AU2022407139A1 - Rabeximod compounds - Google Patents
Rabeximod compounds Download PDFInfo
- Publication number
- AU2022407139A1 AU2022407139A1 AU2022407139A AU2022407139A AU2022407139A1 AU 2022407139 A1 AU2022407139 A1 AU 2022407139A1 AU 2022407139 A AU2022407139 A AU 2022407139A AU 2022407139 A AU2022407139 A AU 2022407139A AU 2022407139 A1 AU2022407139 A1 AU 2022407139A1
- Authority
- AU
- Australia
- Prior art keywords
- compound
- salt
- rabeximod
- rheumatoid arthritis
- crystalline form
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- PDNNUMNEXITLCZ-UHFFFAOYSA-N 2-(9-chloro-2,3-dimethylindolo[3,2-b]quinoxalin-6-yl)-n-[2-(dimethylamino)ethyl]acetamide Chemical class CC1=C(C)C=C2N=C3N(CC(=O)NCCN(C)C)C4=CC=C(Cl)C=C4C3=NC2=C1 PDNNUMNEXITLCZ-UHFFFAOYSA-N 0.000 title claims abstract description 73
- 229950006043 rabeximod Drugs 0.000 claims abstract description 54
- AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical class CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 claims abstract description 24
- OFOBLEOULBTSOW-UHFFFAOYSA-N Malonic acid Chemical class OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 claims abstract description 23
- 150000001875 compounds Chemical class 0.000 claims description 76
- 150000003839 salts Chemical class 0.000 claims description 55
- 238000000634 powder X-ray diffraction Methods 0.000 claims description 41
- 239000007787 solid Substances 0.000 claims description 36
- 238000000034 method Methods 0.000 claims description 29
- 206010039073 rheumatoid arthritis Diseases 0.000 claims description 28
- 239000012458 free base Substances 0.000 claims description 24
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- GXHMMDRXHUIUMN-UHFFFAOYSA-N methanesulfonic acid Chemical compound CS(O)(=O)=O.CS(O)(=O)=O GXHMMDRXHUIUMN-UHFFFAOYSA-N 0.000 claims description 2
- 238000001556 precipitation Methods 0.000 claims description 2
- XMIIGOLPHOKFCH-UHFFFAOYSA-N 3-phenylpropionic acid Chemical class OC(=O)CCC1=CC=CC=C1 XMIIGOLPHOKFCH-UHFFFAOYSA-N 0.000 claims 4
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- IAZDPXIOMUYVGZ-WFGJKAKNSA-N Dimethyl sulfoxide Chemical compound [2H]C([2H])([2H])S(=O)C([2H])([2H])[2H] IAZDPXIOMUYVGZ-WFGJKAKNSA-N 0.000 description 4
- 241000699666 Mus <mouse, genus> Species 0.000 description 4
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- 229910052738 indium Inorganic materials 0.000 description 2
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- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
- C07C309/01—Sulfonic acids
- C07C309/02—Sulfonic acids having sulfo groups bound to acyclic carbon atoms
- C07C309/03—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
- C07C309/04—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton containing only one sulfo group
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C55/00—Saturated compounds having more than one carboxyl group bound to acyclic carbon atoms
- C07C55/02—Dicarboxylic acids
- C07C55/08—Malonic acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Rheumatology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Physical Education & Sports Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Fire-Extinguishing Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP21213418 | 2021-12-09 | ||
| EP21213418.3 | 2021-12-09 | ||
| PCT/EP2022/085060 WO2023104998A1 (en) | 2021-12-09 | 2022-12-08 | Rabeximod compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AU2022407139A1 true AU2022407139A1 (en) | 2024-05-23 |
Family
ID=78827545
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2022407139A Pending AU2022407139A1 (en) | 2021-12-09 | 2022-12-08 | Rabeximod compounds |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US11643415B1 (https=) |
| EP (1) | EP4444720A1 (https=) |
| JP (1) | JP2024546098A (https=) |
| KR (1) | KR20240115849A (https=) |
| CN (1) | CN118647618A (https=) |
| AU (1) | AU2022407139A1 (https=) |
| CA (1) | CA3239544A1 (https=) |
| WO (1) | WO2023104998A1 (https=) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20230022880A (ko) * | 2020-06-10 | 2023-02-16 | 사익손 아베 | 라벡시모드의 결정성 형태를 포함하는 경구 제형 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE527639C2 (sv) | 2004-06-17 | 2006-05-02 | Oxypharma Ab | Alkylsubstituerade indolokinoxaliner |
| EA201500942A1 (ru) * | 2013-03-15 | 2016-03-31 | Виронова Херпес Аб | ПРОТИВОВИРУСНЫЙ ИНДОЛО[2,3-b]ХИНОКСАЛИН |
| KR20230022880A (ko) | 2020-06-10 | 2023-02-16 | 사익손 아베 | 라벡시모드의 결정성 형태를 포함하는 경구 제형 |
-
2022
- 2022-08-19 US US17/891,462 patent/US11643415B1/en active Active
- 2022-12-08 AU AU2022407139A patent/AU2022407139A1/en active Pending
- 2022-12-08 CN CN202280081094.2A patent/CN118647618A/zh active Pending
- 2022-12-08 WO PCT/EP2022/085060 patent/WO2023104998A1/en not_active Ceased
- 2022-12-08 JP JP2024534019A patent/JP2024546098A/ja active Pending
- 2022-12-08 KR KR1020247020481A patent/KR20240115849A/ko active Pending
- 2022-12-08 CA CA3239544A patent/CA3239544A1/en active Pending
- 2022-12-08 EP EP22834585.6A patent/EP4444720A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| CA3239544A1 (en) | 2023-06-15 |
| EP4444720A1 (en) | 2024-10-16 |
| CN118647618A (zh) | 2024-09-13 |
| KR20240115849A (ko) | 2024-07-26 |
| WO2023104998A1 (en) | 2023-06-15 |
| US11643415B1 (en) | 2023-05-09 |
| JP2024546098A (ja) | 2024-12-17 |
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