KR20230004768A - 4'-티오-5-아자-2'-데옥시시티딘을 이용한 혈액암 치료용 조성물 및 그의 용도 - Google Patents
4'-티오-5-아자-2'-데옥시시티딘을 이용한 혈액암 치료용 조성물 및 그의 용도 Download PDFInfo
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- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2024191252A1 (ko) * | 2023-03-14 | 2024-09-19 | 주식회사 피노바이오 | 골수에 작용하는 5-아자-4'-티오-2'-데옥시사이티딘의 최고 혈중농도를 정교하게 제어가능한 경구용 제형 |
| WO2025100762A1 (ko) * | 2023-11-08 | 2025-05-15 | 한국생명공학연구원 | 4'-티오-5-아자-2'-디옥시사이티딘을 포함하는 간질환의 개선, 예방 또는 치료용 조성물 |
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| WO2019204637A1 (en) * | 2018-04-19 | 2019-10-24 | Southern Research Institute | 4'-thio-nucleotide and -nucleoside prodrugs for the treatment of cancer |
| US11938143B2 (en) | 2021-10-19 | 2024-03-26 | Akirabio, Inc. | Compositions comprising 2′-deoxycytidine analogs and use thereof for the treatment of sickle cell disease, thalassemia, and cancers |
| CN117187391B (zh) * | 2023-09-15 | 2025-03-18 | 中国医学科学院北京协和医院 | 普卡霉素在垂体促肾上腺皮质激素腺瘤中的应用 |
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| US6020322A (en) | 1993-11-09 | 2000-02-01 | Pro-Neuron, Inc. | Acyl deoxyribonucleoside derivatives and uses thereof |
| US5591722A (en) | 1989-09-15 | 1997-01-07 | Southern Research Institute | 2'-deoxy-4'-thioribonucleosides and their antiviral activity |
| CA2338415C (en) | 1998-07-23 | 2006-10-10 | Southern Research Institute | Preparation of thioarabinofuranosyl compounds and use thereof |
| WO2004018494A1 (ja) | 2002-08-22 | 2004-03-04 | Geneticlab Co., Ltd. | ４’−チオヌクレオチド |
| US20060014949A1 (en) | 2004-07-13 | 2006-01-19 | Supergen Inc. | Compositions and formulations of decitabine polymorphs and methods of use thereof |
| CN103951583B (zh) | 2006-12-06 | 2016-01-06 | 科内图斯医药公司 | 一种抑制剂的结晶形式 |
| PL3692983T3 (pl) | 2008-05-15 | 2021-12-27 | Celgene Corporation | Doustne formulacje analogów cytydyny i sposoby ich zastosowania |
| WO2011109383A1 (en) * | 2010-03-02 | 2011-09-09 | Southern Research Institute | Use of 2'-deoxy -4'-thiocytidine and its analogues as dna hypomethylating anticancer agents |
| US20110218170A1 (en) * | 2010-03-02 | 2011-09-08 | Southern Research Institute | Use of 2'-deoxy-4'-thiocytidine and its analogues as dna hypomethylating anticancer agents |
| WO2011109012A1 (en) * | 2010-03-02 | 2011-09-09 | Southern Research Institute | Use of 2'-deoxy-4'-thiocytidine and its analogues as dna hypomethylating anticancer agents |
| SG11201610551TA (en) * | 2014-07-14 | 2017-01-27 | Gilead Sciences Inc | Combinations for treating cancers |
| TWI678373B (zh) | 2014-10-31 | 2019-12-01 | 日商富士軟片股份有限公司 | 硫代核苷衍生物或其鹽及醫藥組合物 |
| CN109553651B (zh) | 2015-04-03 | 2021-08-06 | 四川科伦博泰生物医药股份有限公司 | 4’-硫代核苷的新型化合物及其制备方法、药物组合物和应用 |
| US20160312261A1 (en) | 2015-04-24 | 2016-10-27 | Plasmia Biotech, S.L. | Enzymatic production of cytosinic nucleoside analogues |
| US10815264B2 (en) | 2015-05-27 | 2020-10-27 | Southern Research Institute | Nucleotides for the treatment of cancer |
| EP3207932A1 (en) * | 2016-02-19 | 2017-08-23 | Universität Stuttgart | Dna methyltransferase inhibitors for rett syndrome therapy |
| EP3527226A4 (en) * | 2016-10-17 | 2020-06-17 | Daiichi Sankyo Company, Limited | COMBINATION THERAPY PROCEDURE WITH MDM2 INHIBITOR AND DNA METHYL TRANSFERASE INHIBITOR |
| EP3746452B1 (en) * | 2018-02-01 | 2023-09-13 | The United States of America, as represented by the Secretary, Department of Health and Human Services | Stereoselective synthesis and process for the manufacturing of 2'-deoxynucleosides |
| WO2019204637A1 (en) * | 2018-04-19 | 2019-10-24 | Southern Research Institute | 4'-thio-nucleotide and -nucleoside prodrugs for the treatment of cancer |
| EP3856754A1 (en) * | 2018-09-25 | 2021-08-04 | The United States of America, as represented by the Secretary, Department of Health and Human Services | 2'-halogenated-4'-thio-2'-deoxy-5-azacytidine analogs and use thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2024191252A1 (ko) * | 2023-03-14 | 2024-09-19 | 주식회사 피노바이오 | 골수에 작용하는 5-아자-4'-티오-2'-데옥시사이티딘의 최고 혈중농도를 정교하게 제어가능한 경구용 제형 |
| WO2025100762A1 (ko) * | 2023-11-08 | 2025-05-15 | 한국생명공학연구원 | 4'-티오-5-아자-2'-디옥시사이티딘을 포함하는 간질환의 개선, 예방 또는 치료용 조성물 |
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| AU2021260964A1 (en) | 2022-12-01 |
| JP2023524912A (ja) | 2023-06-13 |
| US20210330689A1 (en) | 2021-10-28 |
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| US12208112B2 (en) | 2025-01-28 |
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| CN115768432A (zh) | 2023-03-07 |
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