KR20230009873A - 니로가세스타트 및 bcma-지향 요법과의 병용 요법 및 이의 용도 - Google Patents

니로가세스타트 및 bcma-지향 요법과의 병용 요법 및 이의 용도 Download PDF

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KR20230009873A
KR20230009873A KR1020227034017A KR20227034017A KR20230009873A KR 20230009873 A KR20230009873 A KR 20230009873A KR 1020227034017 A KR1020227034017 A KR 1020227034017A KR 20227034017 A KR20227034017 A KR 20227034017A KR 20230009873 A KR20230009873 A KR 20230009873A
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bcma
dihydrobromide
nirogacestat
therapy
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Korean (ko)
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토드 웹스터 시어러
바드레딘 에드리스
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스프링웍스 테라퓨틱스, 인크.
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KR1020227034017A 2020-03-13 2021-03-12 니로가세스타트 및 bcma-지향 요법과의 병용 요법 및 이의 용도 Pending KR20230009873A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202062989372P 2020-03-13 2020-03-13
US62/989,372 2020-03-13
PCT/US2021/022177 WO2021183934A1 (en) 2020-03-13 2021-03-12 A combination therapy with nirogacestat and a bcma-directed therapy and uses thereof

Publications (1)

Publication Number Publication Date
KR20230009873A true KR20230009873A (ko) 2023-01-17

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KR1020227034017A Pending KR20230009873A (ko) 2020-03-13 2021-03-12 니로가세스타트 및 bcma-지향 요법과의 병용 요법 및 이의 용도

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US (1) US20230121547A1 (https=)
EP (1) EP4132515A1 (https=)
JP (2) JP7781764B2 (https=)
KR (1) KR20230009873A (https=)
CN (1) CN115916188A (https=)
AR (1) AR121566A1 (https=)
AU (1) AU2021236340A1 (https=)
BR (1) BR112022018251A2 (https=)
CA (1) CA3171267A1 (https=)
CL (1) CL2022002479A1 (https=)
CO (1) CO2022014388A2 (https=)
IL (1) IL296075A (https=)
MX (1) MX2022011258A (https=)
PE (1) PE20230614A1 (https=)
TW (1) TW202200132A (https=)
WO (1) WO2021183934A1 (https=)
ZA (1) ZA202209989B (https=)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2022339841A1 (en) 2021-09-01 2024-03-28 Springworks Therapeutics, Inc. Synthesis of nirogacestat
WO2023064872A1 (en) * 2021-10-14 2023-04-20 Precision Biosciences, Inc. Combinations of anti-bcma car t cells and gamma secretase inhibitors
CN118338900A (zh) * 2021-11-05 2024-07-12 斯普林渥克斯治疗有限公司 含尼罗加司他的组合物和治疗
CN118302412A (zh) * 2021-11-23 2024-07-05 梯瓦制药国际有限责任公司 Nirogacestat盐的固态形式
US11951096B2 (en) 2022-05-20 2024-04-09 Springworks Therapeutics, Inc. Treatments with nirogacestat
US12036207B2 (en) 2022-05-20 2024-07-16 Springworks Therapeutics, Inc. Treatments with nirogacestat
US12138246B2 (en) 2022-05-20 2024-11-12 Springworks Therapeutics, Inc. Treatments with nirogacestat
KR20250013187A (ko) * 2022-05-20 2025-01-31 스프링웍스 테라퓨틱스, 인크. 니로가세스타트를 사용한 치료
KR20250155587A (ko) * 2023-03-09 2025-10-30 크리스탈 파마슈티컬 (쑤저우) 씨오., 엘티디. 니로가세스타트 디히드로브로마이드의 결정형, 및 이의 제조 방법 및 이의 용도

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015120065A1 (en) * 2014-02-05 2015-08-13 The Trustees Of Columbia University In The City Of New York Gamma-secretase inhibition reduce apoc3 levels and plasma triglycerides
WO2017019496A1 (en) * 2015-07-24 2017-02-02 Berenson James Richard Gamma secretase modulators for the treatment of immune system dysfunction
MX2019009552A (es) * 2017-02-17 2019-10-02 Hutchinson Fred Cancer Res Terapias de combinacion para el tratamiento de canceres relacionados con el antigeno de maduracion de celulas b (bcma) y trastornos autoinmunitarios.
US20200179511A1 (en) * 2017-04-28 2020-06-11 Novartis Ag Bcma-targeting agent, and combination therapy with a gamma secretase inhibitor
EP3615055A1 (en) * 2017-04-28 2020-03-04 Novartis AG Cells expressing a bcma-targeting chimeric antigen receptor, and combination therapy with a gamma secretase inhibitor
CN110622566B (zh) * 2017-05-05 2021-04-20 华为技术有限公司 一种辅助数据传输方法、设备及系统
MX2020004568A (es) * 2017-11-06 2020-10-05 Juno Therapeutics Inc Combinación de una terapia celular y un inhibidor de gamma secretasa.
US11970542B2 (en) * 2017-11-08 2024-04-30 Fred Hutchinson Cancer Center Bispecific antibodies specific for treating hematological malignancies
US20210069194A1 (en) * 2018-01-17 2021-03-11 Mingsight Pharmaceuticals, Inc. Combination therapy for the treatment of cancer
EP3801551A4 (en) * 2018-05-24 2022-04-06 Ayala Pharmaceuticals Inc. COMPOSITIONS WITH BISFLUOROALKYL-1,4-BENZODIAZEPINONE COMPOUNDS AND IMMUNOTHERAPEUTICS AND METHODS OF USE THEREOF
KR102870868B1 (ko) * 2018-06-01 2025-10-15 노파르티스 아게 Bcma에 대한 결합 분자 및 이의 용도
CN113924318B (zh) * 2019-04-10 2025-06-20 葛兰素史密斯克莱知识产权发展有限公司 具有抗BCMA抗体和gamma分泌酶抑制剂的联合疗法
KR102772889B1 (ko) * 2019-08-09 2025-02-26 화이자 인코포레이티드 (s)-2-(((s)-6,8-디플루오로-1,2,3,4-테트라하이드로나프탈렌-2-일)아미노)-n-(1-(2-메틸-1-(네오펜틸아미노)프로판-2-일)-1h-이미다졸-4-일)펜탄아미드의 고체 상태 형태 및 이의 용도

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JP2025168430A (ja) 2025-11-07
TW202200132A (zh) 2022-01-01
PE20230614A1 (es) 2023-04-14
CO2022014388A2 (es) 2023-02-16
JP7781764B2 (ja) 2025-12-08
CN115916188A (zh) 2023-04-04
AR121566A1 (es) 2022-06-15
JP2023517243A (ja) 2023-04-24
AU2021236340A1 (en) 2022-09-29
MX2022011258A (es) 2023-01-11
BR112022018251A2 (pt) 2022-11-08
CL2022002479A1 (es) 2023-08-18
IL296075A (en) 2022-11-01
WO2021183934A1 (en) 2021-09-16
ZA202209989B (en) 2025-12-17
EP4132515A1 (en) 2023-02-15
US20230121547A1 (en) 2023-04-20
CA3171267A1 (en) 2021-09-16

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