CN118339185A - 结合bcma的抗体及其用途 - Google Patents

结合bcma的抗体及其用途 Download PDF

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Publication number
CN118339185A
CN118339185A CN202280081161.0A CN202280081161A CN118339185A CN 118339185 A CN118339185 A CN 118339185A CN 202280081161 A CN202280081161 A CN 202280081161A CN 118339185 A CN118339185 A CN 118339185A
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China
Prior art keywords
seq
amino acid
antibody
bcma
variable region
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Pending
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CN202280081161.0A
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Chinese (zh)
Inventor
危华锋
许丹
戴安娜·比尼亚·达洛夫斯基
比安卡·普里恩斯
奈德赛卡恩·博兰
詹姆斯·盖根
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Innovent Biologics (Suzhou) Co Ltd
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Innovent Biologics (Suzhou) Co Ltd
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Priority claimed from CN202111487287.1A external-priority patent/CN116284385A/zh
Application filed by Innovent Biologics (Suzhou) Co Ltd filed Critical Innovent Biologics (Suzhou) Co Ltd
Publication of CN118339185A publication Critical patent/CN118339185A/zh
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CN202280081161.0A 2021-12-07 2022-12-07 结合bcma的抗体及其用途 Pending CN118339185A (zh)

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CN2021114872871 2021-12-07
CN202111487287.1A CN116284385A (zh) 2021-12-07 2021-12-07 靶向bcma的p329g抗体及其与嵌合抗原受体细胞的组合和应用
PCT/CN2022/137266 WO2023104100A1 (zh) 2021-12-07 2022-12-07 结合bcma的抗体及其用途

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WO2026158539A1 (zh) * 2025-01-24 2026-07-30 信达生物制药(苏州)有限公司 靶向cd19，bcma和cd3的三特异性抗体及其用途

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5336603A (en) 1987-10-02 1994-08-09 Genentech, Inc. CD4 adheson variants
KR900005995A (ko) 1988-10-31 1990-05-07 우메모또 요시마사 변형 인터류킨-2 및 그의 제조방법
US5622929A (en) 1992-01-23 1997-04-22 Bristol-Myers Squibb Company Thioether conjugates
UA112434C2 (uk) 2011-05-27 2016-09-12 Ґлаксо Ґруп Лімітед Антигензв'язувальний білок, який специфічно зв'язується з всма
CN105384825B (zh) * 2015-08-11 2018-06-01 南京传奇生物科技有限公司 一种基于单域抗体的双特异性嵌合抗原受体及其应用
EP3572427B1 (en) * 2017-01-23 2025-06-25 CRAGE medical Co., Limited Bcma-targeting antibody and use thereof
AU2019214183B2 (en) * 2018-02-01 2022-04-07 Innovent Biologics (Suzhou) Co., Ltd. Fully human anti-B cell maturation antigen (BCMA) single chain variable fragment, and application thereof
WO2020004937A1 (ko) * 2018-06-26 2020-01-02 주식회사 티에스디라이프사이언스 항-bcma 항체-약물 접합체 및 그 용도
CN109265550B (zh) * 2018-09-25 2020-09-15 华东师范大学 Bcma抗体、嵌合抗原受体和药物
JP2023501871A (ja) * 2019-09-20 2023-01-20 上海吉倍生物技術有限公司 Ｂｃｍａ標的化抗体及びキメラ抗原受容体
WO2021146147A1 (en) * 2020-01-13 2021-07-22 Nkarta, Inc. Bcma-directed cellular immunotherapy compositions and methods
CN119604525A (zh) * 2022-07-22 2025-03-11 信达生物制药(苏州)有限公司 促进多特异性抗体的重链和轻链同源配对的突变体

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