KR20230034356A

KR20230034356A - 활성이 감소된 glp-1r 효능제 펩티드

Info

Publication number: KR20230034356A
Application number: KR1020237003787A
Authority: KR
Inventors: 마르크 소머펠트; 토마스 랑거; 올리버 보샤이넨; 우베 슈반; 베르너 디트리히; 크리스티네 루돌프; 안드레아스 에버스
Original assignee: 사노피
Priority date: 2020-07-02
Filing date: 2020-07-02
Publication date: 2023-03-09
Also published as: CA3184544A1; JP2023540662A; US20230250147A1; EP4175980A1; CN116113639A; WO2022002409A1

Abstract

본 발명은 감소된 글루카곤-유사 펩티드-1 수용체(GLP-1R) 효능제 활성을 갖는 GLP-1R 효능제 펩티드, 및 이를 포함하는 융합 분자에 관한 것이다. 본 발명은 또한 감소된 GLP-1R 효능제 활성을 갖는 GLP-1R 효능제 펩티드를 인코딩하는 핵산 분자, 감소된 GLP-1R 효능제 활성을 갖는 GLP-1R 효능제 펩티드를 포함하는 약제학적 조성물 및 조합물, 및 감소된 GLP-1R 효능제 활성을 갖는 GLP-1R 효능제 펩티드를 포함하는 키트에 관한 것이다. 본 발명은 또한 특히 비만, 과체중, 대사 증후군, 진성 당뇨병, 당뇨병성 망막병증, 고혈당증, 이상지질혈증, NASH 및/또는 죽상경화증의 치료를 위한, 의약으로서의 감소된 GLP-1R 효능제 활성을 갖는 GLP-1R 효능제 펩티드의 용도에 관한 것이다.

Description

활성이 감소된 GLP-1R 효능제 펩티드

본 발명은 감소된 GLP-1R 효능제(agonistic) 활성을 갖는 GLP-1R(글루카곤-유사 펩티드-1 수용체) 효능제 펩티드, 이를 포함하는 조합물 및 융합 분자뿐만 아니라, 상응하는 핵산 분자, 약제학적 조성물 및 키트에 관한 것이다. 또한 본 발명은 특히 비만, 과체중, 대사 증후군, 진성 당뇨병, 당뇨병성 망막병증, 고혈당증, 이상지질혈증, 비알코올성 지방간염(NASH) 및/또는 죽상동맥경화증의 치료를 위한 약제로서의 GLP-1R 효능제 펩티드의 용도에 관한 것이다.

GLP-1R 효능제 펩티드의 단독 사용 또는 다른 활성 약제학적 성분과의 조합사용은 단점을 가질 수 있다. GLP-1R 효능제 펩티드는 낮은 혈장 수준에서 이미 약제학적으로 효과적이다. 더 높은 혈장 수준에서, GLP-1(1차 GLP-1R 효능제)은, 예를 들어, 오심과 구토를 유발하는 부작용이 있는 것으로 알려져 있다. 대조적으로, GLP-1R 효능제 펩티드, 예를 들어, 섬유아세포 성장 인자 21(FGF21) 화합물과 조합될 수 있는 다른 활성 약제학적 성분의 약리학적 효과는 약리학적 효과를 발휘하는 GLP-1의 혈장 수준보다 더 높은 혈장 수준에서 종종 관찰된다. 종합하면, 이것은 GLP-1R 효능제 펩티드를 단독으로 또는 융합 분자의 형태로, 다른 활성 약제학적 성분, 예를 들어, FGF21 화합물 및 GLP-1R 효능제 펩티드와 조합하여 투여할 때 GLP-1-매개 부작용의 위험을 나타낸다. 따라서 이러한 난제를 극복할 수 있는 새로운 GLP-1R 효능제 펩티드가 요구된다.

본 발명의 목적은 GLP-1R 효능제 활성이 감소된 GLP-1R 효능제 펩티드를 제공하는 것이다. 이러한 GLP-1R 효능제 펩티드는, 예를 들어, 잠재적 부작용(예를 들어, 오심 및/또는 구토 등)을 피하면서 두 활성 작용제의 유익한 효과(예를 들어, 체중, 지질 및/또는 혈당 조절 등의 관점에서)를 달성하기 위해 GLP-1R 효능제/FGF21 화합물 활성 비율의 균형을 맞추는 데 사용될 수 있다.

일 양태에서, 본 발명은 천연 GLP-1(7-36)(서열번호: 260)의 GLP-1R 효능제 활성과 비교하여 약 9배 내지 약 531배 감소된 GLP-1R 효능제 활성을 갖는 GLP-1R 효능제 펩티드에 관한 것으로, 상기 GLP-1R 효능제 펩티드는 하기 아미노산 서열

X₁-G-E-G-T-F-T-S-D-X₁₀-S-X₁₂-X₁₃-L-X₁₅-X₁₆-X₁₇-X₁₈-X₁₉-X₂₀-X₂₁-F-X₂₃-E-W-L-X₂₇-X₂₈-X₂₉-G(서열번호: 635)

을 포함하거나 또는 이들로 이루어지고,

여기서

X₁은 H, Y 또는 F이고,

X₁₀은 K 또는 L이고,

X₁₂는 K, I 또는 Q이고,

X₁₃은 Q 또는 L이고,

X₁₅는 E, A 또는 D이고,

X₁₆은 E, K 또는 S이고,

X₁₇은 E, R 또는 Q이고,

X₁₈은 L, A 또는 R이고,

X₁₉는 V, A 또는 F이고,

X₂₀은 R, H, Q, K 또는 I이고,

X₂₁은 L, E, H 또는 R이고,

X₂₃은 I, Y 또는 F이고,

X₂₇은 I, L, K 또는 E이고,

X₂₈은 A, K, N 또는 E이고,

X₂₉는 G, T, K 또는 V이고;

선택적으로, 상기 아미노산 서열은 N-말단에 적어도 하나의 추가 아미노산 잔기를 추가로 포함하고;

선택적으로, 아미노산 서열은 C-말단에 최대 약 12개, 약 11개 또는 약 10개의 아미노산 잔기로 이루어진 펩티드 연장부를 추가로 포함한다.

일 구현예에서, GLP-1R 효능제 펩티드는 하기 아미노산 서열

H-G-E-G-T-F-T-S-D-X₁₀-S-K-Q-L-E-E-E-X₁₈-V-X₂₀-L-F-I-E-W-L-K-A-X₂₉-G(서열번호: 636)을 포함하거나 또는 이들로 이루어지고,

여기서

X₁₀은 K 또는 L이고,

X₁₈은 A 또는 R이고,

X₂₀은 R 또는 Q이고,

X₂₉는 G 또는 T이고;

선택적으로, 상기 아미노산 서열은 C-말단에 최대 약 12개, 약 11개 또는 약 10개의 아미노산 잔기로 이루어진 펩티드 연장부를 추가로 포함한다.

일 구현예에서, 적어도 하나의 추가 아미노산 잔기는 G 또는 A이다. 일 구현예에서, 적어도 하나의 추가 아미노산 잔기는 단일 아미노산 잔기이다. 일 구현예에서, 적어도 하나의 추가 아미노산 잔기는 G이다.

일 구현예에서, 펩티드 연장부는 서열번호: 566 내지 621로 이루어진 군으로부터 선택되는 아미노산 서열을 포함하거나 또는 이들로 이루어진다. 일 구현예에서, 펩티드 연장부는 단일 아미노산 잔기, 예를 들어, P이다. 일 구현예에서, 펩티드 연장부는 아미노산 서열 PSSGAPPPS(서열번호: 605) 또는 PKKIRYS(서열번호: 598)를 포함하거나 또는 이들로 이루어진다.

또 다른 양태에서, 본 발명은 천연 GLP-1(7-36)(서열번호: 260)의 GLP-1R 효능제 활성과 비교하여 약 9배 내지 약 531배 감소된 GLP-1R 효능제 활성을 갖는 GLP-1R 효능제 펩티드에 관한 것이며, 여기서 GLP-1R 효능제 펩티드는 서열번호: 261 내지 552 및 554 내지 565로 이루어진 군으로부터 선택되는 아미노산 서열, 또는 최대 3개의 아미노산 잔기 치환을 갖는, 서열번호: 261 내지 552 및 554 내지 565로 이루어진 군으로부터 선택되는 아미노산 서열을 포함하거나 또는 이들로 이루어진다.

일 구현예에서, GLP-1R 효능제 펩티드는, GLP-1R 효능제 펩티드가 분리된 형태인 경우 및/또는 GLP-1R 효능제 펩티드가 융합 분자의 일부인 경우, 천연 GLP-1(7-36)(서열번호: 260)의 GLP-1R 효능제 활성과 비교하여 약 9배 내지 약 531배 감소된 GLP-1R 효능제 활성을 갖는다.

일 구현예에서, GLP-1R 효능제 펩티드는, 천연 GLP-1(7-36)의 GLP-1R 효능제 활성과 비교하여 약 9배 내지 약 482배(또는 약 9.449배 내지 약 482.396배) 또는 약 9배 내지 약 319배(또는 약 9.449배 내지 약 319.311배) 또는 약 9배 내지 약 121배(또는 약 9.449배 내지 약 121.189배) 감소된 GLP-1R 효능제 활성을 갖는다.

일 구현예에서, GLP-1R 효능제 펩티드는, 천연 GLP-1(7-36)의 GLP-1R 효능제 활성과 비교하여 약 9배 내지 약 319배 감소된 GLP-1R 효능제 활성을 갖는다.

일 구현예에서, GLP-1R 효능제 펩티드는 천연 GLP-1(7-36)의 GLP-1R 효능제 활성과 비교하여 적어도 약 9.4배 또는 적어도 약 9.45배 또는 적어도 약 9.5배 감소된 GLP-1R 효능제 활성을 갖는다.

일 구현예에서, GLP-1R 효능제 펩티드는 천연 GLP-1(7-36)의 GLP-1R 효능제 활성과 비교하여 적어도 약 10배 감소된 GLP-1R 효능제 활성을 갖는다.

일 구현예에서, GLP-1R 효능제 펩티드는 천연 GLP-1(7-36)의 GLP-1R 효능제 활성과 비교하여 최대 약 482.4배 또는 최대 약 482.35배 감소된 GLP-1R 효능제 활성을 갖는다.

일 구현예에서, GLP-1R 효능제 펩티드는 천연 GLP-1(7-36)의 GLP-1R 효능제 활성과 비교하여 최대 약 482배 감소된 GLP-1R 효능제 활성을 갖는다.

일 구현예에서, GLP-1R 효능제 펩티드는 천연 GLP-1(7-36)의 GLP-1R 효능제 활성과 비교하여 약 10배 내지 약 482배 감소된 GLP-1R 효능제 활성을 갖는다.

일 구현예에서, GLP-1R 효능제 펩티드는 천연 GLP-1(7-36)의 GLP-1R 효능제 활성과 비교하여 약 10배 내지 약 319배 감소된 GLP-1R 효능제 활성을 갖는다.

일 구현예에서, GLP-1R 효능제 펩티드는 천연 GLP-1(7-36)의 GLP-1R 효능제 활성과 비교하여 약 90 내지 약 100배 감소된 GLP-1R 효능제 활성을 갖는다.

일 구현예에서, GLP-1R 효능제 펩티드는 천연 GLP-1(7-36)의 GLP-1R 효능제 활성과 비교하여 적어도 약 18배(또는 적어도 약 18.268배) 감소된 GLP-1R 효능제 활성을 갖는다.

일 구현예에서, GLP-1R 효능제 펩티드는 천연 GLP-1(7-36)의 GLP-1R 효능제 활성과 비교하여 약 18배 내지 약 501배(또는 약 18.268배 내지 약 500.686배) 또는 약 18배 내지 약 469배(또는 약 18.268배 내지 약 468.679배) 또는 약 18배 내지 약 313배(또는 약 18.268배 내지 약 313.214배) 또는 약 18배 내지 약 123배(또는 약 18.268배 내지 약 123.466배) 감소된 GLP-1R 효능제 활성을 갖는다.

일 구현예에서, GLP-1R 효능제 펩티드는 천연 GLP-1(7-36)의 GLP-1R 효능제 활성과 비교하여 약 18배 내지 약 313배 감소된 GLP-1R 효능제 활성을 갖는다.

상기 구현예 중 하나에서, GLP-1R 효능제 펩티드는 천연 GLP-1(7-36)의 GLP-1R 효능제 활성과 비교하여 적어도 약 18.2배 또는 적어도 약 18.3배 감소된 GLP-1R 효능제 활성을 갖는다.

상기 구현예 중 하나에서, GLP-1R 효능제 펩티드는 천연 GLP-1(7-36)의 GLP-1R 효능제 활성과 비교하여 적어도 약 20배 또는 적어도 약 50배 또는 적어도 약 100배 감소된 GLP-1R 효능제 활성을 갖는다.

일 구현예에서, GLP-1R 효능제 펩티드는 천연 GLP-1(7-36)의 GLP-1R 효능제 활성과 비교하여 약 10배 내지 약 500배 감소된 GLP-1R 효능제 활성을 갖는다. 일 구현예에서, GLP-1R 효능제 펩티드는 천연 GLP-1(7-36)의 GLP-1R 효능제 활성과 비교하여 약 15배 내지 약 500배 감소된 GLP-1R 효능제 활성을 갖는다. 일 구현예에서, GLP-1R 효능제 펩티드는 천연 GLP-1(7-36)의 GLP-1R 효능제 활성과 비교하여 약 20배 내지 약 500배 감소된 GLP-1R 효능제 활성을 갖는다. 일 구현예에서, GLP-1R 효능제 펩티드는 천연 GLP-1(7-36)의 GLP-1R 효능제 활성과 비교하여 약 50배 내지 약 500배 감소된 GLP-1R 효능제 활성을 갖는다. 일 구현예에서, GLP-1R 효능제 펩티드는 천연 GLP-1(7-36)의 GLP-1R 효능제 활성과 비교하여 약 100배 내지 약 500배 감소된 GLP-1R 효능제 활성을 갖는다. 일 구현예에서, GLP-1R 효능제 펩티드는 천연 GLP-1(7-36)의 GLP-1R 효능제 활성과 비교하여 약 100배 내지 약 300배 감소된 GLP-1R 효능제 활성을 갖는다.

일 구현예에서, 융합 분자의 일부로서의 GLP-1R 효능제 펩티드는, 예를 들어, 인간 GLP-1R을 안정적으로 발현하는 세포의 cAMP 반응을 측정하여 결정시, 약 15 pmol/L 내지 약 400 pmol/L, 또는 약 20 pmol/L 내지 약 400 pmol/L, 또는 약 50 pmol/L 내지 약 400 pmol/L, 또는 약 100 pmol/L 내지 약 400 pmol/L의 EC50으로 인간 GLP-1R을 활성화시킨다. 일 구현예에서, 인간 GLP-1R의 활성화는 본질적으로 실시예 4에 기재된 바와 같이 결정된다.

일 구현예에서, 분리된 형태의 GLP-1R 효능제 펩티드는, 예를 들어, 인간 GLP-1R을 안정적으로 발현하는 세포의 cAMP 반응을 측정하여 결정시, 약 7.5 pmol/L 내지 약 250 pmol/L, 또는 약 7.5 pmol/L 내지 약 150 pmol/L, 또는 약 7.5 pmol/L 내지 약 100 pmol/L, 또는 약 7.5 pmol/L 내지 약 75 pmol/L, 또는 약 8 pmol/L 내지 약 75 pmol/L, 또는 약 9 pmol/L 내지 약 75 pmol/L, 또는 약 9 내지 약 60 pmol/L의 EC50으로 인간 GLP-1R을 활성화시킨다. 일 구현예에서, 인간 GLP-1R의 활성화는 본질적으로 실시예 4에 기재된 바와 같이 결정된다.

일 구현예에서, GLP-1R 효능제 펩티드는 서열번호: 261 내지 552 및 554 내지 565를 포함하거나 이들로 이루어진 그룹으로부터 선택되는 아미노산 서열을 포함하거나 또는 이들로 이루어진다.

일 구현예에서, GLP-1R 효능제 펩티드는 서열번호: 261 또는 262의 아미노산 서열을 포함하거나 또는 이들로 이루어진다.

일 구현예에서, GLP-1R 효능제 펩티드는 서열번호: 553 및 622 내지 634 중 어느 하나의 아미노산 서열을 포함하거나 또는 이들로 이루어지지 않는다.

또 다른 양태에서, 본 발명은 서열번호: 261 내지 552 및 554 내지 565로 이루어진 군으로부터 선택되는 아미노산 서열을 포함하거나 또는 이들로 이루어진 GLP-1R 효능제 펩티드에 관한 것이다.

또 다른 양태에서, 본 발명은 서열번호: 261의 아미노산 서열을 포함하거나 또는 이들로 이루어지거나 서열번호: 262의 아미노산 서열을 포함하거나 또는 이들로 이루어진 GLP-1R 효능제 펩티드에 관한 것이다.

또 다른 양태에서, 본 발명은 상기 정의된 바와 같은 GLP-1R 효능제 펩티드 및 적어도 하나의 다른 활성 약제학적 성분을 포함하는 조합물에 관한 것이다.

또 다른 양태에서, 본 발명은 상기 정의된 바와 같은 GLP-1R 효능제 펩티드 및 적어도 하나의 다른 활성 약제학적 성분을 포함하는 융합 분자에 관한 것이다.

일 구현예에서, 적어도 하나의 다른 활성 약제학적 성분은 FGF21 화합물이다.

또 다른 양태에서, 본 발명은 상기 정의된 바와 같은 GLP-1R 효능제 펩티드 또는 상기 정의된 융합 분자를 인코딩하는 핵산 분자에 관한 것이다.

또 다른 양태에서, 본 발명은 상기 정의된 바와 같은 핵산 분자를 함유하는 숙주 세포에 관한 것이다.

또 다른 양태에서, 본 발명은 상기 정의된 바와 같은 GLP-1R 효능제 펩티드, 상기 정의된 바와 같은 조합물, 상기 정의된 바와 같은 융합 분자, 상기 정의된 바와 같은 핵산 분자 또는 상기 정의된 바와 같은 숙주 세포를 포함하는 약제학적 조성물에 관한 것이다.

또 다른 양태에서, 본 발명은 상기 정의된 바와 같은 GLP-1R 효능제 펩티드, 상기 정의된 바와 같은 조합물, 상기 정의된 바와 같은 융합 분자, 상기 정의된 바와 같은 핵산 분자, 상기 정의된 바와 같은 숙주 세포 또는 상기 정의된 바와 같은 약제학적 조성물을 포함하는 키트에 관한 것이다.

또 다른 양태에서, 본 발명은 제약으로 사용하기 위한, 상기 정의된 바와 같은 GLP-1R 효능제 펩티드, 상기 정의된 바와 같은 조합물, 상기 정의된 바와 같은 융합 분자, 상기 정의된 바와 같은 핵산 분자, 상기 정의된 바와 같은 숙주 세포 또는 상기 정의된 바와 같은 약제학적 조성물에 관한 것이다.

또 다른 양태에서, 본 발명은 비만, 과체중, 대사 증후군, 진성 당뇨병, 고혈당증, 이상지질혈증, NASH 및 죽상동맥경화증으로 이루어진 군으로부터 선택되는 질환 또는 장애의 치료에 사용하기 위한, 상기 정의된 바와 같은 GLP-1R 효능제 펩티드, 상기 정의된 바와 같은 조합물, 상기 정의된 바와 같은 융합 분자, 상기 정의된 바와 같은 핵산 분자 또는 상기 정의된 바와 같은 숙주 세포 또는 상기 정의된 바와 같은 약제학적 조성물에 관한 것이다.

일 구현예에서, 질환 또는 장애는 진성 당뇨병이다. 일 구현예에서, 진성 당뇨병은 1형 진성 당뇨병 또는 2형 진성 당뇨병이다.

또 다른 양태에서, 본 발명은 비만, 과체중, 대사 증후군, 진성 당뇨병, 당뇨병성 망막병증, 고혈당증, 이상지질혈증, NASH 및 죽상동맥경화증으로 이루어진 군으로부터 선택되는 질환 또는 장애의 치료를 위한 약제의 제조에 있어서, 상기 정의된 바와 같은 GLP-1R 효능제 펩티드, 상기 정의된 바와 같은 조합물, 상기 정의된 바와 같은 융합 분자, 상기 정의된 바와 같은 핵산 분자, 상기 정의된 바와 같은 숙주 세포 또는 상기 정의된 바와 같은 약제학적 조성물의 용도에 관한 것이다.

또 다른 양태에서, 본 발명은 비만, 과체중, 대사 증후군, 진성 당뇨병, 당뇨병성 망막병증, 고혈당증, 이상지질혈증, NASH 및 죽상동맥경화증으로 이루어진 군으로부터 선택되는 질환 또는 장애를 치료하는 방법에 관한 것이며, 상기 방법은 상기 정의된 바와 같은 GLP-1R 효능제 펩티드, 상기 정의된 바와 같은 조합물, 상기 정의된 바와 같은 융합 분자, 상기 정의된 바와 같은 핵산 분자, 상기 정의된 바와 같은 숙주 세포 또는 상기 정의된 바와 같은 약제학적 조성물을 이를 필요로 하는 대상체에게 투여하는 단계를 포함한다.

도 1은 GLP-1 감쇠 지수(attenuation factor)에 따른 부작용(위배출률( Gastric Emptying(GE) rate)) 및 약력학(즉, HbA1c, 트리글리세리드, 지방산, 비-HDL, 지방량(Adipose Mass))의 EC50을 나타내는 그래프이다(12개월 시뮬레이션):
● 9.449(약 9로 반올림될 수 있음)보다 큰 GLP-1 감쇠 지수의 경우, GLP-1-매개된 위장관 부작용(위 배출; GE-률)의 EC50은 약력학 효과의 EC50보다 컸으며(즉, HbA1c, 지방량, 비-HDL, 지방산, 트리글리세리드);
● FGF21-(지질) 및 GLP-1-매개된 효과(HbA1c)의 확산에 의해 정규화된 약력학 효과(HbA1c)의 최대치와 부작용(GE률) 사이의 최대 거리는 121.189였으며; 즉 121.189(약 121로 반올림될 수 있음)에서, GLP-1-매개된 효과(HbA1c)와 평균 FGF21-매개된 효과(즉, 지방량, 비-HDL, 지방산, 트리글리세리드) 사이의 최소 거리에서 약력학 효과(HbA1c)의 최대치와 부작용(GE률) 사이의 최대 거리가 있으며(도 2 참조);
● 약력학 효과(HbA1c)의 최대치와 부작용(GE률) 사이의 최대 거리는 319.311(약 319로 반올림될 수 있음)였으며;
● 평균 약력학 효과(즉, HbA1c, 지방량, 비-HDL, 지방산, 트리글리세리드)와 부작용(GE률) 사이의 최대 거리는 482.396(도 2 참조; 약 482로 반올림될 수 있음)였으며;
● 위 배출률의 최대치는 531.0이었다;
(모두: 수직선)
도 2는 GLP-1 감쇠 지수에 따른 GE률 및 평균 약력학 효과(즉, HbA1c, 트리글리세리드, 지방산, 비-HDL, 지방량)의 EC50을 나타내는 그래프이다(12개월 시뮬레이션):
● 평균 약력학(즉, HbA1c, 지방량, 비-HDL, 지방산, 트리글리세리드)과 부작용(GE-률) 사이의 최대 거리는 482.396(오른쪽 수직선; 약 482로 반올림될 수 있음)였으며;
● FGF21-(지질) 및 GLP-1-매개된 효과(HbA1c)의 확산으로 정규화된 약력학 효과(HbA1c)의 최대치와 부작용(GE률) 사이의 최대 거리는 121.189(왼쪽 수직선; 약 121로 반올림될 수 있음)였다. 곡선 "(최대-GE률)/범위"는 HbA1c와 GE률 사이의 최대 거리 및 HbA1c와 평균 FGF21-매개된 효과(즉, 지방량, 비-HDL, 지방산, 트리글리세리드) 사이의 최소 거리 사이의 비율을 나타낸다. "(Max-GE률)/범위" 곡선의 최소치(즉 121.189)에서, GLP-1-매개된 효과(HbA1c)와 FGF21-매개된 효과(즉, 지방량, 비-HDL, 지방산, 트리글리세리드) 사이의 최소 거리에서 약력학 효과(HbA1c)의 최대치와 부작용(GE률) 사이의 최대 거리가 있다.
도 3은 GLP-1 감쇠 지수에 따른 부작용(GE률) 및 약력학(HbA1c, 트리글리세리드, 지방산, 비-HDL, 지방량)의 EC50을 나타내는 그래프이다(3개월 시뮬레이션):
● 18.268(약 18로 반올림될 수 있음)보다 큰 GLP-1 감쇠 지수의 경우, GLP-1-매개된 위장 부작용(위 배출; GE-률)의 EC50이 약력학 효과(즉, HbA1c, 지방량, 비-HDL, 지방산, 트리글리세리드)의 EC50보다 컸으며;
● FGF21-(지질) 및 GLP-1-매개된 효과(HbA1c)의 확산에 의해 정규화된 약력학 효과(HbA1c)의 최대치와 부작용(GE률) 사이의 최대 거리는 123.466이었으며; 즉, 123.466(약 123으로 반올림될 수 있음)에서, GLP-1-매개된 효과(HbA1c)와 평균 FGF21-매개된 효과(즉, 지방량, 비-HDL, 지방산, 트리글리세리드) 사이의 최소 거리에 약력학 효과(HbA1c)의 최대치와 부작용(GE률) 사이의 최대 거리가 있으며(도 4 참조);
● 약력학 효과(HbA1c)의 최대치와 부작용(GE-률) 사이의 최대 거리는 313.214(약 313으로 반올림될 수 있음)였으며;
● 평균 약력학 효과(즉, HbA1c, 지방량, 비-HDL, 지방산, 트리글리세리드)와 부작용(GE-률)사이의 최대 거리는 468.679(도 4 참조; 약 469로 반올림될 수 있음)였으며;
● GE률의 최대치는 500.686(약 501로 반올림될 수 있음)이었다(모두: 수직선).
도 4는 GLP-1 감쇠 지수에 따른 GE률 및 평균 약력학 효과(즉, HbA1c, 트리글리세리드, 지방산, 비-HDL, 지방량)의 EC50을 나타내는 그래프이며(3개월 시뮬레이션):
● 평균 약력학 효과(즉, HbA1c, 지방량, 비-HDL, 지방산, 트리글리세리드)와 부작용(GE-률) 사이의 최대 거리는 468.679(오른쪽 수직선; 약 469로 반올림될 수 있음)였으며;
● FGF21-(지질) 및 GLP-1-매개된 효과(HbA1c)의 확산에 의해 정규화된 약력학 효과(HbA1c)의 최대치와 부작용(GE률) 사이의 최대 거리는 123.466(왼쪽 수직선; 약 123으로 반올림될 수 있음)이었다. 곡선 "(Max-GE률)/범위"는 HbA1c와 GE률 사이의 최대 거리 및 HbA1c와 평균 FGF21-매개된 효과(즉, 지방량, 비-HDL, 지방산, 트리글리세리드) 사이의 최소 거리 사이의 비율을 나타낸다. "(Max-GE률)/범위" 곡선의 최소치에서(즉 123.466에서), GLP-1-매개된 효과(HbA1c)와 FGF21-매개된 효과(즉, 지방량, 비-HDL, 지방산, 트리글리세리드) 사이의 최소 거리에 약력학 효과(HbA1c)의 최대치와 부작용(GE률) 사이의 최대 거리가 있다.
도 5(A 및 B)는 CHO 세포에서 인간 FGF21 수용체 효능에 대한 시험관내(in vitro) 세포 분석(In-Cell Western(ICW))의 결과를 나타내는 그래프이다. pFGFR은 (A)에 표시되어 있고, pERK는 (B)에 표시된다.
도 6(A 내지 D)은 상이한 GLP-1R 효능제에 대한 HEK-293 세포에서의 인간 글루카곤-유사-펩티드 1(GLP-1) 수용체 효능에 대한 시험관내 세포 분석 결과를 나타내는 그래프이다. (A)에 서열번호: 2가 표시되어 있고, (B)에 서열번호: 7이 표시되어 있고, (C)에 서열번호: 8이 표시되어 있고, (D)에는 서열번호: 2, 7 및 8이 표시되어 있다.
도 7(A 내지 F)은 3개의 상이한 생체분석 방법을 사용하여 암컷 C57Bl/6 마우스 또는 수컷 사이노몰구스 원숭이에게 0.3 mg/kg 용액의 단일 피하 투여 후 GLP-1R 효능제/FGF21 Fc 융합 단백질의 혈장 농도를 나타내는 그래프이다. (A)는 마우스에서의 서열번호: 2를 표시하고, (B)는 원숭이에서의 서열번호: 2를 표시하고, (C)는 마우스에서의 서열번호: 7을 표시하고, (D)는 원숭이에서의 서열번호: 7을 표시하고, (E)는 마우스에서의 서열번호: 8을 표시하고, (F)는 원숭이에서의 서열번호: 8을 표시한다.
도 8은 온전한 전체 길이 단백질의 정량화를 위한 생체분석 방법을 사용하여 암컷 C57Bl/6 마우스에게 0.3 mg/kg 용액을 단일 피하 투여한 후 GLP-1R 효능제/FGF21 Fc 융합 단백질 및 G-FGF21(서열번호: 252)의 혈장 농도를 나타내는 그래프이다.
도 9는 28일 동안 GLP-1RA/FGF21 Fc 융합 단백질 및 대조군을 매주 1회 투여한 암컷 식이-유발 비만(DIO) 마우스의 체중 발달을 나타내는 그래프이다.
도 10은 28일 동안 GLP-1RA/FGF21 Fc 융합 단백질 및 대조군을 매주 1회 투여한 암컷 DIO 마우스에서의 누적 음식 섭취량의 전개상황을 나타내는 그래프이다.
도 11(A 및 B)은 (A) GLP-1RA/FGF21 Fc 융합 단백질 및 대조군으로 1일째에 시작하는 1차 처리 후 또는 (B) 22일째에 시작하는 4차 처리 후의 db/db 마우스의 24시간 혈당 프로파일을 나타내는 그래프이다. 데이터는 평균 ± SEM이고; n=8/그룹.
도 12는 36일 동안 GLP-1RA/FGF21 Fc 융합 단백질 및 대조군을 매주 1회 투여한 암컷 db/db 마우스의 혈장 HbA1c 함량을 나타내는 그래프이다.
도 13(A 및 B)은 8주 동안 GLP-1RA/FGF21 Fc 융합 단백질 및 대조군을 매주 1회 투여한 후 DIO NASH 마우스에서 간 중량 및 지질 함량의 전개상황을 나타내는 그래프이다. (A)는 간 중량 및 지질 수준을 표시하고, (B)는 간 콜레스테롤 및 간 트리글리세리드 수준을 표시한다.
도 14는 8주 동안 GLP-1RA/FGF21 Fc 융합 단백질 및 대조군을 매주 1회 투여한 후 DIO NASH 마우스에서 섬유증 및 비알코올성 지방간 질환(NAFLD) 활성 점수의 발달을 나타내는 그래프이다.
도 15는 8주 동안 GLP-1RA/FGF21 Fc 융합 단백질 및 대조군을 매주 1회 투여한 후 DIO NASH 마우스에서 섬유증 및 NAFLD 활성 점수가 높거나 같거나 낮은 동물의 수를 나타내는 그래프이다.

본 발명은 하기에 상세히 기재되어 있지만, 본 명세서에 기재된 특정 방법, 프로토콜 및 시약이 달라질 수 있기 때문에, 본 발명이 이들에 제한되지 않음이 이해되어야 한다. 또한, 본 명세서에서 사용되는 용어는 특정 구현예를 기재하기 위한 목적만을 위한 것이며, 본 발명의 범주를 제한하고자 하는 것이 아니고, 본 발명의 범주는 첨부된 청구범위에 의해서만 제한될 것임이 이해되어야 한다. 달리 정의되지 않는 한, 본 명세서에서 사용되는 모든 기술 및 과학 용어는 당업자가 일반적으로 이해하는 것과 동일한 의미를 갖는다.

본 명세서에서 본 발명의 특정 요소가 보다 상세히 기재될 것이다. 이러한 요소들은 특별한 특정 구현예들과 함께 열거될 수 있지만, 이들은 임의의 방식으로, 그리고 임의의 수로 조합되어서 추가의 구현예들을 생성할 수 있음이 이해되어야 한다. 다양하게 기재된 실시예 및 예시적인 구현예는 본 발명을 단지 명백하게 기재된 구현예에 한정시키는 것으로 해석되서는 안된다. 이 상세한 설명은 명백하게 기재된 구현예들을 임의의 수의 개시된 및/또는 예시적인 요소들과 조합시킨 구현예들을 뒷받침하고 포함하는 것으로 이해되어야 한다. 더욱이, 본 출원에서 모든 기재된 요소들의 임의의 순열 및 조합은 맥락이 달리 표시하지 않는 한 본 출원의 설명에 의해 개시되는 것으로 간주되어야 한다.

본 명세서에서 사용되는 용어는 문헌["A multilingual glossary of biotechnological terms: (IUPAC Recommendations)", H.G.W. Leuenberger, B. Nagel, and H. Koelbl, Eds, Helvetica Chimica Acta, CH-4010 Basel, Switzerland, (1995)]에 기재된 바와 같이 정의된다.

본 발명의 실시에서는, 달리 표시되지 않는 한, 본 분야의 문헌[Sambrook, J. et al. (2001) Molecular Cloning: A Laboratory Manual, 3rd Ed, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY]에 설명된, 화학, 생화학, 세포 생물학, 면역학의 통상적인 방법, 및 재조합 DNA 기법이 이용될 것이다.

맥락상 달리 필요하지 않다면, 본 명세서 및 하기의 청구범위 전체에 걸쳐 용어 "포함하다(comprise)" 및 변이형, 예컨대 "포함한다(comprises)" 및 "포함하는(comprising)"은 언급된 구성원, 정수 또는 단계, 또는 구성원, 정수 또는 단계의 군의 포함을 암시하며, 일부 구현예에서 임의의 다른 구성원, 정수 또는 단계, 또는 구성원, 정수 또는 단계의 군이 배제될 수도 있지만 그러한 다른 구성원, 정수 또는 단계, 또는 구성원, 정수 또는 단계의 군의 배제를 암시하는 것은 아니라는 점, 즉, 주제는 언급된 구성원, 정수 또는 단계, 또는 구성원, 정수 또는 단계의 군을 포함하는 것으로 이루어짐이 이해될 것이다. 본 발명을 기재하는 맥락에서(특히, 하기 청구범위의 맥락에서) 사용된 단수형("a" 및 "an" 및 "the" 등) 용어 등은 본 명세서에서 달리 표시되지 않거나 맥락에 의해 명확하게 반박되지 않는 한, 단수형 및 복수형 둘 다를 포함하는 것으로 해석되어야 한다. 본 명세서에서 값들의 범위들의 나열은 그 범위 내에 있는 각각의 별개의 값을 개별적으로 나타내는 대신 간략하게 표기하는 역할을 하고자 한다. 본 명세서에서 달리 표시되지 않는 한, 각각의 개별 값은 마치 이것이 본 명세서에 개별적으로 나열되는 것처럼 본 명세서 내에 포함된다. 본 명세서에 기재된 모든 방법은, 본 명세서에서 달리 표시되지 않거나 맥락에 의해 달리 명확하게 반박되지 않는 한 임의의 적합한 순서로 수행될 수 있다. 본 명세서에 제공된, 임의의 모든 예, 또는 예시적인 언어(예를 들어, "~와 같은(such as)")의 사용은 단지 본 발명을 더 잘 예시하고자 하는 것이며, 달리 청구된 본 발명의 범주에 대한 제한을 제기하는 것이 아니다. 본 명세서에서의 언어는 본 발명의 실행에 필수적인 임의의 청구되지 않은 요소를 나타내는 것으로 해석되어서는 안 된다.

몇몇 문서는 본 명세서의 본문 전체에 걸쳐 인용된다. 각각의 본 명세서에 인용된 문서(모든 특허, 특허 출원, 과학 간행물, 제조업자의 사양, 지침 등을 포함함)는, 상기 문헌(supra)이든지, 하기 문헌(infra)이든지 간에, 그 전체가 본 명세서에 참고로 포함된다. 본 명세서에서 어느것도, 종래 발명에 의한 상기 개시 내용보다 본 발명이 선행할 자격이 없음을 인정하는 것으로 해석되어서는 안 된다.

본 명세서에서 사용되는 용어 "GLP-1R 효능제 펩티드(GLP-1R agonistic peptide)"는 GLP-1(1차 GLP-1R 효능제로서)과 같은 GLP-1 수용체에 결합하고 이를 활성화시키는 펩티드를 지칭한다. GLP-1R 효능제 펩티드는 또한 본 명세서에서 간단히 "GLP-1R 효능제(GLP-1R agonists)"로 지칭될 수 있다.

본 명세서에서 사용되는 용어 "펩티드(peptide)"는 일반적으로, 예를 들어, 펩티드 결합에 의해 공유 결합된 약 2개 이상, 또는 약 3개 이상, 또는 약 4개 이상, 또는 약 6개 이상, 또는 약 8개 이상, 또는 약 9개 이상, 또는 약 10개 이상, 또는 약 13개 이상, 또는 약 16개 이상, 또는 약 21개 이상의 아미노산을 포함하는, 임의의 길이의 아미노산의 중합체 형태를 지칭한다. 예를 들어, 펩티드는 최대 약 100개의 아미노산으로 이루어질 수 있다. 본 명세서에서 사용되는 용어 "폴리펩티드(polypeptide)"는 거대 펩티드를 지칭한다. 일 구현예에서, 용어 "폴리펩티드"는 약 100개 초과의 아미노산 잔기를 갖는 펩티드를 지칭한다. 용어 "폴리펩티드" 및 "단백질"은 본 명세서에서 상호교환적으로 사용된다.

본 명세서에서 사용되는 용어 "아미노산(amino acid)" 또는 "아미노산 잔기(amino acid residue)"는, 구조가 입체이성질체 형태를 허용하는 경우 D 또는 L 입체이성질체로 천연-생성(naturally-occurring) 아미노산, 비천연 아미노산, 아미노산 유사체 및/또는 천연-생성 아미노산과 유사한 방식으로 작용하는 아미노산 모방체를 지칭한다. 아미노산은 여기에서 그들의 이름, 당업계에 알려진 3문자 기호 또는 IUPAC-IUB 생화학 명명법 위원회에서 권장하는 1문자 기호로 지칭된다.

본 명세서에서 사용되는 "천연 생성(naturally occurring)"이라는 용어는 핵산 분자, (폴리)펩티드, 숙주 세포 등과 같은 생물학적 물질과 관련하여 사용될 때, 천연에서 발견되고 인간에 의해 조작되지 않은 물질을 지칭한다.

아미노산과 관련하여 사용될 때, 용어 "천연 생성"은 20가지의 통상적인 아미노산(즉, 알라닌(Ala 또는 A), 시스테인(Cys 또는 C), 아스파르트산(Asp 또는 D), 글루탐산(Glu 또는 E), 페닐알라닌(Phe 또는 F), 글리신(Gly 또는 G), 히스티딘(His 또는 H), 이소류신(Ile 또는 I), 라이신(Lys 또는 K), 류신(Leu 또는 L), 메티오닌(Met 또는 M), 아스파라긴(Asn 또는 N), 프롤린(Pro 또는 P), 글루타민(Gln 또는 Q), 아르기닌(Arg 또는 R), 세린(Ser 또는 S), 트레오닌(Thr 또는 T), 발린(Val 또는 V), 트립토판(Trp 또는 W), 및 티로신(Tyr 또는 Y))뿐만 아니라, 셀레노시스테인, 피롤라이신(PYL), 및 피롤린-카르복시라이신(PCL)을 나타낸다.

본 명세서에서 사용되는, 용어 "비천연 아미노산(unnatural amino acid)"은 임의의 유기체의 유전자 코드에서 천연적으로 인코딩되지 않거나 발견되지 않는 아미노산을 지칭하는 것이다. 이것은, 예를 들어, 순전히 합성인 화합물일 수 있다. 비천연 아미노산의 예는 히드록시프롤린, 감마-카르복시글루타메이트, O-포스포세린, 아제티딘카르복실산, 2-아미노아디프산, 3-아미노아디프산, 베타-알라닌, 아미노프로피온산, 2-아미노부티르산, 4-아미노부티르산, 6-아미노카프로익산, 2-아미노헵탄산, 2-아미노이소부티르산, 3-아미노이소부티르산, 2-아미노피멜산, 3차-부틸글리신, 2,4-디아미노이소부티르산, 데스모신, 2,2'-디아미노피멜산, 2,3-디아미노프로피온산, N-에틸글리신, N-메틸글리신, N-에틸아스파라긴, 호모프롤린, 히드록시라이신, 알로-히드록시라이신, 3-히드록시프롤린, 4-히드록시프롤린, 이소데스모신, 알로-이소류신, N-메틸알라닌, N-메틸글리신, N-메틸이소류신, N-메틸펜틸글리신, N-메틸발린, 나프탈라닌, 노르발린, 노르류신, 오르니틴, D-오르니틴, D-아르기닌, p-아미노페닐알라닌, 펜틸글리신, 피페콜산 및 티오프롤린을 포함하지만, 이에 제한되는 것은 아니다.

본 명세서에서 사용되는, 용어 "아미노산 유사체(amino acid analogue)"는 천연 생성 아미노산과 동일한 기본 화학 구조를 갖는 화합물을 나타낸다. 아미노산 유사체는, 가역적으로 또는 비가역적으로, 예를 들어, C-말단 카르복시 기, N-말단 아미노 기 및/또는 측쇄 기능성 기 중 어느 하나 또는 이들의 임의의 조합에서 화학적으로 차단되거나 또는 화학적으로 변형된 천연 및 비천연 아미노산을 포함한다. 그러한 유사체는 메티오닌 술폭시드, 메티오닌 술폰, S-(카르복시메틸)-시스테인, S-(카르복시메틸)-시스테인 술폭시드, S-(카르복시메틸)-시스테인 술폰, 아스파르트산-(베타메틸에스테르), N-에틸글리신, 알라닌 카르복스아미드, 호모세린, 노르류신 및 메티오닌 메틸 술포늄을 포함하지만, 이에 제한되는 것은 아니다.

본 명세서에서 사용되는, 용어 "아미노산 모방체(amino acid mimetic)"는 아미노산의 일반 화학 구조와는 상이하지만 천연 생성 아미노산과 유사한 방식으로 기능하는 구조를 갖는 화합물을 나타낸다.

본 명세서에서 사용되는, 용어 "천연 GLP-1(7-36)"은 서열번호: 260의 아미노산 서열을 갖는 펩티드를 지칭하며, 이는 선택적으로 이의 C-말단에 아미드기를 포함한다.

일 구현예에서, 본 명세서에서 사용되는, 용어 "GLP-1R 효능제 활성(GLP-1R agonistic activity)"(또는 "GLP-1R 효능제 효능(GLP-1R agonistic potency)")은 GLP-1 수용체의 활성화를 나타낸다. 일 구현예에서, 이 용어는 시험관내(in vitro) 효능제 활성/효능을 나타낸다. 또 다른 구현예에서, 이 용어는 생체내(in vivo) 효능제 활성/효능을 나타낸다. 일 구현예에서, GLP-1 수용체의 활성화는 시험관내에서 효능제와의 접촉시 GLP-1 수용체를 안정적으로 발현하는 세포의 cAMP 반응을 측정함으로써 결정된다. 일 구현예에서, 세포는 HEK-293 세포주로부터의 세포이다. 일 구현예에서, GLP-1 수용체는 인간 GLP-1 수용체이다. 일 구현예에서, GLP-1 수용체의 활성화는 본질적으로 실시예 4에 기재된 바와 같이 결정된다. 일 구현예에서, 활성/효능은 EC50 값을 측정함으로써 정량화된다.

본 발명은 본 명세서에 정의된 바와 같은 서열번호: 635 및 636의 일반식에 따른 GLP-1R 효능제 펩티드를 제공한다.

일부 구현예에서, 서열번호: 635 및 636의 일반식에 따른 GLP-1R 효능제 펩티드는 이들의 N-말단에 적어도 하나의 추가적인 아미노산 잔기를 포함한다. 일 구현예에서, 적어도 하나의 추가 아미노산 잔기는 단일 아미노산 잔기이다. 일 구현예에서, 적어도 하나의 추가 아미노산 잔기는 프롤린을 제외한 천연 생성 아미노산; 비천연 아미노산; 아미노산 유사체; 및 아미노산 모방체로 이루어진 군으로부터 선택된다. 일 구현예에서, 적어도 하나의 추가 아미노산 잔기는 G, A, N 및 C로 이루어진 군으로부터 선택된다. 일 구현예에서, 적어도 하나의 추가 아미노산 잔기는 G 또는 A이다. 일 구현예에서, 적어도 하나의 추가 아미노산 잔기는 G이다.

일부 구현예에서, 서열번호: 635 및 636의 일반식에 따른 GLP-1R 효능제 펩티드는 이들의 C-말단에 펩티드 연장부를 포함한다. 펩티드 연장부는, 예를 들어, 최대 약 12개, 약 11개, 약 10개 또는 약 9개의 아미노산 잔기(예를 들어, 약 7개, 약 8개 또는 약 9개의 아미노산 잔기)로 이루어질 수 있다. 일 구현예에서, 펩티드 연장부는 서열번호: 566 내지 621로 이루어진 군으로부터 선택되는 아미노산 서열로 이루어진다. 일 구현예에서, 펩티드 연장부는 단일 아미노산 잔기, 예를 들어 P이다.

본 발명은 또한 서열번호: 261 내지 552 및 554 내지 565로 이루어진 군으로부터 선택되는 아미노산 서열뿐만 아니라, 1개, 2개 또는 3개의 아미노산 잔기의 치환으로 원래 서열과 상이한 이들 아미노산 서열의 변이체를 포함하거나 또는 이들로 이루어진 GLP-1R 효능제 펩티드를 제공한다.

본 발명은 또한 서열번호: 261 또는 서열번호: 262인 아미노산 서열뿐만 아니라 1개, 2개 또는 3개의 아미노산 잔기의 치환으로 원래 서열과 상이한 이들 아미노산 서열의 변이체를 포함하거나 또는 이들로 이루어진 GLP-1R 효능제 펩티드를 제공한다.

일 구현예에서, 치환된 아미노산 잔기(들)는 GLP-1R 효능제 펩티드의 GLP-1R 효능제 활성에 관여하지 않는다. 일 구현예에서, 치환(들)은 기능적으로 및/또는 표현형적으로 침묵성이다. 일 구현예에서, 치환(들)은 보존적 아미노산 치환(들)이다.

본 명세서에서 사용되는, "보존적 아미노산 치환(conservative amino acid substitution)"이라는 용어는 하나 이상의 아미노산을 동일한 아미노산 패밀리의 하나 이상의 아미노산, 즉 이들의 측쇄에서 관련된 아미노산(예를 들어, 전하 및/또는 크기 면에서)으로의 치환을 지칭한다. 천연 생성 아미노산은 일반적으로 다음 4가지 패밀리로 구분된다: 산성(아스파르테이트, 글루타메이트); 염기성(라이신, 아르기닌, 히스티딘); 비극성(알라닌, 발린, 류신, 이소류신, 프롤린, 페닐알라닌, 메티오닌, 트립토판); 및 하전되지 않은 극성(글리신, 아스파라긴, 글루타민, 시스테인, 세린, 트레오닌, 티로신). 페닐알라닌, 트립토판 및 티로신은 때때로 함께 방향족 아미노산으로 분류된다.

GLP-1R 효능제 펩티드는 반감기 연장 모듈에 융합되거나 컨주게이션될 수 있다. 본 명세서에서 사용되는 "반감기(Half-life)"는 일반적으로 화합물 활성, 화합물의 양, 또는 분자 수의 절반을, 예를 들어, 생체내에서 제거하는 데 필요한 기간을 지칭한다. 이러한 모듈은 당업자에게 공지되어 있고, 예를 들어, 중합체(예를 들어, 폴리에틸렌 글리콜(PEG), 하이드록시에틸 전분(HES), 히알루론산, 폴리시알산), 비구조화 (폴리)펩티드 사슬, 엘라스틴-유사 폴리펩티드(ELP), 혈청 단백질(예를 들어, 인간 혈청 알부민(HAS)과 같은, 알부민), 혈청 단백질 결합 분자(예를 들어, 알부민 결합 도메인(ABD), 알부민 결합 지방산), 항체, 면역글로불린, 면역글로불린의 Fc 도메인(Fc 영역으로도 지칭됨) 및 면역글로불린 결합 도메인을 포함한다.

본 명세서에서 사용되는 "비구조화 (폴리)펩티드 사슬(unstructured (poly-)peptide chain)"이라는 용어는 고정되거나 정렬된 3차원 구조가 결여되어 있고 통상적으로 친수성인 (폴리)펩티드 사슬을 의미한다. 이들이 융합된 펩티드 및 단백질의 반감기(예를 들어, 생체내 반감기)를 연장시키는 비구조화 (폴리)펩티드 사슬은 당업자에게 공지되어 있고, 예를 들어, XTEN(Schellenberger V. et al. (2009) Nat Biotechnol. 27(12): 1186-90) 및 PAS 서열(Schlapschy M. et al. (2013) Protein Eng Des Sel. 26(8): 489-501)을 포함한다.

본 명세서에서 사용되는 용어 "~에 융합된(fused to)"은, 특히, 예를 들어, 재조합 DNA 기술에 의한 유전적 융합을 지칭한다. (폴리)펩티드 반감기 연장 모듈의 아미노산 서열은 GLP-1R 효능제 펩티드의 아미노산 서열 내의 임의의 위치에 도입될 수 있고, 예를 들어, 인코딩된 펩티드 구조 내에서 루프의 형태를 취할 수 있거나, 또는 N-말단 또는 C-말단 융합될 수 있다. GLP-1R 효능제 펩티드에 융합된 (폴리)펩티드 반감기 연장 모듈의 아미노산 서열은 폴리뉴클레오티드에 의해 인코딩될 수 있다.

본 명세서에서 사용되는 용어 "~에 컨주게이션된(conjugated to)"은 (폴리)펩티드와 다른 분자, 예를 들어, GLP-1R 효능제 펩티드 및 반감기 연장 모듈 사이의 안정한 공유 결합을 초래하는 화학적 및/또는 효소적 컨주게이션을 지칭한다. 이러한 컨주게이션은 (폴리)펩티드의 N- 또는 C-말단 또는 특정 측쇄, 예를 들어, 라이신, 시스테인, 티로신 또는 비천연 아미노산 잔기에서 발생할 수 있다.

본 명세서에서 사용되는 용어 "조합(combination)"은, GLP-1R 효능제 펩티드 및 적어도 하나의 다른 활성 약제학적 성분을 환자에게 개별 투여함으로써, 또는 GLP-1R 효능제 펩티드 및 적어도 하나의 다른 활성 약제학적 성분을, 예를 들어, 하나의 약제학적 조성물 또는 융합 분자의 형태로 존재하는, 조합 제품의 형태로 투여함으로써, GLP-1R 효능제 펩티드 및 적어도 하나의 다른 활성 약제학적 성분을 포함하는 조합을 적용할 수 있게 하는 수단을 포함하고자 한다. 개별적으로 투여하는 경우, 투여는 임의의 순서로 동시에 또는 순차적으로 발생할 수 있다. GLP-1R 효능제 펩티드 및 적어도 하나의 다른 활성 약제학적 성분의 양 뿐만 아니라 투여의 상대적 시기는 원하는 조합된 치료 효과를 달성하기 위해 선택될 것이다. 조합의 투여는 (1) 모든 활성 약제학적 성분을 포함하는 단일 약제학적 조성물; 또는 (2) 활성 약제학적 성분 중 적어도 하나를 각각 포함하는 별개의 약제학적 조성물로 동시에 수행될 수 있다. 대안적으로, 조합물은 하나의 치료제가 먼저 투여되고 다른 치료제가 두 번째로 투여되거나 그 반대인 순차적인 방식으로 개별적으로 투여될 수 있다. 이러한 순차적 투여는 가까운 시간에 이루어질 수도 있고 먼 시간에 이루어질 수도 있다. 일 구현예에서, 조합은 키트, 예를 들어, 본 명세서에 정의된 키트의 형태로 제공된다.

본 명세서에서 사용되는 용어 "융합 분자(fusion molecule)"는 일반적으로 2개 이상의 별개의 분자(예를 들어, 단백질 및/또는 펩티드 및/또는 이들의 조합)를 결합, 특히 공유 결합시켜 단일 분자의 형성을 초래하여 생성된 분자를 지칭한다. 특정한 예시적 구현예에서, 융합 분자는 각각의 원래 분자로부터 유래된 하나 이상의 기능적 특성을 가질 것이다. 단백질 및/또는 펩티드의 경우, 융합 분자는 또한 "융합 단백질"이라고도 지칭된다. 융합 분자는 예를 들어 2개 이상의 폴리펩티드, 단백질 또는 이들의 조합의, 유전적 융합(예를 들어, 재조합 DNA 기술)에 의해 또는 화학적 및/또는 효소적 컨주게이션에 의해 생성될 수 있다. 2개 이상의 별개의 분자는 또한 하나 이상의 적합한 링커 분자, 예를 들어, 펩티드 링커 및/또는 PEG와 같은 비펩티드 중합체에 의해 연결될 수 있다.

일 구현예에서, 펩티드 링커는 약 2 내지 약 100개의 아미노산 잔기, 또는 약 2 내지 약 90개의 아미노산 잔기, 또는 약 2 내지 약 80개의 아미노산 잔기, 또는 약 2 내지 약 70개의 아미노산 잔기, 또는 약 2 내지 약 60개의 아미노산 잔기, 또는 약 2 내지 약 50개의 아미노산 잔기, 또는 약 2 내지 약 40개의 아미노산 잔기, 또는 약 2 내지 약 30개의 아미노산 잔기, 또는 약 2 내지 약 25개의 아미노산 잔기, 또는 약 2 내지 약 20개의 아미노산 잔기 길이를 갖는다. 일 구현예에서, 펩티드 링커는 적어도 약 5개의 아미노산 잔기를 포함한다. 일반적으로, 펩티드 링커는 유연성과 프로테아제 저항성을 제공하도록 설계된다. 일 구현예에서, 펩티드 링커는 글리신-세린-풍부 링커이고, 여기서, 예를 들어, 적어도 약 50%, 적어도 약 60%, 적어도 약 70%, 적어도 약 80%, 적어도 약 85%의 아미노산은, 각각, 글리신 또는 세린 잔기이다. 또 다른 구현예에서, 아미노산은 글리신 및 세린으로부터 선택된다. 즉, 펩티드 링커는 글리신 및 세린으로만 구성된다(글리신-세린 링커라고 함). 일 구현예에서, 펩티드 링커는 이의 C-말단에 알라닌 잔기를 추가로 포함한다. 펩티드 링커는 하나 이상의 특정 프로테아제 절단 부위를 추가로 포함할 수 있다. 일 구현예에서, 펩티드 링커는 서열번호: 231 내지 245로 이루어진 군으로부터 선택되는 아미노산 서열을 포함하거나 또는 이들로 이루어진다.

일 구현예에서, 융합 분자는 면역글로불린(예를 들어, IgG1 또는 IgG4) 또는 이의 변이체의 Fc 도메인(Fc 영역이라고도 함)을 추가로 포함한다. 일 구현예에서, Fc 도메인의 변이체는 Fc 도메인의 야생형 서열과 비교하여 최대 약 6개, 약 5개 또는 약 4개의 돌연변이를 포함한다. 일 구현예에서, 상기 돌연변이는 아미노산 치환, 아미노산 부가 및 아미노산 결실, 예를 들어, N- 또는 C-말단 결실로 이루어진 군으로부터 선택된다. 일 구현예에서, Fc 도메인 또는 이의 변이체는 약 50%, 약 60%, 약 70%, 약 80%, 약 90%, 약 93%, 약 95%, 약 96%, 약 97%, 약 98% 또는 약 99% 초과의 서열 동일성을 갖거나 또는 IgG1 Fc 영역, 예를 들어, 인간 IgG1 Fc 영역의 야생형 서열에 대해 약 100% 서열 동일성을 가질 수 있다. 일 구현예에서, Fc 도메인 또는 이의 변이체는 약 50%, 약 60%, 약 70%, 약 80%, 약 90%, 약 93%, 약 95%, 약 96%, 약 97%, 약 98% 또는 약 99% 초과의 서열 동일성을 갖거나 또는 IgG4 Fc 영역, 예를 들어, 인간 IgG4 Fc 영역의 야생형 서열에 대해 약 100% 서열 동일성을 가질 수 있다. 일 구현예에서, 면역글로불린 또는 이의 변이체의 Fc 도메인은 서열번호: 257, 258 및 259로 이루어진 군으로부터 선택되는 아미노산 서열을 포함하거나 또는 이들로 이루어진다.

일 구현예에서, 융합 분자는 L - Fc, Fc - L, L₁ - Fc - L₂및 Fc로 이루어진 군으로부터 선택되는 구조를 포함하는 링커 분자를 포함하며, 여기서 L, L₁ 및 L₂는, 단일 아미노산 및 펩티드(예를 들어, 본 명세서에 정의된 바와 같은 펩티드 링커)로 이루어진 군으로부터 독립적으로 선택되고, Fc는 면역글로불린 또는 이의 변이체의 Fc 도메인이다. L₁과 L₂는 같거나 다를 수 있다. 일 구현예에서, L₁과 L₂는 상이하다. 일 구현예에서, L₁은 서열번호: 232의 아미노산 서열을 포함하거나 또는 이들로 이루어지고, L₂는 서열번호: 231의 아미노산 서열을 포함하거나 또는 이들로 이루어지거나, 또는 그 반대도 가능하다.

본 명세서에서 사용되는 "섬유아세포 성장 인자 21(fibroblast growth factor 21)" 또는 "FGF21"이라는 어구는 당업계에 공지된 임의의 FGF21 단백질을 지칭하고, 특히 인간 FGF21을 지칭한다. 일 구현예에서, 인간 FGF21은 서열번호: 250의 아미노산 서열(전장 인간 야생형 FGF21)을 갖는다. 성숙한 인간 야생형 FGF21, 즉 서열번호: 250의 아미노산 1 내지 28(M1 내지 A28)(즉, 이의 신호 서열/펩티드)이 결여된 인간 야생형 FGF21은 서열번호: 251로 제시되어 있다. 추가적인 N-말단 Gly를 갖는 성숙한 인간 야생형 FGF21은 서열번호: 252로 표시되고 본 명세서에서 G-FGF21로 지칭된다.

본 명세서에서 사용되는 "FGF21 화합물"이라는 어구는 일반적으로 FGF21 활성을 갖는 화합물을 지칭한다.

일 구현예에서, 본 명세서에서 사용되는 "FGF21 활성"(또는 "FGF21 효능")이라는 어구는 FGF21 수용체(FGFR, 예를 들어, FGFR1c)의 활성화를 지칭한다. 일 구현예에서, FGF21 수용체는 인간 FGF21 수용체이다. 일 구현예에서, FGF21 활성은 시험관내(in vitro) 활성 및/또는 효능을 지칭한다. 또 다른 구현예에서, FGF21 활성은 생체내 활성 및/또는 효능을 의미한다. 일 구현예에서, FGF21 수용체의 활성화는 FGF21 수용체 자가인산화 및/또는 시험관내에서(in vitro) FGF21 화합물과 접촉시 MAPK ERK1/2의 인산화를 측정함으로써 결정된다. 일 구현예에서, 인간 FGFR1c의 자가인산화 및/또는 MAPK ERK1/2의 인산화는, 예를 들어, 본질적으로 실시예 3에 기재된 바와 같이 In-Cell Western(ICW)을 사용하여 결정된다. 일 구현예에서, 활성 및/또는 효능은 EC50 값을 결정하여 정량화된다.

본 명세서에서 사용되는 용어 "세포내 웨스턴(ICW; In-Cell Western) 분석"은 면역세포화학적 분석, 보다 구체적으로는 마이크로플레이트(예를 들어, 96- 또는 384-웰 형식)를 사용하여 통상적으로 수행되는 정량적 면역형광 분석을 지칭한다. ICW는 웨스턴 블랏팅의 특이성을 ELISA의 재현성 및 처리량과 결합한다(예를 들어, 문헌[Aguilar H.N. et al. (2010) PLoS ONE 5(4): e9965] 참조). 적절한 ICW 분석 시스템은 상업적으로 이용가능하다(예를 들어, LI-COR Biosciences, USA). 일 구현예에서, 항-pFGFR 항체 및/또는 항-pERK 항체가 ICW 분석에 사용된다.

일 구현예에서, FGF21 화합물은 펩티드 화합물, 즉 펩티드 또는 단백질이다. 일 구현예에서, FGF21 화합물은 천연 FGF21 또는 천연 FGF21의 아미노산 서열에 대해 적어도 약 80% 또는 적어도 약 90% 또는 적어도 약 91% 또는 적어도 약 92% 또는 적어도 약 93% 또는 적어도 약 94% 또는 적어도 약 95% 또는 적어도 약 96% 또는 적어도 약 97% 또는 적어도 약 98% 아미노산 서열 동일성을 갖는 FGF21 변이체이다. 본 명세서에서 사용되는 용어 "천연 FGF21"은 천연 생성 FGF21, 예를 들어, 서열번호: 250의 아미노산 서열을 갖는 인간 야생형 FGF21 또는 서열번호: 251의 아미노산 서열을 갖는 성숙한 인간 야생형 FGF21을 지칭한다.

본 명세서에서 사용되는 "서열 동일성(Sequence identity)"은 2개의 아미노산 또는 핵산 서열 간에 동일한 아미노산의 백분율을 지칭한다. 비교를 위한 서열의 최적 정렬은 문헌[Smith and Waterman, 1981, Ads App. Math. 2, 482]의 로컬 상동성 알고리즘을 통해, 문헌[Neddleman and Wunsch, 1970, J. Mol. Biol. 48, 443]의 로컬 상동성 알고리즘을 통해, 문헌[Pearson and Lipman, 1988, Proc. Natl Acad. Sci. USA 85, 2444]의 유사성 검색 방법을 통해, 또는 이러한 알고리즘을 사용하는 컴퓨터 프로그램(Wisconsin Genetics Software Package(Genetics Computer Group, 575 Science Drive, Madison, Wis.)의 GAP, BESTFIT, FASTA, BLAST P, BLAST N 및 TFASTA)을 통해 수동으로 생성될 수 있다.

일 구현예에서, FGF21 화합물은 서열번호: 250 내지 256으로 이루어진 군으로부터 선택되는 아미노산 서열을 포함하거나 또는 이들로 이루어진 단백질이다.

본 발명에 사용하기에 적합한 FGF21 변이체는 또한, 예를 들어, 본 명세서에 참조로 통합되는 PCT/EP2016/079551에 기재되어 있다.

일 구현예에서, 융합 분자는 A - L₁ - Fc - L₂- B 구조를 갖는 융합 단백질이고, 여기서 A는 GLP-1R 효능제 펩티드이고, L₁, Fc 및 L₂는 본 명세서에 정의된 것과 같고, B는 본 명세서에 정의된 FGF21 화합물이다. 일 구현예에서, 융합 분자는 서열번호: 1 내지 230으로 이루어진 군으로부터 선택되는 아미노산 서열을 포함하거나 또는 이들로 이루어진 융합 단백질이다.

일반적으로, 본 명세서에서 사용되는 용어 "활성 약제학적 성분(Active Pharmaceutical Ingredient)"(API)은 약리학적 효과를 제공하고 본 명세서에 정의된 병태, 예를 들어, 질환 또는 장애를 치료 또는 예방하기 위해 사용되는 임의의 약제학적 활성 화학 또는 생물학적 화합물 및 이의 약제학적으로 허용가능한 염 및 이의 임의의 혼합물을 포함한다.

예시적인 약제학적으로 허용가능한 염은, 하기 산 중 하나 이상으로부터 제조된 염을 포함하지만, 이로만 제한되는 것은 아니다: 염산(예를 들어, 염화물 염), 황산(예를 들어, 황산 염), 질산(예를 들어, 질산염), 인산(예를 들어, 인산염), 브롬화수소산(예를 들어, 브롬화수소염), 말레산(예를 들어, 말레산 염), 말산(예를 들어, 말산 염), 아스코르브산, 시트르산(예를 들어, 시트르산염), 타르타르산(예를 들어, 타르타르산염), 파모산(예를 들어, 파모산염 또는 엠보네이트 염), 라우르산(예를 들어, 라우르산염), 스테아르산(예를 들어, 스테아르산 염), 팔미트산(예를 들어, 팔미트산 염), 올레산, 미리스트산(예를 들어, 미리스트산 염), 라우릴산, 나프탈린설폰산, 리놀렌산(예를 들어, 리놀렌산염 염) 등.

본 명세서에서 사용되는 용어 "활성 약제학적 성분", "활성화제(active agent)", "활성 성분(active ingredient)", "활성 물질(active substance)", "치료적 활성 화합물(therapeutically active compound)" 및 "약물(drug)"은 동의어이다(즉, 동일한 의미를 갖는다).

본 발명에 따르면, 활성 약제학적 성분은 선택적으로 다음으로부터 선택되거나 또는 이들의 임의의 조합물이 적합하다:

- 문헌[Rote Liste 2014]에 언급된 모든 약물, 예를 들어, 문헌[Rote Liste 2014, chapter 12]에 언급된 모든 항당뇨병제(antidiabetic), 문헌[Rote Liste 2014, chapter 06]에 언급된 모든 체중-감소제(weight-reducing agent) 또는 식욕 억제제(appetite suppressant), 문헌[Rote Liste 2014, chapter 58]에 언급된 모든 지질-저하제, 문헌[Rote Liste 2014 chapter 17]에 언급된 모든 항고혈압제, 문헌[Rote Liste]에 언급된 모든 신장보호제(nephroprotective), 또는 문헌[Rote Liste 2014, chapter 36]에 언급된 모든 이뇨제;

- 본 명세서에 정의된 것과 같은 FGF21 화합물;

- 단클론 항체;

- 인슐린 및 인슐린 유도체, 예를 들어, 인슐린 글라진(glargine)(예를 들어 란투스(Lantus)^®), 100 U/mL 초과의 농축된 인슐린 글라진, 예를 들어 270 내지 330 U/mL의 인슐린 글라진 또는 300 U/mL의 인슐린 글라진(EP 2387989에 개시된 바와 같음), 인슐린 글루리신(glulisine)(예를 들어, 아피드라(Apidra)^®), 인슐린 데테미르(detemir)(예를 들어, 레베미르(Levemir)^®), 인슐린 리스프로(lispro)(예를 들어, 휴마로그(Humalog)^®, 리프로로그(Liprolog)^®), 인슐린 데글루데크(degludec)(예를 들어, 데글루데크플러스(DegludecPlus)^®, 이데그리라(IdegLira)(NN9068)), 인슐린 아스파르트 및 아스파르트 제형(예를 들어, 노보로그(NovoLog)^®), 기저 인슐린 및 유사체(예를 들어, LY2605541, LY2963016, NN1436), 페길화된 인슐린 리스프로(예를 들어, LY-275585), 지속성 인슐린(예를 들어, NN1436, 인슈메라(Insumera)(PE0139), AB-101, AB-102, 센슐린(Sensulin) LLC), 중간-작용성 인슐린(예를 들어, 휴뮬린(Humulin)^®N, 노보린(Novolin)^®N), 속효성 및 단기-작용성 인슐린(예를 들어, 휴뮬린^®R, 노보린^®R, 린제타(Linjeta)^®(비아젝트(VIAject)^®), PH20 인슐린, NN1218, 힌스베트(HinsBet)^®), 사전혼합된 인슐린, 술리젠(SuliXen)^®, NN1045, 인슐린 플러스(plus) 심린(Symlin)^®, PE-0139, ACP-002 히드로겔 인슐린, 및 경구, 흡입형, 경피 및 협측 또는 설하 인슐린(예를 들어, 엑수베라(Exubera)^®, 나슐린(Nasulin)^®, 아프레자(Afrezza)^®, 인슐린 트레고필(tregopil), TPM-02 인슐린, 캅슐린(Capsulin)^®, 오랄-린(Oral-lyn)^®, 코발아민(Cobalamin)^® 경구 인슐린, ORMD-0801, 오샤디(Oshadi) 경구 인슐린, NN1953, NN1954, NN1956, 비아탭(VIAtab)^®, 또한, 적합하게는 이관능성 링커에 의해 알부민 또는 또 다른 단백질에 결합되는 인슐린 유도체;

- 글루카곤 유사 펩티드 1(GLP-1), GLP-1 유사체 및 GLP-1 수용체 효능제, 예를 들어, GLP-1(7-37), GLP-1(7-36)아미드, 릭시세나타이드(예를 들어 릭수미아(Lyxumia)^®), 엑세나타이드(예를 들어 엑센딘-4, r엑센딘-4, 바이에타(Byetta)^®, 바이두레온(Bydureon)^®, 엑세나타이드 NexP), 엑세나타이드-LAR, 리라글루타이드(예를 들어, 빅토자(Victoza)^®), 세마글루타이드, 타스포글루타이드, 알비글루타이드, 둘라글루티드, 알부곤, 옥신토모듈린, 게니프로사이드, ACP-003, CJC-1131, CJC-1134-PC, GSK-2374697, PB-1023, TTP-054, 란글레나타이드(HM-11260C), CM-3, GLP-1 엘리젠(Eligen), AB-201, ORMD-0901, NN9924, NN9926, NN9927, 노덱센(Nodexen), 비아도르(Viador)-GLP-1, CVX-096, ZYOG-1, ZYD-1, ZP-3022, CAM-2036, DA-3091, DA-15864, ARI-2651, ARI-2255, 엑세나타이드-XTEN(VRS-859), 엑세나타이드-XTEN + 글루카곤-XTEN(VRS-859 + AMX-808) 및 중합체-결합된 GLP-1 및 GLP-1 유사체;

- 이중 GLP-1/GIP 효능제(예를 들어, RG-7697(MAR-701), MAR-709, BHM081, BHM089, BHM098); 이중 GLP-1/글루카곤 수용체 효능제(예를 들어, BHM-034, OAP-189(PF-05212389, TKS-1225), TT-401/402, ZP2929, LAPS-HMOXM25, MOD-6030);

- 이중 GLP-1/가스트린 효능제(예를 들어 ZP-3022);

- 위장관 펩티드, 예컨대 펩티드 YY 3-36(PYY3-36) 또는 이의 유사체 및 췌장 폴리펩티드(PP) 또는 이의 유사체;

- 글루카곤 수용체 효능제 또는 길항제, 글루코오스 의존성 인슐린 분비성(insulinotropic) 폴리펩티드(GIP) 수용체 효능제 또는 길항제, 그렐린 길항제 또는 역효능제, 제닌 및 이의 유사체;

- 디펩티딜 펩티다아제-IV(DPP-4) 억제제, 예를 들어, 알로글립틴(예를 들어, 네시나(Nesina)^®, 카자노(Kazano)^®), 리나글립틴(예를 들어, 온데로(Ondero)^®, 트라젠타(Trajenta)^®, 트라드젠타(Tradjenta)^®, 트라이엔타(Trayenta)^®), 삭사글립틴(예를 들어, 온글리자(Onglyza)^®, 콤보글라이제(Komboglyze) XR^®), 시타글립틴(예를 들어, 자누비아(Januvia)^®, 셀레비아(Xelevia)^®, 테사벨(Tesavel)^®, 자누메트(Janumet)^®, 벨메티아(Velmetia)^®, 주비싱크(Juvisync)^®, 자누메트 XR^®), 아나글립틴, 테네리글립틴(예를 들어, 테넬리아(Tenelia)^®), 트렐라글립틴, 빌다글립틴(예를 들어, 갈부스(Galvus)^®, 갈부메트(Galvumet)^®), 제미글립틴, 오마리글립틴, 에보글립틴, 듀토글립틴, DA-1229, MK-3102, KM-223, KRP-104, PBL-1427, 피녹사신(Pinoxacin) 히드로클로라이드, 및 Ari-2243;

- 소듐-의존성 글루코오스 수송체 2(SGLT-2) 억제제, 예를 들어, 카나글리플로진, 다파글리플로진, 레모글리플로진, 레모글리플로진 에타보네이트, 세르글리플로진, 엠파글리플로진, 이프라글리플로진, 토포글리플로진, 루세오글리플로진, 에르투글리플로진, EGT-0001442, LIK-066, SBM-TFC-039, 및 KGA-3235(DSP-3235);

- SGLT-2와 SGLT-1의 이중 억제제(예를 들어, LX-4211, LIK066).

- SGLT-1 억제제(예를 들어 LX-2761, KGA-3235) 또는 회장 담즙산 수송(ileal bile acid transfer; IBAT) 억제제(예를 들어 GSK-1614235 + GSK-2330672)와 같은 항비만약과 조합된 SGLT-1 억제제;

- 비구아니드(예를 들어 메트포르민, 부포르민, 펜포르민);

- 티아졸리딘디온(예를 들어 피오글리타존, 로시글리타존), 글리타존 유사체(예를 들어 로베글리타존);

- 퍼옥시좀 증식인자 활성화 수용체(PPAR)(-알파, -감마 또는 -알파/감마) 효능제 또는 조절제(예를 들어 사로글리타자르(예를 들어, 리파글린(Lipaglyn)^®), GFT-505), 또는 PPAR 감마 부분 효능제(예를 들어, Int-131);

- 술포닐우레아(예를 들어, 톨부타미드, 글리벤클라미드, 글리메피리드, 아마릴(Amaryl)^®, 글리피지드) 및 메글리티니드(예를 들어, 나테글리니드, 레파글리니드, 미티글리니드);

- 알파-글루코시다아제 억제제(예를 들어, 아카르보스, 미글리톨, 보글리보스);

- 아밀린 및 아밀린 유사체(예를 들어, 프람린티드, 심린(Symlin)^®);

- G-단백질 커플링 수용체 119(GPR119) 효능제(예를 들어, GSK-1292263, PSN-821, MBX-2982, APD-597, ARRY-981, ZYG-19, DS-8500, HM-47000, YH-Chem1);

- GPR40 효능제(예를 들어, TUG-424, P-1736, P-11187, JTT-851, GW9508, CNX-011-67, AM-1638, AM-5262);

- GPR120 효능제 및 GPR142 효능제;

- 전신성 또는 저흡수성 TGR5(GPBAR1 = G-단백질 커플링된 담즙산 수용체 1) 효능제(예를 들어, INT-777, XL-475, SB756050);

- 당뇨병 면역치료제, 예를 들어, 경구 C-C 케모카인 수용체 타입 2(CCR-2) 길항제(예를 들어, CCX-140, JNJ-41443532), 인터루킨 1 베타(IL-1ß) 길항제(예를 들어, AC-201), 또는 경구 단클론 항체(mAb)(예를 들어, 메탈로자미드, VVP808, PAZ-320, P-1736, PF-05175157, PF-04937319);

- 대사 증후군 및 당뇨병의 치료를 위한 소염제, 예를 들어, 핵 인자 카파 B 억제제(예를 들어, 트리오렉스(Triolex)^®);

- 아데노신 모노포스페이트-활성화되는 단백질 키나아제(AMPK) 자극제, 예를 들어 이메글리민(Imeglimin)(PXL-008), 데비오(Debio)-0930(MT-63-78), R-118;

- 11-베타-히드록시스테로이드 데히드로게나아제 1(11-베타-HSD-1)의 억제제(예를 들어, LY2523199, BMS770767, RG-4929, BMS816336, AZD-8329, HSD-016, BI-135585);

- 글루코키나아제의 활성화제(예를 들어, PF-04991532, TTP-399(GK1-399), GKM-001(ADV-1002401), ARRY-403(AMG-151), TAK-329, TMG-123, ZYGK1);

- 디아실글리세롤 O-아실트랜스퍼라아제(diacylglycerol O-acyltransferase; DGAT)의 억제제(예를 들어, 프라디가스타트(pradigastat(LCQ-908))), 단백질 티로신 포스파타아제 1의 억제제(예를 들어, 트로두스퀘민(trodusquemine)), 글루코오스-6-포스파타아제의 억제제, 프룩토스-1,6-비스포스파타아제의 억제제, 글리코겐포스포릴라아제의 억제제, 포스포에놀 피루베이트 카르복시키나아제의 억제제, 글리코겐 신타아제 키나아제의 억제제, 피루베이트 데히드로게나아제 키나아제의 억제제;

- 글루코오스 수송자-4의 조절제, 소마토스타틴 수용체 3 효능제(예를 들어, MK-4256);

- 하나 이상의 지질 저하제가 또한 병용 파트너로서 적합함. 예를 들어 3-히드록시-3-메틸글루타릴-조효소 A-리덕타아제(HMG-CoA-리덕타아제) 억제제, 예컨대 심바스타틴(예를 들어, 조코르(Zocor)^®, 이네기(Inegy)^®, 심코르(Simcor)^®), 아토르바스타틴(예를 들어, 소르티스(Sortis)^®, 카듀엣(Caduet)^®), 로수바스타틴(예를 들어, 크레스토르(Crestor)^®), 프라바스타틴(예를 들어, 리포스타트(Lipostat)^®, 셀리프란(Selipran)^®), 플루바스타틴(예를 들어 레스콜(Lescol)^®), 피타바스타틴(예를 들어, 리바조(Livazo)^®, 리발로(Livalo)^®), 로바스타틴(예를 들어, 메바코르(Mevacor)^®, 아드비코르(Advicor)^®), 메바스타틴(예를 들어, 컴팩틴(Compactin)^®), 리바스타틴, 세리바스타틴(리포베이(Lipobay)^®), 피브레이트, 예컨대, 베자피브레이트(예를 들어, 세두르(Cedur)^®리타드(retard)), 시프로피브레이트(예를 들어, 하이퍼리펜(Hyperlipen)^®), 페노피브레이트(예를 들어, 안타라(Antara)^®, 리포펜(Lipofen)^®, 리판틸(Lipanthyl)^®), 겜피브로질(예를 들어 로피드(Lopid)^®, 게빌론(Gevilon)^®), 에토피브레이트, 심피브레이트, 로니피브레이트, 클리노피브레이트, 클로피브리드, 니코틴산 및 이의 유도체(예를 들어, 니아신의 서방성 제형을 포함하는 니아신), 니코틴산 수용체 1 효능제(예를 들어, GSK-256073), PPAR-델타 효능제, 아세틸-CoA-아세틸트랜스퍼라아제(ACAT) 억제제(예를 들어, 아바시미브(avasimibe)), 콜레스테롤 흡수 억제제(예를 들어, 에제티미브, 에제트롤(Ezetrol)^®, 제티아(Zetia)^®, 립트루젯(Liptruzet)^®, 바이토린(Vytorin)^®, S-556971), 담즙산-결합 물질(예를 들어, 콜레스티라민, 콜레세벨람), 회장 담즙산 수송(IBAT) 억제제(예를 들어, GSK-2330672, LUM-002), 미세소체 트리글리세리드 운반 단백질(MTP) 억제제(예를 들어, 로미타피드(AEGR-733), SLx-4090, 그라노타피드), 전구단백질 컨버타아제 서브틸리신/켁신 타입 9(proprotein convertase subtilisin/kexin type 9; PCSK9)의 조절제(예를 들어, 알리로쿠맙(REGN727/SAR236553), AMG-145, LGT-209, PF-04950615, MPSK3169A, LY3015014, ALD-306, ALN-PCS, BMS-962476, SPC5001, ISIS-394814, 1B20, LGT-210, 1D05, BMS-PCSK9Rx-2, SX-PCK9, RG7652), LDL 수용체 상향조절제, 예를 들어, 간 선택성 갑상선 호르몬 수용체 베타 효능제(예를 들어, 에프로티롬(KB-2115), MB07811, 소베티롬(QRX-431), VIA-3196, ZYT1), HDL-상승화합물, 예컨대, 콜레스테릴 에스테르 전달 단백질(cholesteryl ester transfer protein; CETP) 억제제(예를 들어 아나세트라핍(MK0859), 달세트라핍, 에바세트라핍, JTT-302, DRL-17822, TA-8995, R-1658, LY-2484595, DS-1442), 또는 이중 CETP/PCSK9 억제제(예를 들어, K-312), ATP-결합 카세트(ABC1) 조절제, 지질 대사 조절제(예를 들어, BMS-823778, TAP-301, DRL-21994, DRL-21995), 포스포리파아제 A2(PLA2) 억제제(예를 들어, 다라플라딥, 타이리사(Tyrisa)^®, 바레스플라딥, 릴라플라딥), ApoA-I 증강제(예를 들어, RVX-208, CER-001, MDCO-216, CSL-112), 콜레스테롤 합성 억제제(예를 들어, ETC-1002), 지질 대사 조절제(예를 들어, BMS-823778, TAP-301, DRL-21994, DRL-21995) 및 오메가-3 지방산 및 이의 유도체(예를 들어, 이코사펜트 에틸(AMR101), 에파노바(Epanova)^®, AKR-063, NKPL-66, PRC-4016, CAT-2003);

- 브로모크립틴(예를 들어, 사이클로세트(Cycloset)^®, 팔로델(Parlodel)^®), 펜테르민 및 펜테르민 제형 또는 조합물(예를 들어, 아디펙스(Adipex)-P, 이오나민(Ionamin), 큐시미아(Qsymia)^®), 벤즈페타민(예를 들어, 디드렉스(Didrex)^®), 디에틸프로피온(예를 들어, 테누에이트(Tenuate)^®), 펜디메트라진(예를 들어, 아디포스트(Adipost)^®, 본트릴(Bontril)^®), 부프로피온 및 조합물(예를 들어, 자이반(Zyban)^®, 웰부트린(Wellbutrin) XL^®, 콘트라브(Contrave)^®, 엠파틱(Empatic)^®), 시부트라민(예를 들어, 리덕틸(Reductil)^®, 메리디아(Meridia)^®), 토피라마트(예를 들어, 토파맥스(Topamax)^®), 조니사미드(예를 들어, 조네그란(Zonegran)^®), 테소펜신, 오피오이드 길항제, 예컨대 날트렉손(예를 들어, 날트렉신(Naltrexin)^®, 날트렉손 + 부프로피온), 칸나비노이드 수용체 1(CB1) 길항제(예를 들어, TM-38837), 멜라닌-농축 호르몬(MCH-1) 길항제(예를 들어, BMS-830216, ALB-127158(a)), MC4 수용체 작용제 및 부분 효능제(예를 들어, AZD-2820, RM-493), 신경펩티드 Y5(NPY5) 또는 NPY2 길항제(예를 들어, 벨네페리트, S-234462), NPY4 효능제(예를 들어, PP-1420), 베타-3-아드레날린 수용체 효능제, 렙틴 또는 렙틴 모방체, 5-히드록시트립타민 2c(5HT2c) 수용체의 효능제(예를 들어, 로르카세린, 벨비크(Belviq)^®), 프람린티드/메트렐렙틴, 리파아제 억제제, 예컨대 세틸리스타트(예를 들어, 카메토르(Cametor)^®), 오르리스타트(예를 들어, 제니칼(Xenical)^®, 칼로발린(Calobalin)^®), 혈관형성 억제제(예를 들어, ALS-L1023), 베타히스티딘 및 히스타민 H3 길항제(예를 들어, HPP-404), AgRP(아구티 관련 단백질) 억제제(예를 들어, TTP-435), 세로토닌 재흡수 억제제, 예를 들어, 플루옥세틴(예를 들어, 플룩틴(Fluctine)^®), 둘록세틴(예를 들어, 심발타(Cymbalta)^®), 이중 또는 삼중 모노아민 흡수 억제제(도파민, 노르에피네프린 및 세로토닌 재흡수), 예컨대 세르트랄린(예를 들어, 졸로프트(Zoloft)^®), 테소펜신, 메티오닌 아미노펩티다아제 2(MetAP2) 억제제(예를 들어, 벨로라닙), 및 섬유모세포 성장 인자 수용체 4(FGFR4)(예를 들어, ISIS-FGFR4Rx) 또는 프로히비틴 표적화 펩티드-1(예를 들어, 아디포티드(Adipotide)^®)의 생성에 대한 안티센스 올리고뉴클레오티드;

- 산화질소 공여체, AT1 길항제 또는 안지오텐신 II(AT2) 수용체 길항제, 예컨대 텔미사르탄(예를 들어 킨잘(Kinzal)^®, 미카르디스(Micardis)^®), 칸데사르탄(예를 들어 아타칸드(Atacand)^®, 블로프레스(Blopress)^®), 발사르탄(예를 들어 디오반(Diovan)^®, 코-디오반(Co-Diovan)^®), 로사르탄(예를 들어, 코사르(Cosaar)^®), 에프로사르탄(예를 들어, 테베텐(Teveten)^®), 이르베사르탄(예를 들어, 아프로벨(Aprovel)^®, 코아프로벨(CoAprovel)^®), 올메사르탄(예를 들어, 보툼(Votum)^®, 올메텍(Olmetec)^®), 타소사르탄, 아질사르탄(예를 들어, 에다르비(Edarbi)^®), 이중 안지오텐신 수용체 차단제(이중 ARB), 안지오텐신 전환 효소(ACE) 억제제, ACE-2 활성화제, 레닌억제제, 프로레닌 억제제, 엔도텔린 전환 효소(ECE) 억제제, 엔도텔린 수용체(ET1/ETA) 차단제, 엔도텔린 길항제, 이뇨제, 알도스테론 길항제, 알도스테론 신타아제 억제제, 알파-차단제, 알파-2 아드레날린 수용체의 길항제, 베타-차단제, 혼합 알파-/베타-차단제, 칼슘 길항제, 칼슘 채널 차단제(CCB), 칼슘 채널 차단제 딜티아젬의 비강 제형(예를 들어, CP-404), 이중 미네랄로코르티코이드/CCB, 중추 작용성 항고혈압제, 중성 엔도펩티다아제의 억제제, 아미노펩티다아제-A 억제제, 바소펩티드 억제제, 이중 바소펩티드 억제제, 예컨대 네프릴리신-ACE 억제제 또는 네프릴리신-ECE 억제제, 이중-작용 AT 수용체-네프릴리신 억제제, 이중 AT1/ETA 길항제, 최종 당화산물(AGE) 분해제, 재조합 레날라아제, 혈압 백신, 예컨대 항-RAAS(레닌-안지오텐신-알도스테론-시스템) 백신, AT1- 또는 AT2-백신, 고혈압 게놈약학을 기반으로 한 약물, 예컨대 항고혈압 반응을 갖는 유전자 다형성의 조절제, 혈소판 응집 억제제, 등.

특정 예시적 구현예에서, 본 발명에 따른 "핵산 분자(nucleic acid molecule)"는 데옥시리보핵산(DNA) 또는 리보핵산(RNA)이다. 본 발명에 따른 핵산 분자는 단일 가닥 또는 이중 가닥인 분자의 형태일 수 있다. 본 발명에 따른 핵산 분자는 선형이거나 공유적으로 폐쇄되어 원을 형성할 수 있다.

본 명세서에서 사용되는 용어 "DNA"는, 데옥시리보뉴클레오티드 잔기를 포함하며, 예시적인 특정 구현예에서, 전적으로 또는 실질적으로 데옥시리보뉴클레오티드 잔기로 구성된 분자를 지칭한다. 본 명세서에서 사용되는 "데옥시리보뉴클레오티드"는 베타-D-리보푸라노실 기의 2'-위치에 히드록실 기가 결여된 뉴클레오티드를 지칭한다. 용어 "DNA"는 단리된 DNA, 예컨대 부분적으로 또는 완전히 정제된 DNA, 본질적으로 순수한 DNA, 합성 DNA, 및 재조합적으로 생성된 DNA를 포함한다. 용어 "DNA"는 또한 하나 이상의 뉴클레오티드의 부가, 결실, 치환 및/또는 변화에 의해 천연 생성 DNA와는 다른 변형 DNA를 포함한다. 그러한 변화는 DNA의 말단(들)에 또는 내부에, 예를 들어 DNA의 하나 이상의 뉴클레오티드에서의 비-뉴클레오티드 물질의 부가를 포함할 수 있다. DNA 분자에서의 뉴클레오티드는 또한 비-표준 뉴클레오티드, 예컨대 비-천연 생성 뉴클레오티드 또는 화학적 합성 뉴클레오티드를 포함할 수 있다. 이러한 변경된 DNA는 유사체 또는 천연-발생 DNA의 유사체로 지칭될 수 있다.

본 명세서에서 사용되는 용어 "RNA"는 리보뉴클레오티드 잔기를 포함하며 선택적으로 전적으로 또는 실질적으로 리보뉴클레오티드 잔기로 구성된 분자를 지칭한다. 본 명세서에서 사용되는 "리보뉴클레오티드"는 베타-D-리보푸라노실 기의 2'-위치에 히드록실 기를 갖는 뉴클레오티드를 지칭한다. 용어 "RNA"는 단리된 RNA, 예컨대 부분적으로 또는 완전히 정제된 RNA, 본질적으로 순수한 RNA, 합성 RNA, 및 재조합적으로 생성된 RNA를 포함한다. 용어 "RNA"는 또한, 하나 이상의 뉴클레오티드의 부가, 결실, 치환 및/또는 변화에 의해 천연 생성 RNA와는 다른 변형 RNA를 포함한다. 그러한 변화는 RNA의 말단(들)에 또는 내부에, 예를 들어, RNA의 하나 이상의 뉴클레오티드에서 비-뉴클레오티드 물질의 부가를 포함할 수 있다. RNA 분자에서의 뉴클레오티드는 또한 비-표준 뉴클레오티드, 예컨대 비-천연 생성 뉴클레오티드 또는 화학적 합성 뉴클레오티드 또는 데옥시뉴클레오티드를 포함할 수 있다. 변경된 RNA 분자는 유사체 또는 천연-발생 RNA의 유사체로 지칭될 수 있다. 본 발명에 따르면, "RNA"는 단일 가닥 RNA 또는 이중 가닥 RNA를 지칭한다. 일 구현예에서, RNA는 mRNA, 예를 들어, 시험관 내에서 전사된 RNA(IVT RNA) 또는 합성 RNA이다. 또한 RNA는, 예를 들어 RNA의 안정성(예를 들어, 반감기)을 증가시키는 하나 이상의 변형에 의해 변형될 수 있다. 그러한 변형은 당업자에게 공지되어 있으며, 예를 들어 5'-캡(cap) 또는 5'캡 유사체를 포함한다.

뉴클레오티드와 관련하여 사용되는 경우, "천연 생성(naturally occurring)"이라는 용어는 염기 아데닌(A), 시토신(C), 구아닌(G), 티민(T) 및 우라실(U)을 지칭한다.

본 발명에 따른 핵산 분자는 벡터 내에 함유/포함될 수 있다. 본 명세서에서 사용되는, 용어 "벡터(vector)"는 당업자에게 공지된 모든 벡터를 포함하며, 이는 플라스미드 벡터, 코스미드 벡터, 파지 벡터(예를 들어, 람다 파지), 바이러스 벡터(예를 들어, 아데노바이러스 또는 베큘로바이러스 벡터), 또는 인공 염색체 벡터(예를 들어, 박테리아 인공 염색체(Bacterial Artificial Chromosome; BAC), 효모 인공 염색체(Yeast Artificial Chromosome; YAC), 또는 P1 인공 염색체(PAC))를 포함한다. 상기 벡터는 발현 벡터와 클로닝 벡터를 포함한다. 발현 벡터는 플라스미드와 바이러스 벡터를 포함하며, 일반적으로, 원하는 코딩 서열 및 특정 숙주 유기체(예를 들어, 박테리아, 효모, 식물, 곤충류, 포유류 등)에서 또는 시험관 내 발현 시스템에서의 작동가능하게 연결된 코딩 서열의 발현에 필요한 적절한 DNA 서열을 포함한다. 일반적으로 클로닝 벡터는 특정한 원하는 DNA 단편의 엔지니어링 및 증폭에 사용되며, 원하는 DNA 단편의 발현에 필요한 기능성 서열이 결여될 수 있다.

대안적으로, 본 발명에 따른 핵산 분자는 게놈, 예를 들어 숙주 세포의 게놈 내로 통합될 수 있다. 특정 핵산 분자를 게놈 내로 통합시키는 수단 및 방법은 당업자에게 널리 공지되어 있다.

본 명세서에서 사용되는 용어 "세포(cell)" 또는 "숙주 세포(host cell)"는 온전한 세포, 즉, 효소, 소기관, 또는 유전 물질과 같은 보통의 세포내 성분을 방출하지 않은 온전한 막을 갖는 세포를 지칭한다. 예시적인 특정 구현예에서, 온전한 세포는 생존가능 세포, 즉, 이의 정상적인 대사 기능을 수행할 수 있는 살아있는 세포이다. 특정 예시적인 구현예에서, 세포 또는 숙주 세포는 외인성 핵산으로 형질감염되거나 형질전환될 수 있는 임의의 세포이다. 특정 예시적인 구현예에서, 외인성 핵산으로 형질감염되거나 형질전환되어 수용체로 전달되는 경우, 세포는 해당 수용체에서 상기 핵산을 발현할 수 있다.

용어 "세포"는 원핵 세포, 예컨대, 박테리아 세포, 및 진핵 세포, 예컨대 효모 세포, 진균류 세포 또는 포유류 세포를 포함한다. 적합한 박테리아 세포는 그람(gram)-음성 박테리아 균주, 예컨대 에스케리키아 콜라이(Escherichia coli), 프로테우스(Proteus), 및 슈도모나스(Pseudomonas)의 균주, 및 그람-양성 박테리아 균주, 예컨대 바실루스(Bacillus), 스트렙토마이세스(Streptomyces), 스타필로코커스(Staphylococcus), 및 락토코커스(Lactococcus)의 균주로부터의 세포를 포함하지만, 이에 제한되지 않는다. 적합한 진균류 세포는 트리코데르마(Trichoderma), 뉴로스포라(Neurospora) 및 아스페르길루스(Aspergillus)의 종으로부터의 세포를 포함하지만, 이에 제한되지 않는다. 적합한 효모 세포는 사카로마이세스(Saccharomyces) 종(예를 들어, 사카로마이세스 세레비지애(Saccharomyces cerevisiae)), 스키조사카로마이세스(Schizosaccharomyces) 종(예를 들어, 스키조사카로마이세스 폼베(Schizosaccharomyces pombe)), 피키아(Pichia) 종(예를 들어, 피키아 파스토리스(Pichia pastoris) 및 피키아 메타놀리카(Pichia methanolica)) 및 한세눌라(Hansenula) 종으로부터의 세포를 포함하지만, 이에 제한되지 않는다. 적합한 포유류 세포는, 이로만 제한되는 것은 아니지만, 예를 들어 CHO 세포, BHK 세포, HeLa 세포, COS 세포, HEK-293 등을 포함한다. 일 구현예에서, HEK-293 세포가 사용된다. 그러나, 양서류 세포, 곤충 세포, 식물 세포, 및 이종성 단백질의 발현을 위하여 당업계에서 사용되는 임의의 다른 세포가 또한 사용될 수 있다. 예시적인 특정 구현예에서, 포유류 세포(예를 들어, 인간, 마우스, 햄스터, 돼지, 염소, 또는 영장류로부터의 세포)는 입양 전달에 사용된다.

적합한 세포는 다수의 조직 유형으로부터 유래할 수 있으며, 일차 세포 및 세포주, 예컨대 면역계 세포(예를 들어, 수지상 세포 및 T 세포와 같은 항원 제시 세포, 조혈 줄기 세포 및 중간엽 줄기 세포와 같은 줄기 세포)뿐만 아니라, 임의의 다른 세포 유형을 포함한다.

본 명세서에서 사용되는 "항원-제시 세포(antigen-presenting cell)"는 주조직적합성 복합체의 맥락에서 항원을 표면 상에 제시하는 세포이다. T 세포는 조직적합성 복합체를 그의 T 세포 수용체(TCR)를 사용하여 인식할 수 있다.

세포 또는 숙주 세포는 단리되거나, 조직 또는 유기체, 특히 "비-인간 유기체"의 일부일 수 있다. 본 명세서에서 사용되는 용어 "비-인간 유기체(non-human organism)"는 비-인간 영장류 또는 기타 동물, 예를 들어, 포유류, 예컨대, 소, 말, 돼지, 양, 염소, 개, 고양이, 토끼 또는 설치류(예를 들어, 마우스, 래트, 기니피그 및 햄스터)를 포함하고자 한다.

본 발명에 따른 약제학적 조성물은 하나 이상의 담체 및/또는 부형제를 포함하며, 이들 모두 약제학적으로 허용가능하다. 본 명세서에서 사용되는 용어 "약제학적으로 허용가능한(pharmaceutically acceptable)"은 예시적인 특정 구현예에서 약제학적 조성물의 활성화제의 작용과 상호작용하지 않는 물질의 무독성을 지칭한다.

본 명세서에서 사용되는 용어 "담체(carrier)"는 활성 성분의 적용을 용이하게 하거나, 증강시키거나 가능하게 하기 위하여 조합되는, 천연 또는 합성 성질의 유기 또는 무기 성분을 지칭한다. 본 발명에 따르면, 용어 "담체"는 대상체에게 투여하기에 적합한 하나 이상의 상용성 고체 또는 액체 충전제, 희석제 또는 캡슐화 물질을 또한 포함한다.

비경구 투여용으로 적합한 담체 물질은 멸균수, 링거액(Ringer's solution), 락테이트 링거액(Lactated Ringer's solution), 생리식염수, 정균 식염수(예를 들어, 0.9% 벤질 알코올을 함유하는 식염수), 인산염 완충 염수(PBS), 행크 용액(Hank's solution), 폴리알킬렌 글리콜, 수소화 나프탈렌 및 특히 생체적합성 락티드 중합체, 락티드/글리콜리드 공중합체 또는 폴리옥시에틸렌/폴리옥시-프로필렌 공중합체를 포함하지만 이에 제한되지 않는다.

본 명세서에서 사용되는 용어 "부형제(excipient)"는 약제학적 조성물에 존재할 수 있고 활성 성분이 아닌 모든 물질, 예컨대 염, 결합제(예를 들어, 락토스, 덱스트로스, 수크로스, 트레할로스, 소르비톨, 만니톨), 충전제, 활택제, 증점제, 표면 활성화제, 방부제, 유화제, 완충 물질, 착향제, 또는 착색제를 포함하고자 한다.

약제학적으로 허용가능한 것이 아닌 염이 약제학적으로 허용가능한 염의 제조에 사용될 수 있으며, 이들은 본 발명에 포함된다. 이러한 종류의 약제학적으로 허용가능한 염은, 비제한적 방식으로, 염화수소산, 브롬화수소산, 황산, 질산, 인산, 말레산, 아세트산, 살리실산, 시트르산, 포름산, 말론산, 숙신산 등과 같은 산으로부터 제조되는 것을 포함한다. 약제학적으로 허용가능한 염은 또한 알칼리 금속염 또는 알칼리 토금속염, 예컨대 나트륨염, 칼륨염 또는 칼슘염으로 제조될 수 있다. 염은 약제학적 조성물의 이온 강도 또는 장성을 조정하기 위하여 첨가될 수 있다.

약제학적 조성물에서 사용하기에 적합한 방부제는 산화방지제, 시트르산, 시트르산나트륨, 벤잘코늄 클로라이드, 클로로부탄올, 시스테인, 메티오닌, 파라벤, 티메로살, 페놀, 크레졸, 및 이들의 혼합물을 포함하지만, 이에 제한되는 것은 아니다.

약제학적 조성물에서 사용하기에 적합한 완충 물질은 염 형태의 아세트산, 염 형태의 시트르산, 염 형태의 붕산, 염 형태의 인산, 및 트리스(히드록시메틸)아미노메탄(트리스, THAM, 트로메타몰)을 포함하지만, 이에 제한되는 것은 아니다.

예시적인 특정 구현예에서, 본 발명에 따른 약제학적 조성물은 무균이다. 약제학적 조성물은 균일한 투약 형태로 제공될 수 있으며, 당업자에게 공지된 임의의 방식으로 제조될 수 있다. 약제학적 조성물은, 예를 들어, 용액 또는 현탁액의 형태일 수 있다.

또한 약제학적 조성물은 상기에 정의된 바와 같은 하나 이상의 부형제를 선택적으로 포함하는, 적절한 희석제로 재구성되는 안정한 동결건조 생성물로 제형화될 수 있다.

본 발명에 따른 약제학적 조성물은 GLP-1R 효능 펩티드 이외에 적어도 하나의 다른 활성 약제학적 성분을 추가로 포함할 수 있다.

본 명세서에서 사용되는, 용어 "부품 키트(kit of parts)(줄여서, 키트)"는 하나 이상의 용기 및 선택적으로 데이터 운반체를 포함하는 제조 물품을 지칭한다. 상기 하나 이상의 용기는 본 발명의 상기 언급한 작용제, 예를 들어, GLP-1R 효능제 펩티드, 융합 단백질, 약제학적 조성물 및 관련 작용제, 예컨대 핵산 분자 및 숙주 세포 중 하나 이상으로 충전될 수 있다. 예를 들어, 희석제, 완충제 및 추가 시약을 포함하는 추가 용기가 키트에 포함될 수 있다. 상기 데이터 운반체는 비-전자 데이터 운반체, 예를 들어, 그래픽 데이터 운반체, 예컨대 정보 전단, 정보 시트, 바코드 또는 접속 코드, 또는 전자 데이터 운반체, 예컨대 콤팩트 디스크(CD), 디지털 다목적 디스크(DVD), 마이크로칩 또는 또 다른 반도체-기반 전자 데이터 운반체일 수 있다. 접속 코드는 데이터베이스, 예를 들어 인터넷 데이터베이스, 중앙 집중식 또는 분산 데이터베이스에 접속할 수 있게 한다. 상기 데이터 운반체는, 본 명세서에 기재된 바와 같은, 본 발명의 작용제, 예를 들어, GLP-1R 효능제 펩티드, 융합 분자 약제학적 조성물 및 관련 작용제, 예컨대 핵산 분자 및 숙주 세포의 사용에 대한 지침을 포함할 수 있다.

본 명세서에 기재된 작용제 및 조성물은 임의의 통상적인 경로를 통하여 투여될 수 있으며, 예를 들어, 경구 투여되거나, 폐 투여되거나, 흡입에 의해 투여되거나, 주사 또는 주입에 의한 것을 포함하여 비경구로 투여될 수 있다. 일 구현예에서, 비경구 투여, 예를 들어, 정맥내, 동맥내, 피하, 피내 또는 근육내 투여가 사용된다. 본 명세서에 기재된 작용제 및 조성물은 또한 지속 방출 투여를 통하여 투여될 수 있다.

비경구 투여에 적합한 약제학적 조성물은 통상적으로 활성 화합물의 멸균 수성 또는 비수성 제제를 포함하며, 상기 제제는 선택적으로 수용체의 혈액에 대하여 등장성이다. 상용성 담체/용매/희석제의 예로는 멸균수, 링거액, 락테이트 링거액, 생리식염수, 정균 식염수(예를 들어, 0.9% 벤질 알코올을 함유하는 식염수), PBS 및 행크 용액이 있다. 또한, 일반적으로 멸균된 고정유(fixed oil)가 용액 또는 현탁액 매질로서 사용될 수 있다.

본 명세서에 기재된 작용제 및 조성물은 일반적으로 치료적 유효량으로 투여된다. "치료적 유효량(therapeutically effective amount)"은 원하는 치료 반응 또는 원하는 치료 효과를 단독으로 또는 추가 용량과 함께, 선택적으로 허용할 수 없거나 원하지 않는 부작용을 일으키지 않거나 최소한으로만 일으키는 양을 지칭한다.

예시적인 특정 구현예에서, 특정 질환, 특정 장애, 또는 특정 병태를 치료하는 경우, 원하는 반응은 해당 질환, 장애 또는 병태의 경과의 억제와 관련될 수 있다. 이것은 질환, 장애 또는 병태의 진행을 늦추는 것, 특히 질환, 장애 또는 병태의 진행을 방해하거나 역전시키는 것을 포함한다. 질환, 장애 또는 병태의 치료에서의 원하는 반응은 또한 상기 질환, 장애 또는 병태의 발병 지연 또는 발병 예방일 수 있다. 본 명세서에 기재된 작용제 또는 조성물의 유효량은 치료될 병태, 질환, 장애 또는 병태의 중증도, 대상체의 연령, 신체 상태, 크기 및 체중을 비롯한 개별 파라미터, 치료 지속 기간, (존재할 경우) 수반되는 치료법의 유형, 특정 투여 경로 및 유사 요인에 따라 달라질 것이다. 따라서, 본 명세서에 기재된 작용제의 투여 용량은 그러한 다양한 파라미터에 따라 달라질 수 있다. 대상체에서의 반응이 처음 용량으로 불충분한 경우, 더 높은 용량(또는, 더 국소화된 상이한 투여 경로에 의해 달성되는 효과적으로 더 높은 용량)이 사용될 수 있다.

본 발명에 따르면, 용어 "질환(disease), 장애(disorder) 또는 병태(condition)"는 임의의 병리학적 상태 또는 건강하지 않은 상태, 특히 비만, 과체중, 대사 증후군, 진성 당뇨병, 당뇨병성 망막증, 고혈당증, 이상지질혈증, NASH 및/또는 아테롬성 동맥경화증을 지칭한다.

본 명세서에서 사용되는 용어 "비만(obesity)"은 과도한 체지방이 건강에 부정적인 영향을 줄 수 있을 정도까지 축적된 의학적 병태를 지칭한다. 인간(성인) 대상체의 측면에서, 비만은 30 kg/㎡ 이상의 체질량 지수(body mass index; BMI)(BMI ≥ 30 kg/㎡)로 정의될 수 있다.

본 명세서에서 사용되는 어구 "과체중(being overweight)"은 체지방량이 최적으로 건강한 경우에 비해 더 높은 의학적 병태를 지칭한다. 인간(성인) 대상체의 측면에서, 비만은 25 kg/㎡ 이상의 체질량 지수(BMI)(예를 들어, 25 kg/㎡ ≤ BMI ≤ 30 kg/㎡)로 정의될 수 있다.

BMI는 성인에 있어서 과체중 및 비만을 분류하는 데 일반적으로 사용되는 간단한 신장 대비 체중의 지수이다. 이것은 kg 단위의 사람의 체중을 미터 단위의 신장의 제곱으로 나눈 것(kg/㎡)으로 정의된다.

본 명세서에서 사용되는 "대사 증후군(Metabolic syndrome)"은 하기의 의학적 병태들 중 적어도 3가지의 클러스터링을 지칭한다: 복부(중심성) 비만(예를 들어, 유럽계 남성의 경우 ≥ 94 cm의 허리 둘레 및 유럽계 여성의 경우 ≥ 80 cm의 허리 둘레로서 정의되며, 다른 군의 경우 민족 특이적 값을 가짐), 상승된 혈압(예를 들어, 130/85 mmHg 이상), 상승된 공복 혈장 글루코오스(예를 들어, 적어도 100 mg/dL), 높은 혈청 트리글리세리드(예를 들어, 적어도 150 mg/dL), 및 낮은 고밀도 리포단백질(HDL) 수준(예를 들어, 남성의 경우 40 mg/dL 미만 및 여성의 경우 50 mg/dL 미만).

본 명세서에서 사용되는 "진성 당뇨병(Diabetes mellitus)"(간단히 "당뇨병(diabetes)"으로도 지칭됨)은 인슐린 생성, 인슐린 작용 또는 이들 둘 다에서의 결함에서 생기는 고수준의 혈중 글루코오스를 특징으로 하는 대사성 질환들의 군을 지칭한다. 일 구현예에서, 진성 당뇨병은 1형 진성 당뇨병, 2형 진성 당뇨병, 임신성 진성 당뇨병, 성인에서의 후기 발병형 자가면역 당뇨병(Late onset Autoimmune Diabetes in the Adult; LADA), 청소년기의 성숙기 발병 당뇨병(Maturity onset Diabetes of the Young; MODY) 및 특정한 유전적 상태, 약물, 영양실조, 감염 및 기타 질병에서 생기는 다른 유형의 당뇨병으로 이루어진 군으로부터 선택된다. 현재의 WHO의 진성 당뇨병 진단 기준은 다음과 같다: 공복 혈장 글루코오스 ≥ 7.0 mmol/l(126 mg/dL) 또는 2-h 혈장 글루코오스 ≥ 11.1 mmol/l (200 mg/dL).

본 명세서에서 사용되는 "1형 진성 당뇨병"("인슐린 의존성 당뇨병(Insulin-Dependent Diabetes Mellitus; IDDM)" 또는 "소아 당뇨병(juvenile diabetes)"으로도 공지됨)은 인슐린의 전적인 결여에 의해 야기되는 고 혈당 수준을 특징으로 하는 병태이다. 이것은 신체 면역계가 췌장에서 인슐린 생산 베타 세포를 공격하여 이를 파괴할 때 일어난다. 그러면 췌장은 인슐린을 거의 생산하지 않거나 전혀 생산하지 않는다. 췌장의 제거 또는 질환은 또한 인슐린-생산 베타 세포의 손실을 초래할 수 있다. 1형 진성 당뇨병은 당뇨병 사례의 5% 내지 10%를 차지한다.

본 명세서에서 사용되는 "2형 진성 당뇨병"("인슐린 비의존성 당뇨병(Non-Insulin-Dependent Diabetes; NIDDM)" 또는 "성인 발병 당뇨병(adult-onset diabetes)"으로도 공지됨)은 인슐린의 이용성에도 불구하고 과도한 글루코오스가 생성되는 것을 특징으로 하는 병태이며, 순환 글루코오스 수준은 부적당한 글루코오스 제거(인슐린 작용)의 결과로서 여전히 과도하게 높은 채로 있다. 2형 진성 당뇨병은 진단된 모든 당뇨병 사례의 약 90% 내지 95%를 차지할 수 있다.

본 명세서에서 사용되는 "임신성 당뇨병(Gestational diabetes)"은 이전에 당뇨병으로 진단되지 않은 여성이 임신 중(특히 임신 후기 중) 높은 혈당 수준을 나타내는 병태이다. 임신성 당뇨병은 연구되는 집단에 따라 임신 사례의 3 내지 10%에 영향을 준다.

본 명세서에서 사용되는 "성인에서의 후기 발병형 자가면역 당뇨병(Late onset Autoimmune Diabetes in the Adult, LADA)"("느린 발병형 제1형 당뇨병"으로도 지칭됨)은 종종 더 느린 발병 과정을 갖는, 성인에서 발생하는 1형 진성 당뇨병 형태이다.

본 명세서에서 사용되는 "청소년기의 성숙기 발병 당뇨병(Maturity Onset Diabetes of the Young, MODY)"은 인슐린 생산을 파괴하는 상염색체 우성 유전자의 돌연변이에 의해 야기되는 유전형의 당뇨병을 지칭한다.

본 명세서에서 사용되는 "당뇨병성 망막증(Diabetic retinopathy)"은 당뇨병 환자에서 발생하는 대사 장애에 의해 유발되는 안구 질환으로, 진행성 시력 저하를 야기한다.

본 명세서에서 사용되는 용어 "고혈당증(hyperglycemia)"은 혈액 중의 과도한 당(글루코오스)을 지칭한다.

본 명세서에서 사용되는 용어 "이상지질혈증(dyslipidemia)"은 리포단백질 과다생성("고지혈증") 또는 결핍("저지혈증")을 포함하는 리포단백질 대사의 장애를 지칭한다. 이상지질혈증은 혈중 총 콜레스테롤, 저밀도 리포단백질(LDL) 콜레스테롤 및/또는 트리글리세리드 농도의 상승, 및/또는 고밀도 리포단백질(HDL) 콜레스테롤 농도의 감소로 나타날 수 있다.

본 명세서에서 사용되는 비알코올성 지방간염(NASH)은 간세포의 염증 및 감퇴와 함께, 지방(지질 소적)의 축적을 특징으로 하는 간질환이다. 일단 개시되면, 이 질환에는 간기능이 변경되고 간부전으로 진행할 수 있는 상태인 고위험도의 간경변이 수반된다. 이 후, NASH는 종종 간암으로 진행된다.

본 명세서에서 사용되는 "죽상동맥경화증(Atherosclerosis)"은 동맥 내강의 협착을 야기하고 섬유증 및 석회화로 진행할 수 있는, 큰 크기 및 중간 크기의 동맥의 내막에서의 경화반으로 칭해지는 불규칙 분포 지질 침적물을 특징으로 하는 혈관 질환을 지칭한다. 병변은 일반적으로 국소(focal) 병변이며, 느리게 그리고 간헐적으로 진행한다. 가끔, 경화반 파열이 일어나서 혈류 폐색을 초래하여 폐색 원위부의 조직사를 야기한다. 혈류 제한이 대부분의 임상 소견을 차지하며, 이는 폐색의 분포 및 중증도에 따라 달라진다.

본 명세서에서 사용되는, 용어 "약제(medicament)"는 치료법에서, 즉, 질환 또는 장애의 치료에 사용되는 물질 및/또는 조성물을 나타낸다.

본 명세서에서 사용되는 용어 "치료하다(treat)"는 대상체에서 질환, 장애 또는 병태를 예방, 완화, 또는 제거하고/하거나; 대상체에서 질환, 장애 또는 병태를 저지 또는 지연시키고/시키거나; 대상체에서 새로운 질환, 장애 또는 병태의 발병을 억제 또는 지연시키고/시키거나; 현재 질환, 장애 또는 병태를 갖고 있거나 이전에 질환, 장애 또는 병태를 갖고 있었던 대상체에서 증상의 빈도 또는 중증도 및/또는 재발을 감소시키고/시키거나; 대상체의 수명을 연장, 즉, 증가시키기 위하여 대상체에게 화합물 또는 조성물 또는 화합물 또는 조성물의 조합물을 투여하는 것을 지칭한다.

특히, 어구 "질환, 장애 또는 병태를 치료하는" 및 "질환, 장애 또는 병태의 치료"는 질환, 장애 또는 병태 또는 이의 증상의 발병의 치유, 지속 기간의 단축, 개선, 예방, 진행 또는 악화의 늦춤 또는 억제, 또는 예방 또는 지연을 포함한다.

용어 "대상체(subject)"는 본 발명에 따르면, 치료를 위한 대상체, 특히 질환에 걸린 대상체("환자(patient)"로도 지칭됨)를 지칭하며, 인간, 비-인간 영장류, 또는 기타 동물, 예를 들어, 포유류, 예컨대 소, 말, 돼지, 양, 염소, 개, 고양이, 토끼 또는 설치류(예를 들어, 마우스, 래트, 기니피그 또는 햄스터)를 포함하지만, 이로 제한되지 않는다. 일 구현예에서, 대상체/환자는 인간이다.

이하, 본 발명을 하기 실시예를 참고하여 더 구체적으로 설명하지만, 이는 본 발명의 범주를 제한하려는 것이 아니라 예시하고자 하는 것이다.

실시예

실시예 1: 시스템 약리학 모델링을 통한 최적의 GLP-1RA/FGF21 활성 비율 결정

인간에서 GLP-1RA/FGF21 융합 단백질의 약리학적 효과에 대한 개선된 기계적 통찰력을 사용하여 최적의 GLP-1RA/FGF21 효능 비율을 확인했다. 인간의 글루코오스, 지질 및 에너지 대사에 대한 GLP-1 및 FGF21의 영향을 기재하는 기계론적 시스템 약리학 모델을 개발하였다(Cuevas-Ramos et al. (2009) Curr Diabetes Rev 5(4): 216-220; Deacon et al. (2011) Rev Diabet Stud 8(3): 293-306; Kim et al. (2008) Pharmacol Rev 60(4): 470-512; Kharitonenkov et al. (2014) Mol Metab 3(3): 221-229).

이 모델은 GLP-1 및 FGF21 효과에 대한 관련 경로를 나타냈다. 혈당 제어(즉, HbA1c, 공복 혈장 글루코오스, 식후 글루코오스), 지질 매개변수(즉, 혈장 트리글리세리드, 지방산, 콜레스테롤), 및 에너지 균형(즉, 체중, 음식 섭취량, 에너지 소비)를 포착하여 시뮬레이션된 약물 치료(예를 들어, GLP-1RA/FGF21 융합 단백질, 리라글루티드, FGF21 유사체 LY2405319)에 대한 치료 반응을 평가했다. LY2405319의 경우, 문헌[Kharitonenkov et al. (2013) PLoS ONE 8(3): e58575]을 참조한다.

이 모델은 호르몬 인슐린, 글루카곤, 및 특정 인크레틴(예를 들어, GLP-1, GIP)에 의해 제어되는 글루코오스 항상성의 주요 양태를 다루었다. 혈당 제어에 관한 주요 모델 평가변수는 HbA1c이었다. HbA1c는 이전의 수개월 동안에 걸친 평균 혈장 글루코오스 농도를 추정하는 데 사용되는 일반적인 임상 평가변수이다. 문헌[Nathan et al. (2008) Diabetes Care 31(8): 1473-1478]에 보고된 바와 같이, 평균 혈장 글루코오스와 HbA1c 사이의 선형 상관관계를 사용하여 HbA1c를 모델내에서 추정하였다.

이 모델은 콜레스테롤 표현을 포함하여 기본 지질 대사를 처리하기에 적절한 수준에서 트리글리세리드와 지방산 대사를 도입했다. HDL 및 비-HDL, 즉, LDL + VLDL 콜레스테롤은 순환하는 리포단백질이다. 지질 대사의 표현은 지질에 대한 FGF21 화합물의 영향 및 스타틴과의 상호작용을 시뮬레이션할 수 있게 하였다. FGF21 화합물은 지질 농도에 유의한 영향을 미쳤다(Gaich et al. (2013) Cell Metab 18(3): 333-340; Fisher et al. (2011) Endocrinology 152(8): 2996-3004).

모델의 체중 감소 또는 증가를 체지방량의 변화로 측정하였다. 체지방과 체중 간에는 직접적인 관계가 있었다(Broyles et al. (2011) Br J Nutr 105(8): 1272-1276). 음식물 섭취량은 기초 및 휴식 신진대사율에 기반을 두었다(Amirkalali et al. (2008) Indian J Med Sci 62(7): 283-290). 에너지 소비가 칼로리 섭취량과 같을 때 체지방량은 일정하게 유지되었다. 음식물 섭취에 대한 치료 효과를 문헌(Gobel et al. (2014) Obesity (Silver Spring) 22(10): 2105-2108)의 제형을 사용한 모델에서 구현하였다.

음식물은 탄수화물(글루코오스 당량), 지방(지방산 당량) 및 단백질(아미노산 당량)인 것으로 간주되었다. 모든 영양소는 위장에 들어갔고, 지연 노드를 통과한 다음, 3-구획의 위장관으로 들어갔다. 위장관 설계는 음식물 소화 및 흡수에 관한 문헌(Bastianelli et al. (1996) J Anim Sci 74(8): 1873-1887; 및 Worthington (1997) Med Inform (Lond) 22(1): 35-45)에 의해 수행된 작업에 기반했다.

영양분, 호르몬, 약물 및 질환 상태는 위장 배출 지연을 일으킬 수 있다. 건강한 상태에서 위장 배출 속도는 식사의 규모, 이의 에너지 밀도 및 위내 영양분의 양에 따라 결정된다(Achour et al. (2001) Eur J Clin Nutr 55(9): 769-772; Fouillet et al. (2009) Am J Physiol Regul Integr Comp Physiol 297(6): R1691-1705). 당뇨병이 있는 개체는 경구 글루코오스 내성 검사 또는 식사 검사에서 글루코오스 흡수가 종종 지연되는 것으로 관찰되었다(Bharucha et al. (2009) Clin Endocrinol (Oxf) 70(3): 415-420; Chang et al. (2012) Diabetes Care 35(12): 2594-2596). 이 지연은 위 배출이 느려졌기 때문이다. 당뇨병 대상체에서 지연된 위 배출을 설명하기 위해 위장과 소장 사이의 이동 지연을 이 실시예의 모델에 추가하였다. 약물 및 호르몬(예를 들어, GLP-1)은 위장의 미주신경 긴장도에 영향을 줄 수 있으며, 이는 기계적 혼합 및/또는 연동 운동을 감소시키고, 위 배출도 느리게 한다(Jelsing et al. (2012) Diabetes Obes Metab 14(6): 531-538; Little et al. (2006) J Clin Endocrinol Metab 91(5): 1916-1923; Nauck et al. (2011) Diabetes 60(5): 1561-1565; van Can et al. (2013) Int J Obes (Lond) 38(6): 784-93).

본 연구의 한 가지 목적은 GLP-1 관련 부작용, 즉 오심 및 구토를 예방하는 것이었다(Lean et al. (2014) Int J Obes (Lond) 38(5): 689-697). 위 배출 측정값은 낮은 위 배출률과 상관관계가 있는, 오심 및 구토와 같은 부작용의 예측을 제공하였다. 따라서, 이 모델에서의 위장 부작용에 대한 마커는 위 배출률의 합이었다.

질환의 여러 단계에서 건강한 2형 당뇨병 환자를 대표하는 모델 플랫폼에서 서로 다른 가상의 환자를 구현하였다. 또한, 가상 환자들은 다양한 정도의 비만과 이상지질혈증을 포함했다. 가상 환자들은 클리닉에서 관찰된 질환의 심각성 및 병태생리학 및 표현형 변이성의 다양성을 나타냈다.

여러 치료법, 즉 GLP-1RA/FGF21 융합 단백질, 리라글루티드, FGF21 유사체 LY2405319, 메트포르민, 아토르바스타틴, 시타글립틴, 및 인간 인슐린을 모델에서 구현하였다. 이들 치료법은 시뮬레이션에서 켜거나 끌 수 있었다. 가상 환자는 GLP-1RA/FGF21 융합 단백질을 투여할 때 메트포르민과 아토르바스타틴의 배경 상에 있다고 가정했다.

가상 GLP-1RA/FGF21 융합 단백질을 이 실시예에 기재한 모델에서 구현하였다. 융합 단백질은 FGF21 및 GLP-1 효능제 활성을 둘 다 포함하고, FGF21 및 GLP-1 수용체 효능제와 동일한 효과를 가졌다. 가상 융합 단백질의 약력학 프로파일은 두라글루티드와 유사하다고 가정되었다(Geiser et al. (2016) Clin Pharmacokinet 55(5): 625-34).

이 모델을 수많은 데이터 세트와 비교하여 검증하였다. 시뮬레이션 결과는 관련 데이터 및 지식, 예를 들어, 문헌[Hellerstein et al. (1997) J Clin Invest 100(5): 1305-1319; Muscelli et al. (2008) Diabetes 57(5): 1340-1348]과 정성적으로 일치했다. 모델은 관련된 정량적 테스트 데이터, 예를 들어, 다음의 문헌과 일치했다: Aschner et al. (2006) Diabetes Care 29(12): 2632-2637; Dalla Man, Caumo et al. (2005) Am J Physiol Endocrinol Metab 289(5): E909-914; Dalla Man et al. (2005) Diabetes 54(11): 3265-3273; Fiallo-Scharer (2005) J Clin Endocrinol Metab 90(6): 3387-3391; Hahn et al. (2011) Theor Biol Med Model 8: 12; Herman et al. (2005) Clin Pharmacol Ther 78(6): 675-688; Herman et al. (2006) J Clin Pharmacol 46(8): 876-886 및 J Clin Endocrinol Metab 91(11): 4612-4619; Hojlund et al. (2001) Am J Physiol Endocrinol Metab 280(1): E50-58; Monauni et al. (2000) Diabetes 49(6): 926-935; Nauck et al. (2009) Diabetes Care 32(1): 84-90; Nauck et al. (1993) J Clin Invest 91(1): 301-307; Nauck et al. (2004) Regul Pept 122(3): 209-217; Tzamaloukas et al. (1989) West J Med 150(4): 415-419; Sikaris (2009) J Diabetes Sci Technol 3(3): 429-438; Vicini and Cobelli (2001) Am J Physiol Endocrinol Metab 280(1): E179-186; Vollmer et al. (2008) Diabetes 57(3): 678-687.

기존의 치료법을, FGF21 유사체 및 GLP-1 수용체 효능제를 포함하는, 직접 비교를 위한 모델에서 구현했다. FGF21 유사체의 효과를, 예를 들어, 문헌[Gaich et al. (2013) Cell Metab 18(3): 333-340]의 임상 데이터로 검증했다. GLP-1 수용체 효능제인 리라글루티드는 표적에 대한 직접적인 경쟁자였으며, 이의 구현을 다양한 임상 데이터, 예를 들어 다음의 문헌에 기재된 데이터와 비교하였다: Jacobsen et al. (2009) Br J Clin Pharmacol 68(6): 898-905; Elbrond et al. (2002) Diabetes Care 25(8): 1398-1404; Chang et al. (2003) Diabetes 52(7): 1786-1791; Kolterman et al. (2003) J Clin Endocrinol Metab 88(7): 3082-3089; Degn et al. (2004) Diabetes 53(5): 1187-1194; Kolterman et al. (2005) Am J Health Syst Pharm 62(2): 173-181; Vilsboll et al. (2008) Diabet Med 25(2): 152-156; Buse et al. (2009) Lancet 374(9683): 39-47; Jelsing et al. (2012) Diabetes Obes Metab 14(6): 531-538; Hermansen et al. (2013) Diabetes Obes Metab 15(11): 1040-1048; Suzuki et al. (2013) Intern Med 52(10): 1029-1034; van Can et al. (2013) Int J Obes (Lond) 38(6): 784-93); Zinman et al. (2009) Diabetes Care 32(7): 1224-1230; Russell-Jones et al. (2009) Diabetologia 52(10): 2046-2055; Pratley et al. (2011) Int J Clin Pract 65(4): 397-407; Nauck et al. (2013) Diabetes Obes Metab 15(3): 204-212; Flint et al. (2011) Adv Ther 28(3): 213-226; Kapitza et al. (2011) Adv Ther 28(8): 650-660; Astrup et al. (2012) Int J Obes (Lond) 36(6): 843-854.

모델 플랫폼으로 다양한 활성 비율을 갖는 가상 GLP-1RA/FGF21 융합 단백질의 유익한 효과 및 부작용에 대한 시뮬레이션이 가능했다. 효과적인 FGF21-매개된 EC50 값은 문헌[Gaich et al. (2013) Cell Metab 18: 333-340]으로부터 유도된 값들에 대해 설정된 상수였다. 효과적인 GLP-1-매개된 EC50 값은 내인성 GLP-1에 비해 1씩 증가하여 2 내지 600배 감소했다(표 1).

GLP-1R 효능제/FGF21 융합 단백질 약력학(EC50 값).

효능 비율 ^*	유효 GLP-1-매개 EC50 값				유효 FGF21- 매개 EC50 값 ^**
효능 비율 ^*	말초 글루코스 흡수	인슐린 방출	위 배출	음식물 섭취	유효 FGF21- 매개 EC50 값 ^**
1	35 pM	20 pM	50 pM	80 pM	3547 pM
100	3500 pM	2000 pM	5000 pM	8000 pM	3547 pM

^* 내생성 GLP-1 대비

^** FGF21 EC50 값을 문헌[Gaich et al. (2013) Cell Metab 18(3): 333-340]에 따라 최대 효과의 절반을 가정하여 설정했다.

각각의 가상 융합 단백질에 대해, 관련 약력학 평가변수, 즉 HbA1c, 트리글리세리드, 지방산, 비-HDL 콜레스테롤 및 지방량에 대해 노출-반응 관계를 시뮬레이션하였다. GLP-1-매개된 부작용에 대한 마커로서 위장 배출 속도를 사용하였다. GLP-1RA/FGF21 융합 단백질을 가진 평균 비만 이상지질혈증 2형 당뇨병 가상 환자의 52주 치료를 광범위한 용량 범위에 대해 시뮬레이션하였다. 52주간의 치료 후 모든 관련 약력학 평가변수는 정상 상태에 도달할 것으로 예상된다. 각 평가변수에 대해 절반의 최대 유효 농도(EC50 값)가 노출-반응 곡선으로부터 결정되었다. EC50 값은 특히 주요 GLP-1-매개된 평가변수인 HbA1c와 위 배출 속도에 대한 활성 비율에 따라 다양했다. 도 1은 GLP-1 감쇠 지수에 따른 EC50 값을 도시한다. 증가된 GLP-1 감쇠 지수는 GLP-1R 효능제 활성의 감소를 나타냈다.

이 절차는 관련 활성 비율에 대한 확인을 가능하게 하며, 이에 대한 부작용은 약력학 효과를 매개한 혈장 수준과 비교하여 더 높은 혈장 수준에서 관찰되었다. 9보다 큰 GLP-1 감쇠 지수의 경우, GLP-1-매개된 위장 부작용의 EC50은 약력학 효과의 EC50보다 컸다. 따라서, 약력학 효과를 달성하는 데 필요한 수준보다 더 높은 혈장 수준에서 위장 부작용이 발생했다. GLP-1-매개된 위장 부작용을 피하면서, 모든 바람직한 약력학 효과를 제공하는 용량을 설명하는 것이 가능했다.

위 배출 속도에 대한 최대 EC50 값은 감쇠 계수 531에 도달했다. 부작용과 평균 약력학 효과 사이의 최대 거리는 감쇠 계수 482에 도달하였다(도 2). 따라서, 1:482를 넘어서는 활성 비율은 적절하지 않았다. 약력학 효과(HbA1c)의 최대치와 부작용 사이의 최대 거리는 319였다. FGF21-(지질) 및 GLP-1-매개된 효과(HbA1c)의 확산으로 정규화된, 약력학 효과(HbA1c)의 최대치 및 부작용 사이의 최대 거리는 121이었다.

1:10 내지 1:482의 효능 비율을 갖는 GLP-1RA/FGF21 융합 단백질은 지질 프로파일, 체중 및 글루코오스 대사를 개선시키는데 가장 유익했으며, 위 배출 반응에 기반한 유의미한 부작용을 유발하지 않을 것으로 예상되었다. 더 낮은 효능 비율은 예상되는 위 배출의 강력한 억제 및 부작용 가능성에 기반하여 좋은 후보가 아닐 가능성이 높았다. 더 높은 효능 비율은 충분히 효과적이지 않고 따라서 경쟁력이 없는 것으로 생각되었다.

당업계에 공지된 GLP-1 수용체 효능제 및 FGF21 작용제로의 12주 처치 후에 HbA1c 수준의 주로 GLP-1-매개 파라미터가 임상적으로 정상 상태에 도달하기 때문에, GLP-1RA/FGF21 융합 단백질을 이용한 평균 비만 이상지질혈증 2형 당뇨병 가상 환자의 12주 치료를 넓은 용량 범위에 대해 시뮬레이션하였다.

도 3은 12주 시뮬레이션 기간에 걸쳐 GLP-1 감쇠 지수 대비 획득된 EC50 값을 도시한다. 18보다 큰 GLP-1 감쇠 지수의 경우, GLP-1-매개된 위장 부작용의 EC50은 약력학 효과의 EC50보다 컸다. 위장 배출 속도에 대한 최대 EC50 값은 감쇠 지수 501에 도달했다. 부작용과 평균 약력학 효과 사이의 최대 거리는 감쇠 지수 469에 도달했다(도 4). 약력학 효과(HbA1c)의 최대치와 부작용 사이의 최대 거리는 313이었다. FGF21-(지질) 및 GLP-1-매개 효과(HbA1c)의 확산에 의해 정규화된 약력학 효과(HbA1c)의 최대치 및 부작용 사이의 최대 거리는 123이었다.

다양한 활성 비율을 갖는 GLP-1RA/FGF21 융합 단백질의 부작용 가능성 및 효능을 기재된 시스템 약리학적 접근법을 사용하여 조사하였다. 짐작으로 계산된 이상적인 효능 비율을 가진 융합 단백질이 확인되었으며, 위장 배출 반응에 기반하여 유의한 GLP-1RA 연관 부작용을 일으키지 않으면서 지질 프로파일, 체중 및 혈당 제어를 개선시키는 데 유익한 것으로 예측되었다. 선택된 모델-정보제공 효능 비율을 갖는 화합물은 양호한 효능 대 위험 프로파일을 제공할 것으로 예측되었다.

실시예 2: HEK-293, CHO 및 이.콜라이( E.coli ) 세포에서 동종이량체 GLP-1RA/FGF21 융합 단백질의 발현 및 단리된 GLP-1R 효능제 펩티드의 화학적 합성

GLP-1RA/FGF21 Fc 융합 단백질을 HEK-293 또는 CHO 세포에서 일시적인 형질감염으로 생산했다. 융합 단백질의 DNA 서열은 IL2 신호 서열(서열번호: 246)에 대해 N-말단에 융합되었고 이어서 히스티딘 풍부 서열(His-tag) 및 TEV 프로테아제-절단 부위(서열번호: 247 또는 248)가 뒤따랐다. 신호 서열은 원하는 단백질을 배양 배지로 분비하는 데 필요했다. 고정화된 금속-이온 친화성 크로마토그래피(IMAC)(cOmplete His-Tag Purification Column™, Roche)를 사용하여 배양 상청액으로부터 단백질을 정제했다. IMAC-칼럼으로부터의 용리 후, 담배 식각 바이러스(TEV; Tobacco Etch Virus) 프로테아제를 첨가하여 N-말단 His-태그를 선택적으로 절단했다. His-태그 절단 후, 절단 반응 용액을 IMAC-컬럼(cOmplete His-Tag Purification Column™, Roche)에 2회 통과시켜 (His-태그-프리) 통과 분획을 수집했다. 단백질을 단백질 A 친화성 크로마토그래피(rProtein A Sepharose, GE Healthcare) 및 인산염 완충 식염수(PBS, Gibco)를 전개 완충액으로 사용하는 겔 여과 컬럼을 사용하여 추가로 정제했다. 원하는 단백질을 함유하는 분획을 수집하고, 모으고, 농축하고, 추가 사용 전까지 -80℃에서 보관했다.

서열번호: 252의 FGF21 단백질(추가적인 N-말단 Gly를 갖는 성숙한 인간 야생형 FGF21; 본 명세서에서 G-FGF21로 지칭됨)은 이. 콜라이(E. coli)에서 발현되었다. FGF21 단백질의 DNA 서열은 히스티딘이 풍부한 서열(His-tag) 및 TEV 또는 SUMO 프로테아제-절단 부위(서열번호: 248 또는 249)에 N-말단 융합되었다. 고정화 금속 이온 친화성 크로마토그래피(IMAC)(HisTrap HP, GE Healthcare)를 사용하여 원하는 단백질을 정제한 후 TEV 또는 SUMO 프로테아제를 첨가하여 N-말단 His-태그를 절단했다. His-태그 절단 후, 절단 반응 용액을 이온 교환 컬럼(Source 15, GE Healthcare)을 사용하여 정제한 후, 인산염 완충 식염수(PBS, Gibco)를 전개 완충액으로 사용하는 겔 여과 컬럼(Superdex 75, GE Healthcare)을 사용하여 정제했다. 원하는 단백질을 포함하는 분획을 수집하고, 모으고, 농축하고, 추가 사용 전까지 -80℃에서 보관했다.

대안적인 접근법에서, 융합 단백질은 이. 콜라이(E. coli) 봉입체에서의 발현에 이어 트리스-완충된 구아니디늄 클로라이드 용액에서 봉입체를 언폴딩시키고 카오트로픽 염 없이 완충액에서 희석하여 리폴딩하여 폴딩된 융합 단백질이 얻어지는 리폴딩 단계에 의해 생성되었다. 단백질 A 친화성 크로마토그래피(MabSelect SuRe, GE Healthcare)를 사용하여 융합 단백질을 정제한 후 이어서 TEV 프로테아제를 첨가하여 N-말단 전서열을 절단했다. 절단 반응 용액은 음이온 교환 컬럼(POROS 50 HQ, ThermoFisher)을 사용하여 정제했다. 원하는 단백질을 포함하는 분획을 수집하고 모았다. 최종 완충액 조건 및 단백질 농도를 PBS(Gibco)를 사용하는 한외여과/정용여과 단계로 확립했다. 샘플을 추가 사용 전까지 -80℃에서 보관했다.

융합 단백질을 재조합 방법(상기 참조)으로 생산한 반면, 분리된 펩티드성 GLP-1R 효능제를 화학적으로 합성했다.

보다 구체적으로, 다음 수동 합성 절차를 사용하여 펩티드를 합성했다:

건조된 Rink 아미드 MBHA 수지 0.3 g(0.66 mmol/g)을 폴리프로필렌 필터가 장착된 폴리에틸렌 용기에 넣었다. 수지를 DCM(15 ㎖)에서 1시간 동안 및 DMF(15 ㎖)에서 1시간 동안 팽윤시켰다. 수지의 Fmoc 기를 20%(v/v) 피페리딘/DMF 용액으로 5분 및 15분 동안 두 번 처리하여 탈보호시켰다. 수지를 DMF/DCM/DMF(각각 6:6:6회)로 세척했다. Kaiser 테스트(정량적 방법)를 사용하여 고체 지지체에서 Fmoc가 제거된 것을 확인하였다. 무수 DMF 중의 C-말단 Fmoc-아미노산(수지 로딩에 상응하는 5 당량 과량)을 탈보호된 수지에 첨가하고, 다음 Fmoc-아미노산의 커플링을 DMF 중의 5 당량 과량의 DIC 및 HOBT로 개시했다. 반응 혼합물에서 각 반응물의 농도는 대략 0.4 M이었다. 혼합물을 실온에서 2시간 동안 회전자에서 회전시켰다. 수지를 여과하고 DMF/DCM/DMF(각각 6:6:6회)로 세척했다. 커플링 완료 시 펩티드 수지 분취액에 대해 수행된 Kaiser 테스트는 음성이었다(수지는 색상을 띠지 않았음). 첫 번째 아미노산 부착 후, 수지에 미반응 아미노기가 있는 경우, 아세트산 무수물/피리딘/DCM(1:8:8)을 사용하여 20분 동안 캡핑하여 서열의 결실을 방지했다. 캡핑 후, 수지를 DCM/DMF/DCM/DMF(각각 6/6/6/6회)로 세척했다. 펩티딜 수지에 부착된 C-말단 아미노산의 Fmoc 기를 20%(v/v) 피페리딘/DMF 용액으로 5분 및 15분 동안 두 번 처리하여 탈보호시켰다. 수지를 DMF/DCM/DMF(각각 6:6:6회)로 세척했다. Fmoc-탈보호 완료 시 펩티드 수지 분취액에 대해 수행된 Kaiser 테스트는 양성이었다.

Rink 아미드 MBHA 수지 상의 표적 서열의 나머지 아미노산을 DMF에서 수지 부하에 해당하는 5 당량 과량을 사용하여 Fmoc AA/DIC/HOBt 방법을 사용하여 순차적으로 결합시켰다. 반응 혼합물에서 각 반응물의 농도는 대략 0.4 M이었다. 혼합물을 실온에서 2시간 동안 회전자에서 회전시켰다. 수지를 여과하고 DMF/DCM/DMF(각각 6:6:6회)로 세척했다. 각각의 커플링 단계 및 Fmoc 탈보호 단계 후, Kaiser 테스트를 수행하여 반응의 완결성을 확인했다.

선형 서열이 완성된 후, 라이신의 ε-아미노기를 분지점 또는 변형점으로 사용하고 DMF에서 2.5% 하이드라진 수화물을 사용하여 15분 동안 2회 탈보호하고 DMF/DCM/DMF(각각 6:6:6 시간)로 세척했다. DMF에서 Fmoc-Glu(OH)-OtBu를 사용하여 DIC/HOBt 방법(수지 로딩에 대해 5 당량 과량 사용)을 사용하여 글루탐산의 γ-카복실 말단을 Lys의 ε-아미노기에 부착시켰다. 혼합물을 실온에서 2시간 동안 회전자에서 회전시켰다. 수지를 여과하고 DMF/DCM/DMF(각각 6×30mL)로 세척했다. 글루탐산의 Fmoc 기를 20%(v/v) 피페리딘/DMF 용액으로 5분 및 15분(각각 25 mL) 동안 두 번 처리하여 탈보호시켰다. 수지를 DMF/DCM/DMF(각각 6:6:6회)로 세척했다. Fmoc-탈보호 완료 시 펩티드 수지 분취액에 대한 Kaiser 테스트는 양성이었다.

측쇄 분지가 또한 하나 이상의 γ-글루탐산을 포함하는 경우, 제2의 Fmoc-Glu(OH)-OtBu를 사용하여 DMF에서 DIC/HOBt 방법(수지 로딩에 대해 5 당량 과량)을 사용하여 γ-글루탐산의 유리 아미노산 기에 부착시켰다. 혼합물을 실온에서 2시간 동안 회전자에서 회전시켰다. 수지를 여과하고 DMF/DCM/DMF(각각 6×30mL)로 세척하였다. γ-글루탐산의 Fmoc 기를 20%(v/v) 피페리딘/DMF 용액으로 5분 및 15분(25 mL) 동안 두 번 처리하여 탈보호시켰다. 수지를 DMF/DCM/DMF(각각 6:6:6회)로 세척했다. Fmoc-탈보호 완료 시 펩티드 수지 분취액에 대해 수행된 Kaiser 테스트는 양성이었다.

수지로부터 펩티드의 최종 절단:

수동 합성에 의해 합성된 펩티딜 수지를 DCM(6×10 mL), MeOH(6×10 mL) 및 에테르(6×10mL)로 세척하고 진공 데시케이터에서 밤새 건조시켰다. 고체 지지체로부터 펩티드의 절단은 시약 칵테일(80% TFA/5% 티오아니솔/5% 페놀/2.5% EDT/2.5% DMS/5% DCM)로 펩티드-수지를 실온에서 3시간 동안 처리함으로써 달성되었다. 절단 혼합물을 여과에 의해 수집하고 수지를 TFA(2 mL) 및 DCM(2 × 5 ㎖)으로 세척했다. 과량의 TFA 및 DCM을 질소 하에서 소량으로 농축하고 소량의 DCM(5 내지 10 ㎖)을 잔류물에 첨가하고 질소 하에서 증발시켰다. 이 과정을 3 내지 4회 반복하여 대부분의 휘발성 불순물을 제거했다. 잔류물을 0℃까지 냉각하고 무수 에테르를 첨가하여 펩티드를 침전시켰다. 침전된 펩티드를 원심분리하고 상청액 에테르를 제거하고 신선한 에테르를 펩티드에 첨가하고 재원심분리했다. 미정제 샘플을 분취용 HPLC로 정제하고 동결건조시켰다. 펩티드의 정체는 LCMS로 확인했다.

실시예 3: CHO 세포에서 인간 FGF21 수용체 효능에 대한 시험관내 세포 분석(세포내 웨스턴)

G-FGF21(서열번호: 252) 및 본 발명의 융합 단백질의 세포 시험관내 효능은 특이적이고 매우 민감한 세포내 웨스턴(ICW) 분석을 사용하여 측정했다. ICW 분석은 일반적으로 마이크로플레이트 형식을 사용하여 수행되는 면역세포화학적 분석이다. 인간 베타-클로토(KLB)와 함께 인간 FGFR1c를 안정적으로 발현하는 CHO Flp-In 세포(Invitrogen, 독일 다름슈타트 소재)를 FGF21 수용체 자가인산화 ICW 분석에 사용했다(Aguilar et al. (2010) PLoS ONE 5(4): e9965). 수용체 자가인산화 수준 또는 MAP 키나제 ERK1/2의 하류 활성화를 결정하기 위해, 2×10⁴개 세포/웰을 96-웰 플레이트에 시딩하고 48시간 동안 성장시켰다. 세포를 3 내지 4시간 동안 무혈청 배지인 GlutaMAX가 있는 햄(Ham)의 F-12 Nutrient Mix(Gibco, 독일 다름슈타트 소재)에서 혈청 고갈시켰다. 이어서 세포를 증가하는 농도의 G-FGF21(서열번호: 252) 또는 지시된 융합 단백질로 37℃에서 5분 동안 처리했다. 인큐베이션 후, 배지를 버리고 세포를 20분 동안 새로 준비한 3.7% 파라-포름알데히드에 고정시켰다. 세포를 PBS 중 0.1% Triton-X-100으로 20분 동안 투과시켰다. 실온에서 2시간 동안 Odyssey 차단 완충액(LICOR, 독일 바트홈부르크 소재)을 이용하여 차단을 수행했다. 1차 항체로서, 항-pFGFR Tyr653/654(New England Biolabs, 독일 푸랑크푸르트 소재) 또는 항-pERK Phospho-p44/42 MAP Kinase Thr202/Tyr204(Cell Signaling)를 첨가하고 4℃에서 밤새 인큐베이션했다. 1차 항체의 인큐베이션 후, 세포를 PBS + 0.1% Tween20으로 세척했다. 그런 다음 세포를 실온에서 1시간 동안 2차 항-마우스 800CW 항체(LICOR, 독일 바트홈부르크 소재)와 함께 인큐베이션했다. 이어서, 세포를 다시 PBS + 0.1% Tween20으로 세척했다. 적외선 염료 신호를 Odyssey 이미저(LICOR, 독일 바트홈부르크 소재)로 정량화했다. TO-PRO3 염료(Invitrogen, 독일 카를스루에 소재)로 DNA를 정량화하여 결과를 정규화했다. 데이터는 임의 단위(AU)로 얻었고 EC50 값은 용량-반응 곡선에서 얻었다(표 2 및 3에 요약됨). 도 5는 인간 FGFR1c와 KLB를 과발현하는 CHO 세포를 이용한 ICW의 결과를 나타낸다.

CHO 세포에서 ICW pFGFR을 통해 측정된 G-FGF21(서열번호: 252) 및 GLP-1RA/FGF21 Fc 융합 단백질의 EC50 값.

서열번호	pFGFR ICW EC50(nmol/L)
252	4.49
1	38.61
2	30.57
3	22.72
4	36.35
5	20.38
6	19.73
7	27.85
8	25.39
19	34.31
20	42.86
23	54.56
24	25.29
39	13.85
44	29.99
57	25.83
71	13.57
83	16.60
209	66.29

CHO 세포에서 ICW pERK를 통해 측정된 G-FGF21(서열번호: 252) 및 GLP-1RA/FGF21 Fc 융합 단백질의 EC50 값.

서열번호	pERK ICW EC50 (nmol/L)
252	0.17
1	6.72
2	6.94
3	6.07
4	8.61
5	6.84
6	9.86
7	5.96
8	6.75
19	43.75
20	10.40
23	8.60
24	8.39
39	4.28
44	5.40
57	6.86
71	6.19
83	2.44
209	27.93

실시예 4: 인간 글루카곤-유사-펩티드 1(GLP-1) 수용체 효능에 대한 시험관내 세포 분석

인간 글루카곤-유사 펩티드-1(GLP-1) 수용체에 대한 화합물의 효능작용을 인간 GLP-1 수용체를 안정적으로 발현하는 HEK-293 세포주에서 cAMP 반응을 측정하는 기능적 분석으로 결정했다.

재조합 HEK-293 세포를 배지(10% FBS가 포함된 DMEM)에서 거의 컨플루언시(confluence)에 도달할 때까지 37℃에 배치된 T175 배양 플라스크에서 성장시켰고, 10% DMSO를 포함하는 세포 배양 배지가 들어 있는 2 mL 바이알에 1 내지 5×10⁷개 세포/mL 농도로 수집했다. 각 바이알에는 세포 현탁액 1.8 mL을 담았다. 바이알을 이소프로판올 챔버에서 -80℃까지 천천히 동결시킨 다음, 장기 보관을 위해 액체 질소로 옮겼다.

사용하기 전에 냉동 세포를 37℃에서 빠르게 해동하고, 20 ㎖ 세포 완충액(1× HBSS; 20 mM HEPES, 0.1% BSA)으로 세척하고 900 rpm에서 5분 동안 원심분리했다. 세포를 분석 완충액(세포 완충액 + 2 mM IBMX)에 재현탁하고 1×10⁶개 세포/mL의 세포 밀도로 조정했다. 측정을 위해, 384-웰 플레이트의 웰에 5 ㎕ 세포 현탁액(최종 5×10³개 세포/웰)과 5 ㎕의 테스트 화합물을 첨가하고 실온에서 30분 동안 인큐베이션하였다. Bachem(스위스 부벤도르프 소재, H-6795)의 인간 GLP-1(7-36) 아미드(서열번호: 260)를 대조군으로 삼았다. 세포의 cAMP 함량을 균질한 시간 분해 형광(Homogenous Time Resolved Fluorescence, HTRF)에 기반한 Cisbio Corp.(카탈로그 번호 62AM4PEC)의 키트를 사용하여 결정했다. 용해 완충액(키트 구성 요소)에 희석된 HTRF 시약을 첨가한 후 플레이트를 1시간 동안 배양한 후 665/620 nm에서 형광 비율을 측정했다. 최대 반응의 50% 활성화(EC50)를 유발하는 농도를 결정함으로써 효능제의 시험관내 효능을 정량화했다.

결과는 표 4에 요약되어 있으며 용량-반응 곡선은 도 6에 나타나 있다.

HEK-293 세포에서 HTRF cAMP 분석을 통해 측정된 인간 GLP-1(7-36)(서열번호: 260), GLP-1RA/FGF21 Fc 융합 단백질 및 여러 단일 GLP-1R 효능제 펩티드의 EC50 값.

서열번호	HTRF cAMP EC50 (pmol/L)
서열번호	인간 GLP-1R	마우스 GLP-1R	원숭이 GLP-1R
260	0.77	0.62	1.12
1	218.76	2.80	161.07
2	193.72	2.93	164.36
3	211.94	97.21	278.82
4	313.33	5.29	261.98
5	125.01	96.46	195.69
6	383.35	6.45	347.21
7	130.91	68.11	190.20
8	152.24	77.14	217.09
18	9.90	2.09	10.18
19	11.20	2.16	10.95
20	9.49	1.97	9.86
21	93.80	4.19	78.68
22	85.58	3.88	73.93
23	78.72	3.32	70.72
24	48.83	2.66	43.54
25	45.94	101.49	81.30
26	40.08	95.33	73.30
27	37.53	90.96	75.10
28	32.85	106.99	68.70
29	37.67	113.45	64.00
30	41.96	125.49	73.30
31	32.31	113.47	62.80
39	8.50	1.16	12.30
40	46.06	39.02	50.40
42	18.07	43.21	22.20
43	13.69	31.48	17.40
44	125.83	325.07	174.00
45	48.20	492.12	60.42
46	8.47	17.85	11.40
47	16.99	6.64	35.60
48	35.70	10.07	60.60
49	23.37	6.65	42.20
50	20.51	7.87	38.20
51	26.84	7.58	51.10
52	25.60	7.04	46.00
53	28.37	128.18	25.03
54	107.04	118.79	97.40
55	261.38	595.82	156.56
56	15.02	66.73	11.48
57	21.12	19.29	15.70
58	9.38	7.19	5.76
59	13.64	13.50	10.31
60	22.52	11.72	13.02
61	68.26	42.99	40.20
62	20.32	13.38	12.93
63	95.38	54.34	52.60
64	9.09	6.08	7.47
65	16.49	6.63	10.17
66	33.77	11.02	31.42
67	36.52	10.23	21.65
68	16.66	9.42	10.80
69	15.30	17.28	14.69
70	41.39	83.11	38.80
71	27.79	53.55	26.61
72	20.37	77.53	25.04
74	13.47	18.34	13.70
76	39.21	189.87	40.32
78	50.98	323.16	52.52
79	243.25	2512.19	295.89
80	48.63	64.39	42.55
81	49.87	67.40	49.36
82	90.13	72.47	109.18
83	29.30	55.99	28.11
84	38.20	n.d.	n.d.
88	33.03	n.d.	n.d.
89	45.29	n.d.	n.d.
90	336.00	n.d.	n.d.
92	58.86	n.d.	n.d.
93	48.35	n.d.	n.d.
94	66.49	n.d.	n.d.
95	18.49	n.d.	n.d.
96	43.99	n.d.	n.d.
97	40.39	n.d.	n.d.
100	15.01	n.d.	n.d.
101	83.50	n.d.	n.d.
102	169.50	n.d.	n.d.
105	8.12	n.d.	n.d.
106	9.66	n.d.	n.d.
107	186.50	n.d.	n.d.
108	326.00	n.d.	n.d.
109	278.00	n.d.	n.d.
112	7.23	n.d.	n.d.
113	158.50	n.d.	n.d.
115	92.20	n.d.	n.d.
116	10.61	n.d.	n.d.
118	18.27	n.d.	n.d.
120	10.17	n.d.	n.d.
121	11.87	n.d.	n.d.
122	14.53	n.d.	n.d.
123	12.74	n.d.	n.d.
124	10.58	n.d.	n.d.
126	8.51	n.d.	n.d.
127	10.27	n.d.	n.d.
128	9.83	n.d.	n.d.
129	12.30	n.d.	n.d.
130	7.38	n.d.	n.d.
132	8.48	n.d.	n.d.
133	13.44	n.d.	n.d.
134	17.34	n.d.	n.d.
135	11.49	n.d.	n.d.
136	11.84	n.d.	n.d.
139	7.35	n.d.	n.d.
142	12.89	n.d.	n.d.
143	14.20	n.d.	n.d.
144	16.22	n.d.	n.d.
145	7.63	n.d.	n.d.
146	12.25	n.d.	n.d.
147	10.11	n.d.	n.d.
148	8.48	n.d.	n.d.
150	11.53	n.d.	n.d.
151	8.66	n.d.	n.d.
152	9.43	n.d.	n.d.
153	9.98	n.d.	n.d.
155	11.02	n.d.	n.d.
156	9.22	n.d.	n.d.
157	12.08	n.d.	n.d.
158	8.70	n.d.	n.d.
161	252.21	n.d.	n.d.
162	270.04	n.d.	n.d.
163	374.50	n.d.	n.d.
164	102.76	87.97	141.14
165	173.00	n.d.	n.d.
166	159.50	n.d.	n.d.
167	309.50	n.d.	n.d.
168	46.10	n.d.	n.d.
169	59.60	n.d.	n.d.
170	233.50	n.d.	n.d.
171	266.50	n.d.	n.d.
172	253.50	n.d.	n.d.
174	76.95	n.d.	n.d.
175	90.85	n.d.	n.d.
176	71.75	n.d.	n.d.
177	48.65	n.d.	n.d.
180	405.50	n.d.	n.d.
181	137.00	n.d.	n.d.
182	123.00	n.d.	n.d.
183	73.80	n.d.	n.d.
184	216.00	n.d.	n.d.
185	13.85	n.d.	n.d.
186	123.85	n.d.	n.d.
187	67.44	67.47	63.20
188	59.65	70.96	63.70
190	152.41	479.17	238.78
192	102.27	98.00	148.81
193	108.18	71.30	151.49
194	127.68	129.00	139.93
195	74.51	56.60	71.84
196	75.28	31.70	126.80
197	68.32	48.00	101.65
198	86.54	65.10	86.91
199	163.23	153.00	231.19
200	73.11	46.20	110.64
201	100.55	69.80	98.56
202	100.50	71.70	127.68
203	96.88	89.20	101.69
204	102.74	65.70	93.49
205	130.74	127.00	113.32
206	107.18	93.70	150.82
207	146.88	128.00	188.80
208	169.64	127.95	254.61
209	164.10	118.21	231.66
211	58.80	151.66	68.55
212	113.42	286.97	153.33
216	151.60	346.64	262.81
217	7.62	5.39	n.d.
219	221.50	422.46	n.d.
220	95.55	110.49	n.d.
221	202.49	162.48	n.d.
222	327.48	200.50	n.d.
223	80.85	79.52	n.d.
224	226.96	250.98	n.d.
225	127.98	61.60	n.d.
226	64.09	43.53	n.d.
227	61.35	40.75	n.d.
228	49.19	30.10	n.d.
229	62.87	469.79	82.08
261	56.32	1.12	49.40
262	10.48	7.65	5.74
271	6.94	0.84	9.51
272	20.80	1.31	21.74
274	19.47	71.25	19.95
275	31.15	101.21	20.00
278	10.48	7.65	5.74
279	210.23	380.23	250.95
281	9.87	20.04	7.11
282	34.04	40.15	26.60
284	51.40	69.52	39.71
286	15.57	29.08	12.99
291	28.89	11.09	28.36
292	8.48	8.56	8.77
293	29.23	5.06	27.60
294	208.98	42.34	182.99
295	9.23	49.40	9.87
297	21.30	33.10	21.54
298	93.60	65.80	56.70
301	23.68	23.70	16.31

n.d.: 결정되지 않음

실시예 5: GLP-1RA/FGF21 Fc 융합 단백질의 구조 및 열 안정성 분석

UNit(Unchained Labs, 미국 캘리포니아주 소재)를 사용하여 GLP-1RA/FGF21 Fc 융합 단백질에 대해 구조적 안정성 및 응집 경향을 동시에 결정했다. UNit는 단백질 또는 폴리펩티드의 언폴딩을 검출하기 위한 단백질 또는 폴리펩티드의 고유 형광 분석과 응집 거동을 조사하기 위한 정적 광 산란(SLS) 측정을 결합한다.

pH 7.4의 인산염 완충액에 제형화된 5 mg/mL 농도의 융합 단백질에 대한 데이터를 획득했다. 각 샘플의 9 μL 부피를 UNi 모세관 홀더에 로딩하고 UNit에서 3회 분석했다. 온도를 0.3℃/분의 일정한 선형 속도로 20℃에서 95℃까지 증가시켰다. 용융 온도(Tm) 및 응집 시작 온도(Tagg)를 얻기 위해 적용된 온도에 대해 266 nm 레이저로 검출된 고유 형광 및 SLS 신호를 나타내는 BaryCentric Mean(BCM)을 플롯팅했다. UNit 분석 소프트웨어 v. 2.1을 사용하여 데이터를 분석했으며 표 5에 요약되어 있다.

또한, 일부 단백질의 경우 시차주사형광측정법(DSF 또는 ThermoFluor™) 분석을 모방하여 열안정성을 분석하기 위해 열 이동 분석을 적용했다(Ahmad S. et al. (2012) Protein Science 21: 433-446; Pantoliano et al. (2001) J. Biomol. Screen 6: 429-440, Niesen et al.(2007) Nat. Protoc. 2: 2212-21). 이 분석은 Sypro™ Orange(Life Technologies, 카탈로그 번호 S6651)와 같은 소수성 형광 염료가 단백질의 소수성 패치에 결합할 때 형광을 증가시킨다는 관찰을 기반으로 한다. 이러한 소수성 패치는 열을 가하면 언폴딩될 때 단백질에 노출되므로, 형광의 증가는 언폴딩 정도에 대한 척도, 따라서 단백질의 열안정성에 대한 척도로 사용될 수 있다.

PBS(Gibco)의 각 단백질 용액을 Sypro™Orange의 160× 용액(공급업체에서 제공한 5000× DMSO 스톡을 물에 희석)과 혼합하여 단백질을 테스트했다. PBS를 이용하여 샘플 부피를 20 μL로 조정했다. 통상적인 조건은 최종 혼합물에 0.8 mg/mL 단백질과 8× Sypro™ Orange를 포함했지만, 단백질 농도는 0.4 mg/mL에서 1.2 mg/mL 사이에서 다양할 수 있다. 샘플을 96-웰 PCR 플레이트(BioRad Semi-Skirt 96 흰색)에 분배하고 잠시 원심분리하여 기포를 제거했다. 플레이트를 BioRad iQ5 실시간 PCR 기기에 삽입하고 1℃/분의 램프 속도로 10℃에서 90℃까지 열 구배를 적용했다. 형광의 여기 및 정량화를 위해 485 nm 및 575 nm의 파장에 대한 필터를 선택했다. 데이터 처리에는 BioRad iQ5 Standard Edition 소프트웨어(v. 2.0.148.60623)를 사용했다. 온도에 대한 형광 강도 곡선에서, 변곡점을 용융 온도(Tm)에 대한 척도로 선택했다.

G-FGF21(서열번호: 252) 및 선택된 GLP-1RA/FGF21 Fc 융합 단백질의 용융 및 응집 온도.

서열번호	Tm (℃)	Tagg (℃)
252	43.1 *	n.d.
2	69.6	71.5
7	68.7	66.1
8	68.6	65.3
4	64.9	64.0
6	64.1	63.4
3	63.9	65.3
5	62.6	63.2
1	70.5	75.5

* DSF를 통해 생성된 데이터; n.d.: 결정되지 않음

실시예 6: 마우스 및 비인간 영장류에서의 약동학

GLP-1RA/FGF21 Fc 융합 단백질의 혈장 농도 및 약동학적 매개변수는, 세 가지 다른 방법을 사용하여 암컷 C57Bl/6 마우스 또는 수컷 사이노몰구스(Cynomolgus) 원숭이에게 용액으로 0.3 mg/kg의 단일 피하 투여 후 결정되었다. 투여 후 30분 내지 168시간 시점에서 혈액 샘플을 얻었다.

a.) GLP-1RA/FGF21 Fc 융합 단백질의 온전한 FGF21 부분의 정량화를 위한 생체분석 스크리닝 방법

ELISA 키트(F1231-K01, Eagle Biosciences, USA)를 사용하여 융합 단백질의 온전한 FGF21 부분에 대해 혈장 샘플을 분석했다. 분석에는 인간의 온전한 FGF21의 상이한 에피토프에 결합하는 2개의 선택된 항체로 2-부위(site) 샌드위치 기법을 활용했다. 항체 중 하나는 인간 FGF21의 N-말단 아미노산(aa) 29 내지 35에 특이적으로 결합하고 다른 항체는 인간 FGF21의 C-말단(aa 203 내지 209)에 특이적으로 결합한다. 분석 표준, 대조군 및 미지의 샘플을 항-인간 FGF21(aa 29 내지 35)-특이적 항체로 코팅된 마이크로플레이트의 웰에 직접 첨가했다. 동시에, 항-인간 FGF21(aa 203 내지 209)-특이적 항체가 컨주게이션된 양고추냉이 퍼옥시다제를 각 웰에 첨가했다. 첫 번째 인큐베이션 기간 후, 마이크로타이터 웰의 벽에 있는 항체는 샘플에서 인간 FGF21을 포획하였고 각 마이크로타이터 웰의 결합되지 않은 단백질을 씻어냈다. "항-FGF21 항체-인간의 온전한 FGF21-HRP 컨주게이션된 트레이서 항체"의 "샌드위치"를 형성하였다. 결합되지 않은 트레이서 항체를 후속 세척 단계에서 제거했다. 이 면역복합체의 검출을 위해, 웰을 기질 용액과 함께 일정 시간 동안 인큐베이션한 다음, 분광 광도계 마이크로플레이트 판독기에서 측정했다. 마이크로타이터 웰의 벽에서 인간의 온전한 FGF21에 결합된 면역복합체의 효소 활성은 샘플 내 온전한 FGF21의 양에 정비례했다.

b.) 온전한 전장 융합 단백질의 정량화를 위한 생체분석 스크리닝 방법

혈장 내 전장 GLP-1RA/FGF21 Fc 융합 단백질의 농도를 ELISA 방법을 사용하여 결정했다. 융합 단백질의 N-말단은 마우스 단클론 항-GLP1 항체(Mesoscale Discovery, MSD)에 의해 포획되었다. 실온(RT)에서 1시간 동안 150 ㎕의 Blocker A(MSD)로 플레이트를 차단하고 부드러운 진탕과 300 ㎕ 세척 완충액으로 3회 세척한 후, 50 μL의 희석된 혈장 샘플(표준 및 PK 연구 샘플)을 각 웰에 첨가하고 플레이트를 부드럽게 흔들면서 실온에서 1시간 동안 인큐베이션했다. 300 ㎕ 세척 완충액으로 3회 세척한 후 50 ㎕의 프라이머 검출 항체(C-말단 토끼 항-FGF21 항체, Pineda Antikoerper-Service, 독일 베를린 소재)를 각 웰에 첨가하고 플레이트를 RT에서 1시간 동안 인큐베이션했다. 300 ㎕ 세척 완충액으로 3회 세척한 후, PBS-Tween 0.05%(PBS-T)에 희석된 25 ㎕ 염소-항-토끼 항체(Sulfo-Tag 라벨링, MSD)를 각 웰에 첨가하고 플레이트를 실온(RT)에서 1시간 동안 인큐베이션했다. 300 ㎕ PBS-T로 3번 세척한 후 150 ㎕ 리드(read) 완충액을 웰에 첨가했다.

c.) GLP-1 FGF21 Fc 융합 단백질의 온전한 GLP-1 부분의 정량화를 위한 생체분석 스크리닝 방법

혈장 샘플을 GLP-1 ELISA 방법으로 융합 단백질의 온전한 GLP-1 부분에 대해 분석했다. ELISA 플레이트를 마우스 단클론 항-GLP-1 항체(Mesoscale Discovery, MSD)로 코팅했다. 실온(RT)에서 1시간 동안 부드럽게 진탕시키면서 150 ㎕의 Blocker A(MSD)로 차단하고 300 ㎕ PBS-T로 3회 세척한 후, 50 ㎕의 희석된 혈장 샘플(표준 및 PK 연구 샘플)을 각 웰에 첨가하고 플레이트를 부드럽게 진탕시키면서 실온에서 1시간 동안 인큐베이션했다. 300 ㎕ PBS-T로 3회 세척한 후, PBS-T(Sulfo-Tag labelled, MSD)에 희석된(1/3,333) 염소 항-인간 IgG 25 ㎕를 각 웰에 첨가하고 플레이트를 RT에서 1시간 동안 인큐베이션했다. 300 ㎕ PBS-T로 3번 세척한 후, 150 ㎕ 리드 완충액을 웰에 첨가했다.

비구획 모델 및 선형 사다리꼴 보간 계산을 사용하여 프로그램 WinNonlin 6.4로 약동학 매개변수를 계산했다. 결과는 표 6뿐만 아니라 도 7 및 8에 제시되어 있다. 결과는 새로운 GLP-1RA/FGF21 Fc 융합 단백질이 ng/mL 범위에서 최대 20 내지 40시간의 반감기로 혈장 수준을 유지했음을 나타낸다.

마우스 및 비인간 영장류에서 0.3 mg/kg의 피하 주사 후 선택된 GLP-1RA/FGF21 Fc 융합 단백질 및 G-FGF21(서열번호: 252)의 최종 반감기.

서열번호	분석	t _1/2 마우스 (h)	t _1/2 원숭이 (h)
2	온전한 FGF21 온전한 GLP-1 전장	27.6 27.8 16.1	42.5 33.4 23.5
7	온전한 FGF21 온전한 GLP-1 전장	14.2 n.d. 13.9	31.7 21.3 28.7
8	온전한 FGF21 온전한 GLP-1 전장	17.9 n.d. 13.3	33.6 23.7 27.6
252	온전한 FGF21 온전한 GLP-1 전장	0.7 n.d. n.d.	n.d. n.d. n.d.

n.d.: 결정되지 않음

실시예 7: 뮤린 모델에서의 생체내 효능

a.) 다회 투여 식이 유발 비만(DIO) 마우스

암컷 C57BL/6N Charles River 마우스를 물과 표준 또는 고지방 식이(ssniff 조정 지방 식이 E15797)에 자유롭게 접근할 수 있는 12시간 명/12시간 암 주기의 특정 무균 장벽 시설에 그룹별로 수용했다. 20주 동안 고지방식이를 사전 공급한 후, 마우스의 체중을 처리군(n = 8)으로 계층화하여, 각 그룹의 평균 체중이 비슷해지도록 했다. 표준 식단(chow)(ssniff R/M-H, V1534-0)에 자유롭게(ad-libitum) 접근할 수 있는 연령 일치 그룹을 표준 대조군으로 포함시켰다. 둘라글루티드 처치 그룹을 또한 대조군으로 포함시켰다. 처치를 시작하기 전에, 마우스에 비히클 용액을 피하(s.c.) 주사하고 3일 동안 체중을 재어 절차에 적응시켰다.

1) 급이한 암컷 DIO 마우스의 혈당에 대한 급성 영향: 비히클(인산염 완충액)의 첫 번째 투여(s.c.) 또는 GLP-1RA/FGF21 Fc 융합 단백질(인산염 완충액에 용해)의 첫 번째 투여 직전에, 각각, 초기 혈액 샘플을 채취했다. 투여 부피는 스톡 용액의 농도에 따라, 5 또는 10 mL/kg이었다. 동물들은 실험 동안 물과 상응하는 식단에 접근하였다. 혈당 수준은 t = 0시간, t = 1시간, t = 2시간, t = 3시간, t = 4시간, t = 6시간 및 t = 24시간에 측정했다(방법: Accu-Check 혈당계). 마취 없이 꼬리 절개를 통해 채혈을 실시했다.

2) 암컷 DIO 마우스의 체중에 대한 만성 효과: 마우스를 4주 동안 비히클 또는 테스트 화합물로 명기의 시작 시 아침에 매 8일마다 매주 1회 처치했다. 체중과 음식 섭취량을 매일 기록했다. 처치 시작 2일 전과 26일째에, 핵자기공명(NMR)으로 총 지방량을 측정했다.

체중과 음식 섭취에 대한 융합 단백질의 효과는 각각 도 9와 도 10에 나타나 있다. 서열번호: 8 또는 서열번호: 7의 융합 단백질로 처치한 동물은 연구가 종료될 때 비히클 또는 둘라글루티드로 처치한 동물보다 누적적으로 더 많은 음식을 섭취했지만, 비히클 또는 둘라글루티드로 처치한 동물보다 훨씬 더 많은 체중이 감소했다. 이는 서열번호: 7 및 서열번호: 8의 두 분자의 GLP-1 수용체 활성 대 FGF21 모방 활성의 균형을 명확하게 입증하며, 이는 체중 감소에 대한 이들의 효과가 구체화되기 위해 음식 섭취의 억제를 필요로 하지 않았기 때문이다.

b.) 급이한 암컷 당뇨병 db/db 마우스에서 다중 피하 용량의 혈당 저하 효과

동물, 연구 설계(투여 전 단계, 투여 단계), 약리학적 개입

암컷으로, 건강하고 날씬한(BKS.Cg-(lean)/OlaHsd 또는 BKS.Cg-Dock7(m)+/+ Lepr(db)J) 마우스 및 당뇨병에 걸리기 쉬운 비만 db/db(BKS.Cg-+Leprdb/+Leprdb/OlaHsd 또는 BKS.CG-m +/+ Lepr(db)/J) 마우스를 Envigo RMS Inc. 또는 Charles River Laboratories에서 주문했다. 모든 동물을 나무 조각 깔개가 있는 쇼박스 우리에 그룹별로 수용하고 투약 단계 전 대략 2 내지 3주 동안 적응시켰다.

마우스를 12시간 명/12시간 암 주기(명기 04:00 AM 내지 4:00 PM), 실내 온도 20 내지 26℃, 상대 습도 30 내지 70%를 포함하는 사육장 조건에서 수용했다. 모든 동물은 Greenfield 시의 수돗물과 Purina Fomolab Diet 5008에 자유롭게 접근하였다. 연구 시작 시 마우스는 대략 10 내지 12주령이었다.

투여 전 단계(15일)

꼬리 클립을 통해 9일째에 HbA1c 및 혈당 측정을 위해 혈액을 수집했다. 혈당 농도는 AlphaTRAK 혈당계 확장 범위(코드 29 스트립)를 사용하여 측정했다. 혈당계 측정은 임의의 다른 생활 활동 전에 수행했고 2회(duplicate) 수행했다. 값이 20 mg/dL(계산된 혈당계 값) 초과로 차이가 나면, 세 번째 값을 기록했다. 체질량 측정은 9일과 15일째에 수집했다. HbA1c와 체질량 값을 블록 무작위화에 사용했다. 블록 무작위화 결과에 따라 15일째에 동물을 처치 그룹(n = 8/그룹) 및 새로운 우리 및 우리 동료(n = 4마리 동물/케이지)에 할당했다. 날씬한 그룹은 연령에 맞는 건강한 참조 그룹으로 연구에 포함시켰다.

용량 제형 및 투여

투약 단계 1일, 8일, 15일, 22일 및 27일에 1회 비히클(멸균 PBS), 둘라글루티드, 서열번호: 8 또는 서열번호: 7을 5 ml/kg의 피하 주사 부피로 동물에 처치했다. 투약은 오전 10시에서 12시 사이에 완료했고, 각 개체의 가장 최근 기록된 체질량으로 조정되었다. 트룰리시티(Trulicity)(Dulaglutide Pen)를 포함한 주사 용액은 적절한 농도를 달성하기 위해 스톡 용액 또는 Pen 제형에 멸균 PBS를 첨가하여 준비했다.

투여 단계(36일)

1) 오전 급식한 동물의 혈당 농도: 동물은 실험 기간 동안 물과 사료에 무제한으로 접근하였다. 1, 2, 8, 9, 15, 16, 22, 23, 27, 28일째의 오전 10:00시와 12:00시 사이뿐만 아니라, 2, 9, 16, 23 및 28일째의 투여 후 24시에 임의의 다른 생활 활동 전에 혈당을 측정했다. 또한, 1일 및 22일째에는 투여 후 1, 2, 3, 4, 6 및 24시간에 채혈했다(도 11). 꼬리 클립을 통해 약 5 μL의 혈액을 수집하고 확장된 범위(코드 29 스트립)를 갖는 AlphaTRAK 혈당계를 사용하여 혈당 측정을 2회 수행했다. 값이 20 mg/dL(계산된 포도당 값) 초과로 차이가 나면, 세 번째 값을 기록했다. 곡선하면적(AUC)을 나타낸 바와 같이 각 개체 및 기간에 대해 사다리꼴 방법으로 계산하였다.

2) HbA1c 분석: 투여 전 단계의 9일째 및 투여 단계의 36일째에 꼬리 클립을 통해 혈액을 수집했다. 혈액을 5 μL 무첨가 마이크로 모세관에 수집했고 용혈물이 들어 있는 원심분리관에 즉시 넣었다. 용혈액과 혈액이 섞이도록 튜브를 격렬하게 진탕시킨 후 록커(rocker)에 위치시켜 혈액과 시약이 완전히 혼합되도록 했다. 연구 시작 시 및 연구 종료 후 혈장 HbA1c 수준은 도 12에 나타나 있다.

통계 분석: 데이터는 평균±SEM으로 표시된다. 통계 분석을 위해 당뇨병, 비만 db/db 비히클 마우스(n=8) 그룹과 당뇨병, 비만 db/db 테스트 항목 처치 마우스스(n=8) 그룹을 비교하는 일원 분산 분석(ANOVA) 및 다중 비교(Dunnett's Method)를 수행했다. 두 그룹의 평균 값의 차이가 0.05보다 크면 통계적으로 유의미한 차이가 있는 것으로 간주했다. 비-당뇨, 날씬한 비히클 그룹 데이터는 도 11 및 12에 도시되어 있으며 비-비만, 비-당뇨 상태에 대한 참조 데이터 세트 역할을 한다.

서열번호: 8 또는 서열번호: 7의 융합 단백질로 처치한 동물에서, 혈당 수준에 대한 저하 효과는 비히클 또는 둘라글루티드 처리된 동물에 비해 유의하게 월등했다(도 11). 서열번호: 8의 융합 단백질의 가장 높은 용량은 심지어 처치 22일째에 측정된 거의 전체 24시간 혈당 프로파일에 걸쳐 혈당 수준을 정상 비-당뇨병 동물 수준으로 감소시켰다. 또한, 서열번호: 8 또는 서열번호: 7의 융합 단백질로 처치한 동물은, 도 12에 나타낸 바와 같이, 비히클 또는 둘라글루티드 처치한 동물에 비해 연구 종료 시 HbA1c 증가의 더 현저한 억제를 나타냈다.

c.) DIO-NASH 마우스 모델

동물 및 실험 설정

모든 동물 실험은 실험실 동물의 관리 및 사용에 대해 국제적으로 인정된 원칙을 준수했다.

5주령의 수컷 C57Bl/6J 마우스를 JanVier(JanVier labs, France)에서 얻었고, 각 그룹에는 12시간 암/12시간 명 주기 하에서 우리당 5마리의 동물을 수용했다. 실내 온도는 22℃ ± 1℃, 습도는 50% ± 10%로 제어했다. 동물은 이전에 AMLN 식단(Clapper et al. (2013) Am J Physiol Gastrointest Liver Physiol 305:G483-G495)으로 기재된 고지방(40%, 이들 중 트랜스 지방 18%), 탄수화물 40%(과당 20%) 및 콜레스테롤 2%(D09100301, Research Diet, 미국), 또는 일반 설치류 식단(Altromin 1324, 덴마크 브로가르덴 소재), 및 수돗물(날씬한 식단, n = 10 내지 12)에 자유롭게 접근하였다. 26주 후, 기준선에서 개별 섬유증 및 지방증 병기(staging)의 조직학적 평가를 위해 간 생검을 수행했다.

생검 하루 전에 마우스를 엔로플록사진(enrofloxazin)(Bayer, 독일)(5 mg/mL/ 1 mL/kg)으로 사전 처치했다. 생검 전에, 마우스를 100% 산소 중 이소플루란(2% 내지 3%)으로 마취시켰다. 정중선에서 작은 복부 절개를 수행하고 간의 왼쪽 측면 엽을 노출시켰다. 간 조직(50 내지 100 mg)의 원추형 웨지를 조직학을 위해 4% 파라포름알데히드에 고정된 엽의 원위 부분에서 절제했다. 이전에 Clapper외 다수가 설명한 생검 절차에 따라 ERBE VIO 100C 전기수술 유닛(ERBE, 미국)을 사용한 양극성 응고법에 의한 간절단면의 전기응고술을 사용하여 정제했다. 간을 복강으로 되돌리고, 복벽을 봉합하고 피부를 스테이플로 고정했다. 카프로펜(Carprofen)(Pfizer, 미국)(5 mg/mL 내지 0.01 mL/10 g)과 엔로플록사신(5 mg/mL 내지 1 mL/kg)을 수술 당시와 수술 후 1일 및 2일에 복강내 투여하였고, 이들은 각각 수술 후 통증 완화 및 감염을 제어한다. 생검 절차 후 동물을 단독 수용하고 회복을 위해 3주 동안 AMLN 식이를 유지했다. 10 내지 12마리 동물의 연구 그룹으로의 계층화 및 무작위화는 기준선 간 생검에 의해 평가된 바와 같은 개별 질환 병기를 기반으로 했다.

그런 다음 동물을 추가 8주 동안 AMLN 또는 식단 식이에 기반하여 50 mg/kg GLP-1RA/FGF21 Fc 융합 단백질, 0.6 mg/kg 둘라글루티드 또는 비히클(PBS)로 매주 1회 피하 주사로 처치했다. 이어서 동물을 안락사시키고, 간 중량을 측정하고, 조직학적 및 생화학적 분석을 위해 간 조직을 수집했다(도 13 참조).

조직학 평가 및 디지털 이미지 분석

기준선 간 생검 및 말단 샘플을 왼쪽 측면 엽(약 100 mg)에서 수집하고 4% 파라포름알데히드에 밤새 고정했다. 간 조직을 파라핀 포매하고 절편화했다(두께 3 μm). 간 형태와 섬유화를 평가하기 위해, 절편을 각각 헤마톡실린(Hematoxylin)과 에오신(Eosin) 및 시리우스 레드(Sirius Red)로 염색한 다음, Visiomorph 소프트웨어(Visiopharm, 덴마크)로 분석했다. 조직학적 평가 및 채점을 연구에 블라인드된 병리학자를 통해 수행했다. NAFLD 활동 점수(NAS)(지방증, 염증, 팽창 변성) 및 섬유증 단계는 문헌(Kleiner et al. (2005) Hepatology 41: 1313-1321)에 개괄된 임상 기준을 사용하여 결정했다. 데이터는 도 14와 도 15에 두 가지 다른 형식으로 제시되어 있다.

서열번호: 8의 융합 단백질은 간 무게, 간 총 지질 함량, 간 콜레스테롤 및 트리글리세리드 함량 및 NAFLD 활성 점수에 대해 GLP-1 효능제 단독에 비해 우수한 효과를 명확하게 나타내며, 후자는 둘라글루티드의 효과임을 예시적으로 보여준다.

SEQUENCE LISTING <110> SANOFI <120> GLP-1R Agonistic Peptides With Reduced Activity <130> 589-334 PCT <160> 636 <170> PatentIn version 3.5 <210> 1 <211> 471 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 1 His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Leu Glu Glu 1 5 10 15 Glu Arg Val Gln Leu Phe Ile Glu Trp Leu Lys Ala Thr Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser Gly Gly Gly Gly Gly Gly Gly Ser Gly 35 40 45 Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Asp Lys Thr His Thr Cys 50 55 60 Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu 65 70 75 80 Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 85 90 95 Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 100 105 110 Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 115 120 125 Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 130 135 140 Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 145 150 155 160 Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 165 170 175 Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 180 185 190 Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 195 200 205 Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 210 215 220 Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 225 230 235 240 Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 245 250 255 Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 260 265 270 His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Ser 275 280 285 Gly Ser Ala His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe Gly 290 295 300 Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Cys Gln Thr 305 310 315 320 Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly Ala Ala 325 330 335 Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys Pro Gly 340 345 350 Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys Gln Arg 355 360 365 Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu Ala Cys 370 375 380 Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr Gln Ser 385 390 395 400 Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Cys Lys Ser Pro His 405 410 415 Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu Pro Gly 420 425 430 Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro Gln Pro 435 440 445 Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly Ser Gln Gly 450 455 460 Arg Ser Pro Ser Tyr Ala Ser 465 470 <210> 2 <211> 472 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 2 His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Leu Glu Glu 1 5 10 15 Glu Arg Val Gln Leu Phe Ile Glu Trp Leu Lys Ala Thr Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser Gly Gly Gly Gly Gly Gly Gly Ser Gly 35 40 45 Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Asp Lys Thr His Thr Cys 50 55 60 Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu 65 70 75 80 Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 85 90 95 Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 100 105 110 Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 115 120 125 Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 130 135 140 Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 145 150 155 160 Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 165 170 175 Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 180 185 190 Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 195 200 205 Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 210 215 220 Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 225 230 235 240 Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 245 250 255 Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 260 265 270 His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Ser 275 280 285 Gly Ser Ala His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe Gly 290 295 300 Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Cys Gln Thr 305 310 315 320 Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly Ala Ala 325 330 335 Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys Pro Gly 340 345 350 Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys Gln Arg 355 360 365 Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu Ala Cys 370 375 380 Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr Gln Ser 385 390 395 400 Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Cys Lys Ser Pro His 405 410 415 Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu Pro Gly 420 425 430 Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro Gln Pro 435 440 445 Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Tyr Pro Ser Gln 450 455 460 Gly Arg Ser Pro Ser Tyr Ala Ser 465 470 <210> 3 <211> 472 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 3 Gly His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Lys Gln Leu Glu 1 5 10 15 Glu Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Ala Gly Gly Pro 20 25 30 Lys Lys Ile Arg Tyr Ser Gly Gly Gly Gly Gly Gly Gly Ser Gly Gly 35 40 45 Gly Gly Ser Gly Gly Gly Gly Ser Ala Glu Ser Lys Tyr Gly Pro Pro 50 55 60 Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val Phe 65 70 75 80 Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 85 90 95 Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val 100 105 110 Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 115 120 125 Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val 130 135 140 Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 145 150 155 160 Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser 165 170 175 Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 180 185 190 Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 195 200 205 Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 210 215 220 Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 225 230 235 240 Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp 245 250 255 Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 260 265 270 Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Gly Gly Gly 275 280 285 Ser Gly Ser Ala His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe 290 295 300 Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Cys Gln 305 310 315 320 Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly Ala 325 330 335 Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys Pro 340 345 350 Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys Gln 355 360 365 Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu Ala 370 375 380 Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr Gln 385 390 395 400 Ser Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Cys Lys Ser Pro 405 410 415 His Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu Pro 420 425 430 Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro Gln 435 440 445 Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly Ser Gln 450 455 460 Gly Arg Ser Pro Ser Tyr Ala Ser 465 470 <210> 4 <211> 473 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 4 His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Leu Glu Glu 1 5 10 15 Glu Arg Val Gln Leu Phe Ile Glu Trp Leu Lys Ala Thr Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser Gly Gly Gly Gly Gly Gly Gly Ser Gly 35 40 45 Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Glu Ser Lys Tyr Gly Pro 50 55 60 Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val 65 70 75 80 Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 85 90 95 Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 100 105 110 Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 115 120 125 Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 130 135 140 Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 145 150 155 160 Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 165 170 175 Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 180 185 190 Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 195 200 205 Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 210 215 220 Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 225 230 235 240 Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 245 250 255 Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 260 265 270 His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Gly Gly 275 280 285 Gly Ser Gly Ser Ala His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln 290 295 300 Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Cys 305 310 315 320 Gln Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly 325 330 335 Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys 340 345 350 Pro Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys 355 360 365 Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu 370 375 380 Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr 385 390 395 400 Gln Ser Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Cys Lys Ser 405 410 415 Pro His Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu 420 425 430 Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro 435 440 445 Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly Ser 450 455 460 Gln Gly Arg Ser Pro Ser Tyr Ala Ser 465 470 <210> 5 <211> 473 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 5 Gly His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Lys Gln Leu Glu 1 5 10 15 Glu Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Ala Gly Gly Pro 20 25 30 Lys Lys Ile Arg Tyr Ser Gly Gly Gly Gly Gly Gly Gly Ser Gly Gly 35 40 45 Gly Gly Ser Gly Gly Gly Gly Ser Ala Glu Ser Lys Tyr Gly Pro Pro 50 55 60 Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val Phe 65 70 75 80 Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 85 90 95 Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val 100 105 110 Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 115 120 125 Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val 130 135 140 Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 145 150 155 160 Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser 165 170 175 Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 180 185 190 Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 195 200 205 Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 210 215 220 Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 225 230 235 240 Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp 245 250 255 Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 260 265 270 Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Gly Gly Gly 275 280 285 Ser Gly Ser Ala His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe 290 295 300 Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Cys Gln 305 310 315 320 Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly Ala 325 330 335 Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys Pro 340 345 350 Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys Gln 355 360 365 Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu Ala 370 375 380 Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr Gln 385 390 395 400 Ser Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Cys Lys Ser Pro 405 410 415 His Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu Pro 420 425 430 Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro Gln 435 440 445 Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Tyr Pro Ser 450 455 460 Gln Gly Arg Ser Pro Ser Tyr Ala Ser 465 470 <210> 6 <211> 474 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 6 His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Leu Glu Glu 1 5 10 15 Glu Arg Val Gln Leu Phe Ile Glu Trp Leu Lys Ala Thr Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser Gly Gly Gly Gly Gly Gly Gly Ser Gly 35 40 45 Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Glu Ser Lys Tyr Gly Pro 50 55 60 Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val 65 70 75 80 Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 85 90 95 Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 100 105 110 Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 115 120 125 Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 130 135 140 Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 145 150 155 160 Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 165 170 175 Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 180 185 190 Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 195 200 205 Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 210 215 220 Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 225 230 235 240 Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 245 250 255 Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 260 265 270 His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Gly Gly 275 280 285 Gly Ser Gly Ser Ala His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln 290 295 300 Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Cys 305 310 315 320 Gln Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly 325 330 335 Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys 340 345 350 Pro Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys 355 360 365 Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu 370 375 380 Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr 385 390 395 400 Gln Ser Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Cys Lys Ser 405 410 415 Pro His Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu 420 425 430 Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro 435 440 445 Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Tyr Pro 450 455 460 Ser Gln Gly Arg Ser Pro Ser Tyr Ala Ser 465 470 <210> 7 <211> 470 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 7 Gly His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Lys Gln Leu Glu 1 5 10 15 Glu Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Ala Gly Gly Pro 20 25 30 Lys Lys Ile Arg Tyr Ser Gly Gly Gly Gly Gly Gly Gly Ser Gly Gly 35 40 45 Gly Gly Ser Gly Gly Gly Gly Ser Ala Asp Lys Thr His Thr Cys Pro 50 55 60 Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe 65 70 75 80 Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 85 90 95 Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 100 105 110 Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 115 120 125 Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 130 135 140 Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 145 150 155 160 Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 165 170 175 Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 180 185 190 Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 195 200 205 Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 210 215 220 Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 225 230 235 240 Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 245 250 255 Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 260 265 270 Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Ser Gly 275 280 285 Ser Ala His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly 290 295 300 Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Cys Gln Thr Glu 305 310 315 320 Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly Ala Ala Asp 325 330 335 Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys Pro Gly Val 340 345 350 Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys Gln Arg Pro 355 360 365 Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu Ala Cys Ser 370 375 380 Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr Gln Ser Glu 385 390 395 400 Ala His Gly Leu Pro Leu His Leu Pro Gly Cys Lys Ser Pro His Arg 405 410 415 Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu Pro Gly Leu 420 425 430 Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro Gln Pro Pro 435 440 445 Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly Ser Gln Gly Arg 450 455 460 Ser Pro Ser Tyr Ala Ser 465 470 <210> 8 <211> 471 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 8 Gly His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Lys Gln Leu Glu 1 5 10 15 Glu Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Ala Gly Gly Pro 20 25 30 Lys Lys Ile Arg Tyr Ser Gly Gly Gly Gly Gly Gly Gly Ser Gly Gly 35 40 45 Gly Gly Ser Gly Gly Gly Gly Ser Ala Asp Lys Thr His Thr Cys Pro 50 55 60 Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe 65 70 75 80 Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 85 90 95 Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 100 105 110 Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 115 120 125 Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 130 135 140 Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 145 150 155 160 Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 165 170 175 Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 180 185 190 Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 195 200 205 Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 210 215 220 Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 225 230 235 240 Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 245 250 255 Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 260 265 270 Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Ser Gly 275 280 285 Ser Ala His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly 290 295 300 Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Cys Gln Thr Glu 305 310 315 320 Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly Ala Ala Asp 325 330 335 Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys Pro Gly Val 340 345 350 Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys Gln Arg Pro 355 360 365 Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu Ala Cys Ser 370 375 380 Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr Gln Ser Glu 385 390 395 400 Ala His Gly Leu Pro Leu His Leu Pro Gly Cys Lys Ser Pro His Arg 405 410 415 Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu Pro Gly Leu 420 425 430 Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro Gln Pro Pro 435 440 445 Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Tyr Pro Ser Gln Gly 450 455 460 Arg Ser Pro Ser Tyr Ala Ser 465 470 <210> 9 <211> 467 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 9 His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Glu 1 5 10 15 Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser Glu Ser Lys Tyr Gly Pro Pro Cys Pro 35 40 45 Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val Phe Leu Phe 50 55 60 Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 65 70 75 80 Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe 85 90 95 Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 100 105 110 Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 115 120 125 Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 130 135 140 Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala 145 150 155 160 Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln 165 170 175 Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 180 185 190 Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 195 200 205 Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 210 215 220 Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu 225 230 235 240 Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 245 250 255 Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Gly Gly Gly Gly Gly 260 265 270 Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala His Pro 275 280 285 Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln Val Arg Gln 290 295 300 Arg Tyr Leu Tyr Thr Asp Asp Ala Gln Gln Thr Glu Ala His Leu Glu 305 310 315 320 Ile Arg Glu Asp Gly Thr Val Gly Gly Ala Ala Asp Gln Ser Pro Glu 325 330 335 Ser Leu Leu Gln Leu Lys Ala Leu Lys Pro Gly Val Ile Gln Ile Leu 340 345 350 Gly Val Lys Thr Ser Arg Phe Leu Cys Gln Arg Pro Asp Gly Ala Leu 355 360 365 Tyr Gly Ser Leu His Phe Asp Pro Glu Ala Cys Ser Phe Arg Glu Leu 370 375 380 Leu Leu Glu Asp Gly Tyr Asn Val Tyr Gln Ser Glu Ala His Gly Leu 385 390 395 400 Pro Leu His Leu Pro Gly Asn Lys Ser Pro His Arg Asp Pro Ala Pro 405 410 415 Arg Gly Pro Ala Arg Phe Leu Pro Leu Pro Gly Leu Pro Pro Ala Pro 420 425 430 Pro Glu Pro Pro Gly Ile Leu Ala Pro Gln Pro Pro Asp Val Gly Ser 435 440 445 Ser Asp Pro Leu Ser Met Val Gly Pro Ser Gln Gly Arg Ser Pro Ser 450 455 460 Tyr Ala Ser 465 <210> 10 <211> 463 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 10 His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Glu 1 5 10 15 Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser Glu Ser Lys Tyr Gly Pro Pro Cys Pro 35 40 45 Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val Phe Leu Phe 50 55 60 Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 65 70 75 80 Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe 85 90 95 Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 100 105 110 Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 115 120 125 Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 130 135 140 Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala 145 150 155 160 Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln 165 170 175 Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 180 185 190 Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 195 200 205 Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 210 215 220 Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu 225 230 235 240 Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 245 250 255 Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Gly Gly Gly Ser Gly 260 265 270 Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala His Pro Ile Pro Asp Ser 275 280 285 Ser Pro Leu Leu Gln Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr 290 295 300 Thr Asp Asp Ala Gln Gln Thr Glu Ala His Leu Glu Ile Arg Glu Asp 305 310 315 320 Gly Thr Val Gly Gly Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln 325 330 335 Leu Lys Ala Leu Lys Pro Gly Val Ile Gln Ile Leu Gly Val Lys Thr 340 345 350 Ser Arg Phe Leu Cys Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu 355 360 365 His Phe Asp Pro Glu Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp 370 375 380 Gly Tyr Asn Val Tyr Gln Ser Glu Ala His Gly Leu Pro Leu His Leu 385 390 395 400 Pro Gly Asn Lys Ser Pro His Arg Asp Pro Ala Pro Arg Gly Pro Ala 405 410 415 Arg Phe Leu Pro Leu Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro 420 425 430 Gly Ile Leu Ala Pro Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu 435 440 445 Ser Met Val Gly Pro Ser Gln Gly Arg Ser Pro Ser Tyr Ala Ser 450 455 460 <210> 11 <211> 459 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 11 His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Glu 1 5 10 15 Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser Glu Ser Lys Tyr Gly Pro Pro Cys Pro 35 40 45 Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val Phe Leu Phe 50 55 60 Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 65 70 75 80 Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe 85 90 95 Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 100 105 110 Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 115 120 125 Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 130 135 140 Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala 145 150 155 160 Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln 165 170 175 Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 180 185 190 Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 195 200 205 Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 210 215 220 Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu 225 230 235 240 Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 245 250 255 Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Gly Gly Gly Ser Gly 260 265 270 Gly Ser Gly Gly Ser Ala His Pro Ile Pro Asp Ser Ser Pro Leu Leu 275 280 285 Gln Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala 290 295 300 Gln Gln Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly 305 310 315 320 Gly Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu 325 330 335 Lys Pro Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu 340 345 350 Cys Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro 355 360 365 Glu Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val 370 375 380 Tyr Gln Ser Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Asn Lys 385 390 395 400 Ser Pro His Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro 405 410 415 Leu Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala 420 425 430 Pro Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly 435 440 445 Pro Ser Gln Gly Arg Ser Pro Ser Tyr Ala Ser 450 455 <210> 12 <211> 455 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 12 His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Glu 1 5 10 15 Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser Glu Ser Lys Tyr Gly Pro Pro Cys Pro 35 40 45 Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val Phe Leu Phe 50 55 60 Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 65 70 75 80 Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe 85 90 95 Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 100 105 110 Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 115 120 125 Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 130 135 140 Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala 145 150 155 160 Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln 165 170 175 Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 180 185 190 Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 195 200 205 Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 210 215 220 Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu 225 230 235 240 Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 245 250 255 Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Gly Gly Gly Ser Gly 260 265 270 Ser Ala His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly 275 280 285 Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Gln Gln Thr Glu 290 295 300 Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly Ala Ala Asp 305 310 315 320 Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys Pro Gly Val 325 330 335 Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys Gln Arg Pro 340 345 350 Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu Ala Cys Ser 355 360 365 Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr Gln Ser Glu 370 375 380 Ala His Gly Leu Pro Leu His Leu Pro Gly Asn Lys Ser Pro His Arg 385 390 395 400 Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu Pro Gly Leu 405 410 415 Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro Gln Pro Pro 420 425 430 Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly Pro Ser Gln Gly 435 440 445 Arg Ser Pro Ser Tyr Ala Ser 450 455 <210> 13 <211> 462 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 13 His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Glu 1 5 10 15 Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser Gly Gly Gly Ser Gly Ser Ala Glu Ser 35 40 45 Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly 50 55 60 Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 65 70 75 80 Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln 85 90 95 Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val 100 105 110 His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr 115 120 125 Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 130 135 140 Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile 145 150 155 160 Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 165 170 175 Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser 180 185 190 Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 195 200 205 Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 210 215 220 Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val 225 230 235 240 Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met 245 250 255 His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 260 265 270 Leu Gly Gly Gly Gly Ser Gly Ser Ala His Pro Ile Pro Asp Ser Ser 275 280 285 Pro Leu Leu Gln Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr 290 295 300 Asp Asp Ala Gln Gln Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly 305 310 315 320 Thr Val Gly Gly Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu 325 330 335 Lys Ala Leu Lys Pro Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser 340 345 350 Arg Phe Leu Cys Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His 355 360 365 Phe Asp Pro Glu Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly 370 375 380 Tyr Asn Val Tyr Gln Ser Glu Ala His Gly Leu Pro Leu His Leu Pro 385 390 395 400 Gly Asn Lys Ser Pro His Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg 405 410 415 Phe Leu Pro Leu Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly 420 425 430 Ile Leu Ala Pro Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser 435 440 445 Met Val Gly Pro Ser Gln Gly Arg Ser Pro Ser Tyr Ala Ser 450 455 460 <210> 14 <211> 466 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 14 His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Glu 1 5 10 15 Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser Gly Gly Gly Ser Gly Gly Ser Gly Gly 35 40 45 Ser Ala Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro 50 55 60 Glu Phe Glu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 65 70 75 80 Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 85 90 95 Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 100 105 110 Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 115 120 125 Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 130 135 140 Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 145 150 155 160 Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 165 170 175 Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 180 185 190 Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 195 200 205 Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 210 215 220 Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 225 230 235 240 Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 245 250 255 Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 260 265 270 Leu Ser Leu Ser Leu Gly Gly Gly Gly Ser Gly Ser Ala His Pro Ile 275 280 285 Pro Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln Val Arg Gln Arg 290 295 300 Tyr Leu Tyr Thr Asp Asp Ala Gln Gln Thr Glu Ala His Leu Glu Ile 305 310 315 320 Arg Glu Asp Gly Thr Val Gly Gly Ala Ala Asp Gln Ser Pro Glu Ser 325 330 335 Leu Leu Gln Leu Lys Ala Leu Lys Pro Gly Val Ile Gln Ile Leu Gly 340 345 350 Val Lys Thr Ser Arg Phe Leu Cys Gln Arg Pro Asp Gly Ala Leu Tyr 355 360 365 Gly Ser Leu His Phe Asp Pro Glu Ala Cys Ser Phe Arg Glu Leu Leu 370 375 380 Leu Glu Asp Gly Tyr Asn Val Tyr Gln Ser Glu Ala His Gly Leu Pro 385 390 395 400 Leu His Leu Pro Gly Asn Lys Ser Pro His Arg Asp Pro Ala Pro Arg 405 410 415 Gly Pro Ala Arg Phe Leu Pro Leu Pro Gly Leu Pro Pro Ala Pro Pro 420 425 430 Glu Pro Pro Gly Ile Leu Ala Pro Gln Pro Pro Asp Val Gly Ser Ser 435 440 445 Asp Pro Leu Ser Met Val Gly Pro Ser Gln Gly Arg Ser Pro Ser Tyr 450 455 460 Ala Ser 465 <210> 15 <211> 470 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 15 His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Glu 1 5 10 15 Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser 35 40 45 Gly Gly Gly Gly Ser Ala Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro 50 55 60 Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val Phe Leu Phe Pro 65 70 75 80 Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 85 90 95 Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn 100 105 110 Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 115 120 125 Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 130 135 140 Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 145 150 155 160 Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys 165 170 175 Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu 180 185 190 Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 195 200 205 Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 210 215 220 Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 225 230 235 240 Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly 245 250 255 Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 260 265 270 Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Gly Gly Gly Ser Gly Ser 275 280 285 Ala His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln 290 295 300 Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Gln Gln Thr Glu Ala 305 310 315 320 His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly Ala Ala Asp Gln 325 330 335 Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys Pro Gly Val Ile 340 345 350 Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys Gln Arg Pro Asp 355 360 365 Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu Ala Cys Ser Phe 370 375 380 Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr Gln Ser Glu Ala 385 390 395 400 His Gly Leu Pro Leu His Leu Pro Gly Asn Lys Ser Pro His Arg Asp 405 410 415 Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu Pro Gly Leu Pro 420 425 430 Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro Gln Pro Pro Asp 435 440 445 Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly Pro Ser Gln Gly Arg 450 455 460 Ser Pro Ser Tyr Ala Ser 465 470 <210> 16 <211> 473 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 16 His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Leu Glu Glu 1 5 10 15 Glu Arg Val Gln Leu Phe Ile Glu Trp Leu Lys Ala Thr Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser Gly Gly Gly Gly Gly Gly Gly Ser Gly 35 40 45 Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Glu Ser Lys Tyr Gly Pro 50 55 60 Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val 65 70 75 80 Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 85 90 95 Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 100 105 110 Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 115 120 125 Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 130 135 140 Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 145 150 155 160 Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 165 170 175 Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 180 185 190 Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 195 200 205 Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 210 215 220 Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 225 230 235 240 Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 245 250 255 Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 260 265 270 His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Gly Gly 275 280 285 Gly Ser Gly Ser Ala His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln 290 295 300 Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Cys 305 310 315 320 Gln Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly 325 330 335 Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys 340 345 350 Pro Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys 355 360 365 Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu 370 375 380 Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr 385 390 395 400 Gln Ser Glu Ala His Gly Leu Pro Leu His Leu Cys Gly Asn Lys Ser 405 410 415 Pro His Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu 420 425 430 Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro 435 440 445 Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly Ser 450 455 460 Gln Gly Arg Ser Pro Ser Tyr Ala Ser 465 470 <210> 17 <211> 474 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 17 His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Leu Glu Glu 1 5 10 15 Glu Arg Val Gln Leu Phe Ile Glu Trp Leu Lys Ala Thr Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser Gly Gly Gly Gly Gly Gly Gly Ser Gly 35 40 45 Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Glu Ser Lys Tyr Gly Pro 50 55 60 Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val 65 70 75 80 Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 85 90 95 Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 100 105 110 Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 115 120 125 Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 130 135 140 Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 145 150 155 160 Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 165 170 175 Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 180 185 190 Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 195 200 205 Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 210 215 220 Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 225 230 235 240 Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 245 250 255 Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 260 265 270 His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Gly Gly 275 280 285 Gly Ser Gly Ser Ala His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln 290 295 300 Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Cys 305 310 315 320 Gln Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly 325 330 335 Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys 340 345 350 Pro Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys 355 360 365 Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu 370 375 380 Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr 385 390 395 400 Gln Ser Glu Ala His Gly Leu Pro Leu His Leu Cys Gly Asn Lys Ser 405 410 415 Pro His Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu 420 425 430 Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro 435 440 445 Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Tyr Pro 450 455 460 Ser Gln Gly Arg Ser Pro Ser Tyr Ala Ser 465 470 <210> 18 <211> 473 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 18 His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Leu Glu Glu 1 5 10 15 Glu Arg Val Gln Glu Phe Ile Glu Trp Leu Lys Ala Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser Gly Gly Gly Gly Gly Gly Gly Ser Gly 35 40 45 Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Glu Ser Lys Tyr Gly Pro 50 55 60 Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val 65 70 75 80 Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 85 90 95 Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 100 105 110 Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 115 120 125 Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 130 135 140 Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 145 150 155 160 Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 165 170 175 Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 180 185 190 Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 195 200 205 Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 210 215 220 Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 225 230 235 240 Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 245 250 255 Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 260 265 270 His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Gly Gly 275 280 285 Gly Ser Gly Ser Ala His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln 290 295 300 Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Cys 305 310 315 320 Gln Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly 325 330 335 Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys 340 345 350 Pro Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys 355 360 365 Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu 370 375 380 Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr 385 390 395 400 Gln Ser Glu Ala His Gly Leu Pro Leu His Leu Cys Gly Asn Lys Ser 405 410 415 Pro His Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu 420 425 430 Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro 435 440 445 Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly Ser 450 455 460 Gln Gly Arg Ser Pro Ser Tyr Ala Ser 465 470 <210> 19 <211> 474 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 19 His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Leu Glu Glu 1 5 10 15 Glu Arg Val Gln Glu Phe Ile Glu Trp Leu Lys Ala Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser Gly Gly Gly Gly Gly Gly Gly Ser Gly 35 40 45 Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Glu Ser Lys Tyr Gly Pro 50 55 60 Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val 65 70 75 80 Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 85 90 95 Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 100 105 110 Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 115 120 125 Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 130 135 140 Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 145 150 155 160 Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 165 170 175 Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 180 185 190 Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 195 200 205 Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 210 215 220 Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 225 230 235 240 Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 245 250 255 Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 260 265 270 His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Gly Gly 275 280 285 Gly Ser Gly Ser Ala His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln 290 295 300 Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Cys 305 310 315 320 Gln Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly 325 330 335 Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys 340 345 350 Pro Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys 355 360 365 Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu 370 375 380 Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr 385 390 395 400 Gln Ser Glu Ala His Gly Leu Pro Leu His Leu Cys Gly Asn Lys Ser 405 410 415 Pro His Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu 420 425 430 Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro 435 440 445 Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Tyr Pro 450 455 460 Ser Gln Gly Arg Ser Pro Ser Tyr Ala Ser 465 470 <210> 20 <211> 474 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 20 His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Leu Glu Glu 1 5 10 15 Glu Arg Val Gln Glu Phe Ile Glu Trp Leu Lys Ala Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser Gly Gly Gly Gly Gly Gly Gly Ser Gly 35 40 45 Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Glu Ser Lys Tyr Gly Pro 50 55 60 Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val 65 70 75 80 Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 85 90 95 Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 100 105 110 Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 115 120 125 Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 130 135 140 Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 145 150 155 160 Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 165 170 175 Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 180 185 190 Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 195 200 205 Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 210 215 220 Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 225 230 235 240 Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 245 250 255 Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 260 265 270 His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Gly Gly 275 280 285 Gly Ser Gly Ser Ala His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln 290 295 300 Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Cys 305 310 315 320 Gln Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly 325 330 335 Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys 340 345 350 Pro Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys 355 360 365 Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu 370 375 380 Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr 385 390 395 400 Gln Ser Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Cys Lys Ser 405 410 415 Pro His Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu 420 425 430 Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro 435 440 445 Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Tyr Pro 450 455 460 Ser Gln Gly Arg Ser Pro Ser Tyr Ala Ser 465 470 <210> 21 <211> 473 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 21 His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Ile Gln Leu Glu Glu 1 5 10 15 Glu Ala Val Gln Glu Phe Ile Glu Trp Leu Leu Ala Thr Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser Gly Gly Gly Gly Gly Gly Gly Ser Gly 35 40 45 Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Glu Ser Lys Tyr Gly Pro 50 55 60 Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val 65 70 75 80 Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 85 90 95 Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 100 105 110 Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 115 120 125 Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 130 135 140 Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 145 150 155 160 Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 165 170 175 Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 180 185 190 Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 195 200 205 Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 210 215 220 Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 225 230 235 240 Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 245 250 255 Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 260 265 270 His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Gly Gly 275 280 285 Gly Ser Gly Ser Ala His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln 290 295 300 Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Cys 305 310 315 320 Gln Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly 325 330 335 Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys 340 345 350 Pro Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys 355 360 365 Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu 370 375 380 Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr 385 390 395 400 Gln Ser Glu Ala His Gly Leu Pro Leu His Leu Cys Gly Asn Lys Ser 405 410 415 Pro His Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu 420 425 430 Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro 435 440 445 Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly Ser 450 455 460 Gln Gly Arg Ser Pro Ser Tyr Ala Ser 465 470 <210> 22 <211> 474 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 22 His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Ile Gln Leu Glu Glu 1 5 10 15 Glu Ala Val Gln Glu Phe Ile Glu Trp Leu Leu Ala Thr Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser Gly Gly Gly Gly Gly Gly Gly Ser Gly 35 40 45 Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Glu Ser Lys Tyr Gly Pro 50 55 60 Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val 65 70 75 80 Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 85 90 95 Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 100 105 110 Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 115 120 125 Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 130 135 140 Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 145 150 155 160 Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 165 170 175 Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 180 185 190 Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 195 200 205 Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 210 215 220 Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 225 230 235 240 Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 245 250 255 Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 260 265 270 His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Gly Gly 275 280 285 Gly Ser Gly Ser Ala His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln 290 295 300 Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Cys 305 310 315 320 Gln Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly 325 330 335 Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys 340 345 350 Pro Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys 355 360 365 Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu 370 375 380 Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr 385 390 395 400 Gln Ser Glu Ala His Gly Leu Pro Leu His Leu Cys Gly Asn Lys Ser 405 410 415 Pro His Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu 420 425 430 Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro 435 440 445 Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Tyr Pro 450 455 460 Ser Gln Gly Arg Ser Pro Ser Tyr Ala Ser 465 470 <210> 23 <211> 473 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 23 His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Ile Gln Leu Glu Glu 1 5 10 15 Glu Ala Val Gln Glu Phe Ile Glu Trp Leu Leu Ala Thr Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser Gly Gly Gly Gly Gly Gly Gly Ser Gly 35 40 45 Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Glu Ser Lys Tyr Gly Pro 50 55 60 Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val 65 70 75 80 Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 85 90 95 Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 100 105 110 Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 115 120 125 Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 130 135 140 Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 145 150 155 160 Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 165 170 175 Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 180 185 190 Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 195 200 205 Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 210 215 220 Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 225 230 235 240 Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 245 250 255 Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 260 265 270 His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Gly Gly 275 280 285 Gly Ser Gly Ser Ala His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln 290 295 300 Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Cys 305 310 315 320 Gln Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly 325 330 335 Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys 340 345 350 Pro Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys 355 360 365 Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu 370 375 380 Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr 385 390 395 400 Gln Ser Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Cys Lys Ser 405 410 415 Pro His Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu 420 425 430 Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro 435 440 445 Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly Ser 450 455 460 Gln Gly Arg Ser Pro Ser Tyr Ala Ser 465 470 <210> 24 <211> 474 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 24 His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Ile Gln Leu Glu Glu 1 5 10 15 Glu Ala Val Gln Glu Phe Ile Glu Trp Leu Leu Ala Thr Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser Gly Gly Gly Gly Gly Gly Gly Ser Gly 35 40 45 Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Glu Ser Lys Tyr Gly Pro 50 55 60 Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val 65 70 75 80 Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 85 90 95 Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 100 105 110 Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 115 120 125 Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 130 135 140 Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 145 150 155 160 Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 165 170 175 Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 180 185 190 Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 195 200 205 Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 210 215 220 Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 225 230 235 240 Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 245 250 255 Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 260 265 270 His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Gly Gly 275 280 285 Gly Ser Gly Ser Ala His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln 290 295 300 Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Cys 305 310 315 320 Gln Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly 325 330 335 Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys 340 345 350 Pro Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys 355 360 365 Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu 370 375 380 Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr 385 390 395 400 Gln Ser Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Cys Lys Ser 405 410 415 Pro His Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu 420 425 430 Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro 435 440 445 Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Tyr Pro 450 455 460 Ser Gln Gly Arg Ser Pro Ser Tyr Ala Ser 465 470 <210> 25 <211> 473 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 25 His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Ile Leu Leu Asp Glu 1 5 10 15 Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Leu Ala Thr Gly Pro Val 20 25 30 Ser Gly Ala Pro Pro Pro Ser Gly Gly Gly Gly Gly Gly Gly Ser Gly 35 40 45 Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Glu Ser Lys Tyr Gly Pro 50 55 60 Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val 65 70 75 80 Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 85 90 95 Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 100 105 110 Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 115 120 125 Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 130 135 140 Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 145 150 155 160 Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 165 170 175 Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 180 185 190 Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 195 200 205 Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 210 215 220 Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 225 230 235 240 Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 245 250 255 Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 260 265 270 His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Gly Gly 275 280 285 Gly Ser Gly Ser Ala His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln 290 295 300 Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Cys 305 310 315 320 Gln Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly 325 330 335 Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys 340 345 350 Pro Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys 355 360 365 Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu 370 375 380 Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr 385 390 395 400 Gln Ser Glu Ala His Gly Leu Pro Leu His Leu Cys Gly Asn Lys Ser 405 410 415 Pro His Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu 420 425 430 Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro 435 440 445 Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly Ser 450 455 460 Gln Gly Arg Ser Pro Ser Tyr Ala Ser 465 470 <210> 26 <211> 473 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 26 His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Ile Leu Leu Asp Glu 1 5 10 15 Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Leu Ala Thr Gly Pro Val 20 25 30 Ser Gly Ala Pro Pro Pro Ser Gly Gly Gly Gly Gly Gly Gly Ser Gly 35 40 45 Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Glu Ser Lys Tyr Gly Pro 50 55 60 Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val 65 70 75 80 Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 85 90 95 Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 100 105 110 Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 115 120 125 Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 130 135 140 Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 145 150 155 160 Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 165 170 175 Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 180 185 190 Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 195 200 205 Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 210 215 220 Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 225 230 235 240 Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 245 250 255 Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 260 265 270 His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Gly Gly 275 280 285 Gly Ser Gly Ser Ala His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln 290 295 300 Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Cys 305 310 315 320 Gln Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly 325 330 335 Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys 340 345 350 Pro Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys 355 360 365 Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu 370 375 380 Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr 385 390 395 400 Gln Ser Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Cys Lys Ser 405 410 415 Pro His Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu 420 425 430 Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro 435 440 445 Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly Ser 450 455 460 Gln Gly Arg Ser Pro Ser Tyr Ala Ser 465 470 <210> 27 <211> 474 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 27 His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Ile Leu Leu Asp Glu 1 5 10 15 Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Leu Ala Thr Gly Pro Val 20 25 30 Ser Gly Ala Pro Pro Pro Ser Gly Gly Gly Gly Gly Gly Gly Ser Gly 35 40 45 Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Glu Ser Lys Tyr Gly Pro 50 55 60 Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val 65 70 75 80 Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 85 90 95 Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 100 105 110 Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 115 120 125 Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 130 135 140 Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 145 150 155 160 Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 165 170 175 Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 180 185 190 Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 195 200 205 Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 210 215 220 Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 225 230 235 240 Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 245 250 255 Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 260 265 270 His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Gly Gly 275 280 285 Gly Ser Gly Ser Ala His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln 290 295 300 Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Cys 305 310 315 320 Gln Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly 325 330 335 Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys 340 345 350 Pro Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys 355 360 365 Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu 370 375 380 Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr 385 390 395 400 Gln Ser Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Cys Lys Ser 405 410 415 Pro His Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu 420 425 430 Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro 435 440 445 Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Tyr Pro 450 455 460 Ser Gln Gly Arg Ser Pro Ser Tyr Ala Ser 465 470 <210> 28 <211> 473 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 28 His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Ile Leu Leu Asp Glu 1 5 10 15 Glu Ala Val Arg Glu Phe Ile Glu Trp Leu Leu Ala Thr Gly Pro Val 20 25 30 Ser Gly Ala Pro Pro Pro Ser Gly Gly Gly Gly Gly Gly Gly Ser Gly 35 40 45 Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Glu Ser Lys Tyr Gly Pro 50 55 60 Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val 65 70 75 80 Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 85 90 95 Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 100 105 110 Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 115 120 125 Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 130 135 140 Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 145 150 155 160 Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 165 170 175 Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 180 185 190 Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 195 200 205 Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 210 215 220 Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 225 230 235 240 Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 245 250 255 Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 260 265 270 His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Gly Gly 275 280 285 Gly Ser Gly Ser Ala His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln 290 295 300 Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Cys 305 310 315 320 Gln Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly 325 330 335 Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys 340 345 350 Pro Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys 355 360 365 Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu 370 375 380 Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr 385 390 395 400 Gln Ser Glu Ala His Gly Leu Pro Leu His Leu Cys Gly Asn Lys Ser 405 410 415 Pro His Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu 420 425 430 Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro 435 440 445 Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly Ser 450 455 460 Gln Gly Arg Ser Pro Ser Tyr Ala Ser 465 470 <210> 29 <211> 474 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 29 His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Ile Leu Leu Asp Glu 1 5 10 15 Glu Ala Val Arg Glu Phe Ile Glu Trp Leu Leu Ala Thr Gly Pro Val 20 25 30 Ser Gly Ala Pro Pro Pro Ser Gly Gly Gly Gly Gly Gly Gly Ser Gly 35 40 45 Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Glu Ser Lys Tyr Gly Pro 50 55 60 Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val 65 70 75 80 Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 85 90 95 Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 100 105 110 Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 115 120 125 Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 130 135 140 Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 145 150 155 160 Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 165 170 175 Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 180 185 190 Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 195 200 205 Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 210 215 220 Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 225 230 235 240 Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 245 250 255 Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 260 265 270 His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Gly Gly 275 280 285 Gly Ser Gly Ser Ala His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln 290 295 300 Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Cys 305 310 315 320 Gln Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly 325 330 335 Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys 340 345 350 Pro Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys 355 360 365 Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu 370 375 380 Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr 385 390 395 400 Gln Ser Glu Ala His Gly Leu Pro Leu His Leu Cys Gly Asn Lys Ser 405 410 415 Pro His Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu 420 425 430 Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro 435 440 445 Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Tyr Pro 450 455 460 Ser Gln Gly Arg Ser Pro Ser Tyr Ala Ser 465 470 <210> 30 <211> 473 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 30 His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Ile Leu Leu Asp Glu 1 5 10 15 Glu Ala Val Arg Glu Phe Ile Glu Trp Leu Leu Ala Thr Gly Pro Val 20 25 30 Ser Gly Ala Pro Pro Pro Ser Gly Gly Gly Gly Gly Gly Gly Ser Gly 35 40 45 Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Glu Ser Lys Tyr Gly Pro 50 55 60 Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val 65 70 75 80 Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 85 90 95 Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 100 105 110 Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 115 120 125 Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 130 135 140 Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 145 150 155 160 Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 165 170 175 Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 180 185 190 Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 195 200 205 Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 210 215 220 Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 225 230 235 240 Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 245 250 255 Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 260 265 270 His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Gly Gly 275 280 285 Gly Ser Gly Ser Ala His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln 290 295 300 Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Cys 305 310 315 320 Gln Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly 325 330 335 Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys 340 345 350 Pro Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys 355 360 365 Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu 370 375 380 Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr 385 390 395 400 Gln Ser Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Cys Lys Ser 405 410 415 Pro His Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu 420 425 430 Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro 435 440 445 Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly Ser 450 455 460 Gln Gly Arg Ser Pro Ser Tyr Ala Ser 465 470 <210> 31 <211> 474 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 31 His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Ile Leu Leu Asp Glu 1 5 10 15 Glu Ala Val Arg Glu Phe Ile Glu Trp Leu Leu Ala Thr Gly Pro Val 20 25 30 Ser Gly Ala Pro Pro Pro Ser Gly Gly Gly Gly Gly Gly Gly Ser Gly 35 40 45 Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Glu Ser Lys Tyr Gly Pro 50 55 60 Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val 65 70 75 80 Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 85 90 95 Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 100 105 110 Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 115 120 125 Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 130 135 140 Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 145 150 155 160 Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 165 170 175 Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 180 185 190 Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 195 200 205 Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 210 215 220 Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 225 230 235 240 Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 245 250 255 Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 260 265 270 His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Gly Gly 275 280 285 Gly Ser Gly Ser Ala His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln 290 295 300 Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Cys 305 310 315 320 Gln Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly 325 330 335 Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys 340 345 350 Pro Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys 355 360 365 Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu 370 375 380 Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr 385 390 395 400 Gln Ser Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Cys Lys Ser 405 410 415 Pro His Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu 420 425 430 Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro 435 440 445 Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Tyr Pro 450 455 460 Ser Gln Gly Arg Ser Pro Ser Tyr Ala Ser 465 470 <210> 32 <211> 472 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 32 His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Glu 1 5 10 15 Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser Gly Gly Gly Gly Gly Gly Gly Ser Gly 35 40 45 Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Asp Lys Thr His Thr Cys 50 55 60 Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu 65 70 75 80 Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 85 90 95 Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 100 105 110 Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 115 120 125 Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 130 135 140 Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 145 150 155 160 Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 165 170 175 Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 180 185 190 Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 195 200 205 Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 210 215 220 Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 225 230 235 240 Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 245 250 255 Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 260 265 270 His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Ser 275 280 285 Gly Ser Ala His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe Gly 290 295 300 Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Cys Gln Thr 305 310 315 320 Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly Ala Ala 325 330 335 Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys Pro Gly 340 345 350 Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys Gln Arg 355 360 365 Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu Ala Cys 370 375 380 Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr Gln Ser 385 390 395 400 Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Cys Lys Ser Pro His 405 410 415 Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu Pro Gly 420 425 430 Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro Gln Pro 435 440 445 Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Tyr Pro Ser Gln 450 455 460 Gly Arg Ser Pro Ser Tyr Ala Ser 465 470 <210> 33 <211> 471 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 33 His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Leu Glu Glu 1 5 10 15 Glu Arg Val Gln Leu Phe Ile Glu Trp Leu Lys Ala Thr Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser Gly Gly Gly Gly Gly Gly Gly Ser Gly 35 40 45 Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Asp Lys Thr His Thr Cys 50 55 60 Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu 65 70 75 80 Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 85 90 95 Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 100 105 110 Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 115 120 125 Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 130 135 140 Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 145 150 155 160 Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 165 170 175 Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 180 185 190 Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 195 200 205 Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 210 215 220 Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 225 230 235 240 Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 245 250 255 Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 260 265 270 His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Ser 275 280 285 Gly Ser Ala His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe Gly 290 295 300 Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Cys Gln Thr 305 310 315 320 Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly Ala Ala 325 330 335 Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys Pro Gly 340 345 350 Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys Gln Arg 355 360 365 Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu Ala Cys 370 375 380 Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr Gln Ser 385 390 395 400 Glu Ala His Gly Leu Pro Leu His Leu Cys Gly Asn Lys Ser Pro His 405 410 415 Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu Pro Gly 420 425 430 Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro Gln Pro 435 440 445 Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly Ser Gln Gly 450 455 460 Arg Ser Pro Ser Tyr Ala Ser 465 470 <210> 34 <211> 472 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 34 His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Leu Glu Glu 1 5 10 15 Glu Arg Val Gln Leu Phe Ile Glu Trp Leu Lys Ala Thr Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser Gly Gly Gly Gly Gly Gly Gly Ser Gly 35 40 45 Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Asp Lys Thr His Thr Cys 50 55 60 Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu 65 70 75 80 Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 85 90 95 Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 100 105 110 Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 115 120 125 Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 130 135 140 Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 145 150 155 160 Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 165 170 175 Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 180 185 190 Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 195 200 205 Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 210 215 220 Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 225 230 235 240 Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 245 250 255 Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 260 265 270 His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Ser 275 280 285 Gly Ser Ala His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe Gly 290 295 300 Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Cys Gln Thr 305 310 315 320 Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly Ala Ala 325 330 335 Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys Pro Gly 340 345 350 Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys Gln Arg 355 360 365 Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu Ala Cys 370 375 380 Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr Gln Ser 385 390 395 400 Glu Ala His Gly Leu Pro Leu His Leu Cys Gly Asn Lys Ser Pro His 405 410 415 Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu Pro Gly 420 425 430 Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro Gln Pro 435 440 445 Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Tyr Pro Ser Gln 450 455 460 Gly Arg Ser Pro Ser Tyr Ala Ser 465 470 <210> 35 <211> 471 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 35 His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Leu Glu Glu 1 5 10 15 Glu Arg Val Gln Glu Phe Ile Glu Trp Leu Lys Ala Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser Gly Gly Gly Gly Gly Gly Gly Ser Gly 35 40 45 Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Asp Lys Thr His Thr Cys 50 55 60 Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu 65 70 75 80 Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 85 90 95 Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 100 105 110 Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 115 120 125 Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 130 135 140 Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 145 150 155 160 Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 165 170 175 Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 180 185 190 Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 195 200 205 Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 210 215 220 Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 225 230 235 240 Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 245 250 255 Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 260 265 270 His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Ser 275 280 285 Gly Ser Ala His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe Gly 290 295 300 Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Cys Gln Thr 305 310 315 320 Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly Ala Ala 325 330 335 Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys Pro Gly 340 345 350 Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys Gln Arg 355 360 365 Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu Ala Cys 370 375 380 Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr Gln Ser 385 390 395 400 Glu Ala His Gly Leu Pro Leu His Leu Cys Gly Asn Lys Ser Pro His 405 410 415 Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu Pro Gly 420 425 430 Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro Gln Pro 435 440 445 Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly Ser Gln Gly 450 455 460 Arg Ser Pro Ser Tyr Ala Ser 465 470 <210> 36 <211> 472 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 36 His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Leu Glu Glu 1 5 10 15 Glu Arg Val Gln Glu Phe Ile Glu Trp Leu Lys Ala Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser Gly Gly Gly Gly Gly Gly Gly Ser Gly 35 40 45 Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Asp Lys Thr His Thr Cys 50 55 60 Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu 65 70 75 80 Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 85 90 95 Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 100 105 110 Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 115 120 125 Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 130 135 140 Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 145 150 155 160 Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 165 170 175 Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 180 185 190 Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 195 200 205 Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 210 215 220 Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 225 230 235 240 Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 245 250 255 Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 260 265 270 His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Ser 275 280 285 Gly Ser Ala His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe Gly 290 295 300 Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Cys Gln Thr 305 310 315 320 Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly Ala Ala 325 330 335 Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys Pro Gly 340 345 350 Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys Gln Arg 355 360 365 Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu Ala Cys 370 375 380 Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr Gln Ser 385 390 395 400 Glu Ala His Gly Leu Pro Leu His Leu Cys Gly Asn Lys Ser Pro His 405 410 415 Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu Pro Gly 420 425 430 Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro Gln Pro 435 440 445 Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Tyr Pro Ser Gln 450 455 460 Gly Arg Ser Pro Ser Tyr Ala Ser 465 470 <210> 37 <211> 471 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 37 His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Leu Glu Glu 1 5 10 15 Glu Arg Val Gln Glu Phe Ile Glu Trp Leu Lys Ala Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser Gly Gly Gly Gly Gly Gly Gly Ser Gly 35 40 45 Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Asp Lys Thr His Thr Cys 50 55 60 Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu 65 70 75 80 Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 85 90 95 Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 100 105 110 Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 115 120 125 Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 130 135 140 Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 145 150 155 160 Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 165 170 175 Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 180 185 190 Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 195 200 205 Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 210 215 220 Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 225 230 235 240 Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 245 250 255 Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 260 265 270 His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Ser 275 280 285 Gly Ser Ala His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe Gly 290 295 300 Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Cys Gln Thr 305 310 315 320 Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly Ala Ala 325 330 335 Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys Pro Gly 340 345 350 Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys Gln Arg 355 360 365 Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu Ala Cys 370 375 380 Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr Gln Ser 385 390 395 400 Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Cys Lys Ser Pro His 405 410 415 Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu Pro Gly 420 425 430 Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro Gln Pro 435 440 445 Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly Ser Gln Gly 450 455 460 Arg Ser Pro Ser Tyr Ala Ser 465 470 <210> 38 <211> 471 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 38 His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Leu Glu Glu 1 5 10 15 Glu Ala Val Gln Leu Phe Ile Glu Trp Leu Leu Ala Thr Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser Gly Gly Gly Gly Gly Gly Gly Ser Gly 35 40 45 Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Asp Lys Thr His Thr Cys 50 55 60 Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu 65 70 75 80 Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 85 90 95 Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 100 105 110 Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 115 120 125 Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 130 135 140 Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 145 150 155 160 Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 165 170 175 Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 180 185 190 Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 195 200 205 Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 210 215 220 Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 225 230 235 240 Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 245 250 255 Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 260 265 270 His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Ser 275 280 285 Gly Ser Ala His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe Gly 290 295 300 Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Cys Gln Thr 305 310 315 320 Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly Ala Ala 325 330 335 Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys Pro Gly 340 345 350 Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys Gln Arg 355 360 365 Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu Ala Cys 370 375 380 Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr Gln Ser 385 390 395 400 Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Cys Lys Ser Pro His 405 410 415 Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu Pro Gly 420 425 430 Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro Gln Pro 435 440 445 Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly Ser Gln Gly 450 455 460 Arg Ser Pro Ser Tyr Ala Ser 465 470 <210> 39 <211> 471 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 39 His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Ile Gln Leu Glu Glu 1 5 10 15 Glu Ala Val Gln Glu Phe Ile Glu Trp Leu Leu Ala Thr Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser Gly Gly Gly Gly Gly Gly Gly Ser Gly 35 40 45 Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Asp Lys Thr His Thr Cys 50 55 60 Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu 65 70 75 80 Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 85 90 95 Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 100 105 110 Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 115 120 125 Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 130 135 140 Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 145 150 155 160 Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 165 170 175 Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 180 185 190 Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 195 200 205 Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 210 215 220 Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 225 230 235 240 Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 245 250 255 Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 260 265 270 His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Ser 275 280 285 Gly Ser Ala His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe Gly 290 295 300 Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Cys Gln Thr 305 310 315 320 Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly Ala Ala 325 330 335 Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys Pro Gly 340 345 350 Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys Gln Arg 355 360 365 Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu Ala Cys 370 375 380 Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr Gln Ser 385 390 395 400 Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Cys Lys Ser Pro His 405 410 415 Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu Pro Gly 420 425 430 Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro Gln Pro 435 440 445 Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly Ser Gln Gly 450 455 460 Arg Ser Pro Ser Tyr Ala Ser 465 470 <210> 40 <211> 472 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 40 Gly His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Ile Gln Leu Glu 1 5 10 15 Glu Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Leu Ala Gly Gly Pro 20 25 30 Ser Ser Gly Ala Pro Pro Pro Ser Gly Gly Gly Gly Gly Gly Gly Ser 35 40 45 Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Asp Lys Thr His Thr 50 55 60 Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe 65 70 75 80 Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 85 90 95 Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 100 105 110 Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 115 120 125 Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 130 135 140 Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 145 150 155 160 Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 165 170 175 Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 180 185 190 Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 195 200 205 Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 210 215 220 Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 225 230 235 240 Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 245 250 255 Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 260 265 270 Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly 275 280 285 Ser Gly Ser Ala His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe 290 295 300 Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Cys Gln 305 310 315 320 Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly Ala 325 330 335 Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys Pro 340 345 350 Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys Gln 355 360 365 Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu Ala 370 375 380 Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr Gln 385 390 395 400 Ser Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Cys Lys Ser Pro 405 410 415 His Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu Pro 420 425 430 Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro Gln 435 440 445 Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly Ser Gln 450 455 460 Gly Arg Ser Pro Ser Tyr Ala Ser 465 470 <210> 41 <211> 472 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 41 Gly His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Ile Gln Leu Glu 1 5 10 15 Glu Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Leu Ala Thr Gly Pro 20 25 30 Ser Ser Gly Ala Pro Pro Pro Ser Gly Gly Gly Gly Gly Gly Gly Ser 35 40 45 Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Asp Lys Thr His Thr 50 55 60 Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe 65 70 75 80 Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 85 90 95 Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 100 105 110 Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 115 120 125 Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 130 135 140 Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 145 150 155 160 Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 165 170 175 Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 180 185 190 Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 195 200 205 Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 210 215 220 Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 225 230 235 240 Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 245 250 255 Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 260 265 270 Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly 275 280 285 Ser Gly Ser Ala His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe 290 295 300 Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Cys Gln 305 310 315 320 Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly Ala 325 330 335 Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys Pro 340 345 350 Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys Gln 355 360 365 Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu Ala 370 375 380 Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr Gln 385 390 395 400 Ser Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Cys Lys Ser Pro 405 410 415 His Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu Pro 420 425 430 Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro Gln 435 440 445 Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly Ser Gln 450 455 460 Gly Arg Ser Pro Ser Tyr Ala Ser 465 470 <210> 42 <211> 471 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 42 His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Ile Gln Leu Asp Glu 1 5 10 15 Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Leu Ala Thr Gly Pro Val 20 25 30 Ser Gly Ala Pro Pro Pro Ser Gly Gly Gly Gly Gly Gly Gly Ser Gly 35 40 45 Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Asp Lys Thr His Thr Cys 50 55 60 Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu 65 70 75 80 Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 85 90 95 Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 100 105 110 Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 115 120 125 Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 130 135 140 Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 145 150 155 160 Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 165 170 175 Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 180 185 190 Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 195 200 205 Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 210 215 220 Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 225 230 235 240 Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 245 250 255 Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 260 265 270 His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Ser 275 280 285 Gly Ser Ala His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe Gly 290 295 300 Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Cys Gln Thr 305 310 315 320 Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly Ala Ala 325 330 335 Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys Pro Gly 340 345 350 Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys Gln Arg 355 360 365 Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu Ala Cys 370 375 380 Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr Gln Ser 385 390 395 400 Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Cys Lys Ser Pro His 405 410 415 Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu Pro Gly 420 425 430 Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro Gln Pro 435 440 445 Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly Ser Gln Gly 450 455 460 Arg Ser Pro Ser Tyr Ala Ser 465 470 <210> 43 <211> 471 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 43 His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Ile Leu Leu Asp Glu 1 5 10 15 Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Leu Ala Thr Gly Pro Val 20 25 30 Ser Gly Ala Pro Pro Pro Ser Gly Gly Gly Gly Gly Gly Gly Ser Gly 35 40 45 Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Asp Lys Thr His Thr Cys 50 55 60 Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu 65 70 75 80 Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 85 90 95 Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 100 105 110 Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 115 120 125 Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 130 135 140 Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 145 150 155 160 Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 165 170 175 Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 180 185 190 Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 195 200 205 Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 210 215 220 Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 225 230 235 240 Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 245 250 255 Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 260 265 270 His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Ser 275 280 285 Gly Ser Ala His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe Gly 290 295 300 Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Cys Gln Thr 305 310 315 320 Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly Ala Ala 325 330 335 Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys Pro Gly 340 345 350 Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys Gln Arg 355 360 365 Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu Ala Cys 370 375 380 Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr Gln Ser 385 390 395 400 Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Cys Lys Ser Pro His 405 410 415 Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu Pro Gly 420 425 430 Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro Gln Pro 435 440 445 Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly Ser Gln Gly 450 455 460 Arg Ser Pro Ser Tyr Ala Ser 465 470 <210> 44 <211> 471 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 44 His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Ile Gln Leu Asp Glu 1 5 10 15 Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Glu Ala Thr Gly Pro Val 20 25 30 Ser Gly Ala Pro Pro Pro Ser Gly Gly Gly Gly Gly Gly Gly Ser Gly 35 40 45 Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Asp Lys Thr His Thr Cys 50 55 60 Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu 65 70 75 80 Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 85 90 95 Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 100 105 110 Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 115 120 125 Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 130 135 140 Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 145 150 155 160 Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 165 170 175 Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 180 185 190 Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 195 200 205 Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 210 215 220 Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 225 230 235 240 Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 245 250 255 Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 260 265 270 His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Ser 275 280 285 Gly Ser Ala His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe Gly 290 295 300 Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Cys Gln Thr 305 310 315 320 Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly Ala Ala 325 330 335 Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys Pro Gly 340 345 350 Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys Gln Arg 355 360 365 Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu Ala Cys 370 375 380 Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr Gln Ser 385 390 395 400 Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Cys Lys Ser Pro His 405 410 415 Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu Pro Gly 420 425 430 Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro Gln Pro 435 440 445 Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly Ser Gln Gly 450 455 460 Arg Ser Pro Ser Tyr Ala Ser 465 470 <210> 45 <211> 472 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 45 His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Ile Gln Leu Asp Glu 1 5 10 15 Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Glu Ala Thr Gly Pro Val 20 25 30 Ser Gly Ala Pro Pro Pro Ser Gly Gly Gly Gly Gly Gly Gly Ser Gly 35 40 45 Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Asp Lys Thr His Thr Cys 50 55 60 Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu 65 70 75 80 Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 85 90 95 Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 100 105 110 Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 115 120 125 Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 130 135 140 Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 145 150 155 160 Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 165 170 175 Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 180 185 190 Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 195 200 205 Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 210 215 220 Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 225 230 235 240 Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 245 250 255 Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 260 265 270 His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Ser 275 280 285 Gly Ser Ala His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe Gly 290 295 300 Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Cys Gln Thr 305 310 315 320 Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly Ala Ala 325 330 335 Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys Pro Gly 340 345 350 Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys Gln Arg 355 360 365 Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu Ala Cys 370 375 380 Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr Gln Ser 385 390 395 400 Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Cys Lys Ser Pro His 405 410 415 Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu Pro Gly 420 425 430 Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro Gln Pro 435 440 445 Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Tyr Pro Ser Gln 450 455 460 Gly Arg Ser Pro Ser Tyr Ala Ser 465 470 <210> 46 <211> 471 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 46 His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Ile Leu Leu Asp Glu 1 5 10 15 Glu Ala Val Arg Glu Phe Ile Glu Trp Leu Leu Ala Thr Gly Pro Val 20 25 30 Ser Gly Ala Pro Pro Pro Ser Gly Gly Gly Gly Gly Gly Gly Ser Gly 35 40 45 Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Asp Lys Thr His Thr Cys 50 55 60 Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu 65 70 75 80 Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 85 90 95 Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 100 105 110 Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 115 120 125 Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 130 135 140 Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 145 150 155 160 Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 165 170 175 Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 180 185 190 Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 195 200 205 Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 210 215 220 Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 225 230 235 240 Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 245 250 255 Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 260 265 270 His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Ser 275 280 285 Gly Ser Ala His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe Gly 290 295 300 Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Cys Gln Thr 305 310 315 320 Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly Ala Ala 325 330 335 Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys Pro Gly 340 345 350 Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys Gln Arg 355 360 365 Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu Ala Cys 370 375 380 Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr Gln Ser 385 390 395 400 Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Cys Lys Ser Pro His 405 410 415 Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu Pro Gly 420 425 430 Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro Gln Pro 435 440 445 Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly Ser Gln Gly 450 455 460 Arg Ser Pro Ser Tyr Ala Ser 465 470 <210> 47 <211> 475 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 47 His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Leu Glu Glu 1 5 10 15 Glu Ala Val Gln Leu Phe Ile Glu Trp Leu Leu Ala Thr Gly Pro Ser 20 25 30 Ser Gly Lys Pro Pro Pro Lys Ser Gly Gly Gly Gly Gly Gly Gly Ser 35 40 45 Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Glu Ser Lys Tyr Gly 50 55 60 Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser 65 70 75 80 Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 85 90 95 Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro 100 105 110 Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 115 120 125 Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val 130 135 140 Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 145 150 155 160 Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr 165 170 175 Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 180 185 190 Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 195 200 205 Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 210 215 220 Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 225 230 235 240 Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser 245 250 255 Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 260 265 270 Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Gly 275 280 285 Gly Gly Ser Gly Ser Ala His Pro Ile Pro Asp Ser Ser Pro Leu Leu 290 295 300 Gln Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala 305 310 315 320 Cys Gln Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly 325 330 335 Gly Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu 340 345 350 Lys Pro Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu 355 360 365 Cys Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro 370 375 380 Glu Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val 385 390 395 400 Tyr Gln Ser Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Cys Lys 405 410 415 Ser Pro His Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro 420 425 430 Leu Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala 435 440 445 Pro Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Tyr 450 455 460 Pro Ser Gln Gly Arg Ser Pro Ser Tyr Ala Ser 465 470 475 <210> 48 <211> 475 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 48 His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Leu Glu Glu 1 5 10 15 Glu Ala Val Gln Leu Phe Ile Glu Trp Leu Leu Ala Thr Gly Pro Ser 20 25 30 Ser Gly Lys Pro Pro Pro Glu Ser Gly Gly Gly Gly Gly Gly Gly Ser 35 40 45 Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Glu Ser Lys Tyr Gly 50 55 60 Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser 65 70 75 80 Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 85 90 95 Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro 100 105 110 Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 115 120 125 Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val 130 135 140 Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 145 150 155 160 Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr 165 170 175 Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 180 185 190 Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 195 200 205 Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 210 215 220 Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 225 230 235 240 Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser 245 250 255 Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 260 265 270 Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Gly 275 280 285 Gly Gly Ser Gly Ser Ala His Pro Ile Pro Asp Ser Ser Pro Leu Leu 290 295 300 Gln Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala 305 310 315 320 Cys Gln Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly 325 330 335 Gly Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu 340 345 350 Lys Pro Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu 355 360 365 Cys Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro 370 375 380 Glu Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val 385 390 395 400 Tyr Gln Ser Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Cys Lys 405 410 415 Ser Pro His Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro 420 425 430 Leu Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala 435 440 445 Pro Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Tyr 450 455 460 Pro Ser Gln Gly Arg Ser Pro Ser Tyr Ala Ser 465 470 475 <210> 49 <211> 475 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 49 His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Leu Glu Glu 1 5 10 15 Glu Ala Val Gln Leu Phe Ile Glu Trp Leu Leu Ala Thr Gly Pro Ser 20 25 30 Ser Gly Glu Pro Pro Pro Lys Ser Gly Gly Gly Gly Gly Gly Gly Ser 35 40 45 Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Glu Ser Lys Tyr Gly 50 55 60 Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser 65 70 75 80 Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 85 90 95 Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro 100 105 110 Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 115 120 125 Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val 130 135 140 Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 145 150 155 160 Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr 165 170 175 Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 180 185 190 Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 195 200 205 Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 210 215 220 Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 225 230 235 240 Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser 245 250 255 Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 260 265 270 Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Gly 275 280 285 Gly Gly Ser Gly Ser Ala His Pro Ile Pro Asp Ser Ser Pro Leu Leu 290 295 300 Gln Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala 305 310 315 320 Cys Gln Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly 325 330 335 Gly Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu 340 345 350 Lys Pro Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu 355 360 365 Cys Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro 370 375 380 Glu Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val 385 390 395 400 Tyr Gln Ser Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Cys Lys 405 410 415 Ser Pro His Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro 420 425 430 Leu Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala 435 440 445 Pro Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Tyr 450 455 460 Pro Ser Gln Gly Arg Ser Pro Ser Tyr Ala Ser 465 470 475 <210> 50 <211> 474 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 50 His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Leu Glu Glu 1 5 10 15 Glu Ala Val Gln Leu Phe Ile Glu Trp Leu Leu Ala Thr Gly Pro Ser 20 25 30 Ser Gly Lys Pro Pro Pro Lys Gly Gly Gly Gly Gly Gly Gly Ser Gly 35 40 45 Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Glu Ser Lys Tyr Gly Pro 50 55 60 Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val 65 70 75 80 Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 85 90 95 Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 100 105 110 Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 115 120 125 Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 130 135 140 Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 145 150 155 160 Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 165 170 175 Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 180 185 190 Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 195 200 205 Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 210 215 220 Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 225 230 235 240 Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 245 250 255 Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 260 265 270 His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Gly Gly 275 280 285 Gly Ser Gly Ser Ala His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln 290 295 300 Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Cys 305 310 315 320 Gln Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly 325 330 335 Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys 340 345 350 Pro Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys 355 360 365 Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu 370 375 380 Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr 385 390 395 400 Gln Ser Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Cys Lys Ser 405 410 415 Pro His Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu 420 425 430 Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro 435 440 445 Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Tyr Pro 450 455 460 Ser Gln Gly Arg Ser Pro Ser Tyr Ala Ser 465 470 <210> 51 <211> 474 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 51 His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Leu Glu Glu 1 5 10 15 Glu Ala Val Gln Leu Phe Ile Glu Trp Leu Leu Ala Thr Gly Pro Ser 20 25 30 Ser Gly Lys Pro Pro Pro Glu Gly Gly Gly Gly Gly Gly Gly Ser Gly 35 40 45 Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Glu Ser Lys Tyr Gly Pro 50 55 60 Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val 65 70 75 80 Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 85 90 95 Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 100 105 110 Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 115 120 125 Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 130 135 140 Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 145 150 155 160 Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 165 170 175 Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 180 185 190 Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 195 200 205 Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 210 215 220 Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 225 230 235 240 Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 245 250 255 Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 260 265 270 His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Gly Gly 275 280 285 Gly Ser Gly Ser Ala His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln 290 295 300 Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Cys 305 310 315 320 Gln Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly 325 330 335 Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys 340 345 350 Pro Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys 355 360 365 Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu 370 375 380 Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr 385 390 395 400 Gln Ser Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Cys Lys Ser 405 410 415 Pro His Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu 420 425 430 Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro 435 440 445 Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Tyr Pro 450 455 460 Ser Gln Gly Arg Ser Pro Ser Tyr Ala Ser 465 470 <210> 52 <211> 474 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 52 His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Leu Glu Glu 1 5 10 15 Glu Ala Val Gln Leu Phe Ile Glu Trp Leu Leu Ala Thr Gly Pro Ser 20 25 30 Ser Gly Glu Pro Pro Pro Lys Gly Gly Gly Gly Gly Gly Gly Ser Gly 35 40 45 Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Glu Ser Lys Tyr Gly Pro 50 55 60 Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val 65 70 75 80 Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 85 90 95 Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 100 105 110 Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 115 120 125 Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 130 135 140 Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 145 150 155 160 Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 165 170 175 Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 180 185 190 Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 195 200 205 Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 210 215 220 Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 225 230 235 240 Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 245 250 255 Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 260 265 270 His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Gly Gly 275 280 285 Gly Ser Gly Ser Ala His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln 290 295 300 Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Cys 305 310 315 320 Gln Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly 325 330 335 Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys 340 345 350 Pro Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys 355 360 365 Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu 370 375 380 Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr 385 390 395 400 Gln Ser Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Cys Lys Ser 405 410 415 Pro His Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu 420 425 430 Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro 435 440 445 Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Tyr Pro 450 455 460 Ser Gln Gly Arg Ser Pro Ser Tyr Ala Ser 465 470 <210> 53 <211> 473 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 53 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Lys Gln Leu Asp Glu 1 5 10 15 Gln Arg Ala Lys Glu Phe Ile Glu Trp Leu Lys Ala Gly Gly His Pro 20 25 30 Ser Gly Lys Pro Pro Pro Lys Gly Gly Gly Gly Gly Gly Gly Ser Gly 35 40 45 Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Glu Ser Lys Tyr Gly Pro 50 55 60 Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val 65 70 75 80 Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 85 90 95 Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 100 105 110 Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 115 120 125 Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 130 135 140 Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 145 150 155 160 Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 165 170 175 Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 180 185 190 Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 195 200 205 Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 210 215 220 Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 225 230 235 240 Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 245 250 255 Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 260 265 270 His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Gly Gly 275 280 285 Gly Ser Gly Ser Ala His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln 290 295 300 Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Cys 305 310 315 320 Gln Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly 325 330 335 Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys 340 345 350 Pro Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys 355 360 365 Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu 370 375 380 Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr 385 390 395 400 Gln Ser Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Cys Lys Ser 405 410 415 Pro His Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu 420 425 430 Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro 435 440 445 Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly Ser 450 455 460 Gln Gly Arg Ser Pro Ser Tyr Ala Ser 465 470 <210> 54 <211> 474 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 54 Gly His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Lys Gln Leu Glu 1 5 10 15 Glu Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Ala Gly Gly His 20 25 30 Pro Ser Gly Lys Pro Pro Pro Lys Gly Gly Gly Gly Gly Gly Gly Ser 35 40 45 Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Glu Ser Lys Tyr Gly 50 55 60 Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser 65 70 75 80 Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 85 90 95 Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro 100 105 110 Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 115 120 125 Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val 130 135 140 Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 145 150 155 160 Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr 165 170 175 Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 180 185 190 Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 195 200 205 Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 210 215 220 Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 225 230 235 240 Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser 245 250 255 Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 260 265 270 Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Gly 275 280 285 Gly Gly Ser Gly Ser Ala His Pro Ile Pro Asp Ser Ser Pro Leu Leu 290 295 300 Gln Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala 305 310 315 320 Cys Gln Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly 325 330 335 Gly Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu 340 345 350 Lys Pro Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu 355 360 365 Cys Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro 370 375 380 Glu Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val 385 390 395 400 Tyr Gln Ser Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Cys Lys 405 410 415 Ser Pro His Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro 420 425 430 Leu Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala 435 440 445 Pro Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly 450 455 460 Ser Gln Gly Arg Ser Pro Ser Tyr Ala Ser 465 470 <210> 55 <211> 474 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 55 Gly His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Ile Gln Leu Glu 1 5 10 15 Glu Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Leu Ala Gly Gly His 20 25 30 Pro Ser Gly Lys Pro Pro Pro Lys Gly Gly Gly Gly Gly Gly Gly Ser 35 40 45 Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Glu Ser Lys Tyr Gly 50 55 60 Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser 65 70 75 80 Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 85 90 95 Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro 100 105 110 Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 115 120 125 Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val 130 135 140 Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 145 150 155 160 Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr 165 170 175 Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 180 185 190 Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 195 200 205 Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 210 215 220 Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 225 230 235 240 Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser 245 250 255 Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 260 265 270 Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Gly 275 280 285 Gly Gly Ser Gly Ser Ala His Pro Ile Pro Asp Ser Ser Pro Leu Leu 290 295 300 Gln Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala 305 310 315 320 Cys Gln Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly 325 330 335 Gly Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu 340 345 350 Lys Pro Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu 355 360 365 Cys Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro 370 375 380 Glu Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val 385 390 395 400 Tyr Gln Ser Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Cys Lys 405 410 415 Ser Pro His Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro 420 425 430 Leu Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala 435 440 445 Pro Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly 450 455 460 Ser Gln Gly Arg Ser Pro Ser Tyr Ala Ser 465 470 <210> 56 <211> 474 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 56 Ala His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Ile Gln Leu Glu 1 5 10 15 Lys Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Leu Ala Gly Gly His 20 25 30 Pro Ser Gly Lys Pro Pro Pro Lys Gly Gly Gly Gly Gly Gly Gly Ser 35 40 45 Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Glu Ser Lys Tyr Gly 50 55 60 Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser 65 70 75 80 Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 85 90 95 Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro 100 105 110 Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 115 120 125 Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val 130 135 140 Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 145 150 155 160 Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr 165 170 175 Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 180 185 190 Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 195 200 205 Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 210 215 220 Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 225 230 235 240 Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser 245 250 255 Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 260 265 270 Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Gly 275 280 285 Gly Gly Ser Gly Ser Ala His Pro Ile Pro Asp Ser Ser Pro Leu Leu 290 295 300 Gln Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala 305 310 315 320 Cys Gln Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly 325 330 335 Gly Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu 340 345 350 Lys Pro Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu 355 360 365 Cys Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro 370 375 380 Glu Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val 385 390 395 400 Tyr Gln Ser Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Cys Lys 405 410 415 Ser Pro His Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro 420 425 430 Leu Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala 435 440 445 Pro Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly 450 455 460 Ser Gln Gly Arg Ser Pro Ser Tyr Ala Ser 465 470 <210> 57 <211> 473 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 57 Tyr Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Gln Leu Leu Glu Lys 1 5 10 15 Arg Leu Ala His Leu Phe Ile Glu Trp Leu Ile Ala Gly Gly His Ser 20 25 30 Ser Gly Lys Pro Pro Pro Lys Gly Gly Gly Gly Gly Gly Gly Ser Gly 35 40 45 Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Glu Ser Lys Tyr Gly Pro 50 55 60 Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val 65 70 75 80 Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 85 90 95 Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 100 105 110 Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 115 120 125 Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 130 135 140 Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 145 150 155 160 Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 165 170 175 Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 180 185 190 Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 195 200 205 Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 210 215 220 Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 225 230 235 240 Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 245 250 255 Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 260 265 270 His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Gly Gly 275 280 285 Gly Ser Gly Ser Ala His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln 290 295 300 Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Cys 305 310 315 320 Gln Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly 325 330 335 Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys 340 345 350 Pro Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys 355 360 365 Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu 370 375 380 Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr 385 390 395 400 Gln Ser Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Cys Lys Ser 405 410 415 Pro His Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu 420 425 430 Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro 435 440 445 Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly Ser 450 455 460 Gln Gly Arg Ser Pro Ser Tyr Ala Ser 465 470 <210> 58 <211> 473 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 58 Tyr Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Lys Leu Leu Glu Lys 1 5 10 15 Arg Leu Val Arg Leu Phe Ile Glu Trp Leu Ile Ala Gly Gly His Ser 20 25 30 Ser Gly Lys Pro Pro Pro Lys Gly Gly Gly Gly Gly Gly Gly Ser Gly 35 40 45 Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Glu Ser Lys Tyr Gly Pro 50 55 60 Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val 65 70 75 80 Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 85 90 95 Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 100 105 110 Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 115 120 125 Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 130 135 140 Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 145 150 155 160 Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 165 170 175 Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 180 185 190 Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 195 200 205 Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 210 215 220 Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 225 230 235 240 Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 245 250 255 Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 260 265 270 His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Gly Gly 275 280 285 Gly Ser Gly Ser Ala His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln 290 295 300 Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Cys 305 310 315 320 Gln Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly 325 330 335 Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys 340 345 350 Pro Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys 355 360 365 Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu 370 375 380 Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr 385 390 395 400 Gln Ser Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Cys Lys Ser 405 410 415 Pro His Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu 420 425 430 Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro 435 440 445 Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly Ser 450 455 460 Gln Gly Arg Ser Pro Ser Tyr Ala Ser 465 470 <210> 59 <211> 473 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 59 Tyr Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Lys Leu Leu Glu Lys 1 5 10 15 Arg Leu Ala His Leu Phe Ile Glu Trp Leu Ile Ala Gly Gly His Ser 20 25 30 Ser Gly Lys Pro Pro Pro Lys Gly Gly Gly Gly Gly Gly Gly Ser Gly 35 40 45 Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Glu Ser Lys Tyr Gly Pro 50 55 60 Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val 65 70 75 80 Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 85 90 95 Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 100 105 110 Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 115 120 125 Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 130 135 140 Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 145 150 155 160 Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 165 170 175 Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 180 185 190 Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 195 200 205 Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 210 215 220 Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 225 230 235 240 Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 245 250 255 Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 260 265 270 His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Gly Gly 275 280 285 Gly Ser Gly Ser Ala His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln 290 295 300 Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Cys 305 310 315 320 Gln Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly 325 330 335 Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys 340 345 350 Pro Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys 355 360 365 Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu 370 375 380 Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr 385 390 395 400 Gln Ser Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Cys Lys Ser 405 410 415 Pro His Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu 420 425 430 Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro 435 440 445 Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly Ser 450 455 460 Gln Gly Arg Ser Pro Ser Tyr Ala Ser 465 470 <210> 60 <211> 473 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 60 Tyr Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Lys Gln Leu Glu Lys 1 5 10 15 Arg Leu Val Arg Leu Phe Ile Glu Trp Leu Ile Ala Gly Gly His Ser 20 25 30 Ser Gly Lys Pro Pro Pro Lys Gly Gly Gly Gly Gly Gly Gly Ser Gly 35 40 45 Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Glu Ser Lys Tyr Gly Pro 50 55 60 Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val 65 70 75 80 Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 85 90 95 Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 100 105 110 Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 115 120 125 Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 130 135 140 Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 145 150 155 160 Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 165 170 175 Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 180 185 190 Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 195 200 205 Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 210 215 220 Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 225 230 235 240 Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 245 250 255 Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 260 265 270 His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Gly Gly 275 280 285 Gly Ser Gly Ser Ala His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln 290 295 300 Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Cys 305 310 315 320 Gln Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly 325 330 335 Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys 340 345 350 Pro Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys 355 360 365 Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu 370 375 380 Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr 385 390 395 400 Gln Ser Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Cys Lys Ser 405 410 415 Pro His Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu 420 425 430 Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro 435 440 445 Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly Ser 450 455 460 Gln Gly Arg Ser Pro Ser Tyr Ala Ser 465 470 <210> 61 <211> 473 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 61 Tyr Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Lys Gln Leu Glu Lys 1 5 10 15 Arg Leu Ala His Leu Phe Ile Glu Trp Leu Ile Ala Gly Gly His Ser 20 25 30 Ser Gly Lys Pro Pro Pro Lys Gly Gly Gly Gly Gly Gly Gly Ser Gly 35 40 45 Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Glu Ser Lys Tyr Gly Pro 50 55 60 Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val 65 70 75 80 Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 85 90 95 Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 100 105 110 Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 115 120 125 Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 130 135 140 Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 145 150 155 160 Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 165 170 175 Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 180 185 190 Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 195 200 205 Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 210 215 220 Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 225 230 235 240 Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 245 250 255 Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 260 265 270 His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Gly Gly 275 280 285 Gly Ser Gly Ser Ala His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln 290 295 300 Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Cys 305 310 315 320 Gln Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly 325 330 335 Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys 340 345 350 Pro Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys 355 360 365 Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu 370 375 380 Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr 385 390 395 400 Gln Ser Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Cys Lys Ser 405 410 415 Pro His Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu 420 425 430 Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro 435 440 445 Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly Ser 450 455 460 Gln Gly Arg Ser Pro Ser Tyr Ala Ser 465 470 <210> 62 <211> 473 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 62 Tyr Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Lys Gln Leu Glu Lys 1 5 10 15 Arg Leu Val Arg Leu Phe Ile Glu Trp Leu Ile Lys Gly Gly His Ser 20 25 30 Ser Gly Lys Pro Pro Pro Lys Gly Gly Gly Gly Gly Gly Gly Ser Gly 35 40 45 Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Glu Ser Lys Tyr Gly Pro 50 55 60 Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val 65 70 75 80 Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 85 90 95 Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 100 105 110 Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 115 120 125 Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 130 135 140 Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 145 150 155 160 Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 165 170 175 Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 180 185 190 Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 195 200 205 Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 210 215 220 Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 225 230 235 240 Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 245 250 255 Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 260 265 270 His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Gly Gly 275 280 285 Gly Ser Gly Ser Ala His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln 290 295 300 Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Cys 305 310 315 320 Gln Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly 325 330 335 Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys 340 345 350 Pro Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys 355 360 365 Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu 370 375 380 Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr 385 390 395 400 Gln Ser Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Cys Lys Ser 405 410 415 Pro His Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu 420 425 430 Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro 435 440 445 Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly Ser 450 455 460 Gln Gly Arg Ser Pro Ser Tyr Ala Ser 465 470 <210> 63 <211> 473 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 63 Tyr Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Lys Gln Leu Glu Lys 1 5 10 15 Arg Leu Ala His Leu Phe Ile Glu Trp Leu Ile Lys Gly Gly His Ser 20 25 30 Ser Gly Lys Pro Pro Pro Lys Gly Gly Gly Gly Gly Gly Gly Ser Gly 35 40 45 Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Glu Ser Lys Tyr Gly Pro 50 55 60 Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val 65 70 75 80 Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 85 90 95 Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 100 105 110 Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 115 120 125 Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 130 135 140 Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 145 150 155 160 Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 165 170 175 Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 180 185 190 Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 195 200 205 Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 210 215 220 Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 225 230 235 240 Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 245 250 255 Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 260 265 270 His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Gly Gly 275 280 285 Gly Ser Gly Ser Ala His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln 290 295 300 Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Cys 305 310 315 320 Gln Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly 325 330 335 Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys 340 345 350 Pro Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys 355 360 365 Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu 370 375 380 Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr 385 390 395 400 Gln Ser Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Cys Lys Ser 405 410 415 Pro His Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu 420 425 430 Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro 435 440 445 Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly Ser 450 455 460 Gln Gly Arg Ser Pro Ser Tyr Ala Ser 465 470 <210> 64 <211> 473 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 64 His Thr Glu Gly Thr Phe Thr Ser Asp Lys Ser Lys Gln Leu Glu Lys 1 5 10 15 Arg Leu Val Arg Leu Phe Ile Glu Trp Leu Ile Lys Gly Gly His Ser 20 25 30 Ser Gly Lys Pro Pro Pro Lys Gly Gly Gly Gly Gly Gly Gly Ser Gly 35 40 45 Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Glu Ser Lys Tyr Gly Pro 50 55 60 Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val 65 70 75 80 Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 85 90 95 Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 100 105 110 Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 115 120 125 Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 130 135 140 Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 145 150 155 160 Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 165 170 175 Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 180 185 190 Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 195 200 205 Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 210 215 220 Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 225 230 235 240 Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 245 250 255 Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 260 265 270 His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Gly Gly 275 280 285 Gly Ser Gly Ser Ala His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln 290 295 300 Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Cys 305 310 315 320 Gln Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly 325 330 335 Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys 340 345 350 Pro Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys 355 360 365 Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu 370 375 380 Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr 385 390 395 400 Gln Ser Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Cys Lys Ser 405 410 415 Pro His Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu 420 425 430 Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro 435 440 445 Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly Ser 450 455 460 Gln Gly Arg Ser Pro Ser Tyr Ala Ser 465 470 <210> 65 <211> 473 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 65 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Lys Gln Leu Ala Lys 1 5 10 15 Arg Leu Val Arg Leu Phe Ile Glu Trp Leu Ile Lys Gly Gly His Ser 20 25 30 Ser Gly Lys Pro Pro Pro Lys Gly Gly Gly Gly Gly Gly Gly Ser Gly 35 40 45 Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Glu Ser Lys Tyr Gly Pro 50 55 60 Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val 65 70 75 80 Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 85 90 95 Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 100 105 110 Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 115 120 125 Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 130 135 140 Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 145 150 155 160 Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 165 170 175 Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 180 185 190 Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 195 200 205 Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 210 215 220 Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 225 230 235 240 Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 245 250 255 Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 260 265 270 His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Gly Gly 275 280 285 Gly Ser Gly Ser Ala His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln 290 295 300 Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Cys 305 310 315 320 Gln Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly 325 330 335 Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys 340 345 350 Pro Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys 355 360 365 Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu 370 375 380 Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr 385 390 395 400 Gln Ser Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Cys Lys Ser 405 410 415 Pro His Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu 420 425 430 Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro 435 440 445 Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly Ser 450 455 460 Gln Gly Arg Ser Pro Ser Tyr Ala Ser 465 470 <210> 66 <211> 472 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 66 Gly His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Lys Gln Leu Glu 1 5 10 15 Glu Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Ala Gly Gly Pro 20 25 30 Lys Lys Gln Arg Leu Ser Gly Gly Gly Gly Gly Gly Gly Ser Gly Gly 35 40 45 Gly Gly Ser Gly Gly Gly Gly Ser Ala Glu Ser Lys Tyr Gly Pro Pro 50 55 60 Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val Phe 65 70 75 80 Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 85 90 95 Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val 100 105 110 Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 115 120 125 Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val 130 135 140 Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 145 150 155 160 Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser 165 170 175 Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 180 185 190 Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 195 200 205 Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 210 215 220 Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 225 230 235 240 Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp 245 250 255 Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 260 265 270 Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Gly Gly Gly 275 280 285 Ser Gly Ser Ala His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe 290 295 300 Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Cys Gln 305 310 315 320 Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly Ala 325 330 335 Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys Pro 340 345 350 Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys Gln 355 360 365 Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu Ala 370 375 380 Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr Gln 385 390 395 400 Ser Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Cys Lys Ser Pro 405 410 415 His Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu Pro 420 425 430 Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro Gln 435 440 445 Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly Ser Gln 450 455 460 Gly Arg Ser Pro Ser Tyr Ala Ser 465 470 <210> 67 <211> 474 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 67 Gly His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Ile Gln Leu Glu 1 5 10 15 Glu Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Leu Ala Gly Gly Pro 20 25 30 Ser Ser Gly Lys Pro Pro Pro Lys Gly Gly Gly Gly Gly Gly Gly Ser 35 40 45 Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Glu Ser Lys Tyr Gly 50 55 60 Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser 65 70 75 80 Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 85 90 95 Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro 100 105 110 Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 115 120 125 Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val 130 135 140 Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 145 150 155 160 Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr 165 170 175 Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 180 185 190 Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 195 200 205 Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 210 215 220 Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 225 230 235 240 Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser 245 250 255 Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 260 265 270 Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Gly 275 280 285 Gly Gly Ser Gly Ser Ala His Pro Ile Pro Asp Ser Ser Pro Leu Leu 290 295 300 Gln Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala 305 310 315 320 Cys Gln Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly 325 330 335 Gly Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu 340 345 350 Lys Pro Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu 355 360 365 Cys Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro 370 375 380 Glu Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val 385 390 395 400 Tyr Gln Ser Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Cys Lys 405 410 415 Ser Pro His Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro 420 425 430 Leu Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala 435 440 445 Pro Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly 450 455 460 Ser Gln Gly Arg Ser Pro Ser Tyr Ala Ser 465 470 <210> 68 <211> 474 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 68 Gly His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Ile Gln Leu Glu 1 5 10 15 Glu Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Leu Ala Gly Gly Pro 20 25 30 Ser Lys Gly Lys Pro Pro Pro Lys Gly Gly Gly Gly Gly Gly Gly Ser 35 40 45 Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Glu Ser Lys Tyr Gly 50 55 60 Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser 65 70 75 80 Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 85 90 95 Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro 100 105 110 Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 115 120 125 Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val 130 135 140 Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 145 150 155 160 Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr 165 170 175 Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 180 185 190 Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 195 200 205 Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 210 215 220 Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 225 230 235 240 Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser 245 250 255 Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 260 265 270 Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Gly 275 280 285 Gly Gly Ser Gly Ser Ala His Pro Ile Pro Asp Ser Ser Pro Leu Leu 290 295 300 Gln Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala 305 310 315 320 Cys Gln Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly 325 330 335 Gly Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu 340 345 350 Lys Pro Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu 355 360 365 Cys Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro 370 375 380 Glu Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val 385 390 395 400 Tyr Gln Ser Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Cys Lys 405 410 415 Ser Pro His Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro 420 425 430 Leu Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala 435 440 445 Pro Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly 450 455 460 Ser Gln Gly Arg Ser Pro Ser Tyr Ala Ser 465 470 <210> 69 <211> 474 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 69 Gly His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Ile Gln Leu Glu 1 5 10 15 Glu Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Leu Ala Gly Gly Pro 20 25 30 Ser Ser Gly Lys Pro Lys Pro Lys Gly Gly Gly Gly Gly Gly Gly Ser 35 40 45 Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Glu Ser Lys Tyr Gly 50 55 60 Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser 65 70 75 80 Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 85 90 95 Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro 100 105 110 Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 115 120 125 Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val 130 135 140 Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 145 150 155 160 Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr 165 170 175 Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 180 185 190 Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 195 200 205 Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 210 215 220 Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 225 230 235 240 Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser 245 250 255 Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 260 265 270 Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Gly 275 280 285 Gly Gly Ser Gly Ser Ala His Pro Ile Pro Asp Ser Ser Pro Leu Leu 290 295 300 Gln Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala 305 310 315 320 Cys Gln Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly 325 330 335 Gly Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu 340 345 350 Lys Pro Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu 355 360 365 Cys Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro 370 375 380 Glu Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val 385 390 395 400 Tyr Gln Ser Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Cys Lys 405 410 415 Ser Pro His Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro 420 425 430 Leu Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala 435 440 445 Pro Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly 450 455 460 Ser Gln Gly Arg Ser Pro Ser Tyr Ala Ser 465 470 <210> 70 <211> 474 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 70 Gly His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Ile Gln Leu Glu 1 5 10 15 Glu Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Leu Ala Lys Gly Lys 20 25 30 Ser Lys Gly Lys Pro Lys Pro Lys Gly Gly Gly Gly Gly Gly Gly Ser 35 40 45 Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Glu Ser Lys Tyr Gly 50 55 60 Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser 65 70 75 80 Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 85 90 95 Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro 100 105 110 Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 115 120 125 Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val 130 135 140 Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 145 150 155 160 Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr 165 170 175 Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 180 185 190 Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 195 200 205 Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 210 215 220 Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 225 230 235 240 Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser 245 250 255 Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 260 265 270 Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Gly 275 280 285 Gly Gly Ser Gly Ser Ala His Pro Ile Pro Asp Ser Ser Pro Leu Leu 290 295 300 Gln Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala 305 310 315 320 Cys Gln Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly 325 330 335 Gly Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu 340 345 350 Lys Pro Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu 355 360 365 Cys Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro 370 375 380 Glu Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val 385 390 395 400 Tyr Gln Ser Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Cys Lys 405 410 415 Ser Pro His Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro 420 425 430 Leu Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala 435 440 445 Pro Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly 450 455 460 Ser Gln Gly Arg Ser Pro Ser Tyr Ala Ser 465 470 <210> 71 <211> 473 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 71 Phe Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Lys Gln Leu Glu Lys 1 5 10 15 Arg Leu Val Arg Leu Phe Ile Glu Trp Leu Ile Ala Gly Gly His Ser 20 25 30 Ser Gly Lys Pro Pro Pro Lys Gly Gly Gly Gly Gly Gly Gly Ser Gly 35 40 45 Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Glu Ser Lys Tyr Gly Pro 50 55 60 Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val 65 70 75 80 Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 85 90 95 Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 100 105 110 Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 115 120 125 Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 130 135 140 Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 145 150 155 160 Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 165 170 175 Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 180 185 190 Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 195 200 205 Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 210 215 220 Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 225 230 235 240 Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 245 250 255 Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 260 265 270 His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Gly Gly 275 280 285 Gly Ser Gly Ser Ala His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln 290 295 300 Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Cys 305 310 315 320 Gln Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly 325 330 335 Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys 340 345 350 Pro Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys 355 360 365 Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu 370 375 380 Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr 385 390 395 400 Gln Ser Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Cys Lys Ser 405 410 415 Pro His Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu 420 425 430 Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro 435 440 445 Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly Ser 450 455 460 Gln Gly Arg Ser Pro Ser Tyr Ala Ser 465 470 <210> 72 <211> 473 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 72 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Lys Gln Leu Glu Lys 1 5 10 15 Arg Leu Phe Arg Leu Phe Ile Glu Trp Leu Ile Ala Gly Gly His Ser 20 25 30 Ser Gly Lys Pro Pro Pro Lys Gly Gly Gly Gly Gly Gly Gly Ser Gly 35 40 45 Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Glu Ser Lys Tyr Gly Pro 50 55 60 Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val 65 70 75 80 Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 85 90 95 Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 100 105 110 Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 115 120 125 Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 130 135 140 Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 145 150 155 160 Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 165 170 175 Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 180 185 190 Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 195 200 205 Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 210 215 220 Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 225 230 235 240 Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 245 250 255 Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 260 265 270 His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Gly Gly 275 280 285 Gly Ser Gly Ser Ala His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln 290 295 300 Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Cys 305 310 315 320 Gln Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly 325 330 335 Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys 340 345 350 Pro Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys 355 360 365 Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu 370 375 380 Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr 385 390 395 400 Gln Ser Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Cys Lys Ser 405 410 415 Pro His Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu 420 425 430 Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro 435 440 445 Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly Ser 450 455 460 Gln Gly Arg Ser Pro Ser Tyr Ala Ser 465 470 <210> 73 <211> 473 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 73 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Lys Gln Leu Glu Lys 1 5 10 15 Arg Leu Val Phe Leu Phe Ile Glu Trp Leu Ile Ala Gly Gly His Ser 20 25 30 Ser Gly Lys Pro Pro Pro Lys Gly Gly Gly Gly Gly Gly Gly Ser Gly 35 40 45 Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Glu Ser Lys Tyr Gly Pro 50 55 60 Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val 65 70 75 80 Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 85 90 95 Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 100 105 110 Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 115 120 125 Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 130 135 140 Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 145 150 155 160 Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 165 170 175 Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 180 185 190 Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 195 200 205 Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 210 215 220 Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 225 230 235 240 Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 245 250 255 Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 260 265 270 His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Gly Gly 275 280 285 Gly Ser Gly Ser Ala His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln 290 295 300 Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Cys 305 310 315 320 Gln Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly 325 330 335 Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys 340 345 350 Pro Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys 355 360 365 Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu 370 375 380 Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr 385 390 395 400 Gln Ser Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Cys Lys Ser 405 410 415 Pro His Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu 420 425 430 Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro 435 440 445 Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly Ser 450 455 460 Gln Gly Arg Ser Pro Ser Tyr Ala Ser 465 470 <210> 74 <211> 473 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 74 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Lys Gln Leu Glu Lys 1 5 10 15 Arg Leu Val Ile Leu Phe Ile Glu Trp Leu Ile Ala Gly Gly His Ser 20 25 30 Ser Gly Lys Pro Pro Pro Lys Gly Gly Gly Gly Gly Gly Gly Ser Gly 35 40 45 Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Glu Ser Lys Tyr Gly Pro 50 55 60 Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val 65 70 75 80 Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 85 90 95 Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 100 105 110 Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 115 120 125 Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 130 135 140 Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 145 150 155 160 Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 165 170 175 Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 180 185 190 Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 195 200 205 Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 210 215 220 Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 225 230 235 240 Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 245 250 255 Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 260 265 270 His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Gly Gly 275 280 285 Gly Ser Gly Ser Ala His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln 290 295 300 Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Cys 305 310 315 320 Gln Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly 325 330 335 Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys 340 345 350 Pro Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys 355 360 365 Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu 370 375 380 Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr 385 390 395 400 Gln Ser Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Cys Lys Ser 405 410 415 Pro His Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu 420 425 430 Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro 435 440 445 Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly Ser 450 455 460 Gln Gly Arg Ser Pro Ser Tyr Ala Ser 465 470 <210> 75 <211> 473 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 75 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Lys Gln Leu Glu Lys 1 5 10 15 Arg Leu Val Arg Ile Phe Ile Glu Trp Leu Ile Ala Gly Gly His Ser 20 25 30 Ser Gly Lys Pro Pro Pro Lys Gly Gly Gly Gly Gly Gly Gly Ser Gly 35 40 45 Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Glu Ser Lys Tyr Gly Pro 50 55 60 Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val 65 70 75 80 Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 85 90 95 Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 100 105 110 Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 115 120 125 Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 130 135 140 Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 145 150 155 160 Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 165 170 175 Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 180 185 190 Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 195 200 205 Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 210 215 220 Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 225 230 235 240 Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 245 250 255 Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 260 265 270 His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Gly Gly 275 280 285 Gly Ser Gly Ser Ala His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln 290 295 300 Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Cys 305 310 315 320 Gln Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly 325 330 335 Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys 340 345 350 Pro Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys 355 360 365 Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu 370 375 380 Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr 385 390 395 400 Gln Ser Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Cys Lys Ser 405 410 415 Pro His Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu 420 425 430 Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro 435 440 445 Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly Ser 450 455 460 Gln Gly Arg Ser Pro Ser Tyr Ala Ser 465 470 <210> 76 <211> 473 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 76 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Lys Gln Leu Glu Lys 1 5 10 15 Arg Leu Val Arg Leu Leu Ile Glu Trp Leu Ile Ala Gly Gly His Ser 20 25 30 Ser Gly Lys Pro Pro Pro Lys Gly Gly Gly Gly Gly Gly Gly Ser Gly 35 40 45 Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Glu Ser Lys Tyr Gly Pro 50 55 60 Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val 65 70 75 80 Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 85 90 95 Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 100 105 110 Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 115 120 125 Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 130 135 140 Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 145 150 155 160 Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 165 170 175 Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 180 185 190 Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 195 200 205 Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 210 215 220 Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 225 230 235 240 Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 245 250 255 Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 260 265 270 His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Gly Gly 275 280 285 Gly Ser Gly Ser Ala His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln 290 295 300 Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Cys 305 310 315 320 Gln Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly 325 330 335 Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys 340 345 350 Pro Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys 355 360 365 Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu 370 375 380 Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr 385 390 395 400 Gln Ser Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Cys Lys Ser 405 410 415 Pro His Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu 420 425 430 Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro 435 440 445 Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly Ser 450 455 460 Gln Gly Arg Ser Pro Ser Tyr Ala Ser 465 470 <210> 77 <211> 473 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 77 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Lys Gln Leu Glu Lys 1 5 10 15 Arg Leu Val Arg Leu Phe His Glu Trp Leu Ile Ala Gly Gly His Ser 20 25 30 Ser Gly Lys Pro Pro Pro Lys Gly Gly Gly Gly Gly Gly Gly Ser Gly 35 40 45 Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Glu Ser Lys Tyr Gly Pro 50 55 60 Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val 65 70 75 80 Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 85 90 95 Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 100 105 110 Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 115 120 125 Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 130 135 140 Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 145 150 155 160 Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 165 170 175 Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 180 185 190 Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 195 200 205 Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 210 215 220 Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 225 230 235 240 Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 245 250 255 Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 260 265 270 His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Gly Gly 275 280 285 Gly Ser Gly Ser Ala His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln 290 295 300 Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Cys 305 310 315 320 Gln Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly 325 330 335 Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys 340 345 350 Pro Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys 355 360 365 Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu 370 375 380 Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr 385 390 395 400 Gln Ser Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Cys Lys Ser 405 410 415 Pro His Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu 420 425 430 Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro 435 440 445 Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly Ser 450 455 460 Gln Gly Arg Ser Pro Ser Tyr Ala Ser 465 470 <210> 78 <211> 473 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 78 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Lys Gln Leu Glu Lys 1 5 10 15 Arg Leu Val Arg Leu Phe Tyr Glu Trp Leu Ile Ala Gly Gly His Ser 20 25 30 Ser Gly Lys Pro Pro Pro Lys Gly Gly Gly Gly Gly Gly Gly Ser Gly 35 40 45 Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Glu Ser Lys Tyr Gly Pro 50 55 60 Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val 65 70 75 80 Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 85 90 95 Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 100 105 110 Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 115 120 125 Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 130 135 140 Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 145 150 155 160 Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 165 170 175 Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 180 185 190 Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 195 200 205 Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 210 215 220 Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 225 230 235 240 Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 245 250 255 Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 260 265 270 His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Gly Gly 275 280 285 Gly Ser Gly Ser Ala His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln 290 295 300 Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Cys 305 310 315 320 Gln Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly 325 330 335 Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys 340 345 350 Pro Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys 355 360 365 Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu 370 375 380 Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr 385 390 395 400 Gln Ser Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Cys Lys Ser 405 410 415 Pro His Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu 420 425 430 Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro 435 440 445 Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly Ser 450 455 460 Gln Gly Arg Ser Pro Ser Tyr Ala Ser 465 470 <210> 79 <211> 473 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 79 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Lys Gln Leu Glu Lys 1 5 10 15 Arg Leu Val Arg Leu Phe Phe Glu Trp Leu Ile Ala Gly Gly His Ser 20 25 30 Ser Gly Lys Pro Pro Pro Lys Gly Gly Gly Gly Gly Gly Gly Ser Gly 35 40 45 Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Glu Ser Lys Tyr Gly Pro 50 55 60 Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val 65 70 75 80 Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 85 90 95 Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 100 105 110 Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 115 120 125 Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 130 135 140 Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 145 150 155 160 Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 165 170 175 Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 180 185 190 Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 195 200 205 Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 210 215 220 Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 225 230 235 240 Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 245 250 255 Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 260 265 270 His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Gly Gly 275 280 285 Gly Ser Gly Ser Ala His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln 290 295 300 Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Cys 305 310 315 320 Gln Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly 325 330 335 Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys 340 345 350 Pro Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys 355 360 365 Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu 370 375 380 Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr 385 390 395 400 Gln Ser Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Cys Lys Ser 405 410 415 Pro His Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu 420 425 430 Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro 435 440 445 Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly Ser 450 455 460 Gln Gly Arg Ser Pro Ser Tyr Ala Ser 465 470 <210> 80 <211> 473 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 80 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Lys Gln Leu Glu Lys 1 5 10 15 Arg Leu Val Arg Leu Phe Ile Leu Trp Leu Ile Ala Gly Gly His Ser 20 25 30 Ser Gly Lys Pro Pro Pro Lys Gly Gly Gly Gly Gly Gly Gly Ser Gly 35 40 45 Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Glu Ser Lys Tyr Gly Pro 50 55 60 Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val 65 70 75 80 Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 85 90 95 Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 100 105 110 Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 115 120 125 Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 130 135 140 Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 145 150 155 160 Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 165 170 175 Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 180 185 190 Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 195 200 205 Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 210 215 220 Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 225 230 235 240 Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 245 250 255 Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 260 265 270 His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Gly Gly 275 280 285 Gly Ser Gly Ser Ala His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln 290 295 300 Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Cys 305 310 315 320 Gln Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly 325 330 335 Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys 340 345 350 Pro Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys 355 360 365 Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu 370 375 380 Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr 385 390 395 400 Gln Ser Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Cys Lys Ser 405 410 415 Pro His Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu 420 425 430 Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro 435 440 445 Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly Ser 450 455 460 Gln Gly Arg Ser Pro Ser Tyr Ala Ser 465 470 <210> 81 <211> 473 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 81 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Lys Gln Leu Glu Lys 1 5 10 15 Arg Leu Val Arg Leu Phe Ile Tyr Trp Leu Ile Ala Gly Gly His Ser 20 25 30 Ser Gly Lys Pro Pro Pro Lys Gly Gly Gly Gly Gly Gly Gly Ser Gly 35 40 45 Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Glu Ser Lys Tyr Gly Pro 50 55 60 Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val 65 70 75 80 Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 85 90 95 Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 100 105 110 Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 115 120 125 Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 130 135 140 Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 145 150 155 160 Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 165 170 175 Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 180 185 190 Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 195 200 205 Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 210 215 220 Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 225 230 235 240 Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 245 250 255 Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 260 265 270 His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Gly Gly 275 280 285 Gly Ser Gly Ser Ala His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln 290 295 300 Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Cys 305 310 315 320 Gln Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly 325 330 335 Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys 340 345 350 Pro Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys 355 360 365 Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu 370 375 380 Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr 385 390 395 400 Gln Ser Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Cys Lys Ser 405 410 415 Pro His Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu 420 425 430 Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro 435 440 445 Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly Ser 450 455 460 Gln Gly Arg Ser Pro Ser Tyr Ala Ser 465 470 <210> 82 <211> 473 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 82 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Lys Gln Leu Glu Lys 1 5 10 15 Arg Leu Val Arg Leu Phe Ile Glu Leu Leu Ile Ala Gly Gly His Ser 20 25 30 Ser Gly Lys Pro Pro Pro Lys Gly Gly Gly Gly Gly Gly Gly Ser Gly 35 40 45 Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Glu Ser Lys Tyr Gly Pro 50 55 60 Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val 65 70 75 80 Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 85 90 95 Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 100 105 110 Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 115 120 125 Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 130 135 140 Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 145 150 155 160 Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 165 170 175 Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 180 185 190 Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 195 200 205 Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 210 215 220 Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 225 230 235 240 Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 245 250 255 Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 260 265 270 His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Gly Gly 275 280 285 Gly Ser Gly Ser Ala His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln 290 295 300 Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Cys 305 310 315 320 Gln Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly 325 330 335 Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys 340 345 350 Pro Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys 355 360 365 Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu 370 375 380 Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr 385 390 395 400 Gln Ser Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Cys Lys Ser 405 410 415 Pro His Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu 420 425 430 Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro 435 440 445 Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly Ser 450 455 460 Gln Gly Arg Ser Pro Ser Tyr Ala Ser 465 470 <210> 83 <211> 472 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 83 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Lys Gln Leu Glu Lys 1 5 10 15 Arg Leu Val Arg Leu Phe Ile Glu Trp Leu Ile Ala Val Gly His Ser 20 25 30 Gly Lys Pro Pro Pro Lys Gly Gly Gly Gly Gly Gly Gly Ser Gly Gly 35 40 45 Gly Gly Ser Gly Gly Gly Gly Ser Ala Glu Ser Lys Tyr Gly Pro Pro 50 55 60 Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val Phe 65 70 75 80 Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 85 90 95 Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val 100 105 110 Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 115 120 125 Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val 130 135 140 Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 145 150 155 160 Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser 165 170 175 Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 180 185 190 Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 195 200 205 Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 210 215 220 Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 225 230 235 240 Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp 245 250 255 Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 260 265 270 Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Gly Gly Gly 275 280 285 Ser Gly Ser Ala His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe 290 295 300 Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Cys Gln 305 310 315 320 Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly Ala 325 330 335 Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys Pro 340 345 350 Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys Gln 355 360 365 Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu Ala 370 375 380 Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr Gln 385 390 395 400 Ser Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Cys Lys Ser Pro 405 410 415 His Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu Pro 420 425 430 Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro Gln 435 440 445 Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly Ser Gln 450 455 460 Gly Arg Ser Pro Ser Tyr Ala Ser 465 470 <210> 84 <211> 473 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 84 His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Ile Gln Leu Asp Glu 1 5 10 15 Glu Ala Val Arg Glu Phe Ile Glu Trp Leu Leu Ala Thr Gly Pro Val 20 25 30 Ser Gly Ala Pro Pro Pro Ser Gly Gly Gly Gly Gly Gly Gly Ser Gly 35 40 45 Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Glu Ser Lys Tyr Gly Pro 50 55 60 Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val 65 70 75 80 Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 85 90 95 Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 100 105 110 Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 115 120 125 Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 130 135 140 Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 145 150 155 160 Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 165 170 175 Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 180 185 190 Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 195 200 205 Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 210 215 220 Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 225 230 235 240 Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 245 250 255 Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 260 265 270 His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Gly Gly 275 280 285 Gly Ser Gly Ser Ala His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln 290 295 300 Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Cys 305 310 315 320 Gln Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly 325 330 335 Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys 340 345 350 Pro Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys 355 360 365 Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu 370 375 380 Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr 385 390 395 400 Gln Ser Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Cys Lys Ser 405 410 415 Pro His Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu 420 425 430 Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro 435 440 445 Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly Ser 450 455 460 Gln Gly Arg Ser Pro Ser Tyr Ala Ser 465 470 <210> 85 <211> 473 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 85 His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Ile Gln Leu Asp Glu 1 5 10 15 Glu Ala Val Gln Glu Phe Ile Glu Trp Leu Leu Ala Thr Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser Gly Gly Gly Gly Gly Gly Gly Ser Gly 35 40 45 Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Glu Ser Lys Tyr Gly Pro 50 55 60 Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val 65 70 75 80 Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 85 90 95 Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 100 105 110 Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 115 120 125 Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 130 135 140 Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 145 150 155 160 Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 165 170 175 Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 180 185 190 Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 195 200 205 Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 210 215 220 Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 225 230 235 240 Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 245 250 255 Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 260 265 270 His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Gly Gly 275 280 285 Gly Ser Gly Ser Ala His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln 290 295 300 Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Cys 305 310 315 320 Gln Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly 325 330 335 Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys 340 345 350 Pro Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys 355 360 365 Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu 370 375 380 Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr 385 390 395 400 Gln Ser Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Cys Lys Ser 405 410 415 Pro His Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu 420 425 430 Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro 435 440 445 Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly Ser 450 455 460 Gln Gly Arg Ser Pro Ser Tyr Ala Ser 465 470 <210> 86 <211> 473 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 86 His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Ile Gln Leu Asp Glu 1 5 10 15 Glu Ala Val Gln Leu Phe Ile Glu Trp Leu Leu Ala Thr Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser Gly Gly Gly Gly Gly Gly Gly Ser Gly 35 40 45 Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Glu Ser Lys Tyr Gly Pro 50 55 60 Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val 65 70 75 80 Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 85 90 95 Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 100 105 110 Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 115 120 125 Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 130 135 140 Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 145 150 155 160 Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 165 170 175 Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 180 185 190 Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 195 200 205 Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 210 215 220 Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 225 230 235 240 Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 245 250 255 Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 260 265 270 His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Gly Gly 275 280 285 Gly Ser Gly Ser Ala His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln 290 295 300 Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Cys 305 310 315 320 Gln Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly 325 330 335 Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys 340 345 350 Pro Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys 355 360 365 Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu 370 375 380 Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr 385 390 395 400 Gln Ser Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Cys Lys Ser 405 410 415 Pro His Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu 420 425 430 Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro 435 440 445 Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly Ser 450 455 460 Gln Gly Arg Ser Pro Ser Tyr Ala Ser 465 470 <210> 87 <211> 473 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 87 His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Ile Gln Leu Asp Glu 1 5 10 15 Glu Ala Val Gln Leu Phe Ile Glu Trp Leu Leu Ala Thr Gly Pro Val 20 25 30 Ser Gly Ala Pro Pro Pro Ser Gly Gly Gly Gly Gly Gly Gly Ser Gly 35 40 45 Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Glu Ser Lys Tyr Gly Pro 50 55 60 Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val 65 70 75 80 Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 85 90 95 Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 100 105 110 Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 115 120 125 Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 130 135 140 Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 145 150 155 160 Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 165 170 175 Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 180 185 190 Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 195 200 205 Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 210 215 220 Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 225 230 235 240 Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 245 250 255 Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 260 265 270 His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Gly Gly 275 280 285 Gly Ser Gly Ser Ala His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln 290 295 300 Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Cys 305 310 315 320 Gln Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly 325 330 335 Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys 340 345 350 Pro Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys 355 360 365 Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu 370 375 380 Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr 385 390 395 400 Gln Ser Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Cys Lys Ser 405 410 415 Pro His Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu 420 425 430 Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro 435 440 445 Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly Ser 450 455 460 Gln Gly Arg Ser Pro Ser Tyr Ala Ser 465 470 <210> 88 <211> 473 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 88 His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Ile Leu Leu Asp Glu 1 5 10 15 Glu Ala Val Arg Glu Phe Ile Glu Trp Leu Leu Ala Thr Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser Gly Gly Gly Gly Gly Gly Gly Ser Gly 35 40 45 Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Glu Ser Lys Tyr Gly Pro 50 55 60 Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val 65 70 75 80 Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 85 90 95 Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 100 105 110 Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 115 120 125 Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 130 135 140 Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 145 150 155 160 Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 165 170 175 Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 180 185 190 Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 195 200 205 Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 210 215 220 Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 225 230 235 240 Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 245 250 255 Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 260 265 270 His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Gly Gly 275 280 285 Gly Ser Gly Ser Ala His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln 290 295 300 Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Cys 305 310 315 320 Gln Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly 325 330 335 Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys 340 345 350 Pro Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys 355 360 365 Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu 370 375 380 Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr 385 390 395 400 Gln Ser Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Cys Lys Ser 405 410 415 Pro His Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu 420 425 430 Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro 435 440 445 Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly Ser 450 455 460 Gln Gly Arg Ser Pro Ser Tyr Ala Ser 465 470 <210> 89 <211> 473 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 89 His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Ile Leu Leu Asp Glu 1 5 10 15 Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Leu Ala Thr Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser Gly Gly Gly Gly Gly Gly Gly Ser Gly 35 40 45 Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Glu Ser Lys Tyr Gly Pro 50 55 60 Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val 65 70 75 80 Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 85 90 95 Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 100 105 110 Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 115 120 125 Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 130 135 140 Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 145 150 155 160 Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 165 170 175 Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 180 185 190 Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 195 200 205 Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 210 215 220 Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 225 230 235 240 Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 245 250 255 Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 260 265 270 His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Gly Gly 275 280 285 Gly Ser Gly Ser Ala His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln 290 295 300 Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Cys 305 310 315 320 Gln Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly 325 330 335 Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys 340 345 350 Pro Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys 355 360 365 Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu 370 375 380 Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr 385 390 395 400 Gln Ser Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Cys Lys Ser 405 410 415 Pro His Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu 420 425 430 Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro 435 440 445 Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly Ser 450 455 460 Gln Gly Arg Ser Pro Ser Tyr Ala Ser 465 470 <210> 90 <211> 473 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 90 His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Ile Leu Leu Asp Glu 1 5 10 15 Glu Ala Val Gln Leu Phe Ile Glu Trp Leu Leu Ala Thr Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser Gly Gly Gly Gly Gly Gly Gly Ser Gly 35 40 45 Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Glu Ser Lys Tyr Gly Pro 50 55 60 Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val 65 70 75 80 Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 85 90 95 Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 100 105 110 Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 115 120 125 Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 130 135 140 Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 145 150 155 160 Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 165 170 175 Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 180 185 190 Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 195 200 205 Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 210 215 220 Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 225 230 235 240 Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 245 250 255 Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 260 265 270 His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Gly Gly 275 280 285 Gly Ser Gly Ser Ala His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln 290 295 300 Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Cys 305 310 315 320 Gln Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly 325 330 335 Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys 340 345 350 Pro Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys 355 360 365 Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu 370 375 380 Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr 385 390 395 400 Gln Ser Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Cys Lys Ser 405 410 415 Pro His Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu 420 425 430 Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro 435 440 445 Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly Ser 450 455 460 Gln Gly Arg Ser Pro Ser Tyr Ala Ser 465 470 <210> 91 <211> 473 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 91 His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Ile Leu Leu Asp Glu 1 5 10 15 Glu Ala Val Gln Leu Phe Ile Glu Trp Leu Leu Ala Thr Gly Pro Val 20 25 30 Ser Gly Ala Pro Pro Pro Ser Gly Gly Gly Gly Gly Gly Gly Ser Gly 35 40 45 Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Glu Ser Lys Tyr Gly Pro 50 55 60 Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val 65 70 75 80 Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 85 90 95 Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 100 105 110 Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 115 120 125 Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 130 135 140 Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 145 150 155 160 Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 165 170 175 Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 180 185 190 Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 195 200 205 Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 210 215 220 Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 225 230 235 240 Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 245 250 255 Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 260 265 270 His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Gly Gly 275 280 285 Gly Ser Gly Ser Ala His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln 290 295 300 Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Cys 305 310 315 320 Gln Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly 325 330 335 Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys 340 345 350 Pro Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys 355 360 365 Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu 370 375 380 Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr 385 390 395 400 Gln Ser Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Cys Lys Ser 405 410 415 Pro His Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu 420 425 430 Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro 435 440 445 Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly Ser 450 455 460 Gln Gly Arg Ser Pro Ser Tyr Ala Ser 465 470 <210> 92 <211> 473 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 92 His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Ile Gln Leu Glu Glu 1 5 10 15 Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Leu Ala Thr Gly Pro Val 20 25 30 Ser Gly Ala Pro Pro Pro Ser Gly Gly Gly Gly Gly Gly Gly Ser Gly 35 40 45 Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Glu Ser Lys Tyr Gly Pro 50 55 60 Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val 65 70 75 80 Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 85 90 95 Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 100 105 110 Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 115 120 125 Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 130 135 140 Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 145 150 155 160 Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 165 170 175 Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 180 185 190 Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 195 200 205 Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 210 215 220 Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 225 230 235 240 Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 245 250 255 Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 260 265 270 His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Gly Gly 275 280 285 Gly Ser Gly Ser Ala His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln 290 295 300 Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Cys 305 310 315 320 Gln Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly 325 330 335 Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys 340 345 350 Pro Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys 355 360 365 Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu 370 375 380 Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr 385 390 395 400 Gln Ser Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Cys Lys Ser 405 410 415 Pro His Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu 420 425 430 Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro 435 440 445 Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly Ser 450 455 460 Gln Gly Arg Ser Pro Ser Tyr Ala Ser 465 470 <210> 93 <211> 473 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 93 His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Ile Gln Leu Glu Glu 1 5 10 15 Glu Ala Val Gln Glu Phe Ile Glu Trp Leu Leu Ala Thr Gly Pro Val 20 25 30 Ser Gly Ala Pro Pro Pro Ser Gly Gly Gly Gly Gly Gly Gly Ser Gly 35 40 45 Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Glu Ser Lys Tyr Gly Pro 50 55 60 Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val 65 70 75 80 Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 85 90 95 Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 100 105 110 Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 115 120 125 Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 130 135 140 Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 145 150 155 160 Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 165 170 175 Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 180 185 190 Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 195 200 205 Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 210 215 220 Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 225 230 235 240 Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 245 250 255 Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 260 265 270 His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Gly Gly 275 280 285 Gly Ser Gly Ser Ala His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln 290 295 300 Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Cys 305 310 315 320 Gln Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly 325 330 335 Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys 340 345 350 Pro Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys 355 360 365 Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu 370 375 380 Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr 385 390 395 400 Gln Ser Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Cys Lys Ser 405 410 415 Pro His Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu 420 425 430 Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro 435 440 445 Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly Ser 450 455 460 Gln Gly Arg Ser Pro Ser Tyr Ala Ser 465 470 <210> 94 <211> 473 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 94 His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Ile Gln Leu Glu Glu 1 5 10 15 Glu Ala Val Gln Leu Phe Ile Glu Trp Leu Leu Ala Thr Gly Pro Val 20 25 30 Ser Gly Ala Pro Pro Pro Ser Gly Gly Gly Gly Gly Gly Gly Ser Gly 35 40 45 Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Glu Ser Lys Tyr Gly Pro 50 55 60 Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val 65 70 75 80 Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 85 90 95 Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 100 105 110 Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 115 120 125 Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 130 135 140 Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 145 150 155 160 Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 165 170 175 Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 180 185 190 Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 195 200 205 Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 210 215 220 Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 225 230 235 240 Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 245 250 255 Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 260 265 270 His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Gly Gly 275 280 285 Gly Ser Gly Ser Ala His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln 290 295 300 Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Cys 305 310 315 320 Gln Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly 325 330 335 Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys 340 345 350 Pro Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys 355 360 365 Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu 370 375 380 Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr 385 390 395 400 Gln Ser Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Cys Lys Ser 405 410 415 Pro His Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu 420 425 430 Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro 435 440 445 Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly Ser 450 455 460 Gln Gly Arg Ser Pro Ser Tyr Ala Ser 465 470 <210> 95 <211> 473 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 95 His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Ile Leu Leu Glu Glu 1 5 10 15 Glu Ala Val Arg Glu Phe Ile Glu Trp Leu Leu Ala Thr Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser Gly Gly Gly Gly Gly Gly Gly Ser Gly 35 40 45 Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Glu Ser Lys Tyr Gly Pro 50 55 60 Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val 65 70 75 80 Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 85 90 95 Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 100 105 110 Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 115 120 125 Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 130 135 140 Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 145 150 155 160 Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 165 170 175 Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 180 185 190 Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 195 200 205 Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 210 215 220 Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 225 230 235 240 Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 245 250 255 Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 260 265 270 His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Gly Gly 275 280 285 Gly Ser Gly Ser Ala His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln 290 295 300 Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Cys 305 310 315 320 Gln Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly 325 330 335 Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys 340 345 350 Pro Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys 355 360 365 Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu 370 375 380 Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr 385 390 395 400 Gln Ser Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Cys Lys Ser 405 410 415 Pro His Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu 420 425 430 Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro 435 440 445 Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly Ser 450 455 460 Gln Gly Arg Ser Pro Ser Tyr Ala Ser 465 470 <210> 96 <211> 473 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 96 His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Ile Leu Leu Glu Glu 1 5 10 15 Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Leu Ala Thr Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser Gly Gly Gly Gly Gly Gly Gly Ser Gly 35 40 45 Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Glu Ser Lys Tyr Gly Pro 50 55 60 Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val 65 70 75 80 Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 85 90 95 Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 100 105 110 Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 115 120 125 Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 130 135 140 Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 145 150 155 160 Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 165 170 175 Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 180 185 190 Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 195 200 205 Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 210 215 220 Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 225 230 235 240 Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 245 250 255 Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 260 265 270 His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Gly Gly 275 280 285 Gly Ser Gly Ser Ala His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln 290 295 300 Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Cys 305 310 315 320 Gln Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly 325 330 335 Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys 340 345 350 Pro Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys 355 360 365 Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu 370 375 380 Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr 385 390 395 400 Gln Ser Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Cys Lys Ser 405 410 415 Pro His Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu 420 425 430 Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro 435 440 445 Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly Ser 450 455 460 Gln Gly Arg Ser Pro Ser Tyr Ala Ser 465 470 <210> 97 <211> 473 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 97 His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Ile Leu Leu Glu Glu 1 5 10 15 Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Leu Ala Thr Gly Pro Val 20 25 30 Ser Gly Ala Pro Pro Pro Ser Gly Gly Gly Gly Gly Gly Gly Ser Gly 35 40 45 Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Glu Ser Lys Tyr Gly Pro 50 55 60 Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val 65 70 75 80 Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 85 90 95 Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 100 105 110 Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 115 120 125 Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 130 135 140 Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 145 150 155 160 Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 165 170 175 Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 180 185 190 Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 195 200 205 Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 210 215 220 Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 225 230 235 240 Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 245 250 255 Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 260 265 270 His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Gly Gly 275 280 285 Gly Ser Gly Ser Ala His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln 290 295 300 Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Cys 305 310 315 320 Gln Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly 325 330 335 Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys 340 345 350 Pro Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys 355 360 365 Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu 370 375 380 Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr 385 390 395 400 Gln Ser Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Cys Lys Ser 405 410 415 Pro His Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu 420 425 430 Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro 435 440 445 Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly Ser 450 455 460 Gln Gly Arg Ser Pro Ser Tyr Ala Ser 465 470 <210> 98 <211> 474 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 98 Gly His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu 1 5 10 15 Glu Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro 20 25 30 Ser Ser Gly Ala Pro Pro Pro Ser Gly Gly Gly Gly Gly Gly Gly Ser 35 40 45 Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Glu Ser Lys Tyr Gly 50 55 60 Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser 65 70 75 80 Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 85 90 95 Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro 100 105 110 Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 115 120 125 Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val 130 135 140 Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 145 150 155 160 Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr 165 170 175 Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 180 185 190 Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 195 200 205 Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 210 215 220 Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 225 230 235 240 Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser 245 250 255 Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 260 265 270 Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Gly 275 280 285 Gly Gly Ser Gly Ser Ala His Pro Ile Pro Asp Ser Ser Pro Leu Leu 290 295 300 Gln Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala 305 310 315 320 Cys Gln Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly 325 330 335 Gly Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu 340 345 350 Lys Pro Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu 355 360 365 Cys Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro 370 375 380 Glu Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val 385 390 395 400 Tyr Gln Ser Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Cys Lys 405 410 415 Ser Pro His Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro 420 425 430 Leu Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala 435 440 445 Pro Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly 450 455 460 Ser Gln Gly Arg Ser Pro Ser Tyr Ala Ser 465 470 <210> 99 <211> 473 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 99 His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Leu Glu Glu 1 5 10 15 Glu Ala Val Gln Leu Phe Ile Glu Trp Leu Leu Asn Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Glu Gly Gly Gly Gly Gly Gly Gly Ser Gly 35 40 45 Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Glu Ser Lys Tyr Gly Pro 50 55 60 Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val 65 70 75 80 Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 85 90 95 Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 100 105 110 Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 115 120 125 Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 130 135 140 Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 145 150 155 160 Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 165 170 175 Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 180 185 190 Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 195 200 205 Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 210 215 220 Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 225 230 235 240 Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 245 250 255 Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 260 265 270 His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Gly Gly 275 280 285 Gly Ser Gly Ser Ala His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln 290 295 300 Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Cys 305 310 315 320 Gln Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly 325 330 335 Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys 340 345 350 Pro Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys 355 360 365 Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu 370 375 380 Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr 385 390 395 400 Gln Ser Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Cys Lys Ser 405 410 415 Pro His Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu 420 425 430 Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro 435 440 445 Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly Ser 450 455 460 Gln Gly Arg Ser Pro Ser Tyr Ala Ser 465 470 <210> 100 <211> 473 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 100 His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Leu Glu Glu 1 5 10 15 Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Leu Ala Thr Gly Pro Ser 20 25 30 Ser Gly Glu Pro Pro Pro Glu Gly Gly Gly Gly Gly Gly Gly Ser Gly 35 40 45 Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Glu Ser Lys Tyr Gly Pro 50 55 60 Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val 65 70 75 80 Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 85 90 95 Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 100 105 110 Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 115 120 125 Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 130 135 140 Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 145 150 155 160 Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 165 170 175 Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 180 185 190 Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 195 200 205 Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 210 215 220 Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 225 230 235 240 Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 245 250 255 Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 260 265 270 His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Gly Gly 275 280 285 Gly Ser Gly Ser Ala His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln 290 295 300 Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Cys 305 310 315 320 Gln Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly 325 330 335 Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys 340 345 350 Pro Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys 355 360 365 Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu 370 375 380 Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr 385 390 395 400 Gln Ser Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Cys Lys Ser 405 410 415 Pro His Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu 420 425 430 Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro 435 440 445 Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly Ser 450 455 460 Gln Gly Arg Ser Pro Ser Tyr Ala Ser 465 470 <210> 101 <211> 473 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 101 His Ala Gln Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Leu Glu Ser 1 5 10 15 Arg Arg Ala Gln Glu Phe Ile Glu Trp Leu Leu Ala Thr Gly Pro Glu 20 25 30 Ser Gly Ala Pro Pro Pro Ser Gly Gly Gly Gly Gly Gly Gly Ser Gly 35 40 45 Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Glu Ser Lys Tyr Gly Pro 50 55 60 Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val 65 70 75 80 Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 85 90 95 Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 100 105 110 Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 115 120 125 Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 130 135 140 Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 145 150 155 160 Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 165 170 175 Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 180 185 190 Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 195 200 205 Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 210 215 220 Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 225 230 235 240 Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 245 250 255 Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 260 265 270 His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Gly Gly 275 280 285 Gly Ser Gly Ser Ala His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln 290 295 300 Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Cys 305 310 315 320 Gln Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly 325 330 335 Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys 340 345 350 Pro Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys 355 360 365 Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu 370 375 380 Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr 385 390 395 400 Gln Ser Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Cys Lys Ser 405 410 415 Pro His Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu 420 425 430 Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro 435 440 445 Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly Ser 450 455 460 Gln Gly Arg Ser Pro Ser Tyr Ala Ser 465 470 <210> 102 <211> 473 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 102 His Ser Gln Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Leu Glu Ser 1 5 10 15 Arg Arg Ala Arg Arg Phe Ile Glu Trp Leu Leu Ala Thr Gly Pro Glu 20 25 30 Ser Gly Ala Pro Pro Pro Ser Gly Gly Gly Gly Gly Gly Gly Ser Gly 35 40 45 Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Glu Ser Lys Tyr Gly Pro 50 55 60 Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val 65 70 75 80 Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 85 90 95 Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 100 105 110 Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 115 120 125 Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 130 135 140 Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 145 150 155 160 Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 165 170 175 Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 180 185 190 Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 195 200 205 Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 210 215 220 Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 225 230 235 240 Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 245 250 255 Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 260 265 270 His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Gly Gly 275 280 285 Gly Ser Gly Ser Ala His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln 290 295 300 Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Cys 305 310 315 320 Gln Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly 325 330 335 Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys 340 345 350 Pro Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys 355 360 365 Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu 370 375 380 Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr 385 390 395 400 Gln Ser Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Cys Lys Ser 405 410 415 Pro His Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu 420 425 430 Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro 435 440 445 Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly Ser 450 455 460 Gln Gly Arg Ser Pro Ser Tyr Ala Ser 465 470 <210> 103 <211> 473 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 103 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Gln Leu Leu Glu Lys 1 5 10 15 Arg Ala Ala His Leu Phe Ile Glu Trp Leu Ile Lys Gly Gly His Ser 20 25 30 Lys Gly Lys Pro Pro Pro Lys Gly Gly Gly Gly Gly Gly Gly Ser Gly 35 40 45 Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Glu Ser Lys Tyr Gly Pro 50 55 60 Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val 65 70 75 80 Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 85 90 95 Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 100 105 110 Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 115 120 125 Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 130 135 140 Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 145 150 155 160 Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 165 170 175 Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 180 185 190 Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 195 200 205 Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 210 215 220 Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 225 230 235 240 Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 245 250 255 Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 260 265 270 His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Gly Gly 275 280 285 Gly Ser Gly Ser Ala His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln 290 295 300 Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Cys 305 310 315 320 Gln Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly 325 330 335 Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys 340 345 350 Pro Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys 355 360 365 Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu 370 375 380 Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr 385 390 395 400 Gln Ser Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Cys Lys Ser 405 410 415 Pro His Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu 420 425 430 Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro 435 440 445 Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly Ser 450 455 460 Gln Gly Arg Ser Pro Ser Tyr Ala Ser 465 470 <210> 104 <211> 473 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 104 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Gln Leu Leu Glu Lys 1 5 10 15 Arg Leu Ala His Leu Phe Ile Glu Trp Leu Ile Lys Gly Gly His Ser 20 25 30 Ser Gly Lys Pro Pro Pro Lys Gly Gly Gly Gly Gly Gly Gly Ser Gly 35 40 45 Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Glu Ser Lys Tyr Gly Pro 50 55 60 Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val 65 70 75 80 Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 85 90 95 Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 100 105 110 Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 115 120 125 Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 130 135 140 Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 145 150 155 160 Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 165 170 175 Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 180 185 190 Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 195 200 205 Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 210 215 220 Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 225 230 235 240 Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 245 250 255 Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 260 265 270 His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Gly Gly 275 280 285 Gly Ser Gly Ser Ala His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln 290 295 300 Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Cys 305 310 315 320 Gln Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly 325 330 335 Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys 340 345 350 Pro Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys 355 360 365 Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu 370 375 380 Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr 385 390 395 400 Gln Ser Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Cys Lys Ser 405 410 415 Pro His Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu 420 425 430 Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro 435 440 445 Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly Ser 450 455 460 Gln Gly Arg Ser Pro Ser Tyr Ala Ser 465 470 <210> 105 <211> 473 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 105 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Gln Leu Leu Glu Glu 1 5 10 15 Arg Leu Ala His Leu Phe Ile Glu Trp Leu Ile Lys Gly Gly His Ser 20 25 30 Ser Ile Lys Pro Pro Pro Lys Gly Gly Gly Gly Gly Gly Gly Ser Gly 35 40 45 Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Glu Ser Lys Tyr Gly Pro 50 55 60 Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val 65 70 75 80 Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 85 90 95 Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 100 105 110 Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 115 120 125 Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 130 135 140 Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 145 150 155 160 Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 165 170 175 Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 180 185 190 Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 195 200 205 Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 210 215 220 Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 225 230 235 240 Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 245 250 255 Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 260 265 270 His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Gly Gly 275 280 285 Gly Ser Gly Ser Ala His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln 290 295 300 Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Cys 305 310 315 320 Gln Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly 325 330 335 Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys 340 345 350 Pro Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys 355 360 365 Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu 370 375 380 Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr 385 390 395 400 Gln Ser Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Cys Lys Ser 405 410 415 Pro His Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu 420 425 430 Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro 435 440 445 Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly Ser 450 455 460 Gln Gly Arg Ser Pro Ser Tyr Ala Ser 465 470 <210> 106 <211> 473 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 106 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Gln Leu Leu Glu Glu 1 5 10 15 Arg Leu Ala His Leu Phe Ile Glu Trp Leu Ile Ala Gly Gly His Ser 20 25 30 Ser Gly Arg Pro Pro Pro Lys Gly Gly Gly Gly Gly Gly Gly Ser Gly 35 40 45 Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Glu Ser Lys Tyr Gly Pro 50 55 60 Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val 65 70 75 80 Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 85 90 95 Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 100 105 110 Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 115 120 125 Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 130 135 140 Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 145 150 155 160 Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 165 170 175 Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 180 185 190 Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 195 200 205 Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 210 215 220 Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 225 230 235 240 Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 245 250 255 Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 260 265 270 His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Gly Gly 275 280 285 Gly Ser Gly Ser Ala His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln 290 295 300 Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Cys 305 310 315 320 Gln Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly 325 330 335 Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys 340 345 350 Pro Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys 355 360 365 Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu 370 375 380 Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr 385 390 395 400 Gln Ser Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Cys Lys Ser 405 410 415 Pro His Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu 420 425 430 Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro 435 440 445 Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly Ser 450 455 460 Gln Gly Arg Ser Pro Ser Tyr Ala Ser 465 470 <210> 107 <211> 473 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 107 Tyr Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Gln Leu Leu Glu Glu 1 5 10 15 Arg Leu Ala His Leu Phe Ile Glu Trp Leu Ile Ala Gly Gly His Ser 20 25 30 Lys Ile Arg Pro Pro Pro Lys Gly Gly Gly Gly Gly Gly Gly Ser Gly 35 40 45 Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Glu Ser Lys Tyr Gly Pro 50 55 60 Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val 65 70 75 80 Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 85 90 95 Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 100 105 110 Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 115 120 125 Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 130 135 140 Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 145 150 155 160 Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 165 170 175 Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 180 185 190 Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 195 200 205 Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 210 215 220 Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 225 230 235 240 Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 245 250 255 Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 260 265 270 His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Gly Gly 275 280 285 Gly Ser Gly Ser Ala His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln 290 295 300 Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Cys 305 310 315 320 Gln Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly 325 330 335 Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys 340 345 350 Pro Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys 355 360 365 Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu 370 375 380 Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr 385 390 395 400 Gln Ser Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Cys Lys Ser 405 410 415 Pro His Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu 420 425 430 Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro 435 440 445 Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly Ser 450 455 460 Gln Gly Arg Ser Pro Ser Tyr Ala Ser 465 470 <210> 108 <211> 473 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 108 Tyr Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Gln Leu Leu Glu Glu 1 5 10 15 Arg Leu Val His Leu Phe Ile Glu Trp Leu Ile Ala Gly Gly His Ser 20 25 30 Lys Ile Lys Pro Pro Pro Lys Gly Gly Gly Gly Gly Gly Gly Ser Gly 35 40 45 Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Glu Ser Lys Tyr Gly Pro 50 55 60 Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val 65 70 75 80 Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 85 90 95 Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 100 105 110 Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 115 120 125 Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 130 135 140 Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 145 150 155 160 Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 165 170 175 Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 180 185 190 Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 195 200 205 Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 210 215 220 Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 225 230 235 240 Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 245 250 255 Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 260 265 270 His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Gly Gly 275 280 285 Gly Ser Gly Ser Ala His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln 290 295 300 Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Cys 305 310 315 320 Gln Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly 325 330 335 Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys 340 345 350 Pro Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys 355 360 365 Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu 370 375 380 Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr 385 390 395 400 Gln Ser Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Cys Lys Ser 405 410 415 Pro His Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu 420 425 430 Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro 435 440 445 Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly Ser 450 455 460 Gln Gly Arg Ser Pro Ser Tyr Ala Ser 465 470 <210> 109 <211> 473 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 109 Tyr Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Gln Leu Leu Glu Lys 1 5 10 15 Glu Leu Ala His Leu Phe Ile Glu Trp Leu Ile Ala Gly Gly His Lys 20 25 30 Ser Gly Arg Pro Ser Pro Lys Gly Gly Gly Gly Gly Gly Gly Ser Gly 35 40 45 Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Glu Ser Lys Tyr Gly Pro 50 55 60 Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val 65 70 75 80 Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 85 90 95 Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 100 105 110 Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 115 120 125 Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 130 135 140 Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 145 150 155 160 Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 165 170 175 Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 180 185 190 Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 195 200 205 Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 210 215 220 Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 225 230 235 240 Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 245 250 255 Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 260 265 270 His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Gly Gly 275 280 285 Gly Ser Gly Ser Ala His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln 290 295 300 Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Cys 305 310 315 320 Gln Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly 325 330 335 Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys 340 345 350 Pro Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys 355 360 365 Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu 370 375 380 Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr 385 390 395 400 Gln Ser Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Cys Lys Ser 405 410 415 Pro His Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu 420 425 430 Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro 435 440 445 Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly Ser 450 455 460 Gln Gly Arg Ser Pro Ser Tyr Ala Ser 465 470 <210> 110 <211> 473 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 110 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Gln Leu Leu Glu Lys 1 5 10 15 Arg Leu Ala His Leu Phe Ile Glu Trp Leu Leu Ala Gly Gly Pro Ser 20 25 30 Ser Gly Lys Pro Pro Pro Lys Gly Gly Gly Gly Gly Gly Gly Ser Gly 35 40 45 Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Glu Ser Lys Tyr Gly Pro 50 55 60 Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val 65 70 75 80 Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 85 90 95 Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 100 105 110 Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 115 120 125 Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 130 135 140 Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 145 150 155 160 Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 165 170 175 Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 180 185 190 Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 195 200 205 Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 210 215 220 Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 225 230 235 240 Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 245 250 255 Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 260 265 270 His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Gly Gly 275 280 285 Gly Ser Gly Ser Ala His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln 290 295 300 Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Cys 305 310 315 320 Gln Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly 325 330 335 Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys 340 345 350 Pro Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys 355 360 365 Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu 370 375 380 Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr 385 390 395 400 Gln Ser Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Cys Lys Ser 405 410 415 Pro His Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu 420 425 430 Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro 435 440 445 Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly Ser 450 455 460 Gln Gly Arg Ser Pro Ser Tyr Ala Ser 465 470 <210> 111 <211> 473 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 111 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Gln Leu Leu Glu Lys 1 5 10 15 Arg Ala Ala His Leu Phe Ile Glu Trp Leu Ile Ala Gly Gly Pro Ser 20 25 30 Lys Gly Lys Pro Pro Pro Lys Gly Gly Gly Gly Gly Gly Gly Ser Gly 35 40 45 Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Glu Ser Lys Tyr Gly Pro 50 55 60 Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val 65 70 75 80 Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 85 90 95 Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 100 105 110 Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 115 120 125 Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 130 135 140 Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 145 150 155 160 Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 165 170 175 Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 180 185 190 Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 195 200 205 Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 210 215 220 Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 225 230 235 240 Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 245 250 255 Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 260 265 270 His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Gly Gly 275 280 285 Gly Ser Gly Ser Ala His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln 290 295 300 Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Cys 305 310 315 320 Gln Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly 325 330 335 Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys 340 345 350 Pro Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys 355 360 365 Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu 370 375 380 Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr 385 390 395 400 Gln Ser Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Cys Lys Ser 405 410 415 Pro His Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu 420 425 430 Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro 435 440 445 Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly Ser 450 455 460 Gln Gly Arg Ser Pro Ser Tyr Ala Ser 465 470 <210> 112 <211> 473 <212> PRT <213> Artificial Sequence <220> <223> Fusion protein <400> 112 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Gln Leu Leu Glu Lys 1 5 10 15 Arg Leu Ala His Leu Phe Ile Glu Trp Leu Leu Ala Gly Gly Pro Ser 20 25 30 Ser Gly Arg Pro Pro Pro Lys Gly Gly Gly Gly Gly Gly Gly Ser Gly 35 40 45 Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Glu Ser Lys Tyr Gly Pro 50 55 60 Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val 65 70 75 80 Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 85 90 95 Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 100 105 110 Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 115 120 125 Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 130 135 140 Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 145 150 155 160 Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 165 170 175 Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 180 185 190 Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 195 200 205 Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 210 215 220 Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 225 230 235 240 Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 245 250 255 Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 260 265 270 His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Gly Gly 275 280 285 Gly Ser Gly Ser Ala His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln 290 295 300 Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Cys 305 310 315 320 Gln Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly 325 330 335 Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys 340 345 350 Pro Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys 355 360 365 Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu 370 375 380 Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr 385 390 395 400 Gln Ser Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Cys Lys Ser 405 410 415 Pro His Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu 420 425 430 Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro 435 440 445 Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly Ser 450 455 460 Gln Gly Arg Ser Pro Ser Tyr Ala Ser 465 470 <210> 113 <211> 473 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 113 Tyr Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Gln Leu Leu Glu Lys 1 5 10 15 Arg Leu Ala His Leu Phe Ile Glu Trp Leu Ile Lys Gly Gly His Ser 20 25 30 Ser Ile Arg Pro Pro Pro Lys Gly Gly Gly Gly Gly Gly Gly Ser Gly 35 40 45 Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Glu Ser Lys Tyr Gly Pro 50 55 60 Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val 65 70 75 80 Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 85 90 95 Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 100 105 110 Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 115 120 125 Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 130 135 140 Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 145 150 155 160 Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 165 170 175 Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 180 185 190 Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 195 200 205 Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 210 215 220 Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 225 230 235 240 Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 245 250 255 Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 260 265 270 His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Gly Gly 275 280 285 Gly Ser Gly Ser Ala His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln 290 295 300 Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Cys 305 310 315 320 Gln Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly 325 330 335 Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys 340 345 350 Pro Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys 355 360 365 Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu 370 375 380 Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr 385 390 395 400 Gln Ser Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Cys Lys Ser 405 410 415 Pro His Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu 420 425 430 Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro 435 440 445 Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly Ser 450 455 460 Gln Gly Arg Ser Pro Ser Tyr Ala Ser 465 470 <210> 114 <211> 474 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 114 Gly His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Gln Leu Leu Glu 1 5 10 15 Lys Arg Leu Val His Leu Phe Ile Glu Trp Leu Ile Ala Gly Gly His 20 25 30 Ser Ser Gly Lys Leu Pro Pro Lys Gly Gly Gly Gly Gly Gly Gly Ser 35 40 45 Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Glu Ser Lys Tyr Gly 50 55 60 Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser 65 70 75 80 Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 85 90 95 Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro 100 105 110 Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 115 120 125 Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val 130 135 140 Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 145 150 155 160 Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr 165 170 175 Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 180 185 190 Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 195 200 205 Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 210 215 220 Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 225 230 235 240 Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser 245 250 255 Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 260 265 270 Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Gly 275 280 285 Gly Gly Ser Gly Ser Ala His Pro Ile Pro Asp Ser Ser Pro Leu Leu 290 295 300 Gln Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala 305 310 315 320 Cys Gln Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly 325 330 335 Gly Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu 340 345 350 Lys Pro Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu 355 360 365 Cys Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro 370 375 380 Glu Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val 385 390 395 400 Tyr Gln Ser Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Cys Lys 405 410 415 Ser Pro His Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro 420 425 430 Leu Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala 435 440 445 Pro Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly 450 455 460 Ser Gln Gly Arg Ser Pro Ser Tyr Ala Ser 465 470 <210> 115 <211> 473 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 115 Tyr Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Gln Leu Leu Glu Lys 1 5 10 15 Arg Leu Ala His Leu Phe Ile Glu Trp Leu Ile Lys Gly Gly His Ser 20 25 30 Ser Ile Lys Pro Pro Pro Lys Gly Gly Gly Gly Gly Gly Gly Ser Gly 35 40 45 Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Glu Ser Lys Tyr Gly Pro 50 55 60 Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val 65 70 75 80 Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 85 90 95 Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 100 105 110 Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 115 120 125 Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 130 135 140 Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 145 150 155 160 Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 165 170 175 Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 180 185 190 Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 195 200 205 Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 210 215 220 Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 225 230 235 240 Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 245 250 255 Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 260 265 270 His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Gly Gly 275 280 285 Gly Ser Gly Ser Ala His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln 290 295 300 Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Cys 305 310 315 320 Gln Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly 325 330 335 Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys 340 345 350 Pro Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys 355 360 365 Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu 370 375 380 Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr 385 390 395 400 Gln Ser Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Cys Lys Ser 405 410 415 Pro His Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu 420 425 430 Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro 435 440 445 Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly Ser 450 455 460 Gln Gly Arg Ser Pro Ser Tyr Ala Ser 465 470 <210> 116 <211> 473 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 116 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Gln Leu Leu Glu Lys 1 5 10 15 Arg Leu Ala His Leu Phe Ile Glu Trp Leu Ile Ala Gly Gly Pro Ser 20 25 30 Lys Gly Lys Pro Pro Pro Lys Gly Gly Gly Gly Gly Gly Gly Ser Gly 35 40 45 Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Glu Ser Lys Tyr Gly Pro 50 55 60 Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val 65 70 75 80 Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 85 90 95 Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 100 105 110 Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 115 120 125 Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 130 135 140 Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 145 150 155 160 Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 165 170 175 Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 180 185 190 Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 195 200 205 Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 210 215 220 Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 225 230 235 240 Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 245 250 255 Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 260 265 270 His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Gly Gly 275 280 285 Gly Ser Gly Ser Ala His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln 290 295 300 Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Cys 305 310 315 320 Gln Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly 325 330 335 Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys 340 345 350 Pro Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys 355 360 365 Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu 370 375 380 Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr 385 390 395 400 Gln Ser Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Cys Lys Ser 405 410 415 Pro His Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu 420 425 430 Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro 435 440 445 Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly Ser 450 455 460 Gln Gly Arg Ser Pro Ser Tyr Ala Ser 465 470 <210> 117 <211> 473 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 117 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Gln Leu Leu Glu Lys 1 5 10 15 Arg Ala Ala His Leu Phe Ile Glu Trp Leu Ile Lys Gly Gly His Ser 20 25 30 Ser Ile Lys Pro Pro Pro Lys Gly Gly Gly Gly Gly Gly Gly Ser Gly 35 40 45 Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Glu Ser Lys Tyr Gly Pro 50 55 60 Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val 65 70 75 80 Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 85 90 95 Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 100 105 110 Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 115 120 125 Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 130 135 140 Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 145 150 155 160 Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 165 170 175 Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 180 185 190 Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 195 200 205 Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 210 215 220 Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 225 230 235 240 Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 245 250 255 Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 260 265 270 His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Gly Gly 275 280 285 Gly Ser Gly Ser Ala His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln 290 295 300 Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Cys 305 310 315 320 Gln Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly 325 330 335 Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys 340 345 350 Pro Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys 355 360 365 Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu 370 375 380 Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr 385 390 395 400 Gln Ser Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Cys Lys Ser 405 410 415 Pro His Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu 420 425 430 Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro 435 440 445 Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly Ser 450 455 460 Gln Gly Arg Ser Pro Ser Tyr Ala Ser 465 470 <210> 118 <211> 473 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 118 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Gln Leu Leu Glu Lys 1 5 10 15 Arg Leu Ala His Leu Phe Ile Glu Trp Leu Ile Ala Gly Gly His Ser 20 25 30 Lys Ile Lys Tyr Pro Pro Lys Gly Gly Gly Gly Gly Gly Gly Ser Gly 35 40 45 Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Glu Ser Lys Tyr Gly Pro 50 55 60 Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val 65 70 75 80 Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 85 90 95 Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 100 105 110 Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 115 120 125 Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 130 135 140 Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 145 150 155 160 Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 165 170 175 Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 180 185 190 Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 195 200 205 Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 210 215 220 Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 225 230 235 240 Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 245 250 255 Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 260 265 270 His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Gly Gly 275 280 285 Gly Ser Gly Ser Ala His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln 290 295 300 Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Cys 305 310 315 320 Gln Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly 325 330 335 Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys 340 345 350 Pro Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys 355 360 365 Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu 370 375 380 Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr 385 390 395 400 Gln Ser Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Cys Lys Ser 405 410 415 Pro His Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu 420 425 430 Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro 435 440 445 Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly Ser 450 455 460 Gln Gly Arg Ser Pro Ser Tyr Ala Ser 465 470 <210> 119 <211> 473 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 119 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Gln Leu Leu Glu Lys 1 5 10 15 Glu Leu Ala His Leu Phe Ile Glu Trp Leu Ile Ala Gly Gly His Ser 20 25 30 Ser Ile Lys Pro Pro Pro Lys Gly Gly Gly Gly Gly Gly Gly Ser Gly 35 40 45 Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Glu Ser Lys Tyr Gly Pro 50 55 60 Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val 65 70 75 80 Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 85 90 95 Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 100 105 110 Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 115 120 125 Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 130 135 140 Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 145 150 155 160 Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 165 170 175 Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 180 185 190 Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 195 200 205 Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 210 215 220 Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 225 230 235 240 Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 245 250 255 Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 260 265 270 His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Gly Gly 275 280 285 Gly Ser Gly Ser Ala His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln 290 295 300 Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Cys 305 310 315 320 Gln Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly 325 330 335 Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys 340 345 350 Pro Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys 355 360 365 Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu 370 375 380 Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr 385 390 395 400 Gln Ser Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Cys Lys Ser 405 410 415 Pro His Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu 420 425 430 Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro 435 440 445 Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly Ser 450 455 460 Gln Gly Arg Ser Pro Ser Tyr Ala Ser 465 470 <210> 120 <211> 473 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 120 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Gln Leu Leu Glu Lys 1 5 10 15 Arg Leu Ala His Leu Phe Ile Glu Trp Leu Ile Ala Gly Gly His Lys 20 25 30 Lys Gly Lys Tyr Pro Pro Lys Gly Gly Gly Gly Gly Gly Gly Ser Gly 35 40 45 Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Glu Ser Lys Tyr Gly Pro 50 55 60 Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val 65 70 75 80 Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 85 90 95 Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 100 105 110 Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 115 120 125 Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 130 135 140 Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 145 150 155 160 Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 165 170 175 Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 180 185 190 Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 195 200 205 Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 210 215 220 Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 225 230 235 240 Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 245 250 255 Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 260 265 270 His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Gly Gly 275 280 285 Gly Ser Gly Ser Ala His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln 290 295 300 Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Cys 305 310 315 320 Gln Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly 325 330 335 Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys 340 345 350 Pro Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys 355 360 365 Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu 370 375 380 Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr 385 390 395 400 Gln Ser Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Cys Lys Ser 405 410 415 Pro His Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu 420 425 430 Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro 435 440 445 Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly Ser 450 455 460 Gln Gly Arg Ser Pro Ser Tyr Ala Ser 465 470 <210> 121 <211> 473 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 121 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Gln Leu Leu Glu Lys 1 5 10 15 Arg Leu Ala His Leu Phe Ile Glu Trp Leu Ile Ala Gly Gly Pro Ser 20 25 30 Ser Gly Arg Tyr Pro Pro Lys Gly Gly Gly Gly Gly Gly Gly Ser Gly 35 40 45 Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Glu Ser Lys Tyr Gly Pro 50 55 60 Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val 65 70 75 80 Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 85 90 95 Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 100 105 110 Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 115 120 125 Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 130 135 140 Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 145 150 155 160 Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 165 170 175 Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 180 185 190 Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 195 200 205 Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 210 215 220 Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 225 230 235 240 Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 245 250 255 Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 260 265 270 His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Gly Gly 275 280 285 Gly Ser Gly Ser Ala His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln 290 295 300 Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Cys 305 310 315 320 Gln Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly 325 330 335 Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys 340 345 350 Pro Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys 355 360 365 Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu 370 375 380 Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr 385 390 395 400 Gln Ser Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Cys Lys Ser 405 410 415 Pro His Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu 420 425 430 Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro 435 440 445 Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly Ser 450 455 460 Gln Gly Arg Ser Pro Ser Tyr Ala Ser 465 470 <210> 122 <211> 473 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 122 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Gln Leu Leu Glu Lys 1 5 10 15 Arg Leu Ala His Leu Phe Ile Glu Trp Leu Ile Ala Gly Gly His Ser 20 25 30 Ser Ile Lys Pro Pro Pro Lys Gly Gly Gly Gly Gly Gly Gly Ser Gly 35 40 45 Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Glu Ser Lys Tyr Gly Pro 50 55 60 Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val 65 70 75 80 Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 85 90 95 Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 100 105 110 Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 115 120 125 Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 130 135 140 Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 145 150 155 160 Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 165 170 175 Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 180 185 190 Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 195 200 205 Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 210 215 220 Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 225 230 235 240 Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 245 250 255 Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 260 265 270 His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Gly Gly 275 280 285 Gly Ser Gly Ser Ala His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln 290 295 300 Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Cys 305 310 315 320 Gln Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly 325 330 335 Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys 340 345 350 Pro Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys 355 360 365 Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu 370 375 380 Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr 385 390 395 400 Gln Ser Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Cys Lys Ser 405 410 415 Pro His Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu 420 425 430 Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro 435 440 445 Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly Ser 450 455 460 Gln Gly Arg Ser Pro Ser Tyr Ala Ser 465 470 <210> 123 <211> 473 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 123 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Lys Leu Leu Glu Lys 1 5 10 15 Arg Leu Ala His Leu Phe Ile Glu Trp Leu Ile Lys Gly Gly His Ser 20 25 30 Ser Ile Lys Pro Pro Pro Lys Gly Gly Gly Gly Gly Gly Gly Ser Gly 35 40 45 Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Glu Ser Lys Tyr Gly Pro 50 55 60 Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val 65 70 75 80 Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 85 90 95 Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 100 105 110 Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 115 120 125 Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 130 135 140 Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 145 150 155 160 Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 165 170 175 Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 180 185 190 Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 195 200 205 Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 210 215 220 Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 225 230 235 240 Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 245 250 255 Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 260 265 270 His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Gly Gly 275 280 285 Gly Ser Gly Ser Ala His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln 290 295 300 Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Cys 305 310 315 320 Gln Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly 325 330 335 Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys 340 345 350 Pro Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys 355 360 365 Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu 370 375 380 Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr 385 390 395 400 Gln Ser Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Cys Lys Ser 405 410 415 Pro His Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu 420 425 430 Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro 435 440 445 Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly Ser 450 455 460 Gln Gly Arg Ser Pro Ser Tyr Ala Ser 465 470 <210> 124 <211> 473 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 124 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Lys Leu Leu Glu Lys 1 5 10 15 Arg Leu Ala His Leu Phe Ile Glu Trp Leu Ile Ala Gly Gly His Ser 20 25 30 Lys Gly Lys Pro Pro Pro Lys Gly Gly Gly Gly Gly Gly Gly Ser Gly 35 40 45 Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Glu Ser Lys Tyr Gly Pro 50 55 60 Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val 65 70 75 80 Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 85 90 95 Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 100 105 110 Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 115 120 125 Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 130 135 140 Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 145 150 155 160 Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 165 170 175 Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 180 185 190 Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 195 200 205 Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 210 215 220 Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 225 230 235 240 Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 245 250 255 Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 260 265 270 His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Gly Gly 275 280 285 Gly Ser Gly Ser Ala His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln 290 295 300 Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Cys 305 310 315 320 Gln Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly 325 330 335 Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys 340 345 350 Pro Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys 355 360 365 Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu 370 375 380 Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr 385 390 395 400 Gln Ser Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Cys Lys Ser 405 410 415 Pro His Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu 420 425 430 Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro 435 440 445 Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly Ser 450 455 460 Gln Gly Arg Ser Pro Ser Tyr Ala Ser 465 470 <210> 125 <211> 473 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 125 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Gln Leu Leu Glu Lys 1 5 10 15 Glu Ala Ala His Leu Phe Ile Glu Trp Leu Ile Ala Gly Gly His Ser 20 25 30 Lys Gly Lys Pro Pro Pro Lys Gly Gly Gly Gly Gly Gly Gly Ser Gly 35 40 45 Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Glu Ser Lys Tyr Gly Pro 50 55 60 Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val 65 70 75 80 Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 85 90 95 Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 100 105 110 Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 115 120 125 Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 130 135 140 Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 145 150 155 160 Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 165 170 175 Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 180 185 190 Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 195 200 205 Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 210 215 220 Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 225 230 235 240 Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 245 250 255 Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 260 265 270 His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Gly Gly 275 280 285 Gly Ser Gly Ser Ala His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln 290 295 300 Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Cys 305 310 315 320 Gln Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly 325 330 335 Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys 340 345 350 Pro Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys 355 360 365 Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu 370 375 380 Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr 385 390 395 400 Gln Ser Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Cys Lys Ser 405 410 415 Pro His Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu 420 425 430 Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro 435 440 445 Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly Ser 450 455 460 Gln Gly Arg Ser Pro Ser Tyr Ala Ser 465 470 <210> 126 <211> 473 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 126 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Lys Leu Leu Glu Lys 1 5 10 15 Arg Ala Ala His Leu Phe Ile Glu Trp Leu Ile Ala Gly Gly His Ser 20 25 30 Ser Ile Lys Pro Pro Pro Lys Gly Gly Gly Gly Gly Gly Gly Ser Gly 35 40 45 Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Glu Ser Lys Tyr Gly Pro 50 55 60 Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val 65 70 75 80 Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 85 90 95 Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 100 105 110 Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 115 120 125 Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 130 135 140 Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 145 150 155 160 Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 165 170 175 Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 180 185 190 Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 195 200 205 Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 210 215 220 Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 225 230 235 240 Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 245 250 255 Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 260 265 270 His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Gly Gly 275 280 285 Gly Ser Gly Ser Ala His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln 290 295 300 Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Cys 305 310 315 320 Gln Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly 325 330 335 Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys 340 345 350 Pro Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys 355 360 365 Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu 370 375 380 Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr 385 390 395 400 Gln Ser Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Cys Lys Ser 405 410 415 Pro His Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu 420 425 430 Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro 435 440 445 Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly Ser 450 455 460 Gln Gly Arg Ser Pro Ser Tyr Ala Ser 465 470 <210> 127 <211> 473 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 127 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Gln Leu Leu Glu Lys 1 5 10 15 Arg Leu Ala His Leu Phe Ile Glu Trp Leu Ile Lys Gly Gly His Ser 20 25 30 Ser Gly Arg Pro Pro Pro Lys Gly Gly Gly Gly Gly Gly Gly Ser Gly 35 40 45 Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Glu Ser Lys Tyr Gly Pro 50 55 60 Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val 65 70 75 80 Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 85 90 95 Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 100 105 110 Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 115 120 125 Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 130 135 140 Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 145 150 155 160 Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 165 170 175 Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 180 185 190 Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 195 200 205 Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 210 215 220 Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 225 230 235 240 Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 245 250 255 Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 260 265 270 His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Gly Gly 275 280 285 Gly Ser Gly Ser Ala His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln 290 295 300 Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Cys 305 310 315 320 Gln Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly 325 330 335 Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys 340 345 350 Pro Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys 355 360 365 Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu 370 375 380 Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr 385 390 395 400 Gln Ser Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Cys Lys Ser 405 410 415 Pro His Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu 420 425 430 Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro 435 440 445 Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly Ser 450 455 460 Gln Gly Arg Ser Pro Ser Tyr Ala Ser 465 470 <210> 128 <211> 473 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 128 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Gln Leu Leu Glu Lys 1 5 10 15 Arg Leu Ala His Leu Phe Ile Glu Trp Leu Ile Lys Gly Gly His Ser 20 25 30 Lys Gly Lys Tyr Pro Pro Lys Gly Gly Gly Gly Gly Gly Gly Ser Gly 35 40 45 Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Glu Ser Lys Tyr Gly Pro 50 55 60 Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val 65 70 75 80 Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 85 90 95 Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 100 105 110 Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 115 120 125 Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 130 135 140 Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 145 150 155 160 Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 165 170 175 Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 180 185 190 Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 195 200 205 Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 210 215 220 Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 225 230 235 240 Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 245 250 255 Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 260 265 270 His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Gly Gly 275 280 285 Gly Ser Gly Ser Ala His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln 290 295 300 Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Cys 305 310 315 320 Gln Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly 325 330 335 Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys 340 345 350 Pro Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys 355 360 365 Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu 370 375 380 Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr 385 390 395 400 Gln Ser Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Cys Lys Ser 405 410 415 Pro His Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu 420 425 430 Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro 435 440 445 Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly Ser 450 455 460 Gln Gly Arg Ser Pro Ser Tyr Ala Ser 465 470 <210> 129 <211> 473 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 129 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Gln Leu Leu Glu Glu 1 5 10 15 Arg Leu Ala His Leu Phe Ile Glu Trp Leu Ile Ala Gly Gly His Ser 20 25 30 Lys Gln Lys Pro Pro Pro Lys Gly Gly Gly Gly Gly Gly Gly Ser Gly 35 40 45 Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Glu Ser Lys Tyr Gly Pro 50 55 60 Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val 65 70 75 80 Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 85 90 95 Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 100 105 110 Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 115 120 125 Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 130 135 140 Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 145 150 155 160 Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 165 170 175 Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 180 185 190 Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 195 200 205 Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 210 215 220 Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 225 230 235 240 Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 245 250 255 Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 260 265 270 His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Gly Gly 275 280 285 Gly Ser Gly Ser Ala His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln 290 295 300 Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Cys 305 310 315 320 Gln Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly 325 330 335 Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys 340 345 350 Pro Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys 355 360 365 Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu 370 375 380 Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr 385 390 395 400 Gln Ser Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Cys Lys Ser 405 410 415 Pro His Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu 420 425 430 Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro 435 440 445 Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly Ser 450 455 460 Gln Gly Arg Ser Pro Ser Tyr Ala Ser 465 470 <210> 130 <211> 473 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 130 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Gln Leu Leu Glu Lys 1 5 10 15 Glu Leu Ala His Leu Phe Ile Glu Trp Leu Leu Ala Gly Gly His Ser 20 25 30 Lys Gly Lys Pro Pro Pro Lys Gly Gly Gly Gly Gly Gly Gly Ser Gly 35 40 45 Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Glu Ser Lys Tyr Gly Pro 50 55 60 Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val 65 70 75 80 Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 85 90 95 Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 100 105 110 Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 115 120 125 Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 130 135 140 Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 145 150 155 160 Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 165 170 175 Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 180 185 190 Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 195 200 205 Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 210 215 220 Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 225 230 235 240 Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 245 250 255 Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 260 265 270 His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Gly Gly 275 280 285 Gly Ser Gly Ser Ala His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln 290 295 300 Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Cys 305 310 315 320 Gln Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly 325 330 335 Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys 340 345 350 Pro Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys 355 360 365 Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu 370 375 380 Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr 385 390 395 400 Gln Ser Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Cys Lys Ser 405 410 415 Pro His Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu 420 425 430 Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro 435 440 445 Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly Ser 450 455 460 Gln Gly Arg Ser Pro Ser Tyr Ala Ser 465 470 <210> 131 <211> 473 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 131 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Gln Leu Leu Glu Lys 1 5 10 15 Glu Leu Ala His Leu Phe Ile Glu Trp Leu Ile Ala Gly Gly His Ser 20 25 30 Lys Gln Lys Pro Pro Pro Lys Gly Gly Gly Gly Gly Gly Gly Ser Gly 35 40 45 Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Glu Ser Lys Tyr Gly Pro 50 55 60 Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val 65 70 75 80 Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 85 90 95 Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 100 105 110 Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 115 120 125 Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 130 135 140 Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 145 150 155 160 Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 165 170 175 Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 180 185 190 Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 195 200 205 Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 210 215 220 Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 225 230 235 240 Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 245 250 255 Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 260 265 270 His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Gly Gly 275 280 285 Gly Ser Gly Ser Ala His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln 290 295 300 Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Cys 305 310 315 320 Gln Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly 325 330 335 Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys 340 345 350 Pro Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys 355 360 365 Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu 370 375 380 Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr 385 390 395 400 Gln Ser Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Cys Lys Ser 405 410 415 Pro His Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu 420 425 430 Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro 435 440 445 Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly Ser 450 455 460 Gln Gly Arg Ser Pro Ser Tyr Ala Ser 465 470 <210> 132 <211> 473 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 132 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Gln Leu Leu Glu Lys 1 5 10 15 Arg Leu Ala His Leu Phe Ile Glu Trp Leu Leu Ala Gly Gly His Ser 20 25 30 Ser Gly Lys Leu Ser Pro Lys Gly Gly Gly Gly Gly Gly Gly Ser Gly 35 40 45 Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Glu Ser Lys Tyr Gly Pro 50 55 60 Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val 65 70 75 80 Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 85 90 95 Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 100 105 110 Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 115 120 125 Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 130 135 140 Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 145 150 155 160 Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 165 170 175 Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 180 185 190 Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 195 200 205 Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 210 215 220 Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 225 230 235 240 Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 245 250 255 Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 260 265 270 His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Gly Gly 275 280 285 Gly Ser Gly Ser Ala His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln 290 295 300 Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Cys 305 310 315 320 Gln Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly 325 330 335 Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys 340 345 350 Pro Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys 355 360 365 Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu 370 375 380 Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr 385 390 395 400 Gln Ser Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Cys Lys Ser 405 410 415 Pro His Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu 420 425 430 Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro 435 440 445 Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly Ser 450 455 460 Gln Gly Arg Ser Pro Ser Tyr Ala Ser 465 470 <210> 133 <211> 473 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 133 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Gln Leu Leu Glu Lys 1 5 10 15 Arg Leu Ala His Leu Phe Ile Glu Trp Leu Ile Lys Gly Gly His Ser 20 25 30 Lys Gln Lys Pro Pro Pro Lys Gly Gly Gly Gly Gly Gly Gly Ser Gly 35 40 45 Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Glu Ser Lys Tyr Gly Pro 50 55 60 Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val 65 70 75 80 Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 85 90 95 Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 100 105 110 Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 115 120 125 Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 130 135 140 Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 145 150 155 160 Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 165 170 175 Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 180 185 190 Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 195 200 205 Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 210 215 220 Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 225 230 235 240 Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 245 250 255 Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 260 265 270 His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Gly Gly 275 280 285 Gly Ser Gly Ser Ala His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln 290 295 300 Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Cys 305 310 315 320 Gln Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly 325 330 335 Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys 340 345 350 Pro Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys 355 360 365 Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu 370 375 380 Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr 385 390 395 400 Gln Ser Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Cys Lys Ser 405 410 415 Pro His Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu 420 425 430 Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro 435 440 445 Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly Ser 450 455 460 Gln Gly Arg Ser Pro Ser Tyr Ala Ser 465 470 <210> 134 <211> 473 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 134 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Lys Leu Leu Glu Lys 1 5 10 15 Arg Leu Ala His Leu Phe Ile Glu Trp Leu Ile Lys Gly Gly His Lys 20 25 30 Ser Gly Lys Pro Pro Pro Lys Gly Gly Gly Gly Gly Gly Gly Ser Gly 35 40 45 Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Glu Ser Lys Tyr Gly Pro 50 55 60 Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val 65 70 75 80 Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 85 90 95 Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 100 105 110 Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 115 120 125 Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 130 135 140 Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 145 150 155 160 Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 165 170 175 Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 180 185 190 Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 195 200 205 Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 210 215 220 Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 225 230 235 240 Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 245 250 255 Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 260 265 270 His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Gly Gly 275 280 285 Gly Ser Gly Ser Ala His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln 290 295 300 Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Cys 305 310 315 320 Gln Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly 325 330 335 Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys 340 345 350 Pro Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys 355 360 365 Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu 370 375 380 Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr 385 390 395 400 Gln Ser Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Cys Lys Ser 405 410 415 Pro His Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu 420 425 430 Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro 435 440 445 Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly Ser 450 455 460 Gln Gly Arg Ser Pro Ser Tyr Ala Ser 465 470 <210> 135 <211> 473 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 135 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Gln Leu Leu Glu Glu 1 5 10 15 Arg Leu Val His Leu Phe Ile Glu Trp Leu Ile Ala Gly Gly His Ser 20 25 30 Ser Gly Lys Leu Pro Pro Lys Gly Gly Gly Gly Gly Gly Gly Ser Gly 35 40 45 Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Glu Ser Lys Tyr Gly Pro 50 55 60 Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val 65 70 75 80 Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 85 90 95 Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 100 105 110 Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 115 120 125 Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 130 135 140 Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 145 150 155 160 Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 165 170 175 Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 180 185 190 Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 195 200 205 Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 210 215 220 Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 225 230 235 240 Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 245 250 255 Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 260 265 270 His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Gly Gly 275 280 285 Gly Ser Gly Ser Ala His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln 290 295 300 Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Cys 305 310 315 320 Gln Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly 325 330 335 Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys 340 345 350 Pro Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys 355 360 365 Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu 370 375 380 Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr 385 390 395 400 Gln Ser Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Cys Lys Ser 405 410 415 Pro His Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu 420 425 430 Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro 435 440 445 Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly Ser 450 455 460 Gln Gly Arg Ser Pro Ser Tyr Ala Ser 465 470 <210> 136 <211> 473 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 136 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Lys Leu Leu Glu Lys 1 5 10 15 Arg Leu Ala His Leu Phe Ile Glu Trp Leu Leu Ala Gly Gly His Ser 20 25 30 Lys Gly Lys Pro Pro Pro Lys Gly Gly Gly Gly Gly Gly Gly Ser Gly 35 40 45 Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Glu Ser Lys Tyr Gly Pro 50 55 60 Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val 65 70 75 80 Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 85 90 95 Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 100 105 110 Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 115 120 125 Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 130 135 140 Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 145 150 155 160 Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 165 170 175 Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 180 185 190 Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 195 200 205 Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 210 215 220 Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 225 230 235 240 Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 245 250 255 Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 260 265 270 His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Gly Gly 275 280 285 Gly Ser Gly Ser Ala His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln 290 295 300 Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Cys 305 310 315 320 Gln Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly 325 330 335 Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys 340 345 350 Pro Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys 355 360 365 Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu 370 375 380 Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr 385 390 395 400 Gln Ser Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Cys Lys Ser 405 410 415 Pro His Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu 420 425 430 Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro 435 440 445 Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly Ser 450 455 460 Gln Gly Arg Ser Pro Ser Tyr Ala Ser 465 470 <210> 137 <211> 473 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 137 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Gln Leu Leu Glu Lys 1 5 10 15 Arg Ala Ala His Leu Phe Ile Glu Trp Leu Leu Ala Gly Gly His Ser 20 25 30 Ser Ile Lys Pro Pro Pro Lys Gly Gly Gly Gly Gly Gly Gly Ser Gly 35 40 45 Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Glu Ser Lys Tyr Gly Pro 50 55 60 Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val 65 70 75 80 Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 85 90 95 Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 100 105 110 Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 115 120 125 Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 130 135 140 Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 145 150 155 160 Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 165 170 175 Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 180 185 190 Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 195 200 205 Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 210 215 220 Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 225 230 235 240 Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 245 250 255 Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 260 265 270 His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Gly Gly 275 280 285 Gly Ser Gly Ser Ala His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln 290 295 300 Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Cys 305 310 315 320 Gln Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly 325 330 335 Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys 340 345 350 Pro Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys 355 360 365 Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu 370 375 380 Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr 385 390 395 400 Gln Ser Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Cys Lys Ser 405 410 415 Pro His Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu 420 425 430 Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro 435 440 445 Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly Ser 450 455 460 Gln Gly Arg Ser Pro Ser Tyr Ala Ser 465 470 <210> 138 <211> 473 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 138 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Gln Leu Leu Glu Lys 1 5 10 15 Glu Leu Ala His Leu Phe Ile Glu Trp Leu Ile Ala Gly Gly His Ser 20 25 30 Ser Ile Arg Pro Pro Pro Lys Gly Gly Gly Gly Gly Gly Gly Ser Gly 35 40 45 Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Glu Ser Lys Tyr Gly Pro 50 55 60 Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val 65 70 75 80 Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 85 90 95 Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 100 105 110 Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 115 120 125 Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 130 135 140 Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 145 150 155 160 Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 165 170 175 Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 180 185 190 Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 195 200 205 Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 210 215 220 Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 225 230 235 240 Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 245 250 255 Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 260 265 270 His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Gly Gly 275 280 285 Gly Ser Gly Ser Ala His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln 290 295 300 Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Cys 305 310 315 320 Gln Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly 325 330 335 Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys 340 345 350 Pro Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys 355 360 365 Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu 370 375 380 Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr 385 390 395 400 Gln Ser Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Cys Lys Ser 405 410 415 Pro His Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu 420 425 430 Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro 435 440 445 Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly Ser 450 455 460 Gln Gly Arg Ser Pro Ser Tyr Ala Ser 465 470 <210> 139 <211> 473 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 139 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Gln Leu Leu Glu Lys 1 5 10 15 Arg Ala Ala His Leu Phe Ile Glu Trp Leu Ile Ala Gly Gly His Ser 20 25 30 Ser Gly Lys Leu Ser Pro Lys Gly Gly Gly Gly Gly Gly Gly Ser Gly 35 40 45 Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Glu Ser Lys Tyr Gly Pro 50 55 60 Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val 65 70 75 80 Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 85 90 95 Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 100 105 110 Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 115 120 125 Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 130 135 140 Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 145 150 155 160 Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 165 170 175 Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 180 185 190 Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 195 200 205 Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 210 215 220 Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 225 230 235 240 Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 245 250 255 Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 260 265 270 His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Gly Gly 275 280 285 Gly Ser Gly Ser Ala His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln 290 295 300 Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Cys 305 310 315 320 Gln Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly 325 330 335 Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys 340 345 350 Pro Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys 355 360 365 Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu 370 375 380 Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr 385 390 395 400 Gln Ser Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Cys Lys Ser 405 410 415 Pro His Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu 420 425 430 Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro 435 440 445 Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly Ser 450 455 460 Gln Gly Arg Ser Pro Ser Tyr Ala Ser 465 470 <210> 140 <211> 473 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 140 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Gln Leu Leu Glu Lys 1 5 10 15 Arg Leu Ala His Leu Phe Ile Glu Trp Leu Ile Lys Gly Gly His Ser 20 25 30 Lys Gly Lys Pro Pro Pro Lys Gly Gly Gly Gly Gly Gly Gly Ser Gly 35 40 45 Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Glu Ser Lys Tyr Gly Pro 50 55 60 Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val 65 70 75 80 Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 85 90 95 Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 100 105 110 Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 115 120 125 Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 130 135 140 Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 145 150 155 160 Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 165 170 175 Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 180 185 190 Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 195 200 205 Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 210 215 220 Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 225 230 235 240 Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 245 250 255 Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 260 265 270 His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Gly Gly 275 280 285 Gly Ser Gly Ser Ala His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln 290 295 300 Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Cys 305 310 315 320 Gln Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly 325 330 335 Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys 340 345 350 Pro Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys 355 360 365 Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu 370 375 380 Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr 385 390 395 400 Gln Ser Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Cys Lys Ser 405 410 415 Pro His Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu 420 425 430 Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro 435 440 445 Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly Ser 450 455 460 Gln Gly Arg Ser Pro Ser Tyr Ala Ser 465 470 <210> 141 <211> 473 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 141 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Lys Leu Leu Glu Lys 1 5 10 15 Arg Ala Ala His Leu Phe Ile Glu Trp Leu Ile Ala Gly Gly His Ser 20 25 30 Lys Gly Lys Pro Pro Pro Lys Gly Gly Gly Gly Gly Gly Gly Ser Gly 35 40 45 Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Glu Ser Lys Tyr Gly Pro 50 55 60 Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val 65 70 75 80 Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 85 90 95 Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 100 105 110 Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 115 120 125 Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 130 135 140 Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 145 150 155 160 Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 165 170 175 Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 180 185 190 Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 195 200 205 Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 210 215 220 Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 225 230 235 240 Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 245 250 255 Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 260 265 270 His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Gly Gly 275 280 285 Gly Ser Gly Ser Ala His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln 290 295 300 Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Cys 305 310 315 320 Gln Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly 325 330 335 Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys 340 345 350 Pro Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys 355 360 365 Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu 370 375 380 Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr 385 390 395 400 Gln Ser Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Cys Lys Ser 405 410 415 Pro His Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu 420 425 430 Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro 435 440 445 Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly Ser 450 455 460 Gln Gly Arg Ser Pro Ser Tyr Ala Ser 465 470 <210> 142 <211> 473 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 142 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Gln Leu Leu Glu Lys 1 5 10 15 Arg Leu Ala His Leu Phe Ile Glu Trp Leu Ile Ala Gly Gly His Lys 20 25 30 Ser Gly Lys Tyr Ser Pro Lys Gly Gly Gly Gly Gly Gly Gly Ser Gly 35 40 45 Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Glu Ser Lys Tyr Gly Pro 50 55 60 Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val 65 70 75 80 Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 85 90 95 Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 100 105 110 Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 115 120 125 Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 130 135 140 Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 145 150 155 160 Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 165 170 175 Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 180 185 190 Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 195 200 205 Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 210 215 220 Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 225 230 235 240 Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 245 250 255 Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 260 265 270 His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Gly Gly 275 280 285 Gly Ser Gly Ser Ala His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln 290 295 300 Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Cys 305 310 315 320 Gln Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly 325 330 335 Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys 340 345 350 Pro Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys 355 360 365 Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu 370 375 380 Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr 385 390 395 400 Gln Ser Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Cys Lys Ser 405 410 415 Pro His Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu 420 425 430 Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro 435 440 445 Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly Ser 450 455 460 Gln Gly Arg Ser Pro Ser Tyr Ala Ser 465 470 <210> 143 <211> 473 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 143 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Gln Leu Leu Glu Lys 1 5 10 15 Arg Leu Ala His Leu Phe Ile Glu Trp Leu Leu Lys Gly Gly His Ser 20 25 30 Lys Gly Lys Pro Pro Pro Lys Gly Gly Gly Gly Gly Gly Gly Ser Gly 35 40 45 Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Glu Ser Lys Tyr Gly Pro 50 55 60 Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val 65 70 75 80 Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 85 90 95 Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 100 105 110 Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 115 120 125 Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 130 135 140 Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 145 150 155 160 Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 165 170 175 Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 180 185 190 Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 195 200 205 Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 210 215 220 Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 225 230 235 240 Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 245 250 255 Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 260 265 270 His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Gly Gly 275 280 285 Gly Ser Gly Ser Ala His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln 290 295 300 Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Cys 305 310 315 320 Gln Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly 325 330 335 Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys 340 345 350 Pro Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys 355 360 365 Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu 370 375 380 Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr 385 390 395 400 Gln Ser Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Cys Lys Ser 405 410 415 Pro His Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu 420 425 430 Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro 435 440 445 Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly Ser 450 455 460 Gln Gly Arg Ser Pro Ser Tyr Ala Ser 465 470 <210> 144 <211> 473 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 144 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Gln Leu Leu Glu Lys 1 5 10 15 Arg Leu Ala His Leu Phe Ile Glu Trp Leu Ile Lys Gly Gly Pro Ser 20 25 30 Ser Ile Lys Pro Pro Pro Lys Gly Gly Gly Gly Gly Gly Gly Ser Gly 35 40 45 Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Glu Ser Lys Tyr Gly Pro 50 55 60 Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val 65 70 75 80 Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 85 90 95 Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 100 105 110 Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 115 120 125 Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 130 135 140 Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 145 150 155 160 Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 165 170 175 Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 180 185 190 Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 195 200 205 Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 210 215 220 Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 225 230 235 240 Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 245 250 255 Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 260 265 270 His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Gly Gly 275 280 285 Gly Ser Gly Ser Ala His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln 290 295 300 Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Cys 305 310 315 320 Gln Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly 325 330 335 Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys 340 345 350 Pro Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys 355 360 365 Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu 370 375 380 Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr 385 390 395 400 Gln Ser Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Cys Lys Ser 405 410 415 Pro His Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu 420 425 430 Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro 435 440 445 Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly Ser 450 455 460 Gln Gly Arg Ser Pro Ser Tyr Ala Ser 465 470 <210> 145 <211> 473 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 145 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Gln Leu Leu Glu Lys 1 5 10 15 Arg Leu Ala His Leu Phe Ile Glu Trp Leu Ile Lys Gly Gly His Ser 20 25 30 Ser Ile Arg Pro Pro Pro Lys Gly Gly Gly Gly Gly Gly Gly Ser Gly 35 40 45 Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Glu Ser Lys Tyr Gly Pro 50 55 60 Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val 65 70 75 80 Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 85 90 95 Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 100 105 110 Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 115 120 125 Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 130 135 140 Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 145 150 155 160 Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 165 170 175 Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 180 185 190 Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 195 200 205 Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 210 215 220 Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 225 230 235 240 Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 245 250 255 Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 260 265 270 His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Gly Gly 275 280 285 Gly Ser Gly Ser Ala His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln 290 295 300 Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Cys 305 310 315 320 Gln Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly 325 330 335 Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys 340 345 350 Pro Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys 355 360 365 Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu 370 375 380 Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr 385 390 395 400 Gln Ser Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Cys Lys Ser 405 410 415 Pro His Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu 420 425 430 Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro 435 440 445 Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly Ser 450 455 460 Gln Gly Arg Ser Pro Ser Tyr Ala Ser 465 470 <210> 146 <211> 473 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 146 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Gln Leu Leu Glu Lys 1 5 10 15 Arg Leu Ala His Leu Phe Ile Glu Trp Leu Leu Ala Gly Gly His Lys 20 25 30 Lys Gly Lys Pro Pro Pro Lys Gly Gly Gly Gly Gly Gly Gly Ser Gly 35 40 45 Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Glu Ser Lys Tyr Gly Pro 50 55 60 Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val 65 70 75 80 Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 85 90 95 Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 100 105 110 Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 115 120 125 Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 130 135 140 Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 145 150 155 160 Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 165 170 175 Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 180 185 190 Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 195 200 205 Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 210 215 220 Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 225 230 235 240 Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 245 250 255 Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 260 265 270 His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Gly Gly 275 280 285 Gly Ser Gly Ser Ala His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln 290 295 300 Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Cys 305 310 315 320 Gln Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly 325 330 335 Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys 340 345 350 Pro Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys 355 360 365 Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu 370 375 380 Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr 385 390 395 400 Gln Ser Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Cys Lys Ser 405 410 415 Pro His Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu 420 425 430 Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro 435 440 445 Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly Ser 450 455 460 Gln Gly Arg Ser Pro Ser Tyr Ala Ser 465 470 <210> 147 <211> 473 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 147 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Gln Leu Leu Glu Lys 1 5 10 15 Arg Leu Ala His Leu Phe Ile Glu Trp Leu Leu Lys Gly Gly His Ser 20 25 30 Ser Gly Arg Pro Pro Pro Lys Gly Gly Gly Gly Gly Gly Gly Ser Gly 35 40 45 Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Glu Ser Lys Tyr Gly Pro 50 55 60 Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val 65 70 75 80 Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 85 90 95 Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 100 105 110 Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 115 120 125 Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 130 135 140 Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 145 150 155 160 Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 165 170 175 Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 180 185 190 Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 195 200 205 Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 210 215 220 Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 225 230 235 240 Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 245 250 255 Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 260 265 270 His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Gly Gly 275 280 285 Gly Ser Gly Ser Ala His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln 290 295 300 Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Cys 305 310 315 320 Gln Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly 325 330 335 Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys 340 345 350 Pro Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys 355 360 365 Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu 370 375 380 Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr 385 390 395 400 Gln Ser Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Cys Lys Ser 405 410 415 Pro His Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu 420 425 430 Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro 435 440 445 Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly Ser 450 455 460 Gln Gly Arg Ser Pro Ser Tyr Ala Ser 465 470 <210> 148 <211> 473 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 148 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Gln Leu Leu Glu Lys 1 5 10 15 Arg Leu Ala His Leu Phe Ile Glu Trp Leu Ile Ala Gly Gly Pro Ser 20 25 30 Ser Gly Lys Tyr Ser Pro Lys Gly Gly Gly Gly Gly Gly Gly Ser Gly 35 40 45 Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Glu Ser Lys Tyr Gly Pro 50 55 60 Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val 65 70 75 80 Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 85 90 95 Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 100 105 110 Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 115 120 125 Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 130 135 140 Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 145 150 155 160 Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 165 170 175 Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 180 185 190 Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 195 200 205 Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 210 215 220 Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 225 230 235 240 Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 245 250 255 Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 260 265 270 His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Gly Gly 275 280 285 Gly Ser Gly Ser Ala His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln 290 295 300 Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Cys 305 310 315 320 Gln Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly 325 330 335 Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys 340 345 350 Pro Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys 355 360 365 Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu 370 375 380 Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr 385 390 395 400 Gln Ser Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Cys Lys Ser 405 410 415 Pro His Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu 420 425 430 Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro 435 440 445 Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly Ser 450 455 460 Gln Gly Arg Ser Pro Ser Tyr Ala Ser 465 470 <210> 149 <211> 473 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 149 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Gln Leu Leu Glu Lys 1 5 10 15 Arg Ala Ala His Leu Phe Ile Glu Trp Leu Ile Ala Gly Gly Pro Ser 20 25 30 Ser Gly Lys Leu Pro Pro Lys Gly Gly Gly Gly Gly Gly Gly Ser Gly 35 40 45 Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Glu Ser Lys Tyr Gly Pro 50 55 60 Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val 65 70 75 80 Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 85 90 95 Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 100 105 110 Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 115 120 125 Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 130 135 140 Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 145 150 155 160 Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 165 170 175 Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 180 185 190 Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 195 200 205 Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 210 215 220 Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 225 230 235 240 Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 245 250 255 Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 260 265 270 His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Gly Gly 275 280 285 Gly Ser Gly Ser Ala His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln 290 295 300 Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Cys 305 310 315 320 Gln Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly 325 330 335 Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys 340 345 350 Pro Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys 355 360 365 Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu 370 375 380 Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr 385 390 395 400 Gln Ser Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Cys Lys Ser 405 410 415 Pro His Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu 420 425 430 Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro 435 440 445 Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly Ser 450 455 460 Gln Gly Arg Ser Pro Ser Tyr Ala Ser 465 470 <210> 150 <211> 473 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 150 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Gln Leu Leu Glu Lys 1 5 10 15 Glu Leu Ala His Leu Phe Ile Glu Trp Leu Ile Ala Gly Gly His Ser 20 25 30 Lys Gly Arg Pro Pro Pro Lys Gly Gly Gly Gly Gly Gly Gly Ser Gly 35 40 45 Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Glu Ser Lys Tyr Gly Pro 50 55 60 Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val 65 70 75 80 Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 85 90 95 Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 100 105 110 Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 115 120 125 Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 130 135 140 Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 145 150 155 160 Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 165 170 175 Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 180 185 190 Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 195 200 205 Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 210 215 220 Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 225 230 235 240 Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 245 250 255 Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 260 265 270 His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Gly Gly 275 280 285 Gly Ser Gly Ser Ala His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln 290 295 300 Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Cys 305 310 315 320 Gln Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly 325 330 335 Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys 340 345 350 Pro Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys 355 360 365 Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu 370 375 380 Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr 385 390 395 400 Gln Ser Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Cys Lys Ser 405 410 415 Pro His Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu 420 425 430 Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro 435 440 445 Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly Ser 450 455 460 Gln Gly Arg Ser Pro Ser Tyr Ala Ser 465 470 <210> 151 <211> 473 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 151 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Gln Leu Leu Glu Lys 1 5 10 15 Arg Leu Ala His Leu Phe Ile Glu Trp Leu Ile Ala Gly Gly His Ser 20 25 30 Ser Gly Arg Tyr Ser Pro Lys Gly Gly Gly Gly Gly Gly Gly Ser Gly 35 40 45 Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Glu Ser Lys Tyr Gly Pro 50 55 60 Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val 65 70 75 80 Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 85 90 95 Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 100 105 110 Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 115 120 125 Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 130 135 140 Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 145 150 155 160 Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 165 170 175 Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 180 185 190 Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 195 200 205 Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 210 215 220 Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 225 230 235 240 Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 245 250 255 Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 260 265 270 His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Gly Gly 275 280 285 Gly Ser Gly Ser Ala His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln 290 295 300 Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Cys 305 310 315 320 Gln Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly 325 330 335 Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys 340 345 350 Pro Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys 355 360 365 Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu 370 375 380 Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr 385 390 395 400 Gln Ser Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Cys Lys Ser 405 410 415 Pro His Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu 420 425 430 Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro 435 440 445 Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly Ser 450 455 460 Gln Gly Arg Ser Pro Ser Tyr Ala Ser 465 470 <210> 152 <211> 473 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 152 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Gln Leu Leu Glu Lys 1 5 10 15 Arg Leu Ala His Leu Phe Ile Glu Trp Leu Leu Ala Gly Gly His Ser 20 25 30 Ser Ile Arg Pro Pro Pro Lys Gly Gly Gly Gly Gly Gly Gly Ser Gly 35 40 45 Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Glu Ser Lys Tyr Gly Pro 50 55 60 Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val 65 70 75 80 Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 85 90 95 Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 100 105 110 Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 115 120 125 Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 130 135 140 Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 145 150 155 160 Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 165 170 175 Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 180 185 190 Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 195 200 205 Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 210 215 220 Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 225 230 235 240 Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 245 250 255 Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 260 265 270 His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Gly Gly 275 280 285 Gly Ser Gly Ser Ala His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln 290 295 300 Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Cys 305 310 315 320 Gln Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly 325 330 335 Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys 340 345 350 Pro Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys 355 360 365 Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu 370 375 380 Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr 385 390 395 400 Gln Ser Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Cys Lys Ser 405 410 415 Pro His Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu 420 425 430 Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro 435 440 445 Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly Ser 450 455 460 Gln Gly Arg Ser Pro Ser Tyr Ala Ser 465 470 <210> 153 <211> 473 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 153 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Gln Leu Leu Glu Lys 1 5 10 15 Arg Leu Ala His Leu Phe Ile Glu Trp Leu Leu Ala Gly Gly His Ser 20 25 30 Ser Ile Lys Pro Pro Pro Lys Gly Gly Gly Gly Gly Gly Gly Ser Gly 35 40 45 Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Glu Ser Lys Tyr Gly Pro 50 55 60 Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val 65 70 75 80 Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 85 90 95 Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 100 105 110 Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 115 120 125 Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 130 135 140 Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 145 150 155 160 Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 165 170 175 Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 180 185 190 Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 195 200 205 Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 210 215 220 Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 225 230 235 240 Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 245 250 255 Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 260 265 270 His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Gly Gly 275 280 285 Gly Ser Gly Ser Ala His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln 290 295 300 Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Cys 305 310 315 320 Gln Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly 325 330 335 Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys 340 345 350 Pro Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys 355 360 365 Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu 370 375 380 Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr 385 390 395 400 Gln Ser Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Cys Lys Ser 405 410 415 Pro His Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu 420 425 430 Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro 435 440 445 Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly Ser 450 455 460 Gln Gly Arg Ser Pro Ser Tyr Ala Ser 465 470 <210> 154 <211> 473 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 154 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Gln Leu Leu Glu Lys 1 5 10 15 Glu Ala Ala His Leu Phe Ile Glu Trp Leu Ile Ala Gly Gly His Ser 20 25 30 Ser Ile Lys Pro Pro Pro Lys Gly Gly Gly Gly Gly Gly Gly Ser Gly 35 40 45 Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Glu Ser Lys Tyr Gly Pro 50 55 60 Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val 65 70 75 80 Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 85 90 95 Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 100 105 110 Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 115 120 125 Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 130 135 140 Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 145 150 155 160 Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 165 170 175 Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 180 185 190 Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 195 200 205 Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 210 215 220 Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 225 230 235 240 Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 245 250 255 Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 260 265 270 His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Gly Gly 275 280 285 Gly Ser Gly Ser Ala His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln 290 295 300 Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Cys 305 310 315 320 Gln Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly 325 330 335 Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys 340 345 350 Pro Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys 355 360 365 Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu 370 375 380 Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr 385 390 395 400 Gln Ser Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Cys Lys Ser 405 410 415 Pro His Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu 420 425 430 Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro 435 440 445 Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly Ser 450 455 460 Gln Gly Arg Ser Pro Ser Tyr Ala Ser 465 470 <210> 155 <211> 473 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 155 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Gln Leu Leu Glu Lys 1 5 10 15 Arg Leu Ala His Leu Phe Ile Glu Trp Leu Ile Ala Gly Gly His Ser 20 25 30 Lys Gly Arg Leu Pro Pro Lys Gly Gly Gly Gly Gly Gly Gly Ser Gly 35 40 45 Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Glu Ser Lys Tyr Gly Pro 50 55 60 Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val 65 70 75 80 Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 85 90 95 Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 100 105 110 Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 115 120 125 Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 130 135 140 Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 145 150 155 160 Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 165 170 175 Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 180 185 190 Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 195 200 205 Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 210 215 220 Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 225 230 235 240 Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 245 250 255 Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 260 265 270 His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Gly Gly 275 280 285 Gly Ser Gly Ser Ala His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln 290 295 300 Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Cys 305 310 315 320 Gln Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly 325 330 335 Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys 340 345 350 Pro Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys 355 360 365 Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu 370 375 380 Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr 385 390 395 400 Gln Ser Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Cys Lys Ser 405 410 415 Pro His Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu 420 425 430 Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro 435 440 445 Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly Ser 450 455 460 Gln Gly Arg Ser Pro Ser Tyr Ala Ser 465 470 <210> 156 <211> 473 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 156 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Gln Leu Leu Glu Lys 1 5 10 15 Arg Leu Ala His Leu Phe Ile Glu Trp Leu Ile Ala Gly Gly His Ser 20 25 30 Ser Gly Arg Leu Ser Pro Lys Gly Gly Gly Gly Gly Gly Gly Ser Gly 35 40 45 Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Glu Ser Lys Tyr Gly Pro 50 55 60 Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val 65 70 75 80 Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 85 90 95 Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 100 105 110 Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 115 120 125 Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 130 135 140 Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 145 150 155 160 Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 165 170 175 Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 180 185 190 Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 195 200 205 Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 210 215 220 Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 225 230 235 240 Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 245 250 255 Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 260 265 270 His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Gly Gly 275 280 285 Gly Ser Gly Ser Ala His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln 290 295 300 Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Cys 305 310 315 320 Gln Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly 325 330 335 Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys 340 345 350 Pro Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys 355 360 365 Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu 370 375 380 Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr 385 390 395 400 Gln Ser Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Cys Lys Ser 405 410 415 Pro His Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu 420 425 430 Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro 435 440 445 Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly Ser 450 455 460 Gln Gly Arg Ser Pro Ser Tyr Ala Ser 465 470 <210> 157 <211> 473 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 157 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Gln Leu Leu Glu Lys 1 5 10 15 Arg Leu Ala His Leu Phe Ile Glu Trp Leu Ile Ala Gly Gly Pro Ser 20 25 30 Lys Gly Arg Pro Pro Pro Lys Gly Gly Gly Gly Gly Gly Gly Ser Gly 35 40 45 Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Glu Ser Lys Tyr Gly Pro 50 55 60 Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val 65 70 75 80 Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 85 90 95 Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 100 105 110 Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 115 120 125 Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 130 135 140 Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 145 150 155 160 Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 165 170 175 Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 180 185 190 Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 195 200 205 Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 210 215 220 Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 225 230 235 240 Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 245 250 255 Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 260 265 270 His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Gly Gly 275 280 285 Gly Ser Gly Ser Ala His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln 290 295 300 Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Cys 305 310 315 320 Gln Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly 325 330 335 Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys 340 345 350 Pro Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys 355 360 365 Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu 370 375 380 Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr 385 390 395 400 Gln Ser Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Cys Lys Ser 405 410 415 Pro His Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu 420 425 430 Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro 435 440 445 Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly Ser 450 455 460 Gln Gly Arg Ser Pro Ser Tyr Ala Ser 465 470 <210> 158 <211> 473 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 158 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Gln Leu Leu Glu Lys 1 5 10 15 Arg Leu Ala His Leu Phe Ile Glu Trp Leu Ile Lys Gly Gly His Ser 20 25 30 Lys Gly Arg Pro Pro Pro Lys Gly Gly Gly Gly Gly Gly Gly Ser Gly 35 40 45 Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Glu Ser Lys Tyr Gly Pro 50 55 60 Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val 65 70 75 80 Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 85 90 95 Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 100 105 110 Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 115 120 125 Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 130 135 140 Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 145 150 155 160 Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 165 170 175 Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 180 185 190 Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 195 200 205 Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 210 215 220 Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 225 230 235 240 Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 245 250 255 Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 260 265 270 His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Gly Gly 275 280 285 Gly Ser Gly Ser Ala His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln 290 295 300 Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Cys 305 310 315 320 Gln Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly 325 330 335 Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys 340 345 350 Pro Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys 355 360 365 Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu 370 375 380 Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr 385 390 395 400 Gln Ser Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Cys Lys Ser 405 410 415 Pro His Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu 420 425 430 Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro 435 440 445 Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly Ser 450 455 460 Gln Gly Arg Ser Pro Ser Tyr Ala Ser 465 470 <210> 159 <211> 473 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 159 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Gln Leu Leu Glu Lys 1 5 10 15 Arg Ala Ala His Leu Phe Ile Glu Trp Leu Ile Ala Gly Gly His Lys 20 25 30 Lys Gly Lys Pro Pro Pro Lys Gly Gly Gly Gly Gly Gly Gly Ser Gly 35 40 45 Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Glu Ser Lys Tyr Gly Pro 50 55 60 Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val 65 70 75 80 Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 85 90 95 Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 100 105 110 Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 115 120 125 Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 130 135 140 Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 145 150 155 160 Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 165 170 175 Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 180 185 190 Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 195 200 205 Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 210 215 220 Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 225 230 235 240 Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 245 250 255 Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 260 265 270 His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Gly Gly 275 280 285 Gly Ser Gly Ser Ala His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln 290 295 300 Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Cys 305 310 315 320 Gln Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly 325 330 335 Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys 340 345 350 Pro Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys 355 360 365 Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu 370 375 380 Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr 385 390 395 400 Gln Ser Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Cys Lys Ser 405 410 415 Pro His Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu 420 425 430 Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro 435 440 445 Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly Ser 450 455 460 Gln Gly Arg Ser Pro Ser Tyr Ala Ser 465 470 <210> 160 <211> 473 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 160 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Gln Leu Leu Glu Lys 1 5 10 15 Arg Ala Ala His Leu Phe Ile Glu Trp Leu Ile Ala Gly Gly His Ser 20 25 30 Ser Gly Arg Tyr Pro Pro Lys Gly Gly Gly Gly Gly Gly Gly Ser Gly 35 40 45 Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Glu Ser Lys Tyr Gly Pro 50 55 60 Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val 65 70 75 80 Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 85 90 95 Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 100 105 110 Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 115 120 125 Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 130 135 140 Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 145 150 155 160 Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 165 170 175 Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 180 185 190 Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 195 200 205 Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 210 215 220 Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 225 230 235 240 Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 245 250 255 Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 260 265 270 His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Gly Gly 275 280 285 Gly Ser Gly Ser Ala His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln 290 295 300 Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Cys 305 310 315 320 Gln Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly 325 330 335 Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys 340 345 350 Pro Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys 355 360 365 Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu 370 375 380 Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr 385 390 395 400 Gln Ser Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Cys Lys Ser 405 410 415 Pro His Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu 420 425 430 Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro 435 440 445 Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly Ser 450 455 460 Gln Gly Arg Ser Pro Ser Tyr Ala Ser 465 470 <210> 161 <211> 473 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 161 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Lys Gln Leu Ala Lys 1 5 10 15 Arg Leu Val Arg Leu Phe Ile Glu Trp Leu Ile Ala Gly Gly His Ser 20 25 30 Ser Gly Lys Pro Pro Pro Lys Gly Gly Gly Gly Gly Gly Gly Ser Gly 35 40 45 Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Glu Ser Lys Tyr Gly Pro 50 55 60 Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val 65 70 75 80 Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 85 90 95 Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 100 105 110 Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 115 120 125 Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 130 135 140 Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 145 150 155 160 Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 165 170 175 Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 180 185 190 Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 195 200 205 Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 210 215 220 Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 225 230 235 240 Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 245 250 255 Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 260 265 270 His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Gly Gly 275 280 285 Gly Ser Gly Ser Ala His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln 290 295 300 Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Cys 305 310 315 320 Gln Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly 325 330 335 Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys 340 345 350 Pro Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys 355 360 365 Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu 370 375 380 Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr 385 390 395 400 Gln Ser Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Cys Lys Ser 405 410 415 Pro His Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu 420 425 430 Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro 435 440 445 Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly Ser 450 455 460 Gln Gly Arg Ser Pro Ser Tyr Ala Ser 465 470 <210> 162 <211> 473 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 162 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Lys Gln Leu Ala Lys 1 5 10 15 Arg Leu Ala His Leu Phe Ile Glu Trp Leu Ile Ala Gly Gly His Ser 20 25 30 Ser Gly Lys Pro Pro Pro Lys Gly Gly Gly Gly Gly Gly Gly Ser Gly 35 40 45 Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Glu Ser Lys Tyr Gly Pro 50 55 60 Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val 65 70 75 80 Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 85 90 95 Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 100 105 110 Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 115 120 125 Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 130 135 140 Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 145 150 155 160 Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 165 170 175 Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 180 185 190 Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 195 200 205 Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 210 215 220 Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 225 230 235 240 Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 245 250 255 Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 260 265 270 His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Gly Gly 275 280 285 Gly Ser Gly Ser Ala His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln 290 295 300 Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Cys 305 310 315 320 Gln Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly 325 330 335 Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys 340 345 350 Pro Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys 355 360 365 Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu 370 375 380 Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr 385 390 395 400 Gln Ser Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Cys Lys Ser 405 410 415 Pro His Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu 420 425 430 Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro 435 440 445 Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly Ser 450 455 460 Gln Gly Arg Ser Pro Ser Tyr Ala Ser 465 470 <210> 163 <211> 471 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 163 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Lys Gln Leu Ala Glu 1 5 10 15 Glu Ala Val Gln Leu Phe Ile Glu Trp Leu Leu Ala Gly Gly Pro Ser 20 25 30 Lys Glu Ile Ile Ser Gly Gly Gly Gly Gly Gly Gly Ser Gly Gly Gly 35 40 45 Gly Ser Gly Gly Gly Gly Ser Ala Glu Ser Lys Tyr Gly Pro Pro Cys 50 55 60 Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val Phe Leu 65 70 75 80 Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 85 90 95 Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln 100 105 110 Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 115 120 125 Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu 130 135 140 Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 145 150 155 160 Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys 165 170 175 Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 180 185 190 Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 195 200 205 Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 210 215 220 Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 225 230 235 240 Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln 245 250 255 Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 260 265 270 His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Gly Gly Gly Ser 275 280 285 Gly Ser Ala His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe Gly 290 295 300 Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Cys Gln Thr 305 310 315 320 Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly Ala Ala 325 330 335 Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys Pro Gly 340 345 350 Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys Gln Arg 355 360 365 Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu Ala Cys 370 375 380 Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr Gln Ser 385 390 395 400 Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Cys Lys Ser Pro His 405 410 415 Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu Pro Gly 420 425 430 Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro Gln Pro 435 440 445 Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly Ser Gln Gly 450 455 460 Arg Ser Pro Ser Tyr Ala Ser 465 470 <210> 164 <211> 473 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 164 His Ser Glu Gly Thr Phe Thr Ser Asp Lys Ser Lys Gln Leu Ala Lys 1 5 10 15 Arg Leu Val Arg Leu Phe Ile Glu Trp Leu Ile Lys Gly Gly His Ser 20 25 30 Ser Gly Lys Pro Pro Pro Lys Gly Gly Gly Gly Gly Gly Gly Ser Gly 35 40 45 Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Glu Ser Lys Tyr Gly Pro 50 55 60 Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val 65 70 75 80 Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 85 90 95 Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 100 105 110 Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 115 120 125 Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 130 135 140 Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 145 150 155 160 Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 165 170 175 Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 180 185 190 Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 195 200 205 Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 210 215 220 Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 225 230 235 240 Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 245 250 255 Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 260 265 270 His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Gly Gly 275 280 285 Gly Ser Gly Ser Ala His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln 290 295 300 Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Cys 305 310 315 320 Gln Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly 325 330 335 Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys 340 345 350 Pro Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys 355 360 365 Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu 370 375 380 Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr 385 390 395 400 Gln Ser Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Cys Lys Ser 405 410 415 Pro His Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu 420 425 430 Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro 435 440 445 Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly Ser 450 455 460 Gln Gly Arg Ser Pro Ser Tyr Ala Ser 465 470 <210> 165 <211> 473 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 165 His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Leu Ala Lys 1 5 10 15 Arg Leu Val Arg Leu Phe Ile Glu Trp Leu Ile Lys Gly Gly His Ser 20 25 30 Ser Gly Lys Pro Pro Pro Lys Gly Gly Gly Gly Gly Gly Gly Ser Gly 35 40 45 Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Glu Ser Lys Tyr Gly Pro 50 55 60 Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val 65 70 75 80 Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 85 90 95 Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 100 105 110 Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 115 120 125 Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 130 135 140 Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 145 150 155 160 Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 165 170 175 Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 180 185 190 Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 195 200 205 Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 210 215 220 Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 225 230 235 240 Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 245 250 255 Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 260 265 270 His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Gly Gly 275 280 285 Gly Ser Gly Ser Ala His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln 290 295 300 Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Cys 305 310 315 320 Gln Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly 325 330 335 Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys 340 345 350 Pro Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys 355 360 365 Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu 370 375 380 Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr 385 390 395 400 Gln Ser Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Cys Lys Ser 405 410 415 Pro His Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu 420 425 430 Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro 435 440 445 Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly Ser 450 455 460 Gln Gly Arg Ser Pro Ser Tyr Ala Ser 465 470 <210> 166 <211> 473 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 166 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Lys Gln Leu Ala Lys 1 5 10 15 Arg Leu Val Arg Glu Phe Ile Glu Trp Leu Ile Lys Gly Gly His Ser 20 25 30 Ser Gly Lys Pro Pro Pro Lys Gly Gly Gly Gly Gly Gly Gly Ser Gly 35 40 45 Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Glu Ser Lys Tyr Gly Pro 50 55 60 Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val 65 70 75 80 Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 85 90 95 Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 100 105 110 Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 115 120 125 Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 130 135 140 Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 145 150 155 160 Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 165 170 175 Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 180 185 190 Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 195 200 205 Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 210 215 220 Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 225 230 235 240 Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 245 250 255 Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 260 265 270 His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Gly Gly 275 280 285 Gly Ser Gly Ser Ala His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln 290 295 300 Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Cys 305 310 315 320 Gln Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly 325 330 335 Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys 340 345 350 Pro Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys 355 360 365 Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu 370 375 380 Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr 385 390 395 400 Gln Ser Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Cys Lys Ser 405 410 415 Pro His Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu 420 425 430 Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro 435 440 445 Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly Ser 450 455 460 Gln Gly Arg Ser Pro Ser Tyr Ala Ser 465 470 <210> 167 <211> 473 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 167 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Lys Gln Leu Ala Lys 1 5 10 15 Arg Leu Val Arg His Phe Ile Glu Trp Leu Ile Lys Gly Gly His Ser 20 25 30 Ser Gly Lys Pro Pro Pro Lys Gly Gly Gly Gly Gly Gly Gly Ser Gly 35 40 45 Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Glu Ser Lys Tyr Gly Pro 50 55 60 Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val 65 70 75 80 Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 85 90 95 Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 100 105 110 Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 115 120 125 Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 130 135 140 Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 145 150 155 160 Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 165 170 175 Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 180 185 190 Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 195 200 205 Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 210 215 220 Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 225 230 235 240 Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 245 250 255 Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 260 265 270 His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Gly Gly 275 280 285 Gly Ser Gly Ser Ala His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln 290 295 300 Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Cys 305 310 315 320 Gln Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly 325 330 335 Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys 340 345 350 Pro Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys 355 360 365 Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu 370 375 380 Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr 385 390 395 400 Gln Ser Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Cys Lys Ser 405 410 415 Pro His Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu 420 425 430 Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro 435 440 445 Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly Ser 450 455 460 Gln Gly Arg Ser Pro Ser Tyr Ala Ser 465 470 <210> 168 <211> 473 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 168 His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Leu Ala Lys 1 5 10 15 Arg Leu Val Arg Glu Phe Ile Glu Trp Leu Ile Lys Gly Gly His Ser 20 25 30 Ser Gly Lys Pro Pro Pro Lys Gly Gly Gly Gly Gly Gly Gly Ser Gly 35 40 45 Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Glu Ser Lys Tyr Gly Pro 50 55 60 Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val 65 70 75 80 Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 85 90 95 Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 100 105 110 Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 115 120 125 Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 130 135 140 Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 145 150 155 160 Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 165 170 175 Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 180 185 190 Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 195 200 205 Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 210 215 220 Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 225 230 235 240 Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 245 250 255 Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 260 265 270 His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Gly Gly 275 280 285 Gly Ser Gly Ser Ala His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln 290 295 300 Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Cys 305 310 315 320 Gln Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly 325 330 335 Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys 340 345 350 Pro Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys 355 360 365 Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu 370 375 380 Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr 385 390 395 400 Gln Ser Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Cys Lys Ser 405 410 415 Pro His Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu 420 425 430 Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro 435 440 445 Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly Ser 450 455 460 Gln Gly Arg Ser Pro Ser Tyr Ala Ser 465 470 <210> 169 <211> 473 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 169 His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Leu Ala Lys 1 5 10 15 Arg Leu Val Arg Glu Phe Ile Glu Trp Leu Ile Glu Gly Gly His Ser 20 25 30 Ser Gly Lys Pro Pro Pro Lys Gly Gly Gly Gly Gly Gly Gly Ser Gly 35 40 45 Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Glu Ser Lys Tyr Gly Pro 50 55 60 Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val 65 70 75 80 Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 85 90 95 Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 100 105 110 Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 115 120 125 Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 130 135 140 Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 145 150 155 160 Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 165 170 175 Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 180 185 190 Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 195 200 205 Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 210 215 220 Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 225 230 235 240 Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 245 250 255 Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 260 265 270 His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Gly Gly 275 280 285 Gly Ser Gly Ser Ala His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln 290 295 300 Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Cys 305 310 315 320 Gln Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly 325 330 335 Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys 340 345 350 Pro Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys 355 360 365 Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu 370 375 380 Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr 385 390 395 400 Gln Ser Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Cys Lys Ser 405 410 415 Pro His Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu 420 425 430 Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro 435 440 445 Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly Ser 450 455 460 Gln Gly Arg Ser Pro Ser Tyr Ala Ser 465 470 <210> 170 <211> 473 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 170 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Lys Gln Leu Ala Lys 1 5 10 15 Arg Leu Val Arg Glu Phe Ile Glu Trp Leu Ile Glu Gly Gly His Ser 20 25 30 Ser Gly Lys Pro Pro Pro Lys Gly Gly Gly Gly Gly Gly Gly Ser Gly 35 40 45 Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Glu Ser Lys Tyr Gly Pro 50 55 60 Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val 65 70 75 80 Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 85 90 95 Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 100 105 110 Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 115 120 125 Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 130 135 140 Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 145 150 155 160 Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 165 170 175 Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 180 185 190 Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 195 200 205 Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 210 215 220 Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 225 230 235 240 Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 245 250 255 Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 260 265 270 His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Gly Gly 275 280 285 Gly Ser Gly Ser Ala His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln 290 295 300 Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Cys 305 310 315 320 Gln Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly 325 330 335 Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys 340 345 350 Pro Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys 355 360 365 Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu 370 375 380 Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr 385 390 395 400 Gln Ser Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Cys Lys Ser 405 410 415 Pro His Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu 420 425 430 Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro 435 440 445 Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly Ser 450 455 460 Gln Gly Arg Ser Pro Ser Tyr Ala Ser 465 470 <210> 171 <211> 473 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 171 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Lys Gln Leu Ala Lys 1 5 10 15 Arg Leu Val Arg Leu Phe Ile Glu Trp Leu Ile Lys Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser Gly Gly Gly Gly Gly Gly Gly Ser Gly 35 40 45 Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Glu Ser Lys Tyr Gly Pro 50 55 60 Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val 65 70 75 80 Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 85 90 95 Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 100 105 110 Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 115 120 125 Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 130 135 140 Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 145 150 155 160 Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 165 170 175 Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 180 185 190 Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 195 200 205 Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 210 215 220 Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 225 230 235 240 Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 245 250 255 Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 260 265 270 His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Gly Gly 275 280 285 Gly Ser Gly Ser Ala His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln 290 295 300 Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Cys 305 310 315 320 Gln Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly 325 330 335 Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys 340 345 350 Pro Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys 355 360 365 Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu 370 375 380 Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr 385 390 395 400 Gln Ser Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Cys Lys Ser 405 410 415 Pro His Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu 420 425 430 Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro 435 440 445 Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly Ser 450 455 460 Gln Gly Arg Ser Pro Ser Tyr Ala Ser 465 470 <210> 172 <211> 473 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 172 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Lys Gln Leu Ala Lys 1 5 10 15 Arg Leu Val Arg Leu Phe Ile Glu Trp Leu Ile Lys Gly Gly His Ser 20 25 30 Ser Gly Lys Pro Pro Pro Ser Gly Gly Gly Gly Gly Gly Gly Ser Gly 35 40 45 Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Glu Ser Lys Tyr Gly Pro 50 55 60 Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val 65 70 75 80 Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 85 90 95 Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 100 105 110 Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 115 120 125 Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 130 135 140 Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 145 150 155 160 Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 165 170 175 Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 180 185 190 Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 195 200 205 Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 210 215 220 Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 225 230 235 240 Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 245 250 255 Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 260 265 270 His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Gly Gly 275 280 285 Gly Ser Gly Ser Ala His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln 290 295 300 Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Cys 305 310 315 320 Gln Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly 325 330 335 Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys 340 345 350 Pro Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys 355 360 365 Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu 370 375 380 Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr 385 390 395 400 Gln Ser Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Cys Lys Ser 405 410 415 Pro His Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu 420 425 430 Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro 435 440 445 Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly Ser 450 455 460 Gln Gly Arg Ser Pro Ser Tyr Ala Ser 465 470 <210> 173 <211> 473 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 173 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Lys Gln Leu Ala Lys 1 5 10 15 Arg Leu Val Arg Leu Phe Val Gln Trp Leu Ile Lys Gly Gly His Ser 20 25 30 Ser Gly Lys Pro Pro Pro Lys Gly Gly Gly Gly Gly Gly Gly Ser Gly 35 40 45 Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Glu Ser Lys Tyr Gly Pro 50 55 60 Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val 65 70 75 80 Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 85 90 95 Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 100 105 110 Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 115 120 125 Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 130 135 140 Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 145 150 155 160 Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 165 170 175 Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 180 185 190 Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 195 200 205 Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 210 215 220 Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 225 230 235 240 Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 245 250 255 Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 260 265 270 His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Gly Gly 275 280 285 Gly Ser Gly Ser Ala His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln 290 295 300 Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Cys 305 310 315 320 Gln Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly 325 330 335 Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys 340 345 350 Pro Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys 355 360 365 Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu 370 375 380 Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr 385 390 395 400 Gln Ser Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Cys Lys Ser 405 410 415 Pro His Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu 420 425 430 Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro 435 440 445 Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly Ser 450 455 460 Gln Gly Arg Ser Pro Ser Tyr Ala Ser 465 470 <210> 174 <211> 473 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 174 His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Leu Ala Lys 1 5 10 15 Arg Leu Val Arg Glu Phe Ile Glu Trp Leu Ile Glu Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser Gly Gly Gly Gly Gly Gly Gly Ser Gly 35 40 45 Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Glu Ser Lys Tyr Gly Pro 50 55 60 Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val 65 70 75 80 Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 85 90 95 Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 100 105 110 Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 115 120 125 Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 130 135 140 Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 145 150 155 160 Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 165 170 175 Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 180 185 190 Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 195 200 205 Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 210 215 220 Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 225 230 235 240 Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 245 250 255 Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 260 265 270 His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Gly Gly 275 280 285 Gly Ser Gly Ser Ala His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln 290 295 300 Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Cys 305 310 315 320 Gln Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly 325 330 335 Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys 340 345 350 Pro Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys 355 360 365 Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu 370 375 380 Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr 385 390 395 400 Gln Ser Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Cys Lys Ser 405 410 415 Pro His Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu 420 425 430 Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro 435 440 445 Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly Ser 450 455 460 Gln Gly Arg Ser Pro Ser Tyr Ala Ser 465 470 <210> 175 <211> 471 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 175 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Lys Gln Leu Ala Lys 1 5 10 15 Glu Ala Val Gln Leu Phe Ile Glu Trp Leu Leu Ala Gly Gly Pro Lys 20 25 30 Lys Ile Arg Tyr Ser Gly Gly Gly Gly Gly Gly Gly Ser Gly Gly Gly 35 40 45 Gly Ser Gly Gly Gly Gly Ser Ala Glu Ser Lys Tyr Gly Pro Pro Cys 50 55 60 Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val Phe Leu 65 70 75 80 Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 85 90 95 Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln 100 105 110 Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 115 120 125 Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu 130 135 140 Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 145 150 155 160 Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys 165 170 175 Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 180 185 190 Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 195 200 205 Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 210 215 220 Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 225 230 235 240 Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln 245 250 255 Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 260 265 270 His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Gly Gly Gly Ser 275 280 285 Gly Ser Ala His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe Gly 290 295 300 Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Cys Gln Thr 305 310 315 320 Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly Ala Ala 325 330 335 Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys Pro Gly 340 345 350 Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys Gln Arg 355 360 365 Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu Ala Cys 370 375 380 Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr Gln Ser 385 390 395 400 Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Cys Lys Ser Pro His 405 410 415 Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu Pro Gly 420 425 430 Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro Gln Pro 435 440 445 Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly Ser Gln Gly 450 455 460 Arg Ser Pro Ser Tyr Ala Ser 465 470 <210> 176 <211> 471 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 176 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Lys Gln Leu Ala Glu 1 5 10 15 Arg Ala Val Gln Leu Phe Ile Glu Trp Leu Leu Ala Gly Gly Pro Lys 20 25 30 Lys Ile Arg Tyr Ser Gly Gly Gly Gly Gly Gly Gly Ser Gly Gly Gly 35 40 45 Gly Ser Gly Gly Gly Gly Ser Ala Glu Ser Lys Tyr Gly Pro Pro Cys 50 55 60 Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val Phe Leu 65 70 75 80 Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 85 90 95 Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln 100 105 110 Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 115 120 125 Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu 130 135 140 Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 145 150 155 160 Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys 165 170 175 Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 180 185 190 Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 195 200 205 Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 210 215 220 Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 225 230 235 240 Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln 245 250 255 Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 260 265 270 His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Gly Gly Gly Ser 275 280 285 Gly Ser Ala His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe Gly 290 295 300 Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Cys Gln Thr 305 310 315 320 Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly Ala Ala 325 330 335 Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys Pro Gly 340 345 350 Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys Gln Arg 355 360 365 Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu Ala Cys 370 375 380 Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr Gln Ser 385 390 395 400 Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Cys Lys Ser Pro His 405 410 415 Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu Pro Gly 420 425 430 Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro Gln Pro 435 440 445 Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly Ser Gln Gly 450 455 460 Arg Ser Pro Ser Tyr Ala Ser 465 470 <210> 177 <211> 471 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 177 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Lys Gln Leu Ala Lys 1 5 10 15 Arg Ala Val Gln Leu Phe Ile Glu Trp Leu Leu Ala Gly Gly Pro Lys 20 25 30 Lys Ile Arg Tyr Ser Gly Gly Gly Gly Gly Gly Gly Ser Gly Gly Gly 35 40 45 Gly Ser Gly Gly Gly Gly Ser Ala Glu Ser Lys Tyr Gly Pro Pro Cys 50 55 60 Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val Phe Leu 65 70 75 80 Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 85 90 95 Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln 100 105 110 Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 115 120 125 Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu 130 135 140 Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 145 150 155 160 Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys 165 170 175 Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 180 185 190 Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 195 200 205 Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 210 215 220 Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 225 230 235 240 Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln 245 250 255 Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 260 265 270 His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Gly Gly Gly Ser 275 280 285 Gly Ser Ala His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe Gly 290 295 300 Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Cys Gln Thr 305 310 315 320 Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly Ala Ala 325 330 335 Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys Pro Gly 340 345 350 Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys Gln Arg 355 360 365 Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu Ala Cys 370 375 380 Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr Gln Ser 385 390 395 400 Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Cys Lys Ser Pro His 405 410 415 Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu Pro Gly 420 425 430 Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro Gln Pro 435 440 445 Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly Ser Gln Gly 450 455 460 Arg Ser Pro Ser Tyr Ala Ser 465 470 <210> 178 <211> 471 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 178 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Lys Gln Leu Ala Lys 1 5 10 15 Arg Leu Val Gln Leu Phe Ile Glu Trp Leu Leu Ala Gly Gly Pro Lys 20 25 30 Lys Ile Arg Tyr Ser Gly Gly Gly Gly Gly Gly Gly Ser Gly Gly Gly 35 40 45 Gly Ser Gly Gly Gly Gly Ser Ala Glu Ser Lys Tyr Gly Pro Pro Cys 50 55 60 Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val Phe Leu 65 70 75 80 Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 85 90 95 Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln 100 105 110 Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 115 120 125 Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu 130 135 140 Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 145 150 155 160 Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys 165 170 175 Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 180 185 190 Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 195 200 205 Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 210 215 220 Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 225 230 235 240 Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln 245 250 255 Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 260 265 270 His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Gly Gly Gly Ser 275 280 285 Gly Ser Ala His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe Gly 290 295 300 Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Cys Gln Thr 305 310 315 320 Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly Ala Ala 325 330 335 Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys Pro Gly 340 345 350 Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys Gln Arg 355 360 365 Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu Ala Cys 370 375 380 Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr Gln Ser 385 390 395 400 Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Cys Lys Ser Pro His 405 410 415 Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu Pro Gly 420 425 430 Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro Gln Pro 435 440 445 Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly Ser Gln Gly 450 455 460 Arg Ser Pro Ser Tyr Ala Ser 465 470 <210> 179 <211> 471 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 179 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Lys Gln Leu Ala Lys 1 5 10 15 Glu Leu Val Gln Leu Phe Ile Glu Trp Leu Leu Ala Gly Gly Pro Lys 20 25 30 Lys Ile Arg Tyr Ser Gly Gly Gly Gly Gly Gly Gly Ser Gly Gly Gly 35 40 45 Gly Ser Gly Gly Gly Gly Ser Ala Glu Ser Lys Tyr Gly Pro Pro Cys 50 55 60 Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val Phe Leu 65 70 75 80 Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 85 90 95 Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln 100 105 110 Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 115 120 125 Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu 130 135 140 Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 145 150 155 160 Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys 165 170 175 Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 180 185 190 Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 195 200 205 Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 210 215 220 Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 225 230 235 240 Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln 245 250 255 Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 260 265 270 His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Gly Gly Gly Ser 275 280 285 Gly Ser Ala His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe Gly 290 295 300 Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Cys Gln Thr 305 310 315 320 Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly Ala Ala 325 330 335 Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys Pro Gly 340 345 350 Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys Gln Arg 355 360 365 Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu Ala Cys 370 375 380 Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr Gln Ser 385 390 395 400 Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Cys Lys Ser Pro His 405 410 415 Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu Pro Gly 420 425 430 Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro Gln Pro 435 440 445 Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly Ser Gln Gly 450 455 460 Arg Ser Pro Ser Tyr Ala Ser 465 470 <210> 180 <211> 471 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 180 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Lys Gln Leu Ala Glu 1 5 10 15 Arg Leu Val Gln Leu Phe Ile Glu Trp Leu Leu Ala Gly Gly Pro Lys 20 25 30 Lys Ile Arg Tyr Ser Gly Gly Gly Gly Gly Gly Gly Ser Gly Gly Gly 35 40 45 Gly Ser Gly Gly Gly Gly Ser Ala Glu Ser Lys Tyr Gly Pro Pro Cys 50 55 60 Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val Phe Leu 65 70 75 80 Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 85 90 95 Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln 100 105 110 Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 115 120 125 Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu 130 135 140 Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 145 150 155 160 Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys 165 170 175 Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 180 185 190 Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 195 200 205 Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 210 215 220 Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 225 230 235 240 Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln 245 250 255 Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 260 265 270 His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Gly Gly Gly Ser 275 280 285 Gly Ser Ala His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe Gly 290 295 300 Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Cys Gln Thr 305 310 315 320 Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly Ala Ala 325 330 335 Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys Pro Gly 340 345 350 Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys Gln Arg 355 360 365 Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu Ala Cys 370 375 380 Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr Gln Ser 385 390 395 400 Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Cys Lys Ser Pro His 405 410 415 Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu Pro Gly 420 425 430 Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro Gln Pro 435 440 445 Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly Ser Gln Gly 450 455 460 Arg Ser Pro Ser Tyr Ala Ser 465 470 <210> 181 <211> 473 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 181 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Lys Gln Leu Ala Lys 1 5 10 15 Arg Leu Ala Gln Glu Phe Ile Glu Trp Leu Ile Lys Gly Gly His Ser 20 25 30 Ser Gly Lys Pro Pro Pro Lys Gly Gly Gly Gly Gly Gly Gly Ser Gly 35 40 45 Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Glu Ser Lys Tyr Gly Pro 50 55 60 Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val 65 70 75 80 Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 85 90 95 Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 100 105 110 Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 115 120 125 Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 130 135 140 Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 145 150 155 160 Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 165 170 175 Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 180 185 190 Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 195 200 205 Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 210 215 220 Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 225 230 235 240 Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 245 250 255 Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 260 265 270 His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Gly Gly 275 280 285 Gly Ser Gly Ser Ala His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln 290 295 300 Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Cys 305 310 315 320 Gln Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly 325 330 335 Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys 340 345 350 Pro Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys 355 360 365 Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu 370 375 380 Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr 385 390 395 400 Gln Ser Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Cys Lys Ser 405 410 415 Pro His Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu 420 425 430 Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro 435 440 445 Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly Ser 450 455 460 Gln Gly Arg Ser Pro Ser Tyr Ala Ser 465 470 <210> 182 <211> 473 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 182 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Lys Gln Leu Ala Glu 1 5 10 15 Arg Leu Val Arg Leu Phe Ile Glu Trp Leu Ile Ala Gly Gly His Ser 20 25 30 Ser Gly Lys Pro Pro Pro Lys Gly Gly Gly Gly Gly Gly Gly Ser Gly 35 40 45 Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Glu Ser Lys Tyr Gly Pro 50 55 60 Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val 65 70 75 80 Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 85 90 95 Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 100 105 110 Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 115 120 125 Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 130 135 140 Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 145 150 155 160 Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 165 170 175 Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 180 185 190 Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 195 200 205 Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 210 215 220 Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 225 230 235 240 Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 245 250 255 Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 260 265 270 His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Gly Gly 275 280 285 Gly Ser Gly Ser Ala His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln 290 295 300 Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Cys 305 310 315 320 Gln Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly 325 330 335 Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys 340 345 350 Pro Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys 355 360 365 Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu 370 375 380 Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr 385 390 395 400 Gln Ser Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Cys Lys Ser 405 410 415 Pro His Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu 420 425 430 Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro 435 440 445 Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly Ser 450 455 460 Gln Gly Arg Ser Pro Ser Tyr Ala Ser 465 470 <210> 183 <211> 473 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 183 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Lys Gln Leu Ala Glu 1 5 10 15 Arg Leu Val Arg Glu Phe Ile Glu Trp Leu Ile Ala Gly Gly His Ser 20 25 30 Ser Gly Lys Pro Pro Pro Lys Gly Gly Gly Gly Gly Gly Gly Ser Gly 35 40 45 Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Glu Ser Lys Tyr Gly Pro 50 55 60 Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val 65 70 75 80 Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 85 90 95 Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 100 105 110 Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 115 120 125 Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 130 135 140 Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 145 150 155 160 Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 165 170 175 Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 180 185 190 Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 195 200 205 Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 210 215 220 Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 225 230 235 240 Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 245 250 255 Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 260 265 270 His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Gly Gly 275 280 285 Gly Ser Gly Ser Ala His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln 290 295 300 Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Cys 305 310 315 320 Gln Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly 325 330 335 Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys 340 345 350 Pro Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys 355 360 365 Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu 370 375 380 Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr 385 390 395 400 Gln Ser Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Cys Lys Ser 405 410 415 Pro His Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu 420 425 430 Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro 435 440 445 Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly Ser 450 455 460 Gln Gly Arg Ser Pro Ser Tyr Ala Ser 465 470 <210> 184 <211> 473 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 184 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Lys Gln Leu Ala Glu 1 5 10 15 Arg Leu Val Lys Leu Phe Ile Glu Trp Leu Ile Ala Gly Gly His Ser 20 25 30 Ser Gly Lys Pro Pro Pro Lys Gly Gly Gly Gly Gly Gly Gly Ser Gly 35 40 45 Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Glu Ser Lys Tyr Gly Pro 50 55 60 Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val 65 70 75 80 Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 85 90 95 Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 100 105 110 Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 115 120 125 Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 130 135 140 Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 145 150 155 160 Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 165 170 175 Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 180 185 190 Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 195 200 205 Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 210 215 220 Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 225 230 235 240 Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 245 250 255 Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 260 265 270 His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Gly Gly 275 280 285 Gly Ser Gly Ser Ala His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln 290 295 300 Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Cys 305 310 315 320 Gln Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly 325 330 335 Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys 340 345 350 Pro Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys 355 360 365 Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu 370 375 380 Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr 385 390 395 400 Gln Ser Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Cys Lys Ser 405 410 415 Pro His Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu 420 425 430 Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro 435 440 445 Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly Ser 450 455 460 Gln Gly Arg Ser Pro Ser Tyr Ala Ser 465 470 <210> 185 <211> 473 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 185 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Lys Gln Leu Ala Glu 1 5 10 15 Arg Leu Ala Arg Glu Phe Ile Glu Trp Leu Ile Ala Gly Gly His Ser 20 25 30 Ser Gly Lys Pro Pro Pro Lys Gly Gly Gly Gly Gly Gly Gly Ser Gly 35 40 45 Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Glu Ser Lys Tyr Gly Pro 50 55 60 Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val 65 70 75 80 Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 85 90 95 Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 100 105 110 Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 115 120 125 Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 130 135 140 Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 145 150 155 160 Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 165 170 175 Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 180 185 190 Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 195 200 205 Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 210 215 220 Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 225 230 235 240 Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 245 250 255 Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 260 265 270 His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Gly Gly 275 280 285 Gly Ser Gly Ser Ala His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln 290 295 300 Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Cys 305 310 315 320 Gln Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly 325 330 335 Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys 340 345 350 Pro Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys 355 360 365 Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu 370 375 380 Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr 385 390 395 400 Gln Ser Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Cys Lys Ser 405 410 415 Pro His Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu 420 425 430 Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro 435 440 445 Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly Ser 450 455 460 Gln Gly Arg Ser Pro Ser Tyr Ala Ser 465 470 <210> 186 <211> 473 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 186 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Lys Gln Leu Ala Glu 1 5 10 15 Arg Leu Ala Lys Leu Phe Ile Glu Trp Leu Ile Ala Gly Gly His Ser 20 25 30 Ser Gly Lys Pro Pro Pro Lys Gly Gly Gly Gly Gly Gly Gly Ser Gly 35 40 45 Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Glu Ser Lys Tyr Gly Pro 50 55 60 Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val 65 70 75 80 Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 85 90 95 Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 100 105 110 Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 115 120 125 Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 130 135 140 Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 145 150 155 160 Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 165 170 175 Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 180 185 190 Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 195 200 205 Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 210 215 220 Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 225 230 235 240 Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 245 250 255 Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 260 265 270 His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Gly Gly 275 280 285 Gly Ser Gly Ser Ala His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln 290 295 300 Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Cys 305 310 315 320 Gln Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly 325 330 335 Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys 340 345 350 Pro Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys 355 360 365 Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu 370 375 380 Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr 385 390 395 400 Gln Ser Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Cys Lys Ser 405 410 415 Pro His Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu 420 425 430 Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro 435 440 445 Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly Ser 450 455 460 Gln Gly Arg Ser Pro Ser Tyr Ala Ser 465 470 <210> 187 <211> 473 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 187 His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Leu Ala Glu 1 5 10 15 Arg Leu Val Arg Leu Phe Ile Glu Trp Leu Ile Lys Gly Gly His Ser 20 25 30 Ser Gly Lys Pro Pro Pro Lys Gly Gly Gly Gly Gly Gly Gly Ser Gly 35 40 45 Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Glu Ser Lys Tyr Gly Pro 50 55 60 Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val 65 70 75 80 Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 85 90 95 Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 100 105 110 Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 115 120 125 Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 130 135 140 Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 145 150 155 160 Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 165 170 175 Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 180 185 190 Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 195 200 205 Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 210 215 220 Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 225 230 235 240 Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 245 250 255 Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 260 265 270 His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Gly Gly 275 280 285 Gly Ser Gly Ser Ala His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln 290 295 300 Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Cys 305 310 315 320 Gln Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly 325 330 335 Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys 340 345 350 Pro Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys 355 360 365 Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu 370 375 380 Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr 385 390 395 400 Gln Ser Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Cys Lys Ser 405 410 415 Pro His Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu 420 425 430 Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro 435 440 445 Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly Ser 450 455 460 Gln Gly Arg Ser Pro Ser Tyr Ala Ser 465 470 <210> 188 <211> 473 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 188 His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Ile Gln Leu Ala Lys 1 5 10 15 Arg Leu Ala Gln Leu Phe Ile Glu Trp Leu Ile Lys Gly Gly His Ser 20 25 30 Ser Gly Lys Pro Pro Pro Lys Gly Gly Gly Gly Gly Gly Gly Ser Gly 35 40 45 Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Glu Ser Lys Tyr Gly Pro 50 55 60 Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val 65 70 75 80 Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 85 90 95 Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 100 105 110 Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 115 120 125 Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 130 135 140 Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 145 150 155 160 Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 165 170 175 Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 180 185 190 Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 195 200 205 Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 210 215 220 Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 225 230 235 240 Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 245 250 255 Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 260 265 270 His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Gly Gly 275 280 285 Gly Ser Gly Ser Ala His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln 290 295 300 Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Cys 305 310 315 320 Gln Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly 325 330 335 Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys 340 345 350 Pro Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys 355 360 365 Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu 370 375 380 Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr 385 390 395 400 Gln Ser Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Cys Lys Ser 405 410 415 Pro His Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu 420 425 430 Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro 435 440 445 Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly Ser 450 455 460 Gln Gly Arg Ser Pro Ser Tyr Ala Ser 465 470 <210> 189 <211> 473 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 189 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Lys Gln Leu Glu Lys 1 5 10 15 Glu Leu Val Arg Leu Phe Tyr Glu Trp Leu Lys Lys Gly Gly His Ser 20 25 30 Ser Ile Lys Pro Pro Pro Lys Gly Gly Gly Gly Gly Gly Gly Ser Gly 35 40 45 Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Glu Ser Lys Tyr Gly Pro 50 55 60 Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val 65 70 75 80 Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 85 90 95 Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 100 105 110 Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 115 120 125 Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 130 135 140 Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 145 150 155 160 Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 165 170 175 Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 180 185 190 Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 195 200 205 Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 210 215 220 Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 225 230 235 240 Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 245 250 255 Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 260 265 270 His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Gly Gly 275 280 285 Gly Ser Gly Ser Ala His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln 290 295 300 Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Cys 305 310 315 320 Gln Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly 325 330 335 Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys 340 345 350 Pro Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys 355 360 365 Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu 370 375 380 Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr 385 390 395 400 Gln Ser Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Cys Lys Ser 405 410 415 Pro His Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu 420 425 430 Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro 435 440 445 Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly Ser 450 455 460 Gln Gly Arg Ser Pro Ser Tyr Ala Ser 465 470 <210> 190 <211> 473 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 190 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Lys Gln Leu Glu Lys 1 5 10 15 Glu Leu Val Arg Leu Phe Tyr Glu Trp Leu Lys Ala Gly Gly His Ser 20 25 30 Lys Gln Lys Pro Pro Pro Lys Gly Gly Gly Gly Gly Gly Gly Ser Gly 35 40 45 Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Glu Ser Lys Tyr Gly Pro 50 55 60 Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val 65 70 75 80 Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 85 90 95 Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 100 105 110 Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 115 120 125 Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 130 135 140 Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 145 150 155 160 Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 165 170 175 Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 180 185 190 Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 195 200 205 Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 210 215 220 Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 225 230 235 240 Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 245 250 255 Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 260 265 270 His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Gly Gly 275 280 285 Gly Ser Gly Ser Ala His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln 290 295 300 Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Cys 305 310 315 320 Gln Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly 325 330 335 Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys 340 345 350 Pro Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys 355 360 365 Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu 370 375 380 Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr 385 390 395 400 Gln Ser Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Cys Lys Ser 405 410 415 Pro His Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu 420 425 430 Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro 435 440 445 Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly Ser 450 455 460 Gln Gly Arg Ser Pro Ser Tyr Ala Ser 465 470 <210> 191 <211> 473 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 191 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Lys Gln Leu Glu Lys 1 5 10 15 Glu Leu Val Arg Leu Phe Tyr Glu Trp Leu Lys Ala Gly Gly His Ser 20 25 30 Lys Ile Lys Pro Pro Pro Lys Gly Gly Gly Gly Gly Gly Gly Ser Gly 35 40 45 Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Glu Ser Lys Tyr Gly Pro 50 55 60 Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val 65 70 75 80 Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 85 90 95 Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 100 105 110 Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 115 120 125 Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 130 135 140 Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 145 150 155 160 Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 165 170 175 Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 180 185 190 Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 195 200 205 Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 210 215 220 Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 225 230 235 240 Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 245 250 255 Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 260 265 270 His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Gly Gly 275 280 285 Gly Ser Gly Ser Ala His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln 290 295 300 Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Cys 305 310 315 320 Gln Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly 325 330 335 Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys 340 345 350 Pro Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys 355 360 365 Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu 370 375 380 Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr 385 390 395 400 Gln Ser Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Cys Lys Ser 405 410 415 Pro His Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu 420 425 430 Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro 435 440 445 Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly Ser 450 455 460 Gln Gly Arg Ser Pro Ser Tyr Ala Ser 465 470 <210> 192 <211> 473 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 192 His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Leu Glu Glu 1 5 10 15 Arg Leu Ala Arg Leu Phe Tyr Glu Trp Leu Ile Ala Gly Gly His Ser 20 25 30 Ser Gln Lys Pro Pro Pro Lys Gly Gly Gly Gly Gly Gly Gly Ser Gly 35 40 45 Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Glu Ser Lys Tyr Gly Pro 50 55 60 Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val 65 70 75 80 Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 85 90 95 Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 100 105 110 Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 115 120 125 Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 130 135 140 Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 145 150 155 160 Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 165 170 175 Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 180 185 190 Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 195 200 205 Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 210 215 220 Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 225 230 235 240 Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 245 250 255 Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 260 265 270 His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Gly Gly 275 280 285 Gly Ser Gly Ser Ala His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln 290 295 300 Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Cys 305 310 315 320 Gln Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly 325 330 335 Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys 340 345 350 Pro Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys 355 360 365 Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu 370 375 380 Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr 385 390 395 400 Gln Ser Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Cys Lys Ser 405 410 415 Pro His Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu 420 425 430 Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro 435 440 445 Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly Ser 450 455 460 Gln Gly Arg Ser Pro Ser Tyr Ala Ser 465 470 <210> 193 <211> 473 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 193 His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Leu Glu Lys 1 5 10 15 Glu Leu Val Arg Leu Phe Tyr Glu Trp Leu Ile Asn Gly Gly His Ser 20 25 30 Ser Gln Lys Pro Pro Pro Lys Gly Gly Gly Gly Gly Gly Gly Ser Gly 35 40 45 Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Glu Ser Lys Tyr Gly Pro 50 55 60 Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val 65 70 75 80 Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 85 90 95 Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 100 105 110 Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 115 120 125 Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 130 135 140 Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 145 150 155 160 Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 165 170 175 Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 180 185 190 Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 195 200 205 Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 210 215 220 Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 225 230 235 240 Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 245 250 255 Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 260 265 270 His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Gly Gly 275 280 285 Gly Ser Gly Ser Ala His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln 290 295 300 Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Cys 305 310 315 320 Gln Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly 325 330 335 Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys 340 345 350 Pro Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys 355 360 365 Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu 370 375 380 Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr 385 390 395 400 Gln Ser Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Cys Lys Ser 405 410 415 Pro His Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu 420 425 430 Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro 435 440 445 Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly Ser 450 455 460 Gln Gly Arg Ser Pro Ser Tyr Ala Ser 465 470 <210> 194 <211> 473 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 194 His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Leu Glu Lys 1 5 10 15 Glu Leu Val Arg Leu Phe Tyr Glu Trp Leu Ile Asn Gly Gly His Lys 20 25 30 Ser Gly Lys Pro Pro Pro Lys Gly Gly Gly Gly Gly Gly Gly Ser Gly 35 40 45 Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Glu Ser Lys Tyr Gly Pro 50 55 60 Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val 65 70 75 80 Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 85 90 95 Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 100 105 110 Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 115 120 125 Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 130 135 140 Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 145 150 155 160 Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 165 170 175 Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 180 185 190 Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 195 200 205 Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 210 215 220 Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 225 230 235 240 Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 245 250 255 Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 260 265 270 His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Gly Gly 275 280 285 Gly Ser Gly Ser Ala His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln 290 295 300 Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Cys 305 310 315 320 Gln Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly 325 330 335 Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys 340 345 350 Pro Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys 355 360 365 Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu 370 375 380 Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr 385 390 395 400 Gln Ser Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Cys Lys Ser 405 410 415 Pro His Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu 420 425 430 Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro 435 440 445 Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly Ser 450 455 460 Gln Gly Arg Ser Pro Ser Tyr Ala Ser 465 470 <210> 195 <211> 473 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 195 His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Leu Glu Lys 1 5 10 15 Glu Leu Val Arg Leu Phe Tyr Glu Trp Leu Ile Asn Gly Gly His Ser 20 25 30 Lys Gly Lys Pro Pro Pro Lys Gly Gly Gly Gly Gly Gly Gly Ser Gly 35 40 45 Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Glu Ser Lys Tyr Gly Pro 50 55 60 Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val 65 70 75 80 Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 85 90 95 Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 100 105 110 Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 115 120 125 Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 130 135 140 Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 145 150 155 160 Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 165 170 175 Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 180 185 190 Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 195 200 205 Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 210 215 220 Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 225 230 235 240 Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 245 250 255 Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 260 265 270 His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Gly Gly 275 280 285 Gly Ser Gly Ser Ala His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln 290 295 300 Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Cys 305 310 315 320 Gln Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly 325 330 335 Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys 340 345 350 Pro Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys 355 360 365 Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu 370 375 380 Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr 385 390 395 400 Gln Ser Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Cys Lys Ser 405 410 415 Pro His Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu 420 425 430 Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro 435 440 445 Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly Ser 450 455 460 Gln Gly Arg Ser Pro Ser Tyr Ala Ser 465 470 <210> 196 <211> 473 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 196 His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Leu Glu Lys 1 5 10 15 Glu Leu Val Arg Leu Phe Tyr Glu Trp Leu Ile Asn Gly Gly Pro Ser 20 25 30 Ser Gly Lys Pro Pro Pro Lys Gly Gly Gly Gly Gly Gly Gly Ser Gly 35 40 45 Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Glu Ser Lys Tyr Gly Pro 50 55 60 Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val 65 70 75 80 Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 85 90 95 Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 100 105 110 Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 115 120 125 Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 130 135 140 Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 145 150 155 160 Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 165 170 175 Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 180 185 190 Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 195 200 205 Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 210 215 220 Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 225 230 235 240 Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 245 250 255 Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 260 265 270 His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Gly Gly 275 280 285 Gly Ser Gly Ser Ala His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln 290 295 300 Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Cys 305 310 315 320 Gln Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly 325 330 335 Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys 340 345 350 Pro Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys 355 360 365 Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu 370 375 380 Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr 385 390 395 400 Gln Ser Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Cys Lys Ser 405 410 415 Pro His Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu 420 425 430 Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro 435 440 445 Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly Ser 450 455 460 Gln Gly Arg Ser Pro Ser Tyr Ala Ser 465 470 <210> 197 <211> 473 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 197 His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Leu Glu Lys 1 5 10 15 Glu Leu Val Arg Leu Phe Tyr Glu Trp Leu Ile Asn Gly Gly His Ser 20 25 30 Ser Gly Lys Pro Pro Pro Lys Gly Gly Gly Gly Gly Gly Gly Ser Gly 35 40 45 Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Glu Ser Lys Tyr Gly Pro 50 55 60 Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val 65 70 75 80 Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 85 90 95 Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 100 105 110 Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 115 120 125 Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 130 135 140 Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 145 150 155 160 Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 165 170 175 Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 180 185 190 Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 195 200 205 Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 210 215 220 Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 225 230 235 240 Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 245 250 255 Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 260 265 270 His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Gly Gly 275 280 285 Gly Ser Gly Ser Ala His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln 290 295 300 Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Cys 305 310 315 320 Gln Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly 325 330 335 Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys 340 345 350 Pro Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys 355 360 365 Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu 370 375 380 Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr 385 390 395 400 Gln Ser Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Cys Lys Ser 405 410 415 Pro His Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu 420 425 430 Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro 435 440 445 Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly Ser 450 455 460 Gln Gly Arg Ser Pro Ser Tyr Ala Ser 465 470 <210> 198 <211> 473 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 198 His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Leu Glu Lys 1 5 10 15 Glu Leu Val Arg Leu Phe Tyr Glu Trp Leu Ile Ala Gly Gly His Ser 20 25 30 Ser Gln Arg Pro Pro Pro Lys Gly Gly Gly Gly Gly Gly Gly Ser Gly 35 40 45 Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Glu Ser Lys Tyr Gly Pro 50 55 60 Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val 65 70 75 80 Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 85 90 95 Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 100 105 110 Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 115 120 125 Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 130 135 140 Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 145 150 155 160 Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 165 170 175 Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 180 185 190 Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 195 200 205 Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 210 215 220 Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 225 230 235 240 Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 245 250 255 Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 260 265 270 His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Gly Gly 275 280 285 Gly Ser Gly Ser Ala His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln 290 295 300 Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Cys 305 310 315 320 Gln Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly 325 330 335 Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys 340 345 350 Pro Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys 355 360 365 Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu 370 375 380 Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr 385 390 395 400 Gln Ser Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Cys Lys Ser 405 410 415 Pro His Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu 420 425 430 Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro 435 440 445 Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly Ser 450 455 460 Gln Gly Arg Ser Pro Ser Tyr Ala Ser 465 470 <210> 199 <211> 473 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 199 His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Leu Glu Lys 1 5 10 15 Glu Leu Val Arg Leu Phe Tyr Glu Trp Leu Lys Ala Gly Gly His Ser 20 25 30 Ser Gly Lys Pro Pro Pro Lys Gly Gly Gly Gly Gly Gly Gly Ser Gly 35 40 45 Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Glu Ser Lys Tyr Gly Pro 50 55 60 Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val 65 70 75 80 Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 85 90 95 Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 100 105 110 Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 115 120 125 Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 130 135 140 Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 145 150 155 160 Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 165 170 175 Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 180 185 190 Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 195 200 205 Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 210 215 220 Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 225 230 235 240 Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 245 250 255 Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 260 265 270 His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Gly Gly 275 280 285 Gly Ser Gly Ser Ala His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln 290 295 300 Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Cys 305 310 315 320 Gln Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly 325 330 335 Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys 340 345 350 Pro Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys 355 360 365 Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu 370 375 380 Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr 385 390 395 400 Gln Ser Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Cys Lys Ser 405 410 415 Pro His Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu 420 425 430 Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro 435 440 445 Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly Ser 450 455 460 Gln Gly Arg Ser Pro Ser Tyr Ala Ser 465 470 <210> 200 <211> 473 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 200 His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Leu Glu Lys 1 5 10 15 Glu Leu Val Arg Leu Phe Tyr Glu Trp Leu Ile Lys Gly Gly His Ser 20 25 30 Ser Gly Arg Pro Pro Pro Lys Gly Gly Gly Gly Gly Gly Gly Ser Gly 35 40 45 Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Glu Ser Lys Tyr Gly Pro 50 55 60 Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val 65 70 75 80 Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 85 90 95 Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 100 105 110 Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 115 120 125 Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 130 135 140 Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 145 150 155 160 Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 165 170 175 Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 180 185 190 Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 195 200 205 Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 210 215 220 Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 225 230 235 240 Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 245 250 255 Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 260 265 270 His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Gly Gly 275 280 285 Gly Ser Gly Ser Ala His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln 290 295 300 Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Cys 305 310 315 320 Gln Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly 325 330 335 Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys 340 345 350 Pro Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys 355 360 365 Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu 370 375 380 Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr 385 390 395 400 Gln Ser Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Cys Lys Ser 405 410 415 Pro His Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu 420 425 430 Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro 435 440 445 Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly Ser 450 455 460 Gln Gly Arg Ser Pro Ser Tyr Ala Ser 465 470 <210> 201 <211> 473 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 201 His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Leu Glu Lys 1 5 10 15 Glu Leu Val Arg Leu Phe Tyr Glu Trp Leu Ile Lys Gly Gly His Ser 20 25 30 Ser Gln Lys Pro Pro Pro Lys Gly Gly Gly Gly Gly Gly Gly Ser Gly 35 40 45 Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Glu Ser Lys Tyr Gly Pro 50 55 60 Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val 65 70 75 80 Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 85 90 95 Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 100 105 110 Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 115 120 125 Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 130 135 140 Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 145 150 155 160 Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 165 170 175 Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 180 185 190 Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 195 200 205 Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 210 215 220 Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 225 230 235 240 Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 245 250 255 Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 260 265 270 His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Gly Gly 275 280 285 Gly Ser Gly Ser Ala His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln 290 295 300 Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Cys 305 310 315 320 Gln Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly 325 330 335 Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys 340 345 350 Pro Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys 355 360 365 Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu 370 375 380 Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr 385 390 395 400 Gln Ser Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Cys Lys Ser 405 410 415 Pro His Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu 420 425 430 Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro 435 440 445 Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly Ser 450 455 460 Gln Gly Arg Ser Pro Ser Tyr Ala Ser 465 470 <210> 202 <211> 473 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 202 His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Leu Glu Lys 1 5 10 15 Glu Leu Val Arg Leu Phe Tyr Glu Trp Leu Ile Lys Gly Gly His Ser 20 25 30 Ser Ile Lys Pro Pro Pro Lys Gly Gly Gly Gly Gly Gly Gly Ser Gly 35 40 45 Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Glu Ser Lys Tyr Gly Pro 50 55 60 Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val 65 70 75 80 Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 85 90 95 Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 100 105 110 Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 115 120 125 Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 130 135 140 Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 145 150 155 160 Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 165 170 175 Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 180 185 190 Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 195 200 205 Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 210 215 220 Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 225 230 235 240 Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 245 250 255 Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 260 265 270 His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Gly Gly 275 280 285 Gly Ser Gly Ser Ala His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln 290 295 300 Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Cys 305 310 315 320 Gln Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly 325 330 335 Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys 340 345 350 Pro Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys 355 360 365 Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu 370 375 380 Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr 385 390 395 400 Gln Ser Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Cys Lys Ser 405 410 415 Pro His Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu 420 425 430 Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro 435 440 445 Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly Ser 450 455 460 Gln Gly Arg Ser Pro Ser Tyr Ala Ser 465 470 <210> 203 <211> 473 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 203 His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Leu Glu Lys 1 5 10 15 Glu Leu Val Arg Leu Phe Tyr Glu Trp Leu Ile Lys Gly Gly His Lys 20 25 30 Ser Gly Lys Pro Pro Pro Lys Gly Gly Gly Gly Gly Gly Gly Ser Gly 35 40 45 Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Glu Ser Lys Tyr Gly Pro 50 55 60 Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val 65 70 75 80 Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 85 90 95 Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 100 105 110 Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 115 120 125 Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 130 135 140 Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 145 150 155 160 Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 165 170 175 Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 180 185 190 Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 195 200 205 Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 210 215 220 Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 225 230 235 240 Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 245 250 255 Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 260 265 270 His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Gly Gly 275 280 285 Gly Ser Gly Ser Ala His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln 290 295 300 Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Cys 305 310 315 320 Gln Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly 325 330 335 Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys 340 345 350 Pro Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys 355 360 365 Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu 370 375 380 Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr 385 390 395 400 Gln Ser Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Cys Lys Ser 405 410 415 Pro His Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu 420 425 430 Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro 435 440 445 Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly Ser 450 455 460 Gln Gly Arg Ser Pro Ser Tyr Ala Ser 465 470 <210> 204 <211> 473 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 204 His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Leu Glu Lys 1 5 10 15 Glu Leu Val Arg Leu Phe Tyr Glu Trp Leu Ile Lys Gly Gly His Ser 20 25 30 Lys Gly Lys Pro Pro Pro Lys Gly Gly Gly Gly Gly Gly Gly Ser Gly 35 40 45 Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Glu Ser Lys Tyr Gly Pro 50 55 60 Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val 65 70 75 80 Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 85 90 95 Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 100 105 110 Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 115 120 125 Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 130 135 140 Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 145 150 155 160 Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 165 170 175 Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 180 185 190 Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 195 200 205 Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 210 215 220 Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 225 230 235 240 Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 245 250 255 Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 260 265 270 His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Gly Gly 275 280 285 Gly Ser Gly Ser Ala His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln 290 295 300 Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Cys 305 310 315 320 Gln Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly 325 330 335 Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys 340 345 350 Pro Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys 355 360 365 Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu 370 375 380 Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr 385 390 395 400 Gln Ser Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Cys Lys Ser 405 410 415 Pro His Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu 420 425 430 Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro 435 440 445 Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly Ser 450 455 460 Gln Gly Arg Ser Pro Ser Tyr Ala Ser 465 470 <210> 205 <211> 473 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 205 His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Leu Glu Lys 1 5 10 15 Glu Leu Val Arg Leu Phe Tyr Glu Trp Leu Ile Ala Gly Gly His Lys 20 25 30 Ser Gln Lys Pro Pro Pro Lys Gly Gly Gly Gly Gly Gly Gly Ser Gly 35 40 45 Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Glu Ser Lys Tyr Gly Pro 50 55 60 Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val 65 70 75 80 Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 85 90 95 Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 100 105 110 Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 115 120 125 Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 130 135 140 Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 145 150 155 160 Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 165 170 175 Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 180 185 190 Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 195 200 205 Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 210 215 220 Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 225 230 235 240 Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 245 250 255 Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 260 265 270 His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Gly Gly 275 280 285 Gly Ser Gly Ser Ala His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln 290 295 300 Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Cys 305 310 315 320 Gln Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly 325 330 335 Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys 340 345 350 Pro Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys 355 360 365 Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu 370 375 380 Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr 385 390 395 400 Gln Ser Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Cys Lys Ser 405 410 415 Pro His Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu 420 425 430 Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro 435 440 445 Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly Ser 450 455 460 Gln Gly Arg Ser Pro Ser Tyr Ala Ser 465 470 <210> 206 <211> 473 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 206 His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Leu Glu Lys 1 5 10 15 Arg Leu Val Arg Leu Phe Tyr Glu Trp Leu Leu Asn Gly Gly His Ser 20 25 30 Ser Gln Lys Pro Pro Pro Lys Gly Gly Gly Gly Gly Gly Gly Ser Gly 35 40 45 Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Glu Ser Lys Tyr Gly Pro 50 55 60 Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val 65 70 75 80 Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 85 90 95 Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 100 105 110 Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 115 120 125 Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 130 135 140 Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 145 150 155 160 Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 165 170 175 Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 180 185 190 Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 195 200 205 Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 210 215 220 Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 225 230 235 240 Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 245 250 255 Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 260 265 270 His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Gly Gly 275 280 285 Gly Ser Gly Ser Ala His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln 290 295 300 Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Cys 305 310 315 320 Gln Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly 325 330 335 Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys 340 345 350 Pro Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys 355 360 365 Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu 370 375 380 Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr 385 390 395 400 Gln Ser Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Cys Lys Ser 405 410 415 Pro His Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu 420 425 430 Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro 435 440 445 Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly Ser 450 455 460 Gln Gly Arg Ser Pro Ser Tyr Ala Ser 465 470 <210> 207 <211> 473 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 207 His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Leu Glu Lys 1 5 10 15 Arg Leu Val Arg Leu Phe Tyr Glu Trp Leu Lys Asn Gly Gly His Ser 20 25 30 Ser Gly Lys Pro Pro Pro Lys Gly Gly Gly Gly Gly Gly Gly Ser Gly 35 40 45 Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Glu Ser Lys Tyr Gly Pro 50 55 60 Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val 65 70 75 80 Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 85 90 95 Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 100 105 110 Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 115 120 125 Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 130 135 140 Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 145 150 155 160 Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 165 170 175 Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 180 185 190 Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 195 200 205 Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 210 215 220 Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 225 230 235 240 Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 245 250 255 Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 260 265 270 His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Gly Gly 275 280 285 Gly Ser Gly Ser Ala His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln 290 295 300 Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Cys 305 310 315 320 Gln Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly 325 330 335 Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys 340 345 350 Pro Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys 355 360 365 Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu 370 375 380 Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr 385 390 395 400 Gln Ser Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Cys Lys Ser 405 410 415 Pro His Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu 420 425 430 Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro 435 440 445 Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly Ser 450 455 460 Gln Gly Arg Ser Pro Ser Tyr Ala Ser 465 470 <210> 208 <211> 473 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 208 Gly His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Lys Gln Leu Glu 1 5 10 15 Glu Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Ala Gly Gly Pro 20 25 30 Lys Lys Ile Arg Tyr Ser Gly Gly Gly Gly Gly Gly Gly Ser Gly Gly 35 40 45 Gly Gly Ser Gly Gly Gly Gly Ser Ala Glu Ser Lys Tyr Gly Pro Pro 50 55 60 Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val Phe 65 70 75 80 Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 85 90 95 Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val 100 105 110 Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 115 120 125 Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val 130 135 140 Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 145 150 155 160 Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser 165 170 175 Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 180 185 190 Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 195 200 205 Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 210 215 220 Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 225 230 235 240 Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp 245 250 255 Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 260 265 270 Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Gly Gly Gly 275 280 285 Ser Gly Ser Ala His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe 290 295 300 Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Cys Gln 305 310 315 320 Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly Ala 325 330 335 Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys Pro 340 345 350 Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys Gln 355 360 365 Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu Ala 370 375 380 Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr Gln 385 390 395 400 Ser Glu Ala His Gly Leu Pro Leu His Leu Cys Gly Asn Lys Ser Pro 405 410 415 His Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu Pro 420 425 430 Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro Gln 435 440 445 Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Tyr Pro Ser 450 455 460 Gln Gly Arg Ser Pro Ser Tyr Ala Ser 465 470 <210> 209 <211> 472 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 209 Gly His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Lys Gln Leu Glu 1 5 10 15 Glu Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Ala Gly Gly Pro 20 25 30 Lys Lys Ile Arg Tyr Ser Gly Gly Gly Gly Gly Gly Gly Ser Gly Gly 35 40 45 Gly Gly Ser Gly Gly Gly Gly Ser Ala Glu Ser Lys Tyr Gly Pro Pro 50 55 60 Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val Phe 65 70 75 80 Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 85 90 95 Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val 100 105 110 Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 115 120 125 Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val 130 135 140 Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 145 150 155 160 Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser 165 170 175 Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 180 185 190 Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 195 200 205 Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 210 215 220 Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 225 230 235 240 Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp 245 250 255 Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 260 265 270 Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Gly Gly Gly 275 280 285 Ser Gly Ser Ala His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe 290 295 300 Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Cys Gln 305 310 315 320 Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly Ala 325 330 335 Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys Pro 340 345 350 Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys Gln 355 360 365 Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu Ala 370 375 380 Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr Gln 385 390 395 400 Ser Glu Ala His Gly Leu Pro Leu His Leu Cys Gly Asn Lys Ser Pro 405 410 415 His Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu Pro 420 425 430 Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro Gln 435 440 445 Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly Ser Gln 450 455 460 Gly Arg Ser Pro Ser Tyr Ala Ser 465 470 <210> 210 <211> 472 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 210 Gly His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Lys Gln Leu Glu 1 5 10 15 Glu Glu Ala Val Gln Leu Phe Ile Glu Trp Leu Lys Ala Gly Gly Pro 20 25 30 Lys Lys Ile Arg Tyr Ser Gly Gly Gly Gly Gly Gly Gly Ser Gly Gly 35 40 45 Gly Gly Ser Gly Gly Gly Gly Ser Ala Glu Ser Lys Tyr Gly Pro Pro 50 55 60 Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val Phe 65 70 75 80 Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 85 90 95 Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val 100 105 110 Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 115 120 125 Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val 130 135 140 Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 145 150 155 160 Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser 165 170 175 Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 180 185 190 Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 195 200 205 Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 210 215 220 Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 225 230 235 240 Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp 245 250 255 Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 260 265 270 Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Gly Gly Gly 275 280 285 Ser Gly Ser Ala His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe 290 295 300 Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Cys Gln 305 310 315 320 Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly Ala 325 330 335 Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys Pro 340 345 350 Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys Gln 355 360 365 Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu Ala 370 375 380 Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr Gln 385 390 395 400 Ser Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Cys Lys Ser Pro 405 410 415 His Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu Pro 420 425 430 Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro Gln 435 440 445 Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly Ser Gln 450 455 460 Gly Arg Ser Pro Ser Tyr Ala Ser 465 470 <210> 211 <211> 472 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 211 Gly His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Leu Glu 1 5 10 15 Glu Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Ala Gly Gly Pro 20 25 30 Lys Lys Ile Arg Tyr Ser Gly Gly Gly Gly Gly Gly Gly Ser Gly Gly 35 40 45 Gly Gly Ser Gly Gly Gly Gly Ser Ala Glu Ser Lys Tyr Gly Pro Pro 50 55 60 Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val Phe 65 70 75 80 Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 85 90 95 Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val 100 105 110 Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 115 120 125 Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val 130 135 140 Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 145 150 155 160 Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser 165 170 175 Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 180 185 190 Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 195 200 205 Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 210 215 220 Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 225 230 235 240 Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp 245 250 255 Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 260 265 270 Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Gly Gly Gly 275 280 285 Ser Gly Ser Ala His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe 290 295 300 Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Cys Gln 305 310 315 320 Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly Ala 325 330 335 Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys Pro 340 345 350 Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys Gln 355 360 365 Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu Ala 370 375 380 Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr Gln 385 390 395 400 Ser Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Cys Lys Ser Pro 405 410 415 His Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu Pro 420 425 430 Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro Gln 435 440 445 Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly Ser Gln 450 455 460 Gly Arg Ser Pro Ser Tyr Ala Ser 465 470 <210> 212 <211> 472 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 212 Gly His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Leu Glu 1 5 10 15 Glu Glu Ala Val Gln Leu Phe Ile Glu Trp Leu Lys Ala Gly Gly Pro 20 25 30 Lys Lys Ile Arg Tyr Ser Gly Gly Gly Gly Gly Gly Gly Ser Gly Gly 35 40 45 Gly Gly Ser Gly Gly Gly Gly Ser Ala Glu Ser Lys Tyr Gly Pro Pro 50 55 60 Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val Phe 65 70 75 80 Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 85 90 95 Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val 100 105 110 Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 115 120 125 Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val 130 135 140 Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 145 150 155 160 Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser 165 170 175 Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 180 185 190 Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 195 200 205 Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 210 215 220 Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 225 230 235 240 Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp 245 250 255 Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 260 265 270 Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Gly Gly Gly 275 280 285 Ser Gly Ser Ala His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe 290 295 300 Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Cys Gln 305 310 315 320 Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly Ala 325 330 335 Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys Pro 340 345 350 Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys Gln 355 360 365 Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu Ala 370 375 380 Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr Gln 385 390 395 400 Ser Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Cys Lys Ser Pro 405 410 415 His Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu Pro 420 425 430 Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro Gln 435 440 445 Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly Ser Gln 450 455 460 Gly Arg Ser Pro Ser Tyr Ala Ser 465 470 <210> 213 <211> 472 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 213 Gly His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Leu Glu 1 5 10 15 Glu Glu Arg Val Arg Leu Phe Ile Glu Trp Leu Lys Ala Gly Gly Pro 20 25 30 Lys Lys Ile Arg Tyr Ser Gly Gly Gly Gly Gly Gly Gly Ser Gly Gly 35 40 45 Gly Gly Ser Gly Gly Gly Gly Ser Ala Glu Ser Lys Tyr Gly Pro Pro 50 55 60 Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val Phe 65 70 75 80 Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 85 90 95 Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val 100 105 110 Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 115 120 125 Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val 130 135 140 Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 145 150 155 160 Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser 165 170 175 Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 180 185 190 Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 195 200 205 Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 210 215 220 Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 225 230 235 240 Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp 245 250 255 Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 260 265 270 Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Gly Gly Gly 275 280 285 Ser Gly Ser Ala His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe 290 295 300 Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Cys Gln 305 310 315 320 Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly Ala 325 330 335 Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys Pro 340 345 350 Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys Gln 355 360 365 Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu Ala 370 375 380 Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr Gln 385 390 395 400 Ser Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Cys Lys Ser Pro 405 410 415 His Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu Pro 420 425 430 Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro Gln 435 440 445 Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly Ser Gln 450 455 460 Gly Arg Ser Pro Ser Tyr Ala Ser 465 470 <210> 214 <211> 473 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 214 His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Leu Glu Glu 1 5 10 15 Glu Arg Val Gln Glu Phe Ile Glu Trp Leu Lys Ala Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser Gly Gly Gly Gly Gly Gly Gly Ser Gly 35 40 45 Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Glu Ser Lys Tyr Gly Pro 50 55 60 Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val 65 70 75 80 Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 85 90 95 Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 100 105 110 Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 115 120 125 Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 130 135 140 Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 145 150 155 160 Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 165 170 175 Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 180 185 190 Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 195 200 205 Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 210 215 220 Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 225 230 235 240 Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 245 250 255 Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 260 265 270 His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Gly Gly 275 280 285 Gly Ser Gly Ser Ala His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln 290 295 300 Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Cys 305 310 315 320 Gln Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly 325 330 335 Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys 340 345 350 Pro Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys 355 360 365 Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu 370 375 380 Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr 385 390 395 400 Gln Ser Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Cys Lys Ser 405 410 415 Pro His Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu 420 425 430 Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro 435 440 445 Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly Ser 450 455 460 Gln Gly Arg Ser Pro Ser Tyr Ala Ser 465 470 <210> 215 <211> 831 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 215 His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Leu Glu Glu 1 5 10 15 Glu Arg Val Gln Leu Phe Ile Glu Trp Leu Lys Ala Thr Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser Gly Gly Gly Gly Gly Gly Gly Ser Gly 35 40 45 Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Asp Ala His Lys Ser Glu 50 55 60 Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 65 70 75 80 Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 85 90 95 His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 100 105 110 Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 115 120 125 Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 130 135 140 Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 145 150 155 160 Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 165 170 175 Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 180 185 190 Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 195 200 205 Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 210 215 220 Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 225 230 235 240 Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 245 250 255 Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 260 265 270 Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 275 280 285 Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 290 295 300 His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 305 310 315 320 Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 325 330 335 Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 340 345 350 Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 355 360 365 Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 370 375 380 Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 385 390 395 400 Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 405 410 415 Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 420 425 430 Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 435 440 445 Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 450 455 460 Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 465 470 475 480 Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 485 490 495 Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 500 505 510 Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 515 520 525 Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 530 535 540 Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 545 550 555 560 Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 565 570 575 Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 580 585 590 His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 595 600 605 Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 610 615 620 Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 625 630 635 640 Leu Gly Leu Gly Gly Gly Ser Gly Ser Ala His Pro Ile Pro Asp Ser 645 650 655 Ser Pro Leu Leu Gln Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr 660 665 670 Thr Asp Asp Ala Cys Gln Thr Glu Ala His Leu Glu Ile Arg Glu Asp 675 680 685 Gly Thr Val Gly Gly Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln 690 695 700 Leu Lys Ala Leu Lys Pro Gly Val Ile Gln Ile Leu Gly Val Lys Thr 705 710 715 720 Ser Arg Phe Leu Cys Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu 725 730 735 His Phe Asp Pro Glu Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp 740 745 750 Gly Tyr Asn Val Tyr Gln Ser Glu Ala His Gly Leu Pro Leu His Leu 755 760 765 Pro Gly Cys Lys Ser Pro His Arg Asp Pro Ala Pro Arg Gly Pro Ala 770 775 780 Arg Phe Leu Pro Leu Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro 785 790 795 800 Gly Ile Leu Ala Pro Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu 805 810 815 Ser Met Val Tyr Pro Ser Gln Gly Arg Ser Pro Ser Tyr Ala Ser 820 825 830 <210> 216 <211> 830 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 216 Gly His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Lys Gln Leu Glu 1 5 10 15 Glu Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Ala Gly Gly Pro 20 25 30 Lys Lys Ile Arg Tyr Ser Gly Gly Gly Gly Gly Gly Gly Ser Gly Gly 35 40 45 Gly Gly Ser Gly Gly Gly Gly Ser Ala Asp Ala His Lys Ser Glu Val 50 55 60 Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu Val 65 70 75 80 Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp His 85 90 95 Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val Ala 100 105 110 Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe Gly 115 120 125 Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu Met 130 135 140 Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe Leu 145 150 155 160 Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro Glu 165 170 175 Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe Leu 180 185 190 Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr Ala 195 200 205 Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr Glu 210 215 220 Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu Asp 225 230 235 240 Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu Lys 245 250 255 Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp Ala 260 265 270 Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu Val 275 280 285 Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys His 290 295 300 Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys Tyr 305 310 315 320 Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys Cys 325 330 335 Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu Asn 340 345 350 Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val Glu 355 360 365 Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe Leu 370 375 380 Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser Val 385 390 395 400 Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu Lys 405 410 415 Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe Asp 420 425 430 Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln Asn 435 440 445 Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala Leu 450 455 460 Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr Leu 465 470 475 480 Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys Lys 485 490 495 His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser Val 500 505 510 Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser Asp 515 520 525 Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro Cys 530 535 540 Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe Asn 545 550 555 560 Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu Lys 565 570 575 Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys His 580 585 590 Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp Phe 595 600 605 Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr Cys 610 615 620 Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala Leu 625 630 635 640 Gly Leu Gly Gly Gly Ser Gly Ser Ala His Pro Ile Pro Asp Ser Ser 645 650 655 Pro Leu Leu Gln Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr 660 665 670 Asp Asp Ala Cys Gln Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly 675 680 685 Thr Val Gly Gly Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu 690 695 700 Lys Ala Leu Lys Pro Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser 705 710 715 720 Arg Phe Leu Cys Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His 725 730 735 Phe Asp Pro Glu Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly 740 745 750 Tyr Asn Val Tyr Gln Ser Glu Ala His Gly Leu Pro Leu His Leu Pro 755 760 765 Gly Cys Lys Ser Pro His Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg 770 775 780 Phe Leu Pro Leu Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly 785 790 795 800 Ile Leu Ala Pro Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser 805 810 815 Met Val Tyr Pro Ser Gln Gly Arg Ser Pro Ser Tyr Ala Ser 820 825 830 <210> 217 <211> 475 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 217 Tyr Ser Glu Gly Thr Phe Thr Ser Asp Leu Ser Ile Leu Cys Glu Lys 1 5 10 15 Arg Ala Val His Glu Phe Ile Glu Trp Leu Ile Ala Gly Gly Pro Ser 20 25 30 Ser Gly Lys Pro Pro Pro Lys Pro Gly Cys Gly Ser Gly Gly Gly Gly 35 40 45 Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Gly Ala Asp Lys Thr 50 55 60 His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser 65 70 75 80 Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 85 90 95 Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 100 105 110 Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 115 120 125 Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 130 135 140 Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 145 150 155 160 Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 165 170 175 Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 180 185 190 Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 195 200 205 Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 210 215 220 Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 225 230 235 240 Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 245 250 255 Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 260 265 270 Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gly 275 280 285 Gly Gly Ser Gly Ser Ala His Pro Ile Pro Asp Ser Ser Pro Leu Leu 290 295 300 Gln Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala 305 310 315 320 Cys Gln Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly 325 330 335 Gly Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu 340 345 350 Lys Pro Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu 355 360 365 Cys Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro 370 375 380 Glu Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val 385 390 395 400 Tyr Gln Ser Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Cys Lys 405 410 415 Ser Pro His Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro 420 425 430 Leu Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala 435 440 445 Pro Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Tyr 450 455 460 Pro Ser Gln Gly Arg Ser Pro Ser Tyr Ala Ser 465 470 475 <210> 218 <211> 445 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 218 Gly His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Lys Gln Leu Glu 1 5 10 15 Glu Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Ala Gly Gly Asp 20 25 30 Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly 35 40 45 Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 50 55 60 Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 65 70 75 80 Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 85 90 95 Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 100 105 110 Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 115 120 125 Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 130 135 140 Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 145 150 155 160 Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 165 170 175 Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 180 185 190 Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 195 200 205 Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 210 215 220 Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 225 230 235 240 Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 245 250 255 Gly Gly Gly Gly Ser Gly Ser Ala His Pro Ile Pro Asp Ser Ser Pro 260 265 270 Leu Leu Gln Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp 275 280 285 Asp Ala Cys Gln Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr 290 295 300 Val Gly Gly Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys 305 310 315 320 Ala Leu Lys Pro Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg 325 330 335 Phe Leu Cys Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe 340 345 350 Asp Pro Glu Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr 355 360 365 Asn Val Tyr Gln Ser Glu Ala His Gly Leu Pro Leu His Leu Pro Gly 370 375 380 Cys Lys Ser Pro His Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe 385 390 395 400 Leu Pro Leu Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile 405 410 415 Leu Ala Pro Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met 420 425 430 Val Tyr Pro Ser Gln Gly Arg Ser Pro Ser Tyr Ala Ser 435 440 445 <210> 219 <211> 464 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 219 Gly His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Lys Gln Leu Glu 1 5 10 15 Glu Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Ala Gly Gly Gly 20 25 30 Gly Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 35 40 45 Ser Ala Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala 50 55 60 Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 65 70 75 80 Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 85 90 95 Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 100 105 110 Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 115 120 125 Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 130 135 140 Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 145 150 155 160 Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 165 170 175 Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 180 185 190 Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 195 200 205 Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 210 215 220 Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 225 230 235 240 Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 245 250 255 Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 260 265 270 Leu Ser Pro Gly Gly Gly Gly Ser Gly Ser Ala His Pro Ile Pro Asp 275 280 285 Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu 290 295 300 Tyr Thr Asp Asp Ala Cys Gln Thr Glu Ala His Leu Glu Ile Arg Glu 305 310 315 320 Asp Gly Thr Val Gly Gly Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu 325 330 335 Gln Leu Lys Ala Leu Lys Pro Gly Val Ile Gln Ile Leu Gly Val Lys 340 345 350 Thr Ser Arg Phe Leu Cys Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser 355 360 365 Leu His Phe Asp Pro Glu Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu 370 375 380 Asp Gly Tyr Asn Val Tyr Gln Ser Glu Ala His Gly Leu Pro Leu His 385 390 395 400 Leu Pro Gly Cys Lys Ser Pro His Arg Asp Pro Ala Pro Arg Gly Pro 405 410 415 Ala Arg Phe Leu Pro Leu Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro 420 425 430 Pro Gly Ile Leu Ala Pro Gln Pro Pro Asp Val Gly Ser Ser Asp Pro 435 440 445 Leu Ser Met Val Tyr Pro Ser Gln Gly Arg Ser Pro Ser Tyr Ala Ser 450 455 460 <210> 220 <211> 460 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 220 Gly His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Lys Gln Leu Glu 1 5 10 15 Glu Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Ala Gly Gly Pro 20 25 30 Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Gly Gly Gly Asp Lys 35 40 45 Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro 50 55 60 Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 65 70 75 80 Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 85 90 95 Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 100 105 110 Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 115 120 125 Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 130 135 140 Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 145 150 155 160 Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 165 170 175 Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 180 185 190 Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 195 200 205 Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 210 215 220 Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 225 230 235 240 Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 245 250 255 Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 260 265 270 Gly Gly Gly Ser Gly Ser Ala His Pro Ile Pro Asp Ser Ser Pro Leu 275 280 285 Leu Gln Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp 290 295 300 Ala Cys Gln Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val 305 310 315 320 Gly Gly Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala 325 330 335 Leu Lys Pro Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe 340 345 350 Leu Cys Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp 355 360 365 Pro Glu Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn 370 375 380 Val Tyr Gln Ser Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Cys 385 390 395 400 Lys Ser Pro His Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu 405 410 415 Pro Leu Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu 420 425 430 Ala Pro Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val 435 440 445 Tyr Pro Ser Gln Gly Arg Ser Pro Ser Tyr Ala Ser 450 455 460 <210> 221 <211> 466 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 221 Gly His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Lys Gln Leu Glu 1 5 10 15 Glu Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Ala Gly Pro Ala 20 25 30 Pro Ala Pro Ala Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Pro Ala 35 40 45 Pro Ala Pro Ala Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 50 55 60 Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 65 70 75 80 Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 85 90 95 Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 100 105 110 Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 115 120 125 Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 130 135 140 Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 145 150 155 160 Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 165 170 175 Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys 180 185 190 Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 195 200 205 Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 210 215 220 Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 225 230 235 240 Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 245 250 255 Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 260 265 270 Leu Ser Leu Ser Pro Gly Gly Gly Gly Ser Gly Ser Ala His Pro Ile 275 280 285 Pro Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln Val Arg Gln Arg 290 295 300 Tyr Leu Tyr Thr Asp Asp Ala Cys Gln Thr Glu Ala His Leu Glu Ile 305 310 315 320 Arg Glu Asp Gly Thr Val Gly Gly Ala Ala Asp Gln Ser Pro Glu Ser 325 330 335 Leu Leu Gln Leu Lys Ala Leu Lys Pro Gly Val Ile Gln Ile Leu Gly 340 345 350 Val Lys Thr Ser Arg Phe Leu Cys Gln Arg Pro Asp Gly Ala Leu Tyr 355 360 365 Gly Ser Leu His Phe Asp Pro Glu Ala Cys Ser Phe Arg Glu Leu Leu 370 375 380 Leu Glu Asp Gly Tyr Asn Val Tyr Gln Ser Glu Ala His Gly Leu Pro 385 390 395 400 Leu His Leu Pro Gly Cys Lys Ser Pro His Arg Asp Pro Ala Pro Arg 405 410 415 Gly Pro Ala Arg Phe Leu Pro Leu Pro Gly Leu Pro Pro Ala Pro Pro 420 425 430 Glu Pro Pro Gly Ile Leu Ala Pro Gln Pro Pro Asp Val Gly Ser Ser 435 440 445 Asp Pro Leu Ser Met Val Tyr Pro Ser Gln Gly Arg Ser Pro Ser Tyr 450 455 460 Ala Ser 465 <210> 222 <211> 464 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 222 Gly His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Lys Gln Leu Glu 1 5 10 15 Glu Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Ala Gly Gly Ala 20 25 30 Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Gly 35 40 45 Gly Gly Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala 50 55 60 Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 65 70 75 80 Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 85 90 95 Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 100 105 110 Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 115 120 125 Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 130 135 140 Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 145 150 155 160 Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 165 170 175 Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 180 185 190 Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 195 200 205 Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 210 215 220 Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 225 230 235 240 Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 245 250 255 Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 260 265 270 Leu Ser Pro Gly Gly Gly Gly Ser Gly Ser Ala His Pro Ile Pro Asp 275 280 285 Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu 290 295 300 Tyr Thr Asp Asp Ala Cys Gln Thr Glu Ala His Leu Glu Ile Arg Glu 305 310 315 320 Asp Gly Thr Val Gly Gly Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu 325 330 335 Gln Leu Lys Ala Leu Lys Pro Gly Val Ile Gln Ile Leu Gly Val Lys 340 345 350 Thr Ser Arg Phe Leu Cys Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser 355 360 365 Leu His Phe Asp Pro Glu Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu 370 375 380 Asp Gly Tyr Asn Val Tyr Gln Ser Glu Ala His Gly Leu Pro Leu His 385 390 395 400 Leu Pro Gly Cys Lys Ser Pro His Arg Asp Pro Ala Pro Arg Gly Pro 405 410 415 Ala Arg Phe Leu Pro Leu Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro 420 425 430 Pro Gly Ile Leu Ala Pro Gln Pro Pro Asp Val Gly Ser Ser Asp Pro 435 440 445 Leu Ser Met Val Tyr Pro Ser Gln Gly Arg Ser Pro Ser Tyr Ala Ser 450 455 460 <210> 223 <211> 489 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 223 Gly His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Lys Gln Leu Glu 1 5 10 15 Glu Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Ala Gly Gly Ala 20 25 30 Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu 35 40 45 Ala Ala Lys Ala Leu Glu Ala Glu Ala Ala Lys Glu Ala Ala Lys Glu 50 55 60 Ala Ala Lys Glu Ala Ala Lys Ala Gly Gly Gly Asp Lys Thr His Thr 65 70 75 80 Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe 85 90 95 Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 100 105 110 Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 115 120 125 Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 130 135 140 Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 145 150 155 160 Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 165 170 175 Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 180 185 190 Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 195 200 205 Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 210 215 220 Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 225 230 235 240 Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 245 250 255 Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 260 265 270 Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 275 280 285 Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly 290 295 300 Ser Gly Ser Ala His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe 305 310 315 320 Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Cys Gln 325 330 335 Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly Ala 340 345 350 Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys Pro 355 360 365 Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys Gln 370 375 380 Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu Ala 385 390 395 400 Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr Gln 405 410 415 Ser Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Cys Lys Ser Pro 420 425 430 His Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu Pro 435 440 445 Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro Gln 450 455 460 Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Tyr Pro Ser 465 470 475 480 Gln Gly Arg Ser Pro Ser Tyr Ala Ser 485 <210> 224 <211> 452 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 224 Gly His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Lys Gln Leu Glu 1 5 10 15 Glu Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Ala Gly Gly Pro 20 25 30 Lys Lys Ile Arg Tyr Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 35 40 45 Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 50 55 60 Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 65 70 75 80 Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 85 90 95 Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 100 105 110 Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 115 120 125 Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 130 135 140 Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 145 150 155 160 Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 165 170 175 Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 180 185 190 Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 195 200 205 Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 210 215 220 Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 225 230 235 240 Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 245 250 255 Lys Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Ser Gly Ser Ala His 260 265 270 Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln Val Arg 275 280 285 Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Cys Gln Thr Glu Ala His Leu 290 295 300 Glu Ile Arg Glu Asp Gly Thr Val Gly Gly Ala Ala Asp Gln Ser Pro 305 310 315 320 Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys Pro Gly Val Ile Gln Ile 325 330 335 Leu Gly Val Lys Thr Ser Arg Phe Leu Cys Gln Arg Pro Asp Gly Ala 340 345 350 Leu Tyr Gly Ser Leu His Phe Asp Pro Glu Ala Cys Ser Phe Arg Glu 355 360 365 Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr Gln Ser Glu Ala His Gly 370 375 380 Leu Pro Leu His Leu Pro Gly Cys Lys Ser Pro His Arg Asp Pro Ala 385 390 395 400 Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu Pro Gly Leu Pro Pro Ala 405 410 415 Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro Gln Pro Pro Asp Val Gly 420 425 430 Ser Ser Asp Pro Leu Ser Met Val Tyr Pro Ser Gln Gly Arg Ser Pro 435 440 445 Ser Tyr Ala Ser 450 <210> 225 <211> 467 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 225 Gly His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Lys Gln Leu Glu 1 5 10 15 Glu Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Ala Gly Gly Pro 20 25 30 Lys Lys Ile Arg Tyr Ser Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala 35 40 45 Pro Ala Gly Gly Gly Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 50 55 60 Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 65 70 75 80 Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 85 90 95 Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 100 105 110 Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 115 120 125 Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 130 135 140 Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 145 150 155 160 Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 165 170 175 Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 180 185 190 Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 195 200 205 Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 210 215 220 Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 225 230 235 240 Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 245 250 255 Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 260 265 270 Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Ser Gly Ser Ala His Pro 275 280 285 Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln Val Arg Gln 290 295 300 Arg Tyr Leu Tyr Thr Asp Asp Ala Cys Gln Thr Glu Ala His Leu Glu 305 310 315 320 Ile Arg Glu Asp Gly Thr Val Gly Gly Ala Ala Asp Gln Ser Pro Glu 325 330 335 Ser Leu Leu Gln Leu Lys Ala Leu Lys Pro Gly Val Ile Gln Ile Leu 340 345 350 Gly Val Lys Thr Ser Arg Phe Leu Cys Gln Arg Pro Asp Gly Ala Leu 355 360 365 Tyr Gly Ser Leu His Phe Asp Pro Glu Ala Cys Ser Phe Arg Glu Leu 370 375 380 Leu Leu Glu Asp Gly Tyr Asn Val Tyr Gln Ser Glu Ala His Gly Leu 385 390 395 400 Pro Leu His Leu Pro Gly Cys Lys Ser Pro His Arg Asp Pro Ala Pro 405 410 415 Arg Gly Pro Ala Arg Phe Leu Pro Leu Pro Gly Leu Pro Pro Ala Pro 420 425 430 Pro Glu Pro Pro Gly Ile Leu Ala Pro Gln Pro Pro Asp Val Gly Ser 435 440 445 Ser Asp Pro Leu Ser Met Val Tyr Pro Ser Gln Gly Arg Ser Pro Ser 450 455 460 Tyr Ala Ser 465 <210> 226 <211> 474 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 226 Gly His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Lys Gln Leu Glu 1 5 10 15 Glu Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Ala Gly Gly Pro 20 25 30 Lys Lys Ile Arg Tyr Ser Pro Ala Pro Ala Pro Ala Glu Ala Ala Ala 35 40 45 Lys Glu Ala Ala Ala Lys Pro Ala Pro Ala Pro Ala Asp Lys Thr His 50 55 60 Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val 65 70 75 80 Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 85 90 95 Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 100 105 110 Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 115 120 125 Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 130 135 140 Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 145 150 155 160 Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 165 170 175 Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 180 185 190 Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 195 200 205 Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 210 215 220 Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 225 230 235 240 Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 245 250 255 Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 260 265 270 His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gly Gly 275 280 285 Gly Ser Gly Ser Ala His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln 290 295 300 Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Cys 305 310 315 320 Gln Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly 325 330 335 Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys 340 345 350 Pro Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys 355 360 365 Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu 370 375 380 Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr 385 390 395 400 Gln Ser Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Cys Lys Ser 405 410 415 Pro His Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu 420 425 430 Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro 435 440 445 Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Tyr Pro 450 455 460 Ser Gln Gly Arg Ser Pro Ser Tyr Ala Ser 465 470 <210> 227 <211> 471 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 227 Gly His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Lys Gln Leu Glu 1 5 10 15 Glu Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Ala Gly Gly Pro 20 25 30 Lys Lys Ile Arg Tyr Ser Ala Glu Ala Ala Ala Lys Glu Ala Ala Ala 35 40 45 Lys Glu Ala Ala Ala Lys Gly Gly Gly Asp Lys Thr His Thr Cys Pro 50 55 60 Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe 65 70 75 80 Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 85 90 95 Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 100 105 110 Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 115 120 125 Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 130 135 140 Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 145 150 155 160 Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 165 170 175 Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 180 185 190 Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 195 200 205 Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 210 215 220 Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 225 230 235 240 Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 245 250 255 Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 260 265 270 Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Ser Gly 275 280 285 Ser Ala His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly 290 295 300 Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Cys Gln Thr Glu 305 310 315 320 Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly Ala Ala Asp 325 330 335 Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys Pro Gly Val 340 345 350 Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys Gln Arg Pro 355 360 365 Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu Ala Cys Ser 370 375 380 Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr Gln Ser Glu 385 390 395 400 Ala His Gly Leu Pro Leu His Leu Pro Gly Cys Lys Ser Pro His Arg 405 410 415 Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu Pro Gly Leu 420 425 430 Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro Gln Pro Pro 435 440 445 Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Tyr Pro Ser Gln Gly 450 455 460 Arg Ser Pro Ser Tyr Ala Ser 465 470 <210> 228 <211> 496 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 228 Gly His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Lys Gln Leu Glu 1 5 10 15 Glu Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Ala Gly Gly Pro 20 25 30 Lys Lys Ile Arg Tyr Ser Ala Glu Ala Ala Ala Lys Glu Ala Ala Ala 35 40 45 Lys Glu Ala Ala Ala Lys Glu Ala Ala Lys Ala Leu Glu Ala Glu Ala 50 55 60 Ala Lys Glu Ala Ala Lys Glu Ala Ala Lys Glu Ala Ala Lys Ala Gly 65 70 75 80 Gly Gly Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala 85 90 95 Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 100 105 110 Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 115 120 125 Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 130 135 140 Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 145 150 155 160 Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 165 170 175 Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 180 185 190 Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 195 200 205 Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 210 215 220 Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 225 230 235 240 Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 245 250 255 Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 260 265 270 Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 275 280 285 Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 290 295 300 Leu Ser Pro Gly Gly Gly Gly Ser Gly Ser Ala His Pro Ile Pro Asp 305 310 315 320 Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu 325 330 335 Tyr Thr Asp Asp Ala Cys Gln Thr Glu Ala His Leu Glu Ile Arg Glu 340 345 350 Asp Gly Thr Val Gly Gly Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu 355 360 365 Gln Leu Lys Ala Leu Lys Pro Gly Val Ile Gln Ile Leu Gly Val Lys 370 375 380 Thr Ser Arg Phe Leu Cys Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser 385 390 395 400 Leu His Phe Asp Pro Glu Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu 405 410 415 Asp Gly Tyr Asn Val Tyr Gln Ser Glu Ala His Gly Leu Pro Leu His 420 425 430 Leu Pro Gly Cys Lys Ser Pro His Arg Asp Pro Ala Pro Arg Gly Pro 435 440 445 Ala Arg Phe Leu Pro Leu Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro 450 455 460 Pro Gly Ile Leu Ala Pro Gln Pro Pro Asp Val Gly Ser Ser Asp Pro 465 470 475 480 Leu Ser Met Val Tyr Pro Ser Gln Gly Arg Ser Pro Ser Tyr Ala Ser 485 490 495 <210> 229 <211> 472 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 229 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Lys Gln Leu Glu Lys 1 5 10 15 Arg Leu Val Arg Leu Phe Tyr Glu Trp Leu Ile Ala Gly Gly His Ser 20 25 30 Ser Gly Lys Pro Pro Pro Lys Gly Gly Gly Gly Gly Gly Gly Ser Gly 35 40 45 Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Asp Lys Thr His Thr Cys 50 55 60 Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu 65 70 75 80 Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 85 90 95 Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 100 105 110 Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 115 120 125 Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 130 135 140 Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 145 150 155 160 Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 165 170 175 Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 180 185 190 Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 195 200 205 Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 210 215 220 Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 225 230 235 240 Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 245 250 255 Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 260 265 270 His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Ser 275 280 285 Gly Ser Ala His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe Gly 290 295 300 Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Cys Gln Thr 305 310 315 320 Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly Ala Ala 325 330 335 Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys Pro Gly 340 345 350 Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys Gln Arg 355 360 365 Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu Ala Cys 370 375 380 Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr Gln Ser 385 390 395 400 Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Cys Lys Ser Pro His 405 410 415 Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu Pro Gly 420 425 430 Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro Gln Pro 435 440 445 Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Tyr Pro Ser Gln 450 455 460 Gly Arg Ser Pro Ser Tyr Ala Ser 465 470 <210> 230 <211> 460 <212> PRT <213> Artificial Sequence <220> <223> Fusion Protein <400> 230 His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Glu 1 5 10 15 Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 35 40 45 Ser Gly Gly Gly Gly Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 50 55 60 Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 65 70 75 80 Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 85 90 95 Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 100 105 110 Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 115 120 125 Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 130 135 140 Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 145 150 155 160 Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 165 170 175 Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 180 185 190 Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 195 200 205 Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 210 215 220 Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 225 230 235 240 Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 245 250 255 Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 260 265 270 Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Ser Asp Ser Ser Pro Leu 275 280 285 Leu Gln Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp 290 295 300 Ala Cys Gln Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val 305 310 315 320 Gly Gly Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala 325 330 335 Leu Lys Pro Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe 340 345 350 Leu Cys Gln Arg Pro Asp Gly Thr Leu Tyr Gly Ser Leu His Phe Asp 355 360 365 Pro Glu Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn 370 375 380 Val Tyr Gln Ser Glu Ala His Gly Leu Pro Leu His Leu Pro Cys Asn 385 390 395 400 Arg Ser Pro His Arg Asp Pro Ala Ser Arg Gly Pro Ala Arg Phe Leu 405 410 415 Pro Leu Pro Gly Leu Pro Pro Ala Leu Pro Glu Pro Pro Gly Ile Leu 420 425 430 Ala Pro Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ala Met Val 435 440 445 Gly Gly Ser Gln Ala Arg Ser Pro Ser Tyr Ala Ser 450 455 460 <210> 231 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> Linker <400> 231 Gly Gly Gly Ser Gly Ser Ala 1 5 <210> 232 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> Linker <400> 232 Gly Gly Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 1 5 10 15 Gly Ser Ala <210> 233 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> Linker <400> 233 Gly Gly Gly Ser Gly Gly Ser Gly Gly Ser Ala 1 5 10 <210> 234 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Linker <400> 234 Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala 1 5 10 15 <210> 235 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Linker <400> 235 Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 1 5 10 15 <210> 236 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Linker <400> 236 Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Gly Gly Gly 1 5 10 15 <210> 237 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> Linker <400> 237 Ala Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys 1 5 10 15 Gly Gly Gly <210> 238 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> Linker <400> 238 Gly Gly Lys Lys Gly Lys Lys Gly Lys Lys Gly Gly Ser Gly Lys Lys 1 5 10 15 Gly Ser Ala <210> 239 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Linker <400> 239 Gly Gly Lys Lys Lys Lys Gly Gly Lys Lys Lys Lys Gly Gly Lys Lys 1 5 10 15 Lys Lys Gly Ser Ala 20 <210> 240 <211> 22 <212> PRT <213> Artificial Sequence <220> <223> Linker <400> 240 Pro Ala Pro Ala Pro Ala Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys 1 5 10 15 Pro Ala Pro Ala Pro Ala 20 <210> 241 <211> 24 <212> PRT <213> Artificial Sequence <220> <223> Linker <400> 241 Gly Gly Lys Lys Lys Lys Lys Gly Gly Lys Lys Lys Lys Lys Gly Gly 1 5 10 15 Lys Lys Lys Lys Lys Gly Ser Ala 20 <210> 242 <211> 44 <212> PRT <213> Artificial Sequence <220> <223> Linker <400> 242 Ala Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys 1 5 10 15 Glu Ala Ala Lys Ala Leu Glu Ala Glu Ala Ala Lys Glu Ala Ala Lys 20 25 30 Glu Ala Ala Lys Glu Ala Ala Lys Ala Gly Gly Gly 35 40 <210> 243 <211> 4 <212> PRT <213> Artificial Sequence <220> <223> Linker <400> 243 Pro Ala Pro Ala 1 <210> 244 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> Linker <400> 244 Pro Ala Pro Ala Pro Ala 1 5 <210> 245 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Linker <400> 245 Pro Ala Pro Ala Pro Ala Gly Gly Gly 1 5 <210> 246 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Signal Sequence <400> 246 Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Leu Ser Leu Ala 1 5 10 15 Leu Val Thr Asn Ser 20 <210> 247 <211> 28 <212> PRT <213> Artificial Sequence <220> <223> His-Tag <400> 247 Asp Ile Gln Thr Gly Gly Ser His Ala His Gly His Gly His Ala His 1 5 10 15 Gly His Gly Gly Ser Gly Glu Asn Leu Tyr Phe Gln 20 25 <210> 248 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> His-Tag <400> 248 Met Gly His His His His His His His His Gly Gly Gly Glu Asn Leu 1 5 10 15 Tyr Phe Gln Gly 20 <210> 249 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> His-Tag <400> 249 Met Gly His His His His His His Gly Ser Leu Gln Asp Ser Glu Val 1 5 10 15 Asn Gln Glu Ala Lys Pro Glu Val Lys Pro Glu Val Lys Pro Glu Thr 20 25 30 His Ile Asn Leu Lys Val Ser Asp Gly Ser Ser Glu Ile Phe Phe Lys 35 40 45 Ile Lys Lys Thr Thr Pro Leu Arg Arg Leu Met Glu Ala Phe Ala Lys 50 55 60 Arg Gln Gly Lys Glu Met Asp Ser Leu Arg Phe Leu Tyr Asp Gly Ile 65 70 75 80 Arg Ile Gln Ala Asp Gln Ala Pro Glu Asp Leu Asp Met Glu Asp Asn 85 90 95 Asp Ile Ile Glu Ala His Arg Glu Gln Ile Gly Gly 100 105 <210> 250 <211> 209 <212> PRT <213> Homo sapiens <400> 250 Met Asp Ser Asp Glu Thr Gly Phe Glu His Ser Gly Leu Trp Val Ser 1 5 10 15 Val Leu Ala Gly Leu Leu Leu Gly Ala Cys Gln Ala His Pro Ile Pro 20 25 30 Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln Val Arg Gln Arg Tyr 35 40 45 Leu Tyr Thr Asp Asp Ala Gln Gln Thr Glu Ala His Leu Glu Ile Arg 50 55 60 Glu Asp Gly Thr Val Gly Gly Ala Ala Asp Gln Ser Pro Glu Ser Leu 65 70 75 80 Leu Gln Leu Lys Ala Leu Lys Pro Gly Val Ile Gln Ile Leu Gly Val 85 90 95 Lys Thr Ser Arg Phe Leu Cys Gln Arg Pro Asp Gly Ala Leu Tyr Gly 100 105 110 Ser Leu His Phe Asp Pro Glu Ala Cys Ser Phe Arg Glu Leu Leu Leu 115 120 125 Glu Asp Gly Tyr Asn Val Tyr Gln Ser Glu Ala His Gly Leu Pro Leu 130 135 140 His Leu Pro Gly Asn Lys Ser Pro His Arg Asp Pro Ala Pro Arg Gly 145 150 155 160 Pro Ala Arg Phe Leu Pro Leu Pro Gly Leu Pro Pro Ala Pro Pro Glu 165 170 175 Pro Pro Gly Ile Leu Ala Pro Gln Pro Pro Asp Val Gly Ser Ser Asp 180 185 190 Pro Leu Ser Met Val Gly Pro Ser Gln Gly Arg Ser Pro Ser Tyr Ala 195 200 205 Ser <210> 251 <211> 181 <212> PRT <213> Homo sapiens <400> 251 His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln Val 1 5 10 15 Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Gln Gln Thr Glu Ala His 20 25 30 Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly Ala Ala Asp Gln Ser 35 40 45 Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys Pro Gly Val Ile Gln 50 55 60 Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys Gln Arg Pro Asp Gly 65 70 75 80 Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu Ala Cys Ser Phe Arg 85 90 95 Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr Gln Ser Glu Ala His 100 105 110 Gly Leu Pro Leu His Leu Pro Gly Asn Lys Ser Pro His Arg Asp Pro 115 120 125 Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu Pro Gly Leu Pro Pro 130 135 140 Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro Gln Pro Pro Asp Val 145 150 155 160 Gly Ser Ser Asp Pro Leu Ser Met Val Gly Pro Ser Gln Gly Arg Ser 165 170 175 Pro Ser Tyr Ala Ser 180 <210> 252 <211> 182 <212> PRT <213> Artificial Sequence <220> <223> G-FGF21 <400> 252 Gly His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln 1 5 10 15 Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Gln Gln Thr Glu Ala 20 25 30 His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly Ala Ala Asp Gln 35 40 45 Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys Pro Gly Val Ile 50 55 60 Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys Gln Arg Pro Asp 65 70 75 80 Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu Ala Cys Ser Phe 85 90 95 Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr Gln Ser Glu Ala 100 105 110 His Gly Leu Pro Leu His Leu Pro Gly Asn Lys Ser Pro His Arg Asp 115 120 125 Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu Pro Gly Leu Pro 130 135 140 Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro Gln Pro Pro Asp 145 150 155 160 Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly Pro Ser Gln Gly Arg 165 170 175 Ser Pro Ser Tyr Ala Ser 180 <210> 253 <211> 180 <212> PRT <213> Artificial Sequence <220> <223> FGF21 Variant <400> 253 His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln Val 1 5 10 15 Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Cys Gln Thr Glu Ala His 20 25 30 Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly Ala Ala Asp Gln Ser 35 40 45 Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys Pro Gly Val Ile Gln 50 55 60 Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys Gln Arg Pro Asp Gly 65 70 75 80 Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu Ala Cys Ser Phe Arg 85 90 95 Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr Gln Ser Glu Ala His 100 105 110 Gly Leu Pro Leu His Leu Pro Gly Cys Lys Ser Pro His Arg Asp Pro 115 120 125 Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu Pro Gly Leu Pro Pro 130 135 140 Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro Gln Pro Pro Asp Val 145 150 155 160 Gly Ser Ser Asp Pro Leu Ser Met Val Gly Ser Gln Gly Arg Ser Pro 165 170 175 Ser Tyr Ala Ser 180 <210> 254 <211> 181 <212> PRT <213> Artificial Sequence <220> <223> FGF21 Variant <400> 254 His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln Val 1 5 10 15 Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Cys Gln Thr Glu Ala His 20 25 30 Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly Ala Ala Asp Gln Ser 35 40 45 Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys Pro Gly Val Ile Gln 50 55 60 Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys Gln Arg Pro Asp Gly 65 70 75 80 Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu Ala Cys Ser Phe Arg 85 90 95 Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr Gln Ser Glu Ala His 100 105 110 Gly Leu Pro Leu His Leu Pro Gly Cys Lys Ser Pro His Arg Asp Pro 115 120 125 Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu Pro Gly Leu Pro Pro 130 135 140 Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro Gln Pro Pro Asp Val 145 150 155 160 Gly Ser Ser Asp Pro Leu Ser Met Val Tyr Pro Ser Gln Gly Arg Ser 165 170 175 Pro Ser Tyr Ala Ser 180 <210> 255 <211> 180 <212> PRT <213> Artificial Sequence <220> <223> FGF21 Variant <400> 255 His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln Val 1 5 10 15 Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Cys Gln Thr Glu Ala His 20 25 30 Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly Ala Ala Asp Gln Ser 35 40 45 Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys Pro Gly Val Ile Gln 50 55 60 Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys Gln Arg Pro Asp Gly 65 70 75 80 Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu Ala Cys Ser Phe Arg 85 90 95 Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr Gln Ser Glu Ala His 100 105 110 Gly Leu Pro Leu His Leu Cys Gly Asn Lys Ser Pro His Arg Asp Pro 115 120 125 Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu Pro Gly Leu Pro Pro 130 135 140 Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro Gln Pro Pro Asp Val 145 150 155 160 Gly Ser Ser Asp Pro Leu Ser Met Val Gly Ser Gln Gly Arg Ser Pro 165 170 175 Ser Tyr Ala Ser 180 <210> 256 <211> 181 <212> PRT <213> Artificial Sequence <220> <223> FGF21 Variant <400> 256 His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln Val 1 5 10 15 Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Cys Gln Thr Glu Ala His 20 25 30 Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly Ala Ala Asp Gln Ser 35 40 45 Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys Pro Gly Val Ile Gln 50 55 60 Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys Gln Arg Pro Asp Gly 65 70 75 80 Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu Ala Cys Ser Phe Arg 85 90 95 Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr Gln Ser Glu Ala His 100 105 110 Gly Leu Pro Leu His Leu Cys Gly Asn Lys Ser Pro His Arg Asp Pro 115 120 125 Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu Pro Gly Leu Pro Pro 130 135 140 Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro Gln Pro Pro Asp Val 145 150 155 160 Gly Ser Ser Asp Pro Leu Ser Met Val Tyr Pro Ser Gln Gly Arg Ser 165 170 175 Pro Ser Tyr Ala Ser 180 <210> 257 <211> 225 <212> PRT <213> Artificial Sequence <220> <223> IgG1Fc-LALA <400> 257 Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly 1 5 10 15 Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 20 25 30 Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 35 40 45 Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 50 55 60 His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 65 70 75 80 Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 85 90 95 Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 100 105 110 Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 115 120 125 Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 130 135 140 Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 145 150 155 160 Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 165 170 175 Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 180 185 190 Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 195 200 205 His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 210 215 220 Pro 225 <210> 258 <211> 228 <212> PRT <213> Artificial Sequence <220> <223> IgG4Fc <400> 258 Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe 1 5 10 15 Glu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 20 25 30 Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 35 40 45 Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val 50 55 60 Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser 65 70 75 80 Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 85 90 95 Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser 100 105 110 Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 115 120 125 Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln 130 135 140 Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 145 150 155 160 Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 165 170 175 Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu 180 185 190 Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser 195 200 205 Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 210 215 220 Leu Ser Leu Gly 225 <210> 259 <211> 226 <212> PRT <213> Artificial Sequence <220> <223> IgG1NNAS <400> 259 Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 1 5 10 15 Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 20 25 30 Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 35 40 45 Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 50 55 60 His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Asn Ala Ser 65 70 75 80 Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 85 90 95 Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 100 105 110 Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 115 120 125 Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 130 135 140 Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 145 150 155 160 Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 165 170 175 Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 180 185 190 Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 195 200 205 His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 210 215 220 Pro Gly 225 <210> 260 <211> 30 <212> PRT <213> Homo sapiens <400> 260 His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 1 5 10 15 Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Arg 20 25 30 <210> 261 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 261 His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Leu Glu Glu 1 5 10 15 Glu Arg Val Gln Leu Phe Ile Glu Trp Leu Lys Ala Thr Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 262 <211> 38 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 262 Gly His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Lys Gln Leu Glu 1 5 10 15 Glu Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Ala Gly Gly Pro 20 25 30 Lys Lys Ile Arg Tyr Ser 35 <210> 263 <211> 44 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 263 His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Ile Gln Leu Asp Glu 1 5 10 15 Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Leu Ala Thr Gly Pro Val 20 25 30 Ser Gly Ala Pro Pro Ser Lys Lys Lys Lys Lys Lys 35 40 <210> 264 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 264 His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Leu Glu Glu 1 5 10 15 Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Ala Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 265 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 265 His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Leu Glu Glu 1 5 10 15 Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Ala Thr Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 266 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 266 His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Leu Glu Glu 1 5 10 15 Glu Ala Val Gln Leu Phe Ile Glu Trp Leu Lys Ala Thr Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 267 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 267 His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Leu Glu Glu 1 5 10 15 Glu Ala Val Gln Glu Phe Ile Glu Trp Leu Lys Ala Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 268 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 268 His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Leu Glu Glu 1 5 10 15 Glu Arg Val Gln Glu Phe Ile Glu Trp Leu Lys Ala Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 269 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 269 His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Ile Gln Leu Glu Glu 1 5 10 15 Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Leu Ala Thr Gly Pro Val 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 270 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 270 His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Ile Gln Leu Glu Glu 1 5 10 15 Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Leu Ala Thr Gly Pro Glu 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 271 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 271 His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Ile Gln Leu Glu Glu 1 5 10 15 Glu Arg Val Gln Glu Phe Ile Glu Trp Leu Leu Ala Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 272 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 272 His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Ile Gln Leu Glu Glu 1 5 10 15 Glu Ala Val Gln Glu Phe Ile Glu Trp Leu Leu Ala Thr Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 273 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 273 His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Ile Leu Leu Asp Glu 1 5 10 15 Glu Ala Val Arg Glu Phe Ile Glu Trp Leu Leu Ala Thr Gly Pro Val 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 274 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 274 Tyr Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Lys Gln Leu Glu Lys 1 5 10 15 Arg Leu Ala His Leu Phe Ile Glu Trp Leu Ile Ala Gly Gly His Ser 20 25 30 Ser Gly Lys Pro Pro Pro Lys 35 <210> 275 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 275 Tyr Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Lys Gln Leu Glu Lys 1 5 10 15 Arg Leu Ala His Leu Phe Ile Glu Trp Leu Ile Lys Gly Gly His Ser 20 25 30 Ser Gly Lys Pro Pro Pro Lys 35 <210> 276 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 276 His Thr Glu Gly Thr Phe Thr Ser Asp Lys Ser Lys Gln Leu Glu Lys 1 5 10 15 Arg Leu Val Arg Leu Phe Ile Glu Trp Leu Ile Lys Gly Gly His Ser 20 25 30 Ser Gly Lys Pro Pro Pro Lys 35 <210> 277 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 277 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Lys Gln Leu Ala Lys 1 5 10 15 Arg Leu Val Arg Leu Phe Ile Glu Trp Leu Ile Lys Gly Gly His Ser 20 25 30 Ser Gly Lys Pro Pro Pro Lys 35 <210> 278 <211> 38 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 278 Gly His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Lys Gln Leu Glu 1 5 10 15 Glu Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Ala Gly Gly Pro 20 25 30 Lys Lys Ile Arg Tyr Ser 35 <210> 279 <211> 38 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 279 Gly His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Lys Gln Leu Glu 1 5 10 15 Glu Glu Arg Val Gln Leu Phe Ile Glu Trp Leu Lys Ala Gly Gly Pro 20 25 30 Lys Lys Ile Arg Tyr Ser 35 <210> 280 <211> 37 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 280 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Lys Gln Leu Glu Glu 1 5 10 15 Glu Arg Val Gln Leu Phe Ile Glu Trp Leu Lys Ala Gly Gly Pro Lys 20 25 30 Lys Ile Arg Tyr Ser 35 <210> 281 <211> 38 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 281 Gly His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Leu Glu 1 5 10 15 Glu Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Ala Gly Gly Pro 20 25 30 Lys Lys Ile Arg Tyr Ser 35 <210> 282 <211> 38 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 282 Gly His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Leu Glu 1 5 10 15 Glu Glu Arg Val Arg Leu Phe Ile Glu Trp Leu Lys Ala Gly Gly Pro 20 25 30 Lys Lys Ile Arg Tyr Ser 35 <210> 283 <211> 37 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 283 His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Leu Glu Glu 1 5 10 15 Glu Arg Val Arg Leu Phe Ile Glu Trp Leu Lys Ala Gly Gly Pro Lys 20 25 30 Lys Ile Arg Tyr Ser 35 <210> 284 <211> 38 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 284 Gly His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Leu Glu 1 5 10 15 Glu Glu Arg Val Gln Leu Phe Ile Glu Trp Leu Lys Ala Gly Gly Pro 20 25 30 Lys Lys Ile Arg Tyr Ser 35 <210> 285 <211> 37 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 285 His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Leu Glu Glu 1 5 10 15 Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Ala Gly Gly Pro Lys 20 25 30 Lys Ile Arg Tyr Ser 35 <210> 286 <211> 38 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 286 Gly His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Leu Glu 1 5 10 15 Glu Glu Ala Val Gln Leu Phe Ile Glu Trp Leu Lys Ala Gly Gly Pro 20 25 30 Lys Lys Ile Arg Tyr Ser 35 <210> 287 <211> 37 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 287 His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Leu Glu Glu 1 5 10 15 Glu Ala Val Gln Leu Phe Ile Glu Trp Leu Lys Ala Gly Gly Pro Lys 20 25 30 Lys Ile Arg Tyr Ser 35 <210> 288 <211> 37 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 288 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Lys Gln Leu Glu Glu 1 5 10 15 Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Ala Gly Gly Pro Lys 20 25 30 Lys Ile Arg Tyr Ser 35 <210> 289 <211> 37 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 289 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Lys Gln Leu Glu Glu 1 5 10 15 Glu Ala Val Gln Leu Phe Ile Glu Trp Leu Lys Ala Gly Gly Pro Lys 20 25 30 Lys Ile Arg Tyr Ser 35 <210> 290 <211> 38 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 290 Gly His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Lys Gln Leu Glu 1 5 10 15 Glu Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Ala Gly Gly Pro 20 25 30 Lys Lys Gln Arg Leu Ser 35 <210> 291 <211> 40 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 291 Gly His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Leu Glu 1 5 10 15 Glu Glu Ala Val Gln Leu Phe Ile Glu Trp Leu Lys Ala Gly Gly Pro 20 25 30 Ser Ser Gly Ala Pro Pro Pro Ser 35 40 <210> 292 <211> 40 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 292 Gly His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Leu Glu 1 5 10 15 Glu Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Ala Gly Gly Pro 20 25 30 Ser Ser Gly Ala Pro Pro Pro Ser 35 40 <210> 293 <211> 40 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 293 Gly His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Lys Gln Leu Glu 1 5 10 15 Glu Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Ala Gly Gly Pro 20 25 30 Ser Ser Gly Ala Pro Pro Pro Ser 35 40 <210> 294 <211> 40 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 294 Gly His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Leu Glu 1 5 10 15 Glu Glu Arg Val Gln Leu Phe Ile Glu Trp Leu Lys Ala Gly Gly Pro 20 25 30 Ser Ser Gly Ala Pro Pro Pro Ser 35 40 <210> 295 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 295 Tyr Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Gln Leu Leu Glu Lys 1 5 10 15 Arg Leu Ala His Leu Phe Ile Glu Trp Leu Ile Ala Gly Gly His Ser 20 25 30 Ser Gly Lys Pro Pro Pro Lys 35 <210> 296 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 296 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Lys Gln Leu Glu Lys 1 5 10 15 Arg Leu Val Phe Leu Phe Ile Glu Trp Leu Ile Ala Gly Gly His Ser 20 25 30 Ser Gly Lys Pro Pro Pro Lys 35 <210> 297 <211> 38 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 297 Gly His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Lys Gln Leu Glu 1 5 10 15 Glu Glu Ala Val Gln Leu Phe Ile Glu Trp Leu Lys Ala Gly Gly Pro 20 25 30 Lys Lys Ile Arg Tyr Ser 35 <210> 298 <211> 38 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 298 Gly His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Lys Gln Leu Glu 1 5 10 15 Glu Glu Arg Val Arg Leu Phe Ile Glu Trp Leu Lys Ala Gly Gly Pro 20 25 30 Lys Lys Ile Arg Tyr Ser 35 <210> 299 <211> 37 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 299 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Lys Gln Leu Glu Glu 1 5 10 15 Glu Arg Val Arg Leu Phe Ile Glu Trp Leu Lys Ala Gly Gly Pro Lys 20 25 30 Lys Ile Arg Tyr Ser 35 <210> 300 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 300 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Lys Gln Leu Glu Glu 1 5 10 15 Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Ala Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 301 <211> 32 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 301 Gly His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Lys Gln Leu Glu 1 5 10 15 Glu Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Ala Gly Gly Pro 20 25 30 <210> 302 <211> 40 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 302 Ala His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Ile Gln Leu Glu 1 5 10 15 Lys Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Leu Ala Gly Gly His 20 25 30 Pro Ser Gly Lys Pro Pro Pro Lys 35 40 <210> 303 <211> 40 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 303 Ala His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Ile Leu Leu Asp 1 5 10 15 Glu Glu Ala Val Gln Glu Phe Ile Glu Trp Leu Leu Ala Thr Gly Pro 20 25 30 Ser Ser Gly Ala Pro Pro Pro Ser 35 40 <210> 304 <211> 40 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 304 Ala His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Ile Leu Leu Asp 1 5 10 15 Glu Glu Ala Val Gln Glu Phe Ile Glu Trp Leu Leu Ala Thr Gly Pro 20 25 30 Val Ser Gly Ala Pro Pro Pro Ser 35 40 <210> 305 <211> 40 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 305 Ala His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Ile Leu Leu Asp 1 5 10 15 Glu Glu Ala Val Gln Leu Phe Ile Glu Trp Leu Leu Ala Thr Gly Pro 20 25 30 Ser Ser Gly Ala Pro Pro Pro Ser 35 40 <210> 306 <211> 40 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 306 Ala His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Ile Leu Leu Asp 1 5 10 15 Glu Glu Ala Val Gln Leu Phe Ile Glu Trp Leu Leu Ala Thr Gly Pro 20 25 30 Val Ser Gly Ala Pro Pro Pro Ser 35 40 <210> 307 <211> 40 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 307 Ala His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Ile Leu Leu Asp 1 5 10 15 Glu Glu Ala Val Arg Glu Phe Ile Glu Trp Leu Leu Ala Thr Gly Pro 20 25 30 Ser Ser Gly Ala Pro Pro Pro Ser 35 40 <210> 308 <211> 40 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 308 Ala His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Ile Leu Leu Asp 1 5 10 15 Glu Glu Ala Val Arg Glu Phe Ile Glu Trp Leu Leu Ala Thr Gly Pro 20 25 30 Val Ser Gly Ala Pro Pro Pro Ser 35 40 <210> 309 <211> 40 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 309 Ala His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Ile Leu Leu Glu 1 5 10 15 Glu Glu Ala Val Gln Leu Phe Ile Glu Trp Leu Leu Ala Thr Gly Pro 20 25 30 Val Ser Gly Ala Pro Pro Pro Ser 35 40 <210> 310 <211> 40 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 310 Ala His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Ile Leu Leu Glu 1 5 10 15 Glu Glu Ala Val Arg Glu Phe Ile Glu Trp Leu Leu Ala Thr Gly Pro 20 25 30 Ser Ser Gly Ala Pro Pro Pro Ser 35 40 <210> 311 <211> 40 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 311 Ala His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Ile Leu Leu Glu 1 5 10 15 Glu Glu Ala Val Arg Glu Phe Ile Glu Trp Leu Leu Ala Thr Gly Pro 20 25 30 Val Ser Gly Ala Pro Pro Pro Ser 35 40 <210> 312 <211> 40 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 312 Ala His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Ile Leu Leu Glu 1 5 10 15 Glu Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Leu Ala Thr Gly Pro 20 25 30 Val Ser Gly Ala Pro Pro Pro Ser 35 40 <210> 313 <211> 40 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 313 Ala His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Ile Gln Leu Asp 1 5 10 15 Glu Glu Ala Val Gln Glu Phe Ile Glu Trp Leu Leu Ala Thr Gly Pro 20 25 30 Ser Ser Gly Ala Pro Pro Pro Ser 35 40 <210> 314 <211> 40 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 314 Ala His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Ile Gln Leu Asp 1 5 10 15 Glu Glu Ala Val Gln Glu Phe Ile Glu Trp Leu Leu Ala Thr Gly Pro 20 25 30 Val Ser Gly Ala Pro Pro Pro Ser 35 40 <210> 315 <211> 40 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 315 Ala His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Ile Gln Leu Asp 1 5 10 15 Glu Glu Ala Val Gln Leu Phe Ile Glu Trp Leu Leu Ala Thr Gly Pro 20 25 30 Ser Ser Gly Ala Pro Pro Pro Ser 35 40 <210> 316 <211> 40 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 316 Ala His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Ile Gln Leu Asp 1 5 10 15 Glu Glu Ala Val Gln Leu Phe Ile Glu Trp Leu Leu Ala Thr Gly Pro 20 25 30 Val Ser Gly Ala Pro Pro Pro Ser 35 40 <210> 317 <211> 40 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 317 Ala His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Ile Gln Leu Glu 1 5 10 15 Glu Glu Ala Val Gln Glu Phe Ile Glu Trp Leu Leu Ala Thr Gly Pro 20 25 30 Val Ser Gly Ala Pro Pro Pro Ser 35 40 <210> 318 <211> 40 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 318 Ala His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Ile Gln Leu Glu 1 5 10 15 Glu Glu Ala Val Gln Leu Phe Ile Glu Trp Leu Leu Ala Thr Gly Pro 20 25 30 Ser Ser Gly Ala Pro Pro Pro Ser 35 40 <210> 319 <211> 40 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 319 Ala His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Ile Gln Leu Glu 1 5 10 15 Glu Glu Ala Val Gln Leu Phe Ile Glu Trp Leu Leu Ala Thr Gly Pro 20 25 30 Val Ser Gly Ala Pro Pro Pro Ser 35 40 <210> 320 <211> 40 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 320 Ala His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Ile Gln Leu Glu 1 5 10 15 Glu Glu Ala Val Arg Glu Phe Ile Glu Trp Leu Leu Ala Thr Gly Pro 20 25 30 Val Ser Gly Ala Pro Pro Pro Ser 35 40 <210> 321 <211> 40 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 321 Ala His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Ile Gln Leu Glu 1 5 10 15 Glu Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Leu Ala Thr Gly Pro 20 25 30 Ser Ser Gly Ala Pro Pro Pro Ser 35 40 <210> 322 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 322 Phe Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Lys Gln Leu Glu Lys 1 5 10 15 Arg Leu Val Arg Leu Phe Ile Glu Trp Leu Ile Ala Gly Gly His Ser 20 25 30 Ser Gly Lys Pro Pro Pro Lys 35 <210> 323 <211> 40 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 323 Gly His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Ile Gln Leu Glu 1 5 10 15 Glu Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Leu Ala Gly Gly His 20 25 30 Pro Ser Gly Lys Pro Pro Pro Lys 35 40 <210> 324 <211> 38 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 324 Gly His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Lys Gln Leu Glu 1 5 10 15 Glu Glu Ala Glu Arg Leu Phe Ile Glu Trp Leu Lys Ala Gly Gly Pro 20 25 30 Lys Lys Ile Arg Tyr Ser 35 <210> 325 <211> 38 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 325 Gly His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Lys Gln Leu Glu 1 5 10 15 Glu Glu Ala Gly Arg Leu Phe Ile Glu Trp Leu Lys Ala Gly Gly Pro 20 25 30 Lys Lys Ile Arg Tyr Ser 35 <210> 326 <211> 38 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 326 Gly His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Lys Gln Leu Glu 1 5 10 15 Glu Glu Ala His Arg Leu Phe Ile Glu Trp Leu Lys Ala Gly Gly Pro 20 25 30 Lys Lys Ile Arg Tyr Ser 35 <210> 327 <211> 38 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 327 Gly His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Lys Gln Leu Glu 1 5 10 15 Glu Glu Ala Lys Arg Leu Phe Ile Glu Trp Leu Lys Ala Gly Gly Pro 20 25 30 Lys Lys Ile Arg Tyr Ser 35 <210> 328 <211> 38 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 328 Gly His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Lys Gln Leu Glu 1 5 10 15 Glu Glu Ala Gln Arg Leu Phe Ile Glu Trp Leu Lys Ala Gly Gly Pro 20 25 30 Lys Lys Ile Arg Tyr Ser 35 <210> 329 <211> 38 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 329 Gly His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Lys Gln Leu Glu 1 5 10 15 Glu Glu Ala Ser Arg Leu Phe Ile Glu Trp Leu Lys Ala Gly Gly Pro 20 25 30 Lys Lys Ile Arg Tyr Ser 35 <210> 330 <211> 38 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 330 Gly His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Lys Gln Leu Glu 1 5 10 15 Glu Glu Ala Thr Arg Leu Phe Ile Glu Trp Leu Lys Ala Gly Gly Pro 20 25 30 Lys Lys Ile Arg Tyr Ser 35 <210> 331 <211> 30 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 331 Gly His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Lys Gln Leu Glu 1 5 10 15 Glu Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Ala Gly 20 25 30 <210> 332 <211> 31 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 332 Gly His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Lys Gln Leu Glu 1 5 10 15 Glu Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Ala Gly Gly 20 25 30 <210> 333 <211> 40 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 333 Gly His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Lys Gln Leu Glu 1 5 10 15 Glu Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Ala Gly Gly His 20 25 30 Pro Ser Gly Lys Pro Pro Pro Lys 35 40 <210> 334 <211> 40 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 334 Gly His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Gln Leu Leu Glu 1 5 10 15 Lys Arg Leu Val His Leu Phe Ile Glu Trp Leu Ile Ala Gly Gly His 20 25 30 Ser Ser Gly Lys Leu Pro Pro Lys 35 40 <210> 335 <211> 40 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 335 Gly His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Ile Gln Leu Asp 1 5 10 15 Glu Glu Ala Val Gln Glu Phe Ile Glu Trp Leu Leu Ala Thr Gly Pro 20 25 30 Val Ser Gly Ala Pro Pro Pro Ser 35 40 <210> 336 <211> 40 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 336 Gly His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Ile Gln Leu Asp 1 5 10 15 Glu Glu Ala Val Gln Leu Phe Ile Glu Trp Leu Leu Ala Thr Gly Pro 20 25 30 Val Ser Gly Ala Pro Pro Pro Ser 35 40 <210> 337 <211> 40 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 337 Gly His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Ile Gln Leu Asp 1 5 10 15 Glu Glu Ala Val Arg Glu Phe Ile Glu Trp Leu Leu Ala Thr Gly Pro 20 25 30 Ser Ser Gly Ala Pro Pro Pro Ser 35 40 <210> 338 <211> 40 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 338 Gly His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Ile Gln Leu Glu 1 5 10 15 Glu Glu Ala Val Gln Leu Phe Ile Glu Trp Leu Leu Ala Thr Gly Pro 20 25 30 Ser Ser Gly Ala Pro Pro Pro Ser 35 40 <210> 339 <211> 40 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 339 Gly His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Ile Gln Leu Glu 1 5 10 15 Glu Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Leu Ala Gly Gly Pro 20 25 30 Ser Lys Gly Lys Pro Pro Pro Lys 35 40 <210> 340 <211> 40 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 340 Gly His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Ile Gln Leu Glu 1 5 10 15 Glu Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Leu Ala Gly Gly Pro 20 25 30 Ser Ser Gly Ala Pro Pro Pro Ser 35 40 <210> 341 <211> 40 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 341 Gly His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Ile Gln Leu Glu 1 5 10 15 Glu Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Leu Ala Gly Gly Pro 20 25 30 Ser Ser Gly Lys Pro Lys Pro Lys 35 40 <210> 342 <211> 40 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 342 Gly His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Ile Gln Leu Glu 1 5 10 15 Glu Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Leu Ala Gly Gly Pro 20 25 30 Ser Ser Gly Lys Pro Pro Pro Lys 35 40 <210> 343 <211> 40 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 343 Gly His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Ile Gln Leu Glu 1 5 10 15 Glu Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Leu Ala Lys Gly Lys 20 25 30 Ser Lys Gly Lys Pro Lys Pro Lys 35 40 <210> 344 <211> 40 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 344 Gly His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Ile Gln Leu Glu 1 5 10 15 Glu Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Leu Ala Thr Gly Pro 20 25 30 Ser Ser Gly Ala Pro Pro Pro Ser 35 40 <210> 345 <211> 40 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 345 Gly His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu 1 5 10 15 Glu Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro 20 25 30 Ser Ser Gly Ala Pro Pro Pro Ser 35 40 <210> 346 <211> 40 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 346 Gly Tyr Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Gln Leu Leu Glu 1 5 10 15 Glu Arg Leu Val His Leu Phe Ile Glu Trp Leu Ile Ala Gly Gly His 20 25 30 Ser Ser Ile Lys Pro Pro Pro Lys 35 40 <210> 347 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 347 His Ala Gln Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Leu Glu Ser 1 5 10 15 Arg Arg Ala Gln Glu Phe Ile Glu Trp Leu Leu Ala Thr Gly Pro Glu 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 348 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 348 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Ile Leu Leu Ala Lys 1 5 10 15 Arg Leu Val Arg Leu Phe Ile Glu Trp Leu Ile Ala Gly Gly His Ser 20 25 30 Ser Gly Lys Pro Pro Pro Lys 35 <210> 349 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 349 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Lys Leu Leu Glu Lys 1 5 10 15 Arg Ala Ala His Leu Phe Ile Glu Trp Leu Ile Ala Gly Gly His Ser 20 25 30 Lys Gly Lys Pro Pro Pro Lys 35 <210> 350 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 350 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Lys Leu Leu Glu Lys 1 5 10 15 Arg Ala Ala His Leu Phe Ile Glu Trp Leu Ile Ala Gly Gly His Ser 20 25 30 Ser Ile Lys Pro Pro Pro Lys 35 <210> 351 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 351 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Lys Leu Leu Glu Lys 1 5 10 15 Arg Leu Ala His Leu Phe Ile Glu Trp Leu Ile Ala Gly Gly His Ser 20 25 30 Lys Gly Lys Pro Pro Pro Lys 35 <210> 352 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 352 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Lys Leu Leu Glu Lys 1 5 10 15 Arg Leu Ala His Leu Phe Ile Glu Trp Leu Ile Lys Gly Gly His Lys 20 25 30 Ser Gly Lys Pro Pro Pro Lys 35 <210> 353 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 353 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Lys Leu Leu Glu Lys 1 5 10 15 Arg Leu Ala His Leu Phe Ile Glu Trp Leu Ile Lys Gly Gly His Ser 20 25 30 Lys Gly Lys Pro Pro Pro Lys 35 <210> 354 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 354 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Lys Leu Leu Glu Lys 1 5 10 15 Arg Leu Ala His Leu Phe Ile Glu Trp Leu Ile Lys Gly Gly His Ser 20 25 30 Ser Ile Lys Pro Pro Pro Lys 35 <210> 355 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 355 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Lys Leu Leu Glu Lys 1 5 10 15 Arg Leu Ala His Leu Phe Ile Glu Trp Leu Leu Ala Gly Gly His Ser 20 25 30 Lys Gly Lys Pro Pro Pro Lys 35 <210> 356 <211> 37 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 356 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Lys Gln Leu Ala Glu 1 5 10 15 Glu Ala Val Gln Leu Phe Ile Glu Trp Leu Leu Ala Gly Gly Pro Lys 20 25 30 Lys Ile Arg Tyr Ser 35 <210> 357 <211> 37 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 357 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Lys Gln Leu Ala Glu 1 5 10 15 Glu Ala Val Gln Leu Phe Ile Glu Trp Leu Leu Ala Gly Gly Pro Ser 20 25 30 Lys Glu Ile Ile Ser 35 <210> 358 <211> 37 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 358 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Lys Gln Leu Ala Glu 1 5 10 15 Arg Ala Val Gln Leu Phe Ile Glu Trp Leu Leu Ala Gly Gly Pro Lys 20 25 30 Lys Ile Arg Tyr Ser 35 <210> 359 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 359 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Lys Gln Leu Ala Glu 1 5 10 15 Arg Leu Ala Lys Leu Phe Ile Glu Trp Leu Ile Ala Gly Gly His Ser 20 25 30 Ser Gly Lys Pro Pro Pro Lys 35 <210> 360 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 360 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Lys Gln Leu Ala Glu 1 5 10 15 Arg Leu Ala Arg Glu Phe Ile Glu Trp Leu Ile Ala Gly Gly His Ser 20 25 30 Ser Gly Lys Pro Pro Pro Lys 35 <210> 361 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 361 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Lys Gln Leu Ala Glu 1 5 10 15 Arg Leu Val Lys Leu Phe Ile Glu Trp Leu Ile Ala Gly Gly His Ser 20 25 30 Ser Gly Lys Pro Pro Pro Lys 35 <210> 362 <211> 37 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 362 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Lys Gln Leu Ala Glu 1 5 10 15 Arg Leu Val Gln Leu Phe Ile Glu Trp Leu Leu Ala Gly Gly Pro Lys 20 25 30 Lys Ile Arg Tyr Ser 35 <210> 363 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 363 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Lys Gln Leu Ala Glu 1 5 10 15 Arg Leu Val Arg Glu Phe Ile Glu Trp Leu Ile Ala Gly Gly His Ser 20 25 30 Ser Gly Lys Pro Pro Pro Lys 35 <210> 364 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 364 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Lys Gln Leu Ala Glu 1 5 10 15 Arg Leu Val Arg Leu Phe Ile Glu Trp Leu Ile Ala Gly Gly His Ser 20 25 30 Ser Gly Lys Pro Pro Pro Lys 35 <210> 365 <211> 37 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 365 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Lys Gln Leu Ala Lys 1 5 10 15 Glu Ala Val Gln Leu Phe Ile Glu Trp Leu Leu Ala Gly Gly Pro Lys 20 25 30 Lys Ile Arg Tyr Ser 35 <210> 366 <211> 37 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 366 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Lys Gln Leu Ala Lys 1 5 10 15 Glu Leu Val Gln Leu Phe Ile Glu Trp Leu Leu Ala Gly Gly Pro Lys 20 25 30 Lys Ile Arg Tyr Ser 35 <210> 367 <211> 37 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 367 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Lys Gln Leu Ala Lys 1 5 10 15 Arg Ala Val Gln Leu Phe Ile Glu Trp Leu Leu Ala Gly Gly Pro Lys 20 25 30 Lys Ile Arg Tyr Ser 35 <210> 368 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 368 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Lys Gln Leu Ala Lys 1 5 10 15 Arg Leu Ala His Leu Phe Ile Glu Trp Leu Ile Ala Gly Gly His Ser 20 25 30 Ser Gly Lys Pro Pro Pro Lys 35 <210> 369 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 369 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Lys Gln Leu Ala Lys 1 5 10 15 Arg Leu Ala Gln Glu Phe Ile Glu Trp Leu Ile Lys Gly Gly His Ser 20 25 30 Ser Gly Lys Pro Pro Pro Lys 35 <210> 370 <211> 37 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 370 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Lys Gln Leu Ala Lys 1 5 10 15 Arg Leu Val Gln Leu Phe Ile Glu Trp Leu Leu Ala Gly Gly Pro Lys 20 25 30 Lys Ile Arg Tyr Ser 35 <210> 371 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 371 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Lys Gln Leu Ala Lys 1 5 10 15 Arg Leu Val Arg Glu Phe Ile Glu Trp Leu Ile Glu Gly Gly His Ser 20 25 30 Ser Gly Lys Pro Pro Pro Lys 35 <210> 372 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 372 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Lys Gln Leu Ala Lys 1 5 10 15 Arg Leu Val Arg Glu Phe Ile Glu Trp Leu Ile Lys Gly Gly His Ser 20 25 30 Ser Gly Lys Pro Pro Pro Lys 35 <210> 373 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 373 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Lys Gln Leu Ala Lys 1 5 10 15 Arg Leu Val Arg His Phe Ile Glu Trp Leu Ile Lys Gly Gly His Ser 20 25 30 Ser Gly Lys Pro Pro Pro Lys 35 <210> 374 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 374 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Lys Gln Leu Ala Lys 1 5 10 15 Arg Leu Val Arg Leu Phe Ile Glu Trp Leu Ile Ala Gly Gly His Ser 20 25 30 Ser Gly Lys Pro Pro Pro Lys 35 <210> 375 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 375 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Lys Gln Leu Ala Lys 1 5 10 15 Arg Leu Val Arg Leu Phe Ile Glu Trp Leu Ile Lys Gly Gly His Ser 20 25 30 Ser Gly Lys Pro Pro Pro Ser 35 <210> 376 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 376 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Lys Gln Leu Ala Lys 1 5 10 15 Arg Leu Val Arg Leu Phe Ile Glu Trp Leu Ile Lys Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 377 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 377 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Lys Gln Leu Ala Lys 1 5 10 15 Arg Leu Val Arg Leu Phe Val Gln Trp Leu Ile Lys Gly Gly His Ser 20 25 30 Ser Gly Lys Pro Pro Pro Lys 35 <210> 378 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 378 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Lys Gln Leu Asp Glu 1 5 10 15 Gln Arg Ala Lys Glu Phe Ile Glu Trp Leu Lys Ala Gly Gly His Pro 20 25 30 Ser Gly Lys Pro Pro Pro Lys 35 <210> 379 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 379 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Lys Gln Leu Glu Glu 1 5 10 15 Glu Leu Ala Arg Leu Phe Tyr Glu Trp Leu Ile Ala Gly Gly His Ser 20 25 30 Lys Gly Lys Pro Pro Pro Lys 35 <210> 380 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 380 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Lys Gln Leu Glu Glu 1 5 10 15 Glu Leu Val Arg Leu Phe Tyr Glu Trp Leu Ile Lys Gly Gly His Ser 20 25 30 Ser Ile Lys Pro Pro Pro Lys 35 <210> 381 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 381 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Lys Gln Leu Glu Glu 1 5 10 15 Glu Leu Val Arg Leu Phe Tyr Glu Trp Leu Ile Asn Gly Gly His Ser 20 25 30 Lys Gly Lys Pro Pro Pro Lys 35 <210> 382 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 382 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Lys Gln Leu Glu Glu 1 5 10 15 Glu Leu Val Arg Leu Phe Tyr Glu Trp Leu Ile Asn Gly Gly His Ser 20 25 30 Ser Ile Lys Pro Pro Pro Lys 35 <210> 383 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 383 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Lys Gln Leu Glu Glu 1 5 10 15 Glu Leu Val Arg Leu Phe Tyr Glu Trp Leu Leu Ala Gly Gly His Ser 20 25 30 Ser Ile Lys Pro Pro Pro Lys 35 <210> 384 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 384 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Lys Gln Leu Glu Glu 1 5 10 15 Arg Leu Ala Arg Leu Phe Tyr Glu Trp Leu Ile Ala Gly Gly His Ser 20 25 30 Lys Ile Lys Pro Pro Pro Lys 35 <210> 385 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 385 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Lys Gln Leu Glu Glu 1 5 10 15 Arg Leu Ala Arg Leu Phe Tyr Glu Trp Leu Ile Asn Gly Gly His Ser 20 25 30 Ser Ile Lys Pro Pro Pro Lys 35 <210> 386 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 386 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Lys Gln Leu Glu Glu 1 5 10 15 Arg Leu Ala Arg Leu Phe Tyr Glu Trp Leu Lys Ala Gly Gly His Ser 20 25 30 Lys Gly Lys Pro Pro Pro Lys 35 <210> 387 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 387 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Lys Gln Leu Glu Glu 1 5 10 15 Arg Leu Ala Arg Leu Phe Tyr Glu Trp Leu Lys Ala Gly Gly His Ser 20 25 30 Ser Ile Lys Pro Pro Pro Lys 35 <210> 388 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 388 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Lys Gln Leu Glu Lys 1 5 10 15 Glu Ala Val Arg Leu Phe Tyr Glu Trp Leu Lys Ala Gly Gly His Ser 20 25 30 Lys Gly Lys Pro Pro Pro Lys 35 <210> 389 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 389 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Lys Gln Leu Glu Lys 1 5 10 15 Glu Leu Val Arg Leu Phe Tyr Glu Trp Leu Ile Asn Gly Gly His Ser 20 25 30 Lys Ile Lys Pro Pro Pro Lys 35 <210> 390 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 390 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Lys Gln Leu Glu Lys 1 5 10 15 Glu Leu Val Arg Leu Phe Tyr Glu Trp Leu Ile Asn Gly Gly His Ser 20 25 30 Ser Ile Arg Pro Pro Pro Lys 35 <210> 391 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 391 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Lys Gln Leu Glu Lys 1 5 10 15 Glu Leu Val Arg Leu Phe Tyr Glu Trp Leu Ile Asn Gly Gly Pro Ser 20 25 30 Lys Gly Lys Pro Pro Pro Lys 35 <210> 392 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 392 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Lys Gln Leu Glu Lys 1 5 10 15 Glu Leu Val Arg Leu Phe Tyr Glu Trp Leu Ile Asn Gly Gly Pro Ser 20 25 30 Ser Ile Lys Pro Pro Pro Lys 35 <210> 393 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 393 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Lys Gln Leu Glu Lys 1 5 10 15 Glu Leu Val Arg Leu Phe Tyr Glu Trp Leu Lys Ala Gly Gly His Ser 20 25 30 Lys Ile Lys Pro Pro Pro Lys 35 <210> 394 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 394 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Lys Gln Leu Glu Lys 1 5 10 15 Glu Leu Val Arg Leu Phe Tyr Glu Trp Leu Lys Ala Gly Gly His Ser 20 25 30 Lys Gln Lys Pro Pro Pro Lys 35 <210> 395 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 395 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Lys Gln Leu Glu Lys 1 5 10 15 Glu Leu Val Arg Leu Phe Tyr Glu Trp Leu Lys Lys Gly Gly His Ser 20 25 30 Ser Ile Lys Pro Pro Pro Lys 35 <210> 396 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 396 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Lys Gln Leu Glu Lys 1 5 10 15 Glu Leu Val Arg Leu Phe Tyr Glu Trp Leu Lys Asn Gly Gly His Ser 20 25 30 Lys Gly Lys Pro Pro Pro Lys 35 <210> 397 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 397 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Lys Gln Leu Glu Lys 1 5 10 15 Glu Leu Val Arg Leu Phe Tyr Glu Trp Leu Lys Asn Gly Gly His Ser 20 25 30 Ser Ile Lys Pro Pro Pro Lys 35 <210> 398 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 398 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Lys Gln Leu Glu Lys 1 5 10 15 Glu Leu Val Arg Leu Phe Tyr Glu Trp Leu Leu Ala Gly Gly His Ser 20 25 30 Lys Ile Lys Pro Pro Pro Lys 35 <210> 399 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 399 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Lys Gln Leu Glu Lys 1 5 10 15 Arg Ala Val Arg Leu Phe Phe Glu Trp Leu Lys Ala Gly Gly His Ser 20 25 30 Ser Ile Lys Pro Pro Pro Lys 35 <210> 400 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 400 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Lys Gln Leu Glu Lys 1 5 10 15 Arg Ala Val Arg Leu Phe Tyr Glu Trp Leu Lys Ala Gly Gly His Ser 20 25 30 Lys Ile Lys Pro Pro Pro Lys 35 <210> 401 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 401 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Lys Gln Leu Glu Lys 1 5 10 15 Arg Leu Ala Arg Leu Phe Phe Glu Trp Leu Ile Ala Gly Gly His Ser 20 25 30 Lys Ile Lys Pro Pro Pro Lys 35 <210> 402 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 402 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Lys Gln Leu Glu Lys 1 5 10 15 Arg Leu Ala Arg Leu Phe Phe Glu Trp Leu Lys Ala Gly Gly His Ser 20 25 30 Lys Gly Lys Pro Pro Pro Lys 35 <210> 403 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 403 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Lys Gln Leu Glu Lys 1 5 10 15 Arg Leu Ala Arg Leu Phe Phe Glu Trp Leu Lys Ala Gly Gly His Ser 20 25 30 Ser Ile Lys Pro Pro Pro Lys 35 <210> 404 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 404 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Lys Gln Leu Glu Lys 1 5 10 15 Arg Leu Ala Arg Leu Phe Tyr Glu Trp Leu Ile Ala Gly Gly His Ser 20 25 30 Lys Ile Arg Pro Pro Pro Lys 35 <210> 405 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 405 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Lys Gln Leu Glu Lys 1 5 10 15 Arg Leu Ala Arg Leu Phe Tyr Glu Trp Leu Ile Ala Gly Gly Pro Ser 20 25 30 Lys Ile Lys Pro Pro Pro Lys 35 <210> 406 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 406 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Lys Gln Leu Glu Lys 1 5 10 15 Arg Leu Ala Arg Leu Phe Tyr Glu Trp Leu Lys Ala Gly Gly His Lys 20 25 30 Lys Gly Lys Pro Pro Pro Lys 35 <210> 407 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 407 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Lys Gln Leu Glu Lys 1 5 10 15 Arg Leu Ala Arg Leu Phe Tyr Glu Trp Leu Lys Ala Gly Gly His Ser 20 25 30 Lys Gly Lys Pro Pro Pro Lys 35 <210> 408 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 408 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Lys Gln Leu Glu Lys 1 5 10 15 Arg Leu Ala Arg Leu Phe Tyr Glu Trp Leu Lys Ala Gly Gly His Ser 20 25 30 Lys Ile Lys Pro Pro Pro Lys 35 <210> 409 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 409 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Lys Gln Leu Glu Lys 1 5 10 15 Arg Leu Ala Arg Leu Phe Tyr Glu Trp Leu Lys Ala Gly Gly His Ser 20 25 30 Ser Ile Lys Pro Pro Pro Lys 35 <210> 410 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 410 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Lys Gln Leu Glu Lys 1 5 10 15 Arg Leu Ala Arg Leu Phe Tyr Glu Trp Leu Lys Ala Gly Gly His Ser 20 25 30 Ser Ile Arg Pro Pro Pro Lys 35 <210> 411 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 411 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Lys Gln Leu Glu Lys 1 5 10 15 Arg Leu Ala Arg Leu Phe Tyr Glu Trp Leu Lys Ala Gly Gly Pro Ser 20 25 30 Lys Gly Lys Pro Pro Pro Lys 35 <210> 412 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 412 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Lys Gln Leu Glu Lys 1 5 10 15 Arg Leu Ala Arg Leu Phe Tyr Glu Trp Leu Lys Ala Gly Gly Pro Ser 20 25 30 Ser Ile Lys Pro Pro Pro Lys 35 <210> 413 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 413 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Lys Gln Leu Glu Lys 1 5 10 15 Arg Leu Ala Arg Leu Phe Tyr Glu Trp Leu Leu Ala Gly Gly His Ser 20 25 30 Lys Ile Lys Pro Pro Pro Lys 35 <210> 414 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 414 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Lys Gln Leu Glu Lys 1 5 10 15 Arg Leu Phe Arg Leu Phe Ile Glu Trp Leu Ile Ala Gly Gly His Ser 20 25 30 Ser Gly Lys Pro Pro Pro Lys 35 <210> 415 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 415 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Lys Gln Leu Glu Lys 1 5 10 15 Arg Leu Val Ile Leu Phe Ile Glu Trp Leu Ile Ala Gly Gly His Ser 20 25 30 Ser Gly Lys Pro Pro Pro Lys 35 <210> 416 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 416 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Lys Gln Leu Glu Lys 1 5 10 15 Arg Leu Val Arg Ile Phe Ile Glu Trp Leu Ile Ala Gly Gly His Ser 20 25 30 Ser Gly Lys Pro Pro Pro Lys 35 <210> 417 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 417 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Lys Gln Leu Glu Lys 1 5 10 15 Arg Leu Val Arg Leu Phe Phe Glu Trp Leu Ile Ala Gly Gly His Ser 20 25 30 Ser Gly Lys Pro Pro Pro Lys 35 <210> 418 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 418 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Lys Gln Leu Glu Lys 1 5 10 15 Arg Leu Val Arg Leu Phe Phe Glu Trp Leu Ile Lys Gly Gly His Ser 20 25 30 Lys Ile Lys Pro Pro Pro Lys 35 <210> 419 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 419 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Lys Gln Leu Glu Lys 1 5 10 15 Arg Leu Val Arg Leu Phe Phe Glu Trp Leu Ile Asn Gly Gly His Ser 20 25 30 Lys Ile Lys Pro Pro Pro Lys 35 <210> 420 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 420 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Lys Gln Leu Glu Lys 1 5 10 15 Arg Leu Val Arg Leu Phe Phe Glu Trp Leu Lys Lys Gly Gly His Ser 20 25 30 Lys Gly Lys Pro Pro Pro Lys 35 <210> 421 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 421 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Lys Gln Leu Glu Lys 1 5 10 15 Arg Leu Val Arg Leu Phe Phe Glu Trp Leu Lys Lys Gly Gly His Ser 20 25 30 Ser Ile Lys Pro Pro Pro Lys 35 <210> 422 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 422 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Lys Gln Leu Glu Lys 1 5 10 15 Arg Leu Val Arg Leu Phe Phe Glu Trp Leu Lys Asn Gly Gly His Ser 20 25 30 Lys Gly Lys Pro Pro Pro Lys 35 <210> 423 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 423 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Lys Gln Leu Glu Lys 1 5 10 15 Arg Leu Val Arg Leu Phe Phe Glu Trp Leu Lys Asn Gly Gly His Ser 20 25 30 Ser Ile Lys Pro Pro Pro Lys 35 <210> 424 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 424 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Lys Gln Leu Glu Lys 1 5 10 15 Arg Leu Val Arg Leu Phe His Glu Trp Leu Ile Ala Gly Gly His Ser 20 25 30 Ser Gly Lys Pro Pro Pro Lys 35 <210> 425 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 425 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Lys Gln Leu Glu Lys 1 5 10 15 Arg Leu Val Arg Leu Phe Ile Glu Leu Leu Ile Ala Gly Gly His Ser 20 25 30 Ser Gly Lys Pro Pro Pro Lys 35 <210> 426 <211> 38 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 426 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Lys Gln Leu Glu Lys 1 5 10 15 Arg Leu Val Arg Leu Phe Ile Glu Trp Leu Ile Ala Val Gly His Ser 20 25 30 Gly Lys Pro Pro Pro Lys 35 <210> 427 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 427 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Lys Gln Leu Glu Lys 1 5 10 15 Arg Leu Val Arg Leu Phe Ile Leu Trp Leu Ile Ala Gly Gly His Ser 20 25 30 Ser Gly Lys Pro Pro Pro Lys 35 <210> 428 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 428 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Lys Gln Leu Glu Lys 1 5 10 15 Arg Leu Val Arg Leu Phe Ile Tyr Trp Leu Ile Ala Gly Gly His Ser 20 25 30 Ser Gly Lys Pro Pro Pro Lys 35 <210> 429 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 429 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Lys Gln Leu Glu Lys 1 5 10 15 Arg Leu Val Arg Leu Phe Tyr Glu Trp Leu Ile Ala Gly Gly His Ser 20 25 30 Ser Gly Lys Pro Pro Pro Lys 35 <210> 430 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 430 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Lys Gln Leu Glu Lys 1 5 10 15 Arg Leu Val Arg Leu Phe Tyr Glu Trp Leu Ile Lys Gly Gly His Ser 20 25 30 Lys Ile Lys Pro Pro Pro Lys 35 <210> 431 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 431 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Lys Gln Leu Glu Lys 1 5 10 15 Arg Leu Val Arg Leu Phe Tyr Glu Trp Leu Ile Lys Gly Gly His Ser 20 25 30 Lys Ile Arg Pro Pro Pro Lys 35 <210> 432 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 432 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Lys Gln Leu Glu Lys 1 5 10 15 Arg Leu Val Arg Leu Phe Tyr Glu Trp Leu Ile Asn Gly Gly His Lys 20 25 30 Lys Ile Lys Pro Pro Pro Lys 35 <210> 433 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 433 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Lys Gln Leu Glu Lys 1 5 10 15 Arg Leu Val Arg Leu Phe Tyr Glu Trp Leu Ile Asn Gly Gly His Ser 20 25 30 Lys Ile Lys Pro Pro Pro Lys 35 <210> 434 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 434 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Lys Gln Leu Glu Lys 1 5 10 15 Arg Leu Val Arg Leu Phe Tyr Glu Trp Leu Ile Asn Gly Gly His Ser 20 25 30 Lys Ile Arg Pro Pro Pro Lys 35 <210> 435 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 435 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Lys Gln Leu Glu Lys 1 5 10 15 Arg Leu Val Arg Leu Phe Tyr Glu Trp Leu Lys Ala Gly Gly His Ser 20 25 30 Lys Ile Lys Tyr Pro Pro Lys 35 <210> 436 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 436 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Lys Gln Leu Glu Lys 1 5 10 15 Arg Leu Val Arg Leu Leu Ile Glu Trp Leu Ile Ala Gly Gly His Ser 20 25 30 Ser Gly Lys Pro Pro Pro Lys 35 <210> 437 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 437 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Lys Gln Leu Glu Lys 1 5 10 15 Arg Arg Val Arg Leu Phe Phe Glu Trp Leu Lys Ala Gly Gly His Ser 20 25 30 Ser Ile Lys Pro Pro Pro Lys 35 <210> 438 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 438 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Lys Gln Leu Glu Lys 1 5 10 15 Arg Arg Val Arg Leu Phe Tyr Glu Trp Leu Lys Ala Gly Gly His Ser 20 25 30 Lys Ile Lys Pro Pro Pro Lys 35 <210> 439 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 439 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Gln Leu Leu Glu Glu 1 5 10 15 Arg Leu Ala His Leu Phe Ile Glu Trp Leu Ile Ala Gly Gly His Ser 20 25 30 Lys Gln Lys Pro Pro Pro Lys 35 <210> 440 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 440 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Gln Leu Leu Glu Glu 1 5 10 15 Arg Leu Ala His Leu Phe Ile Glu Trp Leu Ile Ala Gly Gly His Ser 20 25 30 Ser Gly Arg Pro Pro Pro Lys 35 <210> 441 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 441 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Gln Leu Leu Glu Glu 1 5 10 15 Arg Leu Ala His Leu Phe Ile Glu Trp Leu Ile Lys Gly Gly His Ser 20 25 30 Ser Ile Lys Pro Pro Pro Lys 35 <210> 442 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 442 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Gln Leu Leu Glu Glu 1 5 10 15 Arg Leu Val His Leu Phe Ile Glu Trp Leu Ile Ala Gly Gly His Ser 20 25 30 Ser Gly Lys Leu Pro Pro Lys 35 <210> 443 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 443 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Gln Leu Leu Glu Lys 1 5 10 15 Glu Ala Ala His Leu Phe Ile Glu Trp Leu Ile Ala Gly Gly His Ser 20 25 30 Lys Gly Lys Pro Pro Pro Lys 35 <210> 444 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 444 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Gln Leu Leu Glu Lys 1 5 10 15 Glu Ala Ala His Leu Phe Ile Glu Trp Leu Ile Ala Gly Gly His Ser 20 25 30 Ser Ile Lys Pro Pro Pro Lys 35 <210> 445 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 445 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Gln Leu Leu Glu Lys 1 5 10 15 Glu Leu Ala His Leu Phe Ile Glu Trp Leu Ile Ala Gly Gly His Ser 20 25 30 Lys Gly Arg Pro Pro Pro Lys 35 <210> 446 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 446 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Gln Leu Leu Glu Lys 1 5 10 15 Glu Leu Ala His Leu Phe Ile Glu Trp Leu Ile Ala Gly Gly His Ser 20 25 30 Lys Gln Lys Pro Pro Pro Lys 35 <210> 447 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 447 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Gln Leu Leu Glu Lys 1 5 10 15 Glu Leu Ala His Leu Phe Ile Glu Trp Leu Ile Ala Gly Gly His Ser 20 25 30 Ser Ile Lys Pro Pro Pro Lys 35 <210> 448 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 448 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Gln Leu Leu Glu Lys 1 5 10 15 Glu Leu Ala His Leu Phe Ile Glu Trp Leu Ile Ala Gly Gly His Ser 20 25 30 Ser Ile Arg Pro Pro Pro Lys 35 <210> 449 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 449 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Gln Leu Leu Glu Lys 1 5 10 15 Glu Leu Ala His Leu Phe Ile Glu Trp Leu Leu Ala Gly Gly His Ser 20 25 30 Lys Gly Lys Pro Pro Pro Lys 35 <210> 450 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 450 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Gln Leu Leu Glu Lys 1 5 10 15 Arg Ala Ala His Leu Phe Ile Glu Trp Leu Ile Ala Gly Gly His Lys 20 25 30 Lys Gly Lys Pro Pro Pro Lys 35 <210> 451 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 451 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Gln Leu Leu Glu Lys 1 5 10 15 Arg Ala Ala His Leu Phe Ile Glu Trp Leu Ile Ala Gly Gly His Ser 20 25 30 Lys Gly Arg Pro Pro Pro Lys 35 <210> 452 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 452 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Gln Leu Leu Glu Lys 1 5 10 15 Arg Ala Ala His Leu Phe Ile Glu Trp Leu Ile Ala Gly Gly His Ser 20 25 30 Ser Gly Lys Leu Ser Pro Lys 35 <210> 453 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 453 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Gln Leu Leu Glu Lys 1 5 10 15 Arg Ala Ala His Leu Phe Ile Glu Trp Leu Ile Ala Gly Gly His Ser 20 25 30 Ser Gly Arg Tyr Pro Pro Lys 35 <210> 454 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 454 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Gln Leu Leu Glu Lys 1 5 10 15 Arg Ala Ala His Leu Phe Ile Glu Trp Leu Ile Ala Gly Gly Pro Ser 20 25 30 Lys Gly Lys Pro Pro Pro Lys 35 <210> 455 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 455 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Gln Leu Leu Glu Lys 1 5 10 15 Arg Ala Ala His Leu Phe Ile Glu Trp Leu Ile Ala Gly Gly Pro Ser 20 25 30 Ser Gly Lys Leu Pro Pro Lys 35 <210> 456 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 456 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Gln Leu Leu Glu Lys 1 5 10 15 Arg Ala Ala His Leu Phe Ile Glu Trp Leu Ile Lys Gly Gly His Ser 20 25 30 Lys Gly Lys Pro Pro Pro Lys 35 <210> 457 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 457 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Gln Leu Leu Glu Lys 1 5 10 15 Arg Ala Ala His Leu Phe Ile Glu Trp Leu Ile Lys Gly Gly His Ser 20 25 30 Ser Ile Lys Pro Pro Pro Lys 35 <210> 458 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 458 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Gln Leu Leu Glu Lys 1 5 10 15 Arg Ala Ala His Leu Phe Ile Glu Trp Leu Leu Ala Gly Gly His Ser 20 25 30 Ser Ile Lys Pro Pro Pro Lys 35 <210> 459 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 459 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Gln Leu Leu Glu Lys 1 5 10 15 Arg Leu Ala His Leu Phe Ile Glu Trp Leu Ile Ala Gly Gly His Lys 20 25 30 Lys Gly Lys Tyr Pro Pro Lys 35 <210> 460 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 460 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Gln Leu Leu Glu Lys 1 5 10 15 Arg Leu Ala His Leu Phe Ile Glu Trp Leu Ile Ala Gly Gly His Lys 20 25 30 Ser Gly Lys Tyr Ser Pro Lys 35 <210> 461 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 461 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Gln Leu Leu Glu Lys 1 5 10 15 Arg Leu Ala His Leu Phe Ile Glu Trp Leu Ile Ala Gly Gly His Ser 20 25 30 Lys Gly Arg Leu Pro Pro Lys 35 <210> 462 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 462 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Gln Leu Leu Glu Lys 1 5 10 15 Arg Leu Ala His Leu Phe Ile Glu Trp Leu Ile Ala Gly Gly His Ser 20 25 30 Lys Ile Lys Tyr Pro Pro Lys 35 <210> 463 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 463 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Gln Leu Leu Glu Lys 1 5 10 15 Arg Leu Ala His Leu Phe Ile Glu Trp Leu Ile Ala Gly Gly His Ser 20 25 30 Ser Gly Arg Leu Ser Pro Lys 35 <210> 464 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 464 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Gln Leu Leu Glu Lys 1 5 10 15 Arg Leu Ala His Leu Phe Ile Glu Trp Leu Ile Ala Gly Gly His Ser 20 25 30 Ser Gly Arg Tyr Ser Pro Lys 35 <210> 465 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 465 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Gln Leu Leu Glu Lys 1 5 10 15 Arg Leu Ala His Leu Phe Ile Glu Trp Leu Ile Ala Gly Gly His Ser 20 25 30 Ser Ile Lys Pro Pro Pro Lys 35 <210> 466 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 466 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Gln Leu Leu Glu Lys 1 5 10 15 Arg Leu Ala His Leu Phe Ile Glu Trp Leu Ile Ala Gly Gly Pro Ser 20 25 30 Lys Gly Lys Pro Pro Pro Lys 35 <210> 467 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 467 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Gln Leu Leu Glu Lys 1 5 10 15 Arg Leu Ala His Leu Phe Ile Glu Trp Leu Ile Ala Gly Gly Pro Ser 20 25 30 Lys Gly Arg Pro Pro Pro Lys 35 <210> 468 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 468 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Gln Leu Leu Glu Lys 1 5 10 15 Arg Leu Ala His Leu Phe Ile Glu Trp Leu Ile Ala Gly Gly Pro Ser 20 25 30 Ser Gly Lys Tyr Ser Pro Lys 35 <210> 469 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 469 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Gln Leu Leu Glu Lys 1 5 10 15 Arg Leu Ala His Leu Phe Ile Glu Trp Leu Ile Ala Gly Gly Pro Ser 20 25 30 Ser Gly Arg Tyr Pro Pro Lys 35 <210> 470 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 470 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Gln Leu Leu Glu Lys 1 5 10 15 Arg Leu Ala His Leu Phe Ile Glu Trp Leu Ile Lys Gly Gly His Ser 20 25 30 Lys Gly Lys Pro Pro Pro Lys 35 <210> 471 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 471 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Gln Leu Leu Glu Lys 1 5 10 15 Arg Leu Ala His Leu Phe Ile Glu Trp Leu Ile Lys Gly Gly His Ser 20 25 30 Lys Gly Lys Tyr Pro Pro Lys 35 <210> 472 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 472 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Gln Leu Leu Glu Lys 1 5 10 15 Arg Leu Ala His Leu Phe Ile Glu Trp Leu Ile Lys Gly Gly His Ser 20 25 30 Lys Gly Arg Pro Pro Pro Lys 35 <210> 473 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 473 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Gln Leu Leu Glu Lys 1 5 10 15 Arg Leu Ala His Leu Phe Ile Glu Trp Leu Ile Lys Gly Gly His Ser 20 25 30 Lys Gln Lys Pro Pro Pro Lys 35 <210> 474 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 474 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Gln Leu Leu Glu Lys 1 5 10 15 Arg Leu Ala His Leu Phe Ile Glu Trp Leu Ile Lys Gly Gly His Ser 20 25 30 Ser Gly Lys Pro Pro Pro Lys 35 <210> 475 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 475 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Gln Leu Leu Glu Lys 1 5 10 15 Arg Leu Ala His Leu Phe Ile Glu Trp Leu Ile Lys Gly Gly His Ser 20 25 30 Ser Gly Arg Pro Pro Pro Lys 35 <210> 476 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 476 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Gln Leu Leu Glu Lys 1 5 10 15 Arg Leu Ala His Leu Phe Ile Glu Trp Leu Ile Lys Gly Gly His Ser 20 25 30 Ser Ile Arg Pro Pro Pro Lys 35 <210> 477 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 477 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Gln Leu Leu Glu Lys 1 5 10 15 Arg Leu Ala His Leu Phe Ile Glu Trp Leu Ile Lys Gly Gly Pro Ser 20 25 30 Ser Ile Lys Pro Pro Pro Lys 35 <210> 478 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 478 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Gln Leu Leu Glu Lys 1 5 10 15 Arg Leu Ala His Leu Phe Ile Glu Trp Leu Leu Ala Gly Gly His Lys 20 25 30 Lys Gly Lys Pro Pro Pro Lys 35 <210> 479 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 479 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Gln Leu Leu Glu Lys 1 5 10 15 Arg Leu Ala His Leu Phe Ile Glu Trp Leu Leu Ala Gly Gly His Ser 20 25 30 Ser Gly Lys Leu Ser Pro Lys 35 <210> 480 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 480 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Gln Leu Leu Glu Lys 1 5 10 15 Arg Leu Ala His Leu Phe Ile Glu Trp Leu Leu Ala Gly Gly His Ser 20 25 30 Ser Ile Lys Pro Pro Pro Lys 35 <210> 481 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 481 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Gln Leu Leu Glu Lys 1 5 10 15 Arg Leu Ala His Leu Phe Ile Glu Trp Leu Leu Ala Gly Gly His Ser 20 25 30 Ser Ile Arg Pro Pro Pro Lys 35 <210> 482 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 482 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Gln Leu Leu Glu Lys 1 5 10 15 Arg Leu Ala His Leu Phe Ile Glu Trp Leu Leu Ala Gly Gly Pro Ser 20 25 30 Ser Gly Lys Pro Pro Pro Lys 35 <210> 483 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 483 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Gln Leu Leu Glu Lys 1 5 10 15 Arg Leu Ala His Leu Phe Ile Glu Trp Leu Leu Ala Gly Gly Pro Ser 20 25 30 Ser Gly Arg Pro Pro Pro Lys 35 <210> 484 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 484 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Gln Leu Leu Glu Lys 1 5 10 15 Arg Leu Ala His Leu Phe Ile Glu Trp Leu Leu Lys Gly Gly His Ser 20 25 30 Lys Gly Lys Pro Pro Pro Lys 35 <210> 485 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 485 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Gln Leu Leu Glu Lys 1 5 10 15 Arg Leu Ala His Leu Phe Ile Glu Trp Leu Leu Lys Gly Gly His Ser 20 25 30 Ser Gly Arg Pro Pro Pro Lys 35 <210> 486 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 486 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Gln Gln Leu Glu Glu 1 5 10 15 Glu Leu Val Arg Leu Phe Tyr Glu Trp Leu Ile Ala Gly Gly His Ser 20 25 30 Lys Gly Lys Pro Pro Pro Lys 35 <210> 487 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 487 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Gln Gln Leu Glu Glu 1 5 10 15 Glu Leu Val Arg Leu Phe Tyr Glu Trp Leu Ile Ala Gly Gly His Ser 20 25 30 Ser Ile Lys Pro Pro Pro Lys 35 <210> 488 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 488 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Gln Gln Leu Glu Lys 1 5 10 15 Glu Leu Val Arg Leu Phe Phe Glu Trp Leu Ile Ala Gly Gly His Ser 20 25 30 Lys Gly Lys Pro Pro Pro Lys 35 <210> 489 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 489 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Gln Gln Leu Glu Lys 1 5 10 15 Glu Leu Val Arg Leu Phe Phe Glu Trp Leu Ile Ala Gly Gly His Ser 20 25 30 Ser Ile Lys Pro Pro Pro Lys 35 <210> 490 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 490 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Gln Gln Leu Glu Lys 1 5 10 15 Glu Leu Val Arg Leu Phe Tyr Glu Trp Leu Ile Ala Gly Gly His Ser 20 25 30 Lys Ile Lys Pro Pro Pro Lys 35 <210> 491 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 491 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Gln Gln Leu Glu Lys 1 5 10 15 Glu Leu Val Arg Leu Phe Tyr Glu Trp Leu Lys Ala Gly Gly His Ser 20 25 30 Lys Gly Lys Pro Pro Pro Lys 35 <210> 492 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 492 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Gln Gln Leu Glu Lys 1 5 10 15 Glu Leu Val Arg Leu Phe Tyr Glu Trp Leu Lys Ala Gly Gly His Ser 20 25 30 Ser Ile Lys Pro Pro Pro Lys 35 <210> 493 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 493 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Gln Gln Leu Glu Lys 1 5 10 15 Glu Leu Val Arg Leu Phe Tyr Glu Trp Leu Leu Ala Gly Gly His Ser 20 25 30 Ser Ile Lys Pro Pro Pro Lys 35 <210> 494 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 494 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Gln Gln Leu Glu Lys 1 5 10 15 Arg Leu Ala Arg Leu Phe Tyr Glu Trp Leu Ile Ala Gly Gly His Ser 20 25 30 Lys Ile Lys Pro Pro Pro Lys 35 <210> 495 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 495 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Gln Gln Leu Glu Lys 1 5 10 15 Arg Leu Ala Arg Leu Phe Tyr Glu Trp Leu Lys Ala Gly Gly His Ser 20 25 30 Lys Gly Lys Pro Pro Pro Lys 35 <210> 496 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 496 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Gln Gln Leu Glu Lys 1 5 10 15 Arg Leu Ala Arg Leu Phe Tyr Glu Trp Leu Lys Ala Gly Gly His Ser 20 25 30 Ser Ile Lys Pro Pro Pro Lys 35 <210> 497 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 497 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Gln Gln Leu Glu Lys 1 5 10 15 Arg Leu Val Arg Leu Phe Tyr Glu Trp Leu Ile Lys Gly Gly His Ser 20 25 30 Lys Ile Lys Pro Pro Pro Lys 35 <210> 498 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 498 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Gln Gln Leu Glu Lys 1 5 10 15 Arg Leu Val Arg Leu Phe Tyr Glu Trp Leu Ile Asn Gly Gly His Ser 20 25 30 Lys Ile Lys Pro Pro Pro Lys 35 <210> 499 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 499 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Gln Gln Leu Glu Lys 1 5 10 15 Arg Leu Val Arg Leu Phe Tyr Glu Trp Leu Ile Asn Gly Gly His Ser 20 25 30 Ser Ile Arg Pro Pro Pro Lys 35 <210> 500 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 500 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Gln Gln Leu Glu Lys 1 5 10 15 Arg Leu Val Arg Leu Phe Tyr Glu Trp Leu Lys Lys Gly Gly His Ser 20 25 30 Lys Gly Lys Pro Pro Pro Lys 35 <210> 501 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 501 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Gln Gln Leu Glu Lys 1 5 10 15 Arg Leu Val Arg Leu Phe Tyr Glu Trp Leu Lys Lys Gly Gly His Ser 20 25 30 Ser Ile Lys Pro Pro Pro Lys 35 <210> 502 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 502 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Gln Gln Leu Glu Lys 1 5 10 15 Arg Leu Val Arg Leu Phe Tyr Glu Trp Leu Lys Asn Gly Gly His Ser 20 25 30 Lys Gly Lys Pro Pro Pro Lys 35 <210> 503 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 503 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Gln Gln Leu Glu Lys 1 5 10 15 Arg Leu Val Arg Leu Phe Tyr Glu Trp Leu Lys Asn Gly Gly His Ser 20 25 30 Ser Ile Lys Pro Pro Pro Lys 35 <210> 504 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 504 His Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Gln Gln Leu Glu Lys 1 5 10 15 Arg Arg Val Arg Leu Phe Tyr Glu Trp Leu Lys Ala Gly Gly His Ser 20 25 30 Lys Gly Lys Pro Pro Pro Lys 35 <210> 505 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 505 His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Ile Leu Leu Asp Glu 1 5 10 15 Glu Ala Val Gln Leu Phe Ile Glu Trp Leu Leu Ala Thr Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 506 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 506 His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Ile Leu Leu Asp Glu 1 5 10 15 Glu Ala Val Gln Leu Phe Ile Glu Trp Leu Leu Ala Thr Gly Pro Val 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 507 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 507 His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Ile Leu Leu Asp Glu 1 5 10 15 Glu Ala Val Arg Glu Phe Ile Glu Trp Leu Leu Ala Thr Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 508 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 508 His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Ile Leu Leu Asp Glu 1 5 10 15 Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Leu Ala Thr Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 509 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 509 His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Ile Leu Leu Asp Glu 1 5 10 15 Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Leu Ala Thr Gly Pro Val 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 510 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 510 His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Ile Leu Leu Glu Glu 1 5 10 15 Glu Ala Val Arg Glu Phe Ile Glu Trp Leu Leu Ala Thr Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 511 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 511 His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Ile Leu Leu Glu Glu 1 5 10 15 Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Leu Ala Thr Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 512 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 512 His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Ile Leu Leu Glu Glu 1 5 10 15 Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Leu Ala Thr Gly Pro Val 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 513 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 513 His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Ile Gln Leu Ala Lys 1 5 10 15 Arg Leu Ala Gln Leu Phe Ile Glu Trp Leu Ile Lys Gly Gly His Ser 20 25 30 Ser Gly Lys Pro Pro Pro Lys 35 <210> 514 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 514 His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Ile Gln Leu Asp Glu 1 5 10 15 Glu Ala Val Gln Glu Phe Ile Glu Trp Leu Leu Ala Thr Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 515 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 515 His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Ile Gln Leu Asp Glu 1 5 10 15 Glu Ala Val Gln Leu Phe Ile Glu Trp Leu Leu Ala Thr Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 516 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 516 His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Ile Gln Leu Asp Glu 1 5 10 15 Glu Ala Val Gln Leu Phe Ile Glu Trp Leu Leu Ala Thr Gly Pro Val 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 517 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 517 His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Ile Gln Leu Asp Glu 1 5 10 15 Glu Ala Val Arg Glu Phe Ile Glu Trp Leu Leu Ala Thr Gly Pro Val 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 518 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 518 His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Ile Gln Leu Asp Glu 1 5 10 15 Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Glu Ala Thr Gly Pro Val 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 519 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 519 His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Ile Gln Leu Asp Glu 1 5 10 15 Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Leu Ala Thr Gly Pro Val 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 520 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 520 His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Ile Gln Leu Glu Glu 1 5 10 15 Glu Ala Val Gln Glu Phe Ile Glu Trp Leu Leu Ala Thr Gly Pro Val 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 521 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 521 His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Ile Gln Leu Glu Glu 1 5 10 15 Glu Ala Val Gln Leu Phe Ile Glu Trp Leu Leu Ala Thr Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 522 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 522 His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Ile Gln Leu Glu Glu 1 5 10 15 Glu Ala Val Gln Leu Phe Ile Glu Trp Leu Leu Ala Thr Gly Pro Val 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 523 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 523 His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Leu Ala Glu 1 5 10 15 Arg Leu Val Arg Leu Phe Ile Glu Trp Leu Ile Lys Gly Gly His Ser 20 25 30 Ser Gly Lys Pro Pro Pro Lys 35 <210> 524 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 524 His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Leu Ala Lys 1 5 10 15 Arg Leu Val Arg Glu Phe Ile Glu Trp Leu Ile Glu Gly Gly His Ser 20 25 30 Ser Gly Lys Pro Pro Pro Lys 35 <210> 525 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLG Peptide <400> 525 His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Leu Ala Lys 1 5 10 15 Arg Leu Val Arg Glu Phe Ile Glu Trp Leu Ile Glu Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 526 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 526 His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Leu Ala Lys 1 5 10 15 Arg Leu Val Arg Glu Phe Ile Glu Trp Leu Ile Lys Gly Gly His Ser 20 25 30 Ser Gly Lys Pro Pro Pro Lys 35 <210> 527 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 527 His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Leu Ala Lys 1 5 10 15 Arg Leu Val Arg Leu Phe Ile Glu Trp Leu Ile Lys Gly Gly His Ser 20 25 30 Ser Gly Lys Pro Pro Pro Lys 35 <210> 528 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 528 His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Leu Glu Glu 1 5 10 15 Glu Ala Val Gln Leu Phe Ile Glu Trp Leu Leu Ala Thr Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 529 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 529 His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Leu Glu Glu 1 5 10 15 Glu Ala Val Gln Leu Phe Ile Glu Trp Leu Leu Ala Thr Gly Pro Ser 20 25 30 Ser Gly Glu Pro Pro Pro Lys 35 <210> 530 <211> 40 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 530 His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Leu Glu Glu 1 5 10 15 Glu Ala Val Gln Leu Phe Ile Glu Trp Leu Leu Ala Thr Gly Pro Ser 20 25 30 Ser Gly Glu Pro Pro Pro Lys Ser 35 40 <210> 531 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 531 His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Leu Glu Glu 1 5 10 15 Glu Ala Val Gln Leu Phe Ile Glu Trp Leu Leu Ala Thr Gly Pro Ser 20 25 30 Ser Gly Lys Pro Pro Pro Glu 35 <210> 532 <211> 40 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 532 His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Leu Glu Glu 1 5 10 15 Glu Ala Val Gln Leu Phe Ile Glu Trp Leu Leu Ala Thr Gly Pro Ser 20 25 30 Ser Gly Lys Pro Pro Pro Glu Ser 35 40 <210> 533 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 533 His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Leu Glu Glu 1 5 10 15 Glu Ala Val Gln Leu Phe Ile Glu Trp Leu Leu Ala Thr Gly Pro Ser 20 25 30 Ser Gly Lys Pro Pro Pro Lys 35 <210> 534 <211> 40 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 534 His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Leu Glu Glu 1 5 10 15 Glu Ala Val Gln Leu Phe Ile Glu Trp Leu Leu Ala Thr Gly Pro Ser 20 25 30 Ser Gly Lys Pro Pro Pro Lys Ser 35 40 <210> 535 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 535 His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Leu Glu Glu 1 5 10 15 Glu Ala Val Gln Leu Phe Ile Glu Trp Leu Leu Asn Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Glu 35 <210> 536 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 536 His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Leu Glu Glu 1 5 10 15 Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Leu Ala Thr Gly Pro Ser 20 25 30 Ser Gly Glu Pro Pro Pro Glu 35 <210> 537 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 537 His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Leu Glu Glu 1 5 10 15 Arg Leu Ala Arg Leu Phe Tyr Glu Trp Leu Ile Ala Gly Gly His Ser 20 25 30 Ser Gln Lys Pro Pro Pro Lys 35 <210> 538 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 538 His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Leu Glu Lys 1 5 10 15 Glu Leu Val Arg Leu Phe Tyr Glu Trp Leu Ile Ala Gly Gly His Lys 20 25 30 Ser Gln Lys Pro Pro Pro Lys 35 <210> 539 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 539 His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Leu Glu Lys 1 5 10 15 Glu Leu Val Arg Leu Phe Tyr Glu Trp Leu Ile Ala Gly Gly His Ser 20 25 30 Ser Gln Arg Pro Pro Pro Lys 35 <210> 540 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 540 His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Leu Glu Lys 1 5 10 15 Glu Leu Val Arg Leu Phe Tyr Glu Trp Leu Ile Lys Gly Gly His Lys 20 25 30 Ser Gly Lys Pro Pro Pro Lys 35 <210> 541 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 541 His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Leu Glu Lys 1 5 10 15 Glu Leu Val Arg Leu Phe Tyr Glu Trp Leu Ile Lys Gly Gly His Ser 20 25 30 Lys Gly Lys Pro Pro Pro Lys 35 <210> 542 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 542 His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Leu Glu Lys 1 5 10 15 Glu Leu Val Arg Leu Phe Tyr Glu Trp Leu Ile Lys Gly Gly His Ser 20 25 30 Ser Gly Arg Pro Pro Pro Lys 35 <210> 543 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 543 His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Leu Glu Lys 1 5 10 15 Glu Leu Val Arg Leu Phe Tyr Glu Trp Leu Ile Lys Gly Gly His Ser 20 25 30 Ser Ile Lys Pro Pro Pro Lys 35 <210> 544 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 544 His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Leu Glu Lys 1 5 10 15 Glu Leu Val Arg Leu Phe Tyr Glu Trp Leu Ile Lys Gly Gly His Ser 20 25 30 Ser Gln Lys Pro Pro Pro Lys 35 <210> 545 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 545 His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Leu Glu Lys 1 5 10 15 Glu Leu Val Arg Leu Phe Tyr Glu Trp Leu Ile Asn Gly Gly His Lys 20 25 30 Ser Gly Lys Pro Pro Pro Lys 35 <210> 546 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 546 His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Leu Glu Lys 1 5 10 15 Glu Leu Val Arg Leu Phe Tyr Glu Trp Leu Ile Asn Gly Gly His Ser 20 25 30 Lys Gly Lys Pro Pro Pro Lys 35 <210> 547 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 547 His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Leu Glu Lys 1 5 10 15 Glu Leu Val Arg Leu Phe Tyr Glu Trp Leu Ile Asn Gly Gly His Ser 20 25 30 Ser Gly Lys Pro Pro Pro Lys 35 <210> 548 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 548 His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Leu Glu Lys 1 5 10 15 Glu Leu Val Arg Leu Phe Tyr Glu Trp Leu Ile Asn Gly Gly His Ser 20 25 30 Ser Gln Lys Pro Pro Pro Lys 35 <210> 549 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 549 His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Leu Glu Lys 1 5 10 15 Glu Leu Val Arg Leu Phe Tyr Glu Trp Leu Ile Asn Gly Gly Pro Ser 20 25 30 Ser Gly Lys Pro Pro Pro Lys 35 <210> 550 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 550 His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Leu Glu Lys 1 5 10 15 Glu Leu Val Arg Leu Phe Tyr Glu Trp Leu Lys Ala Gly Gly His Ser 20 25 30 Ser Gly Lys Pro Pro Pro Lys 35 <210> 551 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 551 His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Leu Glu Lys 1 5 10 15 Arg Leu Val Arg Leu Phe Tyr Glu Trp Leu Lys Asn Gly Gly His Ser 20 25 30 Ser Gly Lys Pro Pro Pro Lys 35 <210> 552 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 552 His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Leu Glu Lys 1 5 10 15 Arg Leu Val Arg Leu Phe Tyr Glu Trp Leu Leu Asn Gly Gly His Ser 20 25 30 Ser Gln Lys Pro Pro Pro Lys 35 <210> 553 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 553 His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Glu 1 5 10 15 Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 554 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 554 His Ser Glu Gly Thr Phe Thr Ser Asp Lys Ser Lys Gln Leu Ala Lys 1 5 10 15 Arg Leu Val Arg Leu Phe Ile Glu Trp Leu Ile Lys Gly Gly His Ser 20 25 30 Ser Gly Lys Pro Pro Pro Lys 35 <210> 555 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 555 His Ser Gln Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Leu Glu Ser 1 5 10 15 Arg Arg Ala Arg Arg Phe Ile Glu Trp Leu Leu Ala Thr Gly Pro Glu 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 556 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 556 Tyr Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Lys Leu Leu Glu Lys 1 5 10 15 Arg Leu Ala His Leu Phe Ile Glu Trp Leu Ile Ala Gly Gly His Ser 20 25 30 Ser Gly Lys Pro Pro Pro Lys 35 <210> 557 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 557 Tyr Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Lys Leu Leu Glu Lys 1 5 10 15 Arg Leu Val Arg Leu Phe Ile Glu Trp Leu Ile Ala Gly Gly His Ser 20 25 30 Ser Gly Lys Pro Pro Pro Lys 35 <210> 558 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 558 Tyr Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Lys Gln Leu Glu Lys 1 5 10 15 Arg Leu Val Arg Leu Phe Ile Glu Trp Leu Ile Ala Gly Gly His Ser 20 25 30 Ser Gly Lys Pro Pro Pro Lys 35 <210> 559 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 559 Tyr Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Lys Gln Leu Glu Lys 1 5 10 15 Arg Leu Val Arg Leu Phe Ile Glu Trp Leu Ile Lys Gly Gly His Ser 20 25 30 Ser Gly Lys Pro Pro Pro Lys 35 <210> 560 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 560 Tyr Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Gln Leu Leu Glu Glu 1 5 10 15 Arg Leu Ala His Leu Phe Ile Glu Trp Leu Ile Ala Gly Gly His Ser 20 25 30 Lys Ile Arg Pro Pro Pro Lys 35 <210> 561 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 561 Tyr Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Gln Leu Leu Glu Glu 1 5 10 15 Arg Leu Val His Leu Phe Ile Glu Trp Leu Ile Ala Gly Gly His Ser 20 25 30 Lys Ile Lys Pro Pro Pro Lys 35 <210> 562 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 562 Tyr Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Gln Leu Leu Glu Lys 1 5 10 15 Glu Leu Ala His Leu Phe Ile Glu Trp Leu Ile Ala Gly Gly His Lys 20 25 30 Ser Gly Arg Pro Ser Pro Lys 35 <210> 563 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 563 Tyr Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Gln Leu Leu Glu Lys 1 5 10 15 Arg Leu Ala His Leu Phe Ile Glu Trp Leu Ile Lys Gly Gly His Ser 20 25 30 Ser Ile Lys Pro Pro Pro Lys 35 <210> 564 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 564 Tyr Gly Glu Gly Thr Phe Thr Ser Asp Lys Ser Gln Leu Leu Glu Lys 1 5 10 15 Arg Leu Ala His Leu Phe Ile Glu Trp Leu Ile Lys Gly Gly His Ser 20 25 30 Ser Ile Arg Pro Pro Pro Lys 35 <210> 565 <211> 44 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 565 Tyr Ser Glu Gly Thr Phe Thr Ser Asp Leu Ser Ile Leu Cys Glu Lys 1 5 10 15 Arg Ala Val His Glu Phe Ile Glu Trp Leu Ile Ala Gly Gly Pro Ser 20 25 30 Ser Gly Lys Pro Pro Pro Lys Pro Gly Cys Gly Ser 35 40 <210> 566 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Peptide Extension <400> 566 His Lys Lys Gly Lys Pro Pro Pro Lys 1 5 <210> 567 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Peptide Extension <400> 567 His Lys Lys Gly Lys Tyr Pro Pro Lys 1 5 <210> 568 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Peptide Extension <400> 568 His Lys Lys Ile Lys Pro Pro Pro Lys 1 5 <210> 569 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Peptide Extension <400> 569 His Lys Ser Gly Lys Pro Pro Pro Lys 1 5 <210> 570 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Peptide Extension <400> 570 His Lys Ser Gly Lys Tyr Ser Pro Lys 1 5 <210> 571 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Peptide Extension <400> 571 His Lys Ser Gly Arg Pro Ser Pro Lys 1 5 <210> 572 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Peptide Extension <400> 572 His Lys Ser Gln Lys Pro Pro Pro Lys 1 5 <210> 573 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Peptide Extension <400> 573 His Pro Ser Gly Lys Pro Pro Pro Lys 1 5 <210> 574 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> Peptide Extension <400> 574 His Ser Gly Lys Pro Pro Pro Lys 1 5 <210> 575 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Peptide Extension <400> 575 His Ser Lys Gly Lys Pro Pro Pro Lys 1 5 <210> 576 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Peptide Extension <400> 576 His Ser Lys Gly Lys Tyr Pro Pro Lys 1 5 <210> 577 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Peptide Extension <400> 577 His Ser Lys Gly Arg Leu Pro Pro Lys 1 5 <210> 578 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Peptide Extension <400> 578 His Ser Lys Gly Arg Pro Pro Pro Lys 1 5 <210> 579 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Peptide Extension <400> 579 His Ser Lys Ile Lys Pro Pro Pro Lys 1 5 <210> 580 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Peptide Extension <400> 580 His Ser Lys Ile Lys Tyr Pro Pro Lys 1 5 <210> 581 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Peptide Extension <400> 581 His Ser Lys Ile Arg Pro Pro Pro Lys 1 5 <210> 582 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Peptide Extension <400> 582 His Ser Lys Gln Lys Pro Pro Pro Lys 1 5 <210> 583 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Peptide Extension <400> 583 His Ser Ser Gly Lys Leu Pro Pro Lys 1 5 <210> 584 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Peptide Extension <400> 584 His Ser Ser Gly Lys Leu Ser Pro Lys 1 5 <210> 585 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Peptide Extension <400> 585 His Ser Ser Gly Lys Pro Pro Pro Lys 1 5 <210> 586 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> Peptide Extension <400> 586 His Ser Ser Gly Lys Pro Pro Pro Lys Gly 1 5 10 <210> 587 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Peptide Extension <400> 587 His Ser Ser Gly Lys Pro Pro Pro Ser 1 5 <210> 588 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Peptide Extension <400> 588 His Ser Ser Gly Arg Leu Ser Pro Lys 1 5 <210> 589 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Peptide Extension <400> 589 His Ser Ser Gly Arg Pro Pro Pro Lys 1 5 <210> 590 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Peptide Extension <400> 590 His Ser Ser Gly Arg Tyr Pro Pro Lys 1 5 <210> 591 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Peptide Extension <400> 591 His Ser Ser Gly Arg Tyr Ser Pro Lys 1 5 <210> 592 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Peptide Extension <400> 592 His Ser Ser Ile Lys Pro Pro Pro Lys 1 5 <210> 593 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Peptide Extension <400> 593 His Ser Ser Ile Arg Pro Pro Pro Lys 1 5 <210> 594 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Peptide Extension <400> 594 His Ser Ser Gln Lys Pro Pro Pro Lys 1 5 <210> 595 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Peptide Extension <400> 595 His Ser Ser Gln Arg Pro Pro Pro Lys 1 5 <210> 596 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Peptide Extension <400> 596 Lys Ser Lys Gly Lys Pro Lys Pro Lys 1 5 <210> 597 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Peptide Extension <400> 597 Pro Glu Ser Gly Ala Pro Pro Pro Ser 1 5 <210> 598 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> Peptide Extension <400> 598 Pro Lys Lys Ile Arg Tyr Ser 1 5 <210> 599 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> Peptide Extension <400> 599 Pro Lys Lys Gln Arg Leu Ser 1 5 <210> 600 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> Peptide Extension <400> 600 Pro Ser Lys Glu Ile Ile Ser 1 5 <210> 601 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Peptide Extension <400> 601 Pro Ser Lys Gly Lys Pro Pro Pro Lys 1 5 <210> 602 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Peptide Extension <400> 602 Pro Ser Lys Gly Arg Pro Pro Pro Lys 1 5 <210> 603 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Peptide Extension <400> 603 Pro Ser Lys Ile Lys Pro Pro Pro Lys 1 5 <210> 604 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Peptide Extension <400> 604 Pro Ser Ser Gly Ala Pro Pro Pro Glu 1 5 <210> 605 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Peptide Extension <400> 605 Pro Ser Ser Gly Ala Pro Pro Pro Ser 1 5 <210> 606 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Peptide Extension <400> 606 Pro Ser Ser Gly Glu Pro Pro Pro Glu 1 5 <210> 607 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Peptide Extension <400> 607 Pro Ser Ser Gly Glu Pro Pro Pro Lys 1 5 <210> 608 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> Peptide Extension <400> 608 Pro Ser Ser Gly Glu Pro Pro Pro Lys Ser 1 5 10 <210> 609 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Peptide Extension <400> 609 Pro Ser Ser Gly Lys Leu Pro Pro Lys 1 5 <210> 610 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Peptide Extension <400> 610 Pro Ser Ser Gly Lys Pro Lys Pro Lys 1 5 <210> 611 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Peptide Extension <400> 611 Pro Ser Ser Gly Lys Pro Pro Pro Glu 1 5 <210> 612 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> Peptide Extension <400> 612 Pro Ser Ser Gly Lys Pro Pro Pro Glu Ser 1 5 10 <210> 613 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Peptide Extension <400> 613 Pro Ser Ser Gly Lys Pro Pro Pro Lys 1 5 <210> 614 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> Peptide Extension <400> 614 Pro Ser Ser Gly Lys Pro Pro Pro Lys Pro Gly Cys Gly Ser 1 5 10 <210> 615 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> Peptide Extension <400> 615 Pro Ser Ser Gly Lys Pro Pro Pro Lys Ser 1 5 10 <210> 616 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Peptide Extension <400> 616 Pro Ser Ser Gly Lys Tyr Ser Pro Lys 1 5 <210> 617 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Peptide Extension <400> 617 Pro Ser Ser Gly Arg Pro Pro Pro Lys 1 5 <210> 618 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Peptide Extension <400> 618 Pro Ser Ser Gly Arg Tyr Pro Pro Lys 1 5 <210> 619 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Peptide Extension <400> 619 Pro Ser Ser Ile Lys Pro Pro Pro Lys 1 5 <210> 620 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Peptide Extension <400> 620 Pro Val Ser Gly Ala Pro Pro Pro Ser 1 5 <210> 621 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> Peptide Extension <400> 621 Pro Val Ser Gly Ala Pro Pro Ser Lys Lys Lys Lys Lys Lys 1 5 10 <210> 622 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 622 His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Glu 1 5 10 15 Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 623 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 623 His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Leu Glu Glu 1 5 10 15 Glu Ala Val Gln Leu Phe Ile Glu Trp Leu Leu Ala Thr Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 624 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 624 His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Ile Gln Leu Asp Glu 1 5 10 15 Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Leu Ala Thr Gly Pro Val 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 625 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 625 His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Ile Gln Leu Asp Glu 1 5 10 15 Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Glu Ala Thr Gly Pro Val 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 626 <211> 40 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 626 Gly His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Ile Gln Leu Glu 1 5 10 15 Glu Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Leu Ala Gly Gly Pro 20 25 30 Ser Ser Gly Ala Pro Pro Pro Ser 35 40 <210> 627 <211> 40 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 627 Gly His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Ile Gln Leu Glu 1 5 10 15 Glu Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Leu Ala Thr Gly Pro 20 25 30 Ser Ser Gly Ala Pro Pro Pro Ser 35 40 <210> 628 <211> 40 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 628 His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Leu Glu Glu 1 5 10 15 Glu Ala Val Gln Leu Phe Ile Glu Trp Leu Leu Ala Thr Gly Pro Ser 20 25 30 Ser Gly Glu Pro Pro Pro Glu Ser 35 40 <210> 629 <211> 30 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 629 His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Glu 1 5 10 15 Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn Gly Gly 20 25 30 <210> 630 <211> 30 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 630 His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Leu Glu Glu 1 5 10 15 Glu Ala Val Gln Leu Phe Ile Glu Trp Leu Leu Ala Thr Gly 20 25 30 <210> 631 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 631 His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Leu Glu Glu 1 5 10 15 Glu Ala Val Gln Leu Phe Ile Glu Trp Leu Leu Ala Thr Gly Pro Ser 20 25 30 Ser Gly Glu Pro Pro Pro Glu 35 <210> 632 <211> 40 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 632 Gly His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Leu Glu 1 5 10 15 Glu Glu Arg Val Gln Glu Phe Ile Glu Trp Leu Val Lys Gly Arg Pro 20 25 30 Ser Ser Gly Ala Pro Pro Pro Ser 35 40 <210> 633 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 633 His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Leu Glu Glu 1 5 10 15 Glu Ala Val Gln Leu Phe Ile Glu Trp Leu Glu Ala Thr Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 634 <211> 38 <212> PRT <213> Artificial Sequence <220> <223> GLP Peptide <400> 634 Gly His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Ile Gln Leu Glu 1 5 10 15 Glu Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Leu Ala Gly Gly Pro 20 25 30 Lys Lys Gln Arg Leu Ser 35 <210> 635 <211> 30 <212> PRT <213> Artificial Sequence <220> <223> General Sequence I <220> <221> misc_feature <222> (1)..(1) <223> Xaa is H, Y or F <220> <221> misc_feature <222> (10)..(10) <223> Xaa is K or L <220> <221> misc_feature <222> (12)..(12) <223> Xaa is K, I or Q <220> <221> misc_feature <222> (13)..(13) <223> Xaa is Q or L <220> <221> misc_feature <222> (15)..(15) <223> Xaa is E, A or D <220> <221> misc_feature <222> (16)..(16) <223> Xaa is E, K or S <220> <221> misc_feature <222> (17)..(17) <223> Xaa is E, R or Q <220> <221> misc_feature <222> (18)..(18) <223> Xaa L, A or R <220> <221> misc_feature <222> (19)..(19) <223> Xaa is V, A or F <220> <221> misc_feature <222> (20)..(20) <223> Xaa is R, H, Q, K or I <220> <221> misc_feature <222> (21)..(21) <223> Xaa is L, E, H or R <220> <221> misc_feature <222> (23)..(23) <223> Xaa is I, Y or F <220> <221> misc_feature <222> (27)..(27) <223> Xaa is I, L, K or E <220> <221> misc_feature <222> (28)..(28) <223> Xaa is A, K, N or E <220> <221> misc_feature <222> (29)..(29) <223> Xaa is G, T, K or V <400> 635 Xaa Gly Glu Gly Thr Phe Thr Ser Asp Xaa Ser Xaa Xaa Leu Xaa Xaa 1 5 10 15 Xaa Xaa Xaa Xaa Xaa Phe Xaa Glu Trp Leu Xaa Xaa Xaa Gly 20 25 30 <210> 636 <211> 30 <212> PRT <213> Artificial Sequence <220> <223> General Sequence II <220> <221> misc_feature <222> (10)..(10) <223> Xaa is K or L <220> <221> misc_feature <222> (18)..(18) <223> Xaa is A or R <220> <221> misc_feature <222> (20)..(20) <223> Xaa is R or Q <220> <221> misc_feature <222> (29)..(29) <223> Xaa is G or T <400> 636 His Gly Glu Gly Thr Phe Thr Ser Asp Xaa Ser Lys Gln Leu Glu Glu 1 5 10 15 Glu Xaa Val Xaa Leu Phe Ile Glu Trp Leu Lys Ala Xaa Gly 20 25 30

Claims

천연 GLP-1(7-36)(서열번호: 260)의 GLP-1R 효능제 활성과 비교하여 약 9배 내지 약 531배 감소된 GLP-1R(글루카곤-유사 펩티드-1 수용체) 효능제 활성을 갖는 GLP-1R 효능제 펩티드로서, 하기 아미노산 서열
X₁-G-E-G-T-F-T-S-D-X₁₀-S-X₁₂-X₁₃-L-X₁₅-X₁₆-X₁₇-X₁₈-X₁₉-X₂₀-X₂₁-F-X₂₃-E-W-L-X₂₇-X₂₈-X₂₉-G(서열번호: 635)를 포함하거나 또는 이들로 이루어지고,
여기서
X₁은 H, Y 또는 F이고,
X₁₀은 K 또는 L이고,
X₁₂는 K, I 또는 Q이고,
X₁₃ 은 Q 또는 L이고,
X₁₅ 는 E, A 또는 D이고,
X₁₆ 은 E, K 또는 S이고,
X₁₇ 은 E, R 또는 Q이고,
X₁₈ 은 L, A 또는 R이고,
X₁₉ 는 V, A 또는 F이고,
X₂₀ 은 R, H, Q, K 또는 I이고,
X₂₁ 은 L, E, H 또는 R이고,
X₂₃ 은 I, Y 또는 F이고,
X₂₇ 은 I, L, K 또는 E이고,
X₂₈ 은 A, K, N 또는 E이고,
X₂₉ 는 G, T, K 또는 V이고;
선택적으로, 상기 아미노산 서열은 N-말단에 적어도 하나의 추가 아미노산 잔기를 추가로 포함하고;
선택적으로, 상기 아미노산 서열은 C-말단에 최대 약 12개, 약 11개 또는 약 10개의 아미노산 잔기로 이루어진 펩티드 연장부를 추가로 포함하는 것인,
GLP-1R 효능제 펩티드.
제1항에 있어서, 하기 아미노산 서열
H-G-E-G-T-F-T-S-D-X₁₀-S-K-Q-L-E-E-E-X₁₈-V-X₂₀-L-F-I-E-W-L-K-A-X₂₉-G(서열번호: 636)을 포함하거나 또는 이들로 이루어지고,
여기서
X₁₀은 K 또는 L이고,
X₁₈은 A 또는 R이고,
X₂₀은 R 또는 Q이고,
X₂₉는 G 또는 T이고;
선택적으로, 상기 아미노산 서열은 N-말단에 적어도 하나의 추가 아미노산 잔기를 추가로 포함하고;
선택적으로, 상기 아미노산 서열은 C-말단에 최대 약 12개, 약 11개 또는 약 10개의 아미노산 잔기로 이루어진 펩티드 연장부를 추가로 포함하는 것인,
GLP-1R 효능제 펩티드.
제1항 또는 제2항에 있어서, 적어도 하나의 추가 아미노산 잔기가 G 또는 A인, GLP-1R 효능제 펩티드.
제1항 내지 제3항 중 어느 한 항에 있어서, 상기 펩티드 연장부가 서열번호: 566 내지 621로 이루어진 군으로부터 선택되는 아미노산 서열로 이루어진 것인, GLP-1R 효능제 펩티드.
제1항 내지 제4항 중 어느 한 항에 있어서, GLP-1R 효능제 펩티드가 분리된 형태일 때 및/또는 GLP-1R 효능제 펩티드가 융합 분자의 일부일 때 천연 GLP-1(7-36)(서열번호: 260)의 GLP-1R 효능제 활성과 비교하여 약 9배 내지 약 531배 감소된 GLP-1R 효능제 활성을 갖는 것인, GLP-1R 효능제 펩티드.
제1항 내지 제5항 중 어느 한 항에 있어서, 천연 GLP-1(7-36)(서열번호: 260)의 GLP-1R 효능제 활성과 비교하여 약 10배 내지 약 500배 또는 약 15 내지 약 500배 또는 약 20배 내지 약 500배 또는 약 50배 내지 약 500배 또는 약 100배 내지 약 500배 또는 약 100배 내지 약 300배 감소된 GLP-1R 효능제 활성을 갖는 것인, GLP-1R 효능제 펩티드.
서열번호: 261 내지 552 및 554 내지 565로 이루어진 군으로부터 선택되는 아미노산 서열을 포함하거나 또는 이들로 이루어진 GLP-1R 효능제 펩티드.
서열번호: 261의 아미노산 서열을 포함하거나 또는 이들로 이루어지거나, 또는 서열번호: 262의 아미노산 서열을 포함하거나 또는 이들로 이루어진 GLP-1R 효능제 펩티드.
제1항 내지 제8항 중 어느 한 항에 따른 GLP-1R 효능제 펩티드 및 적어도 하나의 다른 활성 약제학적 성분을 포함하는 조합물.
제1항 내지 제8항 중 어느 한 항에 따른 GLP-1R 효능제 펩티드 및 적어도 하나의 다른 활성 약제학적 성분을 포함하는 융합 분자.
제1항 내지 제8항 중 어느 한 항에 따른 GLP-1R 효능제 펩티드 또는 제10항에 따른 융합 분자를 인코딩하는 핵산 분자.
제11항에 따른 핵산 분자를 포함하는 숙주 세포.
제1항 내지 제8항 중 어느 한 항에 따른 GLP-1R 효능제 펩티드, 제9항에 따른 조합물, 제10항에 따른 융합 분자, 제11항에 따른 핵산 분자 또는 제12항에 따른 숙주 세포를 포함하는 약제학적 조성물.
제1항 내지 제8항 중 어느 한 항에 따른 GLP-1R 효능제 펩티드, 제9항에 따른 조합물, 제10항에 따른 융합 분자, 제11항에 따른 핵산 분자, 제12항에 따른 숙주 세포 또는 제13항에 따른 약제학적 조성물을 포함하는 키트.
약제로 사용하기 위한 제1항 내지 제8항 중 어느 한 항에 따른 GLP-1R 효능제 펩티드, 제9항에 따른 조합물, 제10항에 따른 융합 분자, 제11항에 따른 핵산 분자, 제12항에 따른 숙주 세포 또는 제13항에 따른 약제학적 조성물.
비만, 과체중, 대사 증후군, 진성 당뇨병, 고혈당증, 이상지질혈증, 비알코올성 지방간염(NASH) 및 죽상동맥경화증으로 이루어진 군으로부터 선택되는 질환 또는 장애의 치료에 사용하기 위한, 제1항 내지 제8항 중 어느 한 항에 따른 GLP-1R 효능제 펩티드, 제9항에 따른 조합물, 제10항에 따른 융합 분자, 제11항에 따른 핵산 분자, 제12항에 따른 숙주 세포 또는 제13항에 따른 약제학적 조성물.
제16항에 있어서, 상기 진성 당뇨병이 1형 진성 당뇨병 또는 2형 진성 당뇨병인, GLP-1R 효능제 펩티드, 조합물, 융합 분자, 핵산 분자, 숙주 세포 또는 약제학적 조성물.