KR20240019083A - 트리아진 유도체 및 암 치료에서 이의 용도 - Google Patents

트리아진 유도체 및 암 치료에서 이의 용도 Download PDF

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Publication number
KR20240019083A
KR20240019083A KR1020237039328A KR20237039328A KR20240019083A KR 20240019083 A KR20240019083 A KR 20240019083A KR 1020237039328 A KR1020237039328 A KR 1020237039328A KR 20237039328 A KR20237039328 A KR 20237039328A KR 20240019083 A KR20240019083 A KR 20240019083A
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KR
South Korea
Prior art keywords
methyl
triazin
amino
piperidyl
phenol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
KR1020237039328A
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English (en)
Korean (ko)
Inventor
레아 오렐리 부슈
볼프강 구바
게오르그 얘쉬케
스테파니 카타리나 메쉬
안젤리크 파티니-아담
크리스티안 슈나이더
산드라 스타이너
안드레아스 미하엘 토쓰토르프
Original Assignee
에프. 호프만-라 로슈 아게
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Application filed by 에프. 호프만-라 로슈 아게 filed Critical 에프. 호프만-라 로슈 아게
Publication of KR20240019083A publication Critical patent/KR20240019083A/ko
Pending legal-status Critical Current

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D253/00Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
    • C07D253/02Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
    • C07D253/061,2,4-Triazines
    • C07D253/0651,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
    • C07D253/071,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pulmonology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
KR1020237039328A 2021-06-04 2022-06-02 트리아진 유도체 및 암 치료에서 이의 용도 Pending KR20240019083A (ko)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
EP21177660 2021-06-04
EP21177660.4 2021-06-04
EP21188639 2021-07-30
EP21188639.5 2021-07-30
EP21215875 2021-12-20
EP21215875.2 2021-12-20
PCT/EP2022/064995 WO2022253936A1 (en) 2021-06-04 2022-06-02 Triazine derivatives and their use in the treatment of cancer.

Publications (1)

Publication Number Publication Date
KR20240019083A true KR20240019083A (ko) 2024-02-14

Family

ID=82115763

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020237039328A Pending KR20240019083A (ko) 2021-06-04 2022-06-02 트리아진 유도체 및 암 치료에서 이의 용도

Country Status (16)

Country Link
US (3) US20240132471A1 (https=)
EP (1) EP4347571B1 (https=)
JP (2) JP7705963B2 (https=)
KR (1) KR20240019083A (https=)
AR (1) AR126053A1 (https=)
AU (1) AU2022287224A1 (https=)
BR (1) BR112023025318A2 (https=)
CA (1) CA3216026A1 (https=)
CL (1) CL2023003491A1 (https=)
CO (1) CO2023016212A2 (https=)
CR (1) CR20230566A (https=)
IL (1) IL307201A (https=)
MX (1) MX2023013998A (https=)
PE (1) PE20240928A1 (https=)
TW (1) TW202313577A (https=)
WO (1) WO2022253936A1 (https=)

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US11618751B1 (en) 2022-03-25 2023-04-04 Ventus Therapeutics U.S., Inc. Pyrido-[3,4-d]pyridazine amine derivatives useful as NLRP3 derivatives
US11319319B1 (en) 2021-04-07 2022-05-03 Ventus Therapeutics U.S., Inc. Compounds for inhibiting NLRP3 and uses thereof
CA3218212A1 (en) * 2021-04-28 2022-11-03 Astellas Pharma Inc. Substituted triazine compound
TW202313577A (zh) * 2021-06-04 2023-04-01 瑞士商赫孚孟拉羅股份公司 新穎化合物
IL314025A (en) * 2022-01-07 2024-08-01 Transthera Sciences Nanjing Inc Nlrp3 inflammasome inhibitor and uses thereof
EP4558499A1 (en) * 2022-07-21 2025-05-28 F. Hoffmann-La Roche AG Nlrp3 inhibitors
US12331048B2 (en) 2022-10-31 2025-06-17 Ventus Therapeutics U.S., Inc. Pyrido-[3,4-d]pyridazine amine derivatives useful as NLRP3 inhibitors
AU2023371859A1 (en) * 2022-11-04 2025-06-12 Transthera Sciences (Nanjing) , Inc. Nlrp3 inflammasome inhibitor and use thereof
PE20251845A1 (es) * 2022-12-07 2025-07-17 Hoffmann La Roche Compuestos novedosos como moduladores de la inhibicion de nlrp3
JP2026511027A (ja) * 2023-03-20 2026-04-10 インシリコ メディスン アイピー リミティド Nlrp3インフラマソーム阻害剤及びその使用
WO2024193699A1 (zh) * 2023-03-23 2024-09-26 成都赜灵生物医药科技有限公司 三嗪类化合物及其用途
TW202448448A (zh) * 2023-04-19 2024-12-16 瑞士商赫孚孟拉羅股份公司 新穎化合物
AU2024258000A1 (en) * 2023-04-19 2025-08-14 F. Hoffmann-La Roche Ag Oxazolo[4,5-b]pyrazine and oxazolo[4,5-b]pyridine derivatives as nlrp3 inhibitors for the treatment of e.g. inflammatory diseases
KR20260027946A (ko) 2023-06-02 2026-03-03 머크 샤프 앤드 돔 엘엘씨 Nod-유사 수용체 단백질 3의 억제제로서 유용한 5,6 불포화 비시클릭 헤테로사이클
CN121586712A (zh) * 2023-07-28 2026-02-27 豪夫迈·罗氏有限公司 新颖化合物
WO2025046419A1 (ko) * 2023-08-25 2025-03-06 제일약품주식회사 Nlrp3 저해제로서의 신규한 화합물 및 이를 포함하는 약학적 조성물
WO2025153532A1 (en) 2024-01-16 2025-07-24 NodThera Limited Nlrp3 inhibitors and glp-1 agonists combination therapies
WO2025252772A1 (en) * 2024-06-06 2025-12-11 F. Hoffmann-La Roche Ag Triazine derivatives
WO2026046981A1 (en) 2024-08-28 2026-03-05 F. Hoffmann-La Roche Ag Solid forms of 5-[3-[[(3r)-1-ethyl-3-piperidyl]amino]-5-methyl-1,2,4-triazin-6-yl]-2,3- dihydrobenzofuran-4-ol

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WO2019028440A1 (en) * 2017-08-04 2019-02-07 Skyhawk Therapeutics, Inc. METHODS AND COMPOSITIONS FOR MODULATING SPLICING
MX2020001776A (es) 2017-08-15 2020-03-24 Inflazome Ltd Sulfonilureas y sulfoniltioureas como inhibidores de nlrp3.
KR20200087759A (ko) 2017-11-09 2020-07-21 인플라좀 리미티드 신규한 설폰아마이드 카복스아마이드 화합물
MX2020009957A (es) * 2018-03-27 2021-01-15 Ptc Therapeutics Inc Compuestos para el tratamiento de enfermedad de hungtinton.
KR20210038877A (ko) 2018-07-25 2021-04-08 노파르티스 아게 Nlrp3 인플라마좀 억제제
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WO2022135567A1 (zh) 2020-12-25 2022-06-30 上海拓界生物医药科技有限公司 一类含哒嗪的化合物及其医药用途
EP4289823A4 (en) 2021-02-08 2025-02-26 Medshine Discovery Inc. SUBSTITUTED PYRIDAZINE PHENOL DERIVATIVES
US11319319B1 (en) 2021-04-07 2022-05-03 Ventus Therapeutics U.S., Inc. Compounds for inhibiting NLRP3 and uses thereof
CA3218212A1 (en) 2021-04-28 2022-11-03 Astellas Pharma Inc. Substituted triazine compound
TW202313577A (zh) * 2021-06-04 2023-04-01 瑞士商赫孚孟拉羅股份公司 新穎化合物
CN115433163A (zh) 2021-06-05 2022-12-06 药捷安康(南京)科技股份有限公司 Nlrp3炎症小体抑制剂及其应用
LT4363406T (lt) 2021-07-02 2025-12-29 Astrazeneca Ab Nlrp3 inflamasomų inhibitoriai
WO2023028536A1 (en) 2021-08-25 2023-03-02 Ptc Therapeutics, Inc. 1,2,4-triazine derivatives useful as inhibitors of nlrp3
WO2023066377A1 (zh) 2021-10-22 2023-04-27 索智生物科技(浙江)有限公司 一种含氮化合物、其制备方法及应用
IL314025A (en) 2022-01-07 2024-08-01 Transthera Sciences Nanjing Inc Nlrp3 inflammasome inhibitor and uses thereof
CA3246681A1 (en) 2022-03-25 2023-09-28 Ventus Therapeutics U.S., Inc. PYRIDO-[3,4-D]PYRIDAZINE AMINE DERIVATIVES USEFUL AS NLRP3 DERIVATIVES
JPWO2024090469A1 (https=) 2022-10-26 2024-05-02
CN115621720A (zh) * 2022-10-27 2023-01-17 永道射频技术股份有限公司 一种应用于rfid读写器的全息超材料阵列天线
AU2023371859A1 (en) 2022-11-04 2025-06-12 Transthera Sciences (Nanjing) , Inc. Nlrp3 inflammasome inhibitor and use thereof
TW202440107A (zh) 2022-12-28 2024-10-16 瑞典商阿斯特捷利康公司 Nlrp3炎症小體抑制劑
WO2024169858A1 (zh) 2023-02-17 2024-08-22 成都赜灵生物医药科技有限公司 六元氮杂环类化合物及其用途

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Publication number Publication date
JP2025098157A (ja) 2025-07-01
US12421209B2 (en) 2025-09-23
US20240132471A1 (en) 2024-04-25
CO2023016212A2 (es) 2023-12-11
US20250276958A1 (en) 2025-09-04
TW202313577A (zh) 2023-04-01
JP2024522494A (ja) 2024-06-21
CL2023003491A1 (es) 2024-05-24
AR126053A1 (es) 2023-09-06
US20250197370A1 (en) 2025-06-19
CA3216026A1 (en) 2022-12-08
MX2023013998A (es) 2023-12-11
EP4347571A1 (en) 2024-04-10
IL307201A (en) 2023-11-01
JP7705963B2 (ja) 2025-07-10
PE20240928A1 (es) 2024-04-30
EP4347571B1 (en) 2026-04-22
BR112023025318A2 (pt) 2024-02-27
CR20230566A (es) 2024-01-22
WO2022253936A1 (en) 2022-12-08
AU2022287224A1 (en) 2023-09-21

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PA0105 International application

Patent event date: 20231115

Patent event code: PA01051R01D

Comment text: International Patent Application

PG1501 Laying open of application
A201 Request for examination
PA0201 Request for examination

Patent event code: PA02012R01D

Patent event date: 20250408

Comment text: Request for Examination of Application