KR20250004738A - 유전자 요법을 위한 irak4 조절제의 용도 - Google Patents

유전자 요법을 위한 irak4 조절제의 용도 Download PDF

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Publication number
KR20250004738A
KR20250004738A KR1020247037272A KR20247037272A KR20250004738A KR 20250004738 A KR20250004738 A KR 20250004738A KR 1020247037272 A KR1020247037272 A KR 1020247037272A KR 20247037272 A KR20247037272 A KR 20247037272A KR 20250004738 A KR20250004738 A KR 20250004738A
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South Korea
Prior art keywords
gene therapy
capsid
irak
aav
therapy agent
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Korean (ko)
Inventor
소우라브 로이 초우두리
모나 모트와니
크리스티안 뮐러
존 리드
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젠자임 코포레이션
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5386—1,4-Oxazines, e.g. morpholine spiro-condensed or forming part of bridged ring systems
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    • A61K48/0008—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition
    • A61K48/0025—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition wherein the non-active part clearly interacts with the delivered nucleic acid
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    • A61K48/0025—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition wherein the non-active part clearly interacts with the delivered nucleic acid
    • A61K48/0041—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition wherein the non-active part clearly interacts with the delivered nucleic acid the non-active part being polymeric
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    • A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
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    • G01N33/6863—Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
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KR1020247037272A 2022-04-12 2023-04-12 유전자 요법을 위한 irak4 조절제의 용도 Pending KR20250004738A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202263330245P 2022-04-12 2022-04-12
US63/330,245 2022-04-12
PCT/US2023/065689 WO2023201274A1 (en) 2022-04-12 2023-04-12 Use of an irak4 modulator for gene therapy

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KR20250004738A true KR20250004738A (ko) 2025-01-08

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US (1) US20230405014A1 (https=)
EP (1) EP4508226A1 (https=)
JP (1) JP2025513851A (https=)
KR (1) KR20250004738A (https=)
CN (1) CN119343458A (https=)
AU (1) AU2023253700A1 (https=)
CA (1) CA3248216A1 (https=)
IL (1) IL316222A (https=)
MX (1) MX2024012617A (https=)
TW (1) TW202402329A (https=)
WO (1) WO2023201274A1 (https=)

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PH12022500002A1 (en) 2019-06-28 2023-04-03 Kymera Therapeutics Inc Irak degraders and uses thereof
WO2021011868A1 (en) 2019-07-17 2021-01-21 Kymera Therapeutics, Inc. Irak degraders and uses thereof
WO2021119159A1 (en) 2019-12-10 2021-06-17 Kymera Therapeutics, Inc. Irak degraders and uses thereof
KR20220145325A (ko) 2019-12-17 2022-10-28 카이메라 쎄라퓨틱스 인코포레이티드 Irak 분해제 및 이의 용도
TW202535949A (zh) 2023-12-20 2025-09-16 美商必治妥美雅史谷比公司 靶向IL-18受體β(IL-18RB)之抗體及相關方法
WO2025158385A1 (en) * 2024-01-25 2025-07-31 Genzyme Corporation Pegylated il-2 for suppressing adaptive immune response to gene therapy

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