JP2025501461A - Ｂｃｍａに結合する抗体およびその使用 - Google Patents

Ｂｃｍａに結合する抗体およびその使用 Download PDF

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JP2025501461A
JP2025501461A JP2024533998A JP2024533998A JP2025501461A JP 2025501461 A JP2025501461 A JP 2025501461A JP 2024533998 A JP2024533998 A JP 2024533998A JP 2024533998 A JP2024533998 A JP 2024533998A JP 2025501461 A JP2025501461 A JP 2025501461A
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seq
amino acid
antibody
bcma
variable region
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JP2025501461A5 (cg-RX-API-DMAC10.html
Inventor
ホアフォン ウェイ
タン シュイ
ビニア ダロウスキ ダイアナ
プリンツ ビアンカ
ボーランド ナドタカーン
ジョーゲガン ジェイムズ
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イノベント バイオロジクス（スーチョウ）カンパニー，リミティド
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Priority claimed from CN202111487287.1A external-priority patent/CN116284385A/zh
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Publication of JP2025501461A publication Critical patent/JP2025501461A/ja
Publication of JP2025501461A5 publication Critical patent/JP2025501461A5/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • C—CHEMISTRY; METALLURGY
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    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • C12N15/09—Recombinant DNA-technology
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    • C12N15/62—DNA sequences coding for fusion proteins
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    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
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    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/5758—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumours, cancers or neoplasias, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides or metabolites
    • G01N33/5759—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumours, cancers or neoplasias, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides or metabolites involving compounds localised on the membrane of tumour or cancer cells
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    • C07K2319/00—Fusion polypeptide
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JP2024533998A 2021-12-07 2022-12-07 Ｂｃｍａに結合する抗体およびその使用 Pending JP2025501461A (ja)

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Application Number Priority Date Filing Date Title
CN202111487287.1 2021-12-07
CN202111487287.1A CN116284385A (zh) 2021-12-07 2021-12-07 靶向bcma的p329g抗体及其与嵌合抗原受体细胞的组合和应用
PCT/CN2022/137266 WO2023104100A1 (zh) 2021-12-07 2022-12-07 结合bcma的抗体及其用途

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JP2025501461A5 JP2025501461A5 (cg-RX-API-DMAC10.html) 2025-12-15

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US5336603A (en) 1987-10-02 1994-08-09 Genentech, Inc. CD4 adheson variants
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