CN118829451A - 一类抗体药物偶联物、其药物组合物及应用 - Google Patents

一类抗体药物偶联物、其药物组合物及应用 Download PDF

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Publication number
CN118829451A
CN118829451A CN202380024259.7A CN202380024259A CN118829451A CN 118829451 A CN118829451 A CN 118829451A CN 202380024259 A CN202380024259 A CN 202380024259A CN 118829451 A CN118829451 A CN 118829451A
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China
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compound
group
mol
preparation
antibody
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CN202380024259.7A
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Chinese (zh)
Inventor
刘金明
任云
何婷
田强
宋宏梅
葛均友
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Sichuan Kelun Biotech Biopharmaceutical Co Ltd
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Sichuan Kelun Biotech Biopharmaceutical Co Ltd
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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
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    • A61K47/6889—Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment
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  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Organic Chemistry (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Molecular Biology (AREA)
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  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
CN202380024259.7A 2022-04-29 2023-04-19 一类抗体药物偶联物、其药物组合物及应用 Pending CN118829451A (zh)

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CN2022104658965 2022-04-29
CN202210465896 2022-04-29
PCT/CN2023/089224 WO2023207710A1 (zh) 2022-04-29 2023-04-19 一类抗体药物偶联物、其药物组合物及应用

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US (1) US20250195683A1 (https=)
EP (1) EP4516321A1 (https=)
JP (1) JP2025513163A (https=)
KR (1) KR20250002133A (https=)
CN (1) CN118829451A (https=)
AU (1) AU2023260131A1 (https=)
CA (1) CA3253667A1 (https=)
MX (1) MX2024010601A (https=)
WO (1) WO2023207710A1 (https=)

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WO2024114318A1 (zh) * 2022-11-29 2024-06-06 四川科伦博泰生物医药股份有限公司 药物连接子化合物及其制备方法和用途
WO2025139993A1 (zh) * 2023-12-29 2025-07-03 四川科伦博泰生物医药股份有限公司 一类抗体药物偶联物、其药物组合物及应用
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