KR20250040575A - Mri 조영제로서 사용하기 위한 철(iii) 착화합물의 리간드로서의 1,4-비스-(2-하이드록시-벤질)-1,4,7-트라이아자사이클로노난 유도체 및 유사 화합물 - Google Patents

Mri 조영제로서 사용하기 위한 철(iii) 착화합물의 리간드로서의 1,4-비스-(2-하이드록시-벤질)-1,4,7-트라이아자사이클로노난 유도체 및 유사 화합물 Download PDF

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Publication number
KR20250040575A
KR20250040575A KR1020247038908A KR20247038908A KR20250040575A KR 20250040575 A KR20250040575 A KR 20250040575A KR 1020247038908 A KR1020247038908 A KR 1020247038908A KR 20247038908 A KR20247038908 A KR 20247038908A KR 20250040575 A KR20250040575 A KR 20250040575A
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KR
South Korea
Prior art keywords
hydroxy
methyl
methylene
bis
phenylene
Prior art date
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Pending
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KR1020247038908A
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English (en)
Korean (ko)
Inventor
마우로 보타
로렌조 테이
파비오 카르니아토
졸트 바라냐이
마리안젤라 보칼론
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브라코 이미징 에스.피.에이.
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Publication of KR20250040575A publication Critical patent/KR20250040575A/ko
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D255/00—Heterocyclic compounds containing rings having three nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D249/00 - C07D253/00
    • C07D255/02—Heterocyclic compounds containing rings having three nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D249/00 - C07D253/00 not condensed with other rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
    • A61K49/106—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being cyclic, e.g. DOTA

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
KR1020247038908A 2022-07-28 2023-07-28 Mri 조영제로서 사용하기 위한 철(iii) 착화합물의 리간드로서의 1,4-비스-(2-하이드록시-벤질)-1,4,7-트라이아자사이클로노난 유도체 및 유사 화합물 Pending KR20250040575A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP22187403.5 2022-07-28
EP22187403 2022-07-28
PCT/EP2023/071027 WO2024023314A1 (en) 2022-07-28 2023-07-28 1,4-bis-(2-hydroxy-benzyl)-1,4,7-triazacyclononane derivatives and similar compounds as ligands in iron(iii) complexes for use as mri contrast agents

Publications (1)

Publication Number Publication Date
KR20250040575A true KR20250040575A (ko) 2025-03-24

Family

ID=82780974

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020247038908A Pending KR20250040575A (ko) 2022-07-28 2023-07-28 Mri 조영제로서 사용하기 위한 철(iii) 착화합물의 리간드로서의 1,4-비스-(2-하이드록시-벤질)-1,4,7-트라이아자사이클로노난 유도체 및 유사 화합물

Country Status (10)

Country Link
US (1) US12358880B2 (https=)
EP (1) EP4561995A1 (https=)
JP (1) JP2025524769A (https=)
KR (1) KR20250040575A (https=)
CN (1) CN119343336A (https=)
AU (1) AU2023313342A1 (https=)
CA (1) CA3252691A1 (https=)
IL (1) IL317339A (https=)
MX (1) MX2024015341A (https=)
WO (1) WO2024023314A1 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2025163025A1 (en) 2024-01-31 2025-08-07 Bracco Imaging Spa Pyridophane macrocyclic ligands and fe(iii) complexes thereof
CN119499407B (zh) * 2024-11-25 2026-04-07 中国科学院精密测量科学与技术创新研究院 一种Fe基T7肽靶向脑胶质瘤小分子磁共振造影剂及其制备合成方法和应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7390284B2 (ja) 2017-05-19 2023-12-01 ザ リサーチ ファウンデイション フォー ザ ステイト ユニバーシティー オブ ニューヨーク 鉄（ｉｉｉ）ｍｒｉ造影剤として使用するための化合物
CN112996764B (zh) 2018-11-12 2023-11-21 伯拉考成像股份公司 螯合aazta缀合物及其配合物

Also Published As

Publication number Publication date
IL317339A (en) 2025-01-01
EP4561995A1 (en) 2025-06-04
JP2025524769A (ja) 2025-08-01
AU2023313342A1 (en) 2024-12-19
CA3252691A1 (en) 2024-02-01
US12358880B2 (en) 2025-07-15
CN119343336A (zh) 2025-01-21
US20250163007A1 (en) 2025-05-22
WO2024023314A1 (en) 2024-02-01
MX2024015341A (es) 2025-02-10

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Date Code Title Description
PA0105 International application

Patent event date: 20241122

Patent event code: PA01051R01D

Comment text: International Patent Application

PG1501 Laying open of application