KR850000456A - Process for preparing cephalosporin ester - Google Patents

Process for preparing cephalosporin ester Download PDF

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Publication number
KR850000456A
KR850000456A KR1019840003079A KR840003079A KR850000456A KR 850000456 A KR850000456 A KR 850000456A KR 1019840003079 A KR1019840003079 A KR 1019840003079A KR 840003079 A KR840003079 A KR 840003079A KR 850000456 A KR850000456 A KR 850000456A
Authority
KR
South Korea
Prior art keywords
carbon atoms
compound
formula
lower alkyl
cycloalkyl group
Prior art date
Application number
KR1019840003079A
Other languages
Korean (ko)
Inventor
아끼오 미야께 (외 2)
Original Assignee
구라바야시 이꾸시로오
다께다야꾸힌 코오교오 가부시기 가이샤
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP9921383A external-priority patent/JPS59225193A/en
Priority claimed from JP17549683A external-priority patent/JPS6067482A/en
Application filed by 구라바야시 이꾸시로오, 다께다야꾸힌 코오교오 가부시기 가이샤 filed Critical 구라바야시 이꾸시로오
Publication of KR850000456A publication Critical patent/KR850000456A/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/36—Methylene radicals, substituted by sulfur atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

내용 없음.No content.

Description

세팔로스포린 에스테르의 제조방법Process for preparing cephalosporin ester

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음Since this is an open matter, no full text was included.

Claims (2)

하기식(II)'의 화합물 또는 이의 염을 하기식(III)'의 화합물 또는 이의 반응성 유도체와 반응시키거나, 하기식(V)의 화합물을 2-(2-아미노티아졸-4-일) 아세트산 또는 이의 반응성유도체와 반응시키거나, 하기식(IX)의 화합물을 티오우레아와 반응시키거나, 하기식(IX)의 화합물을 1-(2-디메틸 아미노에틸)-5-메르캅토-1H-테트라졸과 반응시키는 것으로 구성되는 하기식(I)의 화합물 또는 약학적으로 허용되는 이의 염을 제조하는 방법.A compound of formula (II) 'or a salt thereof is reacted with a compound of formula (III)' or a reactive derivative thereof, or a compound of formula (V) is 2- (2-aminothiazol-4-yl) React with acetic acid or a reactive derivative thereof, react the compound of formula (IX) with thiourea, or react the compound of formula (IX) with 1- (2-dimethylaminoethyl) -5-mercapto-1H- A process for preparing a compound of formula (I) or a pharmaceutically acceptable salt thereof consisting of reacting with tetrazole. 상기식에서, (1) : R1은 2-6개의 탄소원자를 가진 저급 알킬기이거나 5-7개의 탄소원자를 가진 시클로알킬기이며, R2는 5-7개의 탄소원자를 가진 시클로알킬기이거나 5-7개의 탄소원자를 가진 시클로알킬기 또는 페닐기에 의해 치환된 1-3개의 탄소원자를 갖는 저급알킬기이며; 혹은 (2) : R1은 5-7개의 탄소원자를 가진 시클로알킬기이며, R2는 1-5개의 탄소원자를 가진 저급알킬기이며; Y는 할로겐 원자이며; W는 아세톡시, 아세토아세톡시, 할로겐 또는 카르바모일옥시일.Wherein (1): R 1 is a lower alkyl group having 2-6 carbon atoms or a cycloalkyl group having 5-7 carbon atoms, and R 2 is a cycloalkyl group having 5-7 carbon atoms or 5-7 carbon atoms Lower alkyl group having 1-3 carbon atoms substituted by a cycloalkyl group or a phenyl group; Or (2): R 1 is a cycloalkyl group having 5-7 carbon atoms, and R 2 is a lower alkyl group having 1-5 carbon atoms; Y is a halogen atom; W is acetoxy, acetoacetoxy, halogen or carbamoyloxyyl. 유효성분으로서 하기식(I)의 화합물 또는 약학적으로 허용되는 이의 염으로 구성되는 약학적 조성물.A pharmaceutical composition comprising a compound of formula (I) or a pharmaceutically acceptable salt thereof as an active ingredient. 상기식에서, (1) : R1은 2-6개의 탄소원자를 가진 저급 알킬기이거나 5-7개의 탄소원자를 가진 시클로 알킬기이며, R2는 5-7개의 탄소원자를 가진 시클로알킬기이거나 5-7개의 탄소원자 또는 페닐기에 의해 치환된 1-3개의 탄소원자를 가진 저급알킬기이며; 혹은 (2) : R1은 5-7개의 탄소원자를 가진 시클로알킬기이며, R2는 1-5개의 탄소원자를 가진 저급알킬기임.Wherein (1): R 1 is a lower alkyl group having 2-6 carbon atoms or a cycloalkyl group having 5-7 carbon atoms, and R 2 is a cycloalkyl group having 5-7 carbon atoms or 5-7 carbon atoms Or a lower alkyl group having 1-3 carbon atoms substituted by a phenyl group; Or (2): R 1 is a cycloalkyl group having 5-7 carbon atoms, and R 2 is a lower alkyl group having 1-5 carbon atoms. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
KR1019840003079A 1983-06-02 1984-06-02 Process for preparing cephalosporin ester KR850000456A (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP99213/83 1983-06-02
JP9921383A JPS59225193A (en) 1983-06-02 1983-06-02 Cephalosporin ester
JP175496/83 1983-09-21
JP17549683A JPS6067482A (en) 1983-09-21 1983-09-21 Cephalosporin ester

Publications (1)

Publication Number Publication Date
KR850000456A true KR850000456A (en) 1985-02-27

Family

ID=26440367

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019840003079A KR850000456A (en) 1983-06-02 1984-06-02 Process for preparing cephalosporin ester

Country Status (4)

Country Link
US (1) US4797395A (en)
EP (1) EP0128027A3 (en)
KR (1) KR850000456A (en)
CA (1) CA1215354A (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4914091A (en) * 1984-04-02 1990-04-03 American Cyanamid Company Esters of cephalosporin derivitives
JPS60224693A (en) * 1984-04-20 1985-11-09 Takeda Chem Ind Ltd Cephalosporin ester derivative

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4189479A (en) * 1977-12-22 1980-02-19 Takeda Chemical Industries, Ltd. Cephalosporin esters
JPS5777690A (en) * 1980-10-31 1982-05-15 Takeda Chem Ind Ltd Cephalosporin derivative
JPS58189186A (en) * 1982-04-30 1983-11-04 Takeda Chem Ind Ltd Cephalosporin derivative
JPS5989691A (en) * 1982-11-15 1984-05-23 Takeda Chem Ind Ltd Cephalosporin ester
JPS60115550A (en) * 1983-11-25 1985-06-22 Takeda Chem Ind Ltd Production of 1-iodoalkyl acylate
JPS60224693A (en) * 1984-04-20 1985-11-09 Takeda Chem Ind Ltd Cephalosporin ester derivative
US4616008A (en) * 1984-05-02 1986-10-07 Takeda Chemical Industries, Ltd. Antibacterial solid composition for oral administration

Also Published As

Publication number Publication date
CA1215354A (en) 1986-12-16
US4797395A (en) 1989-01-10
EP0128027A3 (en) 1985-11-21
EP0128027A2 (en) 1984-12-12

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