KR20250025354A - 항-ilt3 항체 및 이의 용도 - Google Patents

항-ilt3 항체 및 이의 용도 Download PDF

Info

Publication number
KR20250025354A
KR20250025354A KR1020247037976A KR20247037976A KR20250025354A KR 20250025354 A KR20250025354 A KR 20250025354A KR 1020247037976 A KR1020247037976 A KR 1020247037976A KR 20247037976 A KR20247037976 A KR 20247037976A KR 20250025354 A KR20250025354 A KR 20250025354A
Authority
KR
South Korea
Prior art keywords
seq
amino acid
antibody
acid sequence
antigen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
KR1020247037976A
Other languages
English (en)
Korean (ko)
Inventor
추리 페레츠
이라나 만델
요아브 피젬
리아트 이안코비치
모티 하킴
아비도르 슐만
야이르 사피르
테히라 벤-모세
Original Assignee
비온드 바이오로직스 엘티디
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 비온드 바이오로직스 엘티디 filed Critical 비온드 바이오로직스 엘티디
Publication of KR20250025354A publication Critical patent/KR20250025354A/ko
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
KR1020247037976A 2022-04-25 2023-04-25 항-ilt3 항체 및 이의 용도 Pending KR20250025354A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202263334365P 2022-04-25 2022-04-25
US63/334,365 2022-04-25
PCT/IL2023/050426 WO2023209716A1 (en) 2022-04-25 2023-04-25 Anti-ilt3 antibodies and use thereof

Publications (1)

Publication Number Publication Date
KR20250025354A true KR20250025354A (ko) 2025-02-21

Family

ID=86604937

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020247037976A Pending KR20250025354A (ko) 2022-04-25 2023-04-25 항-ilt3 항체 및 이의 용도

Country Status (9)

Country Link
US (1) US20250277032A1 (https=)
EP (1) EP4514472A1 (https=)
JP (1) JP2025513588A (https=)
KR (1) KR20250025354A (https=)
CN (1) CN119487072A (https=)
AU (1) AU2023258644A1 (https=)
CA (1) CA3249138A1 (https=)
IL (1) IL316523A (https=)
WO (1) WO2023209716A1 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2025062392A1 (en) * 2023-09-20 2025-03-27 Biond Biologics Ltd. Anti-ilt3 blockade combinations
WO2025141589A1 (en) 2023-12-31 2025-07-03 Biond Biologics Ltd. Treatment of cancer with anti-ilt3 antibodies

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4235871A (en) 1978-02-24 1980-11-25 Papahadjopoulos Demetrios P Method of encapsulating biologically active materials in lipid vesicles
US4501728A (en) 1983-01-06 1985-02-26 Technology Unlimited, Inc. Masking of liposomes from RES recognition
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US4666828A (en) 1984-08-15 1987-05-19 The General Hospital Corporation Test for Huntington's disease
US5019369A (en) 1984-10-22 1991-05-28 Vestar, Inc. Method of targeting tumors in humans
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US4801531A (en) 1985-04-17 1989-01-31 Biotechnology Research Partners, Ltd. Apo AI/CIII genomic polymorphisms predictive of atherosclerosis
US4837028A (en) 1986-12-24 1989-06-06 Liposome Technology, Inc. Liposomes with enhanced circulation time
US5272057A (en) 1988-10-14 1993-12-21 Georgetown University Method of detecting a predisposition to cancer by the use of restriction fragment length polymorphism of the gene for human poly (ADP-ribose) polymerase
US5192659A (en) 1989-08-25 1993-03-09 Genetype Ag Intron sequence analysis method for detection of adjacent and remote locus alleles as haplotypes
US5641870A (en) 1995-04-20 1997-06-24 Genentech, Inc. Low pH hydrophobic interaction chromatography for antibody purification
EP1907001B1 (en) 2005-06-17 2015-07-15 Merck Sharp & Dohme Corp. Ilt3 binding molecules and uses therefor
WO2013033734A1 (en) * 2011-09-02 2013-03-07 The Trustees Of Columbia University In The City Of New York Diagnosis and Treatment of Cancer Expressing ILT3 or ILT3 Ligand
CA2977544C (en) * 2015-03-06 2023-12-19 The Board Of Regents Of The University Of Texas System Anti-lilrb antibodies and their use in detecting and treating cancer
EP3538141A4 (en) 2016-11-10 2020-07-15 Merck Sharp & Dohme Corp. LIGAND ILT3
WO2018148494A1 (en) * 2017-02-09 2018-08-16 Bluefin Biomedicine, Inc. Anti-ilt3 antibodies and antibody drug conjugates
CN111712518B (zh) 2017-11-17 2025-03-25 默沙东有限责任公司 对免疫球蛋白样转录物3(ilt3)具有特异性的抗体及其用途
CA3109366A1 (en) 2018-09-13 2020-03-19 The Board Of Regents Of The University Of Texas System Novel lilrb4 antibodies and uses thereof
JP2022522775A (ja) * 2019-03-01 2022-04-20 ボード オブ リージェンツ，ザ ユニバーシティ オブ テキサス システム Ｌｉｌｒｂ４結合抗体およびその使用方法
PH12022551462A1 (en) 2019-12-19 2023-11-13 Ngm Biopharmaceuticals Inc Ilt3-binding agents and methods of use thereof
AU2021236302A1 (en) * 2020-03-12 2022-10-20 Immune-Onc Therapeutics, Inc. Novel anti-LILRB4 antibodies and derivative products

Also Published As

Publication number Publication date
US20250277032A1 (en) 2025-09-04
CN119487072A (zh) 2025-02-18
JP2025513588A (ja) 2025-04-24
WO2023209716A1 (en) 2023-11-02
EP4514472A1 (en) 2025-03-05
CA3249138A1 (en) 2023-11-02
AU2023258644A1 (en) 2024-12-05
IL316523A (en) 2024-12-01

Similar Documents

Publication Publication Date Title
JP7320498B2 (ja) Ｇｍ－ｃｓｆアンタゴニストを使用した免疫療法関連毒性の治療方法
KR102433076B1 (ko) Ilt2에 대한 항체 및 이의 용도
US20190055316A1 (en) Anti-mesothelin binding proteins
CN114026124A (zh) 抗hvem抗体及其用途
US12503510B2 (en) Small shedding blocking agents
JP2022517461A (ja) Ｇｍ－ｃｓｆアンタゴニストを使用した免疫療法関連毒性の治療方法
US20250277032A1 (en) Anti-ilt3 antibodies and use thereof
KR20220108137A (ko) Mmp 억제의 용도
KR20220152555A (ko) 증가된 안정성을 가진 쉐딩 차단제
WO2023031943A2 (en) Cd28 shedding blocking agents
WO2025062392A1 (en) Anti-ilt3 blockade combinations
US20230312732A1 (en) Ephb2 antibody and use thereof in combination therapy
KR20240047954A (ko) 향상된 항-hvem 항체 및 이의 용도
CN118541387A (zh) Cd28脱落阻断剂
HK40068325A (en) Anti-hvem antibodies and use thereof
HK40064257A (en) Small shedding blocking agents

Legal Events

Date Code Title Description
PA0105 International application

Patent event date: 20241114

Patent event code: PA01051R01D

Comment text: International Patent Application

PG1501 Laying open of application