KR20230038234A - 만성 신장 질환 치료를 위한 지보텐탄 및 다파글리플로진의 조합 - Google Patents

만성 신장 질환 치료를 위한 지보텐탄 및 다파글리플로진의 조합 Download PDF

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Publication number
KR20230038234A
KR20230038234A KR1020237004545A KR20237004545A KR20230038234A KR 20230038234 A KR20230038234 A KR 20230038234A KR 1020237004545 A KR1020237004545 A KR 1020237004545A KR 20237004545 A KR20237004545 A KR 20237004545A KR 20230038234 A KR20230038234 A KR 20230038234A
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KR
South Korea
Prior art keywords
human patient
patient
ckd
zibotentan
further embodiment
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Pending
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KR1020237004545A
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English (en)
Korean (ko)
Inventor
피터 그리즐리
크리스틴 알스트룀
스탄코 스크르틱
로버트 멘지스
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아스트라제네카 아베
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Publication of KR20230038234A publication Critical patent/KR20230038234A/ko
Pending legal-status Critical Current

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965Non-condensed pyrazines
    • A61K31/497Non-condensed pyrazines containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/351Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom not condensed with another ring
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Urology & Nephrology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
KR1020237004545A 2020-07-10 2021-07-09 만성 신장 질환 치료를 위한 지보텐탄 및 다파글리플로진의 조합 Pending KR20230038234A (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US202063050147P 2020-07-10 2020-07-10
US63/050,147 2020-07-10
US202163196793P 2021-06-04 2021-06-04
US63/196,793 2021-06-04
PCT/IB2021/056177 WO2022009163A1 (en) 2020-07-10 2021-07-09 Combination of zibotentan and dapagliflozin for the treatment of chronic kidney disease

Publications (1)

Publication Number Publication Date
KR20230038234A true KR20230038234A (ko) 2023-03-17

Family

ID=76959008

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020237004545A Pending KR20230038234A (ko) 2020-07-10 2021-07-09 만성 신장 질환 치료를 위한 지보텐탄 및 다파글리플로진의 조합

Country Status (18)

Country Link
US (4) US11730735B2 (https=)
EP (1) EP4178578A1 (https=)
JP (1) JP7814368B2 (https=)
KR (1) KR20230038234A (https=)
CN (2) CN119386017A (https=)
AU (2) AU2021305983B2 (https=)
BR (1) BR112023000406A2 (https=)
CA (1) CA3188345A1 (https=)
CL (1) CL2023000097A1 (https=)
CR (1) CR20230083A (https=)
DO (1) DOP2022000301A (https=)
IL (1) IL299568A (https=)
MX (1) MX2023000276A (https=)
PE (1) PE20230778A1 (https=)
PH (1) PH12023550025A1 (https=)
TW (1) TWI900606B (https=)
UY (1) UY39321A (https=)
WO (1) WO2022009163A1 (https=)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2022009163A1 (en) * 2020-07-10 2022-01-13 Astrazeneca Ab Combination of zibotentan and dapagliflozin for the treatment of chronic kidney disease
AU2023321653A1 (en) * 2022-08-12 2025-03-27 Astrazeneca Ab Combination therapies for treatment of cirrhosis with portal hypertension
UY40633A (es) * 2023-02-08 2024-07-31 Astrazeneca Ab Combinación de zibotentán y dapagliflozina para el tratamiento de la enfermedad renal crónica con pr
WO2025133907A1 (en) * 2023-12-18 2025-06-26 Astrazeneca Ab Combination of zibotentan and dapagliflozin for the treatment of microvascular angina
WO2025163559A1 (en) 2024-02-01 2025-08-07 Astrazeneca Ab Combination of zibotentan and dapagliflozin for use for the treatment of hypertension
WO2025261457A1 (zh) * 2024-06-21 2025-12-26 深圳信立泰药业股份有限公司 内皮素a(eta)受体拮抗剂联用sglt-2抑制剂的医药用途
WO2026078068A1 (en) * 2024-10-09 2026-04-16 Astrazeneca Ab Combination of zibotentan and dapagliflozin for the treatment of chronic kidney disease and liver fibrosis

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA58494C2 (uk) 1995-06-07 2003-08-15 Зенека Лімітед Похідні n-гетероарилпіридинсульфонаміду, фармацевтична композиція, спосіб одержання та спосіб протидії впливам ендотеліну
US6515117B2 (en) 1999-10-12 2003-02-04 Bristol-Myers Squibb Company C-aryl glucoside SGLT2 inhibitors and method
EP2545920A1 (en) 2007-08-22 2013-01-16 Abbott GmbH & Co. KG Therapy for complications of diabetes
US9364458B2 (en) 2013-07-08 2016-06-14 Abbvie Inc. Stabilized pharmaceutical dosage forms comprising atrasentan
US8962675B1 (en) 2013-09-12 2015-02-24 Abbvie Inc. Atrasentan mandelate salts
FI3658140T3 (fi) 2017-02-27 2025-08-12 Idorsia Pharmaceuticals Ltd Aprositentaanin yhdistelmiä muiden vaikuttavien ainesosien kanssa resistentin verenpainetaudin hoitamiseksi
CN111405899B (zh) 2017-11-30 2025-05-16 爱杜西亚药品有限公司 用于治疗内皮素相关疾病的4-嘧啶磺酰胺衍生物与sglt-2抑制剂的组合
US20210338648A1 (en) * 2018-10-01 2021-11-04 Astrazeneca Ab Methods and compositions for reducing serum uric acid
IL297208A (en) 2020-04-10 2022-12-01 Chinook Therapeutics Inc Treatment methods for diabetic kidney disease
WO2022009163A1 (en) * 2020-07-10 2022-01-13 Astrazeneca Ab Combination of zibotentan and dapagliflozin for the treatment of chronic kidney disease
US12409186B2 (en) 2020-07-27 2025-09-09 Astrazeneca Ab Methods of treating chronic kidney disease with dapagliflozin

Also Published As

Publication number Publication date
PH12023550025A1 (en) 2024-03-11
CN115803028A (zh) 2023-03-14
CA3188345A1 (en) 2022-01-13
BR112023000406A2 (pt) 2023-01-31
TWI900606B (zh) 2025-10-11
AU2024204913A1 (en) 2024-08-01
EP4178578A1 (en) 2023-05-17
US20240358698A1 (en) 2024-10-31
IL299568A (en) 2023-02-01
JP2023541766A (ja) 2023-10-04
US20260027112A1 (en) 2026-01-29
CN119386017A (zh) 2025-02-07
US11730735B2 (en) 2023-08-22
US20230364077A1 (en) 2023-11-16
TW202216147A (zh) 2022-05-01
AU2021305983A1 (en) 2023-03-02
WO2022009163A1 (en) 2022-01-13
AU2021305983B2 (en) 2024-05-16
CL2023000097A1 (es) 2023-09-01
CR20230083A (es) 2023-05-16
PE20230778A1 (es) 2023-05-09
US20220023295A1 (en) 2022-01-27
UY39321A (es) 2022-01-31
JP7814368B2 (ja) 2026-02-16
US12409174B2 (en) 2025-09-09
DOP2022000301A (es) 2023-01-31
US12121517B2 (en) 2024-10-22
MX2023000276A (es) 2023-02-09

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