KR830009080A - 피롤리디논 화합물의 제조방법 - Google Patents
피롤리디논 화합물의 제조방법 Download PDFInfo
- Publication number
- KR830009080A KR830009080A KR1019820000954A KR820000954A KR830009080A KR 830009080 A KR830009080 A KR 830009080A KR 1019820000954 A KR1019820000954 A KR 1019820000954A KR 820000954 A KR820000954 A KR 820000954A KR 830009080 A KR830009080 A KR 830009080A
- Authority
- KR
- South Korea
- Prior art keywords
- formula
- compound
- preparing
- benzodioxol
- pyrrolidinone
- Prior art date
Links
- -1 pyrrolidinone compound Chemical class 0.000 title claims 6
- 238000004519 manufacturing process Methods 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims 9
- 238000000034 method Methods 0.000 claims 3
- PAYRUJLWNCNPSJ-UHFFFAOYSA-N Aniline Chemical compound NC1=CC=CC=C1 PAYRUJLWNCNPSJ-UHFFFAOYSA-N 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- YMVNZXHKXLLWDP-UHFFFAOYSA-N 1-(1,3-benzodioxol-5-yl)pyrrolidin-2-one Chemical compound O=C1CCCN1C1=CC=C(OCO2)C2=C1 YMVNZXHKXLLWDP-UHFFFAOYSA-N 0.000 claims 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 1
- 239000003513 alkali Substances 0.000 claims 1
- 230000000202 analgesic effect Effects 0.000 claims 1
- 239000000730 antalgic agent Substances 0.000 claims 1
- 239000002260 anti-inflammatory agent Substances 0.000 claims 1
- 229940121363 anti-inflammatory agent Drugs 0.000 claims 1
- 230000003110 anti-inflammatory effect Effects 0.000 claims 1
- 239000002221 antipyretic Substances 0.000 claims 1
- 229940125716 antipyretic agent Drugs 0.000 claims 1
- 239000007864 aqueous solution Substances 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical compound [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 claims 1
- 150000003949 imides Chemical class 0.000 claims 1
- 229910052987 metal hydride Inorganic materials 0.000 claims 1
- 150000004681 metal hydrides Chemical class 0.000 claims 1
- 229910000000 metal hydroxide Inorganic materials 0.000 claims 1
- 239000003444 phase transfer catalyst Substances 0.000 claims 1
- 238000007363 ring formation reaction Methods 0.000 claims 1
- 229940124597 therapeutic agent Drugs 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (4)
- 구조식(II) 혹은 구조식(II)의 화합물을 환형화 하고, 구조식(IV)의 N(1,3-벤조디옥솔-5-일) 수신이미드를 환원시키고, 구조식(VI)의 1-(1,3-벤조디옥솔-5-일)-2-아미노-피롤리딘을 가수분해하고, 구조식(VII)의 화합물과 피롤리디논음이온(VIII)을 반응시키고, 3,4(메틸렌디옥시) 아닐린과 r-부티로락톤을 반응시키고 구조식(IX)의 화합물을 전환시키거나 구조식(X)의 화합물을 환형화하여서 구조식(I)의 1-(1,3-벤조디옥솔-5-일)-2-피롤리디논을 제조하는 방법.윗 식에서 X는 표준 분리기임.
- 청구범위 1에 잇어서 X가 표준 분리기인 구조식(II) 혹은 (III)의 화합물을 알카리수용액, 금속히드리드, 히드록시드 혹은 알콜시드 및 상전이 촉매에서 환형화하는 데에 특징이 있는 구조식(I)의 화합물 제조방법.
- 구조식(I)의 화합물과 치료제의 혼합물로 구성되는 구조식(I)의 화합물의 조성물 제조방법.
- X가 표준 분리기인 구조식(II) 혹은 (III)의 화합물을 반응시키고 구조식(I)의 1-(1,3-벤즈디옥솔-5-일)-2-피롤리돈을 알맞는 제약학적 매개물에서 산입하는 데 특징이 있는 진통, 항염 혹은 해열제의 제조방법.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US8107090 | 1981-03-06 | ||
| GB8107090 | 1981-03-06 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR830009080A true KR830009080A (ko) | 1983-12-17 |
Family
ID=10520195
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1019820000954A KR830009080A (ko) | 1981-03-06 | 1982-03-05 | 피롤리디논 화합물의 제조방법 |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US4431662A (ko) |
| EP (1) | EP0065082B1 (ko) |
| JP (1) | JPS57167983A (ko) |
| KR (1) | KR830009080A (ko) |
| AR (1) | AR231981A1 (ko) |
| AT (1) | AT381703B (ko) |
| AU (1) | AU549146B2 (ko) |
| CA (1) | CA1178280A (ko) |
| DD (1) | DD202024A5 (ko) |
| DE (1) | DE3268215D1 (ko) |
| DK (1) | DK97682A (ko) |
| ES (2) | ES510181A0 (ko) |
| FI (1) | FI70893C (ko) |
| GR (1) | GR75887B (ko) |
| IL (1) | IL65178A (ko) |
| IT (1) | IT1200921B (ko) |
| MC (1) | MC1455A1 (ko) |
| NO (1) | NO820701L (ko) |
| NZ (1) | NZ199929A (ko) |
| PL (1) | PL137717B1 (ko) |
| PT (1) | PT74538B (ko) |
| SU (1) | SU1241992A3 (ko) |
| ZA (1) | ZA821490B (ko) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2123288A (en) * | 1982-07-16 | 1984-02-01 | Wellcome Found | Anti-thrombotic agent |
| DK399083A (da) * | 1982-09-02 | 1984-03-03 | Wellcome Found | Fremgangsmaade til fremstilling af benzo- eller pyridin-derivater |
| ATE253909T1 (de) * | 1992-07-24 | 2003-11-15 | Univ California | Arzneimittel die den durch ampa rezeptoren vermittelten synaptischen response erhöhen |
| US5852008A (en) * | 1995-01-24 | 1998-12-22 | The Regents Of The University Of California | Heteroatom substituted benzoyl derivatives that enhance synaptic response mediated by receptors |
| EP1219306A1 (en) | 2000-12-29 | 2002-07-03 | Nicox S.A. | Compositions comprising cyclodextrins and NO- releasing drugs |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4110105A (en) * | 1975-03-28 | 1978-08-29 | Stauffer Chemical Company | Aromatic N-substituted halo-substituted-2-pyrrolidinones and their utility as herbicides |
| CA1115212A (en) * | 1978-02-10 | 1981-12-29 | Emilio Kyburz | Pyrrolidine derivatives |
| FR2431489A1 (fr) * | 1978-07-18 | 1980-02-15 | Unicler | Bases de schiff derivees de pyridyl-aldehydes et leur application en tant que medicaments |
| EP0022737B1 (fr) * | 1979-07-16 | 1982-06-09 | Laboratoires Sarget S.A. | Imines dérivées de l'amino-5 benzodioxole-1,3 utiles comme médicaments et leur préparation |
| US4263038A (en) * | 1979-10-01 | 1981-04-21 | Stauffer Chemical Company | Synergistic herbicidal compositions |
-
1982
- 1982-02-26 US US06/353,007 patent/US4431662A/en not_active Expired - Fee Related
- 1982-03-05 NO NO820701A patent/NO820701L/no unknown
- 1982-03-05 DE DE8282101746T patent/DE3268215D1/de not_active Expired
- 1982-03-05 PL PL1982235332A patent/PL137717B1/pl unknown
- 1982-03-05 ZA ZA821490A patent/ZA821490B/xx unknown
- 1982-03-05 SU SU823402605A patent/SU1241992A3/ru active
- 1982-03-05 GR GR67508A patent/GR75887B/el unknown
- 1982-03-05 JP JP57035013A patent/JPS57167983A/ja active Pending
- 1982-03-05 KR KR1019820000954A patent/KR830009080A/ko unknown
- 1982-03-05 AT AT0089182A patent/AT381703B/de not_active IP Right Cessation
- 1982-03-05 AU AU81149/82A patent/AU549146B2/en not_active Ceased
- 1982-03-05 IT IT47929/82A patent/IT1200921B/it active
- 1982-03-05 ES ES510181A patent/ES510181A0/es active Granted
- 1982-03-05 CA CA000397756A patent/CA1178280A/en not_active Expired
- 1982-03-05 NZ NZ199929A patent/NZ199929A/en unknown
- 1982-03-05 FI FI820780A patent/FI70893C/fi not_active IP Right Cessation
- 1982-03-05 AR AR288648A patent/AR231981A1/es active
- 1982-03-05 DK DK97682A patent/DK97682A/da not_active Application Discontinuation
- 1982-03-05 DD DD82237911A patent/DD202024A5/de unknown
- 1982-03-05 MC MC821578A patent/MC1455A1/xx unknown
- 1982-03-05 EP EP82101746A patent/EP0065082B1/en not_active Expired
- 1982-03-05 IL IL65178A patent/IL65178A/xx unknown
- 1982-03-05 PT PT74538A patent/PT74538B/pt unknown
-
1983
- 1983-01-10 ES ES518868A patent/ES518868A0/es active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| GR75887B (ko) | 1984-08-02 |
| ZA821490B (en) | 1983-10-26 |
| NO820701L (no) | 1982-09-07 |
| FI820780L (fi) | 1982-09-07 |
| SU1241992A3 (ru) | 1986-06-30 |
| EP0065082A2 (en) | 1982-11-24 |
| DD202024A5 (de) | 1983-08-24 |
| IL65178A0 (en) | 1982-05-31 |
| PT74538B (en) | 1984-11-19 |
| ES8305759A1 (es) | 1983-04-16 |
| EP0065082A3 (en) | 1983-03-16 |
| IT8247929A0 (it) | 1982-03-05 |
| JPS57167983A (en) | 1982-10-16 |
| CA1178280A (en) | 1984-11-20 |
| FI70893B (fi) | 1986-07-18 |
| PL137717B1 (en) | 1986-07-31 |
| AR231981A1 (es) | 1985-04-30 |
| AT381703B (de) | 1986-11-25 |
| MC1455A1 (fr) | 1983-02-01 |
| IL65178A (en) | 1986-02-28 |
| PT74538A (en) | 1982-04-01 |
| DK97682A (da) | 1982-09-07 |
| PL235332A1 (en) | 1983-07-18 |
| ES8501760A1 (es) | 1984-12-01 |
| AU549146B2 (en) | 1986-01-16 |
| IT1200921B (it) | 1989-01-27 |
| FI70893C (fi) | 1986-10-27 |
| DE3268215D1 (en) | 1986-02-13 |
| EP0065082B1 (en) | 1986-01-02 |
| ES518868A0 (es) | 1984-12-01 |
| NZ199929A (en) | 1985-01-31 |
| US4431662A (en) | 1984-02-14 |
| ATA89182A (de) | 1986-04-15 |
| AU8114982A (en) | 1982-09-09 |
| ES510181A0 (es) | 1983-04-16 |
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