KR20230147131A - Hiv 인테그라제 억제제로서 유용한 테트라시클릭 헤테로사이클 화합물 - Google Patents
Hiv 인테그라제 억제제로서 유용한 테트라시클릭 헤테로사이클 화합물 Download PDFInfo
- Publication number
- KR20230147131A KR20230147131A KR1020237031339A KR20237031339A KR20230147131A KR 20230147131 A KR20230147131 A KR 20230147131A KR 1020237031339 A KR1020237031339 A KR 1020237031339A KR 20237031339 A KR20237031339 A KR 20237031339A KR 20230147131 A KR20230147131 A KR 20230147131A
- Authority
- KR
- South Korea
- Prior art keywords
- hiv
- pharmaceutically acceptable
- compound
- acceptable salt
- subject
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Virology (AREA)
- Epidemiology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Molecular Biology (AREA)
- AIDS & HIV (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202163149927P | 2021-02-16 | 2021-02-16 | |
| US63/149,927 | 2021-02-16 | ||
| PCT/US2022/016261 WO2022177840A1 (en) | 2021-02-16 | 2022-02-14 | Tetracyclic heterocycle compounds useful as hiv integrase inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20230147131A true KR20230147131A (ko) | 2023-10-20 |
Family
ID=80625127
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020237031339A Pending KR20230147131A (ko) | 2021-02-16 | 2022-02-14 | Hiv 인테그라제 억제제로서 유용한 테트라시클릭 헤테로사이클 화합물 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US11958864B2 (https=) |
| EP (1) | EP4294813B1 (https=) |
| JP (1) | JP2024507788A (https=) |
| KR (1) | KR20230147131A (https=) |
| CN (1) | CN117083282A (https=) |
| AR (1) | AR124868A1 (https=) |
| CA (1) | CA3208396A1 (https=) |
| ES (1) | ES3048138T3 (https=) |
| MX (1) | MX2023009445A (https=) |
| TW (1) | TW202246286A (https=) |
| WO (1) | WO2022177840A1 (https=) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MY201239A (en) | 2019-03-22 | 2024-02-13 | Gilead Sciences Inc | Bridged tricyclic carbamoylpyridone compounds and their pharmaceutical use |
| PE20221569A1 (es) | 2020-02-24 | 2022-10-06 | Gilead Sciences Inc | Compuestos tetraciclicos para el tratamiento de infecciones por vih |
| ES3064867T3 (en) | 2020-09-30 | 2026-04-29 | Gilead Sciences Inc | Bridged tricyclic carbamoylpyridone compounds for a use in the treatment of hiv |
| US11613546B2 (en) | 2021-01-19 | 2023-03-28 | Gilead Sciences, Inc. | Substituted pyridotriazine compounds and uses thereof |
| TW202446773A (zh) | 2022-04-06 | 2024-12-01 | 美商基利科學股份有限公司 | 橋聯三環胺甲醯基吡啶酮化合物及其用途 |
| EP4704976A1 (en) * | 2023-04-28 | 2026-03-11 | Merck Sharp & Dohme LLC | Delivery devices for anti-hiv compounds |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010011814A1 (en) * | 2008-07-25 | 2010-01-28 | Smithkline Beecham Corporation | Chemical compounds |
| JP5551697B2 (ja) * | 2008-07-25 | 2014-07-16 | ビーブ・ヘルスケア・カンパニー | 化合物 |
| ES2448766T3 (es) * | 2008-07-25 | 2014-03-17 | Viiv Healthcare Company | Profármacos de dolutegravir |
| DK2620436T3 (en) * | 2010-09-24 | 2018-07-30 | Shionogi & Co | Substituted polycyclic carbamoylpyridone derivative prodrug |
| WO2017113288A1 (en) * | 2015-12-31 | 2017-07-06 | Merck Sharp & Dohme Corp. | Fused tricyclic heterocyclic compounds as hiv integrase inhibitors |
| JOP20190130A1 (ar) * | 2016-12-02 | 2019-06-02 | Merck Sharp & Dohme | مركبات حلقية غير متجانسة رباعية الحلقات مفيدة كمثبطات إنزيم مدمج لفيروس نقص المناعة البشرية (hiv) |
| EP3573984A4 (en) * | 2017-01-26 | 2020-07-29 | Merck Sharp & Dohme Corp. | USEFUL SUBSTITUTE QUINOLIZINE DERIVATIVES AS HIV INTEGRASE INHIBITORS |
-
2022
- 2022-02-14 MX MX2023009445A patent/MX2023009445A/es unknown
- 2022-02-14 ES ES22707560T patent/ES3048138T3/es active Active
- 2022-02-14 US US17/670,689 patent/US11958864B2/en active Active
- 2022-02-14 EP EP22707560.3A patent/EP4294813B1/en active Active
- 2022-02-14 CN CN202280022034.3A patent/CN117083282A/zh active Pending
- 2022-02-14 TW TW111105302A patent/TW202246286A/zh unknown
- 2022-02-14 WO PCT/US2022/016261 patent/WO2022177840A1/en not_active Ceased
- 2022-02-14 CA CA3208396A patent/CA3208396A1/en active Pending
- 2022-02-14 JP JP2023548941A patent/JP2024507788A/ja active Pending
- 2022-02-14 KR KR1020237031339A patent/KR20230147131A/ko active Pending
- 2022-02-14 AR ARP220100289A patent/AR124868A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU2022223241A1 (en) | 2023-08-24 |
| EP4294813A1 (en) | 2023-12-27 |
| AR124868A1 (es) | 2023-05-10 |
| US20220259227A1 (en) | 2022-08-18 |
| MX2023009445A (es) | 2023-08-25 |
| US11958864B2 (en) | 2024-04-16 |
| TW202246286A (zh) | 2022-12-01 |
| WO2022177840A1 (en) | 2022-08-25 |
| JP2024507788A (ja) | 2024-02-21 |
| ES3048138T3 (en) | 2025-12-09 |
| EP4294813B1 (en) | 2025-09-10 |
| CA3208396A1 (en) | 2022-08-25 |
| CN117083282A (zh) | 2023-11-17 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PA0105 | International application |
Patent event date: 20230913 Patent event code: PA01051R01D Comment text: International Patent Application |
|
| PG1501 | Laying open of application | ||
| A201 | Request for examination | ||
| PA0201 | Request for examination |
Patent event code: PA02012R01D Patent event date: 20250212 Comment text: Request for Examination of Application |