KR20230110515A - 눈 장애의 치료를 위한 화합물 및 방법 - Google Patents

눈 장애의 치료를 위한 화합물 및 방법 Download PDF

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Publication number
KR20230110515A
KR20230110515A KR1020237016470A KR20237016470A KR20230110515A KR 20230110515 A KR20230110515 A KR 20230110515A KR 1020237016470 A KR1020237016470 A KR 1020237016470A KR 20237016470 A KR20237016470 A KR 20237016470A KR 20230110515 A KR20230110515 A KR 20230110515A
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KR
South Korea
Prior art keywords
substituted
radical
alkyl
heteroalkyl
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
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KR1020237016470A
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English (en)
Korean (ko)
Inventor
이안 홈즈
야이르 알스터
힐라 바라쉬
찰스 보스워스
오메르 라파엘리
로버트 엠 버크
마크 글리슨
마크 리처드 스튜어트
조나단 던
알렉산더 제임스 니콜라스
Original Assignee
아주라 오프탈믹스 엘티디
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Publication date
Application filed by 아주라 오프탈믹스 엘티디 filed Critical 아주라 오프탈믹스 엘티디
Publication of KR20230110515A publication Critical patent/KR20230110515A/ko
Pending legal-status Critical Current

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042Compounds having saccharide radicals and heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0048Eye, e.g. artificial tears
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Ophthalmology & Optometry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
KR1020237016470A 2020-10-21 2021-10-20 눈 장애의 치료를 위한 화합물 및 방법 Pending KR20230110515A (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US202063094793P 2020-10-21 2020-10-21
US63/094,793 2020-10-21
US202163170988P 2021-04-05 2021-04-05
US63/170,988 2021-04-05
PCT/IB2021/000707 WO2022084738A2 (en) 2020-10-21 2021-10-20 Compounds and methods for the treatment of ocular disorders

Publications (1)

Publication Number Publication Date
KR20230110515A true KR20230110515A (ko) 2023-07-24

Family

ID=81291739

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020237016470A Pending KR20230110515A (ko) 2020-10-21 2021-10-20 눈 장애의 치료를 위한 화합물 및 방법

Country Status (8)

Country Link
EP (1) EP4232149A4 (https=)
JP (1) JP2023546453A (https=)
KR (1) KR20230110515A (https=)
AU (1) AU2021363702A1 (https=)
CA (1) CA3196145A1 (https=)
IL (1) IL302173A (https=)
MX (1) MX2023004537A (https=)
WO (1) WO2022084738A2 (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7700045B2 (ja) 2019-04-18 2025-06-30 アズーラ オフサルミックス エルティーディー. 眼障害を処置するための化合物および方法
US11459351B1 (en) 2021-04-05 2022-10-04 Azura Ophthalmics Ltd. Compounds and methods for the treatment of ocular disorders
WO2024100454A2 (en) * 2022-11-11 2024-05-16 Azura Ophthalmics Ltd. Composition and methods for improving signs and symptoms of ocular disorders

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1483579A4 (en) * 2002-02-15 2006-07-12 Merckle Gmbh CONJUGATES OF BIOLOGICALLY ACTIVE COMPOUNDS, PROCESS FOR THEIR MANUFACTURE AND USE, FORMULATION AND PHARMACEUTICAL APPLICATIONS THEREOF
CA2840626A1 (en) * 2011-06-29 2013-01-03 Insite Vision Incorporated Methods of treating recurrent meibomian glands disorder and thereby decreasing the frequency of recurrence
WO2018161039A1 (en) * 2017-03-03 2018-09-07 Synovo Gmbh Novel anti-infective and anti-inflammatory compounds
WO2018215638A1 (en) * 2017-05-26 2018-11-29 Novaliq Gmbh Pharmaceutical compositions comprising azithromycin
EP3955937A4 (en) * 2019-04-18 2023-01-18 Azura Ophthalmics Ltd. COMPOUNDS AND COMPOSITIONS FOR THE TREATMENT OF EYE DISEASES

Also Published As

Publication number Publication date
WO2022084738A2 (en) 2022-04-28
EP4232149A2 (en) 2023-08-30
EP4232149A4 (en) 2024-12-11
WO2022084738A3 (en) 2022-06-30
AU2021363702A1 (en) 2023-06-15
CA3196145A1 (en) 2022-04-28
JP2023546453A (ja) 2023-11-02
MX2023004537A (es) 2023-06-15
AU2021363702A9 (en) 2024-02-08
IL302173A (en) 2023-06-01

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Legal Events

Date Code Title Description
PA0105 International application

Patent event date: 20230515

Patent event code: PA01051R01D

Comment text: International Patent Application

PG1501 Laying open of application
A201 Request for examination
PA0201 Request for examination

Patent event code: PA02012R01D

Patent event date: 20241018

Comment text: Request for Examination of Application