KR20250074692A - 골수이형성 증후군을 치료하는 방법 - Google Patents

골수이형성 증후군을 치료하는 방법 Download PDF

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Publication number
KR20250074692A
KR20250074692A KR1020257016709A KR20257016709A KR20250074692A KR 20250074692 A KR20250074692 A KR 20250074692A KR 1020257016709 A KR1020257016709 A KR 1020257016709A KR 20257016709 A KR20257016709 A KR 20257016709A KR 20250074692 A KR20250074692 A KR 20250074692A
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South Korea
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subject
mds
telomerase inhibitor
treatment
weeks
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KR1020257016709A
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English (en)
Korean (ko)
Inventor
알렉산드라 리조
재클린 시릴로 부솔라리
페이 후앙
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제론 코포레이션
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Publication of KR20250074692A publication Critical patent/KR20250074692A/ko
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    • G01N33/57426—
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7125—Nucleic acids or oligonucleotides having modified internucleoside linkage, i.e. other than 3'-5' phosphodiesters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57505—Immunoassay; Biospecific binding assay; Materials therefor for cancer of the blood, e.g. leukaemia
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/91—Transferases (2.)
    • G01N2333/912—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • G01N2333/91205—Phosphotransferases in general
    • G01N2333/91245—Nucleotidyltransferases (2.7.7)
    • G01N2333/9125—Nucleotidyltransferases (2.7.7) with a definite EC number (2.7.7.-)
    • G01N2333/9128—RNA-directed DNA polymerases, e.g. RT (2.7.7.49)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/573—Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicinal Preparation (AREA)
KR1020257016709A 2018-11-29 2019-11-26 골수이형성 증후군을 치료하는 방법 Pending KR20250074692A (ko)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US201862772861P 2018-11-29 2018-11-29
US62/772,861 2018-11-29
US201962811271P 2019-02-27 2019-02-27
US62/811,271 2019-02-27
US201962860557P 2019-06-12 2019-06-12
US62/860,557 2019-06-12
PCT/US2019/063372 WO2020112854A1 (en) 2018-11-29 2019-11-26 Methods of treating myelodysplastic syndrome
KR1020217019405A KR102812695B1 (ko) 2018-11-29 2019-11-26 골수이형성 증후군을 치료하는 방법

Related Parent Applications (1)

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KR1020217019405A Division KR102812695B1 (ko) 2018-11-29 2019-11-26 골수이형성 증후군을 치료하는 방법

Publications (1)

Publication Number Publication Date
KR20250074692A true KR20250074692A (ko) 2025-05-27

Family

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KR1020257016709A Pending KR20250074692A (ko) 2018-11-29 2019-11-26 골수이형성 증후군을 치료하는 방법
KR1020217019405A Active KR102812695B1 (ko) 2018-11-29 2019-11-26 골수이형성 증후군을 치료하는 방법

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Country Status (15)

Country Link
US (2) US12201645B2 (https=)
EP (1) EP3887537A4 (https=)
JP (3) JP7650798B2 (https=)
KR (2) KR20250074692A (https=)
CN (1) CN113631719A (https=)
AU (2) AU2019389005B2 (https=)
BR (1) BR112021010406A2 (https=)
CA (1) CA3120704A1 (https=)
CL (1) CL2021001386A1 (https=)
IL (1) IL283054A (https=)
MX (1) MX2021006131A (https=)
SG (1) SG11202105573PA (https=)
TW (2) TW202523338A (https=)
UA (1) UA130012C2 (https=)
WO (1) WO2020112854A1 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL321881A (en) * 2023-01-03 2025-09-01 Geron Corp Methods for treating myelodysplastic syndrome and monitoring treatment
CN116189765B (zh) * 2023-02-23 2023-08-15 上海捷易生物科技有限公司 一种iPS细胞遗传学风险评估系统及应用

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Also Published As

Publication number Publication date
AU2019389005A1 (en) 2021-06-24
US12201645B2 (en) 2025-01-21
EP3887537A4 (en) 2023-04-12
US20200171072A1 (en) 2020-06-04
SG11202105573PA (en) 2021-06-29
WO2020112854A1 (en) 2020-06-04
CL2021001386A1 (es) 2021-12-10
UA130012C2 (uk) 2025-10-15
JP7650798B2 (ja) 2025-03-25
JP2025020318A (ja) 2025-02-12
TW202038973A (zh) 2020-11-01
BR112021010406A2 (pt) 2021-08-24
AU2019389005B2 (en) 2024-06-20
CA3120704A1 (en) 2020-06-04
KR20210110303A (ko) 2021-09-07
TW202523338A (zh) 2025-06-16
JP2023016965A (ja) 2023-02-02
IL283054A (en) 2021-06-30
MX2021006131A (es) 2021-06-23
US20250170160A1 (en) 2025-05-29
JP2022513162A (ja) 2022-02-07
AU2024208794A1 (en) 2024-09-05
KR102812695B1 (ko) 2025-05-26
CN113631719A (zh) 2021-11-09
EP3887537A1 (en) 2021-10-06

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