KR20230131205A - 병용 요법 - Google Patents

Info

Publication number

KR20230131205A

KR20230131205A KR1020237023345A KR20237023345A KR20230131205A KR 20230131205 A KR20230131205 A KR 20230131205A KR 1020237023345 A KR1020237023345 A KR 1020237023345A KR 20237023345 A KR20237023345 A KR 20237023345A KR 20230131205 A KR20230131205 A KR 20230131205A

Authority

KR

South Korea

Prior art keywords

antibody

domain

seq

binding site

radio

Prior art date

2021-01-13

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
• Global Dossier
• Discuss

• 238000002648 combination therapy Methods 0.000 title abstract description 24
• 238000011363 radioimmunotherapy Methods 0.000 claims abstract description 33
• 230000027455 binding Effects 0.000 claims description 523
• 239000000427 antigen Substances 0.000 claims description 492
• 108091007433 antigens Proteins 0.000 claims description 490
• 102000036639 antigens Human genes 0.000 claims description 490
• 150000001875 compounds Chemical class 0.000 claims description 229
• 206010028980 Neoplasm Diseases 0.000 claims description 161
• 241000282414 Homo sapiens Species 0.000 claims description 103
• 238000000034 method Methods 0.000 claims description 102
• 238000011282 treatment Methods 0.000 claims description 70
• 238000009169 immunotherapy Methods 0.000 claims description 60
• 229940076838 Immune checkpoint inhibitor Drugs 0.000 claims description 55
• 239000012274 immune-checkpoint protein inhibitor Substances 0.000 claims description 55
• 102000037984 Inhibitory immune checkpoint proteins Human genes 0.000 claims description 51
• 108091008026 Inhibitory immune checkpoint proteins Proteins 0.000 claims description 51
• FQIHLPGWBOBPSG-UHFFFAOYSA-N 2-[4,7,10-tris(2-amino-2-oxoethyl)-1,4,7,10-tetrazacyclododec-1-yl]acetamide Chemical compound NC(=O)CN1CCN(CC(N)=O)CCN(CC(N)=O)CCN(CC(N)=O)CC1 FQIHLPGWBOBPSG-UHFFFAOYSA-N 0.000 claims description 45
• 201000011510 cancer Diseases 0.000 claims description 42
• 229940123189 CD40 agonist Drugs 0.000 claims description 31
• 239000012636 effector Substances 0.000 claims description 25
• 102100024216 Programmed cell death 1 ligand 1 Human genes 0.000 claims description 22
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 22
• 230000006870 function Effects 0.000 claims description 21
• 239000000203 mixture Substances 0.000 claims description 21
• 102100040245 Tumor necrosis factor receptor superfamily member 5 Human genes 0.000 claims description 18
• 230000004614 tumor growth Effects 0.000 claims description 17
• 230000002062 proliferating effect Effects 0.000 claims description 16
• 101001117317 Homo sapiens Programmed cell death 1 ligand 1 Proteins 0.000 claims description 15
• 230000001965 increasing effect Effects 0.000 claims description 15
• 201000010099 disease Diseases 0.000 claims description 14
• 101150013553 CD40 gene Proteins 0.000 claims description 13
• 239000004480 active ingredient Substances 0.000 claims description 12
• 102100039498 Cytotoxic T-lymphocyte protein 4 Human genes 0.000 claims description 10
• 101000889276 Homo sapiens Cytotoxic T-lymphocyte protein 4 Proteins 0.000 claims description 10
• 210000001744 T-lymphocyte Anatomy 0.000 claims description 10
• 239000000556 agonist Substances 0.000 claims description 9
• 239000000825 pharmaceutical preparation Substances 0.000 claims description 8
• 230000004044 response Effects 0.000 claims description 8
• 101000611936 Homo sapiens Programmed cell death protein 1 Proteins 0.000 claims description 7
• 210000001165 lymph node Anatomy 0.000 claims description 7
• 210000000952 spleen Anatomy 0.000 claims description 7
• 230000004083 survival effect Effects 0.000 claims description 7
• 101000834898 Homo sapiens Alpha-synuclein Proteins 0.000 claims description 6
• 101000652359 Homo sapiens Spermatogenesis-associated protein 2 Proteins 0.000 claims description 6
• 102100040678 Programmed cell death protein 1 Human genes 0.000 claims description 6
• 239000003112 inhibitor Substances 0.000 claims description 6
• 229940127557 pharmaceutical product Drugs 0.000 claims description 5
• 230000001270 agonistic effect Effects 0.000 claims description 4
• 230000006054 immunological memory Effects 0.000 claims description 4
• 239000012271 PD-L1 inhibitor Substances 0.000 claims description 3
• 230000004913 activation Effects 0.000 claims description 3
• 230000002601 intratumoral effect Effects 0.000 claims description 3
• 229940121656 pd-l1 inhibitor Drugs 0.000 claims description 3
• 102100026882 Alpha-synuclein Human genes 0.000 claims 1
• 125000003275 alpha amino acid group Chemical group 0.000 description 243
• 108090000765 processed proteins & peptides Proteins 0.000 description 233
• 102100025475 Carcinoembryonic antigen-related cell adhesion molecule 5 Human genes 0.000 description 175
• 108010022366 Carcinoembryonic Antigen Proteins 0.000 description 173
• 229920001184 polypeptide Polymers 0.000 description 170
• 102000004196 processed proteins & peptides Human genes 0.000 description 170
• 108010047041 Complementarity Determining Regions Proteins 0.000 description 108
• 238000006467 substitution reaction Methods 0.000 description 98
• 239000012634 fragment Substances 0.000 description 97
• 108010054477 Immunoglobulin Fab Fragments Proteins 0.000 description 84
• 102000001706 Immunoglobulin Fab Fragments Human genes 0.000 description 84
• 210000004027 cell Anatomy 0.000 description 83
• 125000005647 linker group Chemical group 0.000 description 83
• 235000001014 amino acid Nutrition 0.000 description 70
• 125000000217 alkyl group Chemical group 0.000 description 69
• 229940024606 amino acid Drugs 0.000 description 57
• 150000001413 amino acids Chemical class 0.000 description 55
• 241000699670 Mus sp. Species 0.000 description 43
• 210000004899 c-terminal region Anatomy 0.000 description 38
• 108090000623 proteins and genes Proteins 0.000 description 38
• 238000007920 subcutaneous administration Methods 0.000 description 36
• 239000003795 chemical substances by application Substances 0.000 description 35
• 238000003780 insertion Methods 0.000 description 35
• 230000037431 insertion Effects 0.000 description 35
• 238000012217 deletion Methods 0.000 description 33
• 230000037430 deletion Effects 0.000 description 33
• 125000003295 alanine group Chemical group N[C@@H](C)C(=O)* 0.000 description 32
• 235000018102 proteins Nutrition 0.000 description 29
• 102000004169 proteins and genes Human genes 0.000 description 29
• 239000007924 injection Substances 0.000 description 28
• 238000002347 injection Methods 0.000 description 28
• 150000007523 nucleic acids Chemical class 0.000 description 28
• 108060003951 Immunoglobulin Proteins 0.000 description 27
• 102000018358 immunoglobulin Human genes 0.000 description 27
• 102000039446 nucleic acids Human genes 0.000 description 27
• 108020004707 nucleic acids Proteins 0.000 description 27
• 102000008394 Immunoglobulin Fragments Human genes 0.000 description 24
• 108010021625 Immunoglobulin Fragments Proteins 0.000 description 24
• 230000035772 mutation Effects 0.000 description 22
• 150000002482 oligosaccharides Chemical class 0.000 description 22
• -1 cytosine (C) Chemical compound 0.000 description 21
• 230000004048 modification Effects 0.000 description 21
• 238000012986 modification Methods 0.000 description 21
• 239000013522 chelant Substances 0.000 description 20
• 229920001542 oligosaccharide Polymers 0.000 description 19
• DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 18
• 125000000539 amino acid group Chemical group 0.000 description 18
• 239000002738 chelating agent Substances 0.000 description 18
• 230000014509 gene expression Effects 0.000 description 18
• 230000004481 post-translational protein modification Effects 0.000 description 18
• 238000011579 SCID mouse model Methods 0.000 description 16
• 230000000694 effects Effects 0.000 description 16
• 229910052751 metal Inorganic materials 0.000 description 16
• 239000002184 metal Substances 0.000 description 16
• 230000002285 radioactive effect Effects 0.000 description 16
• 108091007491 NSP3 Papain-like protease domains Proteins 0.000 description 15
• 238000003556 assay Methods 0.000 description 15
• 238000010494 dissociation reaction Methods 0.000 description 15
• 230000005593 dissociations Effects 0.000 description 15
• 230000002829 reductive effect Effects 0.000 description 14
• MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 description 13
• 125000002947 alkylene group Chemical group 0.000 description 13
• 230000010056 antibody-dependent cellular cytotoxicity Effects 0.000 description 13
• 238000013461 design Methods 0.000 description 13
• LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 13
• 239000002953 phosphate buffered saline Substances 0.000 description 13
• 239000013598 vector Substances 0.000 description 13
• 230000004540 complement-dependent cytotoxicity Effects 0.000 description 12
• 238000009826 distribution Methods 0.000 description 12
• 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 12
• 210000001519 tissue Anatomy 0.000 description 12
• 125000001072 heteroaryl group Chemical group 0.000 description 11
• 125000000882 C2-C6 alkenyl group Chemical group 0.000 description 10
• 125000003601 C2-C6 alkynyl group Chemical group 0.000 description 10
• 125000003282 alkyl amino group Chemical group 0.000 description 10
• 230000004071 biological effect Effects 0.000 description 10
• 230000000875 corresponding effect Effects 0.000 description 10
• 125000000592 heterocycloalkyl group Chemical group 0.000 description 10
• 238000001727 in vivo Methods 0.000 description 10
• 230000008685 targeting Effects 0.000 description 10
• 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 description 9
• NFGXHKASABOEEW-UHFFFAOYSA-N 1-methylethyl 11-methoxy-3,7,11-trimethyl-2,4-dodecadienoate Chemical compound COC(C)(C)CCCC(C)CC=CC(C)=CC(=O)OC(C)C NFGXHKASABOEEW-UHFFFAOYSA-N 0.000 description 9
• 101710098119 Chaperonin GroEL 2 Proteins 0.000 description 9
• VCUFZILGIRCDQQ-KRWDZBQOSA-N N-[[(5S)-2-oxo-3-(2-oxo-3H-1,3-benzoxazol-6-yl)-1,3-oxazolidin-5-yl]methyl]-2-[[3-(trifluoromethoxy)phenyl]methylamino]pyrimidine-5-carboxamide Chemical compound O=C1O[C@H](CN1C1=CC2=C(NC(O2)=O)C=C1)CNC(=O)C=1C=NC(=NC=1)NCC1=CC(=CC=C1)OC(F)(F)F VCUFZILGIRCDQQ-KRWDZBQOSA-N 0.000 description 9
• 235000004279 alanine Nutrition 0.000 description 9
• 230000002494 anti-cea effect Effects 0.000 description 9
• 230000004927 fusion Effects 0.000 description 9
• 210000000056 organ Anatomy 0.000 description 9
• 239000008194 pharmaceutical composition Substances 0.000 description 9
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 9
• 239000002516 radical scavenger Substances 0.000 description 9
• 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 description 8
• 108020004414 DNA Proteins 0.000 description 8
• 102000053602 DNA Human genes 0.000 description 8
• 239000004471 Glycine Substances 0.000 description 8
• KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 description 8
• MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 description 8
• 125000005115 alkyl carbamoyl group Chemical group 0.000 description 8
• 238000004458 analytical method Methods 0.000 description 8
• 125000004093 cyano group Chemical group *C#N 0.000 description 8
• 238000002474 experimental method Methods 0.000 description 8
• 230000001976 improved effect Effects 0.000 description 8
• 229920000642 polymer Polymers 0.000 description 8
• 210000004881 tumor cell Anatomy 0.000 description 8
• 206010009944 Colon cancer Diseases 0.000 description 7
• 238000002965 ELISA Methods 0.000 description 7
• 238000012413 Fluorescence activated cell sorting analysis Methods 0.000 description 7
• KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 description 7
• 239000004472 Lysine Substances 0.000 description 7
• 239000002202 Polyethylene glycol Substances 0.000 description 7
• 239000002253 acid Substances 0.000 description 7
• 239000000872 buffer Substances 0.000 description 7
• 238000002619 cancer immunotherapy Methods 0.000 description 7
• 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 7
• 239000003814 drug Substances 0.000 description 7
• 229910052736 halogen Inorganic materials 0.000 description 7
• 238000001990 intravenous administration Methods 0.000 description 7
• 238000004519 manufacturing process Methods 0.000 description 7
• 238000005259 measurement Methods 0.000 description 7
• 229920001223 polyethylene glycol Polymers 0.000 description 7
• 102000005962 receptors Human genes 0.000 description 7
• 108020003175 receptors Proteins 0.000 description 7
• 150000003839 salts Chemical class 0.000 description 7
• 238000002198 surface plasmon resonance spectroscopy Methods 0.000 description 7
• YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 description 6
• 125000004765 (C1-C4) haloalkyl group Chemical group 0.000 description 6
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 description 6
• 125000001433 C-terminal amino-acid group Chemical group 0.000 description 6
• 229920002307 Dextran Polymers 0.000 description 6
• 241000588724 Escherichia coli Species 0.000 description 6
• 102100041003 Glutamate carboxypeptidase 2 Human genes 0.000 description 6
• 101000892862 Homo sapiens Glutamate carboxypeptidase 2 Proteins 0.000 description 6
• 102000006496 Immunoglobulin Heavy Chains Human genes 0.000 description 6
• 108010019476 Immunoglobulin Heavy Chains Proteins 0.000 description 6
• 229910052765 Lutetium Inorganic materials 0.000 description 6
• 241001465754 Metazoa Species 0.000 description 6
• 241001529936 Murinae Species 0.000 description 6
• 102100025243 Myeloid cell surface antigen CD33 Human genes 0.000 description 6
• DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 6
• 108010076504 Protein Sorting Signals Proteins 0.000 description 6
• 125000003545 alkoxy group Chemical group 0.000 description 6
• 210000003719 b-lymphocyte Anatomy 0.000 description 6
• 229910052799 carbon Inorganic materials 0.000 description 6
• 229920001577 copolymer Polymers 0.000 description 6
• 238000005516 engineering process Methods 0.000 description 6
• 239000013613 expression plasmid Substances 0.000 description 6
• 150000002367 halogens Chemical class 0.000 description 6
• 239000000833 heterodimer Substances 0.000 description 6
• 238000003384 imaging method Methods 0.000 description 6
• 238000011534 incubation Methods 0.000 description 6
• 238000007912 intraperitoneal administration Methods 0.000 description 6
• 125000003729 nucleotide group Chemical group 0.000 description 6
• 230000010076 replication Effects 0.000 description 6
• 229920002477 rna polymer Polymers 0.000 description 6
• 230000001225 therapeutic effect Effects 0.000 description 6
• 230000003827 upregulation Effects 0.000 description 6
• 229910052727 yttrium Inorganic materials 0.000 description 6
• 125000004767 (C1-C4) haloalkoxy group Chemical group 0.000 description 5
• 102100038080 B-cell receptor CD22 Human genes 0.000 description 5
• 108010074708 B7-H1 Antigen Proteins 0.000 description 5
• 206010006187 Breast cancer Diseases 0.000 description 5
• 208000026310 Breast neoplasm Diseases 0.000 description 5
• 108010029697 CD40 Ligand Proteins 0.000 description 5
• 102100032937 CD40 ligand Human genes 0.000 description 5
• 229940045513 CTLA4 antagonist Drugs 0.000 description 5
• 208000001333 Colorectal Neoplasms Diseases 0.000 description 5
• 101100099884 Homo sapiens CD40 gene Proteins 0.000 description 5
• 102100026120 IgG receptor FcRn large subunit p51 Human genes 0.000 description 5
• 101710177940 IgG receptor FcRn large subunit p51 Proteins 0.000 description 5
• AYFVYJQAPQTCCC-GBXIJSLDSA-N L-threonine Chemical compound C[C@@H](O)[C@H](N)C(O)=O AYFVYJQAPQTCCC-GBXIJSLDSA-N 0.000 description 5
• 241000699666 Mus <mouse, genus> Species 0.000 description 5
• OVRNDRQMDRJTHS-UHFFFAOYSA-N N-acelyl-D-glucosamine Natural products CC(=O)NC1C(O)OC(CO)C(O)C1O OVRNDRQMDRJTHS-UHFFFAOYSA-N 0.000 description 5
• MBLBDJOUHNCFQT-LXGUWJNJSA-N N-acetylglucosamine Natural products CC(=O)N[C@@H](C=O)[C@@H](O)[C@H](O)[C@H](O)CO MBLBDJOUHNCFQT-LXGUWJNJSA-N 0.000 description 5
• 206010061902 Pancreatic neoplasm Diseases 0.000 description 5
• 125000004448 alkyl carbonyl group Chemical group 0.000 description 5
• 230000008901 benefit Effects 0.000 description 5
• 229960002685 biotin Drugs 0.000 description 5
• 239000011616 biotin Substances 0.000 description 5
• 150000001720 carbohydrates Chemical class 0.000 description 5
• 235000014633 carbohydrates Nutrition 0.000 description 5
• 230000008859 change Effects 0.000 description 5
• 238000001514 detection method Methods 0.000 description 5
• 239000003937 drug carrier Substances 0.000 description 5
• MHMNJMPURVTYEJ-UHFFFAOYSA-N fluorescein-5-isothiocyanate Chemical compound O1C(=O)C2=CC(N=C=S)=CC=C2C21C1=CC=C(O)C=C1OC1=CC(O)=CC=C21 MHMNJMPURVTYEJ-UHFFFAOYSA-N 0.000 description 5
• 238000001943 fluorescence-activated cell sorting Methods 0.000 description 5
• 230000013595 glycosylation Effects 0.000 description 5
• 238000006206 glycosylation reaction Methods 0.000 description 5
• 229910052739 hydrogen Inorganic materials 0.000 description 5
• 230000003993 interaction Effects 0.000 description 5
• 208000020816 lung neoplasm Diseases 0.000 description 5
• 108020004999 messenger RNA Proteins 0.000 description 5
• 229910021645 metal ion Inorganic materials 0.000 description 5
• 150000002739 metals Chemical class 0.000 description 5
• 239000002773 nucleotide Substances 0.000 description 5
• 238000001543 one-way ANOVA Methods 0.000 description 5
• 239000000047 product Substances 0.000 description 5
• 239000002534 radiation-sensitizing agent Substances 0.000 description 5
• 125000001424 substituent group Chemical group 0.000 description 5
• 208000010839 B-cell chronic lymphocytic leukemia Diseases 0.000 description 4
• 102100022005 B-lymphocyte antigen CD20 Human genes 0.000 description 4
• KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 4
• 102000001301 EGF receptor Human genes 0.000 description 4
• 108010087819 Fc receptors Proteins 0.000 description 4
• 102000009109 Fc receptors Human genes 0.000 description 4
• 101000884305 Homo sapiens B-cell receptor CD22 Proteins 0.000 description 4
• 101000897405 Homo sapiens B-lymphocyte antigen CD20 Proteins 0.000 description 4
• 101000934338 Homo sapiens Myeloid cell surface antigen CD33 Proteins 0.000 description 4
• QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 description 4
• SHZGCJCMOBCMKK-DHVFOXMCSA-N L-fucopyranose Chemical compound C[C@@H]1OC(O)[C@@H](O)[C@H](O)[C@@H]1O SHZGCJCMOBCMKK-DHVFOXMCSA-N 0.000 description 4
• 206010058467 Lung neoplasm malignant Diseases 0.000 description 4
• 206010025323 Lymphomas Diseases 0.000 description 4
• 241000124008 Mammalia Species 0.000 description 4
• OVRNDRQMDRJTHS-RTRLPJTCSA-N N-acetyl-D-glucosamine Chemical compound CC(=O)N[C@H]1C(O)O[C@H](CO)[C@@H](O)[C@@H]1O OVRNDRQMDRJTHS-RTRLPJTCSA-N 0.000 description 4
• 125000000729 N-terminal amino-acid group Chemical group 0.000 description 4
• 206010061535 Ovarian neoplasm Diseases 0.000 description 4
• 206010060862 Prostate cancer Diseases 0.000 description 4
• 208000000236 Prostatic Neoplasms Diseases 0.000 description 4
• 208000005718 Stomach Neoplasms Diseases 0.000 description 4
• 102100027212 Tumor-associated calcium signal transducer 2 Human genes 0.000 description 4
• 208000007097 Urinary Bladder Neoplasms Diseases 0.000 description 4
• 125000004453 alkoxycarbonyl group Chemical group 0.000 description 4
• 230000004075 alteration Effects 0.000 description 4
• 125000003118 aryl group Chemical group 0.000 description 4
• 239000011324 bead Substances 0.000 description 4
• 230000015572 biosynthetic process Effects 0.000 description 4
• 229910052797 bismuth Inorganic materials 0.000 description 4
• 210000004369 blood Anatomy 0.000 description 4
• 239000008280 blood Substances 0.000 description 4
• 238000013368 capillary electrophoresis sodium dodecyl sulfate analysis Methods 0.000 description 4
• 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 description 4
• 229940127089 cytotoxic agent Drugs 0.000 description 4
• 210000004443 dendritic cell Anatomy 0.000 description 4
• UQLDLKMNUJERMK-UHFFFAOYSA-L di(octadecanoyloxy)lead Chemical compound [Pb+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O UQLDLKMNUJERMK-UHFFFAOYSA-L 0.000 description 4
• 229940079593 drug Drugs 0.000 description 4
• 238000011067 equilibration Methods 0.000 description 4
• 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 4
• 238000013401 experimental design Methods 0.000 description 4
• 238000009472 formulation Methods 0.000 description 4
• 206010017758 gastric cancer Diseases 0.000 description 4
• 125000003630 glycyl group Chemical group [H]N([H])C([H])([H])C(*)=O 0.000 description 4
• 208000014829 head and neck neoplasm Diseases 0.000 description 4
• 239000012535 impurity Substances 0.000 description 4
• 229910052745 lead Inorganic materials 0.000 description 4
• 201000005202 lung cancer Diseases 0.000 description 4
• 208000015486 malignant pancreatic neoplasm Diseases 0.000 description 4
• 238000002703 mutagenesis Methods 0.000 description 4
• 231100000350 mutagenesis Toxicity 0.000 description 4
• 201000002528 pancreatic cancer Diseases 0.000 description 4
• 208000008443 pancreatic carcinoma Diseases 0.000 description 4
• 229960002621 pembrolizumab Drugs 0.000 description 4
• 239000013612 plasmid Substances 0.000 description 4
• 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 description 4
• 238000002360 preparation method Methods 0.000 description 4
• 239000000523 sample Substances 0.000 description 4
• 238000013207 serial dilution Methods 0.000 description 4
• 210000002966 serum Anatomy 0.000 description 4
• 238000011269 treatment regimen Methods 0.000 description 4
• GOJUJUVQIVIZAV-UHFFFAOYSA-N 2-amino-4,6-dichloropyrimidine-5-carbaldehyde Chemical group NC1=NC(Cl)=C(C=O)C(Cl)=N1 GOJUJUVQIVIZAV-UHFFFAOYSA-N 0.000 description 3
• 108020003589 5' Untranslated Regions Proteins 0.000 description 3
• 239000004475 Arginine Substances 0.000 description 3
• WVDDGKGOMKODPV-UHFFFAOYSA-N Benzyl alcohol Chemical compound OCC1=CC=CC=C1 WVDDGKGOMKODPV-UHFFFAOYSA-N 0.000 description 3
• 125000003830 C1- C4 alkylcarbonylamino group Chemical group 0.000 description 3
• 102100024423 Carbonic anhydrase 9 Human genes 0.000 description 3
• 108020004635 Complementary DNA Proteins 0.000 description 3
• WQZGKKKJIJFFOK-QTVWNMPRSA-N D-mannopyranose Chemical compound OC[C@H]1OC(O)[C@@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-QTVWNMPRSA-N 0.000 description 3
• 108090000204 Dipeptidase 1 Proteins 0.000 description 3
• 108060006698 EGF receptor Proteins 0.000 description 3
• 208000000461 Esophageal Neoplasms Diseases 0.000 description 3
• LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 3
• 102100021197 G-protein coupled receptor family C group 5 member D Human genes 0.000 description 3
• WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 description 3
• PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 3
• 241000282412 Homo Species 0.000 description 3
• 101001040713 Homo sapiens G-protein coupled receptor family C group 5 member D Proteins 0.000 description 3
• 101001057504 Homo sapiens Interferon-stimulated gene 20 kDa protein Proteins 0.000 description 3
• 101001055144 Homo sapiens Interleukin-2 receptor subunit alpha Proteins 0.000 description 3
• 241000701024 Human betaherpesvirus 5 Species 0.000 description 3
• 102100022297 Integrin alpha-X Human genes 0.000 description 3
• 102100027268 Interferon-stimulated gene 20 kDa protein Human genes 0.000 description 3
• 208000008839 Kidney Neoplasms Diseases 0.000 description 3
• DCXYFEDJOCDNAF-REOHCLBHSA-N L-asparagine Chemical compound OC(=O)[C@@H](N)CC(N)=O DCXYFEDJOCDNAF-REOHCLBHSA-N 0.000 description 3
• CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 description 3
• OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 description 3
• 108091026898 Leader sequence (mRNA) Proteins 0.000 description 3
• 102100029193 Low affinity immunoglobulin gamma Fc region receptor III-A Human genes 0.000 description 3
• 208000031422 Lymphocytic Chronic B-Cell Leukemia Diseases 0.000 description 3
• 108090000015 Mesothelin Proteins 0.000 description 3
• 102000003735 Mesothelin Human genes 0.000 description 3
• 206010027406 Mesothelioma Diseases 0.000 description 3
• 238000011887 Necropsy Methods 0.000 description 3
• 206010033128 Ovarian cancer Diseases 0.000 description 3
• 229920001213 Polysorbate 20 Polymers 0.000 description 3
• 101710094000 Programmed cell death 1 ligand 1 Proteins 0.000 description 3
• 102100023832 Prolyl endopeptidase FAP Human genes 0.000 description 3
• 208000006265 Renal cell carcinoma Diseases 0.000 description 3
• AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 description 3
• 239000004473 Threonine Substances 0.000 description 3
• 102100033579 Trophoblast glycoprotein Human genes 0.000 description 3
• 101710165474 Tumor necrosis factor receptor superfamily member 5 Proteins 0.000 description 3
• 230000009824 affinity maturation Effects 0.000 description 3
• 238000012867 alanine scanning Methods 0.000 description 3
• 125000004450 alkenylene group Chemical group 0.000 description 3
• 125000004466 alkoxycarbonylamino group Chemical group 0.000 description 3
• 125000004419 alkynylene group Chemical group 0.000 description 3
• AVKUERGKIZMTKX-NJBDSQKTSA-N ampicillin Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C(O)=O)(C)C)=CC=CC=C1 AVKUERGKIZMTKX-NJBDSQKTSA-N 0.000 description 3
• 229960000723 ampicillin Drugs 0.000 description 3
• 239000002246 antineoplastic agent Substances 0.000 description 3
• ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 description 3
• 235000020958 biotin Nutrition 0.000 description 3
• 239000002981 blocking agent Substances 0.000 description 3
• 108010006025 bovine growth hormone Proteins 0.000 description 3
• 210000000481 breast Anatomy 0.000 description 3
• 239000006227 byproduct Substances 0.000 description 3
• 238000010804 cDNA synthesis Methods 0.000 description 3
• 239000003153 chemical reaction reagent Substances 0.000 description 3
• 208000029742 colonic neoplasm Diseases 0.000 description 3
• 230000000295 complement effect Effects 0.000 description 3
• 239000002299 complementary DNA Substances 0.000 description 3
• 238000002784 cytotoxicity assay Methods 0.000 description 3
• 231100000263 cytotoxicity test Toxicity 0.000 description 3
• 238000011161 development Methods 0.000 description 3
• 230000018109 developmental process Effects 0.000 description 3
• 238000004980 dosimetry Methods 0.000 description 3
• 239000003623 enhancer Substances 0.000 description 3
• 108010072257 fibroblast activation protein alpha Proteins 0.000 description 3
• 230000033581 fucosylation Effects 0.000 description 3
• HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 description 3
• 125000002887 hydroxy group Chemical group [H]O* 0.000 description 3
• 230000001900 immune effect Effects 0.000 description 3
• 229940072221 immunoglobulins Drugs 0.000 description 3
• 238000001802 infusion Methods 0.000 description 3
• 230000005764 inhibitory process Effects 0.000 description 3
• 238000011221 initial treatment Methods 0.000 description 3
• 229940065638 intron a Drugs 0.000 description 3
• 150000002500 ions Chemical class 0.000 description 3
• 238000012004 kinetic exclusion assay Methods 0.000 description 3
• 239000003446 ligand Substances 0.000 description 3
• 230000035800 maturation Effects 0.000 description 3
• 238000010172 mouse model Methods 0.000 description 3
• 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 description 3
• 229960003301 nivolumab Drugs 0.000 description 3
• 201000008129 pancreatic ductal adenocarcinoma Diseases 0.000 description 3
• 230000037361 pathway Effects 0.000 description 3
• 230000008488 polyadenylation Effects 0.000 description 3
• 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 description 3
• 230000002265 prevention Effects 0.000 description 3
• 238000000159 protein binding assay Methods 0.000 description 3
• 230000009467 reduction Effects 0.000 description 3
• 230000000717 retained effect Effects 0.000 description 3
• 238000012552 review Methods 0.000 description 3
• 238000009738 saturating Methods 0.000 description 3
• 150000003384 small molecules Chemical class 0.000 description 3
• 239000007787 solid Substances 0.000 description 3
• 239000000243 solution Substances 0.000 description 3
• 241000894007 species Species 0.000 description 3
• 201000011549 stomach cancer Diseases 0.000 description 3
• 239000000126 substance Substances 0.000 description 3
• 235000000346 sugar Nutrition 0.000 description 3
• 238000002560 therapeutic procedure Methods 0.000 description 3
• 238000013518 transcription Methods 0.000 description 3
• 230000035897 transcription Effects 0.000 description 3
• 238000001890 transfection Methods 0.000 description 3
• 230000009261 transgenic effect Effects 0.000 description 3
• 230000010474 transient expression Effects 0.000 description 3
• 125000004768 (C1-C4) alkylsulfinyl group Chemical group 0.000 description 2
• 125000004769 (C1-C4) alkylsulfonyl group Chemical group 0.000 description 2
• 125000004454 (C1-C6) alkoxycarbonyl group Chemical group 0.000 description 2
• JLVSRWOIZZXQAD-UHFFFAOYSA-N 2,3-disulfanylpropane-1-sulfonic acid Chemical compound OS(=O)(=O)CC(S)CS JLVSRWOIZZXQAD-UHFFFAOYSA-N 0.000 description 2
• HZAXFHJVJLSVMW-UHFFFAOYSA-N 2-Aminoethan-1-ol Chemical compound NCCO HZAXFHJVJLSVMW-UHFFFAOYSA-N 0.000 description 2
• RAEOEMDZDMCHJA-UHFFFAOYSA-N 2-[2-[bis(carboxymethyl)amino]ethyl-[2-[2-[bis(carboxymethyl)amino]ethyl-(carboxymethyl)amino]ethyl]amino]acetic acid Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(=O)O)CCN(CCN(CC(O)=O)CC(O)=O)CC(O)=O RAEOEMDZDMCHJA-UHFFFAOYSA-N 0.000 description 2
• RXACEEPNTRHYBQ-UHFFFAOYSA-N 2-[[2-[[2-[(2-sulfanylacetyl)amino]acetyl]amino]acetyl]amino]acetic acid Chemical compound OC(=O)CNC(=O)CNC(=O)CNC(=O)CS RXACEEPNTRHYBQ-UHFFFAOYSA-N 0.000 description 2
• FPQQSJJWHUJYPU-UHFFFAOYSA-N 3-(dimethylamino)propyliminomethylidene-ethylazanium;chloride Chemical compound Cl.CCN=C=NCCCN(C)C FPQQSJJWHUJYPU-UHFFFAOYSA-N 0.000 description 2
• 208000024893 Acute lymphoblastic leukemia Diseases 0.000 description 2
• 208000014697 Acute lymphocytic leukaemia Diseases 0.000 description 2
• 208000031261 Acute myeloid leukaemia Diseases 0.000 description 2
• 108010088751 Albumins Proteins 0.000 description 2
• 102000009027 Albumins Human genes 0.000 description 2
• 108010032595 Antibody Binding Sites Proteins 0.000 description 2
• 101100321445 Arabidopsis thaliana ZHD3 gene Proteins 0.000 description 2
• CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
• 108091003079 Bovine Serum Albumin Proteins 0.000 description 2
• 108700012439 CA9 Proteins 0.000 description 2
• 101710190849 Carcinoembryonic antigen-related cell adhesion molecule 5 Proteins 0.000 description 2
• 102100028757 Chondroitin sulfate proteoglycan 4 Human genes 0.000 description 2
• PHEDXBVPIONUQT-UHFFFAOYSA-N Cocarcinogen A1 Natural products CCCCCCCCCCCCCC(=O)OC1C(C)C2(O)C3C=C(C)C(=O)C3(O)CC(CO)=CC2C2C1(OC(C)=O)C2(C)C PHEDXBVPIONUQT-UHFFFAOYSA-N 0.000 description 2
• SHZGCJCMOBCMKK-UHFFFAOYSA-N D-mannomethylose Natural products CC1OC(O)C(O)C(O)C1O SHZGCJCMOBCMKK-UHFFFAOYSA-N 0.000 description 2
• 108700022150 Designed Ankyrin Repeat Proteins Proteins 0.000 description 2
• 229920001353 Dextrin Polymers 0.000 description 2
• 239000004375 Dextrin Substances 0.000 description 2
• 108010024212 E-Selectin Proteins 0.000 description 2
• 102100023471 E-selectin Human genes 0.000 description 2
• 101150029707 ERBB2 gene Proteins 0.000 description 2
• 102000004190 Enzymes Human genes 0.000 description 2
• 108090000790 Enzymes Proteins 0.000 description 2
• 102100031968 Ephrin type-B receptor 2 Human genes 0.000 description 2
• 201000001342 Fallopian tube cancer Diseases 0.000 description 2
• 208000013452 Fallopian tube neoplasm Diseases 0.000 description 2
• WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 2
• PNNNRSAQSRJVSB-SLPGGIOYSA-N Fucose Natural products C[C@H](O)[C@@H](O)[C@H](O)[C@H](O)C=O PNNNRSAQSRJVSB-SLPGGIOYSA-N 0.000 description 2
• 102000003886 Glycoproteins Human genes 0.000 description 2
• 108090000288 Glycoproteins Proteins 0.000 description 2
• 102000016355 Granulocyte-Macrophage Colony-Stimulating Factor Receptors Human genes 0.000 description 2
• 108010092372 Granulocyte-Macrophage Colony-Stimulating Factor Receptors Proteins 0.000 description 2
• 102100040892 Growth/differentiation factor 2 Human genes 0.000 description 2
• 208000017604 Hodgkin disease Diseases 0.000 description 2
• 208000010747 Hodgkins lymphoma Diseases 0.000 description 2
• 101000916489 Homo sapiens Chondroitin sulfate proteoglycan 4 Proteins 0.000 description 2
• 101001046686 Homo sapiens Integrin alpha-M Proteins 0.000 description 2
• 101001095088 Homo sapiens Melanoma antigen preferentially expressed in tumors Proteins 0.000 description 2
• 101001133056 Homo sapiens Mucin-1 Proteins 0.000 description 2
• 101000581981 Homo sapiens Neural cell adhesion molecule 1 Proteins 0.000 description 2
• 101001136592 Homo sapiens Prostate stem cell antigen Proteins 0.000 description 2
• 101001012157 Homo sapiens Receptor tyrosine-protein kinase erbB-2 Proteins 0.000 description 2
• 101000801433 Homo sapiens Trophoblast glycoprotein Proteins 0.000 description 2
• 101000851376 Homo sapiens Tumor necrosis factor receptor superfamily member 8 Proteins 0.000 description 2
• 229920001612 Hydroxyethyl starch Polymers 0.000 description 2
• 108010073807 IgG Receptors Proteins 0.000 description 2
• 102100022338 Integrin alpha-M Human genes 0.000 description 2
• XUJNEKJLAYXESH-REOHCLBHSA-N L-Cysteine Chemical compound SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 description 2
• ZDXPYRJPNDTMRX-VKHMYHEASA-N L-glutamine Chemical compound OC(=O)[C@@H](N)CCC(N)=O ZDXPYRJPNDTMRX-VKHMYHEASA-N 0.000 description 2
• HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 description 2
• COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 description 2
• 108060001084 Luciferase Proteins 0.000 description 2
• 239000005089 Luciferase Substances 0.000 description 2
• 102000043136 MAP kinase family Human genes 0.000 description 2
• 108091054455 MAP kinase family Proteins 0.000 description 2
• 102100037020 Melanoma antigen preferentially expressed in tumors Human genes 0.000 description 2
• 208000033833 Myelomonocytic Chronic Leukemia Diseases 0.000 description 2
• QPCDCPDFJACHGM-UHFFFAOYSA-N N,N-bis{2-[bis(carboxymethyl)amino]ethyl}glycine Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(=O)O)CCN(CC(O)=O)CC(O)=O QPCDCPDFJACHGM-UHFFFAOYSA-N 0.000 description 2
• 125000001429 N-terminal alpha-amino-acid group Chemical group 0.000 description 2
• 102000003945 NF-kappa B Human genes 0.000 description 2
• 108010057466 NF-kappa B Proteins 0.000 description 2
• 108010012255 Neural Cell Adhesion Molecule L1 Proteins 0.000 description 2
• 102100027347 Neural cell adhesion molecule 1 Human genes 0.000 description 2
• 102100024964 Neural cell adhesion molecule L1 Human genes 0.000 description 2
• 108010038807 Oligopeptides Proteins 0.000 description 2
• 102000015636 Oligopeptides Human genes 0.000 description 2
• 241000283973 Oryctolagus cuniculus Species 0.000 description 2
• 101710160107 Outer membrane protein A Proteins 0.000 description 2
• ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Natural products OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 2
• 108091000080 Phosphotransferase Proteins 0.000 description 2
• 239000004372 Polyvinyl alcohol Substances 0.000 description 2
• 208000006664 Precursor Cell Lymphoblastic Leukemia-Lymphoma Diseases 0.000 description 2
• 241000288906 Primates Species 0.000 description 2
• 208000033766 Prolymphocytic Leukemia Diseases 0.000 description 2
• NBBJYMSMWIIQGU-UHFFFAOYSA-N Propionic aldehyde Chemical compound CCC=O NBBJYMSMWIIQGU-UHFFFAOYSA-N 0.000 description 2
• 102100036735 Prostate stem cell antigen Human genes 0.000 description 2
• 241000700159 Rattus Species 0.000 description 2
• 102100030086 Receptor tyrosine-protein kinase erbB-2 Human genes 0.000 description 2
• 206010038389 Renal cancer Diseases 0.000 description 2
• 241000283984 Rodentia Species 0.000 description 2
• 108010003723 Single-Domain Antibodies Proteins 0.000 description 2
• CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 2
• 108010090804 Streptavidin Proteins 0.000 description 2
• JVHROZDXPAUZFK-UHFFFAOYSA-N TETA Chemical compound OC(=O)CN1CCCN(CC(O)=O)CCN(CC(O)=O)CCCN(CC(O)=O)CC1 JVHROZDXPAUZFK-UHFFFAOYSA-N 0.000 description 2
• 108010033576 Transferrin Receptors Proteins 0.000 description 2
• 102100026144 Transferrin receptor protein 1 Human genes 0.000 description 2
• 108060008683 Tumor Necrosis Factor Receptor Proteins 0.000 description 2
• 102100036857 Tumor necrosis factor receptor superfamily member 8 Human genes 0.000 description 2
• ISAKRJDGNUQOIC-UHFFFAOYSA-N Uracil Chemical compound O=C1C=CNC(=O)N1 ISAKRJDGNUQOIC-UHFFFAOYSA-N 0.000 description 2
• 208000002495 Uterine Neoplasms Diseases 0.000 description 2
• 231100000987 absorbed dose Toxicity 0.000 description 2
• 125000003342 alkenyl group Chemical group 0.000 description 2
• 125000004414 alkyl thio group Chemical group 0.000 description 2
• 125000000304 alkynyl group Chemical group 0.000 description 2
• WQZGKKKJIJFFOK-PHYPRBDBSA-N alpha-D-galactose Chemical compound OC[C@H]1O[C@H](O)[C@H](O)[C@@H](O)[C@H]1O WQZGKKKJIJFFOK-PHYPRBDBSA-N 0.000 description 2
• MXKCYTKUIDTFLY-ZNNSSXPHSA-N alpha-L-Fucp-(1->2)-beta-D-Galp-(1->4)-[alpha-L-Fucp-(1->3)]-beta-D-GlcpNAc-(1->3)-D-Galp Chemical compound O[C@H]1[C@H](O)[C@H](O)[C@H](C)O[C@H]1O[C@H]1[C@H](O[C@H]2[C@@H]([C@@H](NC(C)=O)[C@H](O[C@H]3[C@H]([C@@H](CO)OC(O)[C@@H]3O)O)O[C@@H]2CO)O[C@H]2[C@H]([C@H](O)[C@H](O)[C@H](C)O2)O)O[C@H](CO)[C@H](O)[C@@H]1O MXKCYTKUIDTFLY-ZNNSSXPHSA-N 0.000 description 2
• LBDSXVIYZYSRII-IGMARMGPSA-N alpha-particle Chemical compound [4He+2] LBDSXVIYZYSRII-IGMARMGPSA-N 0.000 description 2
• 229950001537 amatuximab Drugs 0.000 description 2
• 210000000612 antigen-presenting cell Anatomy 0.000 description 2
• 230000000890 antigenic effect Effects 0.000 description 2
• 238000013459 approach Methods 0.000 description 2
• 229920006187 aquazol Polymers 0.000 description 2
• 239000012861 aquazol Substances 0.000 description 2
• 229950002916 avelumab Drugs 0.000 description 2
• 229940098773 bovine serum albumin Drugs 0.000 description 2
• RYYVLZVUVIJVGH-UHFFFAOYSA-N caffeine Chemical compound CN1C(=O)N(C)C(=O)C2=C1N=CN2C RYYVLZVUVIJVGH-UHFFFAOYSA-N 0.000 description 2
• YCIMNLLNPGFGHC-UHFFFAOYSA-N catechol Chemical compound OC1=CC=CC=C1O YCIMNLLNPGFGHC-UHFFFAOYSA-N 0.000 description 2
• 238000004113 cell culture Methods 0.000 description 2
• 230000022534 cell killing Effects 0.000 description 2
• 210000003169 central nervous system Anatomy 0.000 description 2
• 210000004978 chinese hamster ovary cell Anatomy 0.000 description 2
• 230000002759 chromosomal effect Effects 0.000 description 2
• 201000010902 chronic myelomonocytic leukemia Diseases 0.000 description 2
• 230000009137 competitive binding Effects 0.000 description 2
• 238000004590 computer program Methods 0.000 description 2
• 238000012937 correction Methods 0.000 description 2
• 125000000753 cycloalkyl group Chemical group 0.000 description 2
• 235000018417 cysteine Nutrition 0.000 description 2
• OPTASPLRGRRNAP-UHFFFAOYSA-N cytosine Chemical compound NC=1C=CNC(=O)N=1 OPTASPLRGRRNAP-UHFFFAOYSA-N 0.000 description 2
• 231100000433 cytotoxic Toxicity 0.000 description 2
• 230000001472 cytotoxic effect Effects 0.000 description 2
• 230000006378 damage Effects 0.000 description 2
• 230000007423 decrease Effects 0.000 description 2
• 230000001419 dependent effect Effects 0.000 description 2
• 238000001212 derivatisation Methods 0.000 description 2
• 235000019425 dextrin Nutrition 0.000 description 2
• 208000035475 disorder Diseases 0.000 description 2
• 231100000673 dose–response relationship Toxicity 0.000 description 2
• 229950009791 durvalumab Drugs 0.000 description 2
• PZZHMLOHNYWKIK-UHFFFAOYSA-N eddha Chemical compound C=1C=CC=C(O)C=1C(C(=O)O)NCCNC(C(O)=O)C1=CC=CC=C1O PZZHMLOHNYWKIK-UHFFFAOYSA-N 0.000 description 2
• 229940088598 enzyme Drugs 0.000 description 2
• 210000002950 fibroblast Anatomy 0.000 description 2
• 238000000684 flow cytometry Methods 0.000 description 2
• 210000004602 germ cell Anatomy 0.000 description 2
• UYTPUPDQBNUYGX-UHFFFAOYSA-N guanine Chemical compound O=C1NC(N)=NC2=C1N=CN2 UYTPUPDQBNUYGX-UHFFFAOYSA-N 0.000 description 2
• 201000009277 hairy cell leukemia Diseases 0.000 description 2
• 125000005843 halogen group Chemical group 0.000 description 2
• 201000010536 head and neck cancer Diseases 0.000 description 2
• 230000036541 health Effects 0.000 description 2
• 229920001519 homopolymer Polymers 0.000 description 2
• 102000048776 human CD274 Human genes 0.000 description 2
• 229920001477 hydrophilic polymer Polymers 0.000 description 2
• DNZMDASEFMLYBU-RNBXVSKKSA-N hydroxyethyl starch Chemical compound OC[C@H]1O[C@H](O)[C@H](O)[C@@H](O)[C@@H]1O.OCCOC[C@H]1O[C@H](OCCO)[C@H](OCCO)[C@@H](OCCO)[C@@H]1OCCO DNZMDASEFMLYBU-RNBXVSKKSA-N 0.000 description 2
• 229940050526 hydroxyethylstarch Drugs 0.000 description 2
• NBZBKCUXIYYUSX-UHFFFAOYSA-N iminodiacetic acid Chemical compound OC(=O)CNCC(O)=O NBZBKCUXIYYUSX-UHFFFAOYSA-N 0.000 description 2
• 210000002865 immune cell Anatomy 0.000 description 2
• 230000002163 immunogen Effects 0.000 description 2
• 230000005847 immunogenicity Effects 0.000 description 2
• 230000006872 improvement Effects 0.000 description 2
• 238000000338 in vitro Methods 0.000 description 2
• 238000001155 isoelectric focusing Methods 0.000 description 2
• 201000010982 kidney cancer Diseases 0.000 description 2
• 210000003292 kidney cell Anatomy 0.000 description 2
• 208000032839 leukemia Diseases 0.000 description 2
• 210000004072 lung Anatomy 0.000 description 2
• RLSSMJSEOOYNOY-UHFFFAOYSA-N m-cresol Chemical compound CC1=CC=CC(O)=C1 RLSSMJSEOOYNOY-UHFFFAOYSA-N 0.000 description 2
• 239000011159 matrix material Substances 0.000 description 2
• 230000001404 mediated effect Effects 0.000 description 2
• 201000001441 melanoma Diseases 0.000 description 2
• MYWUZJCMWCOHBA-VIFPVBQESA-N methamphetamine Chemical compound CN[C@@H](C)CC1=CC=CC=C1 MYWUZJCMWCOHBA-VIFPVBQESA-N 0.000 description 2
• 125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 description 2
• 239000003094 microcapsule Substances 0.000 description 2
• 230000007935 neutral effect Effects 0.000 description 2
• 208000002154 non-small cell lung carcinoma Diseases 0.000 description 2
• 231100000252 nontoxic Toxicity 0.000 description 2
• 230000003000 nontoxic effect Effects 0.000 description 2
• 230000036407 pain Effects 0.000 description 2
• 230000007170 pathology Effects 0.000 description 2
• AQIXEPGDORPWBJ-UHFFFAOYSA-N pentan-3-ol Chemical compound CCC(O)CC AQIXEPGDORPWBJ-UHFFFAOYSA-N 0.000 description 2
• 229960003330 pentetic acid Drugs 0.000 description 2
• 210000003819 peripheral blood mononuclear cell Anatomy 0.000 description 2
• 238000002823 phage display Methods 0.000 description 2
• PHEDXBVPIONUQT-RGYGYFBISA-N phorbol 13-acetate 12-myristate Chemical compound C([C@]1(O)C(=O)C(C)=C[C@H]1[C@@]1(O)[C@H](C)[C@H]2OC(=O)CCCCCCCCCCCCC)C(CO)=C[C@H]1[C@H]1[C@]2(OC(C)=O)C1(C)C PHEDXBVPIONUQT-RGYGYFBISA-N 0.000 description 2
• 125000002467 phosphate group Chemical group [H]OP(=O)(O[H])O[*] 0.000 description 2
• 102000020233 phosphotransferase Human genes 0.000 description 2
• 229940068977 polysorbate 20 Drugs 0.000 description 2
• 229920002451 polyvinyl alcohol Polymers 0.000 description 2
• 229920000036 polyvinylpyrrolidone Polymers 0.000 description 2
• 239000001267 polyvinylpyrrolidone Substances 0.000 description 2
• 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 2
• 239000003755 preservative agent Substances 0.000 description 2
• QELSKZZBTMNZEB-UHFFFAOYSA-N propylparaben Chemical compound CCCOC(=O)C1=CC=C(O)C=C1 QELSKZZBTMNZEB-UHFFFAOYSA-N 0.000 description 2
• 230000005180 public health Effects 0.000 description 2
• 230000005258 radioactive decay Effects 0.000 description 2
• 239000002287 radioligand Substances 0.000 description 2
• 238000003259 recombinant expression Methods 0.000 description 2
• 238000011160 research Methods 0.000 description 2
• GHMLBKRAJCXXBS-UHFFFAOYSA-N resorcinol Chemical compound OC1=CC=CC(O)=C1 GHMLBKRAJCXXBS-UHFFFAOYSA-N 0.000 description 2
• 230000002441 reversible effect Effects 0.000 description 2
• 102220215713 rs772873692 Human genes 0.000 description 2
• 239000012723 sample buffer Substances 0.000 description 2
• 125000003607 serino group Chemical group [H]N([H])[C@]([H])(C(=O)[*])C(O[H])([H])[H] 0.000 description 2
• 208000002491 severe combined immunodeficiency Diseases 0.000 description 2
• 229940121497 sintilimab Drugs 0.000 description 2
• 229950007213 spartalizumab Drugs 0.000 description 2
• 210000000130 stem cell Anatomy 0.000 description 2
• 238000012360 testing method Methods 0.000 description 2
• RWQNBRDOKXIBIV-UHFFFAOYSA-N thymine Chemical compound CC1=CNC(=O)NC1=O RWQNBRDOKXIBIV-UHFFFAOYSA-N 0.000 description 2
• 102000003298 tumor necrosis factor receptor Human genes 0.000 description 2
• OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 2
• 206010046766 uterine cancer Diseases 0.000 description 2
• 238000005406 washing Methods 0.000 description 2
• 229920003169 water-soluble polymer Polymers 0.000 description 2
• HDTRYLNUVZCQOY-UHFFFAOYSA-N &alpha;-D-glucopyranosyl-&alpha;-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 description 1
• KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 description 1
• HKZAAJSTFUZYTO-LURJTMIESA-N (2s)-2-[[2-[[2-[[2-[(2-aminoacetyl)amino]acetyl]amino]acetyl]amino]acetyl]amino]-3-hydroxypropanoic acid Chemical compound NCC(=O)NCC(=O)NCC(=O)NCC(=O)N[C@@H](CO)C(O)=O HKZAAJSTFUZYTO-LURJTMIESA-N 0.000 description 1
• 125000006624 (C1-C6) alkoxycarbonylamino group Chemical group 0.000 description 1
• 125000004738 (C1-C6) alkyl sulfinyl group Chemical group 0.000 description 1
• 125000004890 (C1-C6) alkylamino group Chemical group 0.000 description 1
• 125000003161 (C1-C6) alkylene group Chemical group 0.000 description 1
• 125000004739 (C1-C6) alkylsulfonyl group Chemical group 0.000 description 1
• 125000006700 (C1-C6) alkylthio group Chemical group 0.000 description 1
• 125000004737 (C1-C6) haloalkoxy group Chemical group 0.000 description 1
• WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 description 1
• FQERLIOIVXPZKH-UHFFFAOYSA-N 1,2,4-trioxane Chemical compound C1COOCO1 FQERLIOIVXPZKH-UHFFFAOYSA-N 0.000 description 1
• WNXJIVFYUVYPPR-UHFFFAOYSA-N 1,3-dioxolane Chemical compound C1COCO1 WNXJIVFYUVYPPR-UHFFFAOYSA-N 0.000 description 1
• 229940006190 2,3-dimercapto-1-propanesulfonic acid Drugs 0.000 description 1
• ZIIUUSVHCHPIQD-UHFFFAOYSA-N 2,4,6-trimethyl-N-[3-(trifluoromethyl)phenyl]benzenesulfonamide Chemical compound CC1=CC(C)=CC(C)=C1S(=O)(=O)NC1=CC=CC(C(F)(F)F)=C1 ZIIUUSVHCHPIQD-UHFFFAOYSA-N 0.000 description 1
• OLOMBAYFBVCLCE-UHFFFAOYSA-N 2-[1,2,5,11,14-pentakis(carboxymethyl)-1,2,5,8,11,14-hexazacyclohexadec-8-yl]acetic acid Chemical compound OC(=O)CN1CCN(CC(O)=O)CCN(CC(O)=O)CCN(CC(O)=O)N(CC(O)=O)CCN(CC(O)=O)CC1 OLOMBAYFBVCLCE-UHFFFAOYSA-N 0.000 description 1
• JHALWMSZGCVVEM-UHFFFAOYSA-N 2-[4,7-bis(carboxymethyl)-1,4,7-triazonan-1-yl]acetic acid Chemical compound OC(=O)CN1CCN(CC(O)=O)CCN(CC(O)=O)CC1 JHALWMSZGCVVEM-UHFFFAOYSA-N 0.000 description 1
• AETVBWZVKDOWHH-UHFFFAOYSA-N 2-[4-[2-(2,3-dihydro-1H-inden-2-ylamino)pyrimidin-5-yl]-3-(1-ethylazetidin-3-yl)oxypyrazol-1-yl]-1-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)ethanone Chemical compound C1C(CC2=CC=CC=C12)NC1=NC=C(C=N1)C=1C(=NN(C=1)CC(=O)N1CC2=C(CC1)NN=N2)OC1CN(C1)CC AETVBWZVKDOWHH-UHFFFAOYSA-N 0.000 description 1
• VNPMDUDIDCXVCH-UHFFFAOYSA-N 2-[4-[2-(2,3-dihydro-1H-inden-2-ylamino)pyrimidin-5-yl]-3-(3-piperazin-1-ylpropyl)pyrazol-1-yl]-1-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)ethanone Chemical compound O=C(CN1C=C(C(CCCN2CCNCC2)=N1)C1=CN=C(NC2CC3=C(C2)C=CC=C3)N=C1)N1CCC2=C(C1)N=NN2 VNPMDUDIDCXVCH-UHFFFAOYSA-N 0.000 description 1
• ZYPDJSJJXZWZJJ-UHFFFAOYSA-N 2-[4-[2-(2,3-dihydro-1H-inden-2-ylamino)pyrimidin-5-yl]-3-piperidin-4-yloxypyrazol-1-yl]-1-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)ethanone Chemical compound C1C(CC2=CC=CC=C12)NC1=NC=C(C=N1)C=1C(=NN(C=1)CC(=O)N1CC2=C(CC1)NN=N2)OC1CCNCC1 ZYPDJSJJXZWZJJ-UHFFFAOYSA-N 0.000 description 1
• DTRVZAALOQTDSF-UHFFFAOYSA-N 2-[[2-[bis(carboxymethyl)amino]-3-phenylpropyl]-(carboxymethyl)amino]acetic acid Chemical compound OC(=O)CN(CC(O)=O)CC(N(CC(O)=O)CC(O)=O)CC1=CC=CC=C1 DTRVZAALOQTDSF-UHFFFAOYSA-N 0.000 description 1
• BGFTWECWAICPDG-UHFFFAOYSA-N 2-[bis(4-chlorophenyl)methyl]-4-n-[3-[bis(4-chlorophenyl)methyl]-4-(dimethylamino)phenyl]-1-n,1-n-dimethylbenzene-1,4-diamine Chemical compound C1=C(C(C=2C=CC(Cl)=CC=2)C=2C=CC(Cl)=CC=2)C(N(C)C)=CC=C1NC(C=1)=CC=C(N(C)C)C=1C(C=1C=CC(Cl)=CC=1)C1=CC=C(Cl)C=C1 BGFTWECWAICPDG-UHFFFAOYSA-N 0.000 description 1
• XWSGEVNYFYKXCP-UHFFFAOYSA-N 2-[carboxymethyl(methyl)amino]acetic acid Chemical compound OC(=O)CN(C)CC(O)=O XWSGEVNYFYKXCP-UHFFFAOYSA-N 0.000 description 1
• BKKWZCSSYWYNDS-JEDNCBNOSA-N 2-aminoacetic acid;(2s)-2,6-diaminohexanoic acid Chemical group NCC(O)=O.NCCCC[C@H](N)C(O)=O BKKWZCSSYWYNDS-JEDNCBNOSA-N 0.000 description 1
• ASJSAQIRZKANQN-UHFFFAOYSA-N 2-deoxypentose Chemical compound OCC(O)C(O)CC=O ASJSAQIRZKANQN-UHFFFAOYSA-N 0.000 description 1
• LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 description 1
• UAIUNKRWKOVEES-UHFFFAOYSA-N 3,3',5,5'-tetramethylbenzidine Chemical compound CC1=C(N)C(C)=CC(C=2C=C(C)C(N)=C(C)C=2)=C1 UAIUNKRWKOVEES-UHFFFAOYSA-N 0.000 description 1
• LKKMLIBUAXYLOY-UHFFFAOYSA-N 3-Amino-1-methyl-5H-pyrido[4,3-b]indole Chemical compound N1C2=CC=CC=C2C2=C1C=C(N)N=C2C LKKMLIBUAXYLOY-UHFFFAOYSA-N 0.000 description 1
• KRGRJCUVPNQLTM-UHFFFAOYSA-N 5-chloro-2,3-dimethylpyrazolo[1,5-a]pyrimidin-7-amine Chemical compound NC1=CC(Cl)=NC2=C(C)C(C)=NN21 KRGRJCUVPNQLTM-UHFFFAOYSA-N 0.000 description 1
• HBBSDZXXUIHKJE-UHFFFAOYSA-N 6-hydrazinylpyridine-3-carboxylic acid Chemical compound NNC1=CC=C(C(O)=O)C=N1 HBBSDZXXUIHKJE-UHFFFAOYSA-N 0.000 description 1
• QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 description 1
• QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 1
• 229930024421 Adenine Natural products 0.000 description 1
• GFFGJBXGBJISGV-UHFFFAOYSA-N Adenine Chemical compound NC1=NC=NC2=C1N=CN2 GFFGJBXGBJISGV-UHFFFAOYSA-N 0.000 description 1
• 208000010507 Adenocarcinoma of Lung Diseases 0.000 description 1
• 102100034540 Adenomatous polyposis coli protein Human genes 0.000 description 1
• 230000007730 Akt signaling Effects 0.000 description 1
• 102100021266 Alpha-(1,6)-fucosyltransferase Human genes 0.000 description 1
• 101100279855 Arabidopsis thaliana EPFL5 gene Proteins 0.000 description 1
• 101100067974 Arabidopsis thaliana POP2 gene Proteins 0.000 description 1
• 101000878595 Arabidopsis thaliana Squalene synthase 1 Proteins 0.000 description 1
• DCXYFEDJOCDNAF-UHFFFAOYSA-N Asparagine Natural products OC(=O)C(N)CC(N)=O DCXYFEDJOCDNAF-UHFFFAOYSA-N 0.000 description 1
• 206010003571 Astrocytoma Diseases 0.000 description 1
• 108050001427 Avidin/streptavidin Proteins 0.000 description 1
• 108091008875 B cell receptors Proteins 0.000 description 1
• 102100029822 B- and T-lymphocyte attenuator Human genes 0.000 description 1
• 108010008014 B-Cell Maturation Antigen Proteins 0.000 description 1
• 102000006942 B-Cell Maturation Antigen Human genes 0.000 description 1
• 230000003844 B-cell-activation Effects 0.000 description 1
• 102100024222 B-lymphocyte antigen CD19 Human genes 0.000 description 1
• 206010005003 Bladder cancer Diseases 0.000 description 1
• 206010005949 Bone cancer Diseases 0.000 description 1
• 208000018084 Bone neoplasm Diseases 0.000 description 1
• 241000283690 Bos taurus Species 0.000 description 1
• 206010006143 Brain stem glioma Diseases 0.000 description 1
• 102100026094 C-type lectin domain family 12 member A Human genes 0.000 description 1
• 102100038078 CD276 antigen Human genes 0.000 description 1
• 101710185679 CD276 antigen Proteins 0.000 description 1
• 102100025221 CD70 antigen Human genes 0.000 description 1
• 101150031358 COLEC10 gene Proteins 0.000 description 1
• 108050007957 Cadherin Proteins 0.000 description 1
• 102000000905 Cadherin Human genes 0.000 description 1
• 241000282472 Canis lupus familiaris Species 0.000 description 1
• 241000283707 Capra Species 0.000 description 1
• 229920002134 Carboxymethyl cellulose Polymers 0.000 description 1
• 208000017897 Carcinoma of esophagus Diseases 0.000 description 1
• 108010078791 Carrier Proteins Proteins 0.000 description 1
• 102000000844 Cell Surface Receptors Human genes 0.000 description 1
• 108010001857 Cell Surface Receptors Proteins 0.000 description 1
• 241000282693 Cercopithecidae Species 0.000 description 1
• 206010008342 Cervix carcinoma Diseases 0.000 description 1
• 108010023736 Chondroitinases and Chondroitin Lyases Proteins 0.000 description 1
• KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 description 1
• 108020004705 Codon Proteins 0.000 description 1
• 206010010099 Combined immunodeficiency Diseases 0.000 description 1
• 102100032768 Complement receptor type 2 Human genes 0.000 description 1
• 102000004127 Cytokines Human genes 0.000 description 1
• 108090000695 Cytokines Proteins 0.000 description 1
• FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
• FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 1
• FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 1
• VVNCNSJFMMFHPL-VKHMYHEASA-N D-penicillamine Chemical compound CC(C)(S)[C@@H](N)C(O)=O VVNCNSJFMMFHPL-VKHMYHEASA-N 0.000 description 1
• HMFHBZSHGGEWLO-SOOFDHNKSA-N D-ribofuranose Chemical compound OC[C@H]1OC(O)[C@H](O)[C@@H]1O HMFHBZSHGGEWLO-SOOFDHNKSA-N 0.000 description 1
• 206010012735 Diarrhoea Diseases 0.000 description 1
• SHIBSTMRCDJXLN-UHFFFAOYSA-N Digoxigenin Natural products C1CC(C2C(C3(C)CCC(O)CC3CC2)CC2O)(O)C2(C)C1C1=CC(=O)OC1 SHIBSTMRCDJXLN-UHFFFAOYSA-N 0.000 description 1
• 108010016626 Dipeptides Proteins 0.000 description 1
• 206010061818 Disease progression Diseases 0.000 description 1
• 102100037024 E3 ubiquitin-protein ligase XIAP Human genes 0.000 description 1
• 102100038083 Endosialin Human genes 0.000 description 1
• 101710144543 Endosialin Proteins 0.000 description 1
• 206010014967 Ependymoma Diseases 0.000 description 1
• 108010055334 EphB2 Receptor Proteins 0.000 description 1
• 102000018651 Epithelial Cell Adhesion Molecule Human genes 0.000 description 1
• 108010066687 Epithelial Cell Adhesion Molecule Proteins 0.000 description 1
• 241000283086 Equidae Species 0.000 description 1
• CTKXFMQHOOWWEB-UHFFFAOYSA-N Ethylene oxide/propylene oxide copolymer Chemical compound CCCOC(C)COCCO CTKXFMQHOOWWEB-UHFFFAOYSA-N 0.000 description 1
• 208000006168 Ewing Sarcoma Diseases 0.000 description 1
• 241000282326 Felis catus Species 0.000 description 1
• LQEBEXMHBLQMDB-UHFFFAOYSA-N GDP-L-fucose Natural products OC1C(O)C(O)C(C)OC1OP(O)(=O)OP(O)(=O)OCC1C(O)C(O)C(N2C3=C(C(N=C(N)N3)=O)N=C2)O1 LQEBEXMHBLQMDB-UHFFFAOYSA-N 0.000 description 1
• LQEBEXMHBLQMDB-JGQUBWHWSA-N GDP-beta-L-fucose Chemical compound O[C@H]1[C@H](O)[C@H](O)[C@H](C)O[C@@H]1OP(O)(=O)OP(O)(=O)OC[C@@H]1[C@@H](O)[C@@H](O)[C@H](N2C3=C(C(NC(N)=N3)=O)N=C2)O1 LQEBEXMHBLQMDB-JGQUBWHWSA-N 0.000 description 1
• 102100031351 Galectin-9 Human genes 0.000 description 1
• 101100229077 Gallus gallus GAL9 gene Proteins 0.000 description 1
• 108010010803 Gelatin Proteins 0.000 description 1
• 201000010915 Glioblastoma multiforme Diseases 0.000 description 1
• WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
• 108050001154 Glypican Proteins 0.000 description 1
• 102000010956 Glypican Human genes 0.000 description 1
• 108050007237 Glypican-3 Proteins 0.000 description 1
• 108010090290 Growth Differentiation Factor 2 Proteins 0.000 description 1
• 102100034458 Hepatitis A virus cellular receptor 2 Human genes 0.000 description 1
• 208000021519 Hodgkin lymphoma Diseases 0.000 description 1
• 101000924577 Homo sapiens Adenomatous polyposis coli protein Proteins 0.000 description 1
• 101000690301 Homo sapiens Aldo-keto reductase family 1 member C4 Proteins 0.000 description 1
• 101000819490 Homo sapiens Alpha-(1,6)-fucosyltransferase Proteins 0.000 description 1
• 101000864344 Homo sapiens B- and T-lymphocyte attenuator Proteins 0.000 description 1
• 101000980825 Homo sapiens B-lymphocyte antigen CD19 Proteins 0.000 description 1
• 101100407305 Homo sapiens CD274 gene Proteins 0.000 description 1
• 101100059511 Homo sapiens CD40LG gene Proteins 0.000 description 1
• 101000934356 Homo sapiens CD70 antigen Proteins 0.000 description 1
• 101100496086 Homo sapiens CLEC12A gene Proteins 0.000 description 1
• 101000941929 Homo sapiens Complement receptor type 2 Proteins 0.000 description 1
• 101100118549 Homo sapiens EGFR gene Proteins 0.000 description 1
• 101000935587 Homo sapiens Flavin reductase (NADPH) Proteins 0.000 description 1
• 101000893585 Homo sapiens Growth/differentiation factor 2 Proteins 0.000 description 1
• 101001068133 Homo sapiens Hepatitis A virus cellular receptor 2 Proteins 0.000 description 1
• 101001041117 Homo sapiens Hyaluronidase PH-20 Proteins 0.000 description 1
• 101001103039 Homo sapiens Inactive tyrosine-protein kinase transmembrane receptor ROR1 Proteins 0.000 description 1
• 101001056180 Homo sapiens Induced myeloid leukemia cell differentiation protein Mcl-1 Proteins 0.000 description 1
• 101000878605 Homo sapiens Low affinity immunoglobulin epsilon Fc receptor Proteins 0.000 description 1
• 101001137987 Homo sapiens Lymphocyte activation gene 3 protein Proteins 0.000 description 1
• 101000577121 Homo sapiens Monocarboxylate transporter 3 Proteins 0.000 description 1
• 101001103036 Homo sapiens Nuclear receptor ROR-alpha Proteins 0.000 description 1
• 101001117312 Homo sapiens Programmed cell death 1 ligand 2 Proteins 0.000 description 1
• 101001116548 Homo sapiens Protein CBFA2T1 Proteins 0.000 description 1
• 101000777293 Homo sapiens Serine/threonine-protein kinase Chk1 Proteins 0.000 description 1
• 101000777277 Homo sapiens Serine/threonine-protein kinase Chk2 Proteins 0.000 description 1
• 101000874179 Homo sapiens Syndecan-1 Proteins 0.000 description 1
• 101000914514 Homo sapiens T-cell-specific surface glycoprotein CD28 Proteins 0.000 description 1
• 101000914484 Homo sapiens T-lymphocyte activation antigen CD80 Proteins 0.000 description 1
• 101000834948 Homo sapiens Tomoregulin-2 Proteins 0.000 description 1
• 101000904724 Homo sapiens Transmembrane glycoprotein NMB Proteins 0.000 description 1
• 101000611183 Homo sapiens Tumor necrosis factor Proteins 0.000 description 1
• 101000611185 Homo sapiens Tumor necrosis factor receptor superfamily member 5 Proteins 0.000 description 1
• 101000666896 Homo sapiens V-type immunoglobulin domain-containing suppressor of T-cell activation Proteins 0.000 description 1
• 108010003272 Hyaluronate lyase Proteins 0.000 description 1
• 102000001974 Hyaluronidases Human genes 0.000 description 1
• 108060006678 I-kappa-B kinase Proteins 0.000 description 1
• 102000001284 I-kappa-B kinase Human genes 0.000 description 1
• DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical class C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
• 102000018071 Immunoglobulin Fc Fragments Human genes 0.000 description 1
• 108010091135 Immunoglobulin Fc Fragments Proteins 0.000 description 1
• 102000013463 Immunoglobulin Light Chains Human genes 0.000 description 1
• 108010065825 Immunoglobulin Light Chains Proteins 0.000 description 1
• 102100039615 Inactive tyrosine-protein kinase transmembrane receptor ROR1 Human genes 0.000 description 1
• 102100026539 Induced myeloid leukemia cell differentiation protein Mcl-1 Human genes 0.000 description 1
• 108010064593 Intercellular Adhesion Molecule-1 Proteins 0.000 description 1
• 102100037877 Intercellular adhesion molecule 1 Human genes 0.000 description 1
• 238000012695 Interfacial polymerization Methods 0.000 description 1
• 108010002352 Interleukin-1 Proteins 0.000 description 1
• 108010065805 Interleukin-12 Proteins 0.000 description 1
• 108010038452 Interleukin-3 Receptors Proteins 0.000 description 1
• 102000010790 Interleukin-3 Receptors Human genes 0.000 description 1
• 108090001005 Interleukin-6 Proteins 0.000 description 1
• 108090001007 Interleukin-8 Proteins 0.000 description 1
• 102000015696 Interleukins Human genes 0.000 description 1
• 108010063738 Interleukins Proteins 0.000 description 1
• LPHGQDQBBGAPDZ-UHFFFAOYSA-N Isocaffeine Natural products CN1C(=O)N(C)C(=O)C2=C1N(C)C=N2 LPHGQDQBBGAPDZ-UHFFFAOYSA-N 0.000 description 1
• 102000002698 KIR Receptors Human genes 0.000 description 1
• 108010043610 KIR Receptors Proteins 0.000 description 1
• ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 description 1
• 102100031413 L-dopachrome tautomerase Human genes 0.000 description 1
• 101710093778 L-dopachrome tautomerase Proteins 0.000 description 1
• AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 description 1
• ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 description 1
• FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 description 1
• LRQKBLKVPFOOQJ-YFKPBYRVSA-N L-norleucine Chemical compound CCCC[C@H]([NH3+])C([O-])=O LRQKBLKVPFOOQJ-YFKPBYRVSA-N 0.000 description 1
• QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 description 1
• 125000000510 L-tryptophano group Chemical group [H]C1=C([H])C([H])=C2N([H])C([H])=C(C([H])([H])[C@@]([H])(C(O[H])=O)N([H])[*])C2=C1[H] 0.000 description 1
• KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 description 1
• 102000017578 LAG3 Human genes 0.000 description 1
• 102000004856 Lectins Human genes 0.000 description 1
• 108090001090 Lectins Proteins 0.000 description 1
• 206010024264 Lethargy Diseases 0.000 description 1
• ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 description 1
• 102100038007 Low affinity immunoglobulin epsilon Fc receptor Human genes 0.000 description 1
• 101710099301 Low affinity immunoglobulin gamma Fc region receptor III-A Proteins 0.000 description 1
• 208000028018 Lymphocytic leukaemia Diseases 0.000 description 1
• 102000043131 MHC class II family Human genes 0.000 description 1
• 108091054438 MHC class II family Proteins 0.000 description 1
• 239000012515 MabSelect SuRe Substances 0.000 description 1
• 239000004907 Macro-emulsion Substances 0.000 description 1
• 108700018351 Major Histocompatibility Complex Proteins 0.000 description 1
• 229930195725 Mannitol Natural products 0.000 description 1
• 208000000172 Medulloblastoma Diseases 0.000 description 1
• 102000051089 Melanotransferrin Human genes 0.000 description 1
• 108700038051 Melanotransferrin Proteins 0.000 description 1
• 108010061593 Member 14 Tumor Necrosis Factor Receptors Proteins 0.000 description 1
• 102000012750 Membrane Glycoproteins Human genes 0.000 description 1
• 108010090054 Membrane Glycoproteins Proteins 0.000 description 1
• 206010027476 Metastases Diseases 0.000 description 1
• 241001139947 Mida Species 0.000 description 1
• 102000004232 Mitogen-Activated Protein Kinase Kinases Human genes 0.000 description 1
• 102100025275 Monocarboxylate transporter 3 Human genes 0.000 description 1
• 108010008707 Mucin-1 Proteins 0.000 description 1
• 102000007298 Mucin-1 Human genes 0.000 description 1
• 102100034256 Mucin-1 Human genes 0.000 description 1
• 108010063954 Mucins Proteins 0.000 description 1
• 102000015728 Mucins Human genes 0.000 description 1
• 101100440312 Mus musculus C5 gene Proteins 0.000 description 1
• 101100273728 Mus musculus Cd33 gene Proteins 0.000 description 1
• 208000033776 Myeloid Acute Leukemia Diseases 0.000 description 1
• 208000014767 Myeloproliferative disease Diseases 0.000 description 1
• NQTADLQHYWFPDB-UHFFFAOYSA-N N-Hydroxysuccinimide Chemical compound ON1C(=O)CCC1=O NQTADLQHYWFPDB-UHFFFAOYSA-N 0.000 description 1
• OVRNDRQMDRJTHS-FMDGEEDCSA-N N-acetyl-beta-D-glucosamine Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O OVRNDRQMDRJTHS-FMDGEEDCSA-N 0.000 description 1
• 102100031688 N-acetylgalactosamine-6-sulfatase Human genes 0.000 description 1
• 108010069196 Neural Cell Adhesion Molecules Proteins 0.000 description 1
• 102000001068 Neural Cell Adhesion Molecules Human genes 0.000 description 1
• 208000015914 Non-Hodgkin lymphomas Diseases 0.000 description 1
• 206010030155 Oesophageal carcinoma Diseases 0.000 description 1
• 239000005642 Oleic acid Substances 0.000 description 1
• ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 description 1
• 108091034117 Oligonucleotide Proteins 0.000 description 1
• 239000012270 PD-1 inhibitor Substances 0.000 description 1
• 239000012668 PD-1-inhibitor Substances 0.000 description 1
• 229910019142 PO4 Inorganic materials 0.000 description 1
• 241000609499 Palicourea Species 0.000 description 1
• 208000000821 Parathyroid Neoplasms Diseases 0.000 description 1
• 241001494479 Pecora Species 0.000 description 1
• 208000002471 Penile Neoplasms Diseases 0.000 description 1
• 206010057249 Phagocytosis Diseases 0.000 description 1
• 102000015439 Phospholipases Human genes 0.000 description 1
• 108010064785 Phospholipases Proteins 0.000 description 1
• 102100021768 Phosphoserine aminotransferase Human genes 0.000 description 1
• 208000007913 Pituitary Neoplasms Diseases 0.000 description 1
• 201000005746 Pituitary adenoma Diseases 0.000 description 1
• 206010061538 Pituitary tumour benign Diseases 0.000 description 1
• 206010035226 Plasma cell myeloma Diseases 0.000 description 1
• 239000004743 Polypropylene Substances 0.000 description 1
• 239000004820 Pressure-sensitive adhesive Substances 0.000 description 1
• 241000932075 Priacanthus hamrur Species 0.000 description 1
• 102100024213 Programmed cell death 1 ligand 2 Human genes 0.000 description 1
• 101710089372 Programmed cell death protein 1 Proteins 0.000 description 1
• KDCGOANMDULRCW-UHFFFAOYSA-N Purine Natural products N1=CNC2=NC=NC2=C1 KDCGOANMDULRCW-UHFFFAOYSA-N 0.000 description 1
• CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical compound C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 description 1
• 101710100969 Receptor tyrosine-protein kinase erbB-3 Proteins 0.000 description 1
• 102100029986 Receptor tyrosine-protein kinase erbB-3 Human genes 0.000 description 1
• 108020004511 Recombinant DNA Proteins 0.000 description 1
• 208000015634 Rectal Neoplasms Diseases 0.000 description 1
• PYMYPHUHKUWMLA-LMVFSUKVSA-N Ribose Natural products OC[C@@H](O)[C@@H](O)[C@@H](O)C=O PYMYPHUHKUWMLA-LMVFSUKVSA-N 0.000 description 1
• 101000844752 Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) DNA-binding protein 7d Proteins 0.000 description 1
• 101100123851 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) HER1 gene Proteins 0.000 description 1
• 206010039491 Sarcoma Diseases 0.000 description 1
• 238000012300 Sequence Analysis Methods 0.000 description 1
• 102100031081 Serine/threonine-protein kinase Chk1 Human genes 0.000 description 1
• 102100031075 Serine/threonine-protein kinase Chk2 Human genes 0.000 description 1
• 108010071390 Serum Albumin Proteins 0.000 description 1
• 102000007562 Serum Albumin Human genes 0.000 description 1
• 108010029157 Sialic Acid Binding Ig-like Lectin 2 Proteins 0.000 description 1
• 108010029180 Sialic Acid Binding Ig-like Lectin 3 Proteins 0.000 description 1
• 208000000453 Skin Neoplasms Diseases 0.000 description 1
• VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 description 1
• 208000021712 Soft tissue sarcoma Diseases 0.000 description 1
• 229930006000 Sucrose Natural products 0.000 description 1
• CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
• 239000012505 Superdex™ Substances 0.000 description 1
• 102100035721 Syndecan-1 Human genes 0.000 description 1
• 230000006044 T cell activation Effects 0.000 description 1
• 102100027213 T-cell-specific surface glycoprotein CD28 Human genes 0.000 description 1
• 102100027222 T-lymphocyte activation antigen CD80 Human genes 0.000 description 1
• 108090000925 TNF receptor-associated factor 2 Proteins 0.000 description 1
• 102000004399 TNF receptor-associated factor 3 Human genes 0.000 description 1
• 108090000922 TNF receptor-associated factor 3 Proteins 0.000 description 1
• 102100034779 TRAF family member-associated NF-kappa-B activator Human genes 0.000 description 1
• WDLRUFUQRNWCPK-UHFFFAOYSA-N Tetraxetan Chemical compound OC(=O)CN1CCN(CC(O)=O)CCN(CC(O)=O)CCN(CC(O)=O)CC1 WDLRUFUQRNWCPK-UHFFFAOYSA-N 0.000 description 1
• 208000024770 Thyroid neoplasm Diseases 0.000 description 1
• 102100026160 Tomoregulin-2 Human genes 0.000 description 1
• 102100023935 Transmembrane glycoprotein NMB Human genes 0.000 description 1
• HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 description 1
• 101710190034 Trophoblast glycoprotein Proteins 0.000 description 1
• QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 description 1
• 102100040247 Tumor necrosis factor Human genes 0.000 description 1
• 102100028785 Tumor necrosis factor receptor superfamily member 14 Human genes 0.000 description 1
• 102100039094 Tyrosinase Human genes 0.000 description 1
• 108060008724 Tyrosinase Proteins 0.000 description 1
• 208000023915 Ureteral Neoplasms Diseases 0.000 description 1
• 206010046458 Urethral neoplasms Diseases 0.000 description 1
• 208000006105 Uterine Cervical Neoplasms Diseases 0.000 description 1
• 108010079206 V-Set Domain-Containing T-Cell Activation Inhibitor 1 Proteins 0.000 description 1
• 102100038929 V-set domain-containing T-cell activation inhibitor 1 Human genes 0.000 description 1
• 102100038282 V-type immunoglobulin domain-containing suppressor of T-cell activation Human genes 0.000 description 1
• 201000003761 Vaginal carcinoma Diseases 0.000 description 1
• KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 description 1
• 241000251539 Vertebrata <Metazoa> Species 0.000 description 1
• 102100038968 WAP four-disulfide core domain protein 1 Human genes 0.000 description 1
• 108700031544 X-Linked Inhibitor of Apoptosis Proteins 0.000 description 1
• QCWXUUIWCKQGHC-UHFFFAOYSA-N Zirconium Chemical compound [Zr] QCWXUUIWCKQGHC-UHFFFAOYSA-N 0.000 description 1
• 238000010521 absorption reaction Methods 0.000 description 1
• 230000001133 acceleration Effects 0.000 description 1
• 108010076089 accutase Proteins 0.000 description 1
• 239000008351 acetate buffer Substances 0.000 description 1
• 230000001154 acute effect Effects 0.000 description 1
• 208000012764 acute weight loss Diseases 0.000 description 1
• 229960000643 adenine Drugs 0.000 description 1
• 208000024447 adrenal gland neoplasm Diseases 0.000 description 1
• 230000002411 adverse Effects 0.000 description 1
• 238000001042 affinity chromatography Methods 0.000 description 1
• 125000003158 alcohol group Chemical group 0.000 description 1
• 125000003806 alkyl carbonyl amino group Chemical group 0.000 description 1
• HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 description 1
• HMFHBZSHGGEWLO-UHFFFAOYSA-N alpha-D-Furanose-Ribose Natural products OCC1OC(O)C(O)C1O HMFHBZSHGGEWLO-UHFFFAOYSA-N 0.000 description 1
• 125000003368 amide group Chemical group 0.000 description 1
• 125000003277 amino group Chemical group 0.000 description 1
• 238000010171 animal model Methods 0.000 description 1
• 230000002424 anti-apoptotic effect Effects 0.000 description 1
• 230000003302 anti-idiotype Effects 0.000 description 1
• 230000000692 anti-sense effect Effects 0.000 description 1
• 239000003963 antioxidant agent Substances 0.000 description 1
• 235000006708 antioxidants Nutrition 0.000 description 1
• 239000007864 aqueous solution Substances 0.000 description 1
• 229960005070 ascorbic acid Drugs 0.000 description 1
• 235000010323 ascorbic acid Nutrition 0.000 description 1
• 239000011668 ascorbic acid Substances 0.000 description 1
• 235000009582 asparagine Nutrition 0.000 description 1
• 229960001230 asparagine Drugs 0.000 description 1
• 125000000613 asparagine group Chemical group N[C@@H](CC(N)=O)C(=O)* 0.000 description 1
• 235000003704 aspartic acid Nutrition 0.000 description 1
• 229960003852 atezolizumab Drugs 0.000 description 1
• 125000004429 atom Chemical group 0.000 description 1
• 210000002469 basement membrane Anatomy 0.000 description 1
• 229960000686 benzalkonium chloride Drugs 0.000 description 1
• UHOVQNZJYSORNB-UHFFFAOYSA-N benzene Substances C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 1
• 229960001950 benzethonium chloride Drugs 0.000 description 1
• UREZNYTWGJKWBI-UHFFFAOYSA-M benzethonium chloride Chemical compound [Cl-].C1=CC(C(C)(C)CC(C)(C)C)=CC=C1OCCOCC[N+](C)(C)CC1=CC=CC=C1 UREZNYTWGJKWBI-UHFFFAOYSA-M 0.000 description 1
• 235000019445 benzyl alcohol Nutrition 0.000 description 1
• 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 description 1
• CADWTSSKOVRVJC-UHFFFAOYSA-N benzyl(dimethyl)azanium;chloride Chemical compound [Cl-].C[NH+](C)CC1=CC=CC=C1 CADWTSSKOVRVJC-UHFFFAOYSA-N 0.000 description 1
• WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
• SQVRNKJHWKZAKO-UHFFFAOYSA-N beta-N-Acetyl-D-neuraminic acid Natural products CC(=O)NC1C(O)CC(O)(C(O)=O)OC1C(O)C(O)CO SQVRNKJHWKZAKO-UHFFFAOYSA-N 0.000 description 1
• OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 description 1
• 201000009036 biliary tract cancer Diseases 0.000 description 1
• 208000020790 biliary tract neoplasm Diseases 0.000 description 1
• 238000013357 binding ELISA Methods 0.000 description 1
• 239000011230 binding agent Substances 0.000 description 1
• 230000029918 bioluminescence Effects 0.000 description 1
• 238000005415 bioluminescence Methods 0.000 description 1
• HUTDDBSSHVOYJR-UHFFFAOYSA-H bis[(2-oxo-1,3,2$l^{5},4$l^{2}-dioxaphosphaplumbetan-2-yl)oxy]lead Chemical compound [Pb+2].[Pb+2].[Pb+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O HUTDDBSSHVOYJR-UHFFFAOYSA-H 0.000 description 1
• JCXGWMGPZLAOME-UHFFFAOYSA-N bismuth atom Chemical compound [Bi] JCXGWMGPZLAOME-UHFFFAOYSA-N 0.000 description 1
• 230000000903 blocking effect Effects 0.000 description 1
• 230000037396 body weight Effects 0.000 description 1
• LRHPLDYGYMQRHN-UHFFFAOYSA-N butyl alcohol Substances CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 description 1
• 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
• ZTQSAGDEMFDKMZ-UHFFFAOYSA-N butyric aldehyde Natural products CCCC=O ZTQSAGDEMFDKMZ-UHFFFAOYSA-N 0.000 description 1
• 229960001948 caffeine Drugs 0.000 description 1
• VJEONQKOZGKCAK-UHFFFAOYSA-N caffeine Natural products CN1C(=O)N(C)C(=O)C2=C1C=CN2C VJEONQKOZGKCAK-UHFFFAOYSA-N 0.000 description 1
• 229910052791 calcium Inorganic materials 0.000 description 1
• 229950007712 camrelizumab Drugs 0.000 description 1
• 238000005251 capillar electrophoresis Methods 0.000 description 1
• 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 description 1
• 239000001768 carboxy methyl cellulose Substances 0.000 description 1
• 235000010948 carboxy methyl cellulose Nutrition 0.000 description 1
• 239000008112 carboxymethyl-cellulose Substances 0.000 description 1
• 239000006143 cell culture medium Substances 0.000 description 1
• 230000024245 cell differentiation Effects 0.000 description 1
• 230000004663 cell proliferation Effects 0.000 description 1
• 229940121420 cemiplimab Drugs 0.000 description 1
• 201000010881 cervical cancer Diseases 0.000 description 1
• 208000019065 cervical carcinoma Diseases 0.000 description 1
• 229910052729 chemical element Inorganic materials 0.000 description 1
• 238000007385 chemical modification Methods 0.000 description 1
• 208000032852 chronic lymphocytic leukemia Diseases 0.000 description 1
• 238000004140 cleaning Methods 0.000 description 1
• 238000003776 cleavage reaction Methods 0.000 description 1
• 230000004186 co-expression Effects 0.000 description 1
• 210000001072 colon Anatomy 0.000 description 1
• 238000011284 combination treatment Methods 0.000 description 1
• 238000012875 competitive assay Methods 0.000 description 1
• 230000024203 complement activation Effects 0.000 description 1
• 230000001268 conjugating effect Effects 0.000 description 1
• 238000004132 cross linking Methods 0.000 description 1
• 239000013078 crystal Substances 0.000 description 1
• 239000012228 culture supernatant Substances 0.000 description 1
• 208000030381 cutaneous melanoma Diseases 0.000 description 1
• IBAHLNWTOIHLKE-UHFFFAOYSA-N cyano cyanate Chemical compound N#COC#N IBAHLNWTOIHLKE-UHFFFAOYSA-N 0.000 description 1
• HPXRVTGHNJAIIH-UHFFFAOYSA-N cyclohexanol Chemical compound OC1CCCCC1 HPXRVTGHNJAIIH-UHFFFAOYSA-N 0.000 description 1
• XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 description 1
• 150000001945 cysteines Chemical class 0.000 description 1
• 229940104302 cytosine Drugs 0.000 description 1
• 239000002254 cytotoxic agent Substances 0.000 description 1
• 231100000599 cytotoxic agent Toxicity 0.000 description 1
• 229950007409 dacetuzumab Drugs 0.000 description 1
• 230000034994 death Effects 0.000 description 1
• 230000003247 decreasing effect Effects 0.000 description 1
• 230000002950 deficient Effects 0.000 description 1
• 239000003405 delayed action preparation Substances 0.000 description 1
• 239000000412 dendrimer Substances 0.000 description 1
• 229920000736 dendritic polymer Polymers 0.000 description 1
• 230000004069 differentiation Effects 0.000 description 1
• QONQRTHLHBTMGP-UHFFFAOYSA-N digitoxigenin Natural products CC12CCC(C3(CCC(O)CC3CC3)C)C3C11OC1CC2C1=CC(=O)OC1 QONQRTHLHBTMGP-UHFFFAOYSA-N 0.000 description 1
• SHIBSTMRCDJXLN-KCZCNTNESA-N digoxigenin Chemical compound C1([C@@H]2[C@@]3([C@@](CC2)(O)[C@H]2[C@@H]([C@@]4(C)CC[C@H](O)C[C@H]4CC2)C[C@H]3O)C)=CC(=O)OC1 SHIBSTMRCDJXLN-KCZCNTNESA-N 0.000 description 1
• 238000010790 dilution Methods 0.000 description 1
• 239000012895 dilution Substances 0.000 description 1
• 150000002016 disaccharides Chemical class 0.000 description 1
• 230000005750 disease progression Effects 0.000 description 1
• 239000002270 dispersing agent Substances 0.000 description 1
• 230000009429 distress Effects 0.000 description 1
• 125000002228 disulfide group Chemical group 0.000 description 1
• 230000003828 downregulation Effects 0.000 description 1
• 238000012377 drug delivery Methods 0.000 description 1
• 239000000975 dye Substances 0.000 description 1
• 238000002330 electrospray ionisation mass spectrometry Methods 0.000 description 1
• 230000008030 elimination Effects 0.000 description 1
• 238000003379 elimination reaction Methods 0.000 description 1
• 210000000750 endocrine system Anatomy 0.000 description 1
• 201000003914 endometrial carcinoma Diseases 0.000 description 1
• 201000004101 esophageal cancer Diseases 0.000 description 1
• 125000004185 ester group Chemical group 0.000 description 1
• 230000005284 excitation Effects 0.000 description 1
• 230000007717 exclusion Effects 0.000 description 1
• 230000001747 exhibiting effect Effects 0.000 description 1
• 239000013604 expression vector Substances 0.000 description 1
• 238000000605 extraction Methods 0.000 description 1
• 230000001605 fetal effect Effects 0.000 description 1
• 238000001914 filtration Methods 0.000 description 1
• IJJVMEJXYNJXOJ-UHFFFAOYSA-N fluquinconazole Chemical compound C=1C=C(Cl)C=C(Cl)C=1N1C(=O)C2=CC(F)=CC=C2N=C1N1C=NC=N1 IJJVMEJXYNJXOJ-UHFFFAOYSA-N 0.000 description 1
• 235000013305 food Nutrition 0.000 description 1
• 230000005714 functional activity Effects 0.000 description 1
• 108020001507 fusion proteins Proteins 0.000 description 1
• 102000037865 fusion proteins Human genes 0.000 description 1
• 229930182830 galactose Natural products 0.000 description 1
• 208000010749 gastric carcinoma Diseases 0.000 description 1
• 230000002496 gastric effect Effects 0.000 description 1
• 229920000159 gelatin Polymers 0.000 description 1
• 239000008273 gelatin Substances 0.000 description 1
• 235000019322 gelatine Nutrition 0.000 description 1
• 235000011852 gelatine desserts Nutrition 0.000 description 1
• 208000005017 glioblastoma Diseases 0.000 description 1
• 239000008103 glucose Substances 0.000 description 1
• 235000013922 glutamic acid Nutrition 0.000 description 1
• 239000004220 glutamic acid Substances 0.000 description 1
• 125000000291 glutamic acid group Chemical group N[C@@H](CCC(O)=O)C(=O)* 0.000 description 1
• ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 description 1
• 150000004676 glycans Chemical class 0.000 description 1
• PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
• 229910052737 gold Inorganic materials 0.000 description 1
• 239000010931 gold Substances 0.000 description 1
• 230000005484 gravity Effects 0.000 description 1
• 239000003102 growth factor Substances 0.000 description 1
• 229940093915 gynecological organic acid Drugs 0.000 description 1
• 230000003862 health status Effects 0.000 description 1
• 230000002489 hematologic effect Effects 0.000 description 1
• 208000019691 hematopoietic and lymphoid cell neoplasm Diseases 0.000 description 1
• 210000003958 hematopoietic stem cell Anatomy 0.000 description 1
• 206010073071 hepatocellular carcinoma Diseases 0.000 description 1
• 231100000844 hepatocellular carcinoma Toxicity 0.000 description 1
• 125000000623 heterocyclic group Chemical group 0.000 description 1
• 238000005734 heterodimerization reaction Methods 0.000 description 1
• 102000048362 human PDCD1 Human genes 0.000 description 1
• 102000054751 human RUNX1T1 Human genes 0.000 description 1
• 210000005260 human cell Anatomy 0.000 description 1
• 229920002674 hyaluronan Polymers 0.000 description 1
• 229960003160 hyaluronic acid Drugs 0.000 description 1
• 229960002773 hyaluronidase Drugs 0.000 description 1
• 210000004408 hybridoma Anatomy 0.000 description 1
• 125000001183 hydrocarbyl group Chemical group 0.000 description 1
• 230000002209 hydrophobic effect Effects 0.000 description 1
• 229920001600 hydrophobic polymer Polymers 0.000 description 1
• 229940044700 hylenex Drugs 0.000 description 1
• 230000008102 immune modulation Effects 0.000 description 1
• 230000036039 immunity Effects 0.000 description 1
• 230000003053 immunization Effects 0.000 description 1
• 238000002649 immunization Methods 0.000 description 1
• 229940127121 immunoconjugate Drugs 0.000 description 1
• 230000016784 immunoglobulin production Effects 0.000 description 1
• 238000000099 in vitro assay Methods 0.000 description 1
• 238000010832 independent-sample T-test Methods 0.000 description 1
• 230000001939 inductive effect Effects 0.000 description 1
• 230000036512 infertility Effects 0.000 description 1
• 239000004615 ingredient Substances 0.000 description 1
• 238000011081 inoculation Methods 0.000 description 1
• 230000005732 intercellular adhesion Effects 0.000 description 1
• 230000002452 interceptive effect Effects 0.000 description 1
• 238000001361 intraarterial administration Methods 0.000 description 1
• 238000007918 intramuscular administration Methods 0.000 description 1
• 238000010253 intravenous injection Methods 0.000 description 1
• 238000004255 ion exchange chromatography Methods 0.000 description 1
• PGHMRUGBZOYCAA-UHFFFAOYSA-N ionomycin Natural products O1C(CC(O)C(C)C(O)C(C)C=CCC(C)CC(C)C(O)=CC(=O)C(C)CC(C)CC(CCC(O)=O)C)CCC1(C)C1OC(C)(C(C)O)CC1 PGHMRUGBZOYCAA-UHFFFAOYSA-N 0.000 description 1
• PGHMRUGBZOYCAA-ADZNBVRBSA-N ionomycin Chemical compound O1[C@H](C[C@H](O)[C@H](C)[C@H](O)[C@H](C)/C=C/C[C@@H](C)C[C@@H](C)C(/O)=C/C(=O)[C@@H](C)C[C@@H](C)C[C@@H](CCC(O)=O)C)CC[C@@]1(C)[C@@H]1O[C@](C)([C@@H](C)O)CC1 PGHMRUGBZOYCAA-ADZNBVRBSA-N 0.000 description 1
• 229960005386 ipilimumab Drugs 0.000 description 1
• QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 description 1
• 150000002540 isothiocyanates Chemical class 0.000 description 1
• 229950000518 labetuzumab Drugs 0.000 description 1
• 239000002523 lectin Substances 0.000 description 1
• 238000012417 linear regression Methods 0.000 description 1
• 150000002632 lipids Chemical class 0.000 description 1
• 239000002502 liposome Substances 0.000 description 1
• 201000007270 liver cancer Diseases 0.000 description 1
• 208000014018 liver neoplasm Diseases 0.000 description 1
• 201000005249 lung adenocarcinoma Diseases 0.000 description 1
• OHSVLFRHMCKCQY-UHFFFAOYSA-N lutetium atom Chemical compound [Lu] OHSVLFRHMCKCQY-UHFFFAOYSA-N 0.000 description 1
• 208000003747 lymphoid leukemia Diseases 0.000 description 1
• 125000003588 lysine group Chemical group [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 description 1
• 230000002101 lytic effect Effects 0.000 description 1
• 208000026037 malignant tumor of neck Diseases 0.000 description 1
• 210000004962 mammalian cell Anatomy 0.000 description 1
• 239000000594 mannitol Substances 0.000 description 1
• 235000010355 mannitol Nutrition 0.000 description 1
• 239000000463 material Substances 0.000 description 1
• 108010082117 matrigel Proteins 0.000 description 1
• 239000002609 medium Substances 0.000 description 1
• 210000004379 membrane Anatomy 0.000 description 1
• 239000012528 membrane Substances 0.000 description 1
• 230000015654 memory Effects 0.000 description 1
• 206010027191 meningioma Diseases 0.000 description 1
• 230000009401 metastasis Effects 0.000 description 1
• 229930182817 methionine Natural products 0.000 description 1
• 125000001360 methionine group Chemical group N[C@@H](CCSC)C(=O)* 0.000 description 1
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
• 239000004292 methyl p-hydroxybenzoate Substances 0.000 description 1
• 235000010270 methyl p-hydroxybenzoate Nutrition 0.000 description 1
• 229960002216 methylparaben Drugs 0.000 description 1
• 239000004530 micro-emulsion Substances 0.000 description 1
• 239000004005 microsphere Substances 0.000 description 1
• 238000002156 mixing Methods 0.000 description 1
• 239000003607 modifier Substances 0.000 description 1
• 210000001616 monocyte Anatomy 0.000 description 1
• 239000000178 monomer Substances 0.000 description 1
• 150000002772 monosaccharides Chemical class 0.000 description 1
• 230000000921 morphogenic effect Effects 0.000 description 1
• 210000000066 myeloid cell Anatomy 0.000 description 1
• 201000000050 myeloid neoplasm Diseases 0.000 description 1
• HBAYEVATSBINBX-UHFFFAOYSA-N n-[5-[acetyl(hydroxy)amino]pentyl]-n'-hydroxy-n'-[5-[[4-[hydroxy-[5-[(4-isothiocyanatophenyl)carbamothioylamino]pentyl]amino]-4-oxobutanoyl]amino]pentyl]butanediamide Chemical compound CC(=O)N(O)CCCCCNC(=O)CCC(=O)N(O)CCCCCNC(=O)CCC(=O)N(O)CCCCCNC(=S)NC1=CC=C(N=C=S)C=C1 HBAYEVATSBINBX-UHFFFAOYSA-N 0.000 description 1
• 229950006780 n-acetylglucosamine Drugs 0.000 description 1
• 239000002088 nanocapsule Substances 0.000 description 1
• 239000002105 nanoparticle Substances 0.000 description 1
• 210000000822 natural killer cell Anatomy 0.000 description 1
• 208000007538 neurilemmoma Diseases 0.000 description 1
• MGFYIUFZLHCRTH-UHFFFAOYSA-N nitrilotriacetic acid Chemical compound OC(=O)CN(CC(O)=O)CC(O)=O MGFYIUFZLHCRTH-UHFFFAOYSA-N 0.000 description 1
• 229910052757 nitrogen Inorganic materials 0.000 description 1
• 239000002736 nonionic surfactant Substances 0.000 description 1
• 238000009206 nuclear medicine Methods 0.000 description 1
• ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 description 1
• 244000039328 opportunistic pathogen Species 0.000 description 1
• 150000007524 organic acids Chemical class 0.000 description 1
• 235000005985 organic acids Nutrition 0.000 description 1
• 230000002611 ovarian Effects 0.000 description 1
• 125000004043 oxo group Chemical group O=* 0.000 description 1
• LXCFILQKKLGQFO-UHFFFAOYSA-N p-hydroxybenzoic acid methyl ester Natural products COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 description 1
• 210000002990 parathyroid gland Anatomy 0.000 description 1
• 230000001575 pathological effect Effects 0.000 description 1
• 229940121655 pd-1 inhibitor Drugs 0.000 description 1
• 239000008188 pellet Substances 0.000 description 1
• 229960001639 penicillamine Drugs 0.000 description 1
• 230000007030 peptide scission Effects 0.000 description 1
• 238000010647 peptide synthesis reaction Methods 0.000 description 1
• 230000003094 perturbing effect Effects 0.000 description 1
• 230000008782 phagocytosis Effects 0.000 description 1
• 239000000546 pharmaceutical excipient Substances 0.000 description 1
• 230000003285 pharmacodynamic effect Effects 0.000 description 1
• COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 description 1
• NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
• 239000010452 phosphate Substances 0.000 description 1
• 208000021310 pituitary gland adenoma Diseases 0.000 description 1
• 210000005134 plasmacytoid dendritic cell Anatomy 0.000 description 1
• 229920001983 poloxamer Polymers 0.000 description 1
• 229920001993 poloxamer 188 Polymers 0.000 description 1
• 229940044519 poloxamer 188 Drugs 0.000 description 1
• 229920000191 poly(N-vinyl pyrrolidone) Polymers 0.000 description 1
• 229920001308 poly(aminoacid) Polymers 0.000 description 1
• 229920001583 poly(oxyethylated polyols) Polymers 0.000 description 1
• 108010054442 polyalanine Proteins 0.000 description 1
• 229920001281 polyalkylene Polymers 0.000 description 1
• 229920000193 polymethacrylate Polymers 0.000 description 1
• 102000040430 polynucleotide Human genes 0.000 description 1
• 108091033319 polynucleotide Proteins 0.000 description 1
• 239000002157 polynucleotide Substances 0.000 description 1
• 229920001155 polypropylene Polymers 0.000 description 1
• 229920001282 polysaccharide Polymers 0.000 description 1
• 239000005017 polysaccharide Substances 0.000 description 1
• 229920000136 polysorbate Polymers 0.000 description 1
• 229940068965 polysorbates Drugs 0.000 description 1
• 239000013641 positive control Substances 0.000 description 1
• 230000001323 posttranslational effect Effects 0.000 description 1
• 238000012545 processing Methods 0.000 description 1
• 239000000651 prodrug Substances 0.000 description 1
• 229940002612 prodrug Drugs 0.000 description 1
• 238000004393 prognosis Methods 0.000 description 1
• 230000000770 proinflammatory effect Effects 0.000 description 1
• 230000001902 propagating effect Effects 0.000 description 1
• 230000000069 prophylactic effect Effects 0.000 description 1
• 239000004405 propyl p-hydroxybenzoate Substances 0.000 description 1
• 235000010232 propyl p-hydroxybenzoate Nutrition 0.000 description 1
• 229960003415 propylparaben Drugs 0.000 description 1
• 210000002307 prostate Anatomy 0.000 description 1
• 238000000746 purification Methods 0.000 description 1
• IGFXRKMLLMBKSA-UHFFFAOYSA-N purine Chemical compound N1=C[N]C2=NC=NC2=C1 IGFXRKMLLMBKSA-UHFFFAOYSA-N 0.000 description 1
• 238000010791 quenching Methods 0.000 description 1
• 230000000171 quenching effect Effects 0.000 description 1
• 230000005855 radiation Effects 0.000 description 1
• 238000007420 radioactive assay Methods 0.000 description 1
• 229920005604 random copolymer Polymers 0.000 description 1
• 102000016914 ras Proteins Human genes 0.000 description 1
• 206010038038 rectal cancer Diseases 0.000 description 1
• 201000001275 rectum cancer Diseases 0.000 description 1
• 210000003289 regulatory T cell Anatomy 0.000 description 1
• 201000007444 renal pelvis carcinoma Diseases 0.000 description 1
• 238000004007 reversed phase HPLC Methods 0.000 description 1
• 229920006395 saturated elastomer Polymers 0.000 description 1
• 230000002000 scavenging effect Effects 0.000 description 1
• 206010039667 schwannoma Diseases 0.000 description 1
• 230000007017 scission Effects 0.000 description 1
• 238000012216 screening Methods 0.000 description 1
• 230000028327 secretion Effects 0.000 description 1
• 229940060040 selicrelumab Drugs 0.000 description 1
• 230000035945 sensitivity Effects 0.000 description 1
• SQVRNKJHWKZAKO-OQPLDHBCSA-N sialic acid Chemical compound CC(=O)N[C@@H]1[C@@H](O)C[C@@](O)(C(O)=O)OC1[C@H](O)[C@H](O)CO SQVRNKJHWKZAKO-OQPLDHBCSA-N 0.000 description 1
• 230000011664 signaling Effects 0.000 description 1
• 239000000377 silicon dioxide Substances 0.000 description 1
• 238000009097 single-agent therapy Methods 0.000 description 1
• 238000001542 size-exclusion chromatography Methods 0.000 description 1
• 201000000849 skin cancer Diseases 0.000 description 1
• 210000000813 small intestine Anatomy 0.000 description 1
• 229910052708 sodium Inorganic materials 0.000 description 1
• 239000011734 sodium Substances 0.000 description 1
• 239000001632 sodium acetate Substances 0.000 description 1
• 235000017281 sodium acetate Nutrition 0.000 description 1
• 229910000029 sodium carbonate Inorganic materials 0.000 description 1
• 238000002415 sodium dodecyl sulfate polyacrylamide gel electrophoresis Methods 0.000 description 1
• 239000002904 solvent Substances 0.000 description 1
• 230000000392 somatic effect Effects 0.000 description 1
• 239000000600 sorbitol Substances 0.000 description 1
• 206010041823 squamous cell carcinoma Diseases 0.000 description 1
• 239000003381 stabilizer Substances 0.000 description 1
• SFVFIFLLYFPGHH-UHFFFAOYSA-M stearalkonium chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCCCC[N+](C)(C)CC1=CC=CC=C1 SFVFIFLLYFPGHH-UHFFFAOYSA-M 0.000 description 1
• 238000011146 sterile filtration Methods 0.000 description 1
• 210000002784 stomach Anatomy 0.000 description 1
• 201000000498 stomach carcinoma Diseases 0.000 description 1
• 238000003860 storage Methods 0.000 description 1
• 238000010254 subcutaneous injection Methods 0.000 description 1
• 239000007929 subcutaneous injection Substances 0.000 description 1
• ACTRVOBWPAIOHC-UHFFFAOYSA-N succimer Chemical compound OC(=O)C(S)C(S)C(O)=O ACTRVOBWPAIOHC-UHFFFAOYSA-N 0.000 description 1
• ACTRVOBWPAIOHC-XIXRPRMCSA-N succimer Chemical compound OC(=O)[C@@H](S)[C@@H](S)C(O)=O ACTRVOBWPAIOHC-XIXRPRMCSA-N 0.000 description 1
• 239000005720 sucrose Substances 0.000 description 1
• 150000008163 sugars Chemical class 0.000 description 1
• 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 description 1
• 239000006228 supernatant Substances 0.000 description 1
• 230000020382 suppression by virus of host antigen processing and presentation of peptide antigen via MHC class I Effects 0.000 description 1
• 239000004094 surface-active agent Substances 0.000 description 1
• 238000013268 sustained release Methods 0.000 description 1
• 239000012730 sustained-release form Substances 0.000 description 1
• 208000024891 symptom Diseases 0.000 description 1
• 238000003786 synthesis reaction Methods 0.000 description 1
• 229940066453 tecentriq Drugs 0.000 description 1
• 229940124597 therapeutic agent Drugs 0.000 description 1
• 125000005300 thiocarboxy group Chemical group C(=S)(O)* 0.000 description 1
• 125000003396 thiol group Chemical group [H]S* 0.000 description 1
• 229940113082 thymine Drugs 0.000 description 1
• 210000001685 thyroid gland Anatomy 0.000 description 1
• 238000004448 titration Methods 0.000 description 1
• 230000000699 topical effect Effects 0.000 description 1
• 229940121514 toripalimab Drugs 0.000 description 1
• 231100000331 toxic Toxicity 0.000 description 1
• 231100000167 toxic agent Toxicity 0.000 description 1
• 230000002588 toxic effect Effects 0.000 description 1
• 239000003440 toxic substance Substances 0.000 description 1
• 238000010361 transduction Methods 0.000 description 1
• 230000026683 transduction Effects 0.000 description 1
• 239000012096 transfection reagent Substances 0.000 description 1
• 238000012546 transfer Methods 0.000 description 1
• 239000012581 transferrin Substances 0.000 description 1
• 238000003146 transient transfection Methods 0.000 description 1
• 229950007217 tremelimumab Drugs 0.000 description 1
• ILJSQTXMGCGYMG-UHFFFAOYSA-N triacetic acid Chemical compound CC(=O)CC(=O)CC(O)=O ILJSQTXMGCGYMG-UHFFFAOYSA-N 0.000 description 1
• 230000036326 tumor accumulation Effects 0.000 description 1
• 230000005909 tumor killing Effects 0.000 description 1
• 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 description 1
• 238000011144 upstream manufacturing Methods 0.000 description 1
• 229940035893 uracil Drugs 0.000 description 1
• 210000000626 ureter Anatomy 0.000 description 1
• 201000005112 urinary bladder cancer Diseases 0.000 description 1
• 239000004474 valine Substances 0.000 description 1
• 208000013013 vulvar carcinoma Diseases 0.000 description 1
• XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
• 208000016261 weight loss Diseases 0.000 description 1
• 238000001262 western blot Methods 0.000 description 1
• 229940055760 yervoy Drugs 0.000 description 1
• VWQVUPCCIRVNHF-UHFFFAOYSA-N yttrium atom Chemical compound [Y] VWQVUPCCIRVNHF-UHFFFAOYSA-N 0.000 description 1
• 229910052726 zirconium Inorganic materials 0.000 description 1