KR20250078985A - 2 분기형 n-아세틸-d-갈락토사민 구조를 갖는 화합물의 제조 방법 - Google Patents

2 분기형 n-아세틸-d-갈락토사민 구조를 갖는 화합물의 제조 방법 Download PDF

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Publication number
KR20250078985A
KR20250078985A KR1020257013882A KR20257013882A KR20250078985A KR 20250078985 A KR20250078985 A KR 20250078985A KR 1020257013882 A KR1020257013882 A KR 1020257013882A KR 20257013882 A KR20257013882 A KR 20257013882A KR 20250078985 A KR20250078985 A KR 20250078985A
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South Korea
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formula
group
compound represented
salt
solvent
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Korean (ko)
Inventor
히로시 나가사와
나루미 아베
요시오 니시
유조 아베
다쿠미 고바야시
고헤이 사카니시
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다이이찌 산쿄 가부시키가이샤
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Publication of KR20250078985A publication Critical patent/KR20250078985A/ko
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/46—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
    • C07H15/08—Polyoxyalkylene derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/12—Acyclic radicals, not substituted by cyclic structures attached to a nitrogen atom of the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/18—Acyclic radicals, substituted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/203—Monocyclic carbocyclic rings other than cyclohexane rings; Bicyclic carbocyclic ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Saccharide Compounds (AREA)
KR1020257013882A 2022-10-05 2023-10-04 2 분기형 n-아세틸-d-갈락토사민 구조를 갖는 화합물의 제조 방법 Pending KR20250078985A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2022161149 2022-10-05
JPJP-P-2022-161149 2022-10-05
PCT/JP2023/036159 WO2024075760A1 (ja) 2022-10-05 2023-10-04 ２分岐型ｎ－アセチル－ｄ－ガラクトサミン構造を有する化合物の製造方法

Publications (1)

Publication Number Publication Date
KR20250078985A true KR20250078985A (ko) 2025-06-04

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Family Applications (1)

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KR1020257013882A Pending KR20250078985A (ko) 2022-10-05 2023-10-04 2 분기형 n-아세틸-d-갈락토사민 구조를 갖는 화합물의 제조 방법

Country Status (7)

Country Link
EP (1) EP4600253A1 (https=)
JP (1) JPWO2024075760A1 (https=)
KR (1) KR20250078985A (https=)
CN (1) CN120129686A (https=)
IL (1) IL319998A (https=)
TW (1) TW202430499A (https=)
WO (1) WO2024075760A1 (https=)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019172286A1 (ja) 2018-03-09 2019-09-12 第一三共株式会社 糖原病Ｉａ型治療薬
WO2021049504A1 (ja) 2019-09-10 2021-03-18 第一三共株式会社 肝臓送達用ＧａｌＮＡｃ－オリゴヌクレオチドコンジュゲートおよび製造方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2021014111A (es) * 2019-05-20 2021-12-10 Hoffmann La Roche Proceso para la preparacion de epimeros de fosforamidita de galnac.

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019172286A1 (ja) 2018-03-09 2019-09-12 第一三共株式会社 糖原病Ｉａ型治療薬
WO2021049504A1 (ja) 2019-09-10 2021-03-18 第一三共株式会社 肝臓送達用ＧａｌＮＡｃ－オリゴヌクレオチドコンジュゲートおよび製造方法

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
J. Chem. Soc., Perkin Trans. 1, 1987, (3), 537-45

Also Published As

Publication number Publication date
WO2024075760A1 (ja) 2024-04-11
EP4600253A1 (en) 2025-08-13
JPWO2024075760A1 (https=) 2024-04-11
IL319998A (en) 2025-06-01
TW202430499A (zh) 2024-08-01
CN120129686A (zh) 2025-06-10

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Patent event date: 20250425

Patent event code: PA01051R01D

Comment text: International Patent Application

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