KR20240136952A - Bcma에 결합하는 항체 및 이의 용도 - Google Patents

Bcma에 결합하는 항체 및 이의 용도 Download PDF

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Publication number
KR20240136952A
KR20240136952A KR1020247022135A KR20247022135A KR20240136952A KR 20240136952 A KR20240136952 A KR 20240136952A KR 1020247022135 A KR1020247022135 A KR 1020247022135A KR 20247022135 A KR20247022135 A KR 20247022135A KR 20240136952 A KR20240136952 A KR 20240136952A
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Prior art keywords
seq
set forth
antibody
bcma
amino acid
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Korean (ko)
Inventor
후아펭 웨이
단 수
다이아나 비니아 다로브스키
비앙카 프린츠
나드타카른 볼랜드
제임스 지오게간
Original Assignee
이노벤트 바이오로직스 (쑤저우) 컴퍼니, 리미티드
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Priority claimed from CN202111487287.1A external-priority patent/CN116284385A/zh
Application filed by 이노벤트 바이오로직스 (쑤저우) 컴퍼니, 리미티드 filed Critical 이노벤트 바이오로직스 (쑤저우) 컴퍼니, 리미티드
Publication of KR20240136952A publication Critical patent/KR20240136952A/ko
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KR1020247022135A 2021-12-07 2022-12-07 Bcma에 결합하는 항체 및 이의 용도 Pending KR20240136952A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN202111487287.1 2021-12-07
CN202111487287.1A CN116284385A (zh) 2021-12-07 2021-12-07 靶向bcma的p329g抗体及其与嵌合抗原受体细胞的组合和应用
PCT/CN2022/137266 WO2023104100A1 (zh) 2021-12-07 2022-12-07 结合bcma的抗体及其用途

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US (1) US20250034268A1 (cg-RX-API-DMAC10.html)
EP (1) EP4446341A4 (cg-RX-API-DMAC10.html)
JP (1) JP2025501461A (cg-RX-API-DMAC10.html)
KR (1) KR20240136952A (cg-RX-API-DMAC10.html)
CN (1) CN118339185A (cg-RX-API-DMAC10.html)
AU (1) AU2022405415A1 (cg-RX-API-DMAC10.html)
CA (1) CA3241912A1 (cg-RX-API-DMAC10.html)
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WO2026158539A1 (zh) * 2025-01-24 2026-07-30 信达生物制药(苏州)有限公司 靶向cd19,bcma和cd3的三特异性抗体及其用途

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US5336603A (en) 1987-10-02 1994-08-09 Genentech, Inc. CD4 adheson variants
KR900005995A (ko) 1988-10-31 1990-05-07 우메모또 요시마사 변형 인터류킨-2 및 그의 제조방법
US5622929A (en) 1992-01-23 1997-04-22 Bristol-Myers Squibb Company Thioether conjugates
UA112434C2 (uk) 2011-05-27 2016-09-12 Ґлаксо Ґруп Лімітед Антигензв'язувальний білок, який специфічно зв'язується з всма
CN105384825B (zh) * 2015-08-11 2018-06-01 南京传奇生物科技有限公司 一种基于单域抗体的双特异性嵌合抗原受体及其应用
EP3572427B1 (en) * 2017-01-23 2025-06-25 CRAGE medical Co., Limited Bcma-targeting antibody and use thereof
AU2019214183B2 (en) * 2018-02-01 2022-04-07 Innovent Biologics (Suzhou) Co., Ltd. Fully human anti-B cell maturation antigen (BCMA) single chain variable fragment, and application thereof
WO2020004937A1 (ko) * 2018-06-26 2020-01-02 주식회사 티에스디라이프사이언스 항-bcma 항체-약물 접합체 및 그 용도
CN109265550B (zh) * 2018-09-25 2020-09-15 华东师范大学 Bcma抗体、嵌合抗原受体和药物
JP2023501871A (ja) * 2019-09-20 2023-01-20 上海吉倍生物技術有限公司 Bcma標的化抗体及びキメラ抗原受容体
WO2021146147A1 (en) * 2020-01-13 2021-07-22 Nkarta, Inc. Bcma-directed cellular immunotherapy compositions and methods
CN119604525A (zh) * 2022-07-22 2025-03-11 信达生物制药(苏州)有限公司 促进多特异性抗体的重链和轻链同源配对的突变体

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