KR20230000327A - A composition for preventing finger sucking applicable to nail - Google Patents

Abstract

The present invention provides a composition for preventing finger sucking, which is applicable to nails, and includes denatonium benzoate and sorbitol. Finger sucking can be prevented more effectively by enhancing the bitter taste of the composition for preventing finger sucking, which is applicable to nails or by reducing pain while maintaining the bitter taste to a predetermined level.

Description

A composition for preventing finger sucking applicable to nail}

The present invention relates to a composition effective for preventing finger sucking, and more particularly, to a composition for preventing finger sucking applicable to a nail.

Techniques are being developed to suppress sucking of fingers by infants and toddlers. Among them, a technique for suppressing finger sucking by applying a bitter-tasting substance to the nail is known (see Korean Registered Patent Publication No. 10-1987598).

On the other hand, dinatonium benzoate is also known as a substance exhibiting a bitter taste, and the present inventors have completed the present invention as a result of studying a finger sucking prevention technology using dinatonium benzoate.

Republic of Korea Patent Registration No. 10-1987598, (2019.6.10), specification

One problem to be solved by the present invention is to provide a composition for preventing finger sucking that can be applied to nails.

The object of the present invention is not limited to the above-mentioned tasks, and other tasks not mentioned will be clearly understood by those skilled in the art from the following description.

Surprisingly, the present inventors have completed the present invention, which enhances the bitter taste or reduces pain while maintaining the bitter taste to a certain extent by combining sorbitol, which exhibits a sweet taste, with dinatonium benzoate.

Accordingly, the present invention provides a composition for preventing finger sucking applicable to a nail containing dinatonium benzoate and sorbitol.

In addition, the present invention provides a use of dinatonium benzoate and sorbitol to prevent finger sucking.

According to the present invention, it is possible to more effectively prevent finger sucking by enhancing the bitter taste of the composition for preventing finger sucking applicable to nails or reducing pain while maintaining the bitter taste to a certain extent.

Hereinafter, the advantages and features of the present invention, and methods for achieving them will become clear with reference to the embodiments described below in detail in conjunction with the accompanying drawings. However, the present invention is not limited to the embodiments disclosed below, but will be implemented in a variety of different forms, and only the present embodiments make the disclosure of the present invention complete, and common knowledge in the art to which the present invention belongs. It is provided to completely inform the holder of the scope of the invention, and the present invention is only defined by the scope of the claims.

Throughout the specification, “and/or” includes each and every combination of one or more of the recited elements.

Terminology used herein is for describing the embodiments and is not intended to limit the present invention. In this specification, singular forms also include plural forms unless specifically stated otherwise in a phrase. As used herein, “comprises” and/or “comprising” does not preclude the presence or addition of one or more other components and/or steps in which a stated component and/or step is present.

In the present specification, 'nail' preferably means a fingernail, and 'finger sucking' means a state in which at least a part of a finger enters or can enter the oral cavity. Accordingly, 'finger sucking' encompasses a state in which at least a part of a finger inevitably enters or can enter the oral cavity, such as 'nail biting'.

A composition for preventing finger sucking applicable to a nail according to an embodiment of the present invention includes denatonium benzoate and sorbitol.

In one embodiment of the present invention, by combining sorbitol, which represents a sweet taste, with dinatonium benzoate, which represents a bitter taste, the bitter taste is strengthened or the pain is reduced while maintaining the bitter taste to a certain extent, thereby preventing finger sucking more effectively. Do. Therefore, one embodiment of the present invention includes dinatonium benzoate and sorbitol as active ingredients. The active ingredient means a component that exhibits a finger sucking prevention effect. Preferably, it may be 400,000 to 800,000 parts by weight of sorbitol based on 100 parts by weight of dinatonium benzoate. Within this range, the effect of enhancing bitterness and/or reducing pain is excellent, and below or exceeding this range, there is a concern that the effect of enhancing bitterness and/or reducing pain may be insufficient. In addition, the volatility is excellent in such a range, and there is a concern that the volatility may be reduced beyond such a range. More preferably, sorbitol may be 500,000 to 800,000 parts by weight, and even more preferably 500,000 to 600,000 parts by weight, based on 100 parts by weight of dinatonium benzoate. In this range, not only the effect of enhancing the bitter taste and/or the effect of reducing pain is excellent, but also excellent in terms of volatility and moisturizing properties. Below that range, there is a fear that the moisturizing action will be insufficient, and above that range, there is a fear that stickiness will increase due to lack of volatility. More preferably, it may be 600,000 parts by weight of sorbitol based on 100 parts by weight of dinatonium benzoate. At this ratio, it is excellent in terms of bitterness enhancing effect and/or pain reducing effect, volatility, and moisturizing properties. At this time, the 'bitter taste enhancement effect' means that the strength of the bitter taste is increased, and may include selectively reducing pain in the tongue. That is, the strength of the bitter taste itself can be increased by reducing the pain. In such a case, the pain caused by pain is avoided, and the hand-sucking behavior can be more effectively suppressed mainly by the bitter taste.

In addition, one embodiment of the present invention may further include a viscosity enhancing agent. By such a viscosity increasing agent, the coating surface can be more easily formed during nail application. The viscosity increasing agent may be, for example, Xanthan Gum. Preferably, xanthan gum may be 800 to 1500 parts by weight based on 100 parts by weight of dinatonium benzoate. In this range, the viscosity is appropriate and the drying property is good, which is preferable in terms of film formation. More preferably, 1000 parts by weight of xanthan gum may be used with respect to 100 parts by weight of dinatonium benzoate. At this ratio, viscosity and volatilization are excellent, so nail application is smooth.

In addition, one embodiment of the present invention may further include a skin conditioning agent. The skin conditioning agent may be, for example, Hydrolyzed Keratin. With such a skin conditioning agent, it is possible to maintain a more healthy state of nails. Preferably, the hydrolyzed keratin may be 10000 to 100000 parts by weight based on 100 parts by weight of dinatonium benzoate. More preferably, it may be 20000 parts by weight of hydrolyzed keratin based on 100 parts by weight of dinatonium benzoate.

In addition, one embodiment of the present invention may further include a preservative. The antiseptic agent can increase the preservability of the composition for preventing finger sucking. Preservatives may include antioxidants. The antioxidant may be, for example, hydroxyacetophenone. Based on 100 parts by weight of dinatonium benzoate, preferably 200 to 400 parts by weight of hydroxyacetopinone, more preferably 260 to 360 parts by weight of hydroxyacetopinone. More preferably, it may be 320 parts by weight of hydroxyacetopinone based on 100 parts by weight of dinatonium benzoate. At this ratio, the preservation effect is more excellent.

In addition, one embodiment of the present invention may further include a moisturizer. The humectant may be, for example, at least one selected from butylene glycol, caprylyl glycol, and pentylene glycol. Preferably, based on 100 parts by weight of dinatonium benzoate, butylene glycol may be 8000 to 16000 parts by weight, caprylyl glycol 900 to 1800 parts by weight, and pentylene glycol 900 to 1800 parts by weight. More preferably, 11200 parts by weight of butylene glycol, 1440 parts by weight of caprylyl glycol, and 1440 parts by weight of pentylene glycol may be used based on 100 parts by weight of dinatonium benzoate. In this range, the moisturizing power is more excellent.

In addition, one embodiment of the present invention may further include a solvent. The solvent may be a hydrophilic solvent. Specifically, the solvent may be water and/or alcohol. Preferably, based on 100 parts by weight of dinatonium benzoate, the solvent may be 1,000,000 to 3,000,000 parts by weight, more preferably, 1,200,000 to 2,000,000 parts by weight. Even more preferably, based on 100 parts by weight of dinatonium benzoate, the solvent may be 1,300,000 to 2,000,000 parts by weight. In this range, the pain in the tongue can be suppressed while giving a relatively bitter taste. Above this range, there is a concern that the bitter taste effect may be insufficient, and below this range, there is a fear that the tongue may be excessively painful.

One embodiment of the present invention may be a cosmetic composition. The cosmetic composition may further include cosmetically acceptable additives. Additives that can be added to cosmetic compositions may include ingredients commonly used in cosmetic compositions, and include, for example, stabilizers, solubilizers, vitamins, pigments, and/or perfumes, and conventional adjuvants and carriers. In addition, additives that can be added to the cosmetic composition include oil and fat components, humectants, emollients, surfactants, organic and inorganic pigments, organic powders, preservatives, bactericides, antioxidants, pH adjusters, alcohols, pigments, and / or fragrances, etc. can be heard

In addition, one embodiment of the present invention may be a pharmaceutical composition. The pharmaceutical composition may be formulated in the form of an agent for preventing finger sucking, an agent for preventing nail biting, or an agent for preventing nail biting. Additives that can be added to the pharmaceutical composition for formulation may include a pharmaceutically acceptable carrier. When formulating, commonly used fillers, extenders, binders, wetting agents, surfactants, diluents or excipients may be used. In addition, conventional adjuvants such as stabilizers, solubilizers, and/or vitamins may be included. In addition, additives that can be added to the pharmaceutical composition include oil and fat components, moisturizing agents, surfactants, preservatives, bactericides, antioxidants, and/or pH adjusters.

Another embodiment of the present invention is the use of dinatonium benzoate and sorbitol to prevent finger sucking. Finger sucking includes nail biting.

Another embodiment of the present invention may be a pharmaceutical composition for preventing finger sucking comprising dinatonium benzoate and sorbitol as active ingredients. The pharmaceutical composition is applicable to the nail.

In addition, another embodiment of the present invention may be a cosmetic composition for preventing finger sucking comprising dinatonium benzoate and sorbitol as active ingredients. The cosmetic composition is applicable to nails.

Further, another embodiment of the present invention may be a method for preventing finger sucking comprising administering dinatonium benzoate and sorbitol to an animal (including human or non-human animal). Such animals may be mammals. Also, such animals may be animals in need of administration of dinatonium benzoate and sorbitol. Further, such an animal may be an animal that develops or is likely to develop finger sucking. At this time, the administered dinatonium benzoate and sorbitol may be effective amounts of dinatonium benzoate and sorbitol.

In addition, another embodiment of the present invention may be a use of dinatonium benzoate and sorbitol for preparing a preparation for preventing finger sucking.

Unless otherwise stated, the pharmaceutical composition, cosmetic composition, method, and use of the present invention are applied equally unless contradictory to each other.

Dinatonium benzoate and sorbitol may be formulated by adding pharmaceutically or food-acceptable additives such as carriers, excipients, or diluents, and for formulation, reference may be made to widely known literature in the relevant field.

Therefore, the composition of one embodiment of the present invention further includes a pharmaceutically acceptable additive or cosmetically acceptable additive, and includes a pharmaceutically acceptable additive or cosmetically acceptable additive to dinatonium benzoate and sorbitol. It can be done by adding Such a composition may contain 0.01 to 99.99% by weight of dinatonium benzoate and sorbitol.

Dinatonium benzoate and sorbitol included in the composition or used in the use or method of one embodiment of the present invention can be used in a dose of 1 to 30 mg per day based on an adult (60 kg). It can be administered to a subject by applying dinatonium benzoate and sorbitol to the nail, and can be administered once a day or divided into several times. However, the scope of the present invention is not limited by the dosage and frequency of administration.

Hereinafter, examples of the present invention will be described in more detail with reference to experimental examples and formulation examples. As for the reagents used in the experimental examples, the highest grade available on the market was used, and those purchased from Sigma and the like were used.

<Experimental Example 1> Bitter taste evaluation experiment

After applying the samples in Table 1 to the nails, a bitter taste evaluation experiment was conducted. With a maximum of 10 points, the intensity of bitterness and pain intensity of each sample were evaluated. Each sample was prepared by mixing the components listed in Table 1 into purified water (remaining amount). The results are shown in Table 1. In Table 1, the higher the score, the stronger the strength.

sample Dinatonium Benzoate
(weight%) Sorbitol
(weight%) bitter taste intensity pain intensity One 0.003 - 4 8 2 0.005 - 8 9 3 0.01 - 10 10 4 0.005 20 9 9 5 0.005 25 9 8 6 0.005 27 8 8 7 0.005 30 8 7 8 0.005 40 7 7 9 0.005 50 3 6

Sample 1 (100 parts by weight of dinatonium benzoate, 3,333,233 parts by weight of solvent) did not have strong bitterness, and sample 3 (100 parts by weight of dinatonium benzoate, 999,900 parts by weight of solvent) had bitterness is strong, but the pain intensity is also strong. In the case of sample 2 (1,999,900 parts by weight of solvent with respect to 100 parts by weight of dinatonium benzoate), the intensity of bitterness was strong and the intensity of pain was relatively weak. Therefore, considering both bitter taste and pain, it can be seen that the content of 1,000,000 to 3,000,000 parts by weight of the solvent is more preferable with respect to 100 parts by weight of dinatonium benzoate in the composition for preventing finger sucking.

In addition, sample 4 (sample corresponding to 400,000 parts by weight of sorbitol based on 100 parts by weight of dinatonium benzoate), sample 5 (sample corresponding to 500,000 parts by weight of sorbitol based on 100 parts by weight of dinatonium benzoate), sample 6 (dinatonium benzoate) 540,000 parts by weight of sorbitol for 100 parts by weight of tonium benzoate), sample 7 (relative to 100 parts by weight of dinatonium benzoate, 600,000 parts by weight of sorbitol), and sample 8 (100 parts by weight of dinatonium benzoate) 800,000 parts by weight of sorbitol) showed favorable results in terms of bitterness and pain intensity. That is, compared to Sample 2 to which the same content of dinatonium benzoate was applied, Sample 4 was found to enhance bitter taste, Sample 5 was found to enhance bitter taste and reduce pain, and Sample 6 was found to enhance bitter taste. It was found to maintain the bitter taste and reduce the pain, Sample 7 maintained the bitter taste and reduced the pain more, and Sample 8 showed that the pain was reduced while maintaining the bitter taste to a certain extent. In the case of sample 9 (100 parts by weight of dinatonium benzoate, 1 million parts by weight of sorbitol), the bitterness was relatively low. Therefore, considering the bitter taste and pain together, the content of sorbitol is preferably 400,000 to 800,000 parts by weight, and the content of 400,000 to 600,000 parts by weight is more preferable with respect to 100 parts by weight of dinatonium benzoate in the composition for preventing finger sucking. can know

In addition, through such experiments, it was confirmed clinically that the present invention can effectively prevent finger sucking when applied to nails.

<Experimental Example 2> Volatility test

With respect to the samples prepared in the same way as Samples 5 to 10 of Experimental Example 1, the time required until volatilization was completed was measured. The results are shown in Table 2.

sample Dinatonium Benzoate
(weight%) Sorbitol
(weight%) volatility
{time (seconds)} 4 0.005 20 10 5 0.005 25 12 6 0.005 27 15 7 0.005 30 20 8 0.005 40 40 9 0.005 50 60

As shown in Table 2, sample 4 (sample corresponding to 400,000 parts by weight of sorbitol based on 100 parts by weight of dinatonium benzoate), sample 5 (sample corresponding to 500,000 parts by weight of sorbitol based on 100 parts by weight of dinatonium benzoate), Sample 6 (based on 100 parts by weight of dinatonium benzoate, 540,000 parts by weight of sorbitol), Sample 7 (based on 100 parts by weight of dinatonium benzoate, 600,000 parts by weight of sorbitol), and sample 8 (dinatonium benzoate) 800,000 parts by weight of sorbitol relative to 100 parts by weight of benzoate) showed favorable results in terms of volatility. In the case of sample 9 (100 parts by weight of dinatonium benzoate, 1 million parts by weight of sorbitol), the volatility was found to be relatively low. Therefore, considering volatility, it can be seen that the content of 400,000 to 800,000 parts by weight of sorbitol is more preferable with respect to 100 parts by weight of dinatonium benzoate in the composition for preventing finger sucking.

<Experimental Example 3> Moisture test

It was prepared in the same way as Samples 4 to 9 of Experimental Example 1, and after applying each sample to the skin, the moisturizing power was measured with a skin analyzer (KRD1042, manufacturer: belulu). The results are shown in Table 3.

sample Dinatonium Benzoate
(weight%) Sorbitol
(weight%) moisturizing power
(%) 4 0.005 20 72 5 0.005 25 78 6 0.005 27 80 7 0.005 30 85 8 0.005 40 87 9 0.005 50 88

As shown in Table 3, sample 5 (sample corresponding to 500,000 parts by weight of sorbitol based on 100 parts by weight of dinatonium benzoate), sample 6 (sample corresponding to 540,000 parts by weight of sorbitol based on 100 parts by weight of dinatonium benzoate), Sample 7 (with respect to 100 parts by weight of dinatonium benzoate, 600,000 parts by weight of sorbitol) and sample 8 (with respect to 100 parts by weight of dinatonium benzoate, 800,000 parts by weight of sorbitol) are preferred results in terms of moisturizing power showed

Sample 4 (a sample corresponding to 400,000 parts by weight of sorbitol with respect to 100 parts by weight of dinatonium benzoate) was found to have relatively insufficient moisturizing power, which seems to be due to the relatively low content of sorbitol.

Considering the results of Experimental Examples 1 to 3, sorbitol is preferably 400,000 to 800,000 parts by weight based on 100 parts by weight of dinatonium benzoate in terms of bitterness enhancing effect and / or pain reducing effect, and volatility, and moisturizing properties are also considered It can be seen that relative to 100 parts by weight of dinatonium benzoate, 500,000 to 800,000 parts by weight of sorbitol is more preferable, and 500,000 to 600,000 parts by weight is more preferable. In particular, with respect to 100 parts by weight of dinatonium benzoate, in the content of 600,000 parts by weight of sorbitol, it can be seen that the effect of enhancing bitterness and / or reducing pain, volatility, moisturizing properties, etc. are excellent. Considering these results, subsequent experiments were conducted based on the content of 600,000 parts by weight of sorbitol based on 100 parts by weight of dinatonium benzoate.

<Experimental Example 4> Viscosity enhancing agent effect test

4-1. viscosity experiment

As shown in Table 4, samples having different viscosity enhancing agent contents were prepared, and the viscosity of each sample was measured with a viscometer (rotary viscometer, 25° C.). Each sample was prepared by mixing the components listed in Table 4 into purified water (remaining amount). The results are shown in Table 4.

sample Dinatonium Benzoate
(weight%) Sorbitol
(weight%) xanthan gum
(weight%) viscosity
(CPS) 10 0.005 30 0.03 10 11 0.005 30 0.05 20 12 0.005 30 0.1 50

As shown in the table, sample 11 (sample corresponding to 1000 parts by weight of xanthan gum based on 100 parts by weight of dinatonium benzoate) and sample 12 (sample corresponding to 2000 parts by weight of xanthan gum based on 100 parts by weight of dinatonium benzoate) Viscosity was found to be more favorable. Sample 10 (600 parts by weight of xanthan gum relative to 100 parts by weight of dinatonium benzoate) was found to be in a relatively dilute state.

4-2. volatility experiment

As shown in Table 5, samples having different viscosity enhancing agent contents were prepared, and the time required for each sample until volatilization was completed was measured. Each sample was prepared by mixing the components listed in Table 5 into purified water (remaining amount). The results are shown in Table 5.

sample Dinatonium Benzoate
(weight%) Sorbitol
(weight%) xanthan gum
(weight%) volatility
{time (seconds)} 10 0.005 30 0.03 25 11 0.005 30 0.05 28 12 0.005 30 0.1 35

As shown in the table, sample 10 (sample corresponding to 600 parts by weight of xanthan gum based on 100 parts by weight of dinatonium benzoate) and sample 11 (sample corresponding to 1000 parts by weight of xanthan gum based on 100 parts by weight of dinatonium benzoate) It can be seen that the film can be formed in a short time due to the excellent volatility. Sample 12 (2000 parts by weight of xanthan gum relative to 100 parts by weight of dinatonium benzoate) showed relatively low volatility.

From the above experimental results, it can be seen that the content of xanthan gum is preferably 800 to 1500 parts by weight with respect to 100 parts by weight of dinatonium benzoate in the composition for preventing finger sucking, considering both volatility and viscosity. That is, in this ratio, it can be seen that the viscosity and volatility are excellent, and the coating surface is formed more smoothly.

<Experimental Example 5> Antiseptic test

As shown in Table 6, samples with different contents were prepared and tested for preservative power (Ministry of Food and Drug Safety Notice No. 2019-27 Regulations on Cosmetics Safety Criteria, etc. Annex 4 Microbial Limit Items in Liquid Cosmetics Safety Management Test Methods) Reference). Each sample was prepared by mixing the components listed in Table 6 into purified water (remaining amount). The results are shown in Table 6.

sample 13 14 15 Dinatonium Benzoate
(weight%) 0.005 0.005 0.005 Sorbitol
(weight%) 30 30 30 xanthan gum
(weight%) 0.03 0.05 0.05 hydrolyzed keratin
(weight%) One One One Butylene Glycol
(weight%) 0.4 0.56 0.8 caprylyl glycol
(weight%) 0.045 0.072 0.09 pentylene glycol
(weight%) 0.045 0.072 0.09 Hydroxyacetophenone
(weight%) 0.01 0.016 0.02 antiseptic power fitness fitness fitness

As shown in the table, sample 13 (relative to 100 parts by weight of dinatonium benzoate, 200 parts by weight of hydroxyacetophenone corresponding sample), sample 14 (relative to 100 parts by weight of dinatonium benzoate, 320 parts by weight of hydroxyacetophenone This sample) and Sample 15 (400 parts by weight of hydroxyacetophenone with respect to 100 parts by weight of dinatonium benzoate) were all found to have adequate preservative power.

From the above results, it can be seen that in one embodiment of the present invention, by combining sorbitol, which exhibits a sweet taste, with dinatonium benzoate, which exhibits a bitter taste, the bitter taste is rather strengthened, and finger sucking can be prevented more effectively. In addition, it can be seen that one embodiment of the present invention not only has an excellent bitter taste enhancing effect, but also excellent properties such as volatility and moisture retention, so that it is easy to apply to nails and also exhibits an effect of protecting nails.

<Preparation Example 1> Preparation of a composition for preventing finger sucking

With the ingredients and compositions shown in Table 7, a composition for preventing finger sucking was prepared. Specifically, a composition was prepared by mixing the components of Table 7 with purified water (remaining amount), and the prepared composition was filled in a manicure container (10ml) or a pencil-type cosmetic container (3ml).

manufacturing example One Dinatonium Benzoate
(weight%) 0.005 Sorbitol
(weight%) 30 xanthan gum
(weight%) 0.05 hydrolyzed keratin
(weight%) One Butylene Glycol
(weight%) 0.56 caprylyl glycol
(weight%) 0.072 pentylene glycol
(weight%) 0.072 Hydroxyacetophenone
(weight%) 0.016

Claims (5)

A composition for preventing finger sucking applicable to a nail comprising dinatonium benzoate and sorbitol. The composition for preventing finger sucking applicable to nails according to claim 1, wherein the sorbitol is 400,000 to 800,000 parts by weight based on 100 parts by weight of the dinatonium benzoate. The composition for preventing finger sucking applicable to a nail according to claim 1, further comprising a viscosity enhancing agent. The composition for preventing finger sucking according to claim 1, which is a cosmetic composition applicable to a nail. The composition for preventing finger sucking according to claim 1, which is applicable to a nail and is a pharmaceutical composition.