KR20240115849A - 라벡시모드 화합물 - Google Patents

라벡시모드 화합물 Download PDF

Info

Publication number
KR20240115849A
KR20240115849A KR1020247020481A KR20247020481A KR20240115849A KR 20240115849 A KR20240115849 A KR 20240115849A KR 1020247020481 A KR1020247020481 A KR 1020247020481A KR 20247020481 A KR20247020481 A KR 20247020481A KR 20240115849 A KR20240115849 A KR 20240115849A
Authority
KR
South Korea
Prior art keywords
compound
salt
rheumatoid arthritis
rabeximod
salts
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
KR1020247020481A
Other languages
English (en)
Korean (ko)
Inventor
브라운 윌리엄 달비
핀스테렌 로렌스 아드리아누스 헨드리쿠스 반
리엔크 엘리버트 스틴담
조나단 크니베
말린 잉그리드 베르톨트
Original Assignee
사익손 아베
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 사익손 아베 filed Critical 사익손 아베
Publication of KR20240115849A publication Critical patent/KR20240115849A/ko
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01—Sulfonic acids
    • C07C309/02—Sulfonic acids having sulfo groups bound to acyclic carbon atoms
    • C07C309/03—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C309/04—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton containing only one sulfo group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C55/00—Saturated compounds having more than one carboxyl group bound to acyclic carbon atoms
    • C07C55/02—Dicarboxylic acids
    • C07C55/08—Malonic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Rheumatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Fire-Extinguishing Compositions (AREA)
KR1020247020481A 2021-12-09 2022-12-08 라벡시모드 화합물 Pending KR20240115849A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP21213418 2021-12-09
EP21213418.3 2021-12-09
PCT/EP2022/085060 WO2023104998A1 (en) 2021-12-09 2022-12-08 Rabeximod compounds

Publications (1)

Publication Number Publication Date
KR20240115849A true KR20240115849A (ko) 2024-07-26

Family

ID=78827545

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020247020481A Pending KR20240115849A (ko) 2021-12-09 2022-12-08 라벡시모드 화합물

Country Status (8)

Country Link
US (1) US11643415B1 (https=)
EP (1) EP4444720A1 (https=)
JP (1) JP2024546098A (https=)
KR (1) KR20240115849A (https=)
CN (1) CN118647618A (https=)
AU (1) AU2022407139A1 (https=)
CA (1) CA3239544A1 (https=)
WO (1) WO2023104998A1 (https=)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20230022880A (ko) * 2020-06-10 2023-02-16 사익손 아베 라벡시모드의 결정성 형태를 포함하는 경구 제형

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE527639C2 (sv) 2004-06-17 2006-05-02 Oxypharma Ab Alkylsubstituerade indolokinoxaliner
EA201500942A1 (ru) * 2013-03-15 2016-03-31 Виронова Херпес Аб ПРОТИВОВИРУСНЫЙ ИНДОЛО[2,3-b]ХИНОКСАЛИН
KR20230022880A (ko) 2020-06-10 2023-02-16 사익손 아베 라벡시모드의 결정성 형태를 포함하는 경구 제형

Also Published As

Publication number Publication date
CA3239544A1 (en) 2023-06-15
AU2022407139A1 (en) 2024-05-23
EP4444720A1 (en) 2024-10-16
CN118647618A (zh) 2024-09-13
WO2023104998A1 (en) 2023-06-15
US11643415B1 (en) 2023-05-09
JP2024546098A (ja) 2024-12-17

Similar Documents

Publication Publication Date Title
US12419877B2 (en) Solid forms of {[5-(3-chlorophenyl)-3-hydroxypyridine-2-carbonyl]amino}acetic acid, compositions, and uses thereof
US8552038B2 (en) Crystalline forms of thiazolidinedione compound and its manufacturing method
JP2011506374A (ja) テノホビルジソプロキシルの固形物
US9856270B2 (en) Dolutegravir salts
KR20240115849A (ko) 라벡시모드 화합물
US11267791B2 (en) Highly stable crystalline Eltrombopag monoethanolamine salt form D1
US11306062B2 (en) Forms of fedratinib dihydrochloride
AU2004232495B2 (en) 4-(4-trans-hydroxycyclohexyl)amino-2-phenyl-7h-pyrrolo [2, 3d]pyrimidine hydrogen mesylate and its polymorphic forms
EP4631937A1 (en) Crystalline form or amorphous form of oxoisoindole-5-formamide compound or salt and solvate thereof
US20230265043A1 (en) Crystalline form of phentermine hydrochloride and process for obtaining same
JP2018515477A (ja) 免疫調節薬の新規な結晶形
CN107663198A (zh) 奥美沙坦酯及其制备方法和用途
TW202506661A (zh) 一種酪氨酸激酶抑制劑的可藥用鹽、結晶形式及其製備方法
CN121270414A (zh) 一种美洛加巴林-4-羟基苯甲酸晶型
AU2021231396A1 (en) Salts and polymorphic forms of 6-chloro-7-(4-(4-chlorobenzyl)piperazin-1-yl)-2-(1,3-dimethyl-1H-pyrazol-4-yl)-3H-imidazo[4,5-b]pyridine
US20100216831A1 (en) Desloratadine crystalline forms mixtures having a low level of residual solvents
HK40036995A (en) Crystals of glycyrrhizic acid derivatives, crystalline compositions, pharmaceutical compositions and uses thereof
WO2018162394A1 (en) Vinpocetine hydrochloride crystalline forms
WO2019053491A1 (en) CRYSTALLINE BENIDIPINE HCL SOLID FORMS AND PROCESSES FOR PREPARING THE SAME

Legal Events

Date Code Title Description
PA0105 International application

St.27 status event code: A-0-1-A10-A15-nap-PA0105

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

PG1501 Laying open of application

St.27 status event code: A-1-1-Q10-Q12-nap-PG1501

PN2301 Change of applicant

St.27 status event code: A-3-3-R10-R11-asn-PN2301

R11 Change to the name of applicant or owner or transfer of ownership requested

Free format text: ST27 STATUS EVENT CODE: A-3-3-R10-R11-ASN-PN2301 (AS PROVIDED BY THE NATIONAL OFFICE)