KR20230131481A - Hiv 백신 및 이의 사용 방법 - Google Patents

Hiv 백신 및 이의 사용 방법 Download PDF

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KR20230131481A
KR20230131481A KR1020237027110A KR20237027110A KR20230131481A KR 20230131481 A KR20230131481 A KR 20230131481A KR 1020237027110 A KR1020237027110 A KR 1020237027110A KR 20237027110 A KR20237027110 A KR 20237027110A KR 20230131481 A KR20230131481 A KR 20230131481A
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seq
fusion polypeptides
nos
fusion
polynucleotides
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지아니 리
시난 리우
아주르 티. 마카드장게
스티븐 알. 마틴
사라 슈미트
헤샴 셰하타
펠릭스 스테메세더
에브구에니아 스바로브스카이아
아르차나 브이. 부파티
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길리애드 사이언시즈, 인코포레이티드
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KR1020237027110A 2021-01-14 2022-01-12 Hiv 백신 및 이의 사용 방법 Pending KR20230131481A (ko)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US202163137521P 2021-01-14 2021-01-14
US63/137,521 2021-01-14
US202163149820P 2021-02-16 2021-02-16
US63/149,820 2021-02-16
US202163170900P 2021-04-05 2021-04-05
US63/170,900 2021-04-05
PCT/US2022/012195 WO2022155258A1 (en) 2021-01-14 2022-01-12 Hiv vaccines and methods of using

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KR20230131481A true KR20230131481A (ko) 2023-09-13

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US (3) US12053517B2 (https=)
EP (1) EP4277652A1 (https=)
JP (3) JP7693813B2 (https=)
KR (1) KR20230131481A (https=)
AU (1) AU2022207422B2 (https=)
CA (1) CA3202466A1 (https=)
CL (1) CL2023002042A1 (https=)
CO (1) CO2023009285A2 (https=)
CR (1) CR20230312A (https=)
DO (1) DOP2023000137A (https=)
IL (1) IL304131A (https=)
MX (1) MX2023008272A (https=)
PE (1) PE20241071A1 (https=)
PH (1) PH12023500016A1 (https=)
WO (1) WO2022155258A1 (https=)

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Publication number Priority date Publication date Assignee Title
CN112980878B (zh) * 2021-02-04 2023-03-31 中国农业科学院兰州兽医研究所 Hdac8基因敲除的bhk-21细胞系及其构建方法和应用
CN112877275B (zh) * 2021-02-04 2023-03-31 中国农业科学院兰州兽医研究所 Hdac2基因敲除的bhk-21细胞系及其构建方法和应用
AU2023330037A1 (en) 2022-08-26 2025-03-06 Gilead Sciences, Inc. Dosing and scheduling regimen for broadly neutralizing antibodies
US20240226130A1 (en) 2022-10-04 2024-07-11 Gilead Sciences, Inc. 4'-thionucleoside analogues and their pharmaceutical use
AU2024343172A1 (en) 2023-09-15 2026-03-05 Gilead Sciences, Inc. Arenavirus formulations, methods and uses thereof
US20250333424A1 (en) 2024-03-01 2025-10-30 Gilead Sciences, Inc. Antiviral compounds

Family Cites Families (72)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6858712B1 (en) 1984-08-22 2005-02-22 The United States Of America As Represented By The Department Of Health And Human Services Cloning and expression of HTLV-III DNA
US6174666B1 (en) 1992-03-27 2001-01-16 The United States Of America As Represented By The Department Of Health And Human Services Method of eliminating inhibitory/instability regions from mRNA
WO1996004386A1 (en) 1994-08-05 1996-02-15 Warner-Lambert Company Method of using transdominant negative retroviral integrase in the treatment of retroviral infection
US7488485B2 (en) 2003-09-16 2009-02-10 University Of Kansas Medical Center DNA vaccine compositions and methods of use
DE19856463B4 (de) 1998-11-26 2006-02-02 Heinrich-Pette-Institut Retrovirale, mit LCMV pseudotypisierte Hybrid-Vektoren
US7935805B1 (en) 1998-12-31 2011-05-03 Novartis Vaccines & Diagnostics, Inc Polynucleotides encoding antigenic HIV Type C polypeptides, polypeptides and uses thereof
AU2487300A (en) 1998-12-31 2000-07-31 Chiron Corporation Polynucleotides encoding antigenic hiv type c polypeptides, polypeptides and uses thereof
AUPQ776100A0 (en) 2000-05-26 2000-06-15 Australian National University, The Synthetic molecules and uses therefor
CA2458995C (en) 2001-08-31 2013-04-30 Chiron Corporation Polynucleotides encoding antigenic hiv type b polypeptides, polypeptides and uses thereof
US20070077257A1 (en) 2001-09-14 2007-04-05 Emini Emilio A Enhanced first generation adenovirus vaccines expressing condon optimized HIV1-Gag, Pol, Nef and modifications
US7195768B2 (en) 2001-11-07 2007-03-27 Duke University Polyvalent immunogen
WO2003039470A2 (en) 2001-11-07 2003-05-15 Duke University Polyvalent immunogen of hiv
US7172761B2 (en) 2001-11-07 2007-02-06 Duke University Polyvalent immunogen
EP1456376A4 (en) 2001-11-16 2006-09-06 Us Gov Health & Human Serv NEW CHIMERAL REV, TAT AND NEF ANTIGENES
GB0225788D0 (en) 2002-11-05 2002-12-11 Glaxo Group Ltd Vaccine
ATE520708T1 (de) 2003-03-28 2011-09-15 Us Gov Health & Human Serv Immunogenetische hiv-1 multi-klade, multivalente konstrukte und deren verwendung
BRPI0414443A (pt) 2003-09-17 2006-11-21 Univ Duke imunógenos consensuais/ancestrais
WO2005028634A2 (en) 2003-09-18 2005-03-31 Emory University Improved mva vaccines
GB2406336A (en) 2003-09-24 2005-03-30 Oxxon Pharmaccines Ltd HIV Pharmaccines
AU2004276559A1 (en) 2003-09-24 2005-04-07 Oxxon Therapeutics Limited HIV pharmaccines
GB0417494D0 (en) 2004-08-05 2004-09-08 Glaxosmithkline Biolog Sa Vaccine
BRPI0514447B8 (pt) 2004-08-17 2021-05-25 Centre Nat Rech Scient uso da função imunosupressora de uma proteína acessória do vírus da imunodeficiência humana ou do símio para a preparação de uma vacina
US8000900B2 (en) 2004-09-21 2011-08-16 Microsoft Corporation Association-based predictions of pathogen characteristics
US8478535B2 (en) 2004-10-29 2013-07-02 Microsoft Corporation Systems and methods that utilize machine learning algorithms to facilitate assembly of aids vaccine cocktails
EP1856143A2 (en) 2005-02-24 2007-11-21 Medical Research Council Hivcon: anhiv immunogen and uses thereof
ES2281252B1 (es) 2005-07-27 2009-02-16 Consejo Superior De Investigaciones Cientificas Vectores recombinantes basados en el virus modificado de ankara (mva) como vacunas preventivas y terapeuticas contra el sida.
CN101969996A (zh) 2005-08-23 2011-02-09 加利福尼亚大学董事会 多价疫苗
US7951377B2 (en) 2005-08-23 2011-05-31 Los Alamos National Security, Llc Mosaic clade M human immunodeficiency virus type 1 (HIV-1) envelope immunogens
DK2029168T3 (da) 2006-06-02 2013-01-14 Int Aids Vaccine Initiative HIV-1 Clade A konsensussekvenser, antigener og transgener.
CA3057039C (en) 2006-07-28 2023-02-28 The Trustees Of The University Of Pennsylvania Hiv consensus envelope sequences and methods for using same
US8452541B2 (en) 2007-06-18 2013-05-28 Microsoft Corporation Vaccine design methodology
US8452542B2 (en) 2007-08-07 2013-05-28 Lawrence Livermore National Security, Llc. Structure-sequence based analysis for identification of conserved regions in proteins
SI2604695T1 (sl) 2007-12-27 2023-03-31 Universitaet Zuerich Prorektorat Forschung Replikacijsko defektni arenavirusni vektorji
NZ602504A (en) 2008-11-18 2014-01-31 Beth Israel Hospital Antiviral vaccines with improved cellular immunogenicity
WO2011019932A2 (en) 2009-08-14 2011-02-17 Theraclone Sciences, Inc. Compositions and methods for the therapy and diagnosis of influenza
MX2012011189A (es) 2010-03-26 2013-02-07 Glaxosmithkline Biolog Sa Vacuna contra el virus e inmunodeficiencia humana.
CA2833425C (en) 2011-04-07 2018-08-21 Her Majesty The Queen In Right Of Canada As Represented By The Minister Of Health Protease cleavage site peptides as an hiv vaccine
GB201122297D0 (en) 2011-12-23 2012-02-01 Retroscreen Virology Ltd Vaccine - screening method
EP2620446A1 (en) 2012-01-27 2013-07-31 Laboratorios Del Dr. Esteve, S.A. Immunogens for HIV vaccination
US9501614B2 (en) 2012-05-22 2016-11-22 Indiana University Research And Technology Corporation Method for computer-aided vaccine discovery
WO2013188886A2 (en) 2012-06-15 2013-12-19 California Institute Of Technology Method and system for parallel batch processing of data sets using gaussian process with batch upper confidence bound
WO2014026033A1 (en) 2012-08-08 2014-02-13 University Of Florida Research Foundation, Inc. Cross-reactive t cell epitopes of hiv, siv, and fiv for vaccines in humans and cats
WO2014036488A1 (en) 2012-08-31 2014-03-06 Biovest International, Inc. Methods for producing high-fidelity autologous idiotype vaccines
CA2884859C (en) 2012-09-12 2024-06-18 Duke University Hiv-1 antibody evolution immunogens
TWI626948B (zh) 2013-03-26 2018-06-21 環球免疫公司 治療或預防人類免疫缺乏病毒感染之組合物及方法
US9732121B2 (en) 2013-09-25 2017-08-15 The Board Of Trustees Of The Leland Stanford Junior University Rational vaccine design for hepatitis C virus
ES2957209T3 (es) * 2013-09-30 2024-01-15 Triad Nat Security Llc Polipéptidos inmunogénicos mosaicos del VIH de región conservada
WO2015048796A2 (en) 2013-09-30 2015-04-02 Los Alamos National Security, Llc Mosaic hiv envelope immunogenic polypeptides
CN106999571B (zh) 2014-09-26 2020-10-02 贝斯以色列护理医疗中心有限公司 诱导针对人免疫缺陷病毒感染的保护性免疫性的方法和组合物
MA40783A (fr) 2014-10-03 2017-08-08 Los Alamos Nat Security Llc Vaccins contre le vih comprenant un ou plusieurs antigènes episensus de population
SI3218504T1 (sl) 2014-11-13 2020-11-30 Universite De Geneve Tri-segmentirani arenavirusi kot vakcinski vektorji
US10421788B2 (en) 2015-09-10 2019-09-24 The General Hospital Corporation Synthesizing vaccines, immunogens, and antibodies
CA2997955A1 (en) 2015-09-15 2017-03-23 Gilead Sciences, Inc. Modulators of toll-like receptors for the treatment of hiv
ES2970865T3 (es) 2015-12-16 2024-05-31 Gritstone Bio Inc Identificación, fabricación y uso de neoantígenos
IL262963B2 (en) 2016-05-18 2025-01-01 Hookipa Biotech Gmbh Trisegmented PICHINDE viruses as vaccine vectors
WO2018075559A1 (en) 2016-10-17 2018-04-26 Beth Israel Deaconess Medical Center, Inc. Signature-based human immunodeficiency virus (hiv) envelope (env) trimer vaccines and methods of using the same
JP2020500552A (ja) 2016-11-23 2020-01-16 グリットストーン オンコロジー インコーポレイテッド 新生抗原のウイルスによる送達方法
KR20260047644A (ko) 2017-03-30 2026-04-08 더 유니버서티 어브 퀸슬랜드 키메라 분자 및 그의 용도
CA3060569A1 (en) 2017-04-19 2018-10-25 Gritstone Oncology, Inc. Neoantigen identification, manufacture, and use
EP3634449A4 (en) 2017-05-08 2021-03-17 Gritstone Oncology, Inc. ALPHAVIRUS NEOANTIGEN VECTORS
AU2018279627B2 (en) 2017-06-09 2023-08-10 Seattle Project Corp. Neoantigen identification, manufacture, and use
US20210147550A1 (en) 2017-08-18 2021-05-20 Joshua Michael Francis Antigen-binding proteins targeting shared antigens
US20200363414A1 (en) 2017-09-05 2020-11-19 Gritstone Oncology, Inc. Neoantigen Identification for T-Cell Therapy
WO2019070730A1 (en) 2017-10-02 2019-04-11 Duke University MOSAIC ENVELOPES OF HIV-1 TO INDUCE ADCC RESPONSES
EP4576103A3 (en) 2017-10-10 2025-08-27 Gritstone bio, Inc. Neoantigen identification using hotspots
CN111630602A (zh) 2017-11-22 2020-09-04 磨石肿瘤生物技术公司 减少新抗原的接合表位呈递
EP3731876A4 (en) 2017-12-28 2022-04-06 Gritstone bio, Inc. ANTIGEN-BINDING PROTEINS TARGETING SHARED ANTIGENS
KR20220041844A (ko) 2019-07-02 2022-04-01 그릿스톤 바이오, 인코포레이티드 Hiv 항원 및 mhc 복합체
KR20240137107A (ko) 2019-07-16 2024-09-19 길리애드 사이언시즈, 인코포레이티드 Hiv 백신, 및 이의 제조 및 사용 방법
US12559527B2 (en) 2019-10-23 2026-02-24 Duke University Compositions comprising V2 opt HIV envelopes
WO2022006095A2 (en) 2020-06-29 2022-01-06 Duke University Mosaic hiv-1 envelopes to induce adcc responses
WO2023064424A2 (en) 2021-10-12 2023-04-20 Duke University Compositions comprising v2 opt hiv envelopes

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