KR20230105067A - Disinfectant composition with excellent sterilization power and sterilization rate - Google Patents
Disinfectant composition with excellent sterilization power and sterilization rate Download PDFInfo
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- 238000004659 sterilization and disinfection Methods 0.000 title claims abstract description 64
- 230000001954 sterilising effect Effects 0.000 title claims abstract description 58
- 239000000645 desinfectant Substances 0.000 title claims abstract description 49
- 239000000203 mixture Substances 0.000 title claims abstract description 42
- SMGTYJPMKXNQFY-UHFFFAOYSA-N octenidine dihydrochloride Chemical compound Cl.Cl.C1=CC(=NCCCCCCCC)C=CN1CCCCCCCCCCN1C=CC(=NCCCCCCCC)C=C1 SMGTYJPMKXNQFY-UHFFFAOYSA-N 0.000 claims abstract description 27
- 239000004094 surface-active agent Substances 0.000 claims abstract description 21
- 150000003863 ammonium salts Chemical class 0.000 claims abstract description 16
- 239000008213 purified water Substances 0.000 claims abstract description 8
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 8
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 claims description 14
- 125000000217 alkyl group Chemical group 0.000 claims description 7
- SYELZBGXAIXKHU-UHFFFAOYSA-N dodecyldimethylamine N-oxide Chemical compound CCCCCCCCCCCC[N+](C)(C)[O-] SYELZBGXAIXKHU-UHFFFAOYSA-N 0.000 claims description 6
- 229940048866 lauramine oxide Drugs 0.000 claims description 6
- ZRKZFNZPJKEWPC-UHFFFAOYSA-N decylamine-N,N-dimethyl-N-oxide Chemical compound CCCCCCCCCC[N+](C)(C)[O-] ZRKZFNZPJKEWPC-UHFFFAOYSA-N 0.000 claims description 5
- 238000000034 method Methods 0.000 claims description 3
- 239000006260 foam Substances 0.000 abstract description 10
- QCDWFXQBSFUVSP-UHFFFAOYSA-N 2-phenoxyethanol Chemical compound OCCOC1=CC=CC=C1 QCDWFXQBSFUVSP-UHFFFAOYSA-N 0.000 abstract description 8
- 229960005323 phenoxyethanol Drugs 0.000 abstract description 8
- 206010061924 Pulmonary toxicity Diseases 0.000 abstract description 7
- 231100000374 pneumotoxicity Toxicity 0.000 abstract description 7
- 208000035473 Communicable disease Diseases 0.000 abstract description 5
- 231100000167 toxic agent Toxicity 0.000 abstract description 5
- 239000003440 toxic substance Substances 0.000 abstract description 5
- 230000000813 microbial effect Effects 0.000 abstract description 3
- 230000007047 pulmonary toxicity Effects 0.000 abstract description 2
- 230000000694 effects Effects 0.000 description 9
- 244000005700 microbiome Species 0.000 description 8
- 241000894006 Bacteria Species 0.000 description 6
- 230000000052 comparative effect Effects 0.000 description 5
- 238000002474 experimental method Methods 0.000 description 4
- 229960001774 octenidine Drugs 0.000 description 4
- 206010059516 Skin toxicity Diseases 0.000 description 3
- 230000003115 biocidal effect Effects 0.000 description 3
- 201000010099 disease Diseases 0.000 description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
- 231100000438 skin toxicity Toxicity 0.000 description 3
- 238000005507 spraying Methods 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 239000003242 anti bacterial agent Substances 0.000 description 2
- 230000000844 anti-bacterial effect Effects 0.000 description 2
- 229940088710 antibiotic agent Drugs 0.000 description 2
- 230000001747 exhibiting effect Effects 0.000 description 2
- 208000015181 infectious disease Diseases 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 230000002906 microbiologic effect Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 230000000704 physical effect Effects 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- RXAPWIUBMWHNDN-UHFFFAOYSA-N 1-[1-(2h-pyridin-1-yl)decyl]-2h-pyridine Chemical class C1C=CC=CN1C(CCCCCCCCC)N1CC=CC=C1 RXAPWIUBMWHNDN-UHFFFAOYSA-N 0.000 description 1
- 208000035143 Bacterial infection Diseases 0.000 description 1
- 208000025721 COVID-19 Diseases 0.000 description 1
- 208000003322 Coinfection Diseases 0.000 description 1
- 208000007212 Foot-and-Mouth Disease Diseases 0.000 description 1
- 241000710198 Foot-and-mouth disease virus Species 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 1
- 208000002979 Influenza in Birds Diseases 0.000 description 1
- RJQXTJLFIWVMTO-TYNCELHUSA-N Methicillin Chemical compound COC1=CC=CC(OC)=C1C(=O)N[C@@H]1C(=O)N2[C@@H](C(O)=O)C(C)(C)S[C@@H]21 RJQXTJLFIWVMTO-TYNCELHUSA-N 0.000 description 1
- 208000025370 Middle East respiratory syndrome Diseases 0.000 description 1
- 229930182555 Penicillin Natural products 0.000 description 1
- JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 description 1
- 229920001213 Polysorbate 20 Polymers 0.000 description 1
- 241000191967 Staphylococcus aureus Species 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 229940121375 antifungal agent Drugs 0.000 description 1
- 239000003429 antifungal agent Substances 0.000 description 1
- 206010064097 avian influenza Diseases 0.000 description 1
- CADWTSSKOVRVJC-UHFFFAOYSA-N benzyl(dimethyl)azanium;chloride Chemical class [Cl-].C[NH+](C)CC1=CC=CC=C1 CADWTSSKOVRVJC-UHFFFAOYSA-N 0.000 description 1
- MRUAUOIMASANKQ-UHFFFAOYSA-N cocamidopropyl betaine Chemical compound CCCCCCCCCCCC(=O)NCCC[N+](C)(C)CC([O-])=O MRUAUOIMASANKQ-UHFFFAOYSA-N 0.000 description 1
- 229940073507 cocamidopropyl betaine Drugs 0.000 description 1
- 229960003085 meticillin Drugs 0.000 description 1
- DIOQZVSQGTUSAI-UHFFFAOYSA-N n-butylhexane Natural products CCCCCCCCCC DIOQZVSQGTUSAI-UHFFFAOYSA-N 0.000 description 1
- 229940049954 penicillin Drugs 0.000 description 1
- 230000002688 persistence Effects 0.000 description 1
- 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 description 1
- 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 description 1
- 229940068977 polysorbate 20 Drugs 0.000 description 1
- 208000023504 respiratory system disease Diseases 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 239000002888 zwitterionic surfactant Substances 0.000 description 1
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/34—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom
- A01N43/40—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom six-membered rings
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N33/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic nitrogen compounds
- A01N33/02—Amines; Quaternary ammonium compounds
- A01N33/12—Quaternary ammonium compounds
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Abstract
본 발명은 살균력과 살균속도가 우수한 소독제 조성물에 관한 것으로, 옥테니딘 염산염, 암모늄염, 계면활성제 및 정제수로 이루어진다.
상기의 성분으로 이루어지는 소독제 조성물은 독성 물질인 페녹시에탄올을 사용하지 않고도 우수한 살균력과 빠른 살균속도를 나타내기 때문에 감염병 예방에 특화되어 있을 뿐만 아니라, 표면소독용, 의료용 및 미생물 실험용 등 다양한 분야에서 활용될 수 있고 거품형태가 유지되어 낮은 폐독성을 나타낸다.The present invention relates to a disinfectant composition having excellent sterilization power and sterilization rate, and is composed of octenidine hydrochloride, ammonium salt, a surfactant and purified water.
Since the disinfectant composition composed of the above components exhibits excellent sterilization power and fast sterilization speed without using phenoxyethanol, which is a toxic substance, it is not only specialized in preventing infectious diseases, but also used in various fields such as surface disinfection, medical use, and microbial experimentation. and foam form is maintained to show low pulmonary toxicity.
Description
본 발명은 살균력과 살균속도가 우수한 소독제 조성물에 관한 것으로, 더욱 상세하게는 독성 물질인 페녹시에탄올을 사용하지 않고도 우수한 살균력과 빠른 살균속도를 나타내기 때문에 감염병 예방에 특화되어 있을 뿐만 아니라, 표면소독용, 의료용 및 미생물 실험용 등 다양한 분야에서 활용될 수 있고, 거품형태가 유지되어 낮은 폐독성을 나타내는 살균력과 살균속도가 우수한 소독제 조성물에 관한 것이다.The present invention relates to a disinfectant composition with excellent sterilization power and sterilization speed, and more particularly, because it exhibits excellent sterilization power and fast sterilization speed without using phenoxyethanol, which is a toxic substance, it is specialized in preventing infectious diseases, as well as surface disinfection It relates to a disinfectant composition that can be used in various fields such as for medical use, for microbiological experiments, etc., and has excellent sterilization power and sterilization rate, exhibiting low lung toxicity by maintaining a foam form.
최근, 각종 호흡기 질환(SARS 또는 MERS), 세균성 질환, 구제역 또는 조류인플루엔자 및 COVID-19 등과 같은 전염성이 강한 질병이 유행하여 이와 같은 질병에 대한 사람들의 우려가 증가하고 있으며, 상기한 질병을 유발하는 세균, 바이러스 및 곰팡이 등과 같은 미생물은 인류 건강을 위협하는 요인으로 작용하고 있다.Recently, various respiratory diseases (SARS or MERS), bacterial diseases, foot-and-mouth disease or highly contagious diseases such as avian influenza and COVID-19 are prevalent, and people's concerns about these diseases are increasing, and the causes of the above diseases Microorganisms such as bacteria, viruses and molds act as a factor threatening human health.
종래에 개발된 페니실린 등과 같은 항생제는 획기적인 의학적 성과로 인정되고 있으나, 이와 같은 항생제에 대한 내성을 보이는 미생물이 생성되면서 미생물에 대한 공포가 확산되고 있다. 특히, 병원 내 2차 감염을 유발하는 MRSA(메치실린 내성 황색포도상구균)와 같은 슈퍼박테리아는 큰 문제로 대두되고 있다.Conventionally developed antibiotics such as penicillin are recognized as innovative medical achievements, but as microorganisms resistant to such antibiotics are produced, fear of microorganisms is spreading. In particular, super bacteria such as MRSA (methicillin-resistant Staphylococcus aureus), which cause secondary infections in hospitals, are emerging as a major problem.
이에 따라, 살균제 또는 항진균제 등을 첨가한 소독제를 사용하여 미생물의 직·간접적인 감염을 최소화하고 있으나, 계면활성제를 이용한 소독제의 경우에는 유해 미생물을 완전히 제거하지 못하고, 단순히 소독을 목적으로 에탄올을 이용하는 경우에는 단시간 동안에는 유해 미생물을 제거할 수 있으나, 미미한 정도의 미생물을 제거할 뿐이고, 지속력이 낮아 미생물이 다시 증식하게 되어 주변 환경을 오염시키게 된다.Accordingly, direct or indirect infection of microorganisms is minimized by using a disinfectant to which a disinfectant or antifungal agent is added, but in the case of a disinfectant using a surfactant, it cannot completely remove harmful microorganisms, In this case, harmful microorganisms can be removed for a short time, but only a slight degree of microorganisms are removed, and the persistence is low, so the microorganisms proliferate again, contaminating the surrounding environment.
상기의 문제점을 해소하기 위해, 옥테니딘 성분이 함유된 소독제가 사용되고 있는데, 옥테니딘 성분을 단독으로 사용하는 경우에는 그람 음성균에 대하여 1분에서 5분 사이의 살균시간이 소요되는 문제점이 있었다.In order to solve the above problems, a disinfectant containing an octenidine component is used, but when the octenidine component is used alone, there is a problem in that sterilization time between 1 minute and 5 minutes is required for Gram-negative bacteria. .
또한, 살균시간을 줄이기 위해 옥테니딘 성분 외에 알코올류(페녹시에탄올)나 염화벤잘코늄류를 사용하는 경우 피부독성이 지나치게 증가하여 소독제 조성물의 적용분야가 지나치게 제한되는 문제점이 있었다.In addition, when alcohols (phenoxyethanol) or benzalkonium chlorides are used in addition to the octenidine component to reduce the sterilization time, there is a problem that the application field of the disinfectant composition is excessively limited due to excessive increase in skin toxicity.
본 발명의 목적은 독성 물질인 페녹시에탄올을 사용하지 않고도 우수한 살균력과 빠른 살균속도를 나타내기 때문에 감염병 예방에 특화되어 있을 뿐만 아니라, 표면소독용, 의료용 및 미생물 실험용 등 다양한 분야에서 활용될 수 있고, 거품형태가 유지되어 낮은 폐독성을 나타내는 살균력과 살균속도가 우수한 소독제 조성물을 제공하는 것이다.The object of the present invention is not only specialized in preventing infectious diseases because it exhibits excellent sterilization power and fast sterilization speed without using toxic substance phenoxyethanol, but can also be used in various fields such as surface disinfection, medical and microbial experiments, , To provide a disinfectant composition with excellent sterilization power and sterilization rate showing low pulmonary toxicity by maintaining a foam form.
본 발명의 목적은 옥테니딘 염산염, 암모늄염, 계면활성제 및 정제수로 이루어지는 것을 특징으로 하는 살균력과 살균속도가 우수한 소독제 조성물을 제공함에 의해 달성된다.An object of the present invention is achieved by providing a disinfectant composition having excellent sterilization power and sterilization rate, characterized in that it consists of octenidine hydrochloride, ammonium salt, surfactant and purified water.
본 발명의 바람직한 특징에 따르면, 상기 살균력과 살균속도가 우수한 소독제 조성물은 옥테니딘 염산염 0.01 내지 5 중량%, 암모늄염 0.01 내지 0.2 중량%, 계면활성제 0.1 내지 10 중량% 및 정제수 잔량으로 이루어지는 것으로 한다.According to a preferred feature of the present invention, the disinfectant composition having excellent sterilization power and sterilization rate is composed of 0.01 to 5% by weight of octenidine hydrochloride, 0.01 to 0.2% by weight of ammonium salt, 0.1 to 10% by weight of surfactant, and the remaining amount of purified water.
본 발명의 더 바람직한 특징에 따르면, 상기 옥테니딘 염산염은 옥테니딘디히드로클로라이드로 이루어지는 것으로 한다.According to a more preferred feature of the present invention, the octenidine hydrochloride is composed of octenidine dihydrochloride.
본 발명의 더욱 바람직한 특징에 따르면, 상기 암모늄염은 디알킬디메틸암모늄클로라이드, 디옥틸알킬디메틸암모늄클로라이드,디데실알킬디메틸암모늄클로라이드 및 옥틸데실알킬암모늄클로라이드로 이루어진 그룹에서 선택된 하나 이상으로 이루어지는 것으로 한다.According to a more preferred feature of the present invention, the ammonium salt is composed of at least one selected from the group consisting of dialkyldimethylammonium chloride, dioctylalkyldimethylammonium chloride, didecylalkyldimethylammonium chloride and octyldecylalkylammonium chloride.
본 발명의 더욱 더 바람직한 특징에 따르면, 상기 계면활성제는 알킬옥사이드로 이루어지는 것으로 한다.According to a more preferred feature of the present invention, the surfactant is made of an alkyl oxide.
본 발명의 더욱 더 바람직한 특징에 따르면, 상기 알킬옥사이드는 데실아민옥사이드 및 라우라민옥사이드로 이루어진 그룹에서 선택된 하나 이상으로 이루어지는 것으로 한다.According to a more preferred feature of the present invention, the alkyl oxide is made of at least one selected from the group consisting of decylamine oxide and lauramine oxide.
본 발명에 따른 살균력과 살균속도가 우수한 소독제 조성물은 독성 물질인 페녹시에탄올을 사용하지 않고도 우수한 살균력과 빠른 살균속도를 나타내기 때문에 감염병 예방에 특화되어 있을 뿐만 아니라, 표면소독용, 의료용 및 미생물 실험용 등 다양한 분야에서 활용될 수 있고, 거품형태가 유지되어 낮은 폐독성을 나타내는 소독제 조성물을 제공하는 탁월한 효과를 나타낸다.Since the disinfectant composition with excellent sterilization power and sterilization speed according to the present invention shows excellent sterilization power and fast sterilization speed without using phenoxyethanol, which is a toxic substance, it is not only specialized for preventing infectious diseases, but also for surface disinfection, medical use, and microbiological experiments. It can be used in various fields such as, and exhibits an excellent effect of providing a disinfectant composition that maintains a foam form and exhibits low lung toxicity.
도 1은 본 발명의 실시예 1 및 비교예 1 내지 2를 통해 제조된 소독제 조성물로 제조된 거품의 외관을 촬영하여 나타낸 사진이다.
도 2 내지 5는 본 발명의 실시예 1을 통해 제조된 살균력과 살균속도가 우수한 소독제 조성물의 살균력 시험 결과를 촬영하여 나타낸 사진이다.1 is a photograph showing the appearance of foam prepared from a disinfectant composition prepared in Example 1 and Comparative Examples 1 and 2 of the present invention.
2 to 5 are photographs showing the sterilization test results of the disinfectant composition having excellent sterilization power and sterilization rate prepared in Example 1 of the present invention.
이하에는, 본 발명의 바람직한 실시예와 각 성분의 물성을 상세하게 설명하되, 이는 본 발명이 속하는 기술분야에서 통상의 지식을 가진 자가 발명을 용이하게 실시할 수 있을 정도로 상세하게 설명하기 위한 것이지, 이로 인해 본 발명의 기술적인 사상 및 범주가 한정되는 것을 의미하지는 않는다.Hereinafter, a preferred embodiment of the present invention and the physical properties of each component will be described in detail, but this is to be explained in detail so that a person having ordinary knowledge in the art to which the present invention belongs can easily practice the invention, This is not meant to limit the technical spirit and scope of the present invention.
본 발명에 따른 살균력과 살균속도가 우수한 소독제 조성물은 옥테니딘 염산염, 암모늄염, 계면활성제 및 정제수로 이루어지며, 옥테니딘 염산염 0.01 내지 5 중량%, 암모늄염 0.01 내지 0.2 중량%, 계면활성제 0.1 내지 10 중량% 및 정제수 잔량으로 이루어지는 것이 바람직하다.The disinfectant composition having excellent sterilization power and sterilization rate according to the present invention is composed of octenidine hydrochloride, ammonium salt, surfactant and purified water, 0.01 to 5% by weight of octenidine hydrochloride, 0.01 to 0.2% by weight of ammonium salt, 0.1 to 10% surfactant It is preferably composed of weight% and the remaining amount of purified water.
상기 옥테니딘 염산염은 0.01 내지 5 중량%가 함유되는데, 양성이온 표면활성제이기도 하며 화학구조상 비스-(디하아드로피리디닐)-데칸[bis-(dihydropyridinyl)-decane]유도체의 일종으로서 탄소 10개를 함유한 데칸 알킬의 양 측쇄부분에 옥틸아미노피리딘(Octylaminopyridine) 유도체를 동시에 가지는 양쪽 체인을 가진 매우 긴 고리 라인상 계면 활성제인 동시에 강력한 살균 소독력을 나타낸다.The octenidine hydrochloride contains 0.01 to 5% by weight, which is also a zwitterionic surfactant and has 10 carbons as a kind of bis-(dihydropyridinyl)-decane derivative in terms of chemical structure It is a very long chain line surfactant with both sides of octylaminopyridine derivatives on both side chains of decane alkyl containing
또한, 옥테니딘 염산염은 안전성이 확보된 살균 소독제로 사용되며, 타 살균제보다 강력한 활성이 있다. 이때, 상기 옥테니딘 염산염은 옥테니딘디히드로클로라이드로 이루어지는 것이 바람직하다.In addition, octenidine hydrochloride is used as a safe disinfectant and has a stronger activity than other disinfectants. At this time, the octenidine hydrochloride is preferably composed of octenidine dihydrochloride.
상기 옥테니딘 염산염의 함량이 0.01 중량% 미만이면 본 발명에 따른 소독제 조성물의 살균력이 저하되며, 상기 옥테니딘 염산염의 함량이 5 중량%를 초과하게되면 상가의 효과는 크게 향상되지 않으면서 피부독성이 증가된다.If the content of the octenidine hydrochloride is less than 0.01% by weight, the bactericidal power of the disinfectant composition according to the present invention is reduced, and if the content of the octenidine hydrochloride exceeds 5% by weight, the effect of the octenidine hydrochloride is not greatly improved and the skin toxicity is increased.
본 발명에서 사용되는 옥테니딘 염산염인 옥테니딘디히드로클로라이드를 아래 구조식 1에 나타내었다.Octenidine dihydrochloride, which is octenidine hydrochloride used in the present invention, is shown in Structural Formula 1 below.
<구조식 1><Structural Formula 1>
상기 암모늄염은 0.01 내지 0.2 중량%가 함유되며, 디알킬디메틸암모늄클로라이드, 디옥틸알킬디메틸암모늄클로라이드,디데실알킬디메틸암모늄클로라이드 및 옥틸데실알킬암모늄클로라이드로 이루어진 그룹에서 선택된 하나 이상으로 이루어지는데, 본 발명에 따른 살균제 조성물에 페녹시에탄올과 같은 알코올 성분을 혼합하지 않고도 살균속도가 향상될 수 있도록 하는 역할을 한다.The ammonium salt contains 0.01 to 0.2% by weight and is composed of at least one selected from the group consisting of dialkyldimethylammonium chloride, dioctylalkyldimethylammonium chloride, didecylalkyldimethylammonium chloride and octyldecylalkylammonium chloride, the present invention It serves to improve the sterilization rate without mixing alcohol components such as phenoxyethanol in the disinfectant composition according to.
상기 암모늄염의 함량이 0.01 중량% 미만이면 상기의 효과가 미미하며, 상기 암모늄염의 함량이 0.2 중량%를 초과하게 되면 피부독성이 증가할 뿐만 아니라 상기의 효과는 크게 향상되지 않으면서 상대적으로 옥테니딘 염산염이나 계면활성제의 함량이 지나치게 줄어들기 때문에 바람지하지 못하다.If the content of the ammonium salt is less than 0.01% by weight, the effect is insignificant, and if the content of the ammonium salt exceeds 0.2% by weight, not only skin toxicity increases, but also relatively octenidine without significantly improving the effect. This is undesirable because the content of hydrochloride or surfactant is excessively reduced.
상기 암모늄염으로 사용되는 성분 중 디알킬디메틸암모늄클로라이드를 아래 구조식 2에 나타내었다.Of the components used as the ammonium salt, dialkyldimethylammonium chloride is shown in Structural Formula 2 below.
<구조식 2><Structural Formula 2>
상기 계면활성제는 0.1 내지 10 중량% 가 함유되며, 본 발명에 따른 살균제 조성물에 페녹시에탄올과 같은 알코올 성분을 혼합하지 않고도 살균력과 살균속도가 향상될 수 있도록 할 뿐만 아니라, 본 발명에 따른 소독제 조성물이 안정적인 기포를 형성하도록 하는 역할을 한다.The surfactant is contained in an amount of 0.1 to 10% by weight, and sterilization power and sterilization rate can be improved without mixing alcohol components such as phenoxyethanol in the disinfectant composition according to the present invention, and the disinfectant composition according to the present invention It plays a role in forming this stable bubble.
이때, 상기 계면활성제는 알킬옥사이드로 이루어지는 것이 바람직하며, 상기 알킬옥사이드는 데실아민옥사이드 및 라우라민옥사이드로 이루어진 그룹에서 선택된 하나 이상으로 이루어지는 것이 더욱 바람직하다.In this case, the surfactant is preferably composed of an alkyl oxide, and the alkyl oxide is more preferably composed of at least one selected from the group consisting of decylamine oxide and lauramine oxide.
상기와 같이 알킬옥사이드인 데실아민옥사이드나 라우라민옥사이드를 계면활성제로 사용하여 제조되는 소독제는 공기중으로 뿌려짐 없이 안적적인 기포를 형성하여 폼의 형태를 제공한다.As described above, the disinfectant prepared by using decylamine oxide or lauramine oxide, which are alkyl oxides, as a surfactant provides a form of foam by forming stable bubbles without being sprayed into the air.
상기 암모늄염으로 사용되는 성분의 경우 폐독성이 존재하기 때문에, 뿌려짐 현상이 없는 폼의 형태로 적용되는 것이 바람직한데, 상기와 같이 데실아민옥사이드나 라우라민옥사이드를 계면활성제로 사용한 경우 안정적인 기포를 형성하여 뿌려짐 현상이 없이 폼의 형태를 유지하기 때문에 폐독성이 낮은 소독제 조성물이 제공될 수 있다.Since the component used as the ammonium salt has lung toxicity, it is preferable to apply it in the form of a foam without splashing. As described above, when decylamine oxide or lauramine oxide is used as a surfactant, stable bubbles are formed Since it maintains the form of a foam without a spraying phenomenon, a disinfectant composition with low lung toxicity can be provided.
상기 계면활성제의 함량이 0.1 중량% 미만이면 상기의 효과가 미미하며, 상기 계면활성제의 함량이 10 중량%를 초과하게 되면 상기의 효과는 크게 향상되지 않으면서 상대적으로 옥테니딘 염산염과 암모늄염의 함량이 지나치게 줄어들기 때문에 바람직하지 못하다.If the content of the surfactant is less than 0.1% by weight, the effect is insignificant, and if the content of the surfactant exceeds 10% by weight, the effect is not greatly improved, and the content of octenidine hydrochloride and ammonium salt is relatively This is undesirable because it reduces too much.
이하에서는, 본 발명에 따른 살균력과 살균속도가 우수한 소독제 조성물의 제조방법 및 그 제조방법으로 제조된 소독제 조성물의 물성을 실시예를 들어 설명하기로 한다.Hereinafter, the manufacturing method of the disinfectant composition having excellent sterilization power and sterilization rate according to the present invention and the physical properties of the disinfectant composition prepared by the manufacturing method will be described with examples.
<실시예 1><Example 1>
옥테니딘 염산염(옥테니딘디히드로클로라이드) 0.1 중량%, 암모늄염(디알킬디메틸암모늄클로라이드) 0.2 중량%, 계면활성제(라우라민옥사이드, 미원화학 MINOX L) 0.3 중량% 및 정제수 잔량을 교반기가 구비된 혼합장치에 투입하고 150rpm의 속도로 10분 동안 교반하여 살균력과 살균속도가 우수한 소독제 조성물을 제조하였다.Octenidine hydrochloride (octenidine dihydrochloride) 0.1% by weight, ammonium salt (dialkyldimethylammonium chloride) 0.2% by weight, surfactant (lauramine oxide, Miwon Chemical MINOX L) 0.3% by weight and the remaining amount of purified water were mixed with a stirrer It was put into a mixing device and stirred at a speed of 150 rpm for 10 minutes to prepare a disinfectant composition having excellent sterilization power and sterilization rate.
<비교예 1><Comparative Example 1>
상기 실시예 1과 동일하게 진행하되, 계면활성제로 코카미도프로필 베타인을 사용하여 소독제 조성물을 제조하였다.A disinfectant composition was prepared in the same manner as in Example 1, but using cocamidopropyl betaine as a surfactant.
<비교예 2><Comparative Example 2>
상기 실시예 1과 동일하게 진행하되, 계면활성제로 폴리솔베이트20을 사용하여 소독제 조성물을 제조하였다.A disinfectant composition was prepared in the same manner as in Example 1, but using polysorbate 20 as a surfactant.
상기 실시예 1 및 비교예 1 내지 2를 통해 제조된 소독제 조성물의 외관을 촬영하여 아래 도 1에 나타내었다.The exterior of the disinfectant composition prepared in Example 1 and Comparative Examples 1 and 2 was photographed and shown in FIG. 1 below.
{단, 소독제 조성물의 외관은 제조된 소독제 조성물을 스프레이 용기에 투입하고 분무한 후에 모습을 촬영하는 방법을 이용하였다.}{However, for the appearance of the disinfectant composition, a method of photographing the appearance after putting the prepared disinfectant composition into a spray container and spraying was used.}
아래 도 1에 나타낸 것처럼, 본 발명의 실시예 1을 통해 제조된 소독제 조성물은 거품이 안정적으로 형성된 반면, 비교예 1 내지 2를 통해 제조된 소독제 조성물은 뿌려짐 현상이 나타나는 것을 알 수 있다.As shown in Figure 1 below, it can be seen that the disinfectant composition prepared through Example 1 of the present invention has a stable foam, whereas the disinfectant composition prepared through Comparative Examples 1 and 2 shows a spraying phenomenon.
또한, 상기 실시예 1을 통해 제조된 소독제 조성물의 살균력을 측정하여 아래 표 1 및 도 2 내지 5에 나타내었다.In addition, the bactericidal power of the disinfectant composition prepared in Example 1 was measured and shown in Table 1 and FIGS. 2 to 5 below.
<표 1> 살균력 시험(ASTM E2315-16, TIME KILL TEST)<Table 1> Sterilization test (ASTM E2315-16, TIME KILL TEST)
상기 표 1 및 아래 도 2 내지 5에 나타낸 것처럼, 본 발명의 실시예 1을 통해 제조된 살균제 조성물은 우수한 살균효과를 나타내며, 특히 접촉시간이 15초인 조건에서도 우수한 살균효과를 나타내는 것을 알 수 있다.As shown in Table 1 and FIGS. 2 to 5 below, it can be seen that the disinfectant composition prepared in Example 1 of the present invention exhibits excellent sterilization effect, especially even under the condition that the contact time is 15 seconds.
또한, 상기 실시예 1을 통해 제조된 소독제 조성물의 항생제 내성균에 관한 테스트를 실시하여 그 결과를 아래 표 2에 나타내었다.In addition, a test was conducted on antibiotic-resistant bacteria of the disinfectant composition prepared in Example 1, and the results are shown in Table 2 below.
<표 2><Table 2>
상기 표 2에 나타낸 것처럼, 30초 및 1분 후의 log reduction 값은 MRSA에 대하여 > 5.67, VRE에 대하여 > 5.89로 나타났다. 일반적으로 병원에서 가장 문제가 되는 항생제 내성균에 관하여 5Log이상 빠르게 소독할 수 있는 것을 알 수 있으며, 상기의 소독효과를 나타내는 소독제 조성물은 항생제 내성균 감염관리에 매우 유용하게 사용될 수 있다.As shown in Table 2 above, the log reduction values after 30 seconds and 1 minute were > 5.67 for MRSA and > 5.89 for VRE. In general, it can be seen that antibiotic-resistant bacteria, which are the most problematic in hospitals, can be disinfected quickly by 5 Log or more, and the disinfectant composition exhibiting the above disinfection effect can be very useful for infection control of antibiotic-resistant bacteria.
따라서, 본 발명에 따른 살균력과 살균속도가 우수한 소독제 조성물은 독성 물질인 페녹시에탄올을 사용하지 않고도 우수한 살균력과 빠른 살균속도를 나타내기 때문에 감염병 예방에 특화되어 있을 뿐만 아니라, 표면소독용, 의료용 및 미생물 실험용 등 다양한 분야에서 활용될 수 있고, 거품형태가 유지되어 낮은 폐독성을 나타내는 소독제 조성물을 제공한다.Therefore, since the disinfectant composition having excellent sterilization power and sterilization speed according to the present invention exhibits excellent sterilization power and fast sterilization speed without using phenoxyethanol, which is a toxic substance, it is not only specialized for preventing infectious diseases, but also for surface disinfection, medical and Provided is a disinfectant composition that can be used in various fields, such as for microbial experiments, and exhibits low lung toxicity by maintaining a foam form.
이상에서 본 발명은 실시예를 중심으로 상세히 설명되었지만 본 발명의 기술사상 범위 내에서 다양한 변형 및 수정이 가능함은 당업자에게 있어서 명백한 것이며, 이러한 변형 및 수정이 첨부된 특허청구범위에 속함은 당연한 것이다.Although the present invention has been described in detail with reference to the examples above, it is obvious to those skilled in the art that various modifications and variations are possible within the scope of the technical idea of the present invention, and it is natural that such variations and modifications fall within the scope of the appended claims.
Claims (6)
A disinfectant composition with excellent sterilization power and sterilization rate, characterized in that it consists of octenidine hydrochloride, ammonium salt, surfactant and purified water.
상기 살균력과 살균속도가 우수한 소독제 조성물은 옥테니딘 염산염 0.01 내지 5 중량%, 암모늄염 0.01 내지 0.2 중량%, 계면활성제 0.1 내지 10 중량% 및 정제수 잔량으로 이루어지는 것을 특징으로 하는 살균력과 살균속도가 우수한 소독제 조성물.
The method of claim 1,
The disinfectant composition with excellent sterilization power and sterilization rate is composed of 0.01 to 5% by weight of octenidine hydrochloride, 0.01 to 0.2% by weight of ammonium salt, 0.1 to 10% by weight of surfactant, and the remaining amount of purified water Disinfectant with excellent sterilization power and sterilization rate, characterized in that composition.
상기 옥테니딘 염산염은 옥테니딘디히드로클로라이드로 이루어지는 것을 특징으로 하는 살균력과 살균속도가 우수한 소독제 조성물.
According to claim 1 or 2,
The octenidine hydrochloride is a disinfectant composition with excellent sterilization power and sterilization rate, characterized in that consisting of octenidine dihydrochloride.
상기 암모늄염은 디알킬디메틸암모늄클로라이드, 디옥틸알킬디메틸암모늄클로라이드,디데실알킬디메틸암모늄클로라이드 및 옥틸데실알킬암모늄클로라이드로 이루어진 그룹에서 선택된 하나 이상으로 이루어지는 것을 특징으로 하는 살균력과 살균속도가 우수한 소독제 조성물.
According to claim 1 or 2,
The ammonium salt is a disinfectant composition with excellent sterilization power and sterilization rate, characterized in that it consists of at least one selected from the group consisting of dialkyldimethylammonium chloride, dioctylalkyldimethylammonium chloride, didecylalkyldimethylammonium chloride and octyldecylalkylammonium chloride.
상기 계면활성제는 알킬옥사이드로 이루어지는 것을 특징으로 하는 살균력과 살균속도가 우수한 소독제 조성물.
According to claim 1 or 2,
The surfactant is a disinfectant composition with excellent sterilization power and sterilization rate, characterized in that consisting of alkyl oxide.
상기 알킬옥사이드는 데실아민옥사이드 및 라우라민옥사이드로 이루어진 그룹에서 선택된 하나 이상으로 이루어지는 것을 특징으로 하는 살균력과 살균속도가 우수한 소독제 조성물.
The method of claim 5,
The alkyl oxide is a disinfectant composition with excellent sterilization power and sterilization rate, characterized in that consisting of one or more selected from the group consisting of decylamine oxide and lauramine oxide.
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20170005407A (en) | 2014-03-28 | 2017-01-13 | 가마 헬스케어 리미티드 | A liquid antimicrobial composition |
| KR101718306B1 (en) | 2015-07-27 | 2017-03-27 | 주식회사 퍼슨 | The improved method for preparing octenidine dihydrochloride and the method for preparing a pharmaceutical composition containing the octenidine dihydrochloride |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20170005407A (en) | 2014-03-28 | 2017-01-13 | 가마 헬스케어 리미티드 | A liquid antimicrobial composition |
| KR101718306B1 (en) | 2015-07-27 | 2017-03-27 | 주식회사 퍼슨 | The improved method for preparing octenidine dihydrochloride and the method for preparing a pharmaceutical composition containing the octenidine dihydrochloride |
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