KR20240130138A - Il-1 베타 결합 단백질의 재료 및 방법 - Google Patents

Il-1 베타 결합 단백질의 재료 및 방법 Download PDF

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Publication number
KR20240130138A
KR20240130138A KR1020247026383A KR20247026383A KR20240130138A KR 20240130138 A KR20240130138 A KR 20240130138A KR 1020247026383 A KR1020247026383 A KR 1020247026383A KR 20247026383 A KR20247026383 A KR 20247026383A KR 20240130138 A KR20240130138 A KR 20240130138A
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KR
South Korea
Prior art keywords
seq
amino acid
acid sequence
antibody
cdr1
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Pending
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KR1020247026383A
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English (en)
Korean (ko)
Inventor
가브리엘 파스쿠알
사지트 힌디
슈레쉬 쿠마르 스와미나탄
매튜 제이. 에드워즈
크리스토퍼 스콧 스티븐슨
Original Assignee
존슨 앤드 존슨 엔터프라이즈 이노베이션 인코포레이티드
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Publication of KR20240130138A publication Critical patent/KR20240130138A/ko
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • C07K16/245—IL-1
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
KR1020247026383A 2022-01-07 2023-01-06 Il-1 베타 결합 단백질의 재료 및 방법 Pending KR20240130138A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202263297436P 2022-01-07 2022-01-07
US63/297,436 2022-01-07
PCT/IB2023/050106 WO2023131901A1 (en) 2022-01-07 2023-01-06 Materials and methods of il-1beta binding proteins

Publications (1)

Publication Number Publication Date
KR20240130138A true KR20240130138A (ko) 2024-08-28

Family

ID=84981504

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020247026383A Pending KR20240130138A (ko) 2022-01-07 2023-01-06 Il-1 베타 결합 단백질의 재료 및 방법

Country Status (18)

Country Link
US (1) US20230227545A1 (https=)
EP (1) EP4460517A1 (https=)
JP (1) JP2025504383A (https=)
KR (1) KR20240130138A (https=)
CN (1) CN118974083A (https=)
AR (1) AR128222A1 (https=)
AU (1) AU2023206045A1 (https=)
CA (1) CA3247125A1 (https=)
CL (1) CL2024002031A1 (https=)
CO (1) CO2024009735A2 (https=)
DO (1) DOP2024000129A (https=)
IL (1) IL314129A (https=)
JO (1) JOP20240153A1 (https=)
MX (1) MX2024008553A (https=)
PE (1) PE20242347A1 (https=)
TW (1) TW202337904A (https=)
UY (1) UY40097A (https=)
WO (1) WO2023131901A1 (https=)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2025186317A1 (en) * 2024-03-06 2025-09-12 Elanco Us Inc. Veterinary compositions of modified virus-like particles of cmv and canine il-1beta mutein antigens

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