KR20250006325A - 전립선 암의 검출 - Google Patents

전립선 암의 검출 Download PDF

Info

Publication number
KR20250006325A
KR20250006325A KR1020247042357A KR20247042357A KR20250006325A KR 20250006325 A KR20250006325 A KR 20250006325A KR 1020247042357 A KR1020247042357 A KR 1020247042357A KR 20247042357 A KR20247042357 A KR 20247042357A KR 20250006325 A KR20250006325 A KR 20250006325A
Authority
KR
South Korea
Prior art keywords
methylation
primer set
sequence numbers
set consisting
sample
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
KR1020247042357A
Other languages
English (en)
Korean (ko)
Inventor
데이비드 에이. 알퀴스트
윌리엄 알. 테일러
존 비. 키셀
트레이시 씨. 얩
더글라스 더블유. 마호니
브라이언 에이. 듀케
메튜 티. 게트먼
하팀 티. 알라위
Original Assignee
메이오 파운데이션 포 메디칼 에쥬케이션 앤드 리써치
이그잭트 사이언시즈 코포레이션
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 메이오 파운데이션 포 메디칼 에쥬케이션 앤드 리써치, 이그잭트 사이언시즈 코포레이션 filed Critical 메이오 파운데이션 포 메디칼 에쥬케이션 앤드 리써치
Publication of KR20250006325A publication Critical patent/KR20250006325A/ko
Pending legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813Hybridisation assays
    • C12Q1/6827Hybridisation assays for detection of mutation or polymorphism
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/154Methylation markers
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/16Primer sets for multiplex assays

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Pathology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
KR1020247042357A 2017-02-28 2018-02-27 전립선 암의 검출 Pending KR20250006325A (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201762464800P 2017-02-28 2017-02-28
US62/464,800 2017-02-28
KR1020197025327A KR102747156B1 (ko) 2017-02-28 2018-02-27 전립선 암의 검출
PCT/US2018/019982 WO2018160576A1 (en) 2017-02-28 2018-02-27 Detecting prostate cancer

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
KR1020197025327A Division KR102747156B1 (ko) 2017-02-28 2018-02-27 전립선 암의 검출

Publications (1)

Publication Number Publication Date
KR20250006325A true KR20250006325A (ko) 2025-01-10

Family

ID=63245681

Family Applications (2)

Application Number Title Priority Date Filing Date
KR1020247042357A Pending KR20250006325A (ko) 2017-02-28 2018-02-27 전립선 암의 검출
KR1020197025327A Active KR102747156B1 (ko) 2017-02-28 2018-02-27 전립선 암의 검출

Family Applications After (1)

Application Number Title Priority Date Filing Date
KR1020197025327A Active KR102747156B1 (ko) 2017-02-28 2018-02-27 전립선 암의 검출

Country Status (8)

Country Link
US (3) US10934592B2 (https=)
EP (1) EP3589732A4 (https=)
JP (3) JP7356349B2 (https=)
KR (2) KR20250006325A (https=)
CN (2) CN110431241B (https=)
AU (2) AU2018229294B2 (https=)
CA (1) CA3054836A1 (https=)
WO (1) WO2018160576A1 (https=)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2816122A1 (en) 2008-02-15 2014-12-24 Mayo Foundation For Medical Education And Research Detecting neoplasm from a stool sample
US8361720B2 (en) 2010-11-15 2013-01-29 Exact Sciences Corporation Real time cleavage assay
ES2859645T3 (es) 2013-03-14 2021-10-04 Mayo Found Medical Education & Res Detección de neoplasia
EP4234722A3 (en) 2014-03-31 2023-09-20 Mayo Foundation for Medical Education and Research Detecting colorectal neoplasm
US10184154B2 (en) 2014-09-26 2019-01-22 Mayo Foundation For Medical Education And Research Detecting cholangiocarcinoma
CN107532124B (zh) 2015-03-27 2022-08-09 精密科学公司 检测食管疾病
CN108138235B (zh) 2015-08-31 2022-04-15 梅约医药教育及研究基金会 检测胃肿瘤
AU2016343937B2 (en) 2015-10-30 2023-01-19 Exact Sciences Corporation Multiplex amplification detection assay and isolation and detection of DNA from plasma
KR102892245B1 (ko) 2017-01-27 2025-11-27 이그젝트 싸이언스 디블롭먼트 컴패니, 엘엘씨 메틸화된 dna 분석에 의한 결장 신조직형성의 검출
US10975443B2 (en) 2017-11-30 2021-04-13 Mayo Foundation For Medical Education And Research Detecting breast cancer
US10648025B2 (en) 2017-12-13 2020-05-12 Exact Sciences Development Company, Llc Multiplex amplification detection assay II
US12584177B2 (en) 2019-01-24 2026-03-24 Mayo Foundation For Medical Education And Research Detecting endometrial cancer
CA3154354A1 (en) 2019-10-31 2021-05-06 William R. Taylor Detecting ovarian cancer
CN113122636A (zh) * 2020-01-14 2021-07-16 上海鹍远生物技术有限公司 检测dna甲基化的试剂及用途
CN111370129B (zh) * 2020-04-20 2021-06-08 上海鹍远生物技术有限公司 甲状腺肿瘤良恶性鉴别模型及其应用
EP4146678A4 (en) * 2020-05-04 2025-08-27 Mayo Found Medical Education & Res DETECTION OF PANCREATIC NEUROENDOCRINE TUMORS
WO2021237103A1 (en) 2020-05-22 2021-11-25 Wisconsin Alumni Research Foundation Epigenetic modification of select genes as markers of hypersomnolence
CN112779334B (zh) * 2021-02-01 2022-05-27 杭州医学院 一种用于前列腺癌早期筛查的甲基化标志物组合及筛选方法
KR20230105973A (ko) * 2022-01-05 2023-07-12 주식회사 젠큐릭스 특정 유전자의 CpG 메틸화 변화를 이용한 전립선암 진단용 조성물 및 이의 용도
CN116287227B (zh) * 2022-09-26 2024-11-05 武汉艾米森生命科技有限公司 用于诊断前列腺癌的试剂和试剂盒
US20250270650A1 (en) * 2023-12-12 2025-08-28 Flagship Pioneering Innovations Vi, Llc Methods for identifying genomic regions of low background methylation
CN118685521A (zh) * 2024-08-26 2024-09-24 湖南宏雅基因技术有限公司 一种用于前列腺癌检测的引物探针组合物及其应用
CN120005997B (zh) * 2025-01-10 2025-09-09 中南大学湘雅三医院 前列腺癌特异性甲基化标志物的应用和检测试剂

Family Cites Families (118)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1016854A (en) * 1909-10-12 1912-02-06 Nat Malleable Castings Co Uncoupling mechanism for car-couplings.
US5288609A (en) 1984-04-27 1994-02-22 Enzo Diagnostics, Inc. Capture sandwich hybridization method and composition
US4965188A (en) 1986-08-22 1990-10-23 Cetus Corporation Process for amplifying, detecting, and/or cloning nucleic acid sequences using a thermostable enzyme
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US5011769A (en) 1985-12-05 1991-04-30 Meiogenics U.S. Limited Partnership Methods for detecting nucleic acid sequences
US5541308A (en) 1986-11-24 1996-07-30 Gen-Probe Incorporated Nucleic acid probes for detection and/or quantitation of non-viral organisms
US5359100A (en) 1987-10-15 1994-10-25 Chiron Corporation Bifunctional blocked phosphoramidites useful in making nucleic acid mutimers
US5124246A (en) 1987-10-15 1992-06-23 Chiron Corporation Nucleic acid multimers and amplified nucleic acid hybridization assays using same
US5403711A (en) 1987-11-30 1995-04-04 University Of Iowa Research Foundation Nucleic acid hybridization and amplification method for detection of specific sequences in which a complementary labeled nucleic acid probe is cleaved
CA1340807C (en) 1988-02-24 1999-11-02 Lawrence T. Malek Nucleic acid amplification process
US5639611A (en) 1988-12-12 1997-06-17 City Of Hope Allele specific polymerase chain reaction
US6677312B1 (en) 1989-03-29 2004-01-13 The Johns Hopkins University Methods for restoring wild-type p53 gene function
US5362623A (en) 1991-06-14 1994-11-08 The John Hopkins University Sequence specific DNA binding by p53
US6800617B1 (en) 1989-03-29 2004-10-05 The Johns Hopkins University Methods for restoring wild-type p53 gene function
US5527676A (en) 1989-03-29 1996-06-18 The Johns Hopkins University Detection of loss of the wild-type P53 gene and kits therefor
CA2036946C (en) 1990-04-06 2001-10-16 Kenneth V. Deugau Indexing linkers
US5494810A (en) 1990-05-03 1996-02-27 Cornell Research Foundation, Inc. Thermostable ligase-mediated DNA amplifications system for the detection of genetic disease
US5849481A (en) 1990-07-27 1998-12-15 Chiron Corporation Nucleic acid hybridization assays employing large comb-type branched polynucleotides
US5352775A (en) 1991-01-16 1994-10-04 The Johns Hopkins Univ. APC gene and nucleic acid probes derived therefrom
US6872816B1 (en) 1996-01-24 2005-03-29 Third Wave Technologies, Inc. Nucleic acid detection kits
US5994069A (en) 1996-01-24 1999-11-30 Third Wave Technologies, Inc. Detection of nucleic acids by multiple sequential invasive cleavages
US5846717A (en) 1996-01-24 1998-12-08 Third Wave Technologies, Inc. Detection of nucleic acid sequences by invader-directed cleavage
US5338671A (en) 1992-10-07 1994-08-16 Eastman Kodak Company DNA amplification with thermostable DNA polymerase and polymerase inhibiting antibody
SE501439C2 (sv) 1993-06-22 1995-02-13 Pharmacia Lkb Biotech Sätt och anordning för analys av polynukleotidsekvenser
US6235470B1 (en) 1993-11-12 2001-05-22 The Johns Hopkins University School Of Medicine Detection of neoplasia by analysis of saliva
WO1995014106A2 (en) 1993-11-17 1995-05-26 Id Biomedical Corporation Cycling probe cleavage detection of nucleic acid sequences
AU1061395A (en) 1993-11-30 1995-06-19 Mcgill University Inhibition of dna methyltransferase
AU693198B2 (en) 1994-04-25 1998-06-25 Avitech Diagnostics, Inc. Detection of mutation by resolvase cleavage
US5851770A (en) 1994-04-25 1998-12-22 Variagenics, Inc. Detection of mismatches by resolvase cleavage using a magnetic bead support
WO1996020287A2 (en) 1994-12-23 1996-07-04 Behringwerke Aktiengesellschaft Detection of nucleic acids by target-catalyzed product formation
US5882867A (en) 1995-06-07 1999-03-16 Dade Behring Marburg Gmbh Detection of nucleic acids by formation of template-dependent product
US5773258A (en) 1995-08-25 1998-06-30 Roche Molecular Systems, Inc. Nucleic acid amplification using a reversibly inactivated thermostable enzyme
US5854033A (en) 1995-11-21 1998-12-29 Yale University Rolling circle replication reporter systems
US5965408A (en) 1996-07-09 1999-10-12 Diversa Corporation Method of DNA reassembly by interrupting synthesis
US5670325A (en) 1996-08-14 1997-09-23 Exact Laboratories, Inc. Method for the detection of clonal populations of transformed cells in a genomically heterogeneous cellular sample
JP2001517925A (ja) 1995-12-22 2001-10-09 ベーリングウエルケ、アクティエンゲゼルシャフト 核酸の均質増幅および検出
US5985557A (en) 1996-01-24 1999-11-16 Third Wave Technologies, Inc. Invasive cleavage of nucleic acids
US5741650A (en) 1996-01-30 1998-04-21 Exact Laboratories, Inc. Methods for detecting colon cancer from stool samples
US5891651A (en) 1996-03-29 1999-04-06 Mayo Foundation For Medical Education And Research Methods of recovering colorectal epithelial cells or fragments thereof from stool
EP0892808B1 (en) 1996-04-12 2008-05-14 PHRI Properties, Inc. Detection probes, kits and assays
US6017704A (en) 1996-06-03 2000-01-25 The Johns Hopkins University School Of Medicine Method of detection of methylated nucleic acid using agents which modify unmethylated cytosine and distinguishing modified methylated and non-methylated nucleic acids
US5786146A (en) 1996-06-03 1998-07-28 The Johns Hopkins University School Of Medicine Method of detection of methylated nucleic acid using agents which modify unmethylated cytosine and distinguishing modified methylated and non-methylated nucleic acids
US6020137A (en) 1996-08-14 2000-02-01 Exact Laboratories, Inc. Methods for the detection of loss of heterozygosity
US5928870A (en) 1997-06-16 1999-07-27 Exact Laboratories, Inc. Methods for the detection of loss of heterozygosity
US5952178A (en) 1996-08-14 1999-09-14 Exact Laboratories Methods for disease diagnosis from stool samples
US6096273A (en) 1996-11-05 2000-08-01 Clinical Micro Sensors Electrodes linked via conductive oligomers to nucleic acids
US6251594B1 (en) 1997-06-09 2001-06-26 Usc/Norris Comprehensive Cancer Ctr. Cancer diagnostic method based upon DNA methylation differences
US6013459A (en) 1997-06-12 2000-01-11 Clinical Micro Sensors, Inc. Detection of analytes using reorganization energy
DE19754482A1 (de) 1997-11-27 1999-07-01 Epigenomics Gmbh Verfahren zur Herstellung komplexer DNA-Methylierungs-Fingerabdrücke
US6063573A (en) 1998-01-27 2000-05-16 Clinical Micro Sensors, Inc. Cycling probe technology using electron transfer detection
AU753273B2 (en) 1998-02-04 2002-10-10 Variagenics, Inc. Mismatch detection techniques
US6235502B1 (en) 1998-09-18 2001-05-22 Molecular Staging Inc. Methods for selectively isolating DNA using rolling circle amplification
US7700324B1 (en) 1998-11-03 2010-04-20 The Johns Hopkins University School Of Medicine Methylated CpG island amplification (MCA)
US6335193B1 (en) 1999-04-15 2002-01-01 Padmanabhan P Nair Isolated colonocytes
WO2001042781A2 (en) 1999-12-07 2001-06-14 Exact Sciences Corporation Supracolonic aerodigestive neoplasm detection
WO2002000926A2 (en) 2000-06-30 2002-01-03 Epigenomics Ag Diagnosis of diseases associated with signal transduction
EP1942197A1 (de) 2000-09-01 2008-07-09 Epigenomics AG Verfahren zur Bestimmung des Methylierungsgrades von bestimmten Cytosinen in genomischer DNA im Sequenzkontext 5'-CpG-3'
AU2002342004A1 (en) 2001-10-05 2003-04-22 Case Western Reserve University Methods and compositions for detecting colon cancers
EP1497462A4 (en) 2002-03-07 2007-11-07 Univ Johns Hopkins Med GENOMIC SCREEN ON EPIGENETIC MUTED CANCER ASSOCIATED GENES
US7662594B2 (en) 2002-09-20 2010-02-16 New England Biolabs, Inc. Helicase-dependent amplification of RNA
US20040146868A1 (en) 2003-01-24 2004-07-29 Epigenomics Ag Methods and nucleic acids for the analysis of CpG dinucleotide methylation status associated with the development of peripheral zone prostate cancer
CA2519456A1 (en) 2003-03-17 2004-09-30 Michael G. Goggins Aberrantly methylated genes in pancreatic cancer
EP2345745A1 (en) 2003-06-23 2011-07-20 Epigenomics AG Methods and nucleic acids for analyses of colorectal cell proliferative disorders
WO2005017207A2 (en) 2003-08-14 2005-02-24 Case Western Reserve University Methods and compositions for detecting colon cancers
US8346482B2 (en) 2003-08-22 2013-01-01 Fernandez Dennis S Integrated biosensor and simulation system for diagnosis and therapy
DE602004018801D1 (de) * 2003-09-04 2009-02-12 Human Genetic Signatures Pty Nukleinsäurenachweistest
EP2354253A3 (en) 2003-09-05 2011-11-16 Trustees of Boston University Method for non-invasive prenatal diagnosis
US20080039413A1 (en) 2003-10-21 2008-02-14 Morris David W Novel compositions and methods in cancer
SI3296407T1 (sl) 2004-03-02 2019-09-30 The Johns Hopkins University Mutacije gena PIK3CA pri rakih pri ljudeh
US20100273151A1 (en) * 2004-05-28 2010-10-28 Fred Hutchinson Cancer Research Center Genome-wide analysis of palindrome formation and dna methylation
US8114587B2 (en) 2005-06-23 2012-02-14 Ambergen, Inc. Methods for the detection of colorectal cancer
US7851154B2 (en) 2005-07-22 2010-12-14 Simon Daniel Spivack GC tag-modified bisulfite genomic DNA sequencing for continuous methylation spectra
US20090191548A1 (en) * 2005-09-29 2009-07-30 Epigenomics Ag Methods and nucleic acids for the analysis of gene expression associated with tissue classification
TR201910868T4 (tr) 2006-02-02 2019-08-21 Univ Leland Stanford Junior Dijital analizle invazif olmayan fetal genetik tarama.
JP4490382B2 (ja) 2006-02-28 2010-06-23 富士フイルム株式会社 感熱転写受像シートおよびその製造方法
WO2007116417A1 (en) 2006-04-07 2007-10-18 Silvia Sabbioni Novel dna methylation markers useful for the diagnosis of neoplastic diseases
EP2021515A4 (en) 2006-05-26 2010-06-02 Meltzer Stephen J METHYLATED PROMOTERS AS BIOMARKERS OF COLON CANCER
GB0700374D0 (en) 2007-01-09 2007-02-14 Oncomethylome Sciences S A NDRG family methylation markers
US20080213870A1 (en) 2007-03-01 2008-09-04 Sean Wuxiong Cao Methods for obtaining modified DNA from a biological specimen
CN101353695B (zh) 2007-07-23 2013-05-01 上海市肿瘤研究所 尿沉淀dna甲基化谱式分析诊断膀胱癌的方法和试剂盒
EP2816122A1 (en) 2008-02-15 2014-12-24 Mayo Foundation For Medical Education And Research Detecting neoplasm from a stool sample
WO2009117327A2 (en) 2008-03-15 2009-09-24 Hologic, Inc. Compositions and methods for analysis of nucleic acid molecules during amplification reactions
WO2010062914A1 (en) 2008-11-26 2010-06-03 The Johns Hopkins University Methods for identifying cancer risk
WO2010074924A1 (en) 2008-12-23 2010-07-01 University Of Utah Research Foundation Identification and regulation of a novel dna demethylase system
EP2233590A1 (en) 2009-01-28 2010-09-29 AIT Austrian Institute of Technology GmbH Methylation assay
DK2394170T3 (en) 2009-02-03 2015-07-13 Mdxhealth Sa Methods for detecting colorectal cancer
WO2010113529A1 (ja) 2009-04-03 2010-10-07 国立大学法人山口大学 大腸腫瘍の検出方法
WO2011037936A2 (en) * 2009-09-24 2011-03-31 Oregon Health & Science University Detection of dna methylation of tal1, erg and/or cd40 to diagnose prostate cancer
US20120164110A1 (en) 2009-10-14 2012-06-28 Feinberg Andrew P Differentially methylated regions of reprogrammed induced pluripotent stem cells, method and compositions thereof
US8709736B2 (en) 2010-07-09 2014-04-29 Medical Research Council Biomarker for Barrett's Oesophagus
US20110236916A1 (en) 2010-03-26 2011-09-29 Mayo Foundation For Medical Education And Research Methods and materials for detecting colorectal neoplasm
WO2011126768A2 (en) 2010-03-29 2011-10-13 Mayo Foundation For Medical Education And Research Methods and materials for detecting colorectal cancer and adenoma
EP2407555A1 (en) * 2010-07-14 2012-01-18 Fundació Institut de Recerca Hospital Universitari Vall d'Hebron, Fundació Privada Methods and kits for the diagnosis of prostate cancer
WO2012047899A2 (en) 2010-10-04 2012-04-12 The Johns Hopkins University Novel dna hypermethylation diagnostic biomarkers for colorectal cancer
US8715937B2 (en) 2010-11-15 2014-05-06 Exact Sciences Corporation Mutation detection assay
US8361720B2 (en) 2010-11-15 2013-01-29 Exact Sciences Corporation Real time cleavage assay
US8916344B2 (en) 2010-11-15 2014-12-23 Exact Sciences Corporation Methylation assay
EP2655664A2 (en) 2010-12-21 2013-10-30 Sloan-Kettering Institute for Cancer Research Epigenomic markers of cancer metastasis
US20140057262A1 (en) 2011-03-14 2014-02-27 Mayo Foundation For Medical Education And Research Methods and materials for using the contents of phagocytes to detect neoplasms
US8993341B2 (en) 2011-05-12 2015-03-31 Exact Sciences Corporation Removal of PCR inhibitors
US8808990B2 (en) 2011-05-12 2014-08-19 Exact Sciences Corporation Serial isolation of multiple DNA targets from stool
CN103649298A (zh) 2011-05-12 2014-03-19 精密科学公司 核酸的分离
US8980107B2 (en) 2011-05-12 2015-03-17 Exact Sciences Corporation Spin filter
WO2012167145A2 (en) 2011-06-01 2012-12-06 University Of Southern California Genome-scale analysis of aberrant dna methylation in colorectal cancer
US20130022974A1 (en) * 2011-06-17 2013-01-24 The Regents Of The University Of Michigan Dna methylation profiles in cancer
WO2012175562A2 (en) 2011-06-21 2012-12-27 University Of Tartu Methylation and microrna markers of early-stage non-small cell lung cancer
KR20140100938A (ko) 2011-11-30 2014-08-18 도쿠리츠교세이호진 고쿠리츠간켄큐센터 유도 악성 줄기세포
WO2013130880A1 (en) 2012-02-28 2013-09-06 The Johns Hopkins University Hypermethylated gene markers for head and neck cancer
CA2865087A1 (en) 2012-03-15 2013-09-19 Mayo Foundation For Medical Education And Research Methods and materials for noninvasive detection of colorectal neoplasia associated with inflammatory bowel disease
US10106854B2 (en) * 2012-06-14 2018-10-23 Aarhus Universitet Biomarkers for prostate cancer
US10233495B2 (en) 2012-09-27 2019-03-19 The Hospital For Sick Children Methods and compositions for screening and treating developmental disorders
ES2859645T3 (es) 2013-03-14 2021-10-04 Mayo Found Medical Education & Res Detección de neoplasia
JP6369857B2 (ja) 2013-05-29 2018-08-08 シスメックス株式会社 肝細胞癌に関する情報の取得方法、ならびに肝細胞癌に関する情報を取得するためのマーカーおよびキット
AU2014340398A1 (en) * 2013-10-24 2016-06-09 Georgetown University Methods and compositions for treating cancer
WO2016049276A1 (en) * 2014-09-25 2016-03-31 Moffitt Genetics Corporation Prognostic tumor biomarkers
EP3034624A1 (en) 2014-12-18 2016-06-22 Hospital Clínic de Barcelona Method for the prognosis of hepatocellular carcinoma
EP3037545A1 (en) * 2014-12-23 2016-06-29 The Provost, Fellows, Foundation Scholars, & the other members of Board, of the College of the Holy & Undiv. Trinity of Queen Elizabeth near Dublin A DNA-methylation test for prostate cancer

Also Published As

Publication number Publication date
AU2024219684A1 (en) 2024-10-10
US10934592B2 (en) 2021-03-02
JP7674415B2 (ja) 2025-05-09
EP3589732A4 (en) 2021-05-19
US20180245163A1 (en) 2018-08-30
US20210130911A1 (en) 2021-05-06
AU2018229294A1 (en) 2019-09-26
CN118147307A (zh) 2024-06-07
WO2018160576A1 (en) 2018-09-07
EP3589732A1 (en) 2020-01-08
JP7356349B2 (ja) 2023-10-04
CA3054836A1 (en) 2018-09-07
US11697853B2 (en) 2023-07-11
US20230416840A1 (en) 2023-12-28
CN110431241A (zh) 2019-11-08
JP2023123530A (ja) 2023-09-05
AU2018229294B2 (en) 2024-06-13
CN110431241B (zh) 2024-04-19
KR20190140901A (ko) 2019-12-20
JP2025114618A (ja) 2025-08-05
KR102747156B1 (ko) 2024-12-26
JP2020513795A (ja) 2020-05-21

Similar Documents

Publication Publication Date Title
JP7674415B2 (ja) 前立腺癌検出
AU2022291502B2 (en) Detecting hepatocellular carcinoma
US12601011B2 (en) Detecting gastric neoplasm
US20230212691A1 (en) Detecting colorectal neoplasia
US20230028856A1 (en) Detecting gastrointestinal neoplasms
JP7799607B2 (ja) 卵巣癌の検出
US20230357852A1 (en) Detecting non-hodgkin lymphoma
HK40103516A (en) Detecting hepatocellular carcinoma

Legal Events

Date Code Title Description
A107 Divisional application of patent
PA0104 Divisional application for international application

Comment text: Divisional Application for International Patent

Patent event code: PA01041R01D

Patent event date: 20241220

Application number text: 1020197025327

Filing date: 20190828

PG1501 Laying open of application
A201 Request for examination
PA0201 Request for examination

Patent event code: PA02012R01D

Patent event date: 20250117

Comment text: Request for Examination of Application