KR830001613A - Process for the preparation of microporous bodies absorbing one or more active agents - Google Patents

Abstract

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Description

Method for producing microporous body absorbing one or more active agents

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Claims (18)

Mixing one or more active agents with a polymer or organic active solution comprising the steps of mixing the polymer-based organic solution with a relevant active agent or with a solution or dispersion in a medium that can be mixed and mixed with the organic solvent for the polymer substrate and then molding. Manufacturing method (a) preparing a preliminary solution of a polymer substrate in an organic solvent (b) preparing a dispersion or solution of the active agent involved in a well-mixed medium that is compatible with the organic solvent for the polymer matrix. (c) addition of an additive selected from the following to the active agent or to the solution or dispersant obtained in step (b) 1. Polymers of different molecular weight which are insoluble in the solvent for the polymer substrate. 2. Multifunctional reagent selected from aliphatic aldehydes, isocyanates and thiocyanates (d) mixing the polymer-based solution with or without the active agent or the solution obtained in step (b) and the additive of step (c). (e) A process for producing microporous bodies in which one or more active agents according to claim 1, comprising the steps of returning the mixture obtained in the step to a molding treatment step, are absorbed. A process for the preparation of micropores incorporating one or more active agents according to claim 2 characterized by coagulating the mixture of step (d) in a medium in which step (e) is non-solvent with respect to the polymer matrix. A process for preparing micropores comprising one or more active agents according to claim 3 characterized in that coagulation occurs by dropping the mixture into the medium. A process for the preparation of micropores incorporating one or more active agents according to claim 3 characterized in that coagulation occurs by flowing the mixture directly into the medium. A process for preparing microporous bodies in which step (e) absorbs one or more active agents according to claim 2, wherein step (d) is carried out by extrusion under dry conditions of the mixture of step. A process for the preparation of micropores incorporating one or more active agents according to claim (2), characterized in that step (e) is carried out by spinning the mixture of step (d) from a pressurized hermetic. A method of preparing a microcomplex in which an active agent is absorbed by one or more active agents according to claim 2 selected from enzyme enzyme cell antibodies, antigen levels, antiserum, hormones, coenzymes, silver pens and dyes bound to a single molecular substrate. Polymer substrates include cellulose polymers, esterified and etherified alkyl polymers, polymers or copolymers of poriaamide, acrinonnitrile, butadiene, isoprene, methacrylate, vinyl esters, vinyl chloride vinylidene chloride, styrene, vinylbutyrate A process for preparing a microporous body in which one or more active agents according to claim 2 selected from gamba-methylglutaate are absorbed. The solvent for the polymer substrate is acetone, methyl isobutyl ketone, cyclohexanone, methyl acetate, methyl cellosolve, acetate, methyl cellosolve, ethyl lactate, methylene chloride, propylene chloride, tetrachloroethane, nitromethane From chlorophenol, methacresol, vinegar, formic acid, dimethylformamide, dimethylsulfoxide, alcohol, dioxane, hydrocarbons, ketones, esters, pyridine, chloroformethanol and water mixtures, ethanol and CCl ₄ , isopropanol and methylethylketone A process for preparing microporous bodies in which one or more active agents according to the selected claim 2 are absorbed. (b) a process for preparing microporous bodies in which one or more active agents according to claim 2 selected from alcohol, ketone, ether, ester, acid pyridine, acetonitrile, cyclohexane, dimethylformamide are selected from the medium of step (b). ※ Note: The disclosure is based on the initial application.