KR20230153529A - 다양한 면역세포를 위한 단일사슬 및 다중사슬 합성 항원 수용체 - Google Patents

다양한 면역세포를 위한 단일사슬 및 다중사슬 합성 항원 수용체 Download PDF

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KR20230153529A
KR20230153529A KR1020237031803A KR20237031803A KR20230153529A KR 20230153529 A KR20230153529 A KR 20230153529A KR 1020237031803 A KR1020237031803 A KR 1020237031803A KR 20237031803 A KR20237031803 A KR 20237031803A KR 20230153529 A KR20230153529 A KR 20230153529A
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cell
receptor
antigen
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프리트 엠. 쇼드하리
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프리트 엠. 쇼드하리
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    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
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    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K40/15—Natural-killer [NK] cells; Natural-killer T [NKT] cells
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    • A61K40/20—Cellular immunotherapy characterised by the effect or the function of the cells
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    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • C07K16/2878—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
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    • C12N5/06—Animal cells or tissues; Human cells or tissues
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    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
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    • A—HUMAN NECESSITIES
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    • A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
    • A61K2039/572—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 cytotoxic response
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    • A61K2239/31—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterized by the route of administration
    • A—HUMAN NECESSITIES
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    • A61K2239/38—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the dose, timing or administration schedule
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the cancer treated
    • A61K2239/48—Blood cells, e.g. leukemia or lymphoma
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    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
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    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
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    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
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    • C12N2740/16041—Use of virus, viral particle or viral elements as a vector
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  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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KR1020237031803A 2021-02-19 2022-02-21 다양한 면역세포를 위한 단일사슬 및 다중사슬 합성 항원 수용체 Pending KR20230153529A (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US202163151421P 2021-02-19 2021-02-19
US63/151,421 2021-02-19
US202163245181P 2021-09-16 2021-09-16
US63/245,181 2021-09-16
PCT/US2022/017177 WO2022178367A2 (en) 2021-02-19 2022-02-21 Single-chain and multi-chain synthetic antigen receptors for diverse immune cells

Publications (1)

Publication Number Publication Date
KR20230153529A true KR20230153529A (ko) 2023-11-06

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KR1020237031803A Pending KR20230153529A (ko) 2021-02-19 2022-02-21 다양한 면역세포를 위한 단일사슬 및 다중사슬 합성 항원 수용체

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Country Link
US (1) US20240390496A1 (https=)
EP (1) EP4297769A4 (https=)
JP (1) JP2024518011A (https=)
KR (1) KR20230153529A (https=)
AU (1) AU2022224066A1 (https=)
CA (1) CA3208717A1 (https=)
IL (1) IL305175A (https=)
WO (1) WO2022178367A2 (https=)

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