KR20240110576A - Crbn e3 리가제 리간드 화합물, 리간드 화합물에 기초하여 개발된 단백질 분해제 및 이들의 응용 - Google Patents

Crbn e3 리가제 리간드 화합물, 리간드 화합물에 기초하여 개발된 단백질 분해제 및 이들의 응용 Download PDF

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KR20240110576A
KR20240110576A KR1020247016562A KR20247016562A KR20240110576A KR 20240110576 A KR20240110576 A KR 20240110576A KR 1020247016562 A KR1020247016562 A KR 1020247016562A KR 20247016562 A KR20247016562 A KR 20247016562A KR 20240110576 A KR20240110576 A KR 20240110576A
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dioxopiperidin
dione
methyl
amino
diazabicyclo
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Korean (ko)
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샤오바오 양
런홍 선
바오인 자오
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글루탁스 테라퓨틱스 (상하이) 씨오., 엘티디.
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    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
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KR1020247016562A 2021-10-22 2022-10-20 Crbn e3 리가제 리간드 화합물, 리간드 화합물에 기초하여 개발된 단백질 분해제 및 이들의 응용 Pending KR20240110576A (ko)

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CN202111231963.9 2021-10-22
CN202111231963 2021-10-22
PCT/CN2022/126516 WO2023066350A1 (zh) 2021-10-22 2022-10-20 Crbn e3连接酶配体化合物、基于该配体化合物开发的蛋白降解剂及它们的应用

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US (1) US20250243210A1 (https=)
EP (1) EP4421071A4 (https=)
JP (1) JP2024539269A (https=)
KR (1) KR20240110576A (https=)
CN (1) CN116003418A (https=)
AU (1) AU2022370021B2 (https=)
CA (1) CA3235512A1 (https=)
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CN120548310A (zh) * 2023-12-26 2025-08-26 标新生物医药科技(上海)有限公司 具有双氮杂环取代的异吲哚啉酮骨架的化合物及其应用
CN120787222A (zh) * 2024-02-04 2025-10-14 标新生物医药科技(上海)有限公司 基于取代的异吲哚啉酮新颖骨架化合物、含有其的双功能蛋白降解剂及它们的应用
CN120787219A (zh) * 2024-02-04 2025-10-14 标新生物医药科技(上海)有限公司 具有取代的戊二酰亚胺基异吲哚啉酮新颖骨架的化合物及其应用
WO2025212165A1 (en) * 2024-04-05 2025-10-09 Board Of Regents Of The University Of Nebraska Targeted heterobifunctional small molecule proteolysis targeting chimeras
WO2026061104A1 (zh) * 2024-07-05 2026-03-26 甘李药业股份有限公司 用于雄激素受体靶向降解的化合物和方法
CN118955474A (zh) * 2024-07-29 2024-11-15 浙江爱索拓标记医药科技有限公司 一种放射性同位素碳-14标记的巴德卡鲁胺及其制备方法和应用
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