KR20230051127A - 특정 화학 조성물 및 이의 사용 방법 - Google Patents

특정 화학 조성물 및 이의 사용 방법 Download PDF

Info

Publication number
KR20230051127A
KR20230051127A KR1020227043684A KR20227043684A KR20230051127A KR 20230051127 A KR20230051127 A KR 20230051127A KR 1020227043684 A KR1020227043684 A KR 1020227043684A KR 20227043684 A KR20227043684 A KR 20227043684A KR 20230051127 A KR20230051127 A KR 20230051127A
Authority
KR
South Korea
Prior art keywords
alkyl
cycloalkyl
compound
amino
aryl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
KR1020227043684A
Other languages
English (en)
Korean (ko)
Inventor
안드레이 더블유 콘라디
춘-하오 후앙
코-추안 리
Original Assignee
알젠 바이오테크놀로지스, 인크.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 알젠 바이오테크놀로지스, 인크. filed Critical 알젠 바이오테크놀로지스, 인크.
Publication of KR20230051127A publication Critical patent/KR20230051127A/ko
Pending legal-status Critical Current

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Plural Heterocyclic Compounds (AREA)
KR1020227043684A 2020-05-15 2021-05-14 특정 화학 조성물 및 이의 사용 방법 Pending KR20230051127A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202063025474P 2020-05-15 2020-05-15
US63/025,474 2020-05-15
PCT/US2021/032495 WO2021231892A1 (en) 2020-05-15 2021-05-14 Certain chemical compositions and methods of use thereof

Publications (1)

Publication Number Publication Date
KR20230051127A true KR20230051127A (ko) 2023-04-17

Family

ID=76270111

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020227043684A Pending KR20230051127A (ko) 2020-05-15 2021-05-14 특정 화학 조성물 및 이의 사용 방법

Country Status (12)

Country Link
US (2) US11591322B2 (https=)
EP (1) EP4149941B1 (https=)
JP (1) JP2023526332A (https=)
KR (1) KR20230051127A (https=)
CN (1) CN116261561B (https=)
AU (1) AU2021273072A1 (https=)
BR (1) BR112022023199A2 (https=)
CA (1) CA3178813A1 (https=)
ES (1) ES3054109T3 (https=)
IL (1) IL298219A (https=)
MX (1) MX2022014356A (https=)
WO (1) WO2021231892A1 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES3054109T3 (en) 2020-05-15 2026-01-29 Algen Biotechnologies Inc Certain chemical compositions and methods of use thereof
WO2023086417A1 (en) * 2021-11-11 2023-05-19 Algen Biotechnologies, Inc. Compounds and methods of use thereof

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4932412A (en) 1986-12-18 1990-06-12 Immunomedics, Inc. Intraoperative and endoscopic tumor detection and therapy
EP1223952B1 (en) 1999-10-07 2008-04-16 Carlos Estuardo Aguilar-Cordova Methods for treatment of solid tumors and metastasis by gene therapy
WO2004110350A2 (en) 2003-05-14 2004-12-23 Torreypines Therapeutics, Inc. Compouds and uses thereof in modulating amyloid beta
WO2006071958A1 (en) 2004-12-29 2006-07-06 Millennium Pharmaceuticals, Inc. Compounds useful as chemokine receptor antagonists
US8415381B2 (en) 2009-07-30 2013-04-09 Novartis Ag Heteroaryl compounds and their uses
WO2012101065A2 (en) * 2011-01-28 2012-08-02 Novartis Ag Pyrimidine biaryl amine compounds and their uses
WO2012101063A1 (en) * 2011-01-28 2012-08-02 Novartis Ag N-acyl pyridine biaryl compounds and their uses
CN103339110A (zh) * 2011-01-28 2013-10-02 诺瓦提斯公司 作为cdk9抑制剂的取代的杂-联芳基化合物及其用途
WO2012101066A1 (en) 2011-01-28 2012-08-02 Novartis Ag Pyridine biaryl amine compounds and their uses
US9013997B2 (en) 2012-06-01 2015-04-21 Broadcom Corporation System for performing distributed data cut-through
EP3126525B1 (en) 2014-04-04 2020-02-19 Memorial Sloan-Kettering Cancer Center Method and kits for identifying of cdk9 inhibitors for the treatment of cancer
NZ734082A (en) 2015-01-20 2019-01-25 Boehringer Ingelheim Animal Health Usa Inc Anthelmintic compounds, compositions and method of using thereof
PL3429591T3 (pl) 2016-03-16 2023-07-17 Kura Oncology, Inc. Podstawione pochodne tieno[2,3-d]pirymidyny jako inhibitory meniny-mll i metody ich zastosowania
EP3874045A4 (en) 2018-10-31 2022-09-07 The Regents of The University of California Methods and kits for identifying cancer treatment targets
CN114025772A (zh) 2019-04-24 2022-02-08 纪念斯隆凯特琳癌症中心 用于治疗ras突变体癌症的组合物和方法
JP7677914B2 (ja) 2019-06-21 2025-05-15 アルゲン バイオテクノロジーズ，インク． 標的遺伝子を特定するための方法およびシステム
EP4126918A4 (en) 2020-03-31 2024-05-29 The Regents of the University of California COMPOSITIONS AND METHODS FOR IDENTIFYING HOST CELL TARGET PROTEINS FOR THE TREATMENT OF RNA VIRUS INFECTIONS
ES3054109T3 (en) 2020-05-15 2026-01-29 Algen Biotechnologies Inc Certain chemical compositions and methods of use thereof
EP4185867A4 (en) 2020-07-22 2024-08-07 Algen Biotechnologies, Inc. Methods and systems for determining drug effectiveness
WO2023086417A1 (en) 2021-11-11 2023-05-19 Algen Biotechnologies, Inc. Compounds and methods of use thereof

Also Published As

Publication number Publication date
CN116261561A (zh) 2023-06-13
US20220289725A1 (en) 2022-09-15
US20230295135A1 (en) 2023-09-21
EP4149941A1 (en) 2023-03-22
CA3178813A1 (en) 2021-11-18
US12264152B2 (en) 2025-04-01
AU2021273072A1 (en) 2022-12-15
BR112022023199A2 (pt) 2023-04-04
ES3054109T3 (en) 2026-01-29
IL298219A (en) 2023-01-01
US11591322B2 (en) 2023-02-28
CN116261561B (zh) 2025-10-31
JP2023526332A (ja) 2023-06-21
MX2022014356A (es) 2023-03-09
WO2021231892A1 (en) 2021-11-18
EP4149941B1 (en) 2025-09-03

Similar Documents

Publication Publication Date Title
JP6468611B2 (ja) キナーゼ阻害のためのヘテロアリール化合物
ES2900184T3 (es) Combinaciones terapéuticas de un inhibidor de BTK y un inhibidor de BCL-2
RU2638540C1 (ru) Ингибиторы днк-пк
WO2023279041A1 (en) Indazole compounds
WO2021061644A1 (en) Novel substituted quinoline-8-carbonitrile derivatives with androgen receptor degradation activity and uses thereof
IL256250A (en) Hpk1 inhibitors and methods of using them
JP6863901B2 (ja) キナーゼ阻害のためのヘテロアリール化合物
CA2935071A1 (en) Piperidine-dione derivatives
WO2015051341A1 (en) Inhibitors of erk and methods of use
CN116888108A (zh) 新型egfr降解剂
EP3283487B1 (en) Pyridopyrimidinones and their use as nmda receptor modulators
TW201823246A (zh) Cdk4/6抑制劑
JP2024517861A (ja) ＰＫＣ－θモジュレーター
US12264152B2 (en) Certain chemical compositions and methods of use thereof
EP3856743A1 (en) Substituted imidazo [1, 2-a] pyridine and [1, 2, 4] triazolo [1, 5-a] pyridine compounds as ret kinase inhibitors
EP4547658A1 (en) Wee1 degrading compounds and uses thereof
TW202010500A (zh) 作為a2a受體拮抗劑的吡唑並三唑並嘧啶衍生物
US11622970B2 (en) BCL-2 inhibitors and their use as pharmaceuticals
JP7822308B2 (ja) 固形腫瘍の処置のための組成物
WO2024220866A1 (en) Novel aminopyrimidine derivatives as cyclin-dependent kinase inhibitors
KR102805772B1 (ko) 중추 및 말초 신경계 장애 치료를 위한 키나제 억제제
US20250161289A1 (en) KAT6 Targeting Compounds
KR20230153959A (ko) 신규한 pim 키나아제 억제 화합물 및 이의 용도
WO2025232887A1 (en) Wee1 degraders and uses thereof
HK1255833B (en) Hpk1 inhibitors and methods of using same

Legal Events

Date Code Title Description
PA0105 International application

St.27 status event code: A-0-1-A10-A15-nap-PA0105

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

PG1501 Laying open of application

St.27 status event code: A-1-1-Q10-Q12-nap-PG1501

A201 Request for examination
E13-X000 Pre-grant limitation requested

St.27 status event code: A-2-3-E10-E13-lim-X000

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

PA0201 Request for examination

St.27 status event code: A-1-2-D10-D11-exm-PA0201

D21 Rejection of application intended

Free format text: ST27 STATUS EVENT CODE: A-1-2-D10-D21-EXM-PE0902 (AS PROVIDED BY THE NATIONAL OFFICE)

PE0902 Notice of grounds for rejection

St.27 status event code: A-1-2-D10-D21-exm-PE0902

T11-X000 Administrative time limit extension requested

St.27 status event code: U-3-3-T10-T11-oth-X000