KR20240052937A - 이치환된 1, 2, 4-트리아진 화합물의 염을 포함하는 가용성 약제학적 조성물 - Google Patents

이치환된 1, 2, 4-트리아진 화합물의 염을 포함하는 가용성 약제학적 조성물 Download PDF

Info

Publication number
KR20240052937A
KR20240052937A KR1020247005631A KR20247005631A KR20240052937A KR 20240052937 A KR20240052937 A KR 20240052937A KR 1020247005631 A KR1020247005631 A KR 1020247005631A KR 20247005631 A KR20247005631 A KR 20247005631A KR 20240052937 A KR20240052937 A KR 20240052937A
Authority
KR
South Korea
Prior art keywords
pharmaceutical composition
compound
salt
milligrams
excipients
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
KR1020247005631A
Other languages
English (en)
Korean (ko)
Inventor
로버트 맥킨
요시노리 오하시
후미노리 오자키
히로키 오시마
히루미 나가타
로크 티베르트
엘리자베스 바다스
Original Assignee
미네랄리스 테라퓨틱스, 아이엔씨.
미쓰비시 타나베 파마 코퍼레이션
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 미네랄리스 테라퓨틱스, 아이엔씨., 미쓰비시 타나베 파마 코퍼레이션 filed Critical 미네랄리스 테라퓨틱스, 아이엔씨.
Publication of KR20240052937A publication Critical patent/KR20240052937A/ko
Pending legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2009—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
    • A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/485—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Inorganic Chemistry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
KR1020247005631A 2021-07-20 2022-07-20 이치환된 1, 2, 4-트리아진 화합물의 염을 포함하는 가용성 약제학적 조성물 Pending KR20240052937A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202163223711P 2021-07-20 2021-07-20
US63/223,711 2021-07-20
PCT/IB2022/056709 WO2023002407A2 (en) 2021-07-20 2022-07-20 Soluble pharmaceutical compositions comprising salts of disubstituted 1, 2, 4-triazine compound

Publications (1)

Publication Number Publication Date
KR20240052937A true KR20240052937A (ko) 2024-04-23

Family

ID=84978780

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020247005631A Pending KR20240052937A (ko) 2021-07-20 2022-07-20 이치환된 1, 2, 4-트리아진 화합물의 염을 포함하는 가용성 약제학적 조성물

Country Status (6)

Country Link
US (1) US20240366616A1 (https=)
EP (1) EP4373812A4 (https=)
JP (1) JP2024525954A (https=)
KR (1) KR20240052937A (https=)
CN (1) CN117957213A (https=)
WO (1) WO2023002407A2 (https=)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20230069126A (ko) * 2020-09-15 2023-05-18 미쓰비시 타나베 파마 코퍼레이션 트리아진 화합물의 염, 그 결정형 및 제조 방법

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201212866D0 (en) * 2012-07-20 2012-09-05 Formac Pharmaceuticals Nv Dry granulates of mesoporous silica powders
MY176401A (en) * 2014-04-24 2020-08-05 Mitsubishi Tanabe Pharma Corp Novel disubstituted 1,2,4-triazine compound
KR20230069126A (ko) * 2020-09-15 2023-05-18 미쓰비시 타나베 파마 코퍼레이션 트리아진 화합물의 염, 그 결정형 및 제조 방법
JP2023546970A (ja) * 2020-10-26 2023-11-08 ミネラリス・セラピューティクス・インコーポレイテッド 高血圧のためのｃｙｐ１１ｂ２ベータヒドロキシラーゼ阻害剤

Also Published As

Publication number Publication date
CN117957213A (zh) 2024-04-30
EP4373812A4 (en) 2025-05-14
EP4373812A2 (en) 2024-05-29
WO2023002407A3 (en) 2023-03-09
US20240366616A1 (en) 2024-11-07
WO2023002407A2 (en) 2023-01-26
JP2024525954A (ja) 2024-07-12

Similar Documents

Publication Publication Date Title
US20220110908A1 (en) Low-Dose Doxepin Formulations And Methods Of Making And Using The Same
WO2006072878A1 (en) Oral dosage forms of sertraline having controlled particle size and processes for their preparation
US20200261416A1 (en) Pharmaceutical compositions of apremilast
WO2005097078A1 (en) Compressed composition comprising magnesium salt
KR20160054216A (ko) 콜린알포세레이트를 함유하는 정제 및 그 제조방법
EP4424373B1 (en) Pharmaceutical compositions containing doravirine, tenofovir disoproxil fumarate and lamivudine
EP2323634B1 (en) Ropinirole composition
CA3013161C (en) Oral dosage form comprising rifaximin in form beta
KR20240052937A (ko) 이치환된 1, 2, 4-트리아진 화합물의 염을 포함하는 가용성 약제학적 조성물
JP2020121950A (ja) 固形製剤
US20110112160A1 (en) Tablet comprising eprosartan mesylate
US20200276129A1 (en) Tablet containing valsartan and sacubitril
WO2018153977A1 (en) Stable composition of tenofovir alafenamide
CN112999181A (zh) 一种富马酸沃诺拉赞片剂
JP2022012138A (ja) リナグリプチンと光安定化成分を含有する医薬製剤
WO2013091595A1 (en) Pharmaceutical formulation of prasugrel hydrobromide
JP6765473B2 (ja) オルメサルタンのプロドラッグ製剤
HK40103672A (zh) 包括经二取代的1，2，4-三嗪化合物的盐的可溶性药物组合物
TW202222310A (zh) 用於治療或預防高血壓和高血脂症之單一劑型的藥學組成物
EP3641735B1 (en) Pharmaceutical tablet composition comprising bilastine form 3 and a water-soluble filler
EP3501609A1 (en) Pharmaceutical compositions comprising ibrutinib
EP2554164B1 (en) Pharmaceutical formulation based on ibuprofen and codeine having having improved stability
EP4279075A1 (en) A pharmaceutical composition comprising elagolix
WO2024126409A1 (en) Pharmaceutical composition of siponimod
CA3237792A1 (en) Pharmaceutical composition having excellent dissolution properties

Legal Events

Date Code Title Description
PA0105 International application

St.27 status event code: A-0-1-A10-A15-nap-PA0105

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

PG1501 Laying open of application

St.27 status event code: A-1-1-Q10-Q12-nap-PG1501

E13 Pre-grant limitation requested

Free format text: ST27 STATUS EVENT CODE: A-2-3-E10-E13-LIM-X000 (AS PROVIDED BY THE NATIONAL OFFICE)

E13-X000 Pre-grant limitation requested

St.27 status event code: A-2-3-E10-E13-lim-X000

P11 Amendment of application requested

Free format text: ST27 STATUS EVENT CODE: A-2-2-P10-P11-NAP-X000 (AS PROVIDED BY THE NATIONAL OFFICE)

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

PN2301 Change of applicant

St.27 status event code: A-3-3-R10-R13-asn-PN2301

St.27 status event code: A-3-3-R10-R11-asn-PN2301

R11 Change to the name of applicant or owner or transfer of ownership requested

Free format text: ST27 STATUS EVENT CODE: A-3-3-R10-R11-ASN-PN2301 (AS PROVIDED BY THE NATIONAL OFFICE)

R13 Change to the name of applicant or owner recorded

Free format text: ST27 STATUS EVENT CODE: A-3-3-R10-R13-ASN-PN2301 (AS PROVIDED BY THE NATIONAL OFFICE)