JP2023546453A - 眼障害を処置するための化合物および方法 - Google Patents

眼障害を処置するための化合物および方法 Download PDF

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Publication number
JP2023546453A
JP2023546453A JP2023524276A JP2023524276A JP2023546453A JP 2023546453 A JP2023546453 A JP 2023546453A JP 2023524276 A JP2023524276 A JP 2023524276A JP 2023524276 A JP2023524276 A JP 2023524276A JP 2023546453 A JP2023546453 A JP 2023546453A
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JP
Japan
Prior art keywords
substituted
alkyl
radical
heteroalkyl
pharmaceutically acceptable
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
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JP2023524276A
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English (en)
Japanese (ja)
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JP2023546453A5 (https=
Inventor
ホームズ，イアン
アルスター，ヤイル
バラッシュ，ヒラ
ボスワース，チャールズ
ラファエリ，オマー
ブルク，ロバート，エム．
グリーソン，マルク
スチュワート，マーク，リチャード
ダン，ジョナサン
ニコラス，アレクサンダー，ジェームズ
Original Assignee
アズーラ オフサルミックス エルティーディー．
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Application filed by アズーラ オフサルミックス エルティーディー． filed Critical アズーラ オフサルミックス エルティーディー．
Publication of JP2023546453A publication Critical patent/JP2023546453A/ja
Publication of JP2023546453A5 publication Critical patent/JP2023546453A5/ja
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Ophthalmology & Optometry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP2023524276A 2020-10-21 2021-10-20 眼障害を処置するための化合物および方法 Pending JP2023546453A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US202063094793P 2020-10-21 2020-10-21
US63/094,793 2020-10-21
US202163170988P 2021-04-05 2021-04-05
US63/170,988 2021-04-05
PCT/IB2021/000707 WO2022084738A2 (en) 2020-10-21 2021-10-20 Compounds and methods for the treatment of ocular disorders

Publications (2)

Publication Number Publication Date
JP2023546453A true JP2023546453A (ja) 2023-11-02
JP2023546453A5 JP2023546453A5 (https=) 2024-10-29

Family

ID=81291739

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2023524276A Pending JP2023546453A (ja) 2020-10-21 2021-10-20 眼障害を処置するための化合物および方法

Country Status (8)

Country Link
EP (1) EP4232149A4 (https=)
JP (1) JP2023546453A (https=)
KR (1) KR20230110515A (https=)
AU (1) AU2021363702A1 (https=)
CA (1) CA3196145A1 (https=)
IL (1) IL302173A (https=)
MX (1) MX2023004537A (https=)
WO (1) WO2022084738A2 (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7700045B2 (ja) 2019-04-18 2025-06-30 アズーラ オフサルミックス エルティーディー． 眼障害を処置するための化合物および方法
US11459351B1 (en) 2021-04-05 2022-10-04 Azura Ophthalmics Ltd. Compounds and methods for the treatment of ocular disorders
WO2024100454A2 (en) * 2022-11-11 2024-05-16 Azura Ophthalmics Ltd. Composition and methods for improving signs and symptoms of ocular disorders

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018161039A1 (en) * 2017-03-03 2018-09-07 Synovo Gmbh Novel anti-infective and anti-inflammatory compounds
WO2020212760A2 (en) * 2019-04-18 2020-10-22 Azura Ophthalmics Ltd. Compounds and methods for the treatment of ocular disorders

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1483579A4 (en) * 2002-02-15 2006-07-12 Merckle Gmbh CONJUGATES OF BIOLOGICALLY ACTIVE COMPOUNDS, PROCESS FOR THEIR MANUFACTURE AND USE, FORMULATION AND PHARMACEUTICAL APPLICATIONS THEREOF
CA2840626A1 (en) * 2011-06-29 2013-01-03 Insite Vision Incorporated Methods of treating recurrent meibomian glands disorder and thereby decreasing the frequency of recurrence
WO2018215638A1 (en) * 2017-05-26 2018-11-29 Novaliq Gmbh Pharmaceutical compositions comprising azithromycin

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018161039A1 (en) * 2017-03-03 2018-09-07 Synovo Gmbh Novel anti-infective and anti-inflammatory compounds
WO2020212760A2 (en) * 2019-04-18 2020-10-22 Azura Ophthalmics Ltd. Compounds and methods for the treatment of ocular disorders

Also Published As

Publication number Publication date
WO2022084738A2 (en) 2022-04-28
EP4232149A2 (en) 2023-08-30
EP4232149A4 (en) 2024-12-11
WO2022084738A3 (en) 2022-06-30
AU2021363702A1 (en) 2023-06-15
CA3196145A1 (en) 2022-04-28
KR20230110515A (ko) 2023-07-24
MX2023004537A (es) 2023-06-15
AU2021363702A9 (en) 2024-02-08
IL302173A (en) 2023-06-01

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