KR20250002133A - 항체-약물 접합체, 이의 약학적 조성물 및 용도 - Google Patents

항체-약물 접합체, 이의 약학적 조성물 및 용도 Download PDF

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Publication number
KR20250002133A
KR20250002133A KR1020247029208A KR20247029208A KR20250002133A KR 20250002133 A KR20250002133 A KR 20250002133A KR 1020247029208 A KR1020247029208 A KR 1020247029208A KR 20247029208 A KR20247029208 A KR 20247029208A KR 20250002133 A KR20250002133 A KR 20250002133A
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South Korea
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group
antibody
compound
μmol
preparation
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KR1020247029208A
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English (en)
Korean (ko)
Inventor
진밍 류
윈 런
팅 허
치앙 티안
홍메이 송
쥔유 거
Original Assignee
쓰촨 케룬-바이오테크 바이오파마수티컬 컴퍼니 리미티드
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Publication of KR20250002133A publication Critical patent/KR20250002133A/ko
Pending legal-status Critical Current

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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
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    • A61K47/6889—Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment
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    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
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    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
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    • C—CHEMISTRY; METALLURGY
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    • C07D—HETEROCYCLIC COMPOUNDS
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  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Cell Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
KR1020247029208A 2022-04-29 2023-04-19 항체-약물 접합체, 이의 약학적 조성물 및 용도 Pending KR20250002133A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN202210465896.5 2022-04-29
CN202210465896 2022-04-29
PCT/CN2023/089224 WO2023207710A1 (zh) 2022-04-29 2023-04-19 一类抗体药物偶联物、其药物组合物及应用

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KR20250002133A true KR20250002133A (ko) 2025-01-07

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KR1020247029208A Pending KR20250002133A (ko) 2022-04-29 2023-04-19 항체-약물 접합체, 이의 약학적 조성물 및 용도

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Country Link
US (1) US20250195683A1 (https=)
EP (1) EP4516321A1 (https=)
JP (1) JP2025513163A (https=)
KR (1) KR20250002133A (https=)
CN (1) CN118829451A (https=)
AU (1) AU2023260131A1 (https=)
CA (1) CA3253667A1 (https=)
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