KR20240090927A - 항암 조합 요법 - Google Patents
항암 조합 요법 Download PDFInfo
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- KR20240090927A KR20240090927A KR1020247017327A KR20247017327A KR20240090927A KR 20240090927 A KR20240090927 A KR 20240090927A KR 1020247017327 A KR1020247017327 A KR 1020247017327A KR 20247017327 A KR20247017327 A KR 20247017327A KR 20240090927 A KR20240090927 A KR 20240090927A
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Classifications
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- A61K31/5365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines ortho- or peri-condensed with heterocyclic ring systems
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- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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- C—CHEMISTRY; METALLURGY
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- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
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- Veterinary Medicine (AREA)
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- Mycology (AREA)
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- Oncology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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| EP17197930 | 2017-10-24 | ||
| PCT/EP2018/058562 WO2018185135A1 (en) | 2017-04-05 | 2018-04-04 | Anticancer combination therapy |
| KR1020197032689A KR20190132687A (ko) | 2017-04-05 | 2018-04-04 | 항암 조합 요법 |
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| EP (2) | EP4368200A3 (enExample) |
| JP (2) | JP2020516604A (enExample) |
| KR (2) | KR20240090927A (enExample) |
| CN (2) | CN110505884B (enExample) |
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| BR (1) | BR112019021032A2 (enExample) |
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| JP7014706B2 (ja) | 2015-07-13 | 2022-02-01 | サイトメックス セラピューティクス インコーポレイテッド | 抗ｐｄ－１抗体、活性化可能抗ｐｄ－１抗体、およびその使用方法 |
| SI3356411T1 (sl) | 2015-10-02 | 2021-09-30 | F. Hoffmann-La Roche Ag | Bispecifična protitelesa, specifična za PD1 in TIM3 |
| WO2018071500A1 (en) | 2016-10-11 | 2018-04-19 | Agenus Inc. | Anti-lag-3 antibodies and methods of use thereof |
| MX2019011770A (es) | 2017-04-03 | 2020-01-09 | Hoffmann La Roche | Inmunoconjugados de un anticuerpo anti-pd-1 con un mutante il-2 o con il-15. |
| DK3606955T3 (da) | 2017-04-05 | 2025-01-13 | Hoffmann La Roche | Bispecifikke antistoffer, der specifikt binder sig til PD1 og LAG3 |
| BR112020018755A2 (pt) * | 2018-03-20 | 2021-01-05 | Novartis Ag | Combinações farmacêuticas |
| WO2020023502A1 (en) | 2018-07-23 | 2020-01-30 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles and uses thereof |
| WO2020030016A1 (en) * | 2018-08-08 | 2020-02-13 | Ascentage Pharma (Suzhou) Co., Ltd. | Combination of immunotherapies with mdm2 inhibitors |
| EP4603098A3 (en) * | 2018-11-01 | 2025-09-03 | Alpha Tau Medical Ltd. | Intratumoral alpha-emitter radiation and activation of cytoplasmatic sensors for intracellular pathogen |
| US20220040166A1 (en) * | 2018-12-11 | 2022-02-10 | Kartos Therapeutics | Methods and Compositions of Treating an Ophthalmic Condition |
| TW202327584A (zh) | 2021-08-09 | 2023-07-16 | 德商百靈佳殷格翰國際股份有限公司 | 用於癌症療法之新穎口服醫藥組合物 |
| CN115089585A (zh) * | 2022-08-05 | 2022-09-23 | 中国科学院大学宁波华美医院 | Mdm2抑制剂rg7112联合依托泊苷在治疗肺癌中的应用 |
| WO2024133637A1 (en) * | 2022-12-22 | 2024-06-27 | Boehringer Ingelheim International Gmbh | Crystalline form of an mdm2-p53 inhibitor and pharmaceutical compositions |
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| DK2161336T4 (en) | 2005-05-09 | 2017-04-24 | Ono Pharmaceutical Co | Human monoclonal antibodies for programmed death 1 (PD-1) and methods for treating cancer using anti-PD-1 antibodies alone or in combination with other immunotherapies |
| WO2008005268A1 (en) | 2006-06-30 | 2008-01-10 | Schering Corporation | Substituted piperidines that increase p53 activity and the uses thereof |
| AU2008234954B9 (en) | 2007-03-29 | 2012-02-02 | Novartis Ag | 3-imidazolyl-indoles for the treatment of proliferative diseases |
| NZ582150A (en) | 2007-06-18 | 2012-08-31 | Msd Oss Bv | Antibodies to human programmed death receptor pd-1 |
| MX2010008786A (es) | 2008-02-11 | 2010-12-01 | Curetech Ltd | Anticuerpos monoclonales para tratamiento de tumores. |
| WO2009114335A2 (en) | 2008-03-12 | 2009-09-17 | Merck & Co., Inc. | Pd-1 binding proteins |
| AR073578A1 (es) | 2008-09-15 | 2010-11-17 | Priaxon Ag | Pirrolidin-2-onas |
| WO2010089411A2 (en) * | 2009-02-09 | 2010-08-12 | Universite De La Mediterranee | Pd-1 antibodies and pd-l1 antibodies and uses thereof |
| US8440693B2 (en) | 2009-12-22 | 2013-05-14 | Novartis Ag | Substituted isoquinolinones and quinazolinones |
| US8815926B2 (en) | 2012-01-26 | 2014-08-26 | Novartis Ag | Substituted pyrrolo[3,4-D]imidazoles for the treatment of MDM2/4 mediated diseases |
| PL3508502T3 (pl) | 2013-09-20 | 2023-07-17 | Bristol-Myers Squibb Company | Kombinacja przeciwciał anty-lag-3 i przeciwciał anty-pd-1 w leczeniu raka |
| JOP20200094A1 (ar) | 2014-01-24 | 2017-06-16 | Dana Farber Cancer Inst Inc | جزيئات جسم مضاد لـ pd-1 واستخداماتها |
| LT3116909T (lt) | 2014-03-14 | 2020-02-10 | Novartis Ag | Antikūno molekulės prieš lag-3 ir jų panaudojimas |
| US10138251B2 (en) | 2014-04-11 | 2018-11-27 | Boehringer Ingelheim International Gmbh | Spiro[3H-indole-3,2′-pyrrolidin]-2(1H)-one compounds and derivatives as MDM2-P53 inhibitors |
| WO2016001376A1 (en) | 2014-07-03 | 2016-01-07 | Boehringer Ingelheim International Gmbh | New spiro[3h-indole-3,2´-pyrrolidin]-2(1h)-one compounds and derivatives as mdm2-p53 inhibitors |
| PT3183254T (pt) | 2014-08-21 | 2019-08-29 | Boehringer Ingelheim Int | Novos compostos de espiro[3h-indole-3,2¿-pirrolidin]-2(1h)-ona e derivados como inibidores de mdm2-p53 |
| EP3206711B1 (en) | 2014-10-14 | 2023-05-31 | Novartis AG | Antibody molecules to pd-l1 and uses thereof |
| EP3233918A1 (en) * | 2014-12-19 | 2017-10-25 | Novartis AG | Combination therapies |
| WO2016205566A1 (en) * | 2015-06-16 | 2016-12-22 | The Regents Of The University Of California | Fzd7 specific antibodies and vaccines to treat cancer and control stem cell function |
| EP3317301B1 (en) * | 2015-07-29 | 2021-04-07 | Novartis AG | Combination therapies comprising antibody molecules to lag-3 |
| CN114272371A (zh) | 2015-07-29 | 2022-04-05 | 诺华股份有限公司 | 包含抗pd-1抗体分子的联合疗法 |
| TWI737635B (zh) * | 2015-10-09 | 2021-09-01 | 德商百靈佳殷格翰國際股份有限公司 | 作為mdm2－p53抑制劑之新穎螺﹝3h－吲哚－3，2´－吡咯啶﹞－2（1h）－酮化合物及其衍生物 |
| IL262892B2 (en) * | 2016-05-18 | 2024-04-01 | Boehringer Ingelheim Int | Anti pd-1 and anti-lag3 antibodies for cancer treatment |
| WO2019063802A1 (en) * | 2017-09-29 | 2019-04-04 | Boehringer Ingelheim International Gmbh | ANTICANCER ANTI-IGF POLY THERAPY, ANTI PD-1 |
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2018
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- 2018-04-04 JP JP2019554792A patent/JP2020516604A/ja not_active Ceased
- 2018-04-04 BR BR112019021032A patent/BR112019021032A2/pt unknown
- 2018-04-04 CN CN201880023850.XA patent/CN110505884B/zh active Active
- 2018-04-04 CN CN202210548008.6A patent/CN114949228A/zh active Pending
- 2018-04-04 US US16/500,572 patent/US20200101079A1/en not_active Abandoned
- 2018-04-04 KR KR1020197032689A patent/KR20190132687A/ko not_active Ceased
- 2018-04-04 CA CA3057558A patent/CA3057558A1/en active Pending
- 2018-04-04 EP EP18715685.6A patent/EP3606556A1/en not_active Withdrawn
- 2018-04-04 MX MX2019011945A patent/MX2019011945A/es unknown
- 2018-04-04 WO PCT/EP2018/058562 patent/WO2018185135A1/en not_active Ceased
- 2018-04-04 AU AU2018248586A patent/AU2018248586A1/en not_active Abandoned
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2019
- 2019-10-01 CL CL2019002800A patent/CL2019002800A1/es unknown
- 2019-10-04 PH PH12019502291A patent/PH12019502291A1/en unknown
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2022
- 2022-07-15 US US17/812,735 patent/US20230025452A1/en not_active Abandoned
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2023
- 2023-10-02 CL CL2023002946A patent/CL2023002946A1/es unknown
- 2023-12-18 JP JP2023212944A patent/JP2024029009A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| BR112019021032A2 (pt) | 2020-05-05 |
| AU2018248586A1 (en) | 2019-09-05 |
| CL2023002946A1 (es) | 2024-04-19 |
| CN110505884A (zh) | 2019-11-26 |
| JP2020516604A (ja) | 2020-06-11 |
| EP4368200A2 (en) | 2024-05-15 |
| US20200101079A1 (en) | 2020-04-02 |
| MX2019011945A (es) | 2019-11-28 |
| KR20190132687A (ko) | 2019-11-28 |
| EP3606556A1 (en) | 2020-02-12 |
| CN114949228A (zh) | 2022-08-30 |
| CA3057558A1 (en) | 2018-10-11 |
| US20230025452A1 (en) | 2023-01-26 |
| CL2019002800A1 (es) | 2020-03-06 |
| CN110505884B (zh) | 2022-08-12 |
| JP2024029009A (ja) | 2024-03-05 |
| EP4368200A3 (en) | 2024-07-17 |
| PH12019502291A1 (en) | 2020-07-06 |
| WO2018185135A1 (en) | 2018-10-11 |
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