KR20240155367A - 아미노피리딘 유도체 및 이의 선택적 alk-2 억제제로서의 용도 - Google Patents

아미노피리딘 유도체 및 이의 선택적 alk-2 억제제로서의 용도 Download PDF

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Publication number
KR20240155367A
KR20240155367A KR1020247034434A KR20247034434A KR20240155367A KR 20240155367 A KR20240155367 A KR 20240155367A KR 1020247034434 A KR1020247034434 A KR 1020247034434A KR 20247034434 A KR20247034434 A KR 20247034434A KR 20240155367 A KR20240155367 A KR 20240155367A
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phenyl
amino
azabicyclo
nicotinamide
hexan
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Korean (ko)
Inventor
지아량 리
루카 아리스타
스리하리 바부
지안웨이 비안
카이 쿠이
마이클 패트릭 딜런
렌 라트만
레브 리아오
디미트리오스 리조스
리타 라모스
니콜라우스 요하네스 슈티플
토마스 울리히
페기 유셀만
시아오양 왕
릴라드하르 무를리드하르 웨이콜
스벤 바일러
유보 장
이종 조우
팅잉 주
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노파르티스 아게
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    • A—HUMAN NECESSITIES
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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KR1020247034434A 2016-07-20 2017-07-18 아미노피리딘 유도체 및 이의 선택적 alk-2 억제제로서의 용도 Pending KR20240155367A (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201662364620P 2016-07-20 2016-07-20
US62/364,620 2016-07-20
PCT/CN2017/093385 WO2018014829A1 (en) 2016-07-20 2017-07-18 Aminopyridine derivatives and their use as selective alk-2 inhibitors
KR1020247016068A KR102719881B1 (ko) 2016-07-20 2017-07-18 아미노피리딘 유도체 및 이의 선택적 alk-2 억제제로서의 용도

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KR1020247016068A Division KR102719881B1 (ko) 2016-07-20 2017-07-18 아미노피리딘 유도체 및 이의 선택적 alk-2 억제제로서의 용도

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KR1020247034434A Pending KR20240155367A (ko) 2016-07-20 2017-07-18 아미노피리딘 유도체 및 이의 선택적 alk-2 억제제로서의 용도
KR1020197004529A Active KR102281550B1 (ko) 2016-07-20 2017-07-18 아미노피리딘 유도체 및 이의 선택적 alk-2 억제제로서의 용도
KR1020227003660A Active KR102454129B1 (ko) 2016-07-20 2017-07-18 아미노피리딘 유도체 및 이의 선택적 alk-2 억제제로서의 용도
KR1020237024969A Active KR102667331B1 (ko) 2016-07-20 2017-07-18 아미노피리딘 유도체 및 이의 선택적 alk-2 억제제로서의 용도
KR1020217022916A Active KR102359707B1 (ko) 2016-07-20 2017-07-18 아미노피리딘 유도체 및 이의 선택적 alk-2 억제제로서의 용도
KR1020247016068A Active KR102719881B1 (ko) 2016-07-20 2017-07-18 아미노피리딘 유도체 및 이의 선택적 alk-2 억제제로서의 용도
KR1020227034980A Active KR102559539B1 (ko) 2016-07-20 2017-07-18 아미노피리딘 유도체 및 이의 선택적 alk-2 억제제로서의 용도

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KR1020197004529A Active KR102281550B1 (ko) 2016-07-20 2017-07-18 아미노피리딘 유도체 및 이의 선택적 alk-2 억제제로서의 용도
KR1020227003660A Active KR102454129B1 (ko) 2016-07-20 2017-07-18 아미노피리딘 유도체 및 이의 선택적 alk-2 억제제로서의 용도
KR1020237024969A Active KR102667331B1 (ko) 2016-07-20 2017-07-18 아미노피리딘 유도체 및 이의 선택적 alk-2 억제제로서의 용도
KR1020217022916A Active KR102359707B1 (ko) 2016-07-20 2017-07-18 아미노피리딘 유도체 및 이의 선택적 alk-2 억제제로서의 용도
KR1020247016068A Active KR102719881B1 (ko) 2016-07-20 2017-07-18 아미노피리딘 유도체 및 이의 선택적 alk-2 억제제로서의 용도
KR1020227034980A Active KR102559539B1 (ko) 2016-07-20 2017-07-18 아미노피리딘 유도체 및 이의 선택적 alk-2 억제제로서의 용도

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US10710980B2 (en) * 2016-07-20 2020-07-14 Novartis Ag Aminopyridine derivatives and their use as selective ALK-2 inhibitors
CN115038443A (zh) 2019-11-22 2022-09-09 因西特公司 包含alk2抑制剂和jak2抑制剂的组合疗法
CN111170893B (zh) * 2020-01-19 2022-04-26 郑州依米花手性药物研究有限公司 Lefamulin的中间体化合物及其在Lefamulin制备中的应用
JP2023530316A (ja) 2020-06-16 2023-07-14 インサイト・コーポレイション 貧血の治療のためのａｌｋ２阻害剤
KR102913358B1 (ko) * 2020-10-29 2026-01-14 주식회사 엘지화학 중수소화 화합물의 분석방법, 소자 제조용 중수소화 화합물의 선별방법 및 전자 소자의 제조방법
US12115154B2 (en) 2020-12-16 2024-10-15 Srx Cardio, Llc Compounds for the modulation of proprotein convertase subtilisin/kexin type 9 (PCSK9)
CN116478145B (zh) * 2022-04-13 2024-02-02 杭州邦顺制药有限公司 Alk2激酶抑制剂

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