KR20230088743A - 치료제의 지속성 전달을 위한 베르시칸(vg1)의 히알루론산 결합 유도체 - Google Patents

치료제의 지속성 전달을 위한 베르시칸(vg1)의 히알루론산 결합 유도체 Download PDF

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KR20230088743A
KR20230088743A KR1020237015502A KR20237015502A KR20230088743A KR 20230088743 A KR20230088743 A KR 20230088743A KR 1020237015502 A KR1020237015502 A KR 1020237015502A KR 20237015502 A KR20237015502 A KR 20237015502A KR 20230088743 A KR20230088743 A KR 20230088743A
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South Korea
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seq
therapeutic molecule
component
hyaluronan
domain
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Korean (ko)
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로버트 프랭클린 주니어 켈리
슈레니크 체탄 메타
데빈 브렌트 테사르
라미 한노우쉬
사이먼 테오도르 한센
스티븐 덴글
휴버트 케텐베르거
페터 미카엘 휠스만
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제넨테크, 인크.
에프. 호프만-라 로슈 아게
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Publication of KR20230088743A publication Critical patent/KR20230088743A/ko
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
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    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70578—NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
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    • C07K16/22—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
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    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/44—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material not provided for elsewhere, e.g. haptens, metals, DNA, RNA, amino acids
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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  • Polysaccharides And Polysaccharide Derivatives (AREA)
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KR1020237015502A 2020-10-15 2021-10-14 치료제의 지속성 전달을 위한 베르시칸(vg1)의 히알루론산 결합 유도체 Pending KR20230088743A (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US202063092251P 2020-10-15 2020-10-15
US63/092,251 2020-10-15
US202163250782P 2021-09-30 2021-09-30
US63/250,782 2021-09-30
PCT/US2021/054965 WO2022081835A1 (en) 2020-10-15 2021-10-14 Hyaluronic acid binding derivatives of versican (vg1) for long acting delivery of therapeutics

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KR20230088743A true KR20230088743A (ko) 2023-06-20

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KR1020237015502A Pending KR20230088743A (ko) 2020-10-15 2021-10-14 치료제의 지속성 전달을 위한 베르시칸(vg1)의 히알루론산 결합 유도체
KR1020237015789A Pending KR20230088749A (ko) 2020-10-15 2021-10-14 장기 지속적 안구 전달을 위한 비공유 단백질-히알루로난 접합체

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US (2) US20230279090A1 (https=)
EP (2) EP4228706A1 (https=)
JP (2) JP2023546112A (https=)
KR (2) KR20230088743A (https=)
CN (1) CN116390767A (https=)
AU (2) AU2021360935A1 (https=)
CA (2) CA3198668A1 (https=)
IL (2) IL302087A (https=)
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USD1120314S1 (en) 2022-11-30 2026-03-24 Regeneron Pharmaceuticals, Inc. Dose delivery device
WO2025242919A1 (en) * 2024-05-24 2025-11-27 Navigo Proteins Gmbh Novel binding proteins for hyaluronic acid
WO2026022392A1 (en) * 2024-07-26 2026-01-29 Ospedale San Raffaele S.R.L. Peptide and conjugates thereof

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DE60140474D1 (de) 2000-09-08 2009-12-24 Univ Zuerich Sammlung von proteinen mit sich wiederholenden sequenzen (repeat proteins), die repetitive sequenzmodule enthalten
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EP2935589A1 (en) 2012-12-18 2015-10-28 Novartis AG Compositions and methods that utilize a peptide tag that binds to hyaluronan
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CN105008791B (zh) 2013-08-06 2017-08-29 奥林巴斯株式会社 光源光学系统、光纤光源、显微镜和汽车用前照灯
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EP4228706A1 (en) 2023-08-23
US20230279090A1 (en) 2023-09-07
JP2023546112A (ja) 2023-11-01
TW202228789A (zh) 2022-08-01
CN116390767A (zh) 2023-07-04
KR20230088749A (ko) 2023-06-20
WO2022081835A1 (en) 2022-04-21
IL302087A (en) 2023-06-01
AU2021360935A8 (en) 2023-06-29
TW202228790A (zh) 2022-08-01
AU2021360935A1 (en) 2023-05-25
EP4228702A1 (en) 2023-08-23
IL302089A (en) 2023-06-01
AU2021361108A1 (en) 2023-05-25
CA3198810A1 (en) 2022-04-21
AU2021360935A9 (en) 2024-10-03
JP2023545514A (ja) 2023-10-30
US20230256107A1 (en) 2023-08-17
WO2022079161A1 (en) 2022-04-21
CA3198668A1 (en) 2022-04-21

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