KR20240134248A - 항-인자 XI/XIa 항체를 사용한 치료 방법 - Google Patents

항-인자 XI/XIa 항체를 사용한 치료 방법 Download PDF

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Publication number
KR20240134248A
KR20240134248A KR1020247029148A KR20247029148A KR20240134248A KR 20240134248 A KR20240134248 A KR 20240134248A KR 1020247029148 A KR1020247029148 A KR 1020247029148A KR 20247029148 A KR20247029148 A KR 20247029148A KR 20240134248 A KR20240134248 A KR 20240134248A
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KR
South Korea
Prior art keywords
antibody
fxi
fxia
seq
amino acid
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Pending
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KR1020247029148A
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English (en)
Korean (ko)
Inventor
캐롤라 프리드먼
위아서 크더
마틴 레프코위즈
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노파르티스 아게
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Publication of KR20240134248A publication Critical patent/KR20240134248A/ko
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/36—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against blood coagulation factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Hematology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Diabetes (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
KR1020247029148A 2016-12-23 2017-12-22 항-인자 XI/XIa 항체를 사용한 치료 방법 Pending KR20240134248A (ko)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201662438654P 2016-12-23 2016-12-23
US62/438,654 2016-12-23
US201762589851P 2017-11-22 2017-11-22
US62/589,851 2017-11-22
KR1020197021024A KR102702288B1 (ko) 2016-12-23 2017-12-22 항-인자 XI/XIa 항체를 사용한 치료 방법
PCT/IB2017/058345 WO2018116267A2 (en) 2016-12-23 2017-12-22 Methods of treatment with anti-factor xi/xia antibodies

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
KR1020197021024A Division KR102702288B1 (ko) 2016-12-23 2017-12-22 항-인자 XI/XIa 항체를 사용한 치료 방법

Publications (1)

Publication Number Publication Date
KR20240134248A true KR20240134248A (ko) 2024-09-06

Family

ID=61022382

Family Applications (2)

Application Number Title Priority Date Filing Date
KR1020247029148A Pending KR20240134248A (ko) 2016-12-23 2017-12-22 항-인자 XI/XIa 항체를 사용한 치료 방법
KR1020197021024A Active KR102702288B1 (ko) 2016-12-23 2017-12-22 항-인자 XI/XIa 항체를 사용한 치료 방법

Family Applications After (1)

Application Number Title Priority Date Filing Date
KR1020197021024A Active KR102702288B1 (ko) 2016-12-23 2017-12-22 항-인자 XI/XIa 항체를 사용한 치료 방법

Country Status (9)

Country Link
US (3) US20200231701A1 (enExample)
EP (1) EP3558370A2 (enExample)
JP (3) JP7110199B2 (enExample)
KR (2) KR20240134248A (enExample)
CN (2) CN110325211A (enExample)
AU (2) AU2017383537B2 (enExample)
CA (1) CA3048157A1 (enExample)
IL (2) IL267519B2 (enExample)
WO (1) WO2018116267A2 (enExample)

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CN106715473B (zh) 2014-10-01 2021-11-23 免疫医疗有限公司 替格瑞洛的抗体及其使用方法
JOP20200312A1 (ar) 2015-06-26 2017-06-16 Novartis Ag الأجسام المضادة للعامل xi وطرق الاستخدام
TW201802121A (zh) 2016-05-25 2018-01-16 諾華公司 抗因子XI/XIa抗體之逆轉結合劑及其用途
CN110325211A (zh) * 2016-12-23 2019-10-11 诺华股份有限公司 采用抗因子XI/XIa抗体治疗的方法
IL308980A (en) 2016-12-23 2024-01-01 Novartis Ag Antibodies against factor XI and methods of their use
US20210347915A1 (en) 2018-09-20 2021-11-11 Phasebio Pharmaceuticals, Inc. Methods of reversing ticagrelor activity
KR20210151774A (ko) * 2019-04-16 2021-12-14 쓰촨 케룬-바이오테크 바이오파마수티컬 컴퍼니 리미티드 항-FXI/FXIa 항체 및 그 용도
CN110423278B (zh) * 2019-08-08 2020-07-17 上海博槿生物科技有限公司 一种抗凝血因子XI活化形式因子XIa的抗体及其制备方法和应用
CA3161118A1 (en) * 2019-12-20 2021-06-24 Anthos Therapeutics, Inc. Pharmaceutical formulations and dosage regimens for factor xi/xia antibodies
TW202405022A (zh) * 2022-06-24 2024-02-01 美商安瑟斯治療公司 與抗因子ｘｉ／因子ｘｉａ抗體之組合療法

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CN110325211A (zh) * 2016-12-23 2019-10-11 诺华股份有限公司 采用抗因子XI/XIa抗体治疗的方法

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Publication number Publication date
IL267519A (en) 2019-08-29
AU2017383537A1 (en) 2019-06-27
US20200231701A1 (en) 2020-07-23
US20250197522A1 (en) 2025-06-19
KR20190099256A (ko) 2019-08-26
US20230002507A1 (en) 2023-01-05
EP3558370A2 (en) 2019-10-30
JP2024116221A (ja) 2024-08-27
JP7500662B2 (ja) 2024-06-17
JP7110199B2 (ja) 2022-08-01
CN118320078A (zh) 2024-07-12
IL316673A (en) 2024-12-01
KR102702288B1 (ko) 2024-09-05
WO2018116267A3 (en) 2018-08-02
AU2017383537B2 (en) 2024-10-03
JP2020504110A (ja) 2020-02-06
IL267519B2 (en) 2025-04-01
CA3048157A1 (en) 2018-06-28
WO2018116267A2 (en) 2018-06-28
CN110325211A (zh) 2019-10-11
JP2022141831A (ja) 2022-09-29
IL267519B1 (en) 2024-12-01
AU2024287181A1 (en) 2025-03-06

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