JP7705963B2 - トリアジン誘導体およびがんの処置におけるその使用 - Google Patents

トリアジン誘導体およびがんの処置におけるその使用 Download PDF

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Publication number
JP7705963B2
JP7705963B2 JP2023572751A JP2023572751A JP7705963B2 JP 7705963 B2 JP7705963 B2 JP 7705963B2 JP 2023572751 A JP2023572751 A JP 2023572751A JP 2023572751 A JP2023572751 A JP 2023572751A JP 7705963 B2 JP7705963 B2 JP 7705963B2
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methyl
mmol
equiv
triazin
disease
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JP2024522494A (ja
JP2024522494A5 (https=
Inventor
ブッシュ，レア・オレリー
グーバ，ヴォルフガング
ヤーシュケ，ゲオルク
メッシュ，ステファニー・カタリナ
パティニー－アダム，アンジェリーク
シュナイダー，クリスティアン
シュタイナー，サンドラ
トストルフ，アンドレアス・ミシェル
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F Hoffmann La Roche AG
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F Hoffmann La Roche AG
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
    • C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
    • C07D253/06—1,2,4-Triazines
    • C07D253/065—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
    • C07D253/07—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pulmonology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP2023572751A 2021-06-04 2022-06-02 トリアジン誘導体およびがんの処置におけるその使用 Active JP7705963B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2025051003A JP2025098157A (ja) 2021-06-04 2025-03-26 トリアジン誘導体およびがんの処置におけるその使用

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
EP21177660 2021-06-04
EP21177660.4 2021-06-04
EP21188639 2021-07-30
EP21188639.5 2021-07-30
EP21215875 2021-12-20
EP21215875.2 2021-12-20
PCT/EP2022/064995 WO2022253936A1 (en) 2021-06-04 2022-06-02 Triazine derivatives and their use in the treatment of cancer.

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JP2025051003A Division JP2025098157A (ja) 2021-06-04 2025-03-26 トリアジン誘導体およびがんの処置におけるその使用

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JP2024522494A JP2024522494A (ja) 2024-06-21
JP2024522494A5 JP2024522494A5 (https=) 2025-04-03
JP7705963B2 true JP7705963B2 (ja) 2025-07-10

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JP2025051003A Pending JP2025098157A (ja) 2021-06-04 2025-03-26 トリアジン誘導体およびがんの処置におけるその使用

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US (3) US20240132471A1 (https=)
EP (1) EP4347571B1 (https=)
JP (2) JP7705963B2 (https=)
KR (1) KR20240019083A (https=)
AR (1) AR126053A1 (https=)
AU (1) AU2022287224A1 (https=)
BR (1) BR112023025318A2 (https=)
CA (1) CA3216026A1 (https=)
CL (1) CL2023003491A1 (https=)
CO (1) CO2023016212A2 (https=)
CR (1) CR20230566A (https=)
IL (1) IL307201A (https=)
MX (1) MX2023013998A (https=)
PE (1) PE20240928A1 (https=)
TW (1) TW202313577A (https=)
WO (1) WO2022253936A1 (https=)

Cited By (1)

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JP2025098157A (ja) * 2021-06-04 2025-07-01 エフ． ホフマン－ラ ロシュ アーゲー トリアジン誘導体およびがんの処置におけるその使用

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US11618751B1 (en) 2022-03-25 2023-04-04 Ventus Therapeutics U.S., Inc. Pyrido-[3,4-d]pyridazine amine derivatives useful as NLRP3 derivatives
US11319319B1 (en) 2021-04-07 2022-05-03 Ventus Therapeutics U.S., Inc. Compounds for inhibiting NLRP3 and uses thereof
CA3218212A1 (en) * 2021-04-28 2022-11-03 Astellas Pharma Inc. Substituted triazine compound
IL314025A (en) * 2022-01-07 2024-08-01 Transthera Sciences Nanjing Inc Nlrp3 inflammasome inhibitor and uses thereof
EP4558499A1 (en) * 2022-07-21 2025-05-28 F. Hoffmann-La Roche AG Nlrp3 inhibitors
US12331048B2 (en) 2022-10-31 2025-06-17 Ventus Therapeutics U.S., Inc. Pyrido-[3,4-d]pyridazine amine derivatives useful as NLRP3 inhibitors
AU2023371859A1 (en) * 2022-11-04 2025-06-12 Transthera Sciences (Nanjing) , Inc. Nlrp3 inflammasome inhibitor and use thereof
PE20251845A1 (es) * 2022-12-07 2025-07-17 Hoffmann La Roche Compuestos novedosos como moduladores de la inhibicion de nlrp3
JP2026511027A (ja) * 2023-03-20 2026-04-10 インシリコ メディスン アイピー リミティド Ｎｌｒｐ３インフラマソーム阻害剤及びその使用
WO2024193699A1 (zh) * 2023-03-23 2024-09-26 成都赜灵生物医药科技有限公司 三嗪类化合物及其用途
TW202448448A (zh) * 2023-04-19 2024-12-16 瑞士商赫孚孟拉羅股份公司 新穎化合物
AU2024258000A1 (en) * 2023-04-19 2025-08-14 F. Hoffmann-La Roche Ag Oxazolo[4,5-b]pyrazine and oxazolo[4,5-b]pyridine derivatives as nlrp3 inhibitors for the treatment of e.g. inflammatory diseases
KR20260027946A (ko) 2023-06-02 2026-03-03 머크 샤프 앤드 돔 엘엘씨 Nod-유사 수용체 단백질 3의 억제제로서 유용한 5,6 불포화 비시클릭 헤테로사이클
CN121586712A (zh) * 2023-07-28 2026-02-27 豪夫迈·罗氏有限公司 新颖化合物
WO2025046419A1 (ko) * 2023-08-25 2025-03-06 제일약품주식회사 Nlrp3 저해제로서의 신규한 화합물 및 이를 포함하는 약학적 조성물
WO2025153532A1 (en) 2024-01-16 2025-07-24 NodThera Limited Nlrp3 inhibitors and glp-1 agonists combination therapies
WO2025252772A1 (en) * 2024-06-06 2025-12-11 F. Hoffmann-La Roche Ag Triazine derivatives
WO2026046981A1 (en) 2024-08-28 2026-03-05 F. Hoffmann-La Roche Ag Solid forms of 5-[3-[[(3r)-1-ethyl-3-piperidyl]amino]-5-methyl-1,2,4-triazin-6-yl]-2,3- dihydrobenzofuran-4-ol

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Publication number Priority date Publication date Assignee Title
JP2025098157A (ja) * 2021-06-04 2025-07-01 エフ． ホフマン－ラ ロシュ アーゲー トリアジン誘導体およびがんの処置におけるその使用

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JP2025098157A (ja) 2025-07-01
US12421209B2 (en) 2025-09-23
US20240132471A1 (en) 2024-04-25
CO2023016212A2 (es) 2023-12-11
US20250276958A1 (en) 2025-09-04
TW202313577A (zh) 2023-04-01
JP2024522494A (ja) 2024-06-21
CL2023003491A1 (es) 2024-05-24
AR126053A1 (es) 2023-09-06
KR20240019083A (ko) 2024-02-14
US20250197370A1 (en) 2025-06-19
CA3216026A1 (en) 2022-12-08
MX2023013998A (es) 2023-12-11
EP4347571A1 (en) 2024-04-10
IL307201A (en) 2023-11-01
PE20240928A1 (es) 2024-04-30
EP4347571B1 (en) 2026-04-22
BR112023025318A2 (pt) 2024-02-27
CR20230566A (es) 2024-01-22
WO2022253936A1 (en) 2022-12-08
AU2022287224A1 (en) 2023-09-21

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