WO2024090589A1 - Composition for preventing finger sucking, applicable to nails - Google Patents

Abstract

The present invention provides a composition for preventing finger sucking, the composition being applicable to nails and comprising denatonium benzoate and sorbitol. According to the present invention, the bitter taste of the composition which is for preventing finger sucking and applicable to nails can be increased or can be maintained to a certain extent while reducing pain to more effectively prevent finger sucking.

Description

Composition for preventing finger sucking applicable to nails

The present invention relates to a composition effective in preventing finger sucking, and more specifically, to a composition for preventing finger sucking that can be applied to nails.

Technology is being developed primarily to suppress finger sucking in infants and young children. Among them, a technique for suppressing finger sucking by applying a bitter-tasting substance to the nails is known (see Korean Patent Publication No. 10-1987598).

Meanwhile, dinatonium benzoate is also known as a substance that exhibits a bitter taste, and the present inventors completed the present invention as a result of researching technology to prevent finger sucking using denatonium benzoate.

[Prior art literature]

[Patent Document]

(Patent Document 1) Republic of Korea Patent Publication No. 10-1987598, (June 10, 2019), Specification

One problem that the present invention aims to solve is to provide a composition for preventing finger sucking that can be applied to nails in order to prevent finger sucking.

The object of the present invention is not limited to the problem mentioned above, and other problems not mentioned will be clearly understood by those skilled in the art from the description below.

Surprisingly, the present inventor has completed the present invention, which reduces pain while enhancing the bitter taste or maintaining the bitter taste to a certain degree by combining sorbitol, which has a sweet taste, with denatonium benzoate.

Accordingly, the present invention provides a composition for preventing finger sucking applicable to nails containing denatonium benzoate and sorbitol.

Additionally, the present invention provides a use of denatonium benzoate and sorbitol to prevent finger sucking.

According to the present invention, finger sucking can be prevented more effectively by enhancing the bitter taste of the composition for preventing finger sucking applicable to nails or reducing pain while maintaining the bitter taste to a certain degree.

Hereinafter, the advantages and features of the present invention and methods for achieving them will become clear with reference to the embodiments described in detail below along with the accompanying drawings. However, the present invention is not limited to the embodiments disclosed below and will be implemented in various different forms. These embodiments only serve to ensure that the disclosure of the present invention is complete and that common knowledge in the technical field to which the present invention pertains is not limited. It is provided to fully inform those who have the scope of the invention, and the present invention is only defined by the scope of the claims.

Throughout the specification, “and/or” includes each and every combination of one or more of the mentioned elements.

The terminology used herein is for describing embodiments and is not intended to limit the invention. As used herein, singular forms also include plural forms, unless specifically stated otherwise in the context. As used in the specification, “comprises” and/or “comprising” does not exclude the presence or addition of one or more other components and/or steps.

In this specification, 'nail' preferably refers to fingernails, and 'finger sucking' refers to a state in which at least part of the finger enters or can enter the oral cavity. Therefore, 'finger sucking', like 'nail biting', encompasses a condition in which at least part of the finger inevitably enters or may enter the oral cavity.

The composition for preventing finger sucking applicable to nails according to an embodiment of the present invention includes denatonium benzoate and sorbitol.

One embodiment of the present invention combines denatonium benzoate, which has a bitter taste, with sorbitol, which has a sweet taste, thereby enhancing the bitter taste or reducing pain while maintaining the bitter taste to a certain degree, thereby preventing finger sucking more effectively. do. Accordingly, one embodiment of the present invention includes denatonium benzoate and sorbitol as active ingredients. Active ingredients refer to ingredients that have an anti-sucking effect. Preferably, sorbitol may be 400,000 to 800,000 parts by weight based on 100 parts by weight of denatonium benzoate. Within this range, the bitter taste enhancing effect and/or pain reducing effect are excellent, and below or exceeding the same range, there is a risk that the bitter taste enhancing effect and/or pain reducing effect may be insufficient. In addition, volatility is excellent within this range, and there is a risk that volatility may decrease beyond this range. More preferably, it may be 500,000 to 800,000 parts by weight of sorbitol, and even more preferably 500,000 to 600,000 parts by weight, based on 100 parts by weight of dinatonium benzoate. In this range, not only is the bitter taste enhancing effect and/or pain reducing effect excellent, but it is also excellent in terms of volatility and moisturizing properties. If it is below that range, there is a risk that the moisturizing effect may be insufficient, and if it exceeds the range, there is a risk that stickiness may increase due to insufficient volatility. More preferably, it may be 600,000 parts by weight of sorbitol based on 100 parts by weight of denatonium benzoate. At this ratio, it is excellent in terms of bitter taste enhancing effect and/or pain reducing effect, volatility, and moisturizing properties. At this time, the 'bitter taste enhancing effect' means increasing the intensity of the bitter taste, and may optionally include reducing pain on the tongue. In other words, the intensity of the bitter taste itself can be increased by reducing pain. In such cases, pain due to pain is avoided, and hand-sucking behavior can be more effectively suppressed mainly by bitter taste.

Additionally, an embodiment of the present invention may further include a viscosity enhancing agent. By using such a viscosity increasing agent, the coated surface can be formed more easily when applying nails. The viscosity increasing agent may be, for example, Xanthan Gum. Preferably, xanthan gum may be 800 to 1,500 parts by weight based on 100 parts by weight of denatonium benzoate. In this range, the viscosity is appropriate, drying properties are good, and it is desirable in terms of film formation. More preferably, it may be 1000 parts by weight of xanthan gum based on 100 parts by weight of dinathonium benzoate. At this ratio, viscosity and volatility are excellent, making nail application smooth.

Additionally, an embodiment of the present invention may further include a skin conditioning agent. The skin conditioning agent may be, for example, Hydrolyzed Keratin. With such a skin conditioning agent, nails can be maintained in a healthier state. Preferably, the amount of hydrolyzed keratin may be 10,000 to 100,000 parts by weight based on 100 parts by weight of dinatonium benzoate. More preferably, it may be 20,000 parts by weight of hydrolyzed keratin based on 100 parts by weight of dinatonium benzoate.

Additionally, an embodiment of the present invention may further include a preservative. Preservatives can increase the preservability of the composition for preventing finger sucking. Preservatives may include antioxidants. The antioxidant may be, for example, Hydroxyacetophenone. Based on 100 parts by weight of dinatonium benzoate, preferably 200 to 400 parts by weight of hydroxyacetopinone, more preferably 260 to 360 parts by weight of hydroxyacetopinone. More preferably, it may be 320 parts by weight of hydroxyacetopinone based on 100 parts by weight of dinatonium benzoate. At this ratio, the preservation effect is more excellent.

Additionally, an embodiment of the present invention may further include a moisturizer. The humectant may be, for example, one or more selected from Butylene Glycol, Caprylyl Glycol, and Pentylene Glycol. Preferably, it may be 8000 to 16000 parts by weight of butylene glycol, 900 to 1800 parts by weight of caprylyl glycol, and 900 to 1800 parts by weight of pentylene glycol, based on 100 parts by weight of dinatonium benzoate. More preferably, it may be 11,200 parts by weight of butylene glycol, 1,440 parts by weight of caprylyl glycol, and 1,440 parts by weight of pentylene glycol, based on 100 parts by weight of dinatonium benzoate. In this range, the moisturizing power is more excellent.

Additionally, an embodiment of the present invention may further include a solvent. The solvent may be a hydrophilic solvent. Specifically, the solvent may be water and/or alcohol. Preferably, based on 100 parts by weight of dinatonium benzoate, the solvent may be 1,000,000 to 3,000,000 parts by weight, more preferably 1,200,000 to 2,000,000 parts by weight. Even more preferably, the solvent may be 1,300,000 to 2,000,000 parts by weight based on 100 parts by weight of dinatonium benzoate. In this range, a relatively bitter taste can be produced while pain in the tongue can be suppressed. If it exceeds this range, the bitter taste effect may be insufficient, and if it falls below this range, there may be excessive pain in the tongue.

One embodiment of the present invention may be a cosmetic composition. The cosmetic composition may further include additives acceptable for cosmetics. Additives that can be added to cosmetic compositions may include ingredients commonly used in cosmetic compositions, and include, for example, conventional auxiliaries and carriers such as stabilizers, solubilizers, vitamins, pigments and/or fragrances. Additionally, additives that can be added to cosmetic compositions include fat ingredients, moisturizers, emollients, surfactants, organic and inorganic pigments, organic powders, preservatives, disinfectants, antioxidants, pH adjusters, alcohol, colorants, and/or fragrances. can be mentioned.

Additionally, one embodiment of the present invention may be a pharmaceutical composition. The pharmaceutical composition may be formulated in the form of an anti-sucking agent, an anti-nail biting agent, or an anti-nail biting agent. Additives that can be added to pharmaceutical compositions for formulation may include pharmaceutically acceptable carriers. When formulating, commonly used fillers, extenders, binders, wetting agents, surfactants, diluents or excipients can be used. Additionally, conventional adjuvants such as stabilizers, solubilizers, and/or vitamins may be included. Additionally, additives that can be added to the pharmaceutical composition include fat ingredients, moisturizers, surfactants, preservatives, disinfectants, antioxidants, and/or pH adjusters.

In addition, another embodiment of the present invention is the use of denatonium benzoate and sorbitol to prevent finger sucking. Thumb sucking includes nail biting.

Another embodiment of the present invention may be a pharmaceutical composition for preventing finger sucking containing denatonium benzoate and sorbitol as active ingredients. The pharmaceutical composition is applicable to nails.

Additionally, another embodiment of the present invention may be a cosmetic composition for preventing finger sucking containing denatonium benzoate and sorbitol as active ingredients. The cosmetic composition is applicable to nails.

In addition, another embodiment of the present invention may be a method for preventing finger sucking, including the step of administering denatonium benzoate and sorbitol to animals (animals including humans or animals excluding humans). Such animals may be mammals. Additionally, such animals may be those requiring administration of denatonium benzoate, and sorbitol. Additionally, such animals may be those that develop or are likely to develop thumb sucking. At this time, the administered dinatonium benzoate and sorbitol may be effective amounts of denatonium benzoate and sorbitol.

In addition, another embodiment of the present invention may be used for the production of an agent for preventing finger sucking using denatonium benzoate and sorbitol.

Unless otherwise stated, matters mentioned in the pharmaceutical composition, cosmetic composition, method, and use of the present invention apply equally to each other unless they contradict each other.

Dinatonium benzoate and sorbitol can be formulated by adding additives such as pharmaceutically or foodologically acceptable carriers, excipients, or diluents, and information on formulation can be referred to literature widely known in the field.

Therefore, the composition, which is an embodiment of the present invention, further includes a pharmaceutically acceptable additive or a cosmetically acceptable additive, and includes a pharmaceutically acceptable additive or a cosmetically acceptable additive to dinatonium benzoate and sorbitol. This can be achieved by adding . Such a composition may contain 0.01 to 99.99% by weight of denatonium benzoate and sorbitol.

Dinatonium benzoate and sorbitol contained in the composition, which is an embodiment of the present invention, or used in the purpose or method, can be used in a dosage of 1 to 30 mg per day for an adult (60 kg). It can be administered to the subject by applying denatonium benzoate and sorbitol to the fingernails, and can be administered once a day or in several divided doses. However, the scope of the present invention is not limited by the above dosage and frequency of administration.

Hereinafter, embodiments of the present invention will be described in more detail with reference to experimental examples and formulation examples. The reagents used in the experimental example were of the highest quality available on the market, and those purchased from Sigma, etc. were used.

<Experimental Example 1> Bitterness evaluation experiment

After applying the samples in Table 1 to the nails, a bitter taste evaluation experiment was conducted. The bitterness intensity and pain intensity of each sample were evaluated, with a maximum score of 10 points. Each sample was prepared by mixing the ingredients listed in Table 1 in purified water (remaining amount). The results are shown in Table 1. In Table 1, the larger the score, the stronger the intensity.

sample	Dinatonium Benzoate (weight%)	Sorbitol (weight%)	bitterness intensity	Pain intensity
One	0.003	-	4	8
2	0.005	-	8	9
3	0.01	-	10	10
4	0.005	20	9	9
5	0.005	25	9	8
6	0.005	27	8	8
7	0.005	30	8	7
8	0.005	40	7	7
9	0.005	50	3	6

Sample 1 (a sample containing 3,333,233 parts by weight of solvent based on 100 parts by weight of dinatonium benzoate) does not have a strong bitter taste intensity, and Sample 3 (a sample containing 999,900 parts by weight of solvent based on 100 parts by weight of dinatonium benzoate) has a bitter taste intensity. It can be seen that the pain intensity is also strong. In the case of Sample 2 (a sample containing 1,999,900 parts by weight of solvent relative to 100 parts by weight of dinatonium benzoate), the bitter taste intensity was strong and the pain intensity was relatively weak. Therefore, considering both bitterness and pain, it can be seen that the content of 1,000,000 to 3,000,000 parts by weight of solvent is more preferable based on 100 parts by weight of dinatonium benzoate in the composition for preventing finger sucking.

In addition, Sample 4 (a sample containing 400,000 parts by weight of sorbitol based on 100 parts by weight of dinatonium benzoate), Sample 5 (a sample containing 500,000 parts by weight of sorbitol based on 100 parts by weight of dinatonium benzoate), and Sample 6 (sample containing 500,000 parts by weight of sorbitol based on 100 parts by weight of dinatonium benzoate) Sample 7 (a sample containing 540,000 parts by weight of sorbitol, based on 100 parts by weight of thonium benzoate), Sample 7 (a sample containing 600,000 parts by weight of sorbitol, based on 100 parts by weight of denatonium benzoate), and Sample 8 (100 parts by weight of denatonium benzoate) sorbitol (800,000 parts by weight sample) showed desirable results in terms of bitterness intensity and pain intensity. That is, compared to Sample 2 with the same amount of denatonium benzoate, Sample 4 was found to enhance the bitter taste, Sample 5 was shown to enhance the bitter taste and reduce pain, and Sample 6 was found to enhance the bitter taste. It was shown to maintain the bitter taste and reduce the pain, Sample 7 was shown to maintain the bitter taste and reduce the pain, and Sample 8 was shown to reduce the pain while maintaining the bitter taste to a certain degree. In the case of Sample 9 (a sample containing 1 million parts by weight of sorbitol relative to 100 parts by weight of dinatonium benzoate), the bitterness intensity was found to be relatively low. Therefore, considering bitterness and pain together, the content of sorbitol is preferably 400,000 to 800,000 parts by weight, and 400,000 to 600,000 parts by weight is more preferable, based on 100 parts by weight of dinatonium benzoate in the composition for preventing finger sucking. can be seen.

In addition, through this experiment, it was clinically confirmed that the present invention can be applied to fingernails and effectively prevent finger sucking.

<Experimental Example 2> Volatility experiment

For the samples prepared in the same way as Samples 4 to 9 of Experimental Example 1, the time required until the end of volatilization was measured. The results are shown in Table 2.

sample	Dinatonium Benzoate (weight%)	Sorbitol (weight%)	volatility {time (seconds)}
4	0.005	20	10
5	0.005	25	12
6	0.005	27	15
7	0.005	30	20
8	0.005	40	40
9	0.005	50	60

As in Table 2, Sample 4 (sample containing 400,000 parts by weight of sorbitol based on 100 parts by weight of dinatonium benzoate), Sample 5 (sample containing 500,000 parts by weight of sorbitol based on 100 parts by weight of dinatonium benzoate), Sample 6 (a sample containing 540,000 parts by weight of sorbitol, based on 100 parts by weight of dinatonium benzoate), Sample 7 (a sample containing 600,000 parts by weight of sorbitol, based on 100 parts by weight of dinatonium benzoate), and Sample 8 (sample containing 600,000 parts by weight of sorbitol, based on 100 parts by weight of dinatonium benzoate). The sample (800,000 parts by weight of sorbitol per 100 parts by weight of benzoate) showed desirable results in terms of volatility. Sample 9 (a sample containing 1 million parts by weight of sorbitol relative to 100 parts by weight of dinathonium benzoate) was found to have relatively low volatility. Therefore, considering volatility, it can be seen that a content of 400,000 to 800,000 parts by weight of sorbitol per 100 parts by weight of denatonium benzoate in the anti-sucking composition is more preferable.

<Experimental Example 3> Moisturizing power experiment

It was prepared in the same manner as Samples 4 to 9 of Experimental Example 1, and each sample was applied to the skin and then the moisturizing power was measured using a skin meter (KRD1042, manufacturer: belulu). The results are shown in Table 3.

sample	Dinatonium Benzoate (weight%)	Sorbitol (weight%)	Moisturizing power (%)
4	0.005	20	72
5	0.005	25	78
6	0.005	27	80
7	0.005	30	85
8	0.005	40	87
9	0.005	50	88

As in Table 3, Sample 5 (sample containing 500,000 parts by weight of sorbitol based on 100 parts by weight of dinatonium benzoate), Sample 6 (sample containing 540,000 parts by weight of sorbitol based on 100 parts by weight of dinatonium benzoate), Sample 7 (a sample containing 600,000 parts by weight of sorbitol based on 100 parts by weight of dinatonium benzoate) and Sample 8 (a sample containing 800,000 parts by weight of sorbitol based on 100 parts by weight of dinatonium benzoate) showed desirable results in terms of moisturizing power. indicated.

Sample 4 (a sample containing 400,000 parts by weight of sorbitol relative to 100 parts by weight of dinatonium benzoate) was found to have relatively poor moisturizing power, which appears to be due to the relatively low sorbitol content.

Considering the results of Experimental Examples 1 to 3, 400,000 to 800,000 parts by weight of sorbitol is preferable for 100 parts by weight of denatonium benzoate in terms of bitter taste enhancing effect and/or pain reducing effect and volatility, and moisturizing properties are also taken into consideration. It can be seen that for 100 parts by weight of dinatonium benzoate, 500,000 to 800,000 parts by weight of sorbitol is more preferable, and 500,000 to 600,000 parts by weight is more preferable. In particular, it can be seen that at a content of 600,000 parts by weight of sorbitol relative to 100 parts by weight of denatonium benzoate, the bitter taste enhancing effect and/or pain reducing effect, volatility, moisturizing properties, etc. are excellent. Considering these results, the subsequent experiment was conducted based on the content of 600,000 parts by weight of sorbitol relative to 100 parts by weight of denatonium benzoate.

<Experimental Example 4> Viscosity increasing agent effect experiment

4-1. viscosity experiment

As shown in Table 4, samples with different viscosity enhancer contents were prepared, and the viscosity of each sample was measured using a viscometer (rotational viscometer, 25°C). Each sample was prepared by mixing the ingredients listed in Table 4 in purified water (remaining amount). The results are shown in Table 4.

sample	Dinatonium Benzoate (weight%)	Sorbitol (weight%)	xanthan gum (weight%)	viscosity (CPS)
10	0.005	30	0.03	10
11	0.005	30	0.05	20
12	0.005	30	0.1	50

As shown in the table, Sample 11 (a sample containing 1000 parts by weight of xanthan gum based on 100 parts by weight of dinatonium benzoate), Sample 12 (a sample containing 2000 parts by weight of xanthan gum based on 100 parts by weight of dinatonium benzoate) Viscosity was found to be more desirable. Sample 10 (a sample containing 600 parts by weight of xanthan gum relative to 100 parts by weight of dinatonium benzoate) appeared in a relatively diluted state.

4-2. volatility experiment

As shown in Table 5, samples with different viscosity enhancer contents were prepared, and the time required for each sample until the end of volatilization was measured. Each sample was prepared by adding the ingredients listed in Table 5 to purified water (remaining amount) and mixing them. The results are shown in Table 5.

sample	Dinatonium Benzoate (weight%)	Sorbitol (weight%)	xanthan gum (weight%)	volatility {time (seconds)}
10	0.005	30	0.03	25
11	0.005	30	0.05	28
12	0.005	30	0.1	35

As shown in the table, Sample 10 (a sample containing 600 parts by weight of xanthan gum based on 100 parts by weight of dinatonium benzoate) and Sample 11 (a sample containing 1000 parts by weight of xanthan gum based on 100 parts by weight of dinatonium benzoate) were It can be seen that the volatility is excellent and a film can be formed in a short time. Sample 12 (a sample containing 2000 parts by weight of xanthan gum relative to 100 parts by weight of dinatonium benzoate) was found to have relatively low volatility.

From the above experimental results, considering both volatility and viscosity, it can be seen that a content of 800 to 1,500 parts by weight of xanthan gum is preferable for 100 parts by weight of denatonium benzoate in the composition for preventing finger sucking. In other words, it can be seen that at this ratio, the viscosity and volatility are excellent, and the formation of the coating surface is smoother.

<Experimental Example 5> Preservative power experiment

As shown in Table 6, samples with different contents were prepared and a preservative power test was conducted (Korea Ministry of Food and Drug Safety Notice No. 2019-27 Regulations on Cosmetic Safety Standards, etc., Annex 4 Microbial Limit Items among Liquid Cosmetic Safety Management Test Methods reference). Each sample was prepared by adding the ingredients listed in Table 6 to purified water (remaining amount) and mixing them. The results are shown in Table 6.

sample	13	14	15
Dinatonium Benzoate (weight%)	0.005	0.005	0.005
Sorbitol (weight%)	30	30	30
xanthan gum (weight%)	0.03	0.05	0.05
Hydrolyzed Keratin (weight%)	One	One	One
Butylene glycol (weight%)	0.4	0.56	0.8
caprylyl glycol (weight%)	0.045	0.072	0.09
Pentylene glycol (weight%)	0.045	0.072	0.09
Hydroxyacetophenone (weight%)	0.01	0.016	0.02
preservative power	fitness	fitness	fitness

As shown in the table, Sample 13 (a sample containing 200 parts by weight of hydroxyacetophenone, based on 100 parts by weight of dinatonium benzoate), Sample 14 (320 parts by weight of hydroxyacetophenone, based on 100 parts by weight of dinatonium benzoate) The preservative power of both Sample 15 (corresponding to 100 parts by weight of dinatonium benzoate and 400 parts by weight of hydroxyacetophenone) was found to be adequate.

From the above results, it can be seen that in one embodiment of the present invention, by combining denatonium benzoate, which has a bitter taste, with sorbitol, which has a sweet taste, the bitter taste is strengthened, making it possible to prevent finger sucking more effectively. In addition, it can be seen that one embodiment of the present invention not only has an excellent bitter taste enhancing effect, but also has excellent properties such as volatility and moisturizing properties, so it is easy to apply to nails and also has a nail-protecting effect.

<Preparation Example 1> Preparation of composition for preventing finger sucking

A composition for preventing finger sucking was prepared using the ingredients and composition in Table 7. Specifically, the composition was prepared by mixing the ingredients in Table 7 with purified water (remaining amount), and the prepared composition was filled into a nail polish container (10 ml) or a pencil-type cosmetic container (3 ml).

Manufacturing example	One
Dinatonium Benzoate (% by weight)	0.005
Sorbitol (% by weight)	30
Xanthan gum (% by weight)	0.05
Hydrolyzed Keratin (% by weight)	One
Butylene glycol (% by weight)	0.56
Caprylyl Glycol (% by weight)	0.072
Pentylene glycol (% by weight)	0.072
Hydroxyacetophenone (% by weight)	0.016

According to the present invention, finger sucking can be prevented more effectively by enhancing the bitter taste of the composition for preventing finger sucking applicable to nails or reducing pain while maintaining the bitter taste to a certain degree. Therefore, the present invention has industrial applicability.

Claims (5)

1. A composition for preventing finger sucking applicable to nails containing denatonium benzoate and sorbitol.
2. The composition for preventing finger sucking according to claim 1, wherein the composition contains 400,000 to 800,000 parts by weight of sorbitol based on 100 parts by weight of denatonium benzoate.
3. The composition for preventing finger sucking applicable to nails according to claim 1, further comprising a viscosity enhancer.
4. The composition of claim 1, wherein the composition is a cosmetic composition for preventing finger sucking applicable to nails.
5. The composition for preventing finger sucking according to claim 1, wherein the composition is a pharmaceutical composition.