JP2025513163A - 抗体－薬物コンジュゲート、その医薬組成物及びその使用 - Google Patents

抗体－薬物コンジュゲート、その医薬組成物及びその使用 Download PDF

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JP2025513163A
JP2025513163A JP2024551558A JP2024551558A JP2025513163A JP 2025513163 A JP2025513163 A JP 2025513163A JP 2024551558 A JP2024551558 A JP 2024551558A JP 2024551558 A JP2024551558 A JP 2024551558A JP 2025513163 A JP2025513163 A JP 2025513163A
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group
compound
antibody
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preparation
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JP2025513163A5 (https=
Inventor
ジンミン リュー，
ユン レン，
ティン ヘ，
チアン ティエン，
ホンメイ ソン，
ジュンユー ガー，
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シチュアン ケルン－バイオテック バイオファーマシューティカル カンパニー リミテッド
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Publication of JP2025513163A publication Critical patent/JP2025513163A/ja
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6851—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell
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    • A61K47/6889—Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment
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    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
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JP2024551558A 2022-04-29 2023-04-19 抗体－薬物コンジュゲート、その医薬組成物及びその使用 Pending JP2025513163A (ja)

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CN202210465896.5 2022-04-29
CN202210465896 2022-04-29
PCT/CN2023/089224 WO2023207710A1 (zh) 2022-04-29 2023-04-19 一类抗体药物偶联物、其药物组合物及应用

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JP2025513163A5 JP2025513163A5 (https=) 2026-03-18

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US (1) US20250195683A1 (https=)
EP (1) EP4516321A1 (https=)
JP (1) JP2025513163A (https=)
KR (1) KR20250002133A (https=)
CN (1) CN118829451A (https=)
AU (1) AU2023260131A1 (https=)
CA (1) CA3253667A1 (https=)
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