340A KR920014774A KR 920014774 A KR920014774 A KR 920014774A KR 1019920000340 A KR1019920000340 A KR 1019920000340A KR 920000340 A KR920000340 A KR 920000340A KR 920014774 A KR920014774 A KR 920014774A
Authority
KR
South Korea
Prior art keywords
formula
compound
hydrogen atom
methyl group
ethyl group
Prior art date
Application number
KR1019920000340A
Other languages
Korean (ko)
Other versions
KR950014597B1 (en
Inventor
미쓰오 오하시
도시오 다나카
노리히사 이시카와
데쓰야 기스
Original Assignee
오기하라 히데
교린세이야쿠 가부시키가이샤
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 오기하라 히데, 교린세이야쿠 가부시키가이샤 filed Critical 오기하라 히데
Publication of KR920014774A publication Critical patent/KR920014774A/en
Application granted granted Critical
Publication of KR950014597B1 publication Critical patent/KR950014597B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/56—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/22—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and doubly-bound oxygen atoms bound to the same carbon skeleton

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

내용 없음No content

Description

페녹시알킬카복실산 유도체 및 이의 제조방법Phenoxyalkylcarboxylic acid derivatives and preparation method thereof

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음Since this is an open matter, no full text was included.

Claims (5)

일반식(1)의 페녹시알킬카복실산 유도체 또는 이의 알칼리염.Phenoxyalkylcarboxylic acid derivatives of the general formula (1) or alkali salts thereof. 상기식에서, R1은 수소원자, 메틸 그룹 또는 에틸 그룹을 나타낸다.Wherein R 1 represents a hydrogen atom, a methyl group or an ethyl group. 일반식(2)의 화합물을 일반식(3)의 화합물과 반응시켜 일반식(1a)의 화합물을 수득한 다음 이를 가수분해함을 특징으로 하여 다음 일반식(1)의 화합물을 제조하는 방법.A method of preparing a compound of formula (1), characterized in that the compound of formula (2) is reacted with a compound of formula (3) to obtain a compound of formula (1a), which is then hydrolyzed. 상기식에서, R1은 수소원자를 나타내고, R2는 메틸그룹 또는 에틸그룹을 나타내며, Y는 할로겐 원자를 나타낸다.Wherein R 1 represents a hydrogen atom, R 2 represents a methyl group or an ethyl group, and Y represents a halogen atom. 일반식(4)의 화합물을 구조식(5)의 화합물과 반응시키고, 필요한 경우, 가수분해를 시킴을 특징으로 하여 다음 일반식(1)의 화합물을 제조하는 방법.A process for preparing a compound of formula (1) characterized by reacting a compound of formula (4) with a compound of formula (5) and, if necessary, subjecting to hydrolysis. 상기식에서, R1은 수소원자, 메틸그룹 또는 에틸그룹을 나타내고, Y는 할로겐원자를 나타낸다.Wherein R 1 represents a hydrogen atom, a methyl group or an ethyl group, and Y represents a halogen atom. 일반식(6)의 화합물을 수소화시킴을 특징으로 하여 일반식(7)의 화합물을 제조하는 방법.A process for preparing the compound of formula (7), characterized by hydrogenating the compound of formula (6). 상기식에서, R은 수소원자 또는 할로게노프로필 그룹을 나타내고, R1은 수소원자, 메틸그룹 또는 에틸그룹을 나타낸다.Wherein R represents a hydrogen atom or a halogenopropyl group, and R 1 represents a hydrogen atom, a methyl group or an ethyl group. 활성 성분으로서 하나 이상의 일반식(1)의 페녹시알킬카복실산 유도체 또는 이의 알킬리염을 함유하는 항알레르기성 약제.An antiallergic agent containing, as active ingredient, at least one phenoxyalkylcarboxylic acid derivative of formula (1) or an alkylli salt thereof. 상기식에서, R1은 수소원자, 메틸그룹 또는 에틸그룹을 나타낸다.In the above formula, R 1 represents a hydrogen atom, a methyl group or an ethyl group. ※ 참고사항 : 최초출원 내용에 의하여 공개되는 것임.※ Note: This is to be disclosed by the original application.
KR1019920000340A 1991-01-18 1992-01-13 Phenoxyalkyl carboxylic acid derivatives process of preparing the same KR950014597B1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
JP5420791 1991-01-18
JP91-054207 1991-01-18
JP91-54,207 1991-01-18
JP91-359,460 1991-12-26
JP3359460A JPH0551359A (en) 1991-01-18 1991-12-26 Phenoxyalkylcarboxylic acid derivative and its production

Publications (2)

Publication Number Publication Date
KR920014774A true KR920014774A (en) 1992-08-25
KR950014597B1 KR950014597B1 (en) 1995-12-11

Family

ID=12964110

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019920000340A KR950014597B1 (en) 1991-01-18 1992-01-13 Phenoxyalkyl carboxylic acid derivatives process of preparing the same

Country Status (2)

Country Link
JP (1) JPH0551359A (en)
KR (1) KR950014597B1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2005237607B2 (en) * 2004-04-27 2010-12-16 Medicinova, Inc. Phenoxyalkycarboxylic acid derivatives in the treatment of inflammatory diseases
US9498458B2 (en) * 2014-06-02 2016-11-22 Medicinova, Inc. Method of inhibiting or treating fibrosis

Also Published As

Publication number Publication date
JPH0551359A (en) 1993-03-02
KR950014597B1 (en) 1995-12-11

Similar Documents

Publication Publication Date Title
KR850000406A (en) Method for preparing 4-chloro-2-phenylimidazole-5-acetic acid derivative
KR840005083A (en) Method for preparing amino acid derivatives useful as antihypertensive agents
KR840008014A (en) Method for preparing omeprazole salt
KR870000322A (en) Process for preparing pyridone carboxylic acid derivative
KR830006228A (en) Method for preparing imidazole derivative
KR910021366A (en) 4- (4-alkoxyphenyl) -2-butylamine derivative and preparation method thereof
KR850002096A (en) Process for preparing lactic acid solution of piperazinyl quinolone- and piperazinyl-azaquinolone-carboxylic acid
ES510599A0 (en) PROCEDURE FOR THE PREPARATION OF ACIDS (2-OXO-3-TETRAHIDROTIENILCARBAMOIL) -ALQUILTIO ACETICOS.
KR830003478A (en) Method for preparing 6-N-propyl-8α-methoxymethyl or methyl mercaptomethyl ergoline derivative
KR830009084A (en) Method for preparing quinoline carboxylic acid derivative
KR890014435A (en) Phenoxyalkylcarboxylic acid derivatives and preparation method thereof
KR890016009A (en) 1,2,5,6-tetrahydropyridine derivatives, methods for their preparation, their use as medicaments and compositions containing them
KR920014774A (en) Phenoxyalkylcarboxylic acid derivatives and preparation method thereof
KR830008990A (en) Method for preparing 2-amino-3- (halobenzoyl) -methylphenylacetic acid derivative
KR870008867A (en) 7- (1-pyrrolidinyl) -quinolone carboxylic acid derivative and preparation method thereof
ES463783A1 (en) Cis-4a-phenyl-2,3,4,4a,5,6,7,7a-octahydro-1h-2-pyrindines and pharmaceutical compositions containing them
ATE11912T1 (en) ((INDOL-3-YL)-3-AMINO-2-PROPIONYLOXY)-2ESSIGS|UREDERIVATE, PROCESS FOR THEIR PREPARATION AND MEDICATIONS THEY CONTAIN.
KR890005027A (en) Phenoxyalkylcarboxylic acid derivatives and preparation methods thereof
KR850002478A (en) Method for preparing 2- (N-pyrrolidino) -3-isobutoxy-N-substituted phenyl-N-benzyl-propylamine
KR830001890A (en) Method for preparing carbazole derivatives
KR920002594A (en) 5-isothiazolamine derivative
KR840003642A (en) Method for preparing ergot 5'S- (2R-butyl) peptide alkaloid
GB2001974A (en) Vincinic acid derivatives and process for the preparation thereof
KR830009116A (en) Method for preparing cephalosporin derivative
KR870008849A (en) Pyrazoles having germ killing effect

Legal Events

Date Code Title Description
A201 Request for examination
G160 Decision to publish patent application
E701 Decision to grant or registration of patent right
GRNT Written decision to grant
FPAY Annual fee payment

Payment date: 20031113

Year of fee payment: 9

LAPS Lapse due to unpaid annual fee