KR830001940A - 알도즈 환원요소 억제성 퀴놀릴히단토인류 - Google Patents
알도즈 환원요소 억제성 퀴놀릴히단토인류 Download PDFInfo
- Publication number
- KR830001940A KR830001940A KR1019800000213A KR800000213A KR830001940A KR 830001940 A KR830001940 A KR 830001940A KR 1019800000213 A KR1019800000213 A KR 1019800000213A KR 800000213 A KR800000213 A KR 800000213A KR 830001940 A KR830001940 A KR 830001940A
- Authority
- KR
- South Korea
- Prior art keywords
- compound
- structural formula
- reacted
- alkyl
- hydrogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 230000002401 inhibitory effect Effects 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims 5
- 125000000217 alkyl group Chemical group 0.000 claims 3
- 125000004432 carbon atom Chemical group C* 0.000 claims 3
- 229910052739 hydrogen Inorganic materials 0.000 claims 3
- 239000001257 hydrogen Substances 0.000 claims 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 3
- -1 Alkali metal cyanide Chemical class 0.000 claims 2
- 239000002585 base Substances 0.000 claims 2
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 2
- 231100000252 nontoxic Toxicity 0.000 claims 2
- 230000003000 nontoxic effect Effects 0.000 claims 2
- ATRRKUHOCOJYRX-UHFFFAOYSA-N Ammonium bicarbonate Chemical compound [NH4+].OC([O-])=O ATRRKUHOCOJYRX-UHFFFAOYSA-N 0.000 claims 1
- 229910052783 alkali metal Inorganic materials 0.000 claims 1
- 150000001447 alkali salts Chemical class 0.000 claims 1
- 150000001350 alkyl halides Chemical class 0.000 claims 1
- 235000012501 ammonium carbonate Nutrition 0.000 claims 1
- 239000001099 ammonium carbonate Substances 0.000 claims 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 1
- 125000001246 bromo group Chemical group Br* 0.000 claims 1
- 125000001309 chloro group Chemical group Cl* 0.000 claims 1
- 125000001153 fluoro group Chemical group F* 0.000 claims 1
- 238000010438 heat treatment Methods 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 239000001301 oxygen Substances 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/12—Ophthalmic agents for cataracts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/24—Oxygen atoms attached in position 8
- C07D215/26—Alcohols; Ethers thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- C07D491/20—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D495/20—Spiro-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Diabetes (AREA)
- Ophthalmology & Optometry (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Epidemiology (AREA)
- Psychiatry (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/005,278 US4176185A (en) | 1979-01-22 | 1979-01-22 | Spiro-quinolylhydantoins |
| US5278 | 1987-02-03 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR830001940A true KR830001940A (ko) | 1983-05-19 |
Family
ID=21715098
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1019800000213A Ceased KR830001940A (ko) | 1979-01-22 | 1980-01-21 | 알도즈 환원요소 억제성 퀴놀릴히단토인류 |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US4176185A (enExample) |
| EP (1) | EP0014079B1 (enExample) |
| JP (1) | JPS5840959B2 (enExample) |
| KR (1) | KR830001940A (enExample) |
| AR (1) | AR222685A1 (enExample) |
| AT (1) | AT365588B (enExample) |
| AU (1) | AU514271B2 (enExample) |
| CA (1) | CA1140928A (enExample) |
| DE (1) | DE3060079D1 (enExample) |
| DK (1) | DK156399C (enExample) |
| EG (1) | EG15085A (enExample) |
| ES (1) | ES487923A0 (enExample) |
| FI (1) | FI69308C (enExample) |
| GR (1) | GR72408B (enExample) |
| IE (1) | IE49365B1 (enExample) |
| IL (1) | IL59177A (enExample) |
| NO (1) | NO152172C (enExample) |
| NZ (1) | NZ192650A (enExample) |
| PH (1) | PH15472A (enExample) |
| PT (1) | PT70716A (enExample) |
| YU (1) | YU41692B (enExample) |
| ZA (1) | ZA80344B (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4176185A (en) * | 1979-01-22 | 1979-11-27 | Pfizer Inc. | Spiro-quinolylhydantoins |
| US4490381A (en) * | 1979-11-13 | 1984-12-25 | Imperial Chemical Industries Plc | 1'-Substituted spiro[imidazolidine-4,3'-indoline]2,2',5-triones |
| US4248882A (en) * | 1980-02-12 | 1981-02-03 | Pfizer Inc. | Treating diabetes-associated complications with hydantoin amines |
| JPS5745185A (en) * | 1980-07-21 | 1982-03-13 | Eisai Co Ltd | Hydantoin derivative and its preparation |
| DE3261684D1 (en) * | 1981-05-12 | 1985-02-07 | Ici Plc | Pyrrole derivatives |
| HU204832B (en) * | 1987-09-04 | 1992-02-28 | Pfizer | Process for producing spiro-(imidazolidine-4,4'-pyrano/2,3-b/pyridine) derivatives and pharmaceutical compositions comprising same |
| US5068333A (en) * | 1990-03-07 | 1991-11-26 | Pfizer Inc. | 6-chloro-3,4-dihydro-pyrano [2,3-b]pyridines having the R configuration |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1135915B (de) * | 1961-06-29 | 1962-09-06 | Asta Werke Ag Chem Fab | Verfahren zur Herstellung neuer, antikonvulsiv wirksamer Spirohydantoine |
| US3876659A (en) * | 1970-09-18 | 1975-04-08 | Sandoz Ag | Spiro tricyclic isoindolines |
| US4117230A (en) * | 1976-10-18 | 1978-09-26 | Pfizer Inc. | Hydantoin derivatives as therapeutic agents |
| US4176185A (en) * | 1979-01-22 | 1979-11-27 | Pfizer Inc. | Spiro-quinolylhydantoins |
-
1979
- 1979-01-22 US US06/005,278 patent/US4176185A/en not_active Expired - Lifetime
- 1979-12-28 NO NO794318A patent/NO152172C/no unknown
-
1980
- 1980-01-12 EG EG36/80A patent/EG15085A/xx active
- 1980-01-18 CA CA000343984A patent/CA1140928A/en not_active Expired
- 1980-01-18 NZ NZ192650A patent/NZ192650A/en unknown
- 1980-01-18 YU YU131/80A patent/YU41692B/xx unknown
- 1980-01-18 AR AR279683A patent/AR222685A1/es active
- 1980-01-18 AT AT0026780A patent/AT365588B/de not_active IP Right Cessation
- 1980-01-18 DE DE8080300170T patent/DE3060079D1/de not_active Expired
- 1980-01-18 EP EP80300170A patent/EP0014079B1/en not_active Expired
- 1980-01-21 JP JP55005610A patent/JPS5840959B2/ja not_active Expired
- 1980-01-21 DK DK024280A patent/DK156399C/da not_active IP Right Cessation
- 1980-01-21 FI FI800163A patent/FI69308C/fi not_active IP Right Cessation
- 1980-01-21 ZA ZA00800344A patent/ZA80344B/xx unknown
- 1980-01-21 IE IE109/80A patent/IE49365B1/en unknown
- 1980-01-21 IL IL59177A patent/IL59177A/xx unknown
- 1980-01-21 PH PH23529A patent/PH15472A/en unknown
- 1980-01-21 KR KR1019800000213A patent/KR830001940A/ko not_active Ceased
- 1980-01-21 AU AU54766/80A patent/AU514271B2/en not_active Ceased
- 1980-01-21 PT PT70716A patent/PT70716A/pt not_active IP Right Cessation
- 1980-01-22 ES ES487923A patent/ES487923A0/es active Granted
- 1980-11-21 GR GR60999A patent/GR72408B/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IE800109L (en) | 1980-07-22 |
| FI69308B (fi) | 1985-09-30 |
| DK156399C (da) | 1990-01-08 |
| ES8103090A1 (es) | 1981-02-16 |
| EP0014079A1 (en) | 1980-08-06 |
| ES487923A0 (es) | 1981-02-16 |
| EP0014079B1 (en) | 1981-11-18 |
| AT365588B (de) | 1982-01-25 |
| IL59177A0 (en) | 1980-05-30 |
| CA1140928A (en) | 1983-02-08 |
| PH15472A (en) | 1983-01-24 |
| ZA80344B (en) | 1981-02-25 |
| AR222685A1 (es) | 1981-06-15 |
| FI69308C (fi) | 1986-01-10 |
| JPS55108873A (en) | 1980-08-21 |
| DK156399B (da) | 1989-08-14 |
| US4176185A (en) | 1979-11-27 |
| YU13180A (en) | 1983-01-21 |
| ATA26780A (de) | 1981-06-15 |
| FI800163A7 (fi) | 1980-07-23 |
| EG15085A (en) | 1986-12-30 |
| NZ192650A (en) | 1984-04-27 |
| AU514271B2 (en) | 1981-01-29 |
| IL59177A (en) | 1982-11-30 |
| NO794318L (no) | 1980-07-23 |
| NO152172C (no) | 1985-08-14 |
| DK24280A (da) | 1980-07-23 |
| IE49365B1 (en) | 1985-09-18 |
| YU41692B (en) | 1987-12-31 |
| JPS5840959B2 (ja) | 1983-09-08 |
| AU5476680A (en) | 1980-07-31 |
| DE3060079D1 (en) | 1982-01-21 |
| NO152172B (no) | 1985-05-06 |
| GR72408B (enExample) | 1983-11-02 |
| PT70716A (en) | 1980-02-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PA0109 | Patent application |
Patent event code: PA01091R01D Comment text: Patent Application Patent event date: 19800121 |
|
| PG1501 | Laying open of application | ||
| PE0902 | Notice of grounds for rejection |
Comment text: Notification of reason for refusal Patent event date: 19830819 Patent event code: PE09021S01D |
|
| PE0601 | Decision on rejection of patent |
Patent event date: 19831230 Comment text: Decision to Refuse Application Patent event code: PE06012S01D Patent event date: 19830819 Comment text: Notification of reason for refusal Patent event code: PE06011S01I |