KR20240006925A - Food composition for improving alopecia and improving Liver function - Google Patents

Abstract

The present invention relates to a food composition for improving liver function and preventing and improving hair loss, and more specifically, to a food composition for improving liver function, preventing and improving hair loss, and more specifically, chaga mushroom, thistle, goldenrod, Macmundong, reishi mushroom, mugwort, garlic, ginkgo, western mountain lion, seaweed, kelp, sea lettuce, It is characterized by containing seaweed, pine needles, beta-carotene, and vitamins as active ingredients. According to the present invention, there are advantages of improving liver function, effectively preventing and improving alopecia, and promoting hair growth without causing side effects.

Description

Food composition for improving liver function, preventing and improving hair loss in the telogen or anagen phase {Food composition for improving alopecia and improving Liver function}

The present invention relates to a food composition for improving liver function and preventing and improving hair loss in the telogen or anagen phase, and more specifically, to a food composition for improving liver function, preventing and improving hair loss in the telogen or anagen phase, and more specifically, chaga mushroom, thistle, goldenrod, maekmundong, reishi mushroom, mugwort, garlic, ginkgo, western mountain lion, seaweed, and kelp. It relates to a food composition that not only improves liver function through green seaweed, seaweed, pine needles, etc., but also prevents and improves telogen or anagen alopecia.

Hair is made from hair follicles, and each hair follicle periodically goes through stages of activity and quiescence. The time interval of this hair cycle varies depending on the body part. In the case of hair, it goes through a growth phase (growth phase) of about 26 years, a catagen phase of 2 to 4 weeks, and then a resting phase of about 3 to 4 months. Each hair follicle has 10 to 20 hair follicle growth cycles throughout its life. In a normal person, the number of hairs on the head is about 100,000, and the hair grows at an average of 1 cm per month. Normally, 85-90% of all normal hair is in the growth phase, and as we age, the number of hair follicles in the growth phase decreases. Generally, 10 to 15% of hair follicles are in the catagen or telogen stage, and an average of 50 to 60 hairs are normally lost per day. If more than 100 hairs are lost per day, it can be considered alopecia.

Alopecia refers to a condition where there is no hair where hair should normally be. Hair plays a significant role from a cosmetic perspective, and has other functions such as blocking ultraviolet rays and protecting the hair. Hair loss can be clinically divided into cicatricial alopecia, which is accompanied by scarring, and non-scarring alopecia, where only hair is lost. Among these, cicatricial alopecia is accompanied by a major problem in that hair follicles are destroyed and hair is not regenerated. Therefore, the application of hair loss treatments or prevention agents focuses on cicatricial hair loss.

Additionally, if heat builds up in the liver due to excessive stress or medication, the heat moves to the head and promotes hair loss.

Meanwhile, currently well-known anti-hair loss agents include Minoxidil, an external skin agent approved by the FDA, oral finasteride, and Dutasteride, approved by Korea's MFDS. There is strong speculation that minoxidil follows the mechanism of supplying nutrients to hair follicles by dilating blood vessels through hyperpolarization of the cell membrane, but research has also shown that minoxidil can act directly on human hair follicle cells to activate the signal of beta-catenin, a representative proliferation mechanism. was published (Kwack MH et al, J Dermatol Sci, 62(3):154-159, 2011). Finasteride and dutasteride are known to have a mechanism that inhibits the production of DHT, which causes hair loss, by inhibiting 5α-Reductase, which converts testosterone into DHT (Yamana K et al, Horm Mol Biol Clin Investig, 1 ;2(3):293-299, 2010; Clark RV et al, J Clin Endocrnol Metab, 89(5):2179-2184, 2004).

However, these chemical anti-hair loss agents require continuous prescription because their effectiveness disappears when discontinued. They have various side effects such as dermatitis, decreased libido, and induction of gynecomastia, so research into natural anti-hair loss agents is continuing.

KR 10-0958496 B1 KR 10-2242151 B1

Therefore, the purpose of the present invention is to provide a food composition that strengthens liver function and prevents and improves alopecia by using ingredients derived from natural products without causing side effects.

The food composition for improving liver function and preventing and improving hair loss according to the present invention for achieving the above-mentioned objectives includes chaga mushroom, thistle, goldenrod, maekmundong, reishi mushroom, mugwort, garlic, ginkgo, western mountain lion, seaweed, kelp, and seaweed. , seaweed, pine needles, beta-carotene, and vitamins as active ingredients.

The vitamins include one or more of vitamin D3, vitamin B2, vitamin B3, vitamin B6 hydrochloride, and vitamin C,

For 100 parts by weight of the above chaga mushrooms, 30-70 parts by weight of thistle, 10-30 parts by weight of gold, 10-30 parts by weight of Macmundong, 50-100 parts by weight of reishi mushroom, 10-30 parts by weight of mugwort, 10-30 parts by weight of garlic. 10-30 parts by weight, ginkgo 10-30 parts by weight, 10-30 parts by weight of western mountain lion, 10-30 parts by weight of seaweed, 10-30 parts by weight of kelp, 10-30 parts by weight of green seaweed, 10-30 parts by weight, 10-30 parts by weight of pine needles. It is characterized in that it contains 1 to 10 parts by weight of beta-carotene and 1 to 10 parts by weight of vitamins as active ingredients.

It is characterized in that it further contains Rosa davurica stem extract and Stone water parsley extract as active ingredients.

It is characterized in that it further contains Asparagopsis taxiformis extract and Martensia jejuensis extract as active ingredients.

According to the food composition for improving liver function and preventing and improving hair loss according to the present invention, it has the advantage of improving liver function, effectively preventing and improving alopecia, and promoting hair growth without causing side effects.

1 is a graph showing the results of Test Example 2 according to the present invention.

Hereinafter, the present invention will be described in detail.

The food composition for improving liver function, preventing and improving hair loss according to the present invention has no side effects by using natural materials, improves liver function, and prevents alopecia, especially telogen or anagen alopecia caused by a decrease in liver function. It is characterized by effective prevention and improvement.

The food composition for improving liver function and preventing and improving hair loss according to the present invention includes chaga mushroom, thistle, goldenrod, maekmundong, reishi mushroom, mugwort, garlic, ginkgo, western mountain lion, seaweed, kelp, seaweed, seaweed, pine needle, It is characterized by containing beta-carotene and vitamins as active ingredients.

Chaga is a medicinal mushroom that grows on birch trees. It contains an ingredient called inositol, which relieves hair loss symptoms caused by hormonal imbalance and plays a role in protecting the liver. In addition, beta-glucan is also abundant, which plays a role in enhancing immunity.

The ussuri thistle is rich in flavonoids, which helps improve fatty liver disease, and is also rich in silymarin, which plays a role in regenerating damaged liver cells. It also improves chronic fatigue caused by excessive stress. In the present invention, one or more of the roots, stems, and leaves of thistle are used.

The gold (Scutellariae Radix) is a medicinal herb made from dried golden roots. It is cold in nature, reduces scalp fever, prevents hair loss, and provides excellent antibacterial and anti-inflammatory effects.

Liriope platyphylla Wang et Tang is a medicinal herb made from the dried roots. It has a cold nature, so it reduces scalp fever, promotes blood flow, and enhances immunity to prevent and improve hair loss.

The reishi mushroom (Ganoderma lucidum Karsten) is rich in glucan components that boost immunity, so it not only prevents hair loss by improving immunity, but also has excellent anti-inflammatory effects, reduces liver fatigue, and promotes the regeneration of liver cells to prevent hair loss. and plays a role in improving it.

Artemisia capillaris Thunb. is a perennial herb growing in Korea belonging to the Compositae family and is known to contain coumarin derivatives such as esculetin, scoparone and scopoletin, especially copoletin and scopoletin. Retin is the main active ingredient and has been reported to exhibit anti-inflammatory activity. In addition, mugwort removes fire from the liver and promotes the regeneration of liver cells, thereby preventing hair loss.

The garlic (Allium sativum for. pekinese) has excellent antibacterial and anti-inflammatory effects, strengthens immunity, reduces liver fatigue, promotes regeneration of liver cells, purifies the blood, stimulates the nervous system, promotes blood circulation, and prevents hair loss. It plays a role in preventing and improving.

The ginkgo is a fruit of the ginkgo tree, and plays a role in smoothing lung function through detoxification of the lungs and promoting blood circulation. In the present invention, the external skin of the ginkgo is removed and used.

The Western mountain lion (C. oxyacantha L.) refers to the fruit of a Rosaceae plant that grows in European forests, and plays a role in strengthening the heart muscle and dilating blood vessels to promote blood circulation.

The seaweed, kelp, seaweed, and seaweed are rich in minerals such as iodine, calcium, iron, and phosphorus, and play a role in preventing hair loss by supplying nutrients to the scalp, promoting blood circulation, and maintaining normal secretion of hormones. Do it.

The pine needles have an antibacterial effect, reduce heat in the scalp, and promote blood circulation to prevent hair loss.

The beta-carotene and vitamins are essential nutrients necessary for the metabolic process of cells, and ensure proper supply of nutrients to the hair papilla.

In the present invention, the vitamins may include one or more of vitamin D3, vitamin B2, vitamin B3, vitamin B6 hydrochloride, and vitamin C, and most preferably include all of them.

At this time, the chaga mushroom, thistle, goldenrod, maekmundong, reishi mushroom, mugwort, garlic, ginkgo, western mountain lion, seaweed, kelp, seaweed, seaweed and pine needles may be included in the form of dried powder or in the form of extract. It may be possible.

In the present invention, the drying method and extraction method are not limited. However, the extract is preferably obtained by extracting each material using water, ethanol, or a mixed solution thereof as a solvent. Since this method of extracting natural products is well known in the field to which this technology belongs, detailed description thereof will be omitted. And it goes without saying that the extract can be concentrated or dried as needed.

In addition, in the present invention, for 100 parts by weight of the chaga mushroom, 30 to 70 parts by weight of thistle, 10 to 30 parts by weight of gold, 10 to 30 parts by weight of Macmundong, 50 to 100 parts by weight of reishi mushroom, 10 to 30 parts by weight of mugwort, 10-30 parts by weight of garlic, 10-30 parts by weight of ginkgo, 10-30 parts by weight of Western seaweed, 10-30 parts by weight of seaweed, 10-30 parts by weight of kelp, 10-30 parts by weight of seaweed, 10-30 parts by weight of seaweed, It is desirable to include 10 to 30 parts by weight of pine needles, 1 to 10 parts by weight of beta-carotene, and 1 to 10 parts by weight of vitamins as active ingredients, taking into account the effects of improving overall liver function and preventing and improving hair loss.

Meanwhile, the food composition of the present invention preferably further comprises Rosa davurica stem extract and Quercus parsley extract as active ingredients.

Rosa davurica is a perennial plant belonging to the Rosaceae family. Its stem extract has excellent antioxidant and anti-inflammatory activities and plays a role in alleviating hair loss symptoms by improving blood circulation and liver function.

Among water parsley, wild parsley has many leaves and short stems, and mainly grows wild in springs in valleys, wetlands in fields, or watersides. In the present invention, leaves and stems or their above-ground parts are used. The stone parsley is rich in various amino acids and contains a large amount of minerals such as vitamins, calcium, phosphorus, and potassium, which helps normalize endocrine hormones and has excellent antioxidant and anti-inflammatory activities, improving liver function and alleviating hair loss. do.

In the present invention, the extraction method for the above-mentioned Saengyeolgi Stem Extract and Stone Water parsley extract is sufficient as long as it is extracted using water, ethanol, or a mixed solution thereof as a solvent. Methods for producing extracts from such natural products are sufficiently known in the field to which this technology belongs. Since it is well known, detailed description thereof will be omitted.

It is preferable that the raw yeolgui stem extract and the stone water parsley extract are each included in an amount of 5 to 20 parts by weight based on 100 parts by weight of the chaga mushroom, and this is a mixing ratio that takes into account the improvement of liver function and alopecia.

In addition, the food composition of the present invention preferably further contains Asparagopsis taxiformis extract and Martensia jejuensis extract as active ingredients.

Asparagopsis taxiformis is a species belonging to red algae and is distributed worldwide in tropical and temperate waters. This extract of seaweed not only has excellent antibacterial activity, but is also rich in minerals, which not only promotes blood circulation, but also improves alopecia by supplying sufficient nutrition to the dermal papilla.

In addition, Martensia jejuensis is a domestic endemic species growing in Jeju waters belonging to the red algae order. In addition, it has excellent antibacterial activity like seaweed, and is rich in minerals to promote blood circulation. Improves alopecia by providing sufficient nutrition to the dermal papilla.

In addition, the seaweed extract and manufactured silk net extract also improve liver function.

At this time, the extraction method of the sea buckthorn extract and Jeju silk mesh is sufficient as long as it is extracted using water, ethanol, or a mixed solution thereof as a solvent, and the method of producing extracts from these natural products is sufficiently known in the field to which this technology belongs. Since it is well known, detailed description thereof will be omitted.

The sea buckthorn extract and Jeju silk net extract are preferably included in an amount of 5 to 20 parts by weight, respectively, based on 100 parts by weight of the chaga mushroom, which is a mixing ratio that takes into account the improvement of liver function and alopecia.

In addition, the food composition of the present invention may further include 5 to 20 parts by weight of Ojuk leaf extract as an active ingredient based on 100 parts by weight of the chaga mushroom.

Phyllostachys nigra (Phyllostachys nigra) is a plant from the same Graminae family as rice. Its leaves (Phyllostachys nigra) have excellent antioxidant activity and are effective in treating hair loss due to their excellent blood circulation improvement activity. In addition, the extract of the bamboo leaf suppresses male hormones and provides an even better effect on male pattern hair loss.

Meanwhile, the food composition according to the present invention is a health functional food and can be provided in the form of powder, pills, tablets, etc., and can be provided by adding it as an additive to other general foods, so the form is naturally not limited. do.

In addition, although the present invention only describes the effect of improving liver function and preventing and improving alopecia, it has the effect of helping the consumer maintain his or her health, such as alleviating various stresses and improving chronic fatigue.

The food composition of the present invention can be consumed once a day in an amount of 2 to 3 g after a meal, but this is not limited.

Hereinafter, the present invention will be described in detail through specific examples.

(Example 1)

Add chaga mushroom, thistle (root, stem, and leaf mixed), goldenrod, cypress root, reishi mushroom, mugwort, garlic, ginkgo, wild seaweed, seaweed, kelp, seaweed, seaweed, and pine needle into 2 times the weight of 70% ethanol, Each extract was obtained by extraction at 40°C for 5 hours. The extract was filtered under reduced pressure with filter paper, concentrated under reduced pressure at 40°C, and then freeze-dried to obtain the final extract.

100 parts by weight of the obtained chaga extract, 50 parts by weight of thistle extract, 20 parts by weight of goldenrod extract, 20 parts by weight of Macmundong extract, 70 parts by weight of Reishi mushroom extract, 20 parts by weight of mugwort extract, 20 parts by weight of garlic extract, 20 parts by weight of ginkgo extract. Parts by weight, 20 parts by weight of Western lion extract, 20 parts by weight of seaweed extract, 20 parts by weight of kelp extract, 20 parts by weight of green seaweed extract, 20 parts by weight of seaweed extract, and 20 parts by weight of pine needle extract were mixed, and then 5 parts by weight of beta-carotene, A food composition was prepared by mixing 1 part by weight of vitamin D3, 1 part by weight of vitamin B2, 1 part by weight of vitamin B2, 1 part by weight of vitamin B6 hydrochloride, and 1 part by weight of vitamin C.

(Example 2)

The same procedure as in Example 1 was carried out, but when mixing the above extracts, 10 parts by weight of Saengyeolgi stem extract and 10 parts by weight of Stone water parsley extract were further mixed.

At this time, the extracts were obtained by placing 2 times the weight of the stems of Sagittarius or the above-ground parts of Stone parsley in 70% ethanol and extracting at 40°C for 5 hours. The extracts were filtered under reduced pressure with filter paper and concentrated under reduced pressure at 40°C. After that, it was prepared by freeze-drying.

(Example 3)

The same procedure as in Example 2 was carried out, except that when mixing the above extracts, 10 parts by weight of seaweed extract and 10 parts by weight of Jeju silk net extract were further mixed.

At this time, the extract was obtained by placing 2 times the weight of seaweed or Jeju silk mesh seedlings in 70% ethanol and extracting at 40°C for 5 hours. The extracts were filtered under reduced pressure with filter paper and filtered at 40°C. It was prepared by concentrating under reduced pressure and then freeze-drying.

(Test Example 1)

In order to confirm the effect of improving liver function, Examples 1 to 3 were treated with 300mM alcohol, and then the hepatocellular protective activity was confirmed three times.

More specifically, the medium of the flask in which cells (more than 80%) were cultured was removed, Trypsin was added, and the flask was incubated for 2 minutes. After incubation, the flask was tapped to drop the cells and placed in a 15mL falcon tube. An appropriate amount of medium was added to the tube and centrifuged at 15,000 rpm for 10 minutes. Then, discard all of the supernatant, add an appropriate amount of medium, pipet to loosen the pellet, perform cell counting to adjust the number of cells, add 180 μL of cell dilution to each 96 well plate, and incubate in an incubator at 37°C and 5% CO₂ for 24 hours. Cultured. Afterwards, the sample was diluted with the dissolved solvent as needed, and 20 μL of the diluted sample was placed in a 96-well plate. After culturing for 2 hours in an incubator under 37°C and 5% CO₂ conditions, 300mM of 95% EtOH was added and cultured for 48 hours. .

Then, add 20 μL of MTT reagent, incubate for 4 hours in an incubator under 37°C and 5% CO₂ conditions, invert and shake off the MTT reagent, add 200 μL of DMSO-Ethanol (1:1), incubate for 10 minutes, and incubate at 570-630 nm. The absorbance was measured. The results are shown in Table 1 below as the average value of three times for each sample.

Test Example 1 Results division Jeongsang-gun control group
(300mM EtOH treatment) Example 1
(400ug/mL) Example 2
(400ug/mL) Example 3
(400ug/mL) absorbance 0.576 0.709 0.736 0.741 0.823 Jeongsang-gun
Contrast active (%) 100 93.742 97.268 98.267 108.814

As shown in Table 1, it was confirmed that Examples 1 to 3 of the present invention had superior hepatocellular protective activity compared to the control group. In addition, the activity of Example 3 was superior to that of the normal group.

(Test Example 2)

Human dermal papilla cells were cultured at 37°C and 5% CO ₂ using DMEM medium supplemented with 10% FBS. Cells were distributed at 1×10 ⁵ cells/mL per well of 96 wells and cultured for 24 hours. After 24 hours, the medium used in the previous culture was removed, the sample was dissolved in DMSO, and then diluted with the medium so that the final concentration of DMSO was 1%, and the samples were treated for each concentration at 37°C and 5% CO ₂ for 24 hours. did. As a positive control group, finasteride was treated at 0.5ppm. After treatment, 20㎕ of 0.2% MTT solution was added to each well and reacted for 3 hours in an incubator at 37°C and 5% CO ₂ . After the reaction, all supernatants were removed, 150 μl of DMSO was added each, and all formazan produced was dissolved at room temperature for 10 minutes, and the change in absorbance was measured at 570 nm using an ELISA reader. Cell growth rate (%) is shown in Figure 1 using the following equation.

Cell growth rate (%) = (absorbance of sample treatment group/absorbance of control group) × 100

As shown in Figure 1, it was confirmed that Examples 1 to 3 of the present invention all had excellent growth and proliferation effects of dermal papilla cells in a concentration-dependent manner.

(Test Example 3)

The subjects were 24 adult men and women between the ages of 33 and 55 who were thought to have alopecia. They were divided into groups of 6, and each group was administered Examples 1 to 3 and Comparative Example 1 (commercially available vitamins) once a day. It was to be taken 2g after each meal for 4 weeks. And the effect was judged after 4 weeks.

The judgment of effectiveness was evaluated in 5 stages using visual evaluation, number of hair loss, and the subject's personal opinion as evaluation scales, and the score was given out of 5 in increments of 1 point. The results are shown in Table 2 below as the average score.

Test Example 3 Results judgment score Example 1 Example 2 Example 3 Comparative Example 1 Visual evaluation 3.4 3.5 3.8 2.0 Personal opinion 3.6 3.7 3.9 2.1 hair loss water 3.5 3.7 3.9 2.1 Comprehensive improvement 3.5 3.7 3.8 2.1 1: worsening
2: No change
3: Slight improvement
4: Moderate improvement
5: Much improved

As shown in Table 2, it was confirmed that all groups that consumed Examples 1 to 3 of the present invention had an improvement effect in visual evaluation, personal opinion, and number of hair loss.

As the specific parts of the present invention have been described in detail above, it is clear to those skilled in the art that these specific techniques are merely preferred embodiments and do not limit the scope of the present invention. Accordingly, the substantial scope of the present invention will be defined by the appended claims and their equivalents.

Claims (4)

Improving liver function and resting phase, characterized by containing chaga mushroom, thistle, goldenrod, maekmundong, reishi mushroom, mugwort, garlic, ginkgo, western mountain lion, seaweed, kelp, sea lettuce, seaweed, pine needle, beta-carotene and vitamins as active ingredients. Or a food composition for preventing and improving hair loss during the growth period.
According to paragraph 1,
The vitamins include one or more of vitamin D3, vitamin B2, vitamin B3, vitamin B6 hydrochloride, and vitamin C,
For 100 parts by weight of the above chaga mushrooms, 30-70 parts by weight of thistle, 10-30 parts by weight of gold, 10-30 parts by weight of Macmundong, 50-100 parts by weight of reishi mushroom, 10-30 parts by weight of mugwort, 10-30 parts by weight of garlic. 10-30 parts by weight, ginkgo 10-30 parts by weight, 10-30 parts by weight of western mountain lion, 10-30 parts by weight of seaweed, 10-30 parts by weight of kelp, 10-30 parts by weight of green seaweed, 10-30 parts by weight, 10-30 parts by weight of pine needles. A food composition for improving liver function and preventing and improving telogen or anagen hair loss, comprising 1 to 10 parts by weight of beta-carotene and 1 to 10 parts by weight of vitamins as active ingredients.
According to paragraph 1,
A food composition for improving liver function and preventing and improving hair loss in the telogen or anagen phase, further comprising Rosa davurica stem extract and Stone water parsley extract as active ingredients.
According to claim 1 or 3,
A food composition for improving liver function and preventing and improving telogen or anagen hair loss, further comprising Asparagopsis taxiformis extract and Martensia jejuensis extract as active ingredients.