KR20240150464A - 뉴로텐신 수용체를 표적화하기 위한 화합물 및 방사선리간드 및 이의 용도 - Google Patents
뉴로텐신 수용체를 표적화하기 위한 화합물 및 방사선리간드 및 이의 용도 Download PDFInfo
- Publication number
- KR20240150464A KR20240150464A KR1020247030010A KR20247030010A KR20240150464A KR 20240150464 A KR20240150464 A KR 20240150464A KR 1020247030010 A KR1020247030010 A KR 1020247030010A KR 20247030010 A KR20247030010 A KR 20247030010A KR 20240150464 A KR20240150464 A KR 20240150464A
- Authority
- KR
- South Korea
- Prior art keywords
- compound
- alkyl
- alkylene
- groups
- pharmaceutically acceptable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
- A61K51/0482—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group chelates from cyclic ligands, e.g. DOTA
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0497—Organic compounds conjugates with a carrier being an organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Optics & Photonics (AREA)
- Physics & Mathematics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202263311621P | 2022-02-18 | 2022-02-18 | |
| US63/311,621 | 2022-02-18 | ||
| PCT/US2023/013314 WO2023158802A1 (en) | 2022-02-18 | 2023-02-17 | Compounds and radioligands for targeting neurotensin receptor and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20240150464A true KR20240150464A (ko) | 2024-10-15 |
Family
ID=87579080
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020247030010A Pending KR20240150464A (ko) | 2022-02-18 | 2023-02-17 | 뉴로텐신 수용체를 표적화하기 위한 화합물 및 방사선리간드 및 이의 용도 |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US12145926B2 (enExample) |
| EP (1) | EP4479040A1 (enExample) |
| JP (1) | JP2025506705A (enExample) |
| KR (1) | KR20240150464A (enExample) |
| CN (1) | CN119136796A (enExample) |
| AU (1) | AU2023221977A1 (enExample) |
| CA (1) | CA3243418A1 (enExample) |
| CL (1) | CL2024002422A1 (enExample) |
| IL (1) | IL314786A (enExample) |
| MX (1) | MX2024009858A (enExample) |
| WO (1) | WO2023158802A1 (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2023158802A1 (en) | 2022-02-18 | 2023-08-24 | Full-Life Technologies U.S. Inc. | Compounds and radioligands for targeting neurotensin receptor and uses thereof |
| WO2025146126A1 (en) * | 2024-01-04 | 2025-07-10 | Full-Life Technologies Hk Limited | Preparation method of compounds targeting neurotensin receptor |
| JP2026106435A (ja) * | 2024-12-17 | 2026-06-29 | イーライ リリー アンド カンパニー | ニューロテンシン受容体リガンド |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5021556A (en) | 1987-07-22 | 1991-06-04 | Neorx Corporation | Method of radiolabeling chelating compounds comprising sulfur atoms with metal radionuclides |
| US5075099A (en) | 1988-05-31 | 1991-12-24 | Neorx Corporation | Metal radionuclide chelating compounds for improved chelation kinetics |
| US5364613A (en) | 1989-04-07 | 1994-11-15 | Sieving Paul F | Polychelants containing macrocyclic chelant moieties |
| US5367080A (en) | 1990-11-08 | 1994-11-22 | Sterling Winthrop Inc. | Complexing agents and targeting radioactive immunoreagents useful in therapeutic and diagnostic imaging compositions and methods |
| DE4307983A1 (de) | 1993-03-13 | 1994-09-15 | Beiersdorf Ag | Wirkstoffe und kosmetische und dermatologische Zubereitungen |
| FR2732967B1 (fr) | 1995-04-11 | 1997-07-04 | Sanofi Sa | 1-phenylpyrazole-3-carboxamides substitues, actifs sur la neurotensine, leur preparation, les compositions pharmaceutiques en contenant |
| US5886142A (en) | 1997-05-20 | 1999-03-23 | Thomas Jefferson University | Radiolabeled thrombus imaging agents |
| EP2740726A1 (en) * | 2012-12-07 | 2014-06-11 | 3B Pharmaceuticals GmbH | Neurotensin receptor ligands |
| CA2949936C (en) | 2014-06-10 | 2022-10-18 | 3B Pharmaceuticals Gmbh | Conjugate comprising a neurotensin receptor ligand and use thereof |
| EP3279197A1 (en) | 2016-08-03 | 2018-02-07 | Friedrich-Alexander-Universität Erlangen-Nürnberg | Diagnosis, treatment and prevention of neurotensin receptor-related conditions |
| WO2023158802A1 (en) | 2022-02-18 | 2023-08-24 | Full-Life Technologies U.S. Inc. | Compounds and radioligands for targeting neurotensin receptor and uses thereof |
-
2023
- 2023-02-17 WO PCT/US2023/013314 patent/WO2023158802A1/en not_active Ceased
- 2023-02-17 AU AU2023221977A patent/AU2023221977A1/en active Pending
- 2023-02-17 IL IL314786A patent/IL314786A/en unknown
- 2023-02-17 JP JP2024548610A patent/JP2025506705A/ja active Pending
- 2023-02-17 KR KR1020247030010A patent/KR20240150464A/ko active Pending
- 2023-02-17 CA CA3243418A patent/CA3243418A1/en active Pending
- 2023-02-17 CN CN202380034728.3A patent/CN119136796A/zh active Pending
- 2023-02-17 EP EP23756915.7A patent/EP4479040A1/en active Pending
-
2024
- 2024-03-13 US US18/604,397 patent/US12145926B2/en active Active
- 2024-08-12 MX MX2024009858A patent/MX2024009858A/es unknown
- 2024-08-13 CL CL2024002422A patent/CL2024002422A1/es unknown
- 2024-09-25 US US18/895,915 patent/US20250026739A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| IL314786A (en) | 2024-10-01 |
| WO2023158802A1 (en) | 2023-08-24 |
| CA3243418A1 (en) | 2023-08-24 |
| US20240287046A1 (en) | 2024-08-29 |
| CL2024002422A1 (es) | 2024-12-06 |
| AU2023221977A1 (en) | 2024-08-15 |
| US20250026739A1 (en) | 2025-01-23 |
| EP4479040A1 (en) | 2024-12-25 |
| MX2024009858A (es) | 2024-11-08 |
| US12145926B2 (en) | 2024-11-19 |
| CN119136796A (zh) | 2024-12-13 |
| JP2025506705A (ja) | 2025-03-13 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AU2023201120B2 (en) | FAP inhibitor | |
| TWI657827B (zh) | 用於正子斷層掃描之化合物 | |
| US12145926B2 (en) | Compounds and radioligands for targeting neurotensin receptor and uses thereof | |
| AU2022219525B2 (en) | Bivalent fibroblast activation protein ligands for targeted delivery applications | |
| JP6707677B2 (ja) | トリアジン系放射性医薬品及び放射線造影剤 | |
| EP4436979A1 (en) | Cleavable radioligands for targeting cell surface receptors and uses thereof | |
| KR20230165818A (ko) | 섬유아세포 활성화 단백질 알파 및/또는 전립선-특이적 막 항원을 표적화하는 이종이가 및 동형이가 제제 | |
| CN113166054A (zh) | 成像剂 | |
| CN115505032B (zh) | 一种成纤维细胞活化蛋白FAP和整合素αvβ3双重靶向化合物及其制备方法和应用 | |
| JP2016501238A (ja) | ニューロテンシン受容体リガンド | |
| TWI893557B (zh) | 一種靶向sstr2的化合物及其製備方法和應用 | |
| WO2019151384A1 (ja) | 放射性医薬 | |
| WO2020009093A1 (ja) | Ｃｘｃｒ４結合性化合物もしくはその塩またはそれらと金属との錯体 | |
| AU2019338221A1 (en) | CXCR4-targeted diagnostic and therapeutic agents with reduced species selectivity | |
| TW202428306A (zh) | 神經肽y1受體(npy1r)靶向治療劑及其用途 | |
| HK40114422A (en) | Compounds and radioligands for targeting neurotensin receptor and uses thereof | |
| WO2024083224A1 (en) | Dual receptor targeting radioligands and uses thereof related applications | |
| RU2838403C1 (ru) | СОЕДИНЕНИЕ ДВОЙНОГО НАЦЕЛИВАНИЯ ДЛЯ БЕЛКА АКТИВАЦИИ ФИБРОБЛАСТОВ (FAP) И ИНТЕГРИНА αvβ3, СПОСОБ ЕГО ПОЛУЧЕНИЯ И ЕГО ПРИМЕНЕНИЕ | |
| JP2025537251A (ja) | 癌の放射線イメージングおよび治療のための化合物 | |
| HK40111230A (en) | Cleavable radioligands for targeting cell surface receptors and uses thereof | |
| CN116375709A (zh) | 一种叶酸受体靶向药物、金属络合物及其制备方法与用途 | |
| WO2026086847A1 (zh) | 环肽偶联药物和应用 | |
| WO2011124713A1 (en) | Labelled huprine derivatives and their use in medical imaging |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PA0105 | International application |
St.27 status event code: A-0-1-A10-A15-nap-PA0105 |
|
| P11-X000 | Amendment of application requested |
St.27 status event code: A-2-2-P10-P11-nap-X000 |
|
| P13-X000 | Application amended |
St.27 status event code: A-2-2-P10-P13-nap-X000 |
|
| PG1501 | Laying open of application |
St.27 status event code: A-1-1-Q10-Q12-nap-PG1501 |
|
| E13 | Pre-grant limitation requested |
Free format text: ST27 STATUS EVENT CODE: A-2-3-E10-E13-LIM-X000 (AS PROVIDED BY THE NATIONAL OFFICE) |
|
| E13-X000 | Pre-grant limitation requested |
St.27 status event code: A-2-3-E10-E13-lim-X000 |
|
| P11 | Amendment of application requested |
Free format text: ST27 STATUS EVENT CODE: A-2-2-P10-P11-NAP-X000 (AS PROVIDED BY THE NATIONAL OFFICE) |
|
| P11-X000 | Amendment of application requested |
St.27 status event code: A-2-2-P10-P11-nap-X000 |