CA3078191A1 - Rapamycin derivatives - Google Patents

Rapamycin derivatives Download PDF

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Publication number
CA3078191A1
CA3078191A1 CA3078191A CA3078191A CA3078191A1 CA 3078191 A1 CA3078191 A1 CA 3078191A1 CA 3078191 A CA3078191 A CA 3078191A CA 3078191 A CA3078191 A CA 3078191A CA 3078191 A1 CA3078191 A1 CA 3078191A1
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Canada
Prior art keywords
cancer
disease
pharmaceutically acceptable
disorder
acceptable salt
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Pending
Application number
CA3078191A
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English (en)
French (fr)
Inventor
Simone BONAZZI
Michael Connolly
David Jonathan Glass
Manuel Mihalic
Andrew William PATTERSON
Silvio Roggo
Tea Shavlakadze
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Novartis AG
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Novartis AG
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Publication of CA3078191A1 publication Critical patent/CA3078191A1/en
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/18—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/18—Bridged systems
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
    • A—HUMAN NECESSITIES
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    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

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  • Health & Medical Sciences (AREA)
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  • Organic Chemistry (AREA)
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  • Veterinary Medicine (AREA)
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  • Public Health (AREA)
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  • Animal Behavior & Ethology (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
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  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Hematology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Immunology (AREA)
  • Obesity (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Oncology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pain & Pain Management (AREA)
  • Communicable Diseases (AREA)
  • Endocrinology (AREA)
  • Pulmonology (AREA)
  • Psychiatry (AREA)
  • Vascular Medicine (AREA)
  • Emergency Medicine (AREA)
  • Psychology (AREA)
  • Child & Adolescent Psychology (AREA)
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CA3078191A 2017-09-26 2018-09-25 Rapamycin derivatives Pending CA3078191A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762563312P 2017-09-26 2017-09-26
US62/563,312 2017-09-26
PCT/IB2018/057422 WO2019064182A1 (en) 2017-09-26 2018-09-25 RAPAMYCIN DERIVATIVES

Publications (1)

Publication Number Publication Date
CA3078191A1 true CA3078191A1 (en) 2019-04-04

Family

ID=63857991

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3078191A Pending CA3078191A1 (en) 2017-09-26 2018-09-25 Rapamycin derivatives

Country Status (23)

Country Link
US (4) US10800793B2 (enExample)
EP (2) EP3687999B1 (enExample)
JP (2) JP7387590B2 (enExample)
KR (2) KR102794731B1 (enExample)
CN (2) CN117417351A (enExample)
AR (1) AR112834A1 (enExample)
AU (1) AU2018342784B2 (enExample)
BR (1) BR112020005898A2 (enExample)
CA (1) CA3078191A1 (enExample)
DK (1) DK3687999T3 (enExample)
ES (1) ES2973975T3 (enExample)
FI (1) FI3687999T3 (enExample)
HR (1) HRP20240199T8 (enExample)
HU (1) HUE065692T2 (enExample)
LT (1) LT3687999T (enExample)
MX (2) MX2020007265A (enExample)
PL (1) PL3687999T3 (enExample)
PT (1) PT3687999T (enExample)
RS (1) RS65270B1 (enExample)
SI (1) SI3687999T1 (enExample)
TW (1) TW201920189A (enExample)
UY (1) UY37900A (enExample)
WO (1) WO2019064182A1 (enExample)

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TW202126323A (zh) * 2019-10-01 2021-07-16 約翰斯赫普金斯大學 雷帕弗辛（Ｒａｐａｆｕｃｉｎ）衍生化合物及其使用方法
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US20230133761A1 (en) 2020-03-12 2023-05-04 Heinrich-Heine-Universität Düsseldorf Inhibition of fkbp1a for the treatment of triple-negative mammary carcinoma
DE102020203224A1 (de) 2020-03-12 2021-09-16 Heinrich-Heine-Universität Düsseldorf Inhibition von FKBP1A zur Therapie des Triple-negativen Mammakarzinoms
CN115776907B (zh) 2020-03-27 2025-02-25 艾奥维安制药公司 Mtorc1调节剂及其用途
CN121426814A (zh) * 2020-07-21 2026-01-30 艾奥维安制药公司 Mtorc1调节剂及其用途
TW202206093A (zh) * 2020-08-12 2022-02-16 中國醫藥大學 Ｓｅｍａ３ｄ拮抗劑用於預防或治療神經退化性疾病以及延長壽命之用途
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