KR20250054121A - 라파마이신 유도체 - Google Patents

라파마이신 유도체 Download PDF

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Publication number
KR20250054121A
KR20250054121A KR1020257011373A KR20257011373A KR20250054121A KR 20250054121 A KR20250054121 A KR 20250054121A KR 1020257011373 A KR1020257011373 A KR 1020257011373A KR 20257011373 A KR20257011373 A KR 20257011373A KR 20250054121 A KR20250054121 A KR 20250054121A
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South Korea
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disease
cancer
pharmaceutically acceptable
compound
formula
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Korean (ko)
Inventor
사이먼 보나지
마이클 코널리
데이비드 조나단 글래스
마누엘 미할릭
앤드류 윌리엄 패터슨
실비오 로고
테아 샤블라카제
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노파르티스 아게
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Publication of KR20250054121A publication Critical patent/KR20250054121A/ko
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/18—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/18—Bridged systems
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
    • A—HUMAN NECESSITIES
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    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Diabetes (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Hematology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Obesity (AREA)
  • Cardiology (AREA)
  • Immunology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Oncology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pain & Pain Management (AREA)
  • Communicable Diseases (AREA)
  • Pulmonology (AREA)
  • Endocrinology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Emergency Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Vascular Medicine (AREA)
KR1020257011373A 2017-09-26 2018-09-25 라파마이신 유도체 Pending KR20250054121A (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201762563312P 2017-09-26 2017-09-26
US62/563,312 2017-09-26
KR1020207007749A KR102794731B1 (ko) 2017-09-26 2018-09-25 라파마이신 유도체
PCT/IB2018/057422 WO2019064182A1 (en) 2017-09-26 2018-09-25 RAPAMYCIN DERIVATIVES

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
KR1020207007749A Division KR102794731B1 (ko) 2017-09-26 2018-09-25 라파마이신 유도체

Publications (1)

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KR20250054121A true KR20250054121A (ko) 2025-04-22

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KR1020257011373A Pending KR20250054121A (ko) 2017-09-26 2018-09-25 라파마이신 유도체
KR1020207007749A Active KR102794731B1 (ko) 2017-09-26 2018-09-25 라파마이신 유도체

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Country Status (23)

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US (4) US10800793B2 (enExample)
EP (2) EP4365179A3 (enExample)
JP (2) JP7387590B2 (enExample)
KR (2) KR20250054121A (enExample)
CN (2) CN117417351A (enExample)
AR (1) AR112834A1 (enExample)
AU (1) AU2018342784B2 (enExample)
BR (1) BR112020005898A2 (enExample)
CA (1) CA3078191A1 (enExample)
DK (1) DK3687999T3 (enExample)
ES (1) ES2973975T3 (enExample)
FI (1) FI3687999T3 (enExample)
HR (1) HRP20240199T8 (enExample)
HU (1) HUE065692T2 (enExample)
LT (1) LT3687999T (enExample)
MX (2) MX2020007265A (enExample)
PL (1) PL3687999T3 (enExample)
PT (1) PT3687999T (enExample)
RS (1) RS65270B1 (enExample)
SI (1) SI3687999T1 (enExample)
TW (1) TW201920189A (enExample)
UY (1) UY37900A (enExample)
WO (1) WO2019064182A1 (enExample)

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CN108697701B (zh) 2016-02-04 2021-10-26 约翰霍普金斯大学 平衡型核苷转运蛋白1的抑制剂Rapadocin及其用途
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KR102643707B1 (ko) 2019-01-22 2024-03-04 에오비안 파마슈티컬스, 인크. Mtorc 조절제 및 이의 용도
HRP20240633T1 (hr) * 2019-03-26 2024-08-02 Novartis Ag Izotiazolidin 1,1-dioksid i 1,4-butan sulton derivati rapamicina i njihova uporaba
KR102486721B1 (ko) * 2019-08-23 2023-01-10 이화여자대학교 산학협력단 신규 mTOR 억제제 화합물 및 이의 용도
KR102497821B1 (ko) * 2019-08-23 2023-02-08 이화여자대학교 산학협력단 신규 mTOR 억제제 화합물 및 이의 용도
TW202126323A (zh) * 2019-10-01 2021-07-16 約翰斯赫普金斯大學 雷帕弗辛（Ｒａｐａｆｕｃｉｎ）衍生化合物及其使用方法
JP2023506410A (ja) 2019-12-05 2023-02-16 アナクリア セラピューティクス， インコーポレイテッド ラパマイシン類似体及びその使用
DE102020203224A1 (de) 2020-03-12 2021-09-16 Heinrich-Heine-Universität Düsseldorf Inhibition von FKBP1A zur Therapie des Triple-negativen Mammakarzinoms
WO2021180840A1 (de) 2020-03-12 2021-09-16 Heinrich-Heine-Universität Düsseldorf Inhibition von fkbp1a zur therapie des triple-negativen mammakarzinoms
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WO2022020522A2 (en) * 2020-07-21 2022-01-27 Aeovian Pharmaceuticals, Inc. Mtorc1 modulators and uses thereof
TW202206093A (zh) * 2020-08-12 2022-02-16 中國醫藥大學 Ｓｅｍａ３ｄ拮抗劑用於預防或治療神經退化性疾病以及延長壽命之用途
CN119604293A (zh) 2022-05-25 2025-03-11 锐新医药公司 用mTOR抑制剂治疗癌症的方法
AU2024242998A1 (en) * 2023-04-07 2025-10-23 Regeneron Pharmaceuticals, Inc. Selective rapamycin analogs and uses thereof
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