JP7030776B2 - アミノピリジン誘導体およびそれらの選択的ａｌｋ－２阻害剤としての使用 - Google Patents

アミノピリジン誘導体およびそれらの選択的ａｌｋ－２阻害剤としての使用 Download PDF

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JP7030776B2
JP7030776B2 JP2019502675A JP2019502675A JP7030776B2 JP 7030776 B2 JP7030776 B2 JP 7030776B2 JP 2019502675 A JP2019502675 A JP 2019502675A JP 2019502675 A JP2019502675 A JP 2019502675A JP 7030776 B2 JP7030776 B2 JP 7030776B2
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amino
phenyl
nicotinamide
azabicyclo
hexane
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JP2019521167A (ja
JP2019521167A5 (https=
Inventor
リ，ジャリアン
アリスタ，ルカ
バブ，スリーハリ
ビアン，ジャンウェイ
クイ，カイ
パトリック ディロン，マイケル
ラットマン，レーン
リャオ，エルブイ
リゾ，ディミトリオス
ラモス，リタ
ヨハネス スティーフル，ニコラス
ウルリッヒ，トーマス
ユッセルマン，ペギー
ワン，シャオヤン
マーリダー ウェイコール，リラダール
ウェイラー，スヴェン
ツァン，ユボ
チョウ，イツォン
チュ，ティンイン
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ノバルティス アーゲー
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Priority to JP2023048083A priority patent/JP7584553B2/ja
Priority to JP2024193634A priority patent/JP7834830B2/ja
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • C—CHEMISTRY; METALLURGY
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    • A—HUMAN NECESSITIES
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C07D213/82—Amides; Imides in position 3
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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
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    • C07D411/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing three or more hetero rings
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    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
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    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
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    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
JP2019502675A 2016-07-20 2017-07-18 アミノピリジン誘導体およびそれらの選択的ａｌｋ－２阻害剤としての使用 Active JP7030776B2 (ja)

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JP2022025894A JP7253086B2 (ja) 2016-07-20 2022-02-22 アミノピリジン誘導体およびそれらの選択的ａｌｋ－２阻害剤としての使用
JP2023048083A JP7584553B2 (ja) 2016-07-20 2023-03-24 アミノピリジン誘導体およびそれらの選択的ａｌｋ－２阻害剤としての使用
JP2024193634A JP7834830B2 (ja) 2016-07-20 2024-11-05 アミノピリジン誘導体およびそれらの選択的ａｌｋ－２阻害剤としての使用

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US201662364620P 2016-07-20 2016-07-20
US62/364,620 2016-07-20
PCT/CN2017/093385 WO2018014829A1 (en) 2016-07-20 2017-07-18 Aminopyridine derivatives and their use as selective alk-2 inhibitors

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JP2019521167A JP2019521167A (ja) 2019-07-25
JP2019521167A5 JP2019521167A5 (https=) 2020-08-27
JP7030776B2 true JP7030776B2 (ja) 2022-03-07

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JP2019502675A Active JP7030776B2 (ja) 2016-07-20 2017-07-18 アミノピリジン誘導体およびそれらの選択的ａｌｋ－２阻害剤としての使用
JP2022025894A Active JP7253086B2 (ja) 2016-07-20 2022-02-22 アミノピリジン誘導体およびそれらの選択的ａｌｋ－２阻害剤としての使用
JP2023048083A Active JP7584553B2 (ja) 2016-07-20 2023-03-24 アミノピリジン誘導体およびそれらの選択的ａｌｋ－２阻害剤としての使用
JP2024193634A Active JP7834830B2 (ja) 2016-07-20 2024-11-05 アミノピリジン誘導体およびそれらの選択的ａｌｋ－２阻害剤としての使用

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JP2023048083A Active JP7584553B2 (ja) 2016-07-20 2023-03-24 アミノピリジン誘導体およびそれらの選択的ａｌｋ－２阻害剤としての使用
JP2024193634A Active JP7834830B2 (ja) 2016-07-20 2024-11-05 アミノピリジン誘導体およびそれらの選択的ａｌｋ－２阻害剤としての使用

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US (3) US10710980B2 (https=)
EP (3) EP3487851B1 (https=)
JP (4) JP7030776B2 (https=)
KR (7) KR20240155367A (https=)
CN (2) CN109641871B (https=)
AR (1) AR109108A1 (https=)
AU (5) AU2017298187B2 (https=)
CY (1) CY1124967T1 (https=)
DK (2) DK3487851T3 (https=)
EA (2) EA037520B1 (https=)
ES (2) ES2984746T3 (https=)
FI (1) FI3971177T3 (https=)
HR (2) HRP20241015T1 (https=)
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PT (2) PT3971177T (https=)
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US10710980B2 (en) * 2016-07-20 2020-07-14 Novartis Ag Aminopyridine derivatives and their use as selective ALK-2 inhibitors
CN115038443A (zh) 2019-11-22 2022-09-09 因西特公司 包含alk2抑制剂和jak2抑制剂的组合疗法
CN111170893B (zh) * 2020-01-19 2022-04-26 郑州依米花手性药物研究有限公司 Lefamulin的中间体化合物及其在Lefamulin制备中的应用
JP2023530316A (ja) 2020-06-16 2023-07-14 インサイト・コーポレイション 貧血の治療のためのａｌｋ２阻害剤
KR102913358B1 (ko) * 2020-10-29 2026-01-14 주식회사 엘지화학 중수소화 화합물의 분석방법, 소자 제조용 중수소화 화합물의 선별방법 및 전자 소자의 제조방법
US12115154B2 (en) 2020-12-16 2024-10-15 Srx Cardio, Llc Compounds for the modulation of proprotein convertase subtilisin/kexin type 9 (PCSK9)
CN116478145B (zh) * 2022-04-13 2024-02-02 杭州邦顺制药有限公司 Alk2激酶抑制剂

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JP2015531371A (ja) 2012-09-28 2015-11-02 ヴァンダービルト ユニバーシティーＶａｎｄｅｒｂｉｌｔ Ｕｎｉｖｅｒｓｉｔｙ 選択的ｂｍｐ阻害剤としての縮合複素環化合物
JP2016510745A (ja) 2013-03-04 2016-04-11 ザ ブリガム アンド ウィメンズ ホスピタル インコーポレイテッドＴｈｅ Ｂｒｉｇｈａｍ ａｎｄ Ｗｏｍｅｎ’ｓ Ｈｏｓｐｉｔａｌ， Ｉｎｃ． Ｂｍｐ阻害剤およびその使用方法
JP2016513661A (ja) 2013-03-14 2016-05-16 トレロ ファーマシューティカルズ， インコーポレイテッド Ｊａｋ２およびａｌｋ２阻害剤およびその使用方法

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