KR20230087186A - Cosmetic composition for anti-oxidation, anti-inflammation, pore tightening, or anti-wrinkle comprising extract of Aeonium sediforium as an active ingredient - Google Patents
Cosmetic composition for anti-oxidation, anti-inflammation, pore tightening, or anti-wrinkle comprising extract of Aeonium sediforium as an active ingredient Download PDFInfo
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- KR20230087186A KR20230087186A KR1020210175916A KR20210175916A KR20230087186A KR 20230087186 A KR20230087186 A KR 20230087186A KR 1020210175916 A KR1020210175916 A KR 1020210175916A KR 20210175916 A KR20210175916 A KR 20210175916A KR 20230087186 A KR20230087186 A KR 20230087186A
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- extract
- soinje
- present
- antioxidant
- aeonium
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- XOOUIPVCVHRTMJ-UHFFFAOYSA-L zinc stearate Chemical compound [Zn+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O XOOUIPVCVHRTMJ-UHFFFAOYSA-L 0.000 description 1
- CPYIZQLXMGRKSW-UHFFFAOYSA-N zinc;iron(3+);oxygen(2-) Chemical compound [O-2].[O-2].[O-2].[O-2].[Fe+3].[Fe+3].[Zn+2] CPYIZQLXMGRKSW-UHFFFAOYSA-N 0.000 description 1
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
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- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
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- A—HUMAN NECESSITIES
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Abstract
Description
소인제(Aeonium sediforium) 추출물을 유효성분으로 포함하는 항산화, 항염증, 모공축소, 또는 주름예방 및 개선용 화장료 조성물 등에 관한 것이다.It relates to a cosmetic composition for antioxidation, anti-inflammatory, pore reduction, or wrinkle prevention and improvement containing Aeonium sediforium extract as an active ingredient.
최근 경제성장에 따라 생활 수준이 향상되면서 정신적, 신체적 건강을 위한 자연주의적 열풍이 강해지고 있으며, 이로 인해 식품을 비롯하여 화장품, 제약, 의료 분야에서도 천연물에 대한 관심이 높아지고 있다. 그 중에서도 K-뷰티 시대의 도래로 인한 기능성 화장품에 대한 시장이 활성화되면서 화학적인 성분에서 유래되는 피부에 대한 부작용을 최소화할 수 있는 새로운 천연물 유래의 기능성 물질을 찾으려는 관심이 증대되고, 천연물 추출물에 대한 효능과 안정성에 대한 연구와 노력이 활발하게 진행되고 있다. Recently, as the standard of living has improved along with economic growth, the craze for naturalism for mental and physical health is getting stronger, and as a result, interest in natural products is increasing in the fields of cosmetics, pharmaceuticals, and medicine as well as food. Among them, as the market for functional cosmetics has been activated due to the arrival of the K-beauty era, interest in finding new functional substances derived from natural substances that can minimize side effects on the skin derived from chemical components has increased, and Research and efforts are being actively conducted on the efficacy and safety of
생활 환경은 좋아지고 있지만 환경 오염을 비롯하여 현대인들의 극심한 스트레스, 무분별한 기능성 화장품의 남용과 오용은 피부의 노화뿐만 아니라 피부 질환 일으키는 주원인이 되고 있다. 피부 질환 개선을 위한 천연 식물체에 주로 존재하는 항산화 물질인 폴리페놀 물질은 생체내의 활성산소의 반응성을 감소시켜 피부질환을 예방하고, 지연시키는 효과가 있다고 알려져 있어, 화장품 분야에서는 천연 항산화 물질에 대한 많은 연구가 진행되고 있다. 뿐만 아니라, 건강에 대한 관심이 높아지면서 미용을 목적으로 천연 식물체에서 유래된 기능성 소재에 대한 연구도 활발하게 이루어지고 있으며, 다양한 천연물질을 이용한 항산화, 주름개선, 미백, 보습, 피부노화 억제 효과 등이 과학적으로 입증되고 있다. 이러한 천연물 소재는 화학 성분이 갖는 문제점이나 부작용을 보완할 수 있기 때문에 기능성 화장품 연구에서 주목을 받고 있다. Although the living environment is improving, environmental pollution, extreme stress of modern people, and indiscriminate abuse and misuse of functional cosmetics are the main causes of skin aging as well as skin diseases. Polyphenol substances, which are antioxidants mainly present in natural plants for improving skin diseases, are known to have an effect of preventing and delaying skin diseases by reducing the reactivity of active oxygen in the body. Research is ongoing. In addition, as interest in health increases, research on functional materials derived from natural plants for beauty purposes is actively conducted, and antioxidant, wrinkle improvement, whitening, moisturizing, and skin aging inhibition effects using various natural substances This is scientifically proven. Since these natural materials can supplement the problems or side effects of chemical ingredients, they are attracting attention in functional cosmetics research.
항산화 활성이란 생체 내에 활성산소가 생성되는 것을 방지하고, 회복이 불가능한 세포의 손상을 야기시키는 산화 현상을 방지하는 것을 의미한다. 안정한 상태의 산소(triplet-2-oxygen)는 환원 대사, 효소계, 공해물질, 광화학 반응과 같은 생화학적 및 환경적 요인 등에 의해 수퍼옥사이드 라디칼, 과산화수소, 하이드록시 라디칼과 같은 반응성이 큰 활성산소(ROS; reactive oxygen species)로 전환되어 세포 구성성분을 비가역적으로 파괴한다. 이러한 활성산소의 작용은 체내 방어 기구인 수퍼옥사이드디스뮤타제(Superoxide dismutase), 퍼옥시다아제(peroxidase), 카탈라아제(catalase) 등의 항산화 효소와 비타민E, 비타민 C, 글루타티온(glutathione) 등의 항산화 물질들의 작용에 의해 최소화 될 수 있다. 하지만, 이러한 생체 방어력에 이상이 생기거나 과도한 활성 산소에 노출될 경우, 이 균형이 무너지게 되면서 활성산소는 지질, DNA, 단백질 등을 비가역적으로 파괴하여 손상시킨다. 그 결과로 노화, 암, 복합성 동맥경화, 관절염 및 파킨슨병 등과 같은 각종 질병이 발생할 수 있다. 합성 항산화제는 생체 내에서 독성을 나타내어 종양과 알레르기를 발생시킬 수 있는 문제점이 있으며 온도에 약해 한번 열을 가하면 쉽게 파괴되는 문제점도 있다. 반면에, 천연 항산화제는 합성 항산화제와 비교했을 때 생체에 안전하다는 장점이 있으나, 그 효과가 약하다는 문제점이 있다. 따라서, 항산화 활성이 우수하고 보다 인체에 안전한 새로운 천연 항산화제의 개발과 연구가 절실히 필요한 상황이다.Antioxidant activity means that active oxygen is prevented from being generated in a living body and an oxidation phenomenon that causes irreversible cell damage is prevented. Oxygen in a stable state (triplet-2-oxygen) can be converted into reactive oxygen species (ROS) such as superoxide radicals, hydrogen peroxide, and hydroxyl radicals by biochemical and environmental factors such as reduction metabolism, enzyme systems, pollutants, and photochemical reactions. reactive oxygen species) and irreversibly destroy cellular components. The action of these reactive oxygen species is the defense mechanism of the body, such as superoxide dismutase, peroxidase, and catalase, and antioxidant enzymes, such as vitamin E, vitamin C, and glutathione. action can be minimized. However, when there is an abnormality in these biological defenses or when exposed to excessive active oxygen, this balance is broken, and active oxygen irreversibly destroys and damages lipids, DNA, proteins, and the like. As a result, various diseases such as aging, cancer, complex arteriosclerosis, arthritis and Parkinson's disease can occur. Synthetic antioxidants have a problem of being toxic in vivo and causing tumors and allergies, and are also vulnerable to temperature and are easily destroyed once heat is applied. On the other hand, natural antioxidants have the advantage of being safe to the body compared to synthetic antioxidants, but have a weak effect. Therefore, there is an urgent need to develop and research new natural antioxidants that have excellent antioxidant activity and are safer for the human body.
소인제(Aeonium sedifolium)는 다육 식물에 속하고 가을에서 봄에 성장하며 잎 길이는 2 cm 정도이며, 끈적거리는 특성이 있다. 또한, 줄기는 얇고 진한 갈색을 띠며 잘 부러지며, 잎은 원통형이며 생육온도는 3 내지 35℃로 충분히 광을 받아야 웃자람이 없고 잎의 무늬가 선명해진다. 원산지는 카나리제도로 에오니움(Aeonium)속으로 돌나무과다. 아프리카 북부와 인근 섬에 자생하고 있는 에오니움속 다육식물은 노출된 줄기 끝에 로제트형상인 납빛의 잎이 있는데, 이 잎들은 꽃이 진 후 낙엽이 되어 떨어지는 습성을 가지고 있다. 몇몇 종은 매혹적인 색채를 가진다. 에오니움속 대부분은 중앙에 줄기가 있고 줄기 끝에 잎들이 달린 모양이다. 줄기는 목질화되어 있고 통상 기근(氣根)을 낸다.Aeonium sedifolium belongs to succulents, grows from autumn to spring, has leaves about 2 cm long, and has sticky properties. In addition, the stem is thin and dark brown, and the leaves are cylindrical, and the growth temperature is 3 to 35 ℃, so there is no overgrowth and the leaf pattern becomes clear. It is native to the Canary Islands and belongs to the genus Aeonium. The succulents of the genus Aeonium, which are native to northern Africa and nearby islands, have rosette-shaped, lead-colored leaves at the end of exposed stems, and these leaves have a habit of falling as leaves after flowers wither. Some species have attractive colors. Most of the genus Aeonium have a stem in the center and leaves at the end of the stem. Stems are lignified and usually produce aerial roots.
현재까지 소인제에 대한 연구는 다육 식물로서의 식물학적 특성에 대한 연구 외에, 소인제 잎 추출물을 이용한 생리활성 및 기능성 검증에 관한 연구는 아직 전무한 실정이다. 따라서 본 발명자들은 소인제 잎 추출물의 항염증, 항산화, 모공축소, 주름예방 및 개선 효과를 검증하여 피부 미용 기능성 소재로 적용 가능성을 확인하고자 한다.So far, studies on soinje have not yet been studied on physiological activity and functional verification using soinje leaf extract, in addition to studies on the botanical characteristics as a succulent plant. Therefore, the inventors of the present invention tried to confirm the applicability as a skin care functional material by verifying the anti-inflammatory, antioxidant, pore reduction, wrinkle prevention and improvement effects of Soinje leaf extract.
본 발명자들은 소인제 추출물이 항산화, 항염증, 모공축소, 주름예방 및 개선 효과를 확인 하였는바, 이에 기초하여 본 발명을 완성하였다.The present inventors confirmed the antioxidant, anti-inflammatory, pore reduction, wrinkle prevention and improvement effects of Soinje extract, and based on this, the present invention was completed.
이에 본 발명의 목적은 소인제(Aeonium sediforium) 추출물을 유효성분으로 포함하는, 항산화용; 항염증용; 모공축소용; 또는 주름예방 및 개선용 화장료 조성물을 제공하는 것이다.Accordingly, an object of the present invention is soinje ( Aeonium sediforium ) For antioxidant, including an extract as an active ingredient; for anti-inflammatory use; for pore reduction; Or to provide a cosmetic composition for preventing and improving wrinkles.
본 발명의 다른 목적은 소인제(Aeonium sediforium) 추출물을 유효성분으로 포함하는, 항산화용; 항염증용; 모공축소용; 또는 주름예방 및 개선용 식품 조성물을 제공하는 것이다.Another object of the present invention is soinje ( Aeonium sediforium ) For antioxidant, including an extract as an active ingredient; for anti-inflammatory use; for pore reduction; Or to provide a food composition for preventing and improving wrinkles.
본 발명의 또 다른 목적은 소인제(Aeonium sediforium) 추출물을 유효성분으로 포함하는, 항산화용; 또는 항염증용 약학적 조성물을 제공하는 것이다.Another object of the present invention is soinje ( Aeonium sediforium ) For antioxidant, including an extract as an active ingredient; Or to provide a pharmaceutical composition for anti-inflammatory.
그러나, 본 발명이 이루고자 하는 기술적 과제는 이상에서 언급한 과제에 제한되지 않으며, 언급되지 않은 또 다른 과제들은 아래의 기재로부터 본 발명이 속하는 기술 분야의 통상의 지식을 가진 자에게 명확하게 이해될 수 있을 것이다.However, the technical problem to be achieved by the present invention is not limited to the above-mentioned problems, and other problems not mentioned can be clearly understood by those skilled in the art from the description below. There will be.
상기 본 발명의 목적을 달성하기 위하여, 본 발명은 소인제(Aeonium sediforium) 추출물을 유효성분으로 포함하는, 항산화용; 항염증용; 모공축소용; 또는 주름예방 및 개선용 화장료 조성물을 제공한다.In order to achieve the object of the present invention, the present invention soinje ( Aeonium sediforium ) For antioxidant comprising an extract as an active ingredient; for anti-inflammatory use; for pore reduction; Or it provides a cosmetic composition for preventing and improving wrinkles.
또한, 본 발명은 소인제(Aeonium sediforium) 추출물을 유효성분으로 포함하는, 항산화용; 항염증용; 모공축소용; 또는 주름예방 및 개선용 식품 조성물을 제공한다.In addition, the present invention soinje ( Aeonium sediforium ) For antioxidant, including an extract as an active ingredient; for anti-inflammatory use; for pore reduction; Or it provides a food composition for preventing and improving wrinkles.
또한, 본 발명은 소인제(Aeonium sediforium) 추출물을 유효성분으로 포함하는, 항산화용; 또는 항염증용 약학적 조성물을 제공한다.In addition, the present invention soinje ( Aeonium sediforium ) For antioxidant, including an extract as an active ingredient; Or it provides a pharmaceutical composition for anti-inflammatory.
본 발명의 일 구현예에서 상기 소인제 추출물은 소인제 잎 추출물인 것을 특징으로 할 수 있으나, 이에 제한되지 않는다.In one embodiment of the present invention, the soinje extract may be characterized in that the soinje leaf extract, but is not limited thereto.
본 발명의 다른 구현예에서 상기 소인제 추출물은 DPPH(1,1-diphenyl-2-picrylhydrazyl) 라디칼 저해, ABTS(2,2’-Azinobis-(3-ethylbenzothiazoline-6-sulfonic acid) 라디칼 저해, TBARs(Thiobarbituric acid reactive substances) 저해, 또는 PF(Antioxidant protection factor) 증가 활성을 가지는 것을 특징으로 할 수 있으나, 이에 제한되지 않는다.In another embodiment of the present invention, the soinje extract is DPPH (1,1-diphenyl-2-picrylhydrazyl) radical inhibition, ABTS (2,2'-Azinobis- (3-ethylbenzothiazoline-6-sulfonic acid) radical inhibition, TBARs (Thiobarbituric acid reactive substances) inhibition or PF (Antioxidant protection factor) may be characterized by having an increasing activity, but is not limited thereto.
본 발명의 또 다른 구현예에서 상기 소인제 추출물은 하기 특징 중 하나 이상을 만족하는 것을 특징으로 할 수 있으나, 이에 제한되지 않는다:In another embodiment of the present invention, the soinje extract may be characterized in that it satisfies one or more of the following characteristics, but is not limited thereto:
(a) 히알루로니다제(hyaluronidase)를 저해;(a) inhibit hyaluronidase;
(b) 수렴작용(astringent)을 나타냄; 및(b) exhibits astringent action; and
(c) 엘라스타제(elastase) 또는 콜라게나제(collagenase)를 저해.(c) inhibition of elastase or collagenase.
본 발명의 또 다른 구현예에서 상기 소인제 추출물은 물, C1 내지 C4의 저급알코올, n-헥산, 에틸아세테이트, 아세톤, 아세토니트릴, 부틸아세테이트, 1,3-부틸렌 글리콜, 메틸렌클로라이드, 및 이들의 혼합용매로 구성된 군으로부터 선택된 용매로 추출된 것을 특징으로 할 수 있으나, 이에 제한되지 않는다.In another embodiment of the present invention, the disinfectant extract is water, C 1 to C 4 lower alcohol, n-hexane, ethyl acetate, acetone, acetonitrile, butyl acetate, 1,3-butylene glycol, methylene chloride, And it may be characterized in that extracted with a solvent selected from the group consisting of a mixed solvent thereof, but is not limited thereto.
본 발명의 또 다른 양태로서, 본 발명은 소인제 추출물을 유효성분으로 포함하는 조성물을 개체에 투여하는 단계를 포함하는, 항산화, 항염증, 모공축소, 주름예방 또는 개선 방법을 제공한다.As another aspect of the present invention, the present invention provides a method for antioxidation, anti-inflammatory, pore reduction, wrinkle prevention or improvement comprising the step of administering to a subject a composition containing a soinje extract as an active ingredient.
본 발명의 또 다른 양태로서, 본 발명은 소인제 추출물을 유효성분으로 포함하는 조성물을 개체에 투여하는 단계를 포함하는 항산화, 항염증, 모공축소, 주름예방 또는 개선을 위한 미용 방법을 제공한다.As another aspect of the present invention, the present invention provides a cosmetic method for antioxidation, anti-inflammatory, pore reduction, wrinkle prevention or improvement comprising the step of administering to a subject a composition containing a soinje extract as an active ingredient.
본 발명의 또 다른 양태로서, 본 발명은 소인제 추출물을 유효성분으로 포함하는 조성물의 항산화, 항염증, 모공축소, 주름예방 또는 개선 용도를 제공한다.As another aspect of the present invention, the present invention provides antioxidant, anti-inflammatory, pore reduction, anti-wrinkle or improvement uses of a composition containing a soinje extract as an active ingredient.
본 발명의 또 다른 양태로서, 본 발명은 소인제 추출물을 유효성분으로 포함하는 조성물의 항산화, 항염증, 모공축소, 주름예방 또는 개선에 이용되는 화장품을 생산하기 위한 용도를 제공한다.As another aspect of the present invention, the present invention provides the use of a composition containing a soinje extract as an active ingredient for producing cosmetics used for antioxidation, anti-inflammatory, pore reduction, wrinkle prevention or improvement.
본 발명의 또 다른 양태로서, 본 발명은 항산화, 또는 항염증에 이용되는 약제를 생산하기 위한 소인제 추출물의 용도를 제공한다.As another aspect of the present invention, the present invention provides the use of a soinje extract for producing a drug used for antioxidant or anti-inflammatory.
본 발명에 따른 소인제 추출물은 DPPH 라디칼, ABTS 라디칼, 및 TBARs를 저해하고 PF를 증가시킴으로써 항산화 효과를 가지며, 히알루로니다제를 저해함으로써 항염증 효과를 나타낸다. 또한, 소인제 추출물은 엘라스타제 또는 콜라게나제를 저해함으로써 주름개선 효과를 가지고, 수렴효과를 나타내어 모공축소 효과를 나타내는 바, 상기와 같은 생리활성을 가지는 약학적 조성물, 식품 조성물, 또는 화장료 조성물 등으로 유용하게 이용될 수 있을 것으로 기대된다. Soinje extract according to the present invention has an antioxidant effect by inhibiting DPPH radical, ABTS radical, and TBARs and increasing PF, and exhibits anti-inflammatory effect by inhibiting hyaluronidase. In addition, the soinje extract has an anti-wrinkle effect by inhibiting elastase or collagenase, and a pore-reducing effect by exhibiting an astringent effect. A pharmaceutical composition, food composition, or cosmetic composition having the above physiological activity It is hoped that it can be usefully used.
도 1은 본 발명의 일 구현예에 따른 소인제 추출물에서 에탄올 용매 농도별 페놀 함량을 나타낸 것이다.
도 2a는 본 발명의 일 구현예에 따른 소인제의 열수, 및 50% 에탄올 추출물의 DPPH 라디칼 소거 활성을 확인한 결과를 나타낸 것이다.
도 2b는 본 발명의 일 구현예에 따른 소인제의 열수, 및 50% 에탄올 추출물의 ABTS 라디칼 억제 활성을 확인한 결과를 나타낸 것이다.
도 2c는 본 발명의 일 구현예에 따른 소인제의 열수, 및 50% 에탄올 추출물의 PF를 측정한 결과를 나타낸 것이다.
도 2d는 본 발명의 일 구현예에 따른 소인제의 열수, 및 50% 에탄올 추출물의 TBARs 저해 활성을 확인한 결과를 나타낸 것이다.
도 3은 본 발명의 일 구현예에 따른 소인제의 열수, 및 50% 에탄올 추출물의 엘라스타제 저해 활성을 확인한 결과를 나타낸 것이다.
도 4는 본 발명의 일 구현예에 따른 소인제의 열수, 및 50% 에탄올 추출물의 콜라게나제 저해 활성을 확인한 결과를 나타낸 것이다.
도 5는 본 발명의 일 구현예에 따른 소인제의 열수, 및 50% 에탄올 추출물의 수렴 효과를 확인한 결과를 나타낸 것이다.
도 6은 본 발명의 일 구현예에 따른 소인제의 열수, 및 50% 에탄올 추출물의 히알루로니다제 저해 활성을 확인한 결과를 나타낸 것이다.Figure 1 shows the phenol content by ethanol solvent concentration in the soinje extract according to an embodiment of the present invention.
Figure 2a shows the results of confirming the DPPH radical scavenging activity of hot water and 50% ethanol extract of the cleaning agent according to an embodiment of the present invention.
Figure 2b shows the results of confirming the ABTS radical inhibitory activity of hot water and 50% ethanol extract of the cleaning agent according to one embodiment of the present invention.
Figure 2c shows the results of measuring the PF of hot water and 50% ethanol extract of the cleaning agent according to an embodiment of the present invention.
Figure 2d shows the results of confirming the TBARs inhibitory activity of hot water and 50% ethanol extract of the cleaning agent according to one embodiment of the present invention.
Figure 3 shows the results of confirming the elastase inhibitory activity of hot water and 50% ethanol extract of the cleaning agent according to one embodiment of the present invention.
Figure 4 shows the results of confirming the collagenase inhibitory activity of hot water and 50% ethanol extract of the cleaning agent according to one embodiment of the present invention.
Figure 5 shows the results of confirming the astringent effect of the hot water cleaning agent and 50% ethanol extract according to one embodiment of the present invention.
Figure 6 shows the results of confirming the hyaluronidase inhibitory activity of hot water and 50% ethanol extract of the cleaning agent according to one embodiment of the present invention.
본 발명의 일 실험예에서는 소인제 추출물에서 열수, 및 에탄올 용매 농도별 페놀 함량을 확인한 결과, 50 % 에탄올로 추출한 추출물에서 가장 페놀 함량이 높은 것을 확인하였다(실험예 1 참조).In one experimental example of the present invention, as a result of confirming the phenol content by hot water and ethanol solvent concentration in the Soinje extract, it was confirmed that the highest phenol content was obtained in the extract extracted with 50% ethanol (see Experimental Example 1).
본 발명의 또 다른 실험예에서는 소인제 추출물이 DPPH 라디칼 소거 활성, ABTS 라디칼 억제 활성, PF 항산화 활성, 및 TBARs 저해 활성을 나타내어 항산화 효과를 가지는 것을 확인하였다(실험예 2 참조).In another experimental example of the present invention, it was confirmed that the Soinje extract had an antioxidant effect by exhibiting DPPH radical scavenging activity, ABTS radical inhibitory activity, PF antioxidant activity, and TBARs inhibitory activity (see Experimental Example 2).
본 발명의 또 다른 실험예에서는 소인제 추출물이 엘라스타제 저해 활성, 및 콜라게나제 저해 활성을 나타내어 주름개선 효과를 가지는 것을 확인하였다(실험예 3 및 4 참조).In another experimental example of the present invention, it was confirmed that the soinje extract exhibited elastase inhibitory activity and collagenase inhibitory activity to have an anti-wrinkle effect (see Experimental Examples 3 and 4).
본 발명의 또 다른 실험예에서는 소인제 추출물이 수렴 효과를 나타내는바, 모공축소 효과를 가지는 것을 확인하였다(실험예 5 참조).In another experimental example of the present invention, it was confirmed that the soinje extract exhibited an astringent effect and had a pore-reducing effect (see Experimental Example 5).
본 발명의 또 다른 실험예에서는 소인제 추출물이 히알루로니다제 저해 활성을 나타내어 항염증 효과를 가지는 것을 확인하였다(실험예 6 참조).In another experimental example of the present invention, it was confirmed that the soinje extract exhibited hyaluronidase inhibitory activity and thus had an anti-inflammatory effect (see Experimental Example 6).
따라서, 본 발명의 소인제 추출물이 DPPH 라디칼 소거 활성, ABTS 라디칼 억제 활성, PF 항산화 활성, 및 TBARs 저해 활성, 엘라스타제 저해 활성, 및 콜라게나제 저해 활성을 나타내고, 수렴 효과, 및 히알루로니다제 저해 활성을 나타내는 바, 항산화, 항염증, 주름개선, 및 모공축소 용도로 사용 가능할 것으로 기대된다.Therefore, the Soinje extract of the present invention exhibits DPPH radical scavenging activity, ABTS radical inhibitory activity, PF antioxidant activity, and TBARs inhibitory activity, elastase inhibitory activity, and collagenase inhibitory activity, astringent effect, and hyaluronida Since it exhibits inhibitory activity, it is expected that it can be used for antioxidant, anti-inflammatory, wrinkle improvement, and pore reduction purposes.
이하, 본 발명에 대해 상세히 설명한다.Hereinafter, the present invention will be described in detail.
본 발명은 소인제(Aeonium sediforium) 추출물을 유효성분으로 포함하는, 항산화용; 항염증용; 모공축소용; 또는 주름예방 및 개선용 화장료 조성물을 제공한다. The present invention soinje ( Aeonium sediforium ) For antioxidant, including an extract as an active ingredient; for anti-inflammatory use; for pore reduction; Or it provides a cosmetic composition for preventing and improving wrinkles.
본 발명에 있어서, “소인제(Aeonium sedifolium)”는 다육 식물에 속하고 가을에서 봄에 성장하며 잎 길이는 2 cm 정도이며, 끈적거리는 특성이 있다. 또한, 줄기는 얇고 진한 갈색을 띠며 잘 부러지며, 잎은 원통형이며 생육온도는 3 내지 35℃로 충분히 광을 받아야 웃자람이 없고 잎의 무늬가 선명해지는 특성이 있다. 상기 소인제 추출물은 소인제의 잎, 줄기, 근경(뿌리줄기), 뿌리, 또는 이를 모두 포함한 식물 전체 추출물일 수 있으며, 본 발명의 일 실시예에 따르면 소인제 잎 추출물일 수 있으나, 이에 제한되지 않는다. 상기 소인제는 직접 재배한 것 또는 시판되는 것 등을 제한 없이 사용할 수 있다.In the present invention, "Aeonium sedifolium" belongs to succulents, grows from autumn to spring, has a leaf length of about 2 cm, and has a sticky property. In addition, the stem is thin and dark brown, and the leaves are cylindrical, and the growth temperature is 3 to 35 ℃, so there is no overgrowth and the leaf pattern is clear. The soinje extract may be a whole plant extract including leaves, stems, rhizomes (rhizomes), roots, or all of them, and according to one embodiment of the present invention, it may be a soinje leaf extract, but is not limited thereto. don't The disinfectant may be directly grown or commercially available without limitation.
본 발명에 있어서, “추출물”은 상기 소인제의 추출처리에 의하여 얻어지는 추출액, 상기 추출액의 희석액이나 농축액, 상기 추출액을 건조하여 얻어지는 건조물, 상기 추출액의 조정제물이나 정제물, 또는 이들의 혼합물 등, 추출액 자체 및 추출액을 이용하여 형성 가능한 모든 제형의 추출물을 포함한다. 본 발명의 일 실시예에 따르면, 상기 소인제 추출물은 건조물 형태일 수 있으나, 이에 제한되지 않는다.In the present invention, “extract” refers to an extract obtained by the extraction treatment of the cleaning agent, a diluted or concentrated liquid of the extract, a dried product obtained by drying the extract, a crude product or a purified product of the extract, or a mixture thereof, It includes the extract itself and extracts of all formulations that can be formed using the extract. According to one embodiment of the present invention, the soinje extract may be in the form of dry matter, but is not limited thereto.
본 발명에 있어서, 상기 소인제 추출물의 추출 방법은 특별히 제한되지 아니하며, 당해 기술분야에서 통상적으로 사용하는 방법에 따라 추출할 수 있다. 상기 추출 방법의 비제한적인 예로는, 열수 추출법, 초음파 추출법, 여과법, 환류 추출법, 초임계 추출법, 아임계 추출법, 고온 추출, 고압 추출, 용매 추출법 등을 들 수 있으며, 이들은 단독으로 수행되거나 2 종 이상의 방법을 병용하여 수행될 수 있다.In the present invention, the extraction method of the soinje extract is not particularly limited, and may be extracted according to a method commonly used in the art. Non-limiting examples of the extraction method include hot water extraction, ultrasonic extraction, filtration, reflux extraction, supercritical extraction, subcritical extraction, high temperature extraction, high pressure extraction, solvent extraction, and the like, which are performed alone or in combination with two types. The above methods may be used in combination.
본 발명에 있어서, 상기 소인제 추출물을 추출하는 데에 사용되는 추출 용매의 종류는 특별히 제한되지 아니하며, 천연물로부터 추출물을 추출하는 당업계에 공지된 통상적인 방법에 따라, 즉, 통상적인 온도, 압력의 조건 하에서 통상적인 용매를 사용하여 추출할 수 있다. 예를 들어, 상기 소인제 추출물은 물, C1 내지 C4의 저급알코올, n-헥산, 에틸아세테이트, 아세톤, 아세토니트릴, 부틸아세테이트, 1,3-부틸렌 글리콜, 메틸렌클로라이드, 및 이들의 혼합용매로 구성된 군으로부터 선택된 하나의 용매로 추출될 수 있으며, 본 발명의 일 실시예에 따르면 물 또는 에탄올을 용매로 사용하여 추출할 수 있으나, 이에 제한되지 않는다.In the present invention, the type of extraction solvent used to extract the soinje extract is not particularly limited, and according to a conventional method known in the art for extracting extracts from natural products, that is, conventional temperature and pressure It can be extracted using conventional solvents under the conditions of For example, the soinje extract is water, C 1 to C 4 lower alcohol, n -hexane, ethyl acetate, acetone, acetonitrile, butyl acetate, 1,3-butylene glycol, methylene chloride, and mixtures thereof It may be extracted with one solvent selected from the group consisting of solvents, and according to an embodiment of the present invention, extraction may be performed using water or ethanol as a solvent, but is not limited thereto.
본 발명에 있어서, 상기 에탄올을 용매로 사용하여 소인제를 추출할 경우, 에탄올의 농도는 10 % 내지 100 %, 10 % 내지 90 %, 10% 내지 80%, 10 % 내지 70 %, 10 내지 60%, 20 % 내지 100 %, 20 % 내지 90 %, 20% 내지 80%, 20 % 내지 70 %, 20 내지 60%, 30 % 내지 100 %, 30 % 내지 90 %, 30% 내지 80%, 30 % 내지 70 %, 30 내지 60%, 40 % 내지 100 %, 40 % 내지 90 %, 40% 내지 80%, 40 % 내지 70 %, 40 내지 60%, 또는 50%일 수 있으나, 이에 제한되지 않는다.In the present invention, when the ethanol is used as a solvent to extract the cleaning agent, the concentration of ethanol is 10% to 100%, 10% to 90%, 10% to 80%, 10% to 70%, 10 to 60% %, 20% to 100%, 20% to 90%, 20% to 80%, 20% to 70%, 20% to 60%, 30% to 100%, 30% to 90%, 30% to 80%, 30 % to 70%, 30 to 60%, 40% to 100%, 40% to 90%, 40% to 80%, 40% to 70%, 40 to 60%, or 50%, but is not limited thereto. .
본 발명에 있어서, 상기 제조된 추출물은 이후 여과하거나 농축 또는 건조과정을 수행하여 용매를 제거할 수 있으며, 여과, 농축 및 건조를 모두 수행할 수 있다. 예컨대, 여과는 여과지를 이용하거나 감압여과기를 이용할 수 있으며, 농축은 진공 감압 농축기 또는 진공회전증발기를 이용할 수 있고, 건조는 감압건조, 진공건조, 비등건조, 분무건조, 동결건조법 등을 수행할 수 있으나, 이에 제한되는 것은 아니다.In the present invention, the prepared extract may then be filtered or concentrated or dried to remove the solvent, and both filtration, concentration and drying may be performed. For example, filtration may use filter paper or a vacuum filter, concentration may use a vacuum vacuum concentrator or vacuum rotary evaporator, and drying may be performed by vacuum drying, vacuum drying, boiling drying, spray drying, freeze drying, and the like. However, it is not limited thereto.
본 발명에서 있어서, 추출 횟수는 1회 이상 실시할 수 있으나, 추출이 계속될수록 활성 성분은 수득량이 현저히 감소되므로 5회 이상 반복 실시하는 것은 경제적이지 않을 수 있다. 이에, 추출 횟수는 1 내지 5회인 것이 바람직하며, 2 내지 5회 반복 추출하는 것이 더욱 바람직하나, 이에 제한되는 것은 아니다. In the present invention, the number of extractions may be carried out one or more times, but as the extraction continues, the yield of the active ingredient significantly decreases, so it may not be economical to repeat the extraction five times or more. Accordingly, the number of extractions is preferably 1 to 5 times, and more preferably 2 to 5 repeated extractions, but is not limited thereto.
본 발명에 있어서, 상기 소인제 추출물은 하기 특징 중 하나 이상을 만족할 수 있으나, 이에 제한되지 않는다:In the present invention, the soinje extract may satisfy one or more of the following characteristics, but is not limited thereto:
(a) 히알루로니다제(hyaluronidase)를 저해;(a) inhibit hyaluronidase;
(b) 수렴작용(astringent)을 나타냄; 및(b) exhibits astringent action; and
(c) 엘라스타제(elastase) 또는 콜라게나제(collagenase)를 저해.(c) inhibition of elastase or collagenase.
본 발명에 있어서, "항산화"는 생체분자에 산화 손상을 일으키며, 단백질을 가교시키고, DNA를 변이시키며, 지질을 과산화시킬 수 있는 자유 라디칼 및 활성 산소를 억제하는 것을 의미한다.In the present invention, "antioxidation" means inhibiting free radicals and reactive oxygen species that can cause oxidative damage to biomolecules, cross-link proteins, mutate DNA, and peroxidize lipids.
본 발명에 있어서, “주름예방 및 개선”은 피부에 주름이 생성되는 것을 억제 또는 저해하거나, 이미 생성된 주름을 완화시키는 것을 의미한다. In the present invention, "preventing and improving wrinkles" means suppressing or inhibiting the formation of wrinkles on the skin, or alleviating wrinkles already created.
본 발명에 따른 화장료 조성물의 제형은 스킨로션, 스킨소프너, 스킨토너, 아스트린젠트, 로션, 밀크로션, 모이스쳐 로션, 영양로션, 맛사지크림, 영양크림, 미스트, 모이스쳐 크림, 핸드크림, 핸드로션, 파운데이션, 에센스, 영양에센스, 팩, 비누, 클렌징폼, 클렌징로션, 클렌징크림, 클렌징오일, 클렌징밤, 바디로션 또는 바디클렌저의 형태일 수 있다.The formulation of the cosmetic composition according to the present invention is skin lotion, skin softener, skin toner, astringent, lotion, milk lotion, moisture lotion, nutrient lotion, massage cream, nutrient cream, mist, moisture cream, hand cream, hand lotion, foundation, It may be in the form of essence, nutritional essence, pack, soap, cleansing foam, cleansing lotion, cleansing cream, cleansing oil, cleansing balm, body lotion, or body cleanser.
본 발명의 화장료 조성물은 수용성 비타민, 유용성 비타민, 고분자 펩티드, 고분자 다당, 및 스핑고 지질로 이루어진 군에서 선택된 조성물을 더 포함할 수 있다.The cosmetic composition of the present invention may further include a composition selected from the group consisting of water-soluble vitamins, oil-soluble vitamins, high-molecular peptides, high-molecular polysaccharides, and sphingolipids.
수용성 비타민으로서는 화장품에 배합 가능한 것이라면 어떠한 것이라도 되지만, 예를 들어 비타민 B1, 비타민 B2, 비타민 B6, 피리독신, 염산피리독신, 비타민 B12, 판토텐산, 니코틴산, 니코틴산아미드, 엽산, 비타민 C, 비타민 H 등을 들 수 있으며, 그들의 염(티아민염산염, 아스코르빈산나트륨염 등)이나 유도체(아스코르빈산-2-인산나트륨염, 아스코르빈산-2-인산마그네슘염 등)도 본 발명에서 사용할 수 있는 수용성 비타민에 포함된다. 수용성 비타민은 미생물 변환법, 미생물의 배양물로부터의 정제법, 효소법 또는 화학 합성법 등의 통상의 방법에 의해 수득할 수 있다.Any water-soluble vitamin can be used as long as it can be incorporated into cosmetics, but examples include vitamin B1, vitamin B2, vitamin B6, pyridoxine, pyridoxine hydrochloride, vitamin B12, pantothenic acid, nicotinic acid, nicotinic acid amide, folic acid, vitamin C, and vitamin H. salts (thiamine hydrochloride, sodium ascorbate, etc.) or derivatives (sodium ascorbic acid-2-phosphate, magnesium salt of ascorbic acid-2-phosphate, etc.) included Water-soluble vitamins can be obtained by conventional methods such as a microbial transformation method, a purification method from a microbial culture, an enzymatic method, or a chemical synthesis method.
유용성 비타민으로서는 화장품에 배합 가능한 것이라면 어떠한 것이라도 되지만, 예를 들어 비타민 A, 카로틴, 비타민 D2, 비타민 D3, 비타민 E(d1-알파 토코페롤, d-알파 토코페롤) 등을 들 수 있으며, 그들의 유도체(팔미틴산아스코르빈, 스테아르산아스코르빈, 디팔미틴산아스코르빈, 아세트산 dl-알파 토코페롤, 니코틴산 dl-알파 토코페롤 비타민 E, DL-판토테닐알코올, D-판토테닐알코올, 판토테닐에틸에테르 등) 등도 본 발명에서 사용되는 유용성 비타민에 포함된다. 유용성 비타민은 미생물 변환법, 미생물의 배양물로부터의 정제법, 효소 또는 화학 합성법 등의 통상의 방법에 의해 취득할 수 있다.Any useful vitamin can be used as long as it can be formulated into cosmetics, but examples thereof include vitamin A, carotene, vitamin D2, vitamin D3, vitamin E (d1-alpha tocopherol, d-alpha tocopherol), and their derivatives (palmitic acid). Ascorbine, ascorbine stearate, ascorbine dipalmitate, dl-alpha tocopherol acetate, dl-alpha tocopherol nicotinate, vitamin E, DL-pantothenyl alcohol, D-pantothenyl alcohol, pantothenyl ethyl ether, etc.) Included in the useful vitamins used in the invention. The useful vitamins can be obtained by conventional methods such as microbial transformation, purification from microbial culture, enzymatic or chemical synthesis.
고분자 펩티드로서는 화장품에 배합 가능한 것이라면 어떠한 것이라도 되지만, 예를 들어 콜라겐, 가수 분해 콜라겐, 젤라틴, 엘라스틴, 가수 분해 엘라스틴, 케라틴 등을 들 수 있다. 고분자 펩티드는 미생물의 배양액으로부터의 정제법, 효소법 또는 화학 합성법 등의 통상의 방법에 의해 정제 취득할 수 있으며, 또는 통상 돼지나 소 등의 진피, 누에의 견섬유 등의 천연물로부터 정제하여 사용할 수 있다.Any polymer peptide may be used as long as it can be incorporated into cosmetics, and examples thereof include collagen, hydrolyzed collagen, gelatin, elastin, hydrolyzed elastin, and keratin. Polymer peptides can be purified and obtained by conventional methods such as a purification method from a culture medium of microorganisms, an enzyme method, or a chemical synthesis method, or can be used after being purified from natural products such as pig or cow dermis or silkworm silk fibers.
고분자 다당으로서는 화장품에 배합 가능한 것이라면 어떠한 것이라도 되지만, 예를 들어 히드록시에틸셀룰로오스, 크산탄검, 히알루론산나트륨, 콘드로이틴 황산 또는 그 염(나트륨염 등) 등을 들 수 있다. 예를 들어, 콘드로이틴 황산 또는 그 염 등은 통상 포유 동물이나 어류로부터 정제하여 사용할 수 있다.The polymeric polysaccharide may be any material as long as it can be incorporated into cosmetics, and examples thereof include hydroxyethyl cellulose, xanthan gum, sodium hyaluronate, chondroitin sulfate or salts thereof (sodium salt, etc.). For example, chondroitin sulfate or a salt thereof can be used after being purified from mammals or fish.
스핑고 지질로서는 화장품에 배합 가능한 것이라면 어떠한 것이라도 되지만, 예를 들어 세라미드, 피토스핑고신, 스핑고당지질 등을 들 수 있다. 스핑고 지질은 통상 포유류, 어류, 패류, 효모 또는 식물 등으로부터 통상의 방법에 의해 정제하거나 화학 합성법에 의해 취득할 수 있다.Any sphingolipid can be used as long as it can be incorporated into cosmetics, and examples thereof include ceramide, phytosphingosine, and sphingoglycolipid. Sphingolipids can be purified by conventional methods or obtained by chemical synthesis from mammals, fish, shellfish, yeast, or plants.
본 발명의 화장료 조성물에는 상기 필수 성분과 더불어 필요에 따라 통상 화장품에 배합되는 다른 성분을 배합해도 된다.In the cosmetic composition of the present invention, in addition to the above essential ingredients, other ingredients normally formulated in cosmetics may be blended as necessary.
이외에 첨가해도 되는 배합 성분으로서는 유지 성분, 보습제, 에몰리엔트제, 계면 활성제, 유기 및 무기 안료, 유기 분체, 자외선 흡수제, 방부제, 살균제, 산화 방지제, 식물 추출물, pH 조정제, 알콜, 색소, 향료, 혈행 촉진제, 냉감제, 제한(制汗)제, 정제수 등을 들 수 있다.Other ingredients that may be added include fats and oils, humectants, emollients, surfactants, organic and inorganic pigments, organic powders, ultraviolet absorbers, preservatives, bactericides, antioxidants, plant extracts, pH adjusters, alcohols, pigments, fragrances, A blood circulation accelerator, a cooling agent, an antiperspirant, purified water, etc. are mentioned.
유지 성분으로서는 에스테르계 유지, 탄화수소계 유지, 실리콘계 유지, 불소계 유지, 동물 유지, 식물 유지 등을 들 수 있다.Examples of the oil and fat component include ester oils, hydrocarbon oils, silicone oils, fluorine oils, animal fats and vegetable oils.
에스테르계 유지로서는 트리2-에틸헥산산글리세릴, 2-에틸헥산산세틸, 미리스틴산이소프로필, 미리스틴산부틸, 팔미틴산이소프로필, 스테아르산에틸, 팔미틴산옥틸, 이소스테아르산이소세틸, 스테아르산부틸, 리놀레산에틸, 리놀레산이소프로필, 올레인산에틸, 미리스틴산이소세틸, 미리스틴산이소스테아릴, 팔미틴산이소스테아릴, 미리스틴산옥틸도데실, 이소스테아르산이소세틸, 세바신산디에틸, 아디핀산디이소프로필, 네오펜탄산이소알킬, 트리(카프릴, 카프린산)글리세릴, 트리2-에틸헥산산트리메틸롤프로판, 트리이소스테아르산트리메틸롤프로판, 테트라2-에틸헥산산펜타엘리슬리톨, 카프릴산세틸, 라우린산데실, 라우린산헥실, 미리스틴산데실, 미리스틴산미리스틸, 미리스틴산세틸, 스테아르산스테아릴, 올레인산데실, 리시노올레인산세틸, 라우린산이소스테아릴, 미리스틴산이소트리데실, 팔미틴산이소세틸, 스테아르산옥틸, 스테아르산이소세틸, 올레인산이소데실, 올레인산옥틸도데실, 리놀레산옥틸도데실, 이소스테아르산이소프로필, 2-에틸헥산산세토스테아릴, 2-에틸헥산산스테아릴, 이소스테아르산헥실, 디옥탄산에틸렌글리콜, 디올레인산에틸렌글리콜, 디카프린산프로필렌글리콜, 디(카프릴,카프린산)프로필렌글리콜, 디카프릴산프로필렌글리콜, 디카프린산네오펜틸글리콜, 디옥탄산네오펜틸글리콜, 트리카프릴산글리세릴, 트리운데실산글리세릴, 트리이소팔미틴산글리세릴, 트리이소스테아르산글리세릴, 네오펜탄산옥틸도데실, 옥탄산이소스테아릴, 이소노난산옥틸, 네오데칸산헥실데실, 네오데칸산옥틸도데실, 이소스테아르산이소세틸, 이소스테아르산이소스테아릴, 이소스테아르산옥틸데실, 폴리글리세린올레인산에스테르, 폴리글리세린이소스테아르산에스테르, 시트르산트리이소세틸, 시트르산트리이소알킬, 시트르산트리이소옥틸, 락트산라우릴, 락트산미리스틸, 락트산세틸, 락트산옥틸데실, 시트르산트리에틸, 시트르산아세틸트리에틸, 시트르산아세틸트리부틸, 시트르산트리옥틸, 말산디이소스테아릴, 히드록시스테아르산 2-에틸헥실, 숙신산디2-에틸헥실, 아디핀산디이소부틸, 세바신산디이소프로필, 세바신산디옥틸, 스테아르산콜레스테릴, 이소스테아르산콜레스테릴, 히드록시스테아르산콜레스테릴, 올레인산콜레스테릴, 올레인산디히드로콜레스테릴, 이소스테아르산피트스테릴, 올레인산피트스테릴, 12-스테알로일히드록시스테아르산이소세틸, 12-스테알로일히드록시스테아르산스테아릴, 12-스테알로일히드록시스테아르산이소스테아릴 등의 에스테르계 등을 들 수 있다.Examples of ester oils include glyceryl tri-2-ethylhexanoate, cetyl 2-ethylhexanoate, isopropyl myristate, butyl myristate, isopropyl palmitate, ethyl stearate, octyl palmitate, isocetyl isostearate, and stearic acid. Butyl, ethyl linoleate, isopropyl linoleate, ethyl oleate, isocetyl myristate, isostearyl myristate, isostearyl palmitate, octyldodecyl myristate, isocetyl isostearate, diethyl sebacate, adipine Diisopropyl acid, isoalkyl neopentanoate, tri(capryl, capric acid) glyceryl, trimethylolpropane tri2-ethylhexanoate, trimethylolpropane triisostearate, pentaelislitol tetra2-ethylhexanoate , Cetyl caprylate, decyl laurate, hexyl laurate, decyl myristate, myristyl myristate, cetyl myristate, stearyl stearate, decyl oleate, cetyl ricinooleate, isostea laurate Lil, isotridecyl myristate, isocetyl palmitate, octyl stearate, isocetyl stearate, isodecyl oleate, octyldodecyl oleate, octyldodecyl linoleate, isopropyl isostearate, 2-ethylhexanoate Aryl, 2-ethyl stearyl hexanoate, hexyl isostearate, ethylene glycol dioctanoate, ethylene glycol dioleate, propylene glycol dicaprate, di(caprylic, capric acid) propylene glycol, propylene glycol dicaprylate, dicap Neopentyl glycol prinate, neopentyl glycol dioctanoate, glyceryl tricaprylate, glyceryl triundecylate, glyceryl triisopalmitate, glyceryl triisostearate, octyldodecyl neopentanoate, isostearyl octanoate , Octyl isononanoate, hexyldecyl neodecanoate, octyldodecyl neodecanoate, isocetyl isostearate, isostearyl isostearate, octyldecyl isostearate, polyglycerin oleate, polyglycerin isostearate, Triisocetyl citrate, triisoalkyl citrate, triisooctyl citrate, lauryl lactate, myristyl lactate, cetyl lactate, octyldecyl lactate, triethyl citrate, acetyltriethyl citrate, acetyltributyl citrate, trioctyl citrate, dimalate Isostearyl, 2-ethylhexyl hydroxystearate, di2-ethylhexyl succinate, diisobutyl adipate, diisopropyl sebacate, dioctyl sebacate, cholesteryl stearate, cholesteryl isostearate, Cholesteryl Hydroxystearate, Cholesteryl Oleate, Dihydrocholesteryl Oleate, Physteryl Isostearate, Physteryl Oleate, Isocetyl 12-stealoylhydroxystearate, 12-stealoyylhydro and esters such as stearyl oxystearate and isostearyl 12-stealoylhydroxystearate.
탄화 수소계 유지로서는 스쿠알렌, 유동 파라핀, 알파-올레핀올리고머, 이소파라핀, 세레신, 파라핀, 유동 이소파라핀, 폴리부덴, 마이크로크리스탈린왁스, 와셀린 등의 탄화 수소계 유지 등을 들 수 있다.Examples of hydrocarbon-based fats and oils include hydrocarbon-based fats and oils such as squalene, liquid paraffin, alpha-olefin oligomer, isoparaffin, ceresin, paraffin, liquid isoparaffin, polybuden, microcrystalline wax, and vaseline.
실리콘계 유지로서는 폴리메틸실리콘, 메틸페닐실리콘, 메틸시클로폴리실록산, 옥타메틸폴리실록산, 데카메틸폴리실록산, 도데카메틸시클로실록산, 디메틸실록산ㆍ메틸세틸옥시실록산 공중합체, 디메틸실록산ㆍ메틸스테알록시실록산 공중합체, 알킬 변성 실리콘유, 아미노 변성 실리콘유 등을 들 수 있다.Examples of silicone oils include polymethylsilicone, methylphenylsilicone, methylcyclopolysiloxane, octamethylpolysiloxane, decamethylpolysiloxane, dodecamethylcyclosiloxane, dimethylsiloxane/methylcetyloxysiloxane copolymer, dimethylsiloxane/methylstealoxysiloxane copolymer, alkyl Modified silicone oil, amino modified silicone oil, etc. are mentioned.
불소계 유지로서는 퍼플루오로폴리에테르 등을 들 수 있다.Examples of fluorine-based fats and oils include perfluoropolyether and the like.
동물 또는 식물 유지로서는 아보카도유, 아르몬드유, 올리브유, 참깨유, 쌀겨유, 새플라워유, 대두유, 옥수수유, 유채유, 행인(杏仁)유, 팜핵유, 팜유, 피마자유, 해바라기유, 포도종자유, 면실유, 야자유, 쿠쿠이너트유, 소맥배아유, 쌀 배아유, 시아버터, 월견초유, 마커데이미아너트유, 메도홈유, 난황유, 우지(牛脂), 마유, 밍크유, 오렌지라피유, 호호바유, 캔데리러왁스, 카르나바왁스, 액상 라놀린, 경화피마자유 등의 동물 또는 식물 유지를 들 수 있다.Animal or vegetable oils include avocado oil, almond oil, olive oil, sesame oil, rice bran oil, birdflower oil, soybean oil, corn oil, rapeseed oil, algae oil, palm kernel oil, palm oil, castor oil, sunflower oil, grape seed oil , cottonseed oil, palm oil, kukui nut oil, wheat germ oil, rice germ oil, shea butter, moonshine colostrum, marker damian nut oil, meadowsweet oil, egg yolk oil, beef tallow, horse oil, mink oil, orange raffia oil, jojoba oil , animal or plant fats and oils such as candelilla wax, carnaba wax, liquid lanolin, and hydrogenated castor oil.
보습제로서는 수용성 저분자 보습제, 지용성 분자 보습제, 수용성 고분자, 지용성 고분자 등을 들 수 있다.Examples of the moisturizer include water-soluble low-molecular moisturizers, fat-soluble molecular moisturizers, water-soluble polymers, and oil-soluble polymers.
수용성 저분자 보습제로서는 세린, 글루타민, 솔비톨, 만니톨, 피롤리돈-카르복실산나트륨, 글리세린, 프로필렌글리콜, 1,3-부틸렌글리콜, 에틸렌글리콜, 폴리에틸렌글리콜B(중합도 n=2 이상), 폴리프로필렌글리콜(중합도 n=2 이상), 폴리글리세린B(중합도 n=2 이상), 락트산, 락트산염 등을 들 수 있다.Examples of water-soluble low-molecular moisturizers include serine, glutamine, sorbitol, mannitol, pyrrolidone-sodium carboxylate, glycerin, propylene glycol, 1,3-butylene glycol, ethylene glycol, polyethylene glycol B (polymerization degree n = 2 or more), polypropylene Glycol (polymerization degree n = 2 or more), polyglycerol B (polymerization degree n = 2 or more), lactic acid, lactate, etc. are mentioned.
지용성 저분자 보습제로서는 콜레스테롤, 콜레스테롤에스테르 등을 들 수 있다.Cholesterol, cholesterol ester, etc. are mentioned as a fat-soluble low-molecular moisturizer.
수용성 고분자로서는 카르복시비닐폴리머, 폴리아스파라긴산염, 트라가칸트, 크산탄검, 메틸셀룰로오스, 히드록시메틸셀룰로오스, 히드록시에틸셀룰로오스, 히드록시프로필셀룰로오스, 카르복시메틸셀룰로오스, 수용성 키틴, 키토산, 덱스트린 등을 들 수 있다.Examples of water-soluble polymers include carboxyvinyl polymer, polyaspartate, tragacanth, xanthan gum, methyl cellulose, hydroxymethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, carboxymethyl cellulose, water-soluble chitin, chitosan, dextrin, and the like. can
지용성 고분자로서는 폴리비닐피롤리돈ㆍ에이코센 공중합체, 폴리비닐피롤리돈ㆍ헥사데센 공중합체, 니트로셀룰로오스, 덱스트린지방산에스테르, 고분자 실리콘 등을 들 수 있다.Examples of the fat-soluble polymer include polyvinylpyrrolidone/eicosene copolymer, polyvinylpyrrolidone/hexadecene copolymer, nitrocellulose, dextrin fatty acid ester, and high molecular silicone.
에몰리엔트제로서는 장쇄아실글루타민산콜레스테릴에스테르, 히드록시스테아르산콜레스테릴, 12-히드록시스테아르산, 스테아르산, 로진산, 라놀린지방산콜레스테릴에스테르 등을 들 수 있다.Examples of the emollient agent include long-chain acyl glutamic acid cholesteryl ester, hydroxystearic acid cholesteryl, 12-hydroxystearic acid, stearic acid, rosin acid, lanolin fatty acid cholesteryl ester, and the like.
계면 활성제로서는 비이온성 계면 활성제, 음이온성 계면 활성제, 양이온성 계면 활성제, 양성 계면 활성제 등을 들 수 있다.Examples of the surfactant include nonionic surfactants, anionic surfactants, cationic surfactants, and amphoteric surfactants.
비이온성 계면 활성제로서는 자기 유화형 모노스테아르산글리세린, 프로필렌글리콜지방산에스테르, 글리세린지방산에스테르, 폴리글리세린지방산에스테르, 솔비탄지방산에스테르, POE(폴리옥시에틸렌)솔비탄지방산에스테르, POE 솔비트지방산에스테르, POE 글리세린지방산에스테르, POE 알킬에테르, POE 지방산에스테르, POE 경화피마자유, POE 피마자유, POEㆍPOP(폴리옥시에틸렌ㆍ폴리옥시프로필렌) 공중합체, POEㆍPOP 알킬에테르, 폴리에테르변성실리콘, 라우린산알카놀아미드, 알킬아민옥시드, 수소첨가대두인지질 등을 들 수 있다.Nonionic surfactants include self-emulsifying glycerin monostearate, propylene glycol fatty acid esters, glycerin fatty acid esters, polyglycerin fatty acid esters, sorbitan fatty acid esters, POE (polyoxyethylene) sorbitan fatty acid esters, POE sorbitan fatty acid esters, POE Glycerin fatty acid ester, POE alkyl ether, POE fatty acid ester, POE hydrogenated castor oil, POE castor oil, POE·POP (polyoxyethylene·polyoxypropylene) copolymer, POE·POP alkyl ether, polyether modified silicone, lauric acid alkanolamides, alkylamine oxides, hydrogenated soybean phospholipids, and the like.
음이온성 계면 활성제로서는 지방산비누, 알파-아실술폰산염, 알킬술폰산염, 알킬알릴술폰산염, 알킬나프탈렌술폰산염, 알킬황산염, POE 알킬에테르황산염, 알킬아미드황산염, 알킬인산염, POE 알킬인산염, 알킬아미드인산염, 알킬로일알킬타우린염, N-아실아미노산염, POE 알킬에테르카르복실산염, 알킬술포숙신산염, 알킬술포아세트산나트륨, 아실화 가수분해 콜라겐펩티드염, 퍼플루오로알킬인산에스테르 등을 들 수 있다.Anionic surfactants include fatty acid soaps, alpha-acyl sulfonates, alkyl sulfonates, alkyl allyl sulfonates, alkyl naphthalene sulfonates, alkyl sulfates, POE alkyl ether sulfates, alkyl amide sulfates, alkyl phosphates, POE alkyl phosphates, and alkyl amide phosphates. , alkyloylalkyl taurine salts, N-acylamino acid salts, POE alkyl ether carboxylate salts, alkyl sulfosuccinic acid salts, sodium alkyl sulfoacetate, acylated hydrolyzed collagen peptide salts, perfluoroalkyl phosphate esters, and the like. .
양이온성 계면 활성제로서는 염화알킬트리메틸암모늄, 염화스테아릴트리메틸암모늄, 브롬화스테아릴트리메틸암모늄, 염화세토스테아릴트리메틸암모늄, 염화디스테아릴디메틸암모늄, 염화스테아릴디메틸벤질암모늄, 브롬화베헤닐트리메틸암모늄, 염화벤잘코늄, 스테아르산디에틸아미노에틸아미드, 스테아르산디메틸아미노프로필아미드, 라놀린 유도체 제 4급 암모늄염 등을 들 수 있다.As the cationic surfactant, alkyltrimethylammonium chloride, stearyltrimethylammonium chloride, stearyltrimethylammonium bromide, cetostearyltrimethylammonium chloride, distearyldimethylammonium chloride, stearyldimethylbenzylammonium chloride, behenyltrimethylammonium bromide, chloride Benzalkonium, stearic acid diethylaminoethylamide, stearic acid dimethylaminopropylamide, lanolin derivative quaternary ammonium salt, etc. are mentioned.
양성 계면 활성제로서는 카르복시베타인형, 아미드베타인형, 술포베타인형, 히드록시술포베타인형, 아미드술포베타인형, 포스포베타인형, 아미노카르복실산염형, 이미다졸린 유도체형, 아미드아민형 등의 양성 계면 활성제 등을 들 수 있다.Amphoteric surfactants include carboxybetaine type, amidebetaine type, sulfobetaine type, hydroxysulfobetaine type, amide sulfobetaine type, phosphobetaine type, aminocarboxylate type, imidazoline derivative type, amideamine type, etc. An amphoteric surfactant etc. are mentioned.
유기 및 무기 안료로서는 규산, 무수규산, 규산마그네슘, 탤크, 세리사이트, 마이카, 카올린, 벵갈라, 클레이, 벤토나이트, 티탄피막운모, 옥시염화비스무트, 산화지르코늄, 산화마그네슘, 산화아연, 산화티탄, 산화알루미늄, 황산칼슘, 황산바륨, 황산마그네슘, 탄산칼슘, 탄산마그네슘, 산화철, 군청, 산화크롬, 수산화크롬, 칼라민 및 이들의 복합체등의 무기 안료; 폴리아미드, 폴리에스테르, 폴리프로필렌, 폴리스티렌, 폴리우레탄, 비닐수지, 요소수지, 페놀수지, 불소수지, 규소수지, 아크릴수지, 멜라민수지, 에폭시수지, 폴리카보네이트수지, 디비닐벤젠ㆍ스티렌 공중합체, 실크파우더, 셀룰로오스, CI 피그먼트옐로우, CI 피그먼트오렌지 등의 유기 안료 및 이들의 무기 안료와 유기 안료의 복합 안료 등을 들 수 있다.As organic and inorganic pigments, silicic acid, silicic anhydride, magnesium silicate, talc, sericite, mica, kaolin, bengala, clay, bentonite, titanium-coated mica, bismuth oxychloride, zirconium oxide, magnesium oxide, zinc oxide, titanium oxide, aluminum oxide inorganic pigments such as calcium sulfate, barium sulfate, magnesium sulfate, calcium carbonate, magnesium carbonate, iron oxide, ultramarine blue, chromium oxide, chromium hydroxide, calamine and complexes thereof; Polyamide, polyester, polypropylene, polystyrene, polyurethane, vinyl resin, urea resin, phenolic resin, fluororesin, silicon resin, acrylic resin, melamine resin, epoxy resin, polycarbonate resin, divinylbenzene/styrene copolymer, organic pigments such as silk powder, cellulose, CI pigment yellow and CI pigment orange, and composite pigments of these inorganic pigments and organic pigments.
유기 분체로서는 스테아르산칼슘 등의 금속비누; 세틸린산아연나트륨, 라우릴린산아연, 라우릴린산칼슘 등의 알킬인산금속염; N-라우로일-베타-알라닌칼슘, N-라우로일-베타-알라닌아연, N-라우로일글리신칼슘 등의 아실아미노산 다가금속염; N-라우로일-타우린칼슘, N-팔미토일-타우린칼슘 등의 아미드술폰산 다가금속염; N-엡실론-라우로일-L-리진, N-엡실론-팔미토일리진, N-알파-파리토일올니틴, N-알파-라우로일아르기닌, N-알파-경화우지지방산아실아르기닌 등의 N-아실염기성아미노산; N-라우로일글리실글리신 등의 N-아실폴리펩티드; 알파-아미노카프릴산, 알파-아미노라우린산 등의 알파-아미노지방산; 폴리에틸렌, 폴리프로필렌, 나일론, 폴리메틸메타크릴레이트, 폴리스티렌, 디비닐벤젠ㆍ스티렌 공중합체, 사불화에틸렌 등을 들 수 있다.Examples of the organic powder include metal soaps such as calcium stearate; Alkyl phosphate metal salts, such as zinc sodium cetylrate, zinc laurylrate, and calcium laurylrate; polyvalent metal salts of acyl amino acids such as N-lauroyl-beta-alanine calcium, N-lauroyl-beta-alanine zinc, and N-lauroyl glycine calcium; polyvalent metal salts of amide sulfonic acids such as N-lauroyl-taurine calcium and N-palmitoyl-taurine calcium; N-epsilon-lauroyl-L-lysine, N-epsilon-palmitoylizine, N-alpha-paritoylolnithine, N-alpha-lauroylarginine, N-alpha-hardened beef fatty acid acylarginine, etc. -acyl basic amino acids; N-acyl polypeptides such as N-lauroylglycylglycine; alpha-amino fatty acids such as alpha-aminocaprylic acid and alpha-aminolauric acid; polyethylene, polypropylene, nylon, polymethyl methacrylate, polystyrene, divinylbenzene/styrene copolymer, tetrafluoroethylene, and the like.
자외선 흡수제로서는 파라아미노벤조산, 파라아미노벤조산에틸, 파라아미노벤조산아밀, 파라아미노벤조산옥틸, 살리실산에틸렌글리콜, 살리신산페닐, 살리신산옥틸, 살리신산벤질, 살리신산부틸페닐, 살리신산호모멘틸, 계피산벤질, 파라메톡시계피산-2-에톡시에틸, 파라메톡시계피산옥틸, 디파라메톡시계피산모노-2-에틸헥산글리세릴, 파라메톡시계피산이소프로필, 디이소프로필ㆍ디이소프로필계피산에스테르 혼합물, 우로카닌산, 우로카닌산에틸, 히드록시메톡시벤조페논, 히드록시메톡시벤조페논술폰산 및 그 염, 디히드록시메톡시벤조페논, 디히드록시메톡시벤조페논디술폰산나트륨, 디히드록시벤조페논, 테트라히드록시벤조페논, 4-tert-부틸-4'-메톡시디벤조일메탄, 2,4,6-트리아닐리노-p-(카르보-2'-에틸헥실-1'-옥시)-1,3,5-트리아진, 2-(2-히드록시-5-메틸페닐)벤조트리아졸 등을 들 수 있다.Examples of UV absorbers include para-aminobenzoic acid, ethyl para-aminobenzoate, amyl para-aminobenzoate, octyl para-aminobenzoate, ethylene glycol salicylate, phenyl salicylate, octyl salicylate, benzyl salicylate, butylphenyl salicylate, homomenthyl salicylate, and benzyl cinnamate. , paramethoxycinnamic acid-2-ethoxyethyl, paramethoxycinnamic acid octyl, diparamethoxycinnamic acid mono-2-ethylhexane glyceryl, paramethoxycinnamic acid isopropyl, diisopropyl-diisopropylcinnamic acid ester mixture, uro Cannic acid, ethyl urocanate, hydroxymethoxybenzophenone, hydroxymethoxybenzophenonesulfonic acid and its salts, dihydroxymethoxybenzophenone, dihydroxymethoxybenzophenone sodium disulfonate, dihydroxybenzophenone , tetrahydroxybenzophenone, 4-tert-butyl-4'-methoxydibenzoylmethane, 2,4,6-trianilino-p-(carbo-2'-ethylhexyl-1'-oxy)-1 ,3,5-triazine, 2-(2-hydroxy-5-methylphenyl)benzotriazole, etc. are mentioned.
살균제로서는 히노키티올, 트리클로산, 트리클로로히드록시디페닐에테르, 크로르헥시딘글루콘산염, 페녹시에탄올, 레조르신, 이소프로필메틸페놀, 아줄렌, 살리칠산, 진크필리티온, 염화벤잘코늄, 감광소 301 호, 모노니트로과이어콜나트륨, 운데시렌산 등을 들 수 있다.Bactericides include hinokitiol, triclosan, trichlorohydroxydiphenyl ether, chlorhexidine gluconate, phenoxyethanol, resorcin, isopropylmethylphenol, azulene, salicylic acid, zincophylthione, benzalkonium chloride, photosensitizer So No. 301, mononitroguacol sodium, undecyrenic acid, etc. are mentioned.
산화 방지제로서는 부틸히드록시아니솔, 갈릭산프로필, 엘리소르빈산 등을 들 수 있다.Examples of antioxidants include butylhydroxyanisole, propyl gallic acid, and elisorbic acid.
pH 조정제로서는 시트르산, 시트르산나트륨, 말산, 말산나트륨, 프말산, 프말산나트륨, 숙신산, 숙신산나트륨, 수산화나트륨, 인산일수소나트륨 등을 들 수 있다.Examples of the pH adjuster include citric acid, sodium citrate, malic acid, sodium malate, fumaric acid, sodium fumalate, succinic acid, sodium succinate, sodium hydroxide, and sodium monohydrogenphosphate.
알코올로서는 세틸알코올 등의 고급 알코올을 들 수 있다.Examples of alcohol include higher alcohols such as cetyl alcohol.
또한, 이외에 첨가해도 되는 배합 성분은 이에 한정되는 것은 아니며, 또, 상기 어느 성분도 본 발명의 목적 및 효과를 손상시키지 않는 범위 내에서 배합 가능하지만, 총중량에 대하여 0.01-5% 중량 백분율 또는 0.01-3% 중량 백분율로 배합될 수 있다.In addition, the blending components that may be added are not limited to these, and any of the above ingredients can be blended within a range not impairing the objects and effects of the present invention, but 0.01 to 5% by weight percent or 0.01 to 3% based on the total weight. Can be formulated in % weight percentage.
본 발명의 제형이 로션, 페이스트, 크림 또는 겔인 경우에는 담체 성분으로서 동물섬유, 식물섬유, 왁스, 파라핀, 전분, 트라칸트, 셀룰로오스 유도체, 폴리에틸렌 글리콜, 실리콘, 벤토나이트, 실리카, 탈크 또는 산화아연 등이 이용될 수 있다.When the formulation of the present invention is a lotion, paste, cream or gel, animal fiber, vegetable fiber, wax, paraffin, starch, tracanth, cellulose derivative, polyethylene glycol, silicone, bentonite, silica, talc or zinc oxide as a carrier component can be used
본 발명의 제형이 파우더 또는 스프레이인 경우에는 담체 성분으로서 락토스, 탈크, 실리카, 알루미늄 히드록시드, 칼슘 실리케이트 또는 폴리아미드 파우더가 이용될 수 있고, 특히 스프레이인 경우에는 추가적으로 클로로플루오로히드로카본, 프로판/부탄 또는 디메틸 에테르와 같은 추진체를 포함할 수 있다.When the formulation of the present invention is a powder or spray, lactose, talc, silica, aluminum hydroxide, calcium silicate or polyamide powder may be used as a carrier component, and in particular, in the case of a spray, additional chlorofluorohydrocarbon, propane / May contain a propellant such as butane or dimethyl ether.
본 발명의 제형이 용액 또는 유탁액의 경우에는 담체 성분으로서 용매, 용매화제 또는 유탁화제가 이용되고, 예컨대 물, 에탄올, 이소프로판올, 에틸 카보네이트, 에틸 아세테이트, 벤질 알코올, 벤질 벤조에이트, 프로필렌 글리콜, 1,3-부틸글리콜 오일, 글리세롤 지방족 에스테르, 폴리에틸렌 글리콜 또는 소르비탄의 지방산 에스테르가 있다.When the formulation of the present invention is a solution or emulsion, a solvent, solvating agent or emulsifying agent is used as a carrier component, such as water, ethanol, isopropanol, ethyl carbonate, ethyl acetate, benzyl alcohol, benzyl benzoate, propylene glycol, 1 ,3-butyl glycol oil, fatty acid esters of glycerol, polyethylene glycol or sorbitan.
본 발명의 제형이 현탁액인 경우에는 담체 성분으로서 물, 에탄올 또는 프로필렌 글리콜과 같은 액상 희석제, 에톡실화 이소스테아릴 알코올, 폴리옥시에틸렌 소르비톨 에스테르 및 폴리옥시에틸렌 소르비탄 에스테르와 같은 현탁제, 미소결정성 셀룰로오스, 알루미늄 메타히드록시드, 벤토나이트, 아가 또는 트라칸트 등이 이용될 수 있다.When the formulation of the present invention is a suspension, as a carrier component, a liquid diluent such as water, ethanol or propylene glycol, an ethoxylated isostearyl alcohol, a suspending agent such as polyoxyethylene sorbitol ester and polyoxyethylene sorbitan ester, microcrystalline Cellulose, aluminum metahydroxide, bentonite, agar or tracanth and the like may be used.
본 발명의 제형이 계면-활성제 함유 클렌징인 경우에는 담체 성분으로서 지방족 알코올 설페이트, 지방족 알코올 에테르 설페이트, 설포숙신산 모노에스테르, 이세티오네이트, 이미다졸리늄 유도체, 메틸타우레이트, 사르코시네이트, 지방산 아미드 에테르 설페이트, 알킬아미도베타인, 지방족 알코올, 지방산 글리세리드, 지방산 디에탄올아미드, 식물성 유, 리놀린 유도체 또는 에톡실화 글리세롤 지방산 에스테르 등이 이용될 수 있다.When the formulation of the present invention is surfactant-containing cleansing, as carrier components, aliphatic alcohol sulfate, aliphatic alcohol ether sulfate, sulfosuccinic acid monoester, isethionate, imidazolinium derivative, methyl taurate, sarcosinate, fatty acid amide Ether sulfates, alkylamidobetaines, fatty alcohols, fatty acid glycerides, fatty acid diethanolamides, vegetable oils, linolin derivatives, or ethoxylated glycerol fatty acid esters may be used.
본 발명의 다른 양태로서, 본 발명은 소인제(Aeonium sediforium) 추출물을 유효성분으로 포함하는, 항산화용; 항염증용; 모공축소용; 또는 주름예방 및 개선용 식품 조성물을 제공한다.As another aspect of the present invention, the present invention soinje ( Aeonium sediforium ) For antioxidant, comprising an extract as an active ingredient; for anti-inflammatory use; for pore reduction; Or it provides a food composition for preventing and improving wrinkles.
본 발명에 있어서, “식품”이란 영양소를 한 가지 또는 그 이상 함유하고 있는 천연물 또는 가공품을 의미하며, 바람직하게는 어느 정도의 가공 공정을 거쳐 직접 먹을 수 있는 상태가 된 것을 의미하며, 통상적인 의미로서, 건강기능성 식품, 음료, 식품 첨가제 및 음료 첨가제 등을 모두 포함하는 의미이다.In the present invention, "food" means a natural product or processed product containing one or more nutrients, preferably means a state that can be eaten directly through a certain degree of processing process, and usually means As, it means to include all health functional foods, beverages, food additives and beverage additives.
본 발명에 있어서, 상기 식품 조성물은 건강기능성 식품 조성물일 수 있으나, 이에 제한되지 않는다.In the present invention, the food composition may be a health functional food composition, but is not limited thereto.
본 발명에 있어서, 상기 “건강기능성 식품(functional food)”이란, 특정보건용 식품(food for special health use, FoSHU)과 동일한 용어로, 영양 공급 외에도 생체조절기능이 효율적으로 나타나도록 가공된 의학, 의료효과가 높은 식품을 의미하며, 정제, 캡슐제, 환제, 과립제, 분말, 액제, 편상(flake), 페이스트, 시럽제, 겔, 젤리, 바(bar), 또는 필름 제형으로 제조될 수 있다. 여기서 "기능성"이라 함은 인체의 구조 및 기능에 대하여 영양소를 조절하거나 생리학적 작용 등과 같은 보건용도에 유용한 효과를 얻는 것을 의미한다.In the present invention, the "functional food" is the same term as food for special health use (FoSHU), medicine processed to efficiently display bioregulatory functions in addition to nutritional supply, It means a food with high medical effect, and can be manufactured into tablets, capsules, pills, granules, powders, liquids, flakes, pastes, syrups, gels, jellies, bars, or film formulations. Here, "functionality" means obtaining useful effects for health purposes such as regulating nutrients for the structure and function of the human body or physiological functions.
본 발명의 소인제 추출물을 식품 첨가물로 사용할 경우, 이를 그대로 첨가하거나 다른 식품 또는 식품 성분과 함께 사용할 수 있고, 통상적인 방법에 따라 적절하게 사용할 수 있다. 유효성분의 혼합양은 사용 목적(예방, 건강 또는 치료적 처치)에 따라 적합하게 결정될 수 있다. 일반적으로, 식품 또는 음료의 제조시 본 발명의 소인제 추출물은 원료에 대하여 15 중량% 이하, 또는 10 중량% 이하의 양으로 첨가될 수 있다. 그러나, 건강 및 위생을 목적으로 하거나 또는 건강 조절을 목적으로 하는 장기간의 섭취의 경우 상기 양은 상기 범위 이하일 수 있으며, 안전성 면에서 아무런 문제가 없기 때문에 유효성분은 상기 범위 이상의 양으로도 사용될 수 있다.When using the soinje extract of the present invention as a food additive, it may be added as it is or used together with other foods or food ingredients, and may be appropriately used according to conventional methods. The mixing amount of the active ingredient may be appropriately determined according to the purpose of use (prevention, health or therapeutic treatment). In general, when preparing food or beverage, the extract of the present invention may be added in an amount of 15% by weight or less, or 10% by weight or less based on the raw material. However, in the case of long-term intake for the purpose of health and hygiene or health control, the amount may be less than the above range, and since there is no problem in terms of safety, the active ingredient may be used in an amount greater than the above range.
상기 식품의 종류에는 특별한 제한은 없다. 상기 물질을 첨가할 수 있는 식품의 예로는 육류, 소세지, 빵, 쵸코렛, 캔디류, 스넥류, 과자류, 피자, 라면, 기타 면류, 껌류, 아이스크림류를 포함한 낙농제품, 각종 스프, 음료수, 차, 드링크제, 알콜 음료 및 비타민 복합제 등이 있으며, 통상적인 의미에서의 건강기능식품을 모두 포함한다.There is no particular limitation on the type of food. Examples of foods to which the above substances can be added include meat, sausages, bread, chocolates, candies, snacks, confectionery, pizza, ramen, other noodles, gums, dairy products including ice creams, various soups, beverages, tea, drinks, There are alcoholic beverages and vitamin complexes, and includes all health functional foods in a conventional sense.
본 발명에 따른 건강음료 조성물은 통상의 음료와 같이 여러 가지 향미제 또는 천연 탄수화물 등을 추가 성분으로서 함유할 수 있다. 상술한 천연 탄수화물은 포도당 및 과당과 같은 모노사카라이드, 말토오스 및 수크로오스와 같은 디사카라이드, 덱스트린 및 시클로덱스트린과 같은 폴리사카라이드, 및 자일리톨, 소르비톨 및 에리트리톨 등의 당알콜이다. 감미제로서는 타우마틴, 스테비아 추출물과 같은 천연 감미제나, 사카린, 아스파르탐과 같은 합성 감미제 등을 사용할 수 있다. 상기 천연 탄수화물의 비율은 본 발명의 조성물 100 mL당 일반적으로 약 0.01-0.20g, 또는 약 0.04-0.10g 이다.The health beverage composition according to the present invention may contain various flavoring agents or natural carbohydrates as additional components, like conventional beverages. The aforementioned natural carbohydrates are monosaccharides such as glucose and fructose, disaccharides such as maltose and sucrose, polysaccharides such as dextrins and cyclodextrins, and sugar alcohols such as xylitol, sorbitol and erythritol. As the sweetener, natural sweeteners such as thaumatin and stevia extract, or synthetic sweeteners such as saccharin and aspartame may be used. The proportion of the natural carbohydrate is generally about 0.01-0.20 g, or about 0.04-0.10 g per 100 mL of the composition of the present invention.
상기 외에 본 발명의 조성물은 여러 가지 영양제, 비타민, 전해질, 풍미제, 착색제, 펙트산 및 그의 염, 알긴산 및 그의 염, 유기산, 보호성 콜로이드 증점제, pH 조절제, 안정화제, 방부제, 글리세린, 알콜, 탄산 음료에 사용되는 탄산화제 등을 함유할 수 있다. 그 밖에 본 발명의 조성물은 천연 과일쥬스, 과일쥬스 음료 및 야채 음료의 제조를 위한 과육을 함유할 수 있다. 이러한 성분은 독립적으로 또는 조합하여 사용할 수 있다. 이러한 첨가제의 비율은 크게 중요하진 않지만 본 발명의 조성물 100 중량부 당 0.01-0.20 중량부의 범위에서 선택되는 것이 일반적이다.In addition to the above, the composition of the present invention contains various nutrients, vitamins, electrolytes, flavors, colorants, pectic acid and its salts, alginic acid and its salts, organic acids, protective colloidal thickeners, pH adjusters, stabilizers, preservatives, glycerin, alcohols, A carbonation agent used in carbonated beverages and the like may be contained. In addition, the composition of the present invention may contain fruit flesh for preparing natural fruit juice, fruit juice beverages and vegetable beverages. These components may be used independently or in combination. The ratio of these additives is not critical, but is generally selected in the range of 0.01-0.20 parts by weight per 100 parts by weight of the composition of the present invention.
상기 건강기능성 식품은 이너뷰티 푸드(inner beauty) 형태로 섭취함으로써 더욱 우수한 효과를 갖는 장점을 가질 수 있다. 상기 이너뷰티(inner beauty)는 '먹는 화장품 또는 뷰티 푸드'로 일컬어지는 푸드로, 피부에 좋은 여러 가지 성분을 몸속으로 흡수시켜 피부 체질을 건강하게 바꾸는 식품을 지칭하며, 피부 타입에 맞는 화장품을 고르듯 피부 컨디션과 라이프스타일을 고려해 개개인에게 맞는 이너뷰티 푸드를 선택하여 섭취할 수 있다. 예를 들면, 상기 화장료 조성물을 포함하는 화장품과 상기 소인제 추출물을 포함하는 이너뷰티 푸드를 혼용할 경우, 화장품 또는 약제만 사용하는 것에 비해 효과가 월등히 높아져 더욱 효과적인 항산화, 항염증, 모공축소, 주름예방 또는 개선 효과를 볼 수 있는 장점을 가질 수 있다.The health functional food may have an advantage of having a more excellent effect by ingesting it in the form of inner beauty food. The inner beauty refers to food referred to as 'eating cosmetics or beauty food', which absorbs various ingredients good for the skin into the body and changes the skin constitution to a healthy one. You can select and consume the inner beauty food that suits your individual skin condition and lifestyle. For example, when cosmetics containing the cosmetic composition and inner beauty food containing the soinje extract are mixed, the effect is significantly higher than using only cosmetics or drugs, resulting in more effective antioxidant, anti-inflammatory, pore reduction, and wrinkles. It may have the advantage of seeing a preventive or ameliorative effect.
또한, 본 발명은 소인제(Aeonium sediforium) 추출물을 유효성분으로 포함하는, 항산화용; 또는 항염증용 약학적 조성물을 제공한다.In addition, the present invention soinje ( Aeonium sediforium ) For antioxidant, including an extract as an active ingredient; Or it provides a pharmaceutical composition for anti-inflammatory.
본 발명에 있어서 “항염증”은 염증을 억제하거나 감소시키는 작용을 의미하며, 염증성 질환의 예방, 개선, 또는 치료 활성을 포함하는 의미로 사용될 수 있다. 상기 염증성 질환은 천식, 알레르기성 및 비-알레르기성 비염, 위염, 장염, 궤양성 위염, 신장염, 간염, 만성 폐쇄성 폐질환, 폐섬유종, 과민성 대장증후군, 염증성 통증, 편두통, 두통, 허리 통증, 섬유 근육통, 근막 질환, 바이러스 감염(예컨대, C형 감염), 박테리아 감염, 곰팡이 감염, 화상, 외과적 또는 치과적 수술에 의한 상처, 관절염, 류머티스성 관절염, 강직성 척추염, 호지킨병, 췌장염, 결막염, 홍채염, 공막염, 포도막염, 피부염(아토피성 피부염 포함), 습진, 및 다발성 경화증으로 이루어진 군으로부터 선택되는 하나 이상일 수 있으나, 이에 제한되지 않는다.In the present invention, “anti-inflammatory” refers to an action of suppressing or reducing inflammation, and may be used to include prevention, improvement, or therapeutic activity of inflammatory diseases. The inflammatory diseases include asthma, allergic and non-allergic rhinitis, gastritis, enteritis, ulcerative gastritis, nephritis, hepatitis, chronic obstructive pulmonary disease, pulmonary fibrosis, irritable bowel syndrome, inflammatory pain, migraine, headache, back pain, fibrosis myalgia, myofascial disease, viral infection (e.g. hepatitis C infection), bacterial infection, fungal infection, burn, surgical or dental injury, arthritis, rheumatoid arthritis, ankylosing spondylitis, Hodgkin's disease, pancreatitis, conjunctivitis, It may be one or more selected from the group consisting of iritis, scleritis, uveitis, dermatitis (including atopic dermatitis), eczema, and multiple sclerosis, but is not limited thereto.
본 발명에 따른 약학적 조성물은 약학적 조성물의 제조에 통상적으로 사용하는 적절한 담체, 부형제 및 희석제를 더 포함할 수 있다. 상기 부형제는 예를 들어, 희석제, 결합제, 붕해제, 활택제, 흡착제, 보습제, 필름-코팅 물질, 및 제어방출첨가제로 이루어진 군으로부터 선택된 하나 이상일 수 있다. The pharmaceutical composition according to the present invention may further include suitable carriers, excipients and diluents commonly used in the manufacture of pharmaceutical compositions. The excipient may be, for example, one or more selected from the group consisting of a diluent, a binder, a disintegrant, a lubricant, an adsorbent, a moisturizer, a film-coating material, and a controlled release additive.
본 발명에 따른 약학적 조성물은, 각각 통상의 방법에 따라 산제, 과립제, 서방형 과립제, 장용과립제, 액제, 점안제, 엘실릭제, 유제, 현탁액제, 주정제, 트로키제, 방향수제, 리모나아데제, 정제, 서방형정제, 장용정제, 설하정, 경질캅셀제, 연질캅셀제, 서방캅셀제, 장용캅셀제, 환제, 틴크제, 연조엑스제, 건조엑스제, 유동엑스제, 주사제, 캡슐제, 관류액, 경고제, 로션제, 파스타제, 분무제, 흡입제, 패취제, 멸균주사용액, 또는 에어로졸 등의 외용제 등의 형태로 제형화하여 사용될 수 있으며, 상기 외용제는 크림, 젤, 패치, 분무제, 연고제, 경고제, 로션제, 리니멘트제, 파스타제 또는 카타플라스마제 등의 제형을 가질 수 있다.The pharmaceutical compositions according to the present invention are powders, granules, sustained-release granules, enteric granules, solutions, eye drops, elsilic agents, emulsions, suspensions, spirits, troches, perfumes, and limonadese, respectively, according to conventional methods. , tablets, sustained-release tablets, enteric tablets, sublingual tablets, hard capsules, soft capsules, sustained-release capsules, enteric capsules, pills, tinctures, soft extracts, dry extracts, fluid extracts, injections, capsules, perfusate, It can be formulated and used in the form of an external agent such as a warning agent, lotion, pasta agent, spray, inhalant, patch, sterile injection solution, or aerosol, and the external agent is a cream, gel, patch, spray, ointment, warning agent , lotion, liniment, pasta, or cataplasma may have formulations such as the like.
본 발명에 따른 약학적 조성물에 포함될 수 있는 담체, 부형제 및 희석제로는 락토즈, 덱스트로즈, 수크로스, 올리고당, 솔비톨, 만니톨, 자일리톨, 에리스리톨, 말티톨, 전분, 아카시아 고무, 알지네이트, 젤라틴, 칼슘 포스페이트, 칼슘 실리케이트, 셀룰로즈, 메틸 셀룰로오스, 미정질 셀룰로오스, 폴리비닐 피롤리돈, 물, 메틸히드록시벤조에이트, 프로필히드록시벤조에이트, 탈크, 마그네슘 스테아레이트 및 광물유를 들 수 있다. Carriers, excipients and diluents that may be included in the pharmaceutical composition according to the present invention include lactose, dextrose, sucrose, oligosaccharide, sorbitol, mannitol, xylitol, erythritol, maltitol, starch, acacia gum, alginate, gelatin, calcium phosphate, calcium silicate, cellulose, methyl cellulose, microcrystalline cellulose, polyvinyl pyrrolidone, water, methylhydroxybenzoate, propylhydroxybenzoate, talc, magnesium stearate and mineral oil.
제제화할 경우에는 보통 사용하는 충진제, 증량제, 결합제, 습윤제, 붕해제, 계면활성제 등의 희석제 또는 부형제를 사용하여 조제된다.When formulated, it is prepared using diluents or excipients such as commonly used fillers, extenders, binders, wetting agents, disintegrants, and surfactants.
본 발명에 따른 정제, 산제, 과립제, 캡슐제, 환제, 트로키제의 첨가제로 옥수수전분, 감자전분, 밀전분, 유당, 백당, 포도당, 과당, 디-만니톨, 침강탄산칼슘, 합성규산알루미늄, 인산일수소칼슘, 황산칼슘, 염화나트륨, 탄산수소나트륨, 정제 라놀린, 미결정셀룰로오스, 덱스트린, 알긴산나트륨, 메칠셀룰로오스, 카르복시메칠셀룰로오스나트륨, 카올린, 요소, 콜로이드성실리카겔, 히드록시프로필스타치, 히드록시프로필메칠셀룰로오스(HPMC), HPMC 1928, HPMC 2208, HPMC 2906, HPMC 2910, 프로필렌글리콜, 카제인, 젖산칼슘, 프리모젤 등 부형제; 젤라틴, 아라비아고무, 에탄올, 한천가루, 초산프탈산셀룰로오스, 카르복시메칠셀룰로오스, 카르복시메칠셀룰로오스칼슘, 포도당, 정제수, 카제인나트륨, 글리세린, 스테아린산, 카르복시메칠셀룰로오스나트륨, 메칠셀룰로오스나트륨, 메칠셀룰로오스, 미결정셀룰로오스, 덱스트린, 히드록시셀룰로오스, 히드록시프로필스타치, 히드록시메칠셀룰로오스, 정제쉘락, 전분호, 히드록시프로필셀룰로오스, 히드록시프로필메칠셀룰로오스, 폴리비닐알코올, 폴리비닐피롤리돈 등의 결합제가 사용될 수 있으며, 히드록시프로필메칠셀룰로오스, 옥수수전분, 한천가루, 메칠셀룰로오스, 벤토나이트, 히드록시프로필스타치, 카르복시메칠셀룰로오스나트륨, 알긴산나트륨, 카르복시메칠셀룰로오스칼슘, 구연산칼슘, 라우릴황산나트륨, 무수규산, 1-히드록시프로필셀룰로오스, 덱스트란, 이온교환수지, 초산폴리비닐, 포름알데히드처리 카제인 및 젤라틴, 알긴산, 아밀로오스, 구아르고무(Guar gum), 중조, 폴리비닐피롤리돈, 인산칼슘, 겔화전분, 아라비아고무, 아밀로펙틴, 펙틴, 폴리인산나트륨, 에칠셀룰로오스, 백당, 규산마그네슘알루미늄, 디-소르비톨액, 경질무수규산 등 붕해제; 스테아린산칼슘, 스테아린산마그네슘, 스테아린산, 수소화식물유(Hydrogenated vegetable oil), 탈크, 석송자, 카올린, 바셀린, 스테아린산나트륨, 카카오지, 살리실산나트륨, 살리실산마그네슘, 폴리에칠렌글리콜(PEG) 4000, PEG 6000, 유동파라핀, 수소첨가대두유(Lubri wax), 스테아린산알루미늄, 스테아린산아연, 라우릴황산나트륨, 산화마그네슘, 마크로골(Macrogol), 합성규산알루미늄, 무수규산, 고급지방산, 고급알코올, 실리콘유, 파라핀유, 폴리에칠렌글리콜지방산에테르, 전분, 염화나트륨, 초산나트륨, 올레인산나트륨, dl-로이신, 경질무수규산 등의 활택제가 사용될 수 있다.Corn starch, potato starch, wheat starch, lactose, sucrose, glucose, fructose, di-mannitol, precipitated calcium carbonate, synthetic aluminum silicate, phosphoric acid as additives for tablets, powders, granules, capsules, pills, and troches according to the present invention Calcium monohydrogen, calcium sulfate, sodium chloride, sodium bicarbonate, purified lanolin, microcrystalline cellulose, dextrin, sodium alginate, methylcellulose, sodium carboxymethylcellulose, kaolin, urea, colloidal silica gel, hydroxypropyl starch, hydroxypropylmethyl excipients such as cellulose (HPMC), HPMC 1928, HPMC 2208, HPMC 2906, HPMC 2910, propylene glycol, casein, calcium lactate, and Primogel; Gelatin, gum arabic, ethanol, agar powder, cellulose phthalate acetate, carboxymethyl cellulose, calcium carboxymethyl cellulose, glucose, purified water, sodium caseinate, glycerin, stearic acid, sodium carboxymethyl cellulose, sodium methyl cellulose, methyl cellulose, microcrystalline cellulose, dextrin Binders such as hydroxycellulose, hydroxypropyl starch, hydroxymethylcellulose, purified shellac, starch arc, hydroxypropylcellulose, hydroxypropylmethylcellulose, polyvinyl alcohol, and polyvinylpyrrolidone may be used, Hydroxypropyl Methyl Cellulose, Corn Starch, Agar Powder, Methyl Cellulose, Bentonite, Hydroxypropyl Starch, Sodium Carboxymethyl Cellulose, Sodium Alginate, Calcium Carboxymethyl Cellulose, Calcium Citrate, Sodium Lauryl Sulfate, Silicic Anhydride, 1-Hydroxy Propyl cellulose, dextran, ion exchange resin, polyvinyl acetate, formaldehyde-treated casein and gelatin, alginic acid, amylose, guar gum, sodium bicarbonate, polyvinylpyrrolidone, calcium phosphate, gelled starch, gum arabic, disintegrants such as amylopectin, pectin, sodium polyphosphate, ethyl cellulose, white sugar, magnesium aluminum silicate, di-sorbitol solution, and light anhydrous silicic acid; Calcium stearate, magnesium stearate, stearic acid, hydrogenated vegetable oil, talc, lycopod, kaolin, petrolatum, sodium stearate, cacao butter, sodium salicylate, magnesium salicylate, polyethylene glycol (PEG) 4000, PEG 6000, liquid paraffin, hydrogen Added soybean oil (Lubri wax), aluminum stearate, zinc stearate, sodium lauryl sulfate, magnesium oxide, macrogol, synthetic aluminum silicate, silicic anhydride, higher fatty acid, higher alcohol, silicone oil, paraffin oil, polyethylene glycol fatty acid ether, Lubricants such as starch, sodium chloride, sodium acetate, sodium oleate, dl-leucine, and light anhydrous silicic acid may be used.
본 발명에 따른 액제의 첨가제로는 물, 묽은 염산, 묽은 황산, 구연산나트륨, 모노스테아린산슈크로스류, 폴리옥시에칠렌소르비톨지방산에스텔류(트윈에스텔), 폴리옥시에칠렌모노알킬에텔류, 라놀린에텔류, 라놀린에스텔류, 초산, 염산, 암모니아수, 탄산암모늄, 수산화칼륨, 수산화나트륨, 프롤아민, 폴리비닐피롤리돈, 에칠셀룰로오스, 카르복시메칠셀룰로오스나트륨 등이 사용될 수 있다.Additives for the liquid formulation according to the present invention include water, dilute hydrochloric acid, dilute sulfuric acid, sodium citrate, sucrose monostearate, polyoxyethylene sorbitol fatty acid esters (tween esters), polyoxyethylene monoalkyl ethers, lanolin ethers, Lanolin esters, acetic acid, hydrochloric acid, aqueous ammonia, ammonium carbonate, potassium hydroxide, sodium hydroxide, prolamine, polyvinylpyrrolidone, ethyl cellulose, sodium carboxymethyl cellulose, and the like may be used.
본 발명에 따른 시럽제에는 백당의 용액, 다른 당류 혹은 감미제 등이 사용될 수 있으며, 필요에 따라 방향제, 착색제, 보존제, 안정제, 현탁화제, 유화제, 점조제 등이 사용될 수 있다.In the syrup according to the present invention, a solution of white sugar, other sugars, or a sweetener may be used, and aromatics, coloring agents, preservatives, stabilizers, suspending agents, emulsifiers, thickeners, etc. may be used as necessary.
본 발명에 따른 유제에는 정제수가 사용될 수 있으며, 필요에 따라 유화제, 보존제, 안정제, 방향제 등이 사용될 수 있다.Purified water may be used in the emulsion according to the present invention, and emulsifiers, preservatives, stabilizers, fragrances, etc. may be used as needed.
본 발명에 따른 현탁제에는 아카시아, 트라가칸타, 메칠셀룰로오스, 카르복시메칠셀룰로오스, 카르복시메칠셀룰로오스나트륨, 미결정셀룰로오스, 알긴산나트륨, 히드록시프로필메칠셀룰로오스(HPMC), HPMC 1828, HPMC 2906, HPMC 2910 등 현탁화제가 사용될 수 있으며, 필요에 따라 계면활성제, 보존제, 안정제, 착색제, 방향제가 사용될 수 있다.Suspension agents according to the present invention include acacia, tragacantha, methylcellulose, carboxymethylcellulose, sodium carboxymethylcellulose, microcrystalline cellulose, sodium alginate, hydroxypropylmethylcellulose (HPMC), HPMC 1828, HPMC 2906, HPMC 2910, etc. Agents may be used, and surfactants, preservatives, stabilizers, colorants, and fragrances may be used as needed.
본 발명에 따른 주사제에는 주사용 증류수, 0.9%염화나트륨주사액, 링겔주사액, 덱스트로스주사액, 덱스트로스+염화나트륨주사액, 피이지(PEG), 락테이티드 링겔주사액, 에탄올, 프로필렌글리콜, 비휘발성유-참기름, 면실유, 낙화생유, 콩기름, 옥수수기름, 올레인산에칠, 미리스트산 이소프로필, 안식향산벤젠과 같은 용제; 안식향산나트륨, 살리실산나트륨, 초산나트륨, 요소, 우레탄, 모노에칠아세트아마이드, 부타졸리딘, 프로필렌글리콜, 트윈류, 니정틴산아미드, 헥사민, 디메칠아세트아마이드와 같은 용해보조제; 약산 및 그 염(초산과 초산나트륨), 약염기 및 그 염(암모니아 및 초산암모니움), 유기화합물, 단백질, 알부민, 펩톤, 검류와 같은 완충제; 염화나트륨과 같은 등장화제; 중아황산나트륨(NaHSO3) 이산화탄소가스, 메타중아황산나트륨(Na2S2O5), 아황산나트륨(Na2SO3), 질소가스(N2), 에칠렌디아민테트라초산과 같은 안정제; 소디움비설파이드 0.1%, 소디움포름알데히드 설폭실레이트, 치오우레아, 에칠렌디아민테트라초산디나트륨, 아세톤소디움비설파이트와 같은 황산화제; 벤질알코올, 클로로부탄올, 염산프로카인, 포도당, 글루콘산칼슘과 같은 무통화제; 시엠시나트륨, 알긴산나트륨, 트윈 80, 모노스테아린산알루미늄과 같은 현탁화제를 포함할 수 있다.Injections according to the present invention include distilled water for injection, 0.9% sodium chloride injection, IV injection, dextrose injection, dextrose + sodium chloride injection, PEG, lactated IV injection, ethanol, propylene glycol, non-volatile oil-sesame oil , solvents such as cottonseed oil, peanut oil, soybean oil, corn oil, ethyl oleate, isopropyl myristate, and benzene benzoate; solubilizing agents such as sodium benzoate, sodium salicylate, sodium acetate, urea, urethane, monoethylacetamide, butazolidine, propylene glycol, twins, nijuntinamide, hexamine, and dimethylacetamide; buffers such as weak acids and their salts (acetic acid and sodium acetate), weak bases and their salts (ammonia and ammonium acetate), organic compounds, proteins, albumin, peptone, and gums; tonicity agents such as sodium chloride; Stabilizers such as sodium bisulfite (NaHSO 3 ) carbon dioxide gas, sodium metabisulfite (Na 2 S 2 O 5 ), sodium sulfite (Na 2 SO 3 ), nitrogen gas (N 2 ), ethylenediaminetetraacetic acid; Sulfating agents such as sodium bisulfide 0.1%, sodium formaldehyde sulfoxylate, thiourea, ethylenediamine disodium tetraacetate, acetone sodium bisulfite; analgesics such as benzyl alcohol, chlorobutanol, procaine hydrochloride, glucose, and calcium gluconate; Suspending agents such as Siemesis sodium, sodium alginate,
본 발명에 따른 좌제에는 카카오지, 라놀린, 위텝솔, 폴리에틸렌글리콜, 글리세로젤라틴, 메칠셀룰로오스, 카르복시메칠셀룰로오스, 스테아린산과 올레인산의 혼합물, 수바날(Subanal), 면실유, 낙화생유, 야자유, 카카오버터+콜레스테롤, 레시틴, 라네트왁스, 모노스테아린산글리세롤, 트윈 또는 스판, 임하우젠(Imhausen), 모놀렌(모노스테아린산프로필렌글리콜), 글리세린, 아뎁스솔리두스(Adeps solidus), 부티룸 태고-G(Buytyrum Tego-G), 세베스파마 16(Cebes Pharma 16), 헥사라이드베이스 95, 코토마(Cotomar), 히드록코테 SP, S-70-XXA, S-70-XX75(S-70-XX95), 히드록코테(Hydrokote) 25, 히드록코테 711, 이드로포스탈(Idropostal), 마사에스트라리움(Massa estrarium, A, AS, B, C, D, E, I, T), 마사-MF, 마수폴, 마수폴-15, 네오수포스탈-엔, 파라마운드-B, 수포시로(OSI, OSIX, A, B, C, D, H, L), 좌제기제 IV 타입(AB, B, A, BC, BBG, E, BGF, C, D, 299), 수포스탈(N, Es), 웨코비(W, R, S, M ,Fs), 테제스터 트리글리세라이드 기제(TG-95, MA, 57)와 같은 기제가 사용될 수 있다.The suppository according to the present invention includes cacao butter, lanolin, witapsol, polyethylene glycol, glycerogelatin, methylcellulose, carboxymethylcellulose, a mixture of stearic acid and oleic acid, subanal, cottonseed oil, peanut oil, palm oil, cacao butter + Cholesterol, Lecithin, Lannet Wax, Glycerol Monostearate, Tween or Span, Imhausen, Monolen (Propylene Glycol Monostearate), Glycerin, Adeps Solidus, Buytyrum Tego-G -G), Cebes Pharma 16, Hexalide Base 95, Cotomar, Hydroxycote SP, S-70-XXA, S-70-XX75 (S-70-XX95),
경구 투여를 위한 고형제제에는 정제, 환제, 산제, 과립제, 캡슐제 등이 포함되며, 이러한 고형제제는 상기 추출물에 적어도 하나 이상의 부형제 예를 들면, 전분, 칼슘카보네이트(calcium carbonate), 수크로스(sucrose) 또는 락토오스(lactose), 젤라틴 등을 섞어 조제된다. 또한 단순한 부형제 이외에 마그네슘 스티레이트 탈크 같은 윤활제들도 사용된다. Solid preparations for oral administration include tablets, pills, powders, granules, capsules, etc., and these solid preparations contain at least one excipient, for example, starch, calcium carbonate, sucrose, etc. ) or by mixing lactose and gelatin. In addition to simple excipients, lubricants such as magnesium stearate and talc are also used.
경구 투여를 위한 액상제제로는 현탁제, 내용액제, 유제, 시럽제 등이 해당되는데 흔히 사용되는 단순희석제인 물, 리퀴드 파라핀 이외에 여러 가지 부형제, 예를 들면 습윤제, 감미제, 방향제, 보존제 등이 포함될 수 있다. 비경구 투여를 위한 제제에는 멸균된 수용액, 비수성용제, 현탁제, 유제, 동결건조제제, 좌제가 포함된다. 비수성용제, 현탁제로는 프로필렌글리콜(propylene glycol), 폴리에틸렌 글리콜, 올리브 오일과 같은 식물성 기름, 에틸올레이트와 같은 주사 가능한 에스테르 등이 사용될 수 있다. Liquid preparations for oral administration include suspensions, solutions for oral administration, emulsions, syrups, etc. In addition to water and liquid paraffin, which are commonly used simple diluents, various excipients such as wetting agents, sweeteners, aromatics, and preservatives may be included. there is. Formulations for parenteral administration include sterilized aqueous solutions, non-aqueous solvents, suspensions, emulsions, freeze-dried formulations, and suppositories. Propylene glycol, polyethylene glycol, vegetable oils such as olive oil, and injectable esters such as ethyl oleate may be used as non-aqueous solvents and suspending agents.
본 발명에 따른 약학적 조성물은 약학적으로 유효한 양으로 투여한다. 본 발명에 있어서, "약학적으로 유효한 양"은 의학적 치료에 적용 가능한 합리적인 수혜/위험 비율로 질환을 치료하기에 충분한 양을 의미하며, 유효용량 수준은 환자 질환의 종류, 중증도, 약물의 활성, 약물에 대한 민감도, 투여 시간, 투여 경로 및 배출비율, 치료기간, 동시 사용되는 약물을 포함한 요소 및 기타 의학 분야에 잘 알려진 요소에 따라 결정될 수 있다. The pharmaceutical composition according to the present invention is administered in a pharmaceutically effective amount. In the present invention, "pharmaceutically effective amount" means an amount sufficient to treat a disease with a reasonable benefit / risk ratio applicable to medical treatment, and the effective dose level is the type of patient's disease, severity, activity of the drug, It may be determined according to factors including sensitivity to the drug, administration time, route of administration and excretion rate, duration of treatment, drugs used concurrently, and other factors well known in the medical field.
본 발명에 따른 약학적 조성물은 개별 치료제로 투여하거나 다른 치료제와 병용하여 투여될 수 있고 종래의 치료제와는 순차적 또는 동시에 투여될 수 있으며, 단일 또는 다중 투여될 수 있다. 상기한 요소들을 모두 고려하여 부작용 없이 최소한의 양으로 최대 효과를 얻을 수 있는 양을 투여하는 것이 중요하며, 이는 본 발명이 속하는 기술분야에 통상의 기술자에 의해 용이하게 결정될 수 있다.The pharmaceutical composition according to the present invention may be administered as an individual therapeutic agent or in combination with other therapeutic agents, may be administered sequentially or simultaneously with conventional therapeutic agents, and may be administered single or multiple times. Considering all of the above factors, it is important to administer an amount that can obtain the maximum effect with the minimum amount without side effects, which can be easily determined by a person skilled in the art to which the present invention belongs.
본 발명의 약학적 조성물은 개체에게 다양한 경로로 투여될 수 있다. 투여의 모든 방식은 예상될 수 있는데, 예를 들면, 경구 복용, 피하 주사, 복강 투여, 정맥 주사, 근육 주사, 척수 주위 공간(경막내) 주사, 설하 투여, 볼점막 투여, 직장 내 삽입, 질 내 삽입, 안구 투여, 귀 투여, 비강 투여, 흡입, 입 또는 코를 통한 분무, 피부 투여, 경피 투여 등에 따라 투여될 수 있다.The pharmaceutical composition of the present invention can be administered to a subject by various routes. All modes of administration can be envisaged, eg oral administration, subcutaneous injection, intraperitoneal administration, intravenous injection, intramuscular injection, paraspinal space (intrathecal) injection, sublingual administration, buccal administration, intrarectal insertion, vaginal It can be administered by intraoral insertion, ocular administration, otic administration, nasal administration, inhalation, spraying through the mouth or nose, dermal administration, transdermal administration, and the like.
본 발명의 약학적 조성물은 치료할 질환, 투여 경로, 환자의 연령, 성별, 체중 및 질환의 중등도 등의 여러 관련 인자와 함께 활성성분인 약물의 종류에 따라 결정된다.The pharmaceutical composition of the present invention is determined according to the type of drug as an active ingredient together with various related factors such as the disease to be treated, the route of administration, the age, sex, weight and severity of the disease of the patient.
본 발명의 또 다른 양태로서, 본 발명은 소인제 추출물을 유효성분으로 포함하는 조성물을 개체에 투여하는 단계를 포함하는, 항산화, 항염증, 모공축소, 주름예방 또는 개선 방법을 제공한다.As another aspect of the present invention, the present invention provides a method for antioxidation, anti-inflammatory, pore reduction, wrinkle prevention or improvement comprising the step of administering to a subject a composition containing a soinje extract as an active ingredient.
본 발명의 또 다른 양태로서, 본 발명은 소인제 추출물을 유효성분으로 포함하는 조성물을 개체에 투여하는 단계를 포함하는 항산화, 항염증, 모공축소, 주름예방 또는 개선을 위한 미용 방법을 제공한다.As another aspect of the present invention, the present invention provides a cosmetic method for antioxidation, anti-inflammatory, pore reduction, wrinkle prevention or improvement comprising the step of administering to a subject a composition containing a soinje extract as an active ingredient.
본 발명의 또 다른 양태로서, 본 발명은 소인제 추출물을 유효성분으로 포함하는 조성물의 항산화, 항염증, 모공축소, 주름예방 또는 개선 용도를 제공한다.As another aspect of the present invention, the present invention provides antioxidant, anti-inflammatory, pore reduction, anti-wrinkle or improvement uses of a composition containing a soinje extract as an active ingredient.
본 발명의 또 다른 양태로서, 본 발명은 소인제 추출물을 유효성분으로 포함하는 조성물의 항산화, 항염증, 모공축소, 주름예방 또는 개선에 이용되는 화장품을 생산하기 위한 용도를 제공한다.As another aspect of the present invention, the present invention provides the use of a composition containing a soinje extract as an active ingredient for producing cosmetics used for antioxidation, anti-inflammatory, pore reduction, wrinkle prevention or improvement.
본 발명의 또 다른 양태로서, 본 발명은 항산화, 또는 항염증에 이용되는 약제를 생산하기 위한 소인제 추출물의 용도를 제공한다.As another aspect of the present invention, the present invention provides the use of a soinje extract for producing a drug used for antioxidant or anti-inflammatory.
본 발명에 있어서, “예방”이란 목적하는 질환의 발병을 억제하거나 지연시키는 모든 행위를 의미하고, “치료”란 본 발명에 따른 약학적 조성물의 투여에 의해 목적하는 질환과 그에 따른 대사 이상 증세가 호전되거나 이롭게 변경되는 모든 행위를 의미하며,“개선”이란 본 발명에 따른 조성물의 투여에 의해 목적하는 질환과 관련된 파라미터, 예를 들면 증상의 정도를 감소시키는 모든 행위를 의미한다.In the present invention, "prevention" means any action that suppresses or delays the onset of a desired disease, and "treatment" means that a desired disease and its metabolic abnormalities are prevented by administration of the pharmaceutical composition according to the present invention. It means any action that is improved or changed beneficially, and "improvement" means any action that reduces the parameter related to the target disease, for example, the severity of symptoms, by administration of the composition according to the present invention.
본 발명에 있어서,“개체”란 질병의 치료를 필요로 하는 대상을 의미하고, 보다 구체적으로는 인간 또는 비-인간인 영장류, 생쥐 (mouse), 쥐 (rat), 개, 고양이, 말, 및 소 등의 포유류를 의미한다.In the present invention, “individual” means a subject in need of treatment of a disease, and more specifically, a human or non-human primate, mouse, rat, dog, cat, horse, and It means mammals such as cattle.
본 발명에 있어서,“투여”란 임의의 적절한 방법으로 개체에게 소정의 본 발명의 조성물을 제공하는 것을 의미한다.In the context of the present invention, "administration" means providing a given composition of the present invention to a subject by any suitable method.
이하, 본 발명의 이해를 돕기 위하여 바람직한 실시예 및 실험예를 제시한다. 그러나 하기의 실시예 및 실험예는 본 발명을 보다 쉽게 이해하기 위하여 제공되는 것일 뿐, 하기 실시예에 의해 본 발명의 내용이 한정되는 것은 아니다.Hereinafter, preferred embodiments and experimental examples are presented to aid understanding of the present invention. However, the following examples and experimental examples are only provided to more easily understand the present invention, and the contents of the present invention are not limited by the following examples.
[실시예] [Example]
실시예 1. 소인제 시료 준비Example 1. Sweeping agent sample preparation
소인제(A. sedifolium)는 심폴(simpol, www.simpol.co.kr)에서 2021년 3월에 구매하여 줄기를 제거한 후, 잎을 45℃ dry oven (FO600M, Jeiotech, Daejeon, Korea)에서 건조시킨 후, 40 mesh로 분쇄하여 시료로 사용하였다.A. sedifolium was purchased from Simpol (www.simpol.co.kr) in March 2021, the stems were removed, and the leaves were dried in a dry oven (FO600M, Jeiotech, Daejeon, Korea) at 45℃. After that, it was pulverized with 40 mesh and used as a sample.
실시예 2. 소인제 추출물 제조Example 2. Soinje Extract Preparation
소인제 잎 분말 1 g에 증류수 200 mL를 가하고 용액이 100 mL가 될 때까지 가열하고 증발시킨 후, 냉각하여 24시간 동안 상온에서 교반 추출하여 열수 추출물을 제조하였다. 또한, 에탄올 추출물은 소인제 잎 분말 1 g에 50% 에탄올 100 mL를 첨가하여 24시간 동안 상온에서 교반 추출하였다. 각 추출물은 Whatman No. 1 여과지(Whatman inc., piscataway, New jersey, USA)로 여과한 후 필요에 따라 회전식 진공 증발기(rotary vacuum evaporator, Eyela NE, Tokyo, Japan)에서 농축하여 추출물 시료로 사용하였다.200 mL of distilled water was added to 1 g of the leaf powder, heated until the solution became 100 mL, evaporated, cooled, and extracted with stirring at room temperature for 24 hours to prepare a hot water extract. In addition, the ethanol extract was extracted with stirring at room temperature for 24 hours by adding 100 mL of 50% ethanol to 1 g of soinje leaf powder. Each extract was prepared using Whatman No. After filtering with 1 filter paper (Whatman inc., piscataway, New Jersey, USA), the extract was used as an extract sample after being concentrated in a rotary vacuum evaporator (Eyela NE, Tokyo, Japan) if necessary.
실시예 3. 총 페놀 함량(TPC ; Total phenolic compounds) 정량Example 3. Quantification of total phenolic compounds (TPC)
TPC 측정은 Folin-Denis의 방법(Journal of Biological Chemistry, 12(2), 239-243.)에 따라 측정하였다. 소인제 추출물 1 mL에 95% 에탄올 1 mL 및 증류수 5 mL를 첨가하고, 1 N Folin-ciocalteu 시약 0.5 mL를 넣은 후, 볼텍싱(voltexing)을 하고 5분간 방치하고 5% Na2CO3 1 mL를 가하였다. 그런 다음, 1시간 동안 암실에 방치하고 725 nm의 파장에서 흡광도를 UV-vis photospectrometer (Optizen 3220 UV, Merasys Co. Ltd., Seoul, Korea)를 이용하여 측정하였다. 총 페놀 함량은 갈산(gallic acid)을 이용한 표준 곡선으로부터 양을 환산하여 정량하였다. TPC was measured according to the method of Folin-Denis (Journal of Biological Chemistry, 12(2), 239-243.). Add 1 mL of 95% ethanol and 5 mL of distilled water to 1 mL of Soinje extract, add 0.5 mL of 1 N Folin-ciocalteu reagent, vortexing, leave for 5 minutes, and 1 mL of 5% Na 2 CO 3 was added. Then, it was left in the dark for 1 hour and the absorbance at a wavelength of 725 nm was measured using a UV-vis photospectrometer (Optizen 3220 UV, Merasys Co. Ltd., Seoul, Korea). The total phenol content was quantified by converting the amount from a standard curve using gallic acid.
실시예 4. DPPH(2,2-diphenyl-1-picrylhydrazyl) 라디칼 소거 활성 측정Example 4. Measurement of DPPH (2,2-diphenyl-1-picrylhydrazyl) radical scavenging activity
DPPH 라디칼 소거 활성은 Blios의 방법(Bios MS (1958), Nature 181: 11 99-1200)에 따라 측정하였다. 반응구는 각 소인제 추출물 시료 1 mL에 100 μM DPPH 3 mL를 넣고, 대조구에는 시료 대신 증류수 1 mL를 첨가하여 볼텍싱(vortexing)한 후 실온에서 15분 동안 반응시켜 517 nm 에서 흡광도를 측정하였다. 양성 대조구는 디부틸히드록시톨루엔(BHT; butylated hydroxytoluene, Sigma Aldrich Co., St Louis, MO, USA)을 사용하였다. 한편, DPPH 라디칼 소거 활성(%)은 하기 식 1에 의해 계산하였다. DPPH radical scavenging activity was measured according to the method of Blios (Bios MS (1958), Nature 181: 11 99-1200). In the reaction group, 3 mL of 100 μM DPPH was added to 1 mL of each Soinje extract sample, and 1 mL of distilled water was added to the control group instead of the sample, followed by vortexing, followed by reaction at room temperature for 15 minutes to measure absorbance at 517 nm. As a positive control, dibutylated hydroxytoluene (BHT; Sigma Aldrich Co., St Louis, MO, USA) was used. On the other hand, DPPH radical scavenging activity (%) was calculated by
[식 1][Equation 1]
DPPH 라디칼 소거 활성(%) = (1-반응구의 흡광도/대조구의 흡광도)×100.DPPH radical scavenging activity (%) = (1-absorbance of reactive group / absorbance of control group) × 100.
실시예 5. ABTS(2,2'-azino-bis (3-ethylbenzothiazoline 6-sulphonic acid) 라디칼 저해 활성 측정 Example 5. Measurement of ABTS (2,2'-azino-bis (3-ethylbenzothiazoline 6-sulphonic acid) radical inhibitory activity
ABTS 라디칼 저해 활성은 Fellegrini 등의 방법(Fellegrini N, Ke R, Yang M, Rice-Evans C (1999). Meth in Enz, 299: 379-389)에 따라 측정하였다. 구체적으로, 7 mM ABTS 50 mL와 140 mM K2S2O8 0.88 mL을 섞어 암실에서 약 15시간 이상 반응시켜 라디칼을 형성시킨 후, 이를 50% 에탄올과 약 1:88 비율로 섞어 734 nm에서 흡광도 값이 약 0.7±0.02이 되도록 조절한 ABTS 용액을 사용하였다. 반응구는 소인제 추출물 시료 200 μL와 ABTS 용액 4 mL를 혼합하였으며, 대조구에는 시료 대신 증류수 200 μL를 첨가하여 볼텍싱한 후 2분간 반응시키고 734 nm에서 흡광도를 측정하였다. 양성 대조구로 BHT를 사용하였으며, ABTS 라디칼 소거 활성(%)은 하기 식2에 의해 계산하였다.ABTS radical inhibitory activity was measured according to the method of Fellegrini et al. (Fellegrini N, Ke R, Yang M, Rice-Evans C (1999). Meth in Enz, 299: 379-389). Specifically, after mixing 50 mL of 7 mM ABTS and 0.88 mL of 140 mM K 2 S 2 O 8 and reacting in a dark room for about 15 hours or more to form radicals, they were mixed with 50% ethanol in a ratio of about 1:88 and at 734 nm An ABTS solution adjusted to have an absorbance value of about 0.7±0.02 was used. In the reaction zone, 200 μL of the soybean extract sample and 4 mL of the ABTS solution were mixed, and in the control group, 200 μL of distilled water was added instead of the sample, vortexed, reacted for 2 minutes, and absorbance was measured at 734 nm. BHT was used as a positive control, and ABTS radical scavenging activity (%) was calculated by the following equation 2.
[식 2] [Equation 2]
ABTS 라디칼 소거 활성(%) = (1- 반응구의 흡광도/대조구의 흡광도) × 100.ABTS radical scavenging activity (%) = (1-absorbance of reactive group/absorbance of control group) × 100.
실시예 6. PF(Antioxidant protection factor) 측정Example 6. PF (Antioxidant protection factor) measurement
항산화 보호 인자(PF; antioxidant protection factor)는 Andarwulan과 Shetty의 방법(Andarwulan N, Shetty K (1999). J Agric Food Chem, 47: 1776-1780)에 따라 측정되었다. 구체적으로, 클로로포름(chloroform) 50 mL에 베타카로틴(β-carotene) 50 mg을 녹인 용액 1 mL를 빛을 차단하고 농축시킨 후, 리놀레산(linoleic acid) 20 μL, Tween 40 184 μL, H2O2 50 mL를 첨가하여 에멀젼을 제조하였다. 이후 소인제 추출물 시료 100 μL에 에멀젼 5 mL를 넣고 볼텍싱하고 50℃ 수조에서 30분간 빛을 차단하여 반응시킨 다음, 얼음 물에서 5분간 냉각시키고, 470nm에서 흡광도를 측정하였다. 양성 대조구로 BHT를 사용하였으며, PF값은 하기 식 3에 의해 계산하였다.Antioxidant protection factor (PF) was measured according to the method of Andarwulan and Shetty (Andarwulan N, Shetty K (1999). J Agric Food Chem, 47: 1776-1780). Specifically, 1 mL of a solution of 50 mg of beta-carotene in 50 mL of chloroform was concentrated after blocking light, 20 μL of linoleic acid, 184 μL of
[식 3][Equation 3]
PF = 반응구의 흡광도/대조구의 흡광도.PF = absorbance of reaction/absorbance of control.
실시예 7. TBARs(Thiobarbituric acid reactive substances) 저해 활성 측정Example 7. Measurement of Thiobarbituric acid reactive substances (TBARs) inhibitory activity
TBARs 저해 활성은 Buege와 Aust의 방법(Buege JA, Aust SD (1978). Methods Enzymol 52: 302-310)에 따라 측정되었다. 구체적으로, 5% 리놀레산과 1% tween 40을 등량 넣어 핸드 믹서로 잘 섞어서 에멀젼을 제조하고, 소인제 추출물 시료 0.2 mL에 에멀젼 0.8 mL를 넣고 50℃ 수조에서 16시간 이상 반응시켰다. 그런 다음, TCA (trichloroacetic acid), TBA(thiobarbituric acid), 및 HCl을 혼합하여 제조한 TBA 스톡 용액 100 mL와 2% BHT 3 mL를 섞어서 제조한 TBA 시약 4 mL를 첨가하고, 잘 혼합하였다. 그 후, 끓는 물에 중탕으로 15분간 가열한 후 얼음 물에서 10분간 냉각시켰다. 그런 다음, 원심분리기(VISION SCIENTIFIC, Daejeon, Korea)에서 2000 rpm으로 20분간 원심분리한 후, 10분간 방치하고 532 nm에서 흡광도를 측정하였다. 양성 대조구로로 BHT를 사용하였으며, TBARs 저해 활성(%)은 하기 식 4에 의해 계산하였다.TBARs inhibitory activity was measured according to the method of Buege and Aust (Buege JA, Aust SD (1978). Methods Enzymol 52: 302-310). Specifically, 5% linoleic acid and 1
[식 4][Equation 4]
TBARs 저해 활성(%) = (1-반응구의 흡광도/대조구의 흡광도)×100.TBARs inhibitory activity (%) = (1-absorbance of reactive group / absorbance of control group) × 100.
실시예 8. 엘라스타제 저해 효과 측정Example 8. Measurement of elastase inhibitory effect
엘라스타제(Elastase) 저해 효과는 Kraunsoe 등의 방법(Kraunsoe JA, Claridge TD, Lowe G (1996). Biochemistry 35: 9090-9096)에 따라 측정하였다. 소인제 추출물 시료 0.1 mL에 0.2 M Tris-HCl 완충액(pH 8.0)으로 녹인 0.8 mM 기질액 N-succinyl-(Ala)3-p-nitroanilide(Sigma Aldrich Co.) 0.1 mL를 넣고, 완충액(pH 8.0) 1 mL를 추가하였다. 그런 다음, 완충액에 녹인 1.0 U/mL 돼지 췌장 엘라스타제(Porcine pancreatic elastase, Sigma Aldrich Co.) 0.1 mL를 추가하여 볼텍싱한 후, 수조에서 37℃로 20분간 반응시키고 얼음물에서 5분간 식힌 다음, 410 nm의 파장에서 흡광도를 측정하였다. 양성 대조구로 우르솔산(ursolic acid)을 사용하였으며, 엘라스타제 저해 활성 (%)은 하기 식 5에 의해 계산하였다.Elastase inhibitory effect was measured according to the method of Kraunsoe et al. (Kraunsoe JA, Claridge TD, Lowe G (1996). Biochemistry 35: 9090-9096). 0.1 mL of 0.8 mM substrate solution N-succinyl-(Ala)3-p-nitroanilide (Sigma Aldrich Co.) dissolved in 0.2 M Tris-HCl buffer (pH 8.0) was added to 0.1 mL of Soinje extract sample, and the buffer (pH 8.0) was added. ) 1 mL was added. Then, 0.1 mL of 1.0 U/mL porcine pancreatic elastase (Sigma Aldrich Co.) dissolved in buffer was added and vortexed, followed by reaction in a water bath at 37°C for 20 minutes and cooling in ice water for 5 minutes. , absorbance was measured at a wavelength of 410 nm. Ursolic acid was used as a positive control, and the elastase inhibitory activity (%) was calculated by the following formula 5.
[식 5][Equation 5]
엘라스타제 저해 활성 (%) = (1-반응구의 흡광도/대조구의 흡광도)×100.Elastase inhibitory activity (%) = (1-absorbance of reactive group / absorbance of control group) × 100.
실시예 9. 콜라게나제 저해 효과 측정Example 9. Collagenase inhibitory effect measurement
콜라게나제(Collagenase) 저해 효과는 Wunsch과 Heindrich 의 방법(Wunsch E, Heidrich HG (1963). Hoppe-Seyler's Z Physiol Chem 333: 149-151)에 따라 측정하였다. 소인제 추출물 시료 0.1 mL에 0.1 M tris-HCl과 4 mM CaCl₂가 혼합된 완충액(pH 7.5)을 이용하여 녹인 기질액 0.4 mM 4-phenylazobenzyloxycarbonyl-pro-Leu-Gly-Pro-D-Arg (Sigma Aldrich Co.) 0.25 mL를 넣었다. 그런 다음, 완충액(pH 7.5) 0.15 mL를 추가하였다. 그 후에, 완충액(pH 7.5)을 이용하여 제조한 100 U/mL 콜라게나제 from clostridium histolyticum(Sigma Aldrich Co.)을 0.15 mL 추가하였다. 그런 다음, 수조에서 25℃로 20분간 반응시킨 후, 종료 시약인 6% 시트르산(citric acid) 0.5mL를 넣고, 에틸 아세테이트(ethyl acetate)를 2 mL를 추가하여 볼텍싱하고, 320 nm의 파장에서 흡광도를 측정하였다. 양성 대조구로 EGCG ((-)-epigallocatechin-3-o-gallate)를 사용하였으며, 콜라게나제 저해 활성(%)은 하기 식 6에 의해 계산하였다.Collagenase inhibitory effect was measured according to the method of Wunsch and Heindrich (Wunsch E, Heidrich HG (1963). Hoppe-Seyler's Z Physiol Chem 333: 149-151). 0.4 mM 4-phenylazobenzyloxycarbonyl-pro-Leu-Gly-Pro-D-Arg (Sigma Aldrich Co.) 0.25 mL was added. Then, 0.15 mL of buffer (pH 7.5) was added. After that, 0.15 mL of 100 U/mL collagenase from clostridium histolyticum (Sigma Aldrich Co.) prepared using a buffer (pH 7.5) was added. Then, after reacting in a water bath at 25 ° C. for 20 minutes, 0.5 mL of 6% citric acid as a termination reagent was added, 2 mL of ethyl acetate was added and vortexed, and at a wavelength of 320 nm Absorbance was measured. EGCG ((-)-epigallocatechin-3-o-gallate) was used as a positive control, and collagenase inhibitory activity (%) was calculated by the following formula 6.
[식 6] [Equation 6]
콜라게나제 저해 활성(%) = (1-반응구의 흡광도/대조구의 흡광도)×100.Collagenase inhibitory activity (%) = (1-absorbance of reaction group / absorbance of control group) × 100.
실시예 10. 수렴 효과 활성 측정Example 10. Convergence effect activity measurement
수렴 효과는 Lee JT, Jeong YS, 및 An BJ 의 방법(The Korea Journal of Herbology, 17(2), 51-51)에 따라 측정하였다. 구체적으로, 피부 단백질과 유사한 혈액 단백질인 헤모글로빈(hemoglobin)을 기질로 사용하였다. e-Tube에 소인제 추출물 시료 0.7 mL에 0.2 M 인산 나트륨 완충액(sodium phosphate buffer, pH 7.5)에 녹인 0.5% 헤모글로빈 용액(Sigma Aldrich Co.)을 0.35 mL를 넣은 후, 완충액(pH 7.5) 0.35 mL를 추가하였다. 그 후, 볼텍싱한 다음 원심분리기(CF-10, Daihan Sci. Co. Ltd. Wonju, Korea)를 이용하여 13,500 rpm으로 5분 동안 원심 분리하여, 응고된 혈액 단백질을 가라앉히고 576 nm에서 흡광도를 측정하였다. 양성 대조구로 타닌산(tannic acid)을 사용하였으며, 수렴 효과(%)는 하기 식 7에 의해 계산하였다.The astringent effect was measured according to the method of Lee JT, Jeong YS, and An BJ (The Korea Journal of Herbology, 17(2), 51-51). Specifically, hemoglobin, a blood protein similar to skin protein, was used as a substrate. After adding 0.35 mL of 0.5% hemoglobin solution (Sigma Aldrich Co.) dissolved in 0.2 M sodium phosphate buffer (pH 7.5) to 0.7 mL of soyin extract sample in the e-Tube, 0.35 mL of the buffer (pH 7.5) was added. After vortexing, centrifugation was performed at 13,500 rpm for 5 minutes using a centrifuge (CF-10, Daihan Sci. Co. Ltd. Wonju, Korea) to settle coagulated blood proteins and absorbance at 576 nm. measured. Tannic acid was used as a positive control, and the astringent effect (%) was calculated by Equation 7 below.
[식 7][Equation 7]
수렴 효과(%) = (1-반응구의 흡광도/대조구의 흡광도)×100.Convergence effect (%) = (1-absorbance of reaction group/absorbance of control group)×100.
실시예 11. 히알루로니다제 저해 효과 측정Example 11. Measurement of hyaluronidase inhibitory effect
히알루로니다제(Hyaluronidase, HAase) 저해 효과는 Dorfman와 Ott의 방법(Dorfman A, Ott ML (1948), J Biol Chem 172: 367-375)에 따라 측정하였다. 구체적으로, 소인제 추출물 시료 0.5 mL에 20 mM 인산 나트륨 완충액(sodium phosphate phosphate buffer, pH 6.9)으로 녹인 HAase(200 U/mL) 0.5 mL를 첨가한 뒤, 수조에서 38℃로 5분간 반응시켰다. 그런 다음, 0.3 M 인산 완충액(phosphate buffer, pH 5.3)로 녹인 기질 0.4% 히알루론산(Hyaluronic acid) 0.5 mL을 넣고 다시 수조에서 38℃로 45분 동안 반응시켰다. 이후 종료시약으로 0.04 M 아세테이트 완충액(acetate buffer, pH 3.7)으로 녹인 알부민 용액 5 mL를 첨가하여 반응을 종료시키고, 5분간 방치한 후 600 nm에서 투과율(%)을 측정하였다. 양성 대조구로 더 강력한 저해 활성을 가지고 핵 인자(nuclear factor)-κB(NF-κB) 억제제로 알려진 피롤리딘 디티오카바메이트(PDTC; pyrrollidine dithiocarbamate)를 사용하였으며, 히알루로니다제 저해 활성(%)은 하기 식 8에 의해 계산하였다.Hyaluronidase (HAase) inhibitory effect was measured according to the method of Dorfman and Ott (Dorfman A, Ott ML (1948), J Biol Chem 172: 367-375). Specifically, 0.5 mL of HAase (200 U/mL) dissolved in 20 mM sodium phosphate buffer (pH 6.9) was added to 0.5 mL of the Soinje extract sample, followed by reaction in a water bath at 38 ° C. for 5 minutes. Then, 0.5 mL of substrate 0.4% hyaluronic acid dissolved in 0.3 M phosphate buffer (pH 5.3) was added and reacted again in a water bath at 38° C. for 45 minutes. Thereafter, as a termination reagent, 5 mL of an albumin solution dissolved in 0.04 M acetate buffer (acetate buffer, pH 3.7) was added to terminate the reaction, and the reaction was allowed to stand for 5 minutes, and transmittance (%) was measured at 600 nm. As a positive control, pyrrollidine dithiocarbamate (PDTC), which has a stronger inhibitory activity and is known as a nuclear factor-κB (NF-κB) inhibitor, was used, and hyaluronidase inhibitory activity (% ) was calculated by Equation 8 below.
[식 8][Equation 8]
히알루로니다제 저해 활성(%) = (1-반응구의 투과율/대조구의 투과율)×100. Hyaluronidase inhibitory activity (%) = (1-permeability of reaction group / transmittance of control group) × 100.
실시예 12. 통계 분석Example 12. Statistical analysis
본 발명의 실험 결과는 평균과 표준오차로 나타내었다. 또한, SPSS software 25 (SPSS Inc., Chicago, IL, USA)을 이용하여 실험군 간의 유의차를 검증하고자 일원 배치 분산분석(One-way ANOVA)을 실시하였으며, Duncan의 다중 범위 테스트(Duncan's multiple range test)로 사후검정을 실시하여 p<0.05 수준에서 상호 비교하였다.The experimental results of the present invention are expressed as mean and standard error. In addition, using SPSS software 25 (SPSS Inc., Chicago, IL, USA), one-way ANOVA was conducted to verify the significant difference between the experimental groups, and Duncan's multiple range test ), a post hoc test was performed and mutual comparisons were made at the p<0.05 level.
[실험예][Experimental example]
실험예 1. 소인제 추출물의 페놀(TPC) 함량 확인Experimental Example 1. Confirmation of phenol (TPC) content of soinje extract
소인제 잎 추출물에서 항산화 활성을 확인할 수 있는 총 페놀 함량(TPC; total phenolic compounds)을 정량하기 위하여, 열수과 농도별 에탄올(10 내지 100% 에탄올) 추출물 각각의 TPC를 비교하였다. 그 결과는 도 1에 나타내었다.In order to quantify the total phenolic compounds (TPC), which can confirm the antioxidant activity in the Soinje leaf extract, the TPC of each of the hot water and ethanol (10 to 100% ethanol) extracts for each concentration was compared. The results are shown in Figure 1.
도 1에 나타난 바와 같이, 50% 에탄올 추출물에서 1 g당 페놀 함량이 61.64 mg으로 가장 높은 TPC를 나타냈으며, 열수 추출물은 1 g당 34.49 mg로 두 번째로 높은 TPC를 나타내었다.As shown in FIG. 1, the phenol content per 1 g in the 50% ethanol extract showed the highest TPC of 61.64 mg, and the hot water extract showed the second highest TPC of 34.49 mg per 1 g.
실험예 2. 소인제 추출물의 항산화 효과 확인Experimental Example 2. Confirmation of antioxidant effect of soinje extract
소인제 추출물을 사용한 항산화 실험을 위해 추출물을 25, 50, 75 및 100 μg/mL의 4가지 페놀 농도로 테스트하였다. For antioxidant experiments using Soinje extract, the extract was tested at four phenol concentrations of 25, 50, 75, and 100 μg/mL.
2-1. DPPH 라디칼 소거 활성 확인2-1. Confirmation of DPPH radical scavenging activity
DPPH 라디칼은 항산화 물질의 전자공여능으로 인해 방향족 아민류에 의해 환원되어 짙은 자색에서 탈색되는 정도에 따라 항산화 효과를 나타내는 척도로 활용된다. 이에 소인제 잎 추출물의 DPPH 라디칼 소거 활성을 확인하였다. 그 결과는 도 2a에 나타내었다.The DPPH radical is used as a measure of the antioxidant effect according to the degree of discoloration from dark purple by reduction by aromatic amines due to the electron donating ability of antioxidants. Accordingly, the DPPH radical scavenging activity of the Soinje leaf extract was confirmed. The results are shown in Figure 2a.
도 2a에 나타난 바와 같이, 열수 추출물의 경우, 25, 50, 75, 100 μg/mL TPC 농도에서 각각 86.35, 87.54, 89.10, 89.24%의 소거 활성을 나타내었고, 50% 에탄올 추출물의 경우, 25, 50, 75, 100 μg/mL TPC 농도에서 각각 89.86, 90.31, 91.92, 92.95%의 소거 활성을 나타내었다. As shown in FIG. 2a, in the case of the hot water extract, the scavenging activity was 86.35, 87.54, 89.10, and 89.24% at 25, 50, 75, and 100 μg/mL TPC concentrations, respectively, and in the case of the 50% ethanol extract, 25, Clearing activities of 89.86, 90.31, 91.92, and 92.95% were exhibited at 50, 75, and 100 μg/mL TPC concentrations, respectively.
이는 소인제 잎 추출물의 TPC 농도에 비례하여 DPPH 라디칼 소거 활성이 유의적으로 증가했음을 의미한다. 또한 양성 대조군으로 사용된 BHT는 같은 농도에서 5.09, 17.43, 24.82, 36.47%으로 나타났는바, 소인제 잎 추출물이 DPPH 라디칼에 대한 항산화 활성이 매우 우수한 것을 의미한다.This means that the DPPH radical scavenging activity significantly increased in proportion to the TPC concentration of the Soinje leaf extract. In addition, BHT used as a positive control was 5.09, 17.43, 24.82, and 36.47% at the same concentration, which means that the Soinje leaf extract has very excellent antioxidant activity against DPPH radicals.
2-2. ABTS 라디칼 억제 활성 확인2-2. Confirmation of ABTS radical inhibition activity
ABTS 라디칼 억제 활성 측정은 과황산칼륨(potassiun persulfate)과의 반응에 의해 생성되는 ABTS 라디칼이 추출물에 함유된 페놀 화합물의 항산화성에 의해 제거되고, 라디칼 특유의 청록색이 페놀 화합물의 라디칼 억제 활성으로 인해서 연한 녹색으로 탈색되는 것을 이용한 항산화 활성 측정 방법이다. 이에, 소인제 잎 추출물의 ABTS 라디칼 억제 활성을 확인하였다. 그 결과는 도 2b에 나타내었다.In the measurement of ABTS radical inhibitory activity, the ABTS radical generated by the reaction with potassium persulfate is removed by the antioxidant properties of the phenolic compound contained in the extract, and the blue-green color characteristic of the radical is pale due to the radical inhibitory activity of the phenolic compound. It is a method for measuring antioxidant activity using green discoloration. Thus, the ABTS radical inhibitory activity of the soinje leaf extract was confirmed. The results are shown in Figure 2b.
도 2b에 나타난 바와 같이, 열수 추출물은 25, 50, 75, 100 μg/mL의 TPC 농도에서 62.04, 95.86, 99.81, 100.03%의 항산화 활성을 나타내었고, 50% 에탄올 추출물은 25, 50, 75, 100 μg/mL의 TPC 농도에서 75.74, 99.66, 100.20, 100.03%의 항산화 활성을 나타내었다. 양성 대조군으로 사용한 BHT도 동일한 농도로 실험을 진행 하였을 때 0.22, 5.03, 2.75, 10.44%의 항산화 활성을 나타냈으므로, 소인제 잎 추출물이 BHT보다 월등히 높은 항산화 활성을 나타내었다. 이는 소인제 잎 추출물의 ABTS 라디칼에 대한 항산화 활성이 현저히 우수하다는 것을 의미한다.As shown in FIG. 2b, the hot water extract exhibited antioxidant activities of 62.04, 95.86, 99.81, and 100.03% at TPC concentrations of 25, 50, 75, and 100 μg/mL, and the 50% ethanol extract exhibited antioxidant activity of 25, 50, 75, Antioxidant activities of 75.74, 99.66, 100.20, and 100.03% were exhibited at the TPC concentration of 100 μg/mL. BHT used as a positive control also showed antioxidant activity of 0.22, 5.03, 2.75, and 10.44% when the experiment was conducted at the same concentration, so Soinje leaf extract showed significantly higher antioxidant activity than BHT. This means that the antioxidant activity of the soinje leaf extract against ABTS radicals is remarkably excellent.
2-3. PF 항산화 활성 확인 2-3. Confirmation of PF antioxidant activity
PF는 베타 카로틴 리놀레산(linoleate) 시스템을 이용한 항산화 효과 측정방법이다. 불포화 지방산의 산패 과정에서 생성된 자유 라디칼이 베타 카로틴을 산화시켜 베타 카로틴 특유의 색을 탈색시키게 되는데, 이 과정에서 산화된 베타 카로틴은 자유 라디칼의 연쇄 산화반응을 중단시켜 자유 라디칼의 반응성을 잃게 만든다. 이러한 원리를 이용하여 PF를 측정함으로써 소인제 잎 추출물의 항산화 효과를 확인하였다. 그 결과는 도 2c에 나타내었다.PF is an antioxidant effect measurement method using beta-carotene linoleate system. Free radicals generated in the process of rancidity of unsaturated fatty acids oxidize beta-carotene to decolorize beta-carotene. . By measuring PF using this principle, the antioxidant effect of Soinje leaf extract was confirmed. The results are shown in Figure 2c.
도 2c에 나타난 바와 같이, 열수 추출물은 25, 50, 75, 100 μg/mL의 TPC 농도에서 0.95 내지 1.08 PF를 나타내었고, 50% 에탄올 추출물에서는 0.92 내지 1.22 PF를 나타내었다. 열수 추출물과 50% 에탄올 추출물의 PF 측정 결과는 75 및 100 μg/mL의 TPC 농도에서 모두 양성 대조군인 BHT보다 우수하였고, 특히 50% 에탄올 추출물에서 다소 높은 것으로 확인하였다.As shown in Figure 2c, the hot water extract showed 0.95 to 1.08 PF at TPC concentrations of 25, 50, 75, and 100 μg/mL, and 0.92 to 1.22 PF at 50% ethanol extract. The PF measurement results of the hot water extract and the 50% ethanol extract were all superior to the positive control BHT at TPC concentrations of 75 and 100 μg/mL, and it was confirmed that the PF was slightly higher in the 50% ethanol extract.
2-4. TBARs 저해 활성 확인2-4. Confirmation of TBARs inhibitory activity
소인제 잎 추출물의 TBARs 저해 활성을 확인하였다. 그 결과는 도 2d에 나타내었다.The TBARs inhibitory activity of Soinje leaf extract was confirmed. The results are shown in Figure 2d.
도 2d에 나타난 바와 같이, 열수 추출물과 50% 에탄올 추출물에서 모두 양성 대조군인 BHT보다 다소 낮은 경향을 보였으나, 최고농도인 100 μg/mL의 TPC 농도에서는 열수 추출물과 50% 에탄올 추출물에서 모두 77.00% 이상의 지용성 항산화 활성을 나타내었으며, 농도의존적인 양상을 나타내었다.As shown in FIG. 2d, both the hot water extract and the 50% ethanol extract tended to be slightly lower than the positive control, BHT. The above fat-soluble antioxidant activity was shown, and a concentration-dependent pattern was shown.
상기 결과로부터 소인제 잎 추출물이 양성 대조군인인 BHT보다 수용성 및 지용성 항산화에 대한 높은 활성을 나타내며, 수용성 및 지용성 항산화 성분을 다량 함유하고 있다는 것을 알 수 있다.From the above results, it can be seen that the Soinje leaf extract exhibits higher activity against water-soluble and fat-soluble antioxidants than BHT, which is a positive control group, and contains a large amount of water-soluble and fat-soluble antioxidant components.
실험예 3. 소인제 추출물의 엘라스타제 저해 활성 확인Experimental Example 3. Confirmation of elastase inhibitory activity of soinje extract
인체의 피부탄력을 유지해주는 엘라스틴(elastin)을 분해하여 피부의 탄력을 감소시키고 주름을 생성시키는 효소인 엘라스타제(elastase)의 저해 활성을 25, 50, 75 및 100 μg/mL의 4가지 페놀 농도의 소인제 열수 추출물, 및 에탄올 추출물 처리 후 확인하였다. 그 결과는 도 3에 나타내었다.25, 50, 75, and 100 μg/mL of four phenols that inhibit elastase, an enzyme that reduces skin elasticity and creates wrinkles by decomposing elastin, which maintains skin elasticity in the human body. Concentrations of Soinje hot water extract and ethanol extract were confirmed after treatment. The results are shown in Figure 3.
도 3에 나타난 바와 같이, 열수 추출물에서는 엘라스타제 저해 효과가 나타나지 않았고, 50% 에탄올 추출물은 25, 50, 75, 100 μg/mL의 TPC 농도에서 각각 7.96, 37.36, 54.59, 69.03%의 저해 활성을 나타내었다. 양성 대조군인 우르솔산(ursolic acid)은 25, 50, 75, 100 μg/mL 농도에서 각각 9.84, 12.60, 19.07, 35.83%의 저해 활성을 나타냈는바, 소인제 잎 50% 에탄올 추출물이 엘라스타제 저해 효과가 현저히 우수한 것을 확인할 수 있다.As shown in FIG. 3, the hot water extract did not show an inhibitory effect on elastase, and the 50% ethanol extract had inhibitory activities of 7.96, 37.36, 54.59, and 69.03% at TPC concentrations of 25, 50, 75, and 100 μg/mL, respectively. showed The positive control, ursolic acid, showed inhibitory activities of 9.84, 12.60, 19.07, and 35.83% at concentrations of 25, 50, 75, and 100 μg/mL, respectively. It can be confirmed that the inhibitory effect is remarkably excellent.
실험예 4. 소인제 추출물의 콜라게나제 저해 활성 확인Experimental Example 4. Confirmation of Collagenase Inhibitory Activity of Soinje Extract
콜라겐은 엘라스틴과 함께 피부의 진피층을 구성하는 결합조직이다. 광노화의 원인인 자외선 또는 자연노화로 인해 콜라게나제의 활성이 증가하고 그에 따라 콜라겐도 분해가 되는데, 이로 인하여 주름이 유발 될 수 있다. 소인제 잎 추출물이 이러한 메커니즘을 억제하는지 확인하기 위해, 콜라게나제 저해 활성을 확인하였다. 그 결과는 도 4에 나타내었다.Collagen is a connective tissue constituting the dermis layer of the skin together with elastin. The activity of collagenase increases due to ultraviolet light or natural aging, which is the cause of photoaging, and collagen is also decomposed accordingly, which can cause wrinkles. In order to confirm whether the Soinje leaf extract inhibits this mechanism, the collagenase inhibitory activity was confirmed. The results are shown in FIG. 4 .
도 4에 나타난 바와 같이, 열수 추출물은 25, 50, 75, 100 μg/mL의 TPC농도에서 각각 4.26, 21.64, 22.50, 29.82%의 저해 활성을 내었고, 50% 에탄올 추출물은 18.21, 36.95, 51.12, 54.76%의 저해활성을 나타내었다. 또한, 양성대조군으로 사용한 EGCG는 25, 50, 75, 100 μg/mL 농도 당 20.62, 24.10, 30.10, 34.11%의 저해 활성을 나타냈다. 이는 열수 추출물보다는 높고 50% 에탄올 추출물보다는 낮은 콜라게나제 저해 활성으로, 50% 에탄올 추출물의 콜라게나제 저해 활성이 매우 뛰어난 것을 의미한다.As shown in FIG. 4, the hot water extract produced inhibitory activities of 4.26, 21.64, 22.50, and 29.82% at TPC concentrations of 25, 50, 75, and 100 μg/mL, respectively, and the 50% ethanol extract exhibited inhibitory activities of 18.21, 36.95, and 51.12 , and showed an inhibitory activity of 54.76%. In addition, EGCG used as a positive control showed inhibitory activity of 20.62, 24.10, 30.10, and 34.11% per concentration of 25, 50, 75, and 100 μg/mL. This means that the collagenase inhibitory activity of the 50% ethanol extract is very excellent, as the collagenase inhibitory activity is higher than that of the hot water extract and lower than that of the 50% ethanol extract.
상기 결과로부터 본 발명의 소인제 추출물이 엘라스타제 및 콜라게나제 저해 활성을 나타냄으로써, 피부 주름개선 효과를 나타내는 것을 알 수 있었다.From the above results, it was found that the soinje extract of the present invention exhibits elastase and collagenase inhibitory activity, thereby exhibiting a skin wrinkle improvement effect.
실험예 5. 소인제 추출물의 수렴(astringent) 효과 확인Experimental Example 5. Confirmation of astringent effect of soinje extract
Astringent는 기본적으로 주름이 움츠린다는 수렴의 의미가 있으며, Astringent 활성은 표면 조직을 조밀하게 만들어 세포막의 투과성을 감소시키는 효과가 있다고 알려져 있다. 이에 소인제 잎 추출물의 수렴효과를 확인하기 위해 astringent 활성을 측정하였다. 그 결과는 도 5에 나타내었다.Astringent basically has the meaning of convergence that wrinkles shrink, and Astringent activity is known to have the effect of reducing the permeability of the cell membrane by making the surface tissue dense. Therefore, the astringent activity was measured to confirm the astringent effect of the Soinje leaf extract. The results are shown in FIG. 5 .
도 5에 나타난 바와 같이, 열수 추출물은 200 μg/mL의 TPC 농도 에서 20.83%, 400 μg/mL에서 28.79%의 수렴효과를 나타내었다. 반면에, 50% 에탄올 추출물의 경우, 200μg/mL의 TPC 농도에서 89.82%, 400 μg/mL에서 100.00%에 도달하는 매우 높은 수렴효과를 나타내었다. 양성 대조군으로 사용한 타닌산(tannic acid)의 경우, 200, 및 400μg/mL에서 각각 53.45, 81.32%의 수렴 효과를 나타냈는바, 타닌산보다 소인제 잎 50% 에탄올 추출물의 수렴효과가 훨씬 더 우수한 것을 알 수 있다.As shown in FIG. 5, the hot water extract showed an astringent effect of 20.83% at a TPC concentration of 200 μg/mL and 28.79% at a concentration of 400 μg/mL. On the other hand, in the case of the 50% ethanol extract, it showed a very high astringent effect reaching 89.82% at a TPC concentration of 200 μg/mL and 100.00% at 400 μg/mL. In the case of tannic acid used as a positive control, the astringent effect of 53.45 and 81.32% was shown at 200 and 400 μg/mL, respectively. can
상기 결과로부터 소인제 추출물이 수렴효과가 우수하여, 모공축소 효과를 나타낸다는 것을 알 수 있다.From the above results, it can be seen that the soinje extract has an excellent astringent effect and exhibits a pore-reducing effect.
실험예 6. 소인제 추출물의 히알루로니다제 저해 활성 확인Experimental Example 6. Confirmation of Hyaluronidase Inhibitory Activity of Soinje Extract
히알루론산(hyaluronic acid)은 글루쿠론산(glucuronic acid)과 글루코사민(glucosamine)이 연속적으로 결합된 고분자 다당류이다. 고분자 형태의 히알루론산은 대식세포의 식세포 활성을 억제하여 염증을 억제하며, 소분자는 상처 치유 과정에서 염증을 형성한다. 이에, 소인제 추출물의 항염증 효과를 확인하기 위해 염증 유발에 관련이 있는 효소인 히알루로니다제(hyaluronidase)의 저해 활성을 50, 100, 200 및 400 μg/mL의 4가지 페놀 농도의 소인제 열수 추출물, 및 50% 에탄올 추출물 처리 후 확인하였다. 그 결과는 도 6에 나타내었다.Hyaluronic acid is a high-molecular polysaccharide in which glucuronic acid and glucosamine are continuously linked. Hyaluronic acid in the form of a polymer suppresses inflammation by inhibiting the phagocytic activity of macrophages, and small molecules form inflammation during wound healing. Therefore, in order to confirm the anti-inflammatory effect of the soybean extract, the inhibitory activity of hyaluronidase, an enzyme related to the induction of inflammation, was tested in four phenolic concentrations of 50, 100, 200 and 400 μg / mL. It was confirmed after treatment with hot water extract and 50% ethanol extract. The results are shown in FIG. 6 .
도 6에 나타난 바와 같이, 열수 추출물은 50, 100, 200, 400 μg/mL TPC 농도에서 16.91 내지 85.00%의 저해활성, 50% 에탄올 추출물은 9.30 내지 99.12%의 저해 활성을 나타내었다. 양성 대조군으로 사용한 PDTC의 경우, 동일 농도 구간에서 9.80 내지 89.72%의 저해 활성을 나타내었다. 이는 소인제 잎 열수 추출물, 및 50% 에탄올 추출물은 모두 염증반응에 관여하는 주요효소인 히알루로니다제의 활성을 저해시키는 우수한 효과가 있다는 것을 의미한다.As shown in FIG. 6, the hot water extract exhibited inhibitory activity of 16.91 to 85.00% at concentrations of 50, 100, 200, and 400 μg/mL TPC, and the 50% ethanol extract exhibited inhibitory activity of 9.30 to 99.12%. In the case of PDTC used as a positive control, the inhibitory activity was 9.80 to 89.72% in the same concentration range. This means that both the hot water extract of Soinje leaf and the 50% ethanol extract have an excellent effect of inhibiting the activity of hyaluronidase, a major enzyme involved in the inflammatory response.
또한, 고분자의 히알루론산은 피부의 수분함량을 높여주고 유지하는 보습 효과가 있는 것으로 알려져 있는 바, 상기 소인제 추출물의 히알루로니다제 저해 활성을 통해 항염증 효과 및 보습 효과를 갖는 미용 소재로의 응용 가능성을 확인하였다.In addition, it is known that high-molecular hyaluronic acid has a moisturizing effect of increasing and maintaining the moisture content of the skin. Through the hyaluronidase inhibitory activity of the soinje extract, it can be used as a cosmetic material having anti-inflammatory and moisturizing effects. Applicability was confirmed.
전술한 본 발명의 설명은 예시를 위한 것이며, 본 발명이 속하는 기술분야의 통상의 지식을 가진 자는 본 발명의 기술적 사상이나 필수적인 특징을 변경하지 않고서 다른 구체적인 형태로 쉽게 변형이 가능하다는 것을 이해할 수 있을 것이다. 그러므로 이상에서 기술한 실시예들은 모든 면에서 예시적인 것이며 한정적이 아닌 것으로 이해해야 한다.The above description of the present invention is for illustrative purposes, and those skilled in the art can understand that it can be easily modified into other specific forms without changing the technical spirit or essential features of the present invention. will be. Therefore, it should be understood that the embodiments described above are illustrative in all respects and not restrictive.
Claims (13)
Soinje ( Aeonium sediforium ) Containing an extract as an active ingredient, for antioxidant; for anti-inflammatory use; for pore reduction; Or a cosmetic composition for preventing and improving wrinkles.
상기 소인제 추출물은 소인제 잎 추출물인 것을 특징으로 하는, 화장료 조성물.
According to claim 1,
Characterized in that the soinje extract is a soinje leaf extract, a cosmetic composition.
상기 소인제 추출물은 DPPH(1,1-diphenyl-2-picrylhydrazyl) 라디칼 저해, ABTS(2,2’-Azinobis-(3-ethylbenzothiazoline-6-sulfonic acid) 라디칼 저해, TBARs(Thiobarbituric acid reactive substances) 저해, 또는 PF(Antioxidant protection factor) 증가 활성을 가지는 것을 특징으로 하는, 화장료 조성물.
According to claim 1,
The soinje extract inhibits DPPH (1,1-diphenyl-2-picrylhydrazyl) radical, ABTS (2,2'-Azinobis-(3-ethylbenzothiazoline-6-sulfonic acid) radical inhibition, and TBARs (Thiobarbituric acid reactive substances) inhibition , or PF (Antioxidant protection factor) characterized in that it has an increasing activity, a cosmetic composition.
상기 소인제 추출물은 하기 특징 중 하나 이상을 만족하는 것을 특징으로 하는, 화장료 조성물:
(a) 히알루로니다제(hyaluronidase)를 저해;
(b) 수렴작용(astringent)을 나타냄; 및
(c) 엘라스타제(elastase) 또는 콜라게나제(collagenase)를 저해.
According to claim 1,
The cosmetic composition, characterized in that the soinje extract satisfies one or more of the following characteristics:
(a) inhibit hyaluronidase;
(b) exhibits astringent action; and
(c) inhibition of elastase or collagenase.
상기 소인제 추출물은 물, C1 내지 C4의 저급알코올, n-헥산, 에틸아세테이트, 아세톤, 아세토니트릴, 부틸아세테이트, 1,3-부틸렌 글리콜, 메틸렌클로라이드, 및 이들의 혼합용매로 구성된 군으로부터 선택된 용매로 추출된 것을 특징으로 하는, 화장료 조성물.
According to claim 1,
The disinfectant extract is a group consisting of water, C 1 to C 4 lower alcohol, n-hexane, ethyl acetate, acetone, acetonitrile, butyl acetate, 1,3-butylene glycol, methylene chloride, and mixed solvents thereof Characterized in that extracted with a solvent selected from, a cosmetic composition.
Soinje ( Aeonium sediforium ) Containing an extract as an active ingredient, for antioxidant; for anti-inflammatory use; for pore reduction; Or a food composition for preventing and improving wrinkles.
상기 소인제 추출물은 소인제 잎 추출물인 것을 특징으로 하는, 식품 조성물.
According to claim 6,
The soinje extract is characterized in that the soinje leaf extract, food composition.
상기 소인제 추출물은 DPPH(1,1-diphenyl-2-picrylhydrazyl) 라디칼 저해, ABTS(2,2’-Azinobis-(3-ethylbenzothiazoline-6-sulfonic acid) 라디칼 저해, TBARs(Thiobarbituric acid reactive substances) 저해, 또는 PF(Antioxidant protection factor) 증가 활성을 가지는 것을 특징으로 하는, 식품 조성물.
According to claim 6,
The soinje extract inhibits DPPH (1,1-diphenyl-2-picrylhydrazyl) radical, ABTS (2,2'-Azinobis-(3-ethylbenzothiazoline-6-sulfonic acid) radical inhibition, and TBARs (Thiobarbituric acid reactive substances) inhibition , or PF (Antioxidant protection factor) characterized in that it has an increasing activity, food composition.
상기 소인제 추출물은 하기 특징 중 하나 이상을 만족하는 것을 특징으로 하는, 식품 조성물:
(a) 히알루로니다제(hyaluronidase)를 저해;
(b) 수렴작용(astringent)을 나타냄; 및
(c) 엘라스타제(elastase) 또는 콜라게나제(collagenase)를 저해.
According to claim 6,
The food composition, characterized in that the soinje extract satisfies one or more of the following characteristics:
(a) inhibit hyaluronidase;
(b) exhibits astringent action; and
(c) inhibition of elastase or collagenase.
상기 소인제 추출물은 물, C1 내지 C4의 저급알코올, n-헥산, 에틸아세테이트, 아세톤, 아세토니트릴, 부틸아세테이트, 1,3-부틸렌 글리콜, 메틸렌클로라이드, 및 이들의 혼합용매로 구성된 군으로부터 선택된 용매로 추출된 것을 특징으로 하는, 식품 조성물.
According to claim 6,
The disinfectant extract is a group consisting of water, C 1 to C 4 lower alcohol, n-hexane, ethyl acetate, acetone, acetonitrile, butyl acetate, 1,3-butylene glycol, methylene chloride, and mixed solvents thereof Characterized in that extracted with a solvent selected from, a food composition.
Soinje ( Aeonium sediforium ) Containing an extract as an active ingredient, for antioxidant; Or a pharmaceutical composition for anti-inflammatory.
상기 소인제 추출물은 DPPH(1,1-diphenyl-2-picrylhydrazyl) 라디칼 저해, ABTS(2,2’-Azinobis-(3-ethylbenzothiazoline-6-sulfonic acid) 라디칼 저해, TBARs(Thiobarbituric acid reactive substances) 저해, 또는 PF(Antioxidant protection factor) 증가 활성을 가지는 것을 특징으로 하는, 약학적 조성물.
According to claim 11,
The soinje extract inhibits DPPH (1,1-diphenyl-2-picrylhydrazyl) radical, ABTS (2,2'-Azinobis-(3-ethylbenzothiazoline-6-sulfonic acid) radical inhibition, and TBARs (Thiobarbituric acid reactive substances) inhibition , Or PF (Antioxidant protection factor) characterized in that it has an increasing activity, a pharmaceutical composition.
상기 소인제 추출물은 히알루로니다제(hyaluronidase)를 저해하는 것을 특징으로 하는, 약학적 조성물.According to claim 11,
The soinje extract is characterized in that inhibiting hyaluronidase (hyaluronidase), a pharmaceutical composition.
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KR100767974B1 (en) | 2006-05-30 | 2007-10-18 | (주)더페이스샵코리아 | A cosmetic composition for reducing the skin pore containing arctium lappa extracts and cold materials |
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KR100767974B1 (en) | 2006-05-30 | 2007-10-18 | (주)더페이스샵코리아 | A cosmetic composition for reducing the skin pore containing arctium lappa extracts and cold materials |
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KR20230099141A (en) * | 2021-12-27 | 2023-07-04 | 호서대학교 산학협력단 | Composition for preventing or treating cancer with Aeonium arboreum as an active ingredient |
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