KR20250077604A - Lpa 발현을 저해하기 위한 조성물 및 방법 - Google Patents

Lpa 발현을 저해하기 위한 조성물 및 방법 Download PDF

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KR20250077604A
KR20250077604A KR1020257016689A KR20257016689A KR20250077604A KR 20250077604 A KR20250077604 A KR 20250077604A KR 1020257016689 A KR1020257016689 A KR 1020257016689A KR 20257016689 A KR20257016689 A KR 20257016689A KR 20250077604 A KR20250077604 A KR 20250077604A
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synthetic
artificial sequence
rna
oligonucleotide
lpa
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KR1020257016689A
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Korean (ko)
Inventor
밥 데일 브라운
헨리크 티. 두데크
마크 에이브럼스
웬 한
안톤 투라노브
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다이서나 파마수이티컬, 인크.
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Publication of KR20250077604A publication Critical patent/KR20250077604A/ko
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/312—Phosphonates
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
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    • C12N2310/315—Phosphorothioates
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/321—2'-O-R Modification
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    • C12N2310/35—Nature of the modification
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    • C12N2310/3521—Methyl
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
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    • C12N2310/3525—MOE, methoxyethoxy
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    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
    • C12N2310/353—Nature of the modification linked to the nucleic acid via an atom other than carbon
    • C12N2310/3533—Halogen
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/50—Physical structure
    • C12N2310/53—Physical structure partially self-complementary or closed
    • C12N2310/531—Stem-loop; Hairpin

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  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
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  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Saccharide Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
KR1020257016689A 2020-08-05 2021-08-05 Lpa 발현을 저해하기 위한 조성물 및 방법 Pending KR20250077604A (ko)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US202063061676P 2020-08-05 2020-08-05
US63/061,676 2020-08-05
US202063074779P 2020-09-04 2020-09-04
US63/074,779 2020-09-04
PCT/US2021/071109 WO2022032288A1 (en) 2020-08-05 2021-08-05 Compositions and methods for inhibiting lpa expression
KR1020237006019A KR102812602B1 (ko) 2020-08-05 2021-08-05 Lpa 발현을 저해하기 위한 조성물 및 방법

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KR20250077604A true KR20250077604A (ko) 2025-05-30

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KR1020257016689A Pending KR20250077604A (ko) 2020-08-05 2021-08-05 Lpa 발현을 저해하기 위한 조성물 및 방법
KR1020237006019A Active KR102812602B1 (ko) 2020-08-05 2021-08-05 Lpa 발현을 저해하기 위한 조성물 및 방법

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Country Link
US (3) US12435336B2 (https=)
EP (1) EP4192954A1 (https=)
JP (2) JP7476422B2 (https=)
KR (2) KR20250077604A (https=)
CN (1) CN116323943A (https=)
AU (2) AU2021320550B2 (https=)
BR (1) BR112023001957A2 (https=)
CA (1) CA3185348A1 (https=)
IL (1) IL300338A (https=)
MX (1) MX2023001538A (https=)
TW (2) TW202535432A (https=)
WO (1) WO2022032288A1 (https=)

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TW202546233A (zh) * 2024-02-05 2025-12-01 美商靖因藥業（上海）有限公司 用於抑制ｌｐ（ａ）或ａｐｏｃ３之表現的多核酸分子、醫藥組合物及其用途

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US20260071219A1 (en) 2026-03-12
JP7805386B2 (ja) 2026-01-23
JP7476422B2 (ja) 2024-04-30
EP4192954A1 (en) 2023-06-14
US20240344063A1 (en) 2024-10-17
KR20230043912A (ko) 2023-03-31
TW202220673A (zh) 2022-06-01
IL300338A (en) 2023-04-01
WO2022032288A1 (en) 2022-02-10
AU2021320550A1 (en) 2023-02-16
JP2023536974A (ja) 2023-08-30
KR102812602B1 (ko) 2025-05-28
TWI886314B (zh) 2025-06-11
MX2023001538A (es) 2023-03-08
AU2021320550B2 (en) 2025-11-06
US12252691B2 (en) 2025-03-18
AU2025252633A1 (en) 2025-11-27
JP2024081668A (ja) 2024-06-18
CA3185348A1 (en) 2022-02-10
US12435336B2 (en) 2025-10-07
US20240401053A1 (en) 2024-12-05
CN116323943A (zh) 2023-06-23
BR112023001957A2 (pt) 2023-04-25
TW202535432A (zh) 2025-09-16

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