CN119343336A - 作为用于用作mri造影剂的铁(iii)络合物中的配体的1,4-二-(2-羟基-苄基)-1,4,7-三氮杂环壬烷衍生物和类似化合物 - Google Patents
作为用于用作mri造影剂的铁(iii)络合物中的配体的1,4-二-(2-羟基-苄基)-1,4,7-三氮杂环壬烷衍生物和类似化合物 Download PDFInfo
- Publication number
- CN119343336A CN119343336A CN202380045442.5A CN202380045442A CN119343336A CN 119343336 A CN119343336 A CN 119343336A CN 202380045442 A CN202380045442 A CN 202380045442A CN 119343336 A CN119343336 A CN 119343336A
- Authority
- CN
- China
- Prior art keywords
- hydroxy
- bis
- methyl
- methylene
- phenylene
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D255/00—Heterocyclic compounds containing rings having three nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D249/00 - C07D253/00
- C07D255/02—Heterocyclic compounds containing rings having three nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D249/00 - C07D253/00 not condensed with other rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/10—Organic compounds
- A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
- A61K49/106—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being cyclic, e.g. DOTA
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Radiology & Medical Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP22187403.5 | 2022-07-28 | ||
| EP22187403 | 2022-07-28 | ||
| PCT/EP2023/071027 WO2024023314A1 (en) | 2022-07-28 | 2023-07-28 | 1,4-bis-(2-hydroxy-benzyl)-1,4,7-triazacyclononane derivatives and similar compounds as ligands in iron(iii) complexes for use as mri contrast agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN119343336A true CN119343336A (zh) | 2025-01-21 |
Family
ID=82780974
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202380045442.5A Pending CN119343336A (zh) | 2022-07-28 | 2023-07-28 | 作为用于用作mri造影剂的铁(iii)络合物中的配体的1,4-二-(2-羟基-苄基)-1,4,7-三氮杂环壬烷衍生物和类似化合物 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US12358880B2 (https=) |
| EP (1) | EP4561995A1 (https=) |
| JP (1) | JP2025524769A (https=) |
| KR (1) | KR20250040575A (https=) |
| CN (1) | CN119343336A (https=) |
| AU (1) | AU2023313342A1 (https=) |
| CA (1) | CA3252691A1 (https=) |
| IL (1) | IL317339A (https=) |
| MX (1) | MX2024015341A (https=) |
| WO (1) | WO2024023314A1 (https=) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2025163025A1 (en) | 2024-01-31 | 2025-08-07 | Bracco Imaging Spa | Pyridophane macrocyclic ligands and fe(iii) complexes thereof |
| CN119499407B (zh) * | 2024-11-25 | 2026-04-07 | 中国科学院精密测量科学与技术创新研究院 | 一种Fe基T7肽靶向脑胶质瘤小分子磁共振造影剂及其制备合成方法和应用 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP7390284B2 (ja) | 2017-05-19 | 2023-12-01 | ザ リサーチ ファウンデイション フォー ザ ステイト ユニバーシティー オブ ニューヨーク | 鉄（ｉｉｉ）ｍｒｉ造影剤として使用するための化合物 |
| CN112996764B (zh) | 2018-11-12 | 2023-11-21 | 伯拉考成像股份公司 | 螯合aazta缀合物及其配合物 |
-
2023
- 2023-07-28 JP JP2024571340A patent/JP2025524769A/ja active Pending
- 2023-07-28 KR KR1020247038908A patent/KR20250040575A/ko active Pending
- 2023-07-28 AU AU2023313342A patent/AU2023313342A1/en active Pending
- 2023-07-28 US US18/871,962 patent/US12358880B2/en active Active
- 2023-07-28 CN CN202380045442.5A patent/CN119343336A/zh active Pending
- 2023-07-28 WO PCT/EP2023/071027 patent/WO2024023314A1/en not_active Ceased
- 2023-07-28 CA CA3252691A patent/CA3252691A1/en active Pending
- 2023-07-28 IL IL317339A patent/IL317339A/en unknown
- 2023-07-28 EP EP23750964.1A patent/EP4561995A1/en active Pending
-
2024
- 2024-12-10 MX MX2024015341A patent/MX2024015341A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IL317339A (en) | 2025-01-01 |
| KR20250040575A (ko) | 2025-03-24 |
| EP4561995A1 (en) | 2025-06-04 |
| JP2025524769A (ja) | 2025-08-01 |
| AU2023313342A1 (en) | 2024-12-19 |
| CA3252691A1 (en) | 2024-02-01 |
| US12358880B2 (en) | 2025-07-15 |
| US20250163007A1 (en) | 2025-05-22 |
| WO2024023314A1 (en) | 2024-02-01 |
| MX2024015341A (es) | 2025-02-10 |
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