KR20230009873A - 니로가세스타트 및 bcma-지향 요법과의 병용 요법 및 이의 용도 - Google Patents

니로가세스타트 및 bcma-지향 요법과의 병용 요법 및 이의 용도 Download PDF

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Publication number
KR20230009873A
KR20230009873A KR1020227034017A KR20227034017A KR20230009873A KR 20230009873 A KR20230009873 A KR 20230009873A KR 1020227034017 A KR1020227034017 A KR 1020227034017A KR 20227034017 A KR20227034017 A KR 20227034017A KR 20230009873 A KR20230009873 A KR 20230009873A
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South Korea
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bcma
dihydrobromide
nirogacestat
therapy
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Korean (ko)
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토드 웹스터 시어러
바드레딘 에드리스
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스프링웍스 테라퓨틱스, 인크.
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Publication of KR20230009873A publication Critical patent/KR20230009873A/ko
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    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the cancer treated
    • A61K2239/48—Blood cells, e.g. leukemia or lymphoma
    • A—HUMAN NECESSITIES
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  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
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KR1020227034017A 2020-03-13 2021-03-12 니로가세스타트 및 bcma-지향 요법과의 병용 요법 및 이의 용도 Pending KR20230009873A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202062989372P 2020-03-13 2020-03-13
US62/989,372 2020-03-13
PCT/US2021/022177 WO2021183934A1 (en) 2020-03-13 2021-03-12 A combination therapy with nirogacestat and a bcma-directed therapy and uses thereof

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Publication Number Publication Date
KR20230009873A true KR20230009873A (ko) 2023-01-17

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KR1020227034017A Pending KR20230009873A (ko) 2020-03-13 2021-03-12 니로가세스타트 및 bcma-지향 요법과의 병용 요법 및 이의 용도

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US (1) US20230121547A1 (https=)
EP (1) EP4132515A1 (https=)
JP (2) JP7781764B2 (https=)
KR (1) KR20230009873A (https=)
CN (1) CN115916188A (https=)
AR (1) AR121566A1 (https=)
AU (1) AU2021236340A1 (https=)
BR (1) BR112022018251A2 (https=)
CA (1) CA3171267A1 (https=)
CL (1) CL2022002479A1 (https=)
CO (1) CO2022014388A2 (https=)
IL (1) IL296075A (https=)
MX (1) MX2022011258A (https=)
PE (1) PE20230614A1 (https=)
TW (1) TW202200132A (https=)
WO (1) WO2021183934A1 (https=)
ZA (1) ZA202209989B (https=)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
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CA3230245A1 (en) 2021-09-01 2023-03-09 Springworks Therapeutics, Inc. Synthesis of nirogacestat
WO2023064872A1 (en) * 2021-10-14 2023-04-20 Precision Biosciences, Inc. Combinations of anti-bcma car t cells and gamma secretase inhibitors
CN118338900A (zh) * 2021-11-05 2024-07-12 斯普林渥克斯治疗有限公司 含尼罗加司他的组合物和治疗
CN118302412A (zh) * 2021-11-23 2024-07-05 梯瓦制药国际有限责任公司 Nirogacestat盐的固态形式
US12138246B2 (en) 2022-05-20 2024-11-12 Springworks Therapeutics, Inc. Treatments with nirogacestat
US11951096B2 (en) 2022-05-20 2024-04-09 Springworks Therapeutics, Inc. Treatments with nirogacestat
IL316750A (en) 2022-05-20 2025-01-01 Springworks Therapeutics Inc Treatments with Nirogesstat
US12036207B2 (en) 2022-05-20 2024-07-16 Springworks Therapeutics, Inc. Treatments with nirogacestat
EP4678635A1 (en) * 2023-03-09 2026-01-14 Crystal Pharmaceutical (Suzhou) Co., Ltd. Crystal form of nirogacestat dihydrobromate, and preparation method therefor and use thereof

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Publication number Priority date Publication date Assignee Title
US10149855B2 (en) * 2014-02-05 2018-12-11 The Trustees Of Columbia University In The City Of New York Gamma-secretase inhibition reduce APOC3 levels and plasma triglycerides
AU2016297793A1 (en) * 2015-07-24 2018-02-08 Oncotracker, Inc. Gamma secretase modulators for the treatment of immune system dysfunction
IL268349B2 (en) * 2017-02-17 2024-08-01 Hutchinson Fred Cancer Res Combination therapies for treatment of bcma-related cancers and autoimmune disorders
WO2018201056A1 (en) * 2017-04-28 2018-11-01 Novartis Ag Cells expressing a bcma-targeting chimeric antigen receptor, and combination therapy with a gamma secretase inhibitor
EP3615068A1 (en) * 2017-04-28 2020-03-04 Novartis AG Bcma-targeting agent, and combination therapy with a gamma secretase inhibitor
CN110622566B (zh) 2017-05-05 2021-04-20 华为技术有限公司 一种辅助数据传输方法、设备及系统
SG11202003427XA (en) * 2017-11-06 2020-05-28 Juno Therapeutics Inc Combination of a cell therapy and a gamma secretase inhibitor
WO2019094626A1 (en) * 2017-11-08 2019-05-16 Fred Hutchinson Cancer Research Center Bispecific antibody compositions and related methods for improved pretargeted radioimunotherapies
US20210069194A1 (en) * 2018-01-17 2021-03-11 Mingsight Pharmaceuticals, Inc. Combination therapy for the treatment of cancer
SG11202011589WA (en) * 2018-05-24 2020-12-30 Ayala Pharmaceuticals Inc Compositions comprising bisfluoroalkyl-1,4-benzodiazepinone compounds and immunotherapeutics and methods of use thereof
UY38251A (es) * 2018-06-01 2019-12-31 Novartis Ag Moléculas de unión contra bcma y usos de las mismas
BR112021020409A2 (pt) * 2019-04-10 2021-12-07 Glaxosmithkline Ip Dev Ltd Terapia de combinação com anticorpo anti-bcma e inibidor de gama-secretase
EP4010322B1 (en) 2019-08-09 2025-11-05 Pfizer Inc. Solid state forms of (s)-2-(((s)-6,8-difluoro-1,2,3,4-tetrahydronaphthalen-2-yl)amino)-n-(1-(2-methyl-1-(neopentylamino)propan-2-yl)-1h-imidazol-4-yl)pentanamide and uses thereof

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JP2025168430A (ja) 2025-11-07
WO2021183934A1 (en) 2021-09-16
CA3171267A1 (en) 2021-09-16
PE20230614A1 (es) 2023-04-14
MX2022011258A (es) 2023-01-11
TW202200132A (zh) 2022-01-01
JP2023517243A (ja) 2023-04-24
BR112022018251A2 (pt) 2022-11-08
CO2022014388A2 (es) 2023-02-16
CN115916188A (zh) 2023-04-04
CL2022002479A1 (es) 2023-08-18
JP7781764B2 (ja) 2025-12-08
EP4132515A1 (en) 2023-02-15
IL296075A (en) 2022-11-01
AR121566A1 (es) 2022-06-15
ZA202209989B (en) 2025-12-17
AU2021236340A1 (en) 2022-09-29
US20230121547A1 (en) 2023-04-20

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